Medicine and Health Sciences Commons^™

Racial And Ethnic Disparities In The Co-Occurrence Of Intellectual Disability And Autism: Impact Of Incorporating Measures Of Adaptive Functioning., Sarah M. Furnier, Ronald Gangnon, Julie L. Daniels, Susan Ellis Weismer, Cy Nadler, Karen Pazol, Nuri M. Reyes, Steven Rosenberg, Eric Rubenstein, Lisa D. Wiggins, Marshalyn Yeargin-Allsopp, Maureen S. Durkin

Manuscripts, Articles, Book Chapters and Other Papers

Intellectual disability (ID) commonly co-occurs in children with autism. Although diagnostic criteria for ID require impairments in both cognitive and adaptive functioning, most population-based estimates of the frequency of co-occurring ID in children with autism-including studies of racial and ethnic disparities in co-occurring autism and ID-base the definition of ID solely on cognitive scores. The goal of this analysis was to examine the effect of including both cognitive and adaptive behavior criteria on estimates of co-occurring ID in a well-characterized sample of 2- to 5-year-old children with autism. Participants included 3264 children with research or community diagnoses of autism enrolled …

Occupational Therapy Feeding And Eating Interventions For Autism Spectrum Disorders And Pervasive Developmental Disorders: A Systematic Review, Jordan T. Adolf, Hana M. Mattern

Occupational Therapy Capstones

Due to the limited evidence and lack of methodological rigor regarding feeding and issues in children with Autism Spectrum Disorders (ASD) and Pervasive Developmental Disorders (PDD), clinicians who treat children with these diagnoses rely on the limited amount of information and many are not aware of evidence-based interventions (Ahearn, Castine, Nault, & Green, 2001; Marshall, Hill, & Dodrill, 2013). The purpose of this scholarly project is to gather, critique, and determine efficacy of occupational therapy feeding and eating interventions for children with ASD and PDD.

We systematically reviewed literature for higher-level evidence, as defined by Level III evidence or above, …

Addressing Vehicle Safety For Children With Additional Emotional And Behavioral Needs, Madeline Aandal, Bailey Stotts

Occupational Therapy Capstones

Purpose: More than 148,000 children were injured in motor vehicle crashes in 2011 (Center for Disease Control and Prevention, 2014). Currently, while it is understood that transporting children with special needs likely to affect behaviors (SNLAB) provide safety challenges (Yonkman, Lawler, Talty, O’Neil, & Bull, 2013), there is little information regarding how to evaluate and intervene for this significant aspect of daily life. The purpose of this project was to develop an occupational therapy protocol for evaluation and intervention for car safety to be used by occupational therapists working with children who have emotional and behavioral needs.

Methodology: An extensive …

Facilitating Play Amongst Siblings When One Is Diagnosed With Asd: Guide, Anne Lee, Kasie Parker

Occupational Therapy Capstones

No abstract provided.

Cc2d1a Regulates Human Intellectual And Social Function As Well As Nf-Κb Signaling Homeostasis., M. Chiara Manzini, Lan Xiong, Ranad Shaheen, Dimira E Tambunan, Stefania Di Costanzo, Vanessa Mitisalis, +15 Additional Authors

Pharmacology and Physiology Faculty Publications

Autism spectrum disorder (ASD) and intellectual disability (ID) are often comorbid, but the extent to which they share common genetic causes remains controversial. Here, we present two autosomal-recessive "founder" mutations in the CC2D1A gene causing fully penetrant cognitive phenotypes, including mild-to-severe ID, ASD, as well as seizures, suggesting shared developmental mechanisms. CC2D1A regulates multiple intracellular signaling pathways, and we found its strongest effect to be on the transcription factor nuclear factor κB (NF-κB). Cc2d1a gain and loss of function both increase activation of NF-κB, revealing a critical role of Cc2d1a in homeostatic control of intracellular signaling. Cc2d1a knockdown in neurons …

Self-Injurious Behaviours Are Associated With Alterations In The Somatosensory System In Children With Autism Spectrum Disorder., Emma G Duerden, Dallas Card, S Wendy Roberts, Kathleen M Mak-Fan, M Mallar Chakravarty, Jason P Lerch, Margot J Taylor

Brain and Mind Institute Researchers' Publications

Children with autism spectrum disorder (ASD) frequently engage in self-injurious behaviours, often in the absence of reporting pain. Previous research suggests that altered pain sensitivity and repeated exposure to noxious stimuli are associated with morphological changes in somatosensory and limbic cortices. Further evidence from postmortem studies with self-injurious adults has indicated alterations in the structure and organization of the temporal lobes; however, the effect of self-injurious behaviour on cortical development in children with ASD has not yet been determined. Thirty children and adolescents (mean age = 10.6 ± 2.5 years; range 7-15 years; 29 males) with a clinical diagnosis of …

Cross-Cultural Comparison Of Sensory Behaviors In Children With Autism., Kristina G Caron, Roseann C Schaaf, Teal W. Benevides, Eynat Gal

Department of Occupational Therapy Faculty Papers

Parents of children with autism frequently report that their children exhibit unusual responses to sensory experiences. Little research is available, however, describing how parents' and children's culture and environment might influence parents' reports of their children's behaviors. This study compared the frequency of parent-reported responses to sensory experiences in children from two countries-Israel and the United States. We administered the Short Sensory Profile to primary caregivers of children with autism spectrum disorders (ASD) and typically developing peers. Results indicate that Israeli parents reported unusual responses to sensory experiences less frequently than U.S. parents for both ASD and typically developing children. …

A Guide For Teachers And Paraprofessionals Working With Children With Autism Spectrum Disorder, Lesley Fettig

Occupational Therapy Capstones

The purpose of this scholarly project was to create a resource for occupational therapists in the public school system to provide a guide to educators and paraprofessionals working with children with autism spectrum disorder. The resulting guide for the occupational therapist provides the necessary materials to develop child specific guides for the educator and paraprofessional. The product provides education and guidance to optimize the educator and paraprofessional's ability to provide for the needs of a child with autism spectrum disorder in the school environment.

A comprehensive literature review was conducted to examine current best practice and treatment guidelines for autism …

An Occupational Therapy Based Education Course For Caregivers Of Children With Pervasive Developmental Disorders, Krystal Cook

Occupational Therapy Capstones

No abstract provided.