Medicine and Health Sciences Commons^™

Mapping The Arrangement Of Neural Ensembles Involved In Distinct Stages Of Spatial Memory Processing In Hippocampal Regions, Mikayla Hutchinson, Juan Marcos Alarcón, Phd, Adriana Melchiades, Phd

Journal of Health Disparities Research and Practice

Memory traces are believed to be supported by neural ensembles sculpted by learning activity. Reactivation of these ensembles would elicit memory recall. Although the recruitment of neural ensembles appears to be essential to memory formation and storage, not much is known of the exact arrangement of such ensembles during memory processes.

The goal of this project is to identify ensembles of neurons associated with distinct stages of the processing of a spatial memory in the hippocampus of mice. We hypothesize that as memory progresses, from early to late (more consolidated) stages, the majority of neurons constituting the ensemble will migrate …

Pathological Changes In Hippocampal Synaptic Transmission And Neuronal Function During Early Disease In The Novel Tgf344-Ad Rat Model, Lindsey Allyson Smith

All ETDs from UAB

Alzheimer’s disease (AD) is the leading cause of dementia in those 65 years and older and the 6th leading cause of death in the United Sates. Current treatments only target symptoms of the disease and cannot slow or halt disease progression. The novel and comprehensive TgF344-AD rodent model may bridge the translational gap previous animal models have failed to traverse by providing the platform to probe pre-lesion synapse dysfunction, which is thought to result primarily from increased levels of toxic soluble amyloid beta and hyperphosphorylated tau. The most recently developed model, the TgF344-AD rat was created in 2013 by insertion …

Estradiol-Mediated Spine Changes In The Dorsal Hippocampus And Medial Prefrontal Cortex Of Ovariectomized Female Mice Depend On Erk And Mtor Activation In The Dorsal Hippocampus, J. J. Tuscher, V. Luine, M. Frankfurt, K. M. Frick

Journal Articles

No abstract provided.

Distributed Encoding Of Spatial And Object Categories In Primate Hippocampal Microcircuits, Ioan Opris, Lucas M. Santos, Greg A. Gerhardt, Dong Song, Theodore W. Berger, Robert E. Hampson, Sam A. Deadwyler

Neuroscience Faculty Publications

The primate hippocampus plays critical roles in the encoding, representation, categorization and retrieval of cognitive information. Such cognitive abilities may use the transformational input-output properties of hippocampal laminar microcircuitry to generate spatial representations and to categorize features of objects, images, and their numeric characteristics. Four nonhuman primates were trained in a delayed-match-to-sample (DMS) task while multi-neuron activity was simultaneously recorded from the CA1 and CA3 hippocampal cell fields. The results show differential encoding of spatial location and categorization of images presented as relevant stimuli in the task. Individual hippocampal cells encoded visual stimuli only on specific types of trials in …

Acetylcholine Release In Mouse Hippocampal Ca1 Preferentially Activates Inhibitory-Selective Interneurons Via Α4Β2* Nicotinic Receptor Activation, L. Andrew Bell, Karen A. Bell, A. Rory Mcquiston

Anatomy and Neurobiology Publications

Acetylcholine (ACh) release onto nicotinic receptors directly activates subsets of inhibitory interneurons in hippocampal CA1. However, the specific interneurons activated and their effect on the hippocampal network is not completely understood. Therefore, we investigated subsets of hippocampal CA1 interneurons that respond to ACh release through the activation of nicotinic receptors and the potential downstream effects this may have on hippocampal CA1 network function. ACh was optogenetically released in mouse hippocampal slices by expressing the excitatory optogenetic protein oChIEF-tdTomato in medial septum/diagonal band of Broca cholinergic neurons using Cre recombinase-dependent adeno-associated viral mediated transfection. The actions of optogenetically released ACh were …

Acetylcholine Release In Mouse Hippocampal Ca1 Preferentially Activates Inhibitory-Selective Interneurons Via Α4Β2* Nicotinic Receptor Activation, L. Andrew Bell, Karen A. Bell, A. Rory Mcquiston

Anatomy and Neurobiology Publications

Acetylcholine (ACh) release onto nicotinic receptors directly activates subsets of inhibitory interneurons in hippocampal CA1. However, the specific interneurons activated and their effect on the hippocampal network is not completely understood. Therefore, we investigated subsets of hippocampal CA1 interneurons that respond to ACh release through the activation of nicotinic receptors and the potential downstream effects this may have on hippocampal CA1 network function. ACh was optogenetically released in mouse hippocampal slices by expressing the excitatory optogenetic protein oChIEF-tdTomato in medial septum/diagonal band of Broca cholinergic neurons using Cre recombinase-dependent adeno-associated viral mediated transfection. The actions of optogenetically released ACh were …

Global Ischemia And Turn Preference; Acomparative Study Of The Effects Of Globalischemic Insult In Rats, Akçahan Gepdi̇remen, Cemal Gündoğdu, Sinan Sönmez, Dilek Sadeler, Halis Süleyman, Mehmet Emin Büyükokuroğlu

Turkish Journal of Medical Sciences

We examined the effect of global cerebral ischemia (Two vessel occlusion plus systemic hypotension method) for 15 minutes on the hippocampal CA1 and CA3 neurones in rats, and compared with turn prefence scores. 14 of 27 animals were ambidexter while 9 had left and 4 had right turn preference. The left turns were significantly different from rights (t:2,26 df:26 p:0,032). Male rats prefered 62,73% and females 56,88% left turns. Forty-eight hours following the global cerebral ischemic insult, animals were sacrificed and brains were examined by using light microscope. Hippocampal neurones of the right hemisphere were survived more in males while …