Medicine and Health Sciences Commons^™

Effects Of Chronic And Acute Oestrogen Replacement Therapy In Aged Animals After Experimental Stroke, Louise D. Mccullough, Fudong Liu, S. E. Benashski, M. Siegel

UCHC Articles - Research

The effect of oestrogen replacement therapy (ERT) on stroke incidence and severity has been extensively debated. Clinical trials of ERT have demonstrated an increased risk of stroke in treated women, although the study participants were well past menopause when therapy was initiated. It has been suggested that detrimental effects of ERT may be unmasked after prolonged periods of hypoestrogenicity. To date, very few studies have examined the effect of ERT in aged animals, although the timing of replacement may be critical to the neuroprotective effects of ERT. We hypothesised that chronic ERT initiated in late middle age would decrease infarct …

Do Indigenous Australians Age Prematurely? The Implications Of Life Expectancy And Health Conditions Of Older Indigenous People For Health And Aged Care Policy, Philippa R. Cotter, John R. Condon, Tony Barnes, Ian P.S. Anderson, Leonard R. Smith, Teresa Cunningham

Aboriginal Policy Research Consortium International (APRCi)

Objective. To assess whether Indigenous Australians age prematurely compared with other Australians, as implied by Australian Government aged care policy, which uses age 50 years and over for population-based planning for Indigenous people compared with 70 years for non-indigenous people.

Methods. Cross-sectional analysis of aged care assessment, hospital and health survey data comparing Indigenous and non-indigenous age-specific prevalence of health conditions. Analysis of life tables for Indigenous and non-indigenous populations comparing life expectancy at different ages.

Results. At age 63 for women and age 65 for men, Indigenous people had the same life expectancy as non-indigenous people at age 70. …

Preparing For An Ageing Population: A Survey Of Older Patients' Attitudes To General Practice Registrars, Andrew D. Bonney, Sandra C. Jones, Lyn Phillipson, Donald C. Iverson

Sandra Jones

The ageing population makes it imperative to provide appropriate training for general practice registrars (GPRs) in the community-based care of older patients. However, data suggest that older patients may be less willing to consult GPRs for chronic/complex care; adversely affecting training opportunities and potentially the satisfaction of older patients in training practices. This cross-sectional study was undertaken to investigate this concern in the Australian context and develop models of older patient-GPR interaction that are acceptable to patients.

Information Placed In Trust: Older Gay Men And Social Workers On Talking About Sexual Identity In Aged Care, Mark Hughes

Professor Mark Hughes

As more men who openly identify as gay approach older age, it is important for health and aged care professionals to consider the appropriateness of talking with these men about their sexual identity. This paper reports findings from a pilot study that examined how sexual identity should be acknowledged in aged care practice. The paper draws on qualitative data from two focus groups; one with older gay men and one with social workers. An analysis of the themes that overlapped the two groups highlighted the extent to which participants thought sexual identity should be discussed openly, the value placed on …

Information Placed In Trust: Older Gay Men And Social Workers On Talking About Sexual Identity In Aged Care, Mark Hughes

Professor Mark Hughes

As more men who openly identify as gay approach older age, it is important for health and aged care professionals to consider the appropriateness of talking with these men about their sexual identity. This paper reports findings from a pilot study that examined how sexual identity should be acknowledged in aged care practice. The paper draws on qualitative data from two focus groups; one with older gay men and one with social workers. An analysis of the themes that overlapped the two groups highlighted the extent to which participants thought sexual identity should be discussed openly, the value placed on …

Ageing, Chronic Alcohol Consumption And Folate Are Determinants Of Genomic Dna Methylation, P16 Promoter Methylation And The Expression Of P16 In The Mouse Colon, Julia Sauer, Hyeran Jang, Ella M. Zimmerly, Kyong-Chol Kim, Zhenhua Liu, Aurelie Chanson, Donald E. Smith, Joel B. Mason, Simonetta Friso, Sang-Woon Choi

Zhenhua Liu

Older age, dietary folate and chronic alcohol consumption are important risk factors for the development of colon cancer. The present study examined the effects of ageing, folate and alcohol on genomic and p16-specific DNA methylation, and p16 expression in the murine colon. Old (aged 18 months; n 70) and young (aged 4 months; n 70) male C57BL/6 mice were pair-fed either a Lieber-DeCarli liquid diet with alcohol (18 % of energy), a Lieber-DeCarli diet with alcohol (18 %) and reduced folate (0·25 mg folate/l) or an isoenergetic control diet (0·5 mg folate/l) for 5 or 10 weeks. Genomic DNA methylation, …

Preparing For An Ageing Population: A Survey Of Older Patients' Attitudes To General Practice Registrars, Andrew D. Bonney, Sandra C. Jones, Lyn Phillipson, Donald C. Iverson

Faculty of Health and Behavioural Sciences - Papers (Archive)

The ageing population makes it imperative to provide appropriate training for general practice registrars (GPRs) in the community-based care of older patients. However, data suggest that older patients may be less willing to consult GPRs for chronic/complex care; adversely affecting training opportunities and potentially the satisfaction of older patients in training practices. This cross-sectional study was undertaken to investigate this concern in the Australian context and develop models of older patient-GPR interaction that are acceptable to patients.

The Buccal Cytome And Micronucleus Frequency Is Substantially Altered In Down’S Syndrome And Normal Ageing Compared To Young Healthy Controls, Philip Thomas, Sarah Harvey, Tini Gruner, Michael Fenech

Dr Tini M Gruner

The buccal micronucleus cytome assay was used to investigate biomarkers for DNA damage, cell death and basal cell frequency in buccal cells of healthy young, healthy old and young Down's syndrome cohorts. With normal ageing a significant increase in cells with micronuclei (P < 0.05, average increase +366%), karyorrhectic cells (P < 0.001, average increase +439%), condensed chromatin cells (P < 0.01, average increase +45.8%) and basal cells (P < 0.001, average increase +233%) is reported relative to young controls. In Down's syndrome we report a significant increase in cells with micronuclei (P < 0.001, average increase +733%) and binucleated cells (P < 0.001, average increase …

Long-Chain Omega-3 Pufas And Their Role In Healthy Ageing, Craig S. Patch, Ian L. Brown

Faculty of Health and Behavioural Sciences - Papers (Archive)

The effects of various fat subtypes can have a profound influence on our health and performance, not only in the early years of life but also as we age. The long-chain omega-3s docosahexaenoic and eicosapentaenoic acid appear to have a positive role in our mental and physical health.

Clinical Educators' Reactions To Ageing, Anne Mandy, Kevin Lucas, Lisa Hodgson

Internet Journal of Allied Health Sciences and Practice

Ageism and negative attitudes towards ageing have been identified within the literature as a cause for concern. Reactions to ageing are known to be strongly positively correlated with attitudes towards older people in general. Moreover, the link between ageist practice and quality of care is also established, but implications for education and training have not been explored. The aim of this study was to investigate the reactions to ageing of clinical and fieldwork educators of undergraduate students. Clinical and field work educators are largely responsible for all the clinical education received by these students and thus have the potential to …

Timed Stance Performances Reflect Differences In Age, Prevalence Of Co-Morbidities, Medication Use, Fall’S History And Activity Level: Early Screening For Balance Loss Is Indicated, Nancy Low Choy, Sandra Brauer, Jennifer Nitz

Nancy Low Choy

Objectives:
To determine if 10-second trials of bilateral and one-legged stance measures detected balance loss and influence of known risk factors for falls in women aged 20–80 years.

Methods:
456 healthy adult women attempted 10-second trials of bilateral stance (firm and foam surfaces) and one-legged stance, with eyes open (EO) and eyes closed (EC). Data for age, co-morbidities, medication use, fall history and activity level were compared for three categories of stability: (i) stable: all trials completed; (ii) unsteady: completed/failed one to two trials; and (iii) failed all trials.

Results:
Bilateral stance on foam (EC) and one-legged stance (EO) yielded …

Becoming A Carer For An Elderly Person After Discharge From An Acute Hospital Admission :, Karen Grimmer, John Moss, Julie Falco

Internet Journal of Allied Health Sciences and Practice

Objective: To describe the perceptions of people taking on a new or expanded caring role for an elderly patient recently hospitalised with a new or intensified health problem. Design: Observational study collecting qualitative data monthly for six months following patients’ discharge from hospital and attempted return to independent living in the community. Setting: Four South Australian acute hospitals (one metropolitan, three country). Subjects: 34 unpaid carers were nominated by 100 patients. 24 carers participated (17 elderly spouses, 3 younger family members, 4 neighbours and/ or friends). Results: The study highlighted carers’ perceptions of being unprepared for their new tasks, and …

Age And Gender Associated Changes In Cystatin C And \Beta 2 -Microglobulin, Zuhal Parildar, Ceyda Gülter, Sara Habi̇f, Işil Mutaf, Nevbahar Turgan, Di̇lek Özmen, Oya Bayindir

Turkish Journal of Medical Sciences

Assessment of renal function in clinical medicine is of great importance. Various studies report that cystatin C (cysC) and \beta 2 -microglobulin are valuable markers of renal function. In this study, serum cysC and \beta 2 -microglobulin were measured in parallel with serum creatinine in a healthy population, and the characteristics of the relationship of cysC and \beta 2 -microglobulin to age and gender were compared. Serum creatinine, cysC and b2-microglobulin were measured in 119 (86 female; 33 male, 6 to 69 years old) healthy subjects. They were divided into five different age groups: group 1 (6-15 years, n = …

The Effect Of Sulfur Dioxide On T-Butyl Hydroperoxide Induced Oxidative Stress In Lung Tissues Of Rats, Saadet Gümüşlü, Di̇jle Ki̇pmen Korgun, Süreyya Bi̇lmen, Gülteki̇n Yücel, Pi̇raye Yargiçoğlu, Aysel Ağar

Turkish Journal of Medical Sciences

In this study, the effects of sulfur dioxide (SO_2) ,a common pollutant in urban air, on t-butyl hydroperoxide-induced oxidative stress in rat lung tissues were examined. Ten young rats and 10 adult rats were exposed to SO_2 while another 10 young rats and 10 adult rats made up the control groups. Ten ppm SO_2 was administered to the animals of the SO_2 groups in an exposure chamber for one hour a day every day for 6 weeks. The control groups were exposed to filtered air in the same chamber for the same period. At the end of the experimental period, …

Nutrition And Ageing In Africa, Karen E. Charlton

Faculty of Science, Medicine and Health - Papers: part A

Although the proportion of elderly people in African populations is much smaller than that in developed countries, the absolute numbers of older Africans are rapidly increasing. The huge majority of Africans live in poor economic circumstances and few countries are able to offer social assistance programs. The health and wellbeing of older persons largely depend on the integral existence of informal services, social support networks and kin support. African gerontologists have urged social welfare policy makers to take cognizance of self-organized intergenerational help systems already present on the continent, and to make public-sector finance available to support these systems. Nutrition …

Uwomj Volume 35, Number 3, March 1965, Western University

University of Western Ontario Medical Journal

Schulich School of Medicine & Dentistry