Medicine and Health Sciences Commons^™

Weight Loss Patterns And Clinical Outcomes Of Glp1 Receptor Agonists In Breast Cancer Survivors, Jasmine S Sukumar, Akshara Singareeka Raghavendra, Sarah Pasyar, Roland L Bassett, Debu Tripathy, Carlos H Barcenas, Karen M Basen-Engquist, Banu K Arun

Faculty, Staff and Student Publications

Use of glucagon-like peptide-1 receptor agonists (GLP1-RA) for weight loss is increasing; implications in breast cancer (BC) survivors remain unclear.This retrospective cohort study evaluated treatment patterns, weight loss, and outcomes in BC survivors at an academic institution receiving GLP1-RA. We evaluated patients with non-metastatic (ductal carcinoma in situ (DCIS), stage 1-3) BC who received GLP1-RA (2005 - 2024). Linear regression models estimated associations between weight change and clinical factors. After excluding DCIS, propensity score matching (1:2) was used to match patients who received GLP1-RA with patients who did not, based on confounding covariates. Kaplan-Meier estimates and log-rank tests compared disease-free …

Mandibular Extension As A Trigger Of The Proprioceptive Trigeminocardiac Reflex, Massimo Conti, Giovanna Traina, Daniele Tonlorenzi

Turkish Journal of Medical Sciences

The trigeminocardiac reflex (TCR) is a physiological response characterized by a reduction in heart rate and arterial blood pressure following stimulation of any branch of the fifth cranial nerve. This review presents a novel mechanism of TCR induction through proprioceptive activation of the trigeminal nerve via mandibular extension (ME). Accordingly, it is referred to as the “proprioceptive trigeminocardiac reflex” (pTCR). An overview of the existing literature on ME-evoked TCR in humans and animals is presented, with particular emphasis on evidence of cerebral microcirculatory alterations. The magnitude of cardiovascular responses appears to depend on the duration of ME, with repeated applications …

Evaluation Of The Relationship Between Pan-Immune Inflammation Value And Prognostic Factors In Germ-Cell Testicular Cancer: Analysis Of Stage, Lymph Node Involvement, And Metastasis, Erdi̇nç Di̇nçer, Orkunt Özkaptan, Cengi̇z Çanakçi, Osman Murat İpek, Alper Coşkun, Ahmet Hali̇l Sevi̇nç

Turkish Journal of Medical Sciences

Background/aim: To evaluate the association between the preoperative pan-immune inflammation value (PIV) and prognostic factors, including stage, lymph node involvement, and metastasis, in patients who underwent radical orchiectomy for germ cell testicular tumors.

Materials and methods: Data from 178 patients who underwent radical orchiectomy for testicular tumors between January 2014 and January 2024 were retrospectively reviewed. Preoperative serum tumor markers, hematologic parameters, and histopathological findings were recorded. Tumor staging was determined based on radiological imaging and serum tumor markers. The PIV was calculated using the formula: (monocyte count × neutrophil count × platelet count) / lymphocyte count. Optimal cut-off values …

Validity Of The Turkish Version Of The Oral Frailty Index-8 And Its Relationship With Frailty, Malnutrition, And Sarcopenia In Older Adults, Süleyman Emre Koçyi̇ği̇t, Bi̇lal Kati̇poğlu, Yilmaz Önal, Kübra Bahar Baykan, İlknur Şeker Kaya, Fatma Sena Dost, Özge Dokuzlar, Esra Ateş Bulut, Ali̇ Ekrem Aydin, Derya Kaya, Ahmet Turan Işik

Turkish Journal of Medical Sciences

Background/aim: The Oral Frailty Index-8 (OFI-8) is a reliable screening for oral frailty. In our study, while presenting the Turkish reliability and validity study of the OFI-8, we also aimed to establish a cut-off value for oral frailty in Turkish population.

Materials and methods: Patients who presented to the outpatient clinic between January 2024 and January 2025 were evaluated. The test’s internal consistency and test–retest reliability were assessed. Divergent validity was evaluated using frailty scores, muscle strength, and nutritional status. A receiver operating characteristic (ROC) curve was generated to determine the optimal cut-off values for identifying frailty, malnutrition, and probable …

Canakinumab Treatment In Patients With Colchicine-Resistant Familial Mediterranean Fever: A Multicenter Observational Study, Emrah Koç, Mete Pekdi̇ker, Mete Kara

Turkish Journal of Medical Sciences

Background/aim: Anti-interleukin-1 agents have known beneficial effects in the treatment of colchicine-resistant familial Mediterranean fever (cr-FMF); however, studies to date have tended to have small sample sizes and to be based on pooled data. The present study investigates the efficacy of Canakinumab (CAN) in a homogeneous cohort of cr-FMF cases.

Materials and methods: The study included patients who underwent treatment in three tertiary rheumatology departments, whose electronic medical records were reviewed retrospectively. The inclusion criteria were presence of colchicine resistant disease activity or persistent proteinuria secondary to AA-amyloidosis, and treatment with CAN for at least 6 months. Clinical and laboratory …

Sarcopenia In Atrial Fibrillation: A Prospective Study, Mehmet Aki̇f Topçuoğlu, Ezgi̇ Yilmaz, Di̇nç Doğan Öge, Ali̇ Nai̇m Ceren, Ridvan Muhammed Adin, Ethem Murat Arsava

Turkish Journal of Medical Sciences

Background/aim: The link between atrial fibrillation (AF) and lean body mass is unclear. This study presents the effects of AF on sarcopenia indices, including ultrasonographic muscle architecture.

Materials and methods: In this study conducted in neurology units, 72 subjects with AF (mean age: 71 ± 11years, 49% female) were compared with 538 without AF (mean age:66±12years; 53% female) in terms of sarcopenia indices [anthropometry; Short Physical Performance Battery (SPPB); hand grip strength (HGS); bioimpedance analysis (BIA) indices; skeletal muscle mass index (SMMI) normalized to weight, height and body mass index (BMI); and phase angle (PhA)]; muscle ultrasonography [thickness, cross-section area …

Preoperative Inflammatory And Molecular Marker Changes In 125 Supratentorial Glioma Cases, Semi̇h Can Çeti̇ntaş, Burak Tahmazoğlu, Tufan Agah Kartum, Rahşan Kemerdere, Taner Tanriverdi̇

Turkish Journal of Medical Sciences

Background/aim: To determine whether there is a possible link between selected preoperative systemic inflammatory markers and molecular pathological indices.Material and methods: For this retrospective study, 125 patients served as subjects. Preoperative systemic inflammatory markers, namely neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and lymphocyte to monocyte ratio (LMR), and postoperative pathological indices, namely mitosis, Ki-67 labeling index (LI), isocitrate dehydrogenase-1 (IDH1) mutation, and 1p/19q codeletion, were obtained from the electronic database.

Results: Results showed that NLR positively correlated with PLR (p = 0.00001), mitotic activity (p = 0.001), and Ki-67 LI (p = 0.00001). On the other …

Ultrasound-Guided Microwave Ablation For The Treatment Of Abdominal Wall Scar Endometriosis, Saffet Öztürk, Umut Asfuroğlu, Esi̇n Kurtuluş Öztürk, Sadik Ahmet Uyanik, Gülcan Kocaoğlu, İsmai̇l Burak Gülteki̇n, Hüseyi̇n Levent Keski̇n

Turkish Journal of Medical Sciences

Background/aim: To evaluate the efficacy of ultrasound (US)-guided microwave ablation (MWA) in treating abdominal wall endometriosis (AWE) lesions located at the cesarean scar and to assess the early clinical outcomes of this minimally invasive procedure.

Materials and methods: A total of 18 patients diagnosed with AWE based on characteristic clinical and US findings were included in this retrospective study. Preprocedural visual analog scale (VAS) scores, ultrasonographic features, and lesion volumes were recorded. The procedure was performed under both general and local anesthesia to ensure patient comfort and procedural accuracy. Hydrodissection was performed before ablation to minimize the risk of thermal …

Preference Of Mechanical Ventilation Modes Among Intensivists In Türkiye: A National Wide, Point Prevalence Study, Süleyman Yildirim, Nurhayat Kilinç Özgün, Özcan Alpdoğan, Hüseyi̇n Uçar, İmren Taşkiran, Adnan Ata, Özhan Özcan, Kivanç Öncü, Saba Mukaddes Acarbay, Temel Güner, Pinar Özgün, Zerri̇n Özçeli̇k, Ayşegül Çinaroğlu, Gi̇zem Kurada, L. Serap Avlaği, Onur Gökçe, Özkul Yilmaz Çolak, Fatma Ülger, Melda İşevi̇, Özgür Kiliç, Rahi̇me Aydin Kayali, Meti̇n Yarici, Berkay Küçük, Fatma Yildirim, Kami̇l Gönderen, Bi̇şar Ergün, Kutlay Aydin, Kamuran Uluç, Sevda Onuk, Mi̇ne Altinkaya Çavuş, Yelda Balik, Ahmet Sari, Hayri̇ye Cankar Dal, Şeri̇fe Gökbulut Bektaş, Sema Turan, Ferhan Demi̇rer Aydemi̇r, Türkay Akbaş, Hamza Gülteki̇n, Kani̇ye Aydin, Seli̇n Eyüpoğlu, Havva Kocayi̇ği̇t, Gürhan Taşkin, Kazim Rollas, Mensure Çakirgöz, Cenk Kirakli

Turkish Journal of Medical Sciences

Background/aim: Invasive mechanical ventilation (IMV) is a fundamental intervention for patients with respiratory failure in intensive care units (ICUs). This nationwide, multicenter point-prevalence study aimed to describe current mechanical ventilation mode preferences (conventional, adaptive, and biphasic) in Turkish ICUs and to report associated clinical outcomes descriptively, without assessing causal relationships.

Materials and methods: A nationwide, multicenter point-prevalence study was conducted on 17 April 2024 and included adult patients (≥18 years) who had been receiving IMV for more than 24 h. Data on patient demographics, ventilation mode distribution, ventilatory parameters, and descriptive clinical outcomes on day 28 (weaning status, tracheostomy, and …

Retrospective Evaluation Of Treatment Outcomes Of Gasserian Ganglion Radiofrequency Thermocoagulation In Trigeminal Neuralgia Patients With Multiple Sclerosis, Emel Başar, Nevci̇han Şahutoğlu Bal, Erkan Yavuz Akçaboy

Turkish Journal of Medical Sciences

Background/aim: Trigeminal neuralgia (TN) secondary to multiple sclerosis (MS) is a rare but debilitating condition. Aside from two case reports, there are limited data on the use of Gasserian ganglion radiofrequency interventions in this patient population. This study aims to evaluate the outcomes of combined radiofrequency thermocoagulation (RFT) and pulsed radiofrequency (PRF) treatment targeting the Gasserian ganglion in patients with MS-related TN.

Materials and methods: We retrospectively analyzed 12 patients with MS-associated TN who underwent combined Gasserian ganglion RFT and PRF treatment between 1 January 2021 and 1 January 2025. Patients were followed for six months. Visual analog scale (VAS) …

Inflammation As A Harbinger Of Death: A Retrospective Cohort Study Of Preoperative Biomarker Risk Stratification In Orthopedic Trauma, Serkan Aydin, Burhan Kurtuluş

Turkish Journal of Medical Sciences

Background/aim: This study aimed to evaluate the prognostic significance of preoperative inflammatory markers including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), C-reactive protein (CRP), and procalcitonin in predicting 30-day and 1-year mortality in patients undergoing femur fracture surgery.

Materials and methods: This retrospective, multicenter cohort study included patients who underwent surgical treatment for femur fractures between January 2018 and December 2024. Patients were stratified into survivor and nonsurvivor groups based on 30-day and 1-year outcomes. Demographic characteristics, comorbidities, laboratory parameters, and inflammatory indices were recorded and analyzed. Linear and multivariate logistic regression analyses were performed to identify …

The Burden Of Knee Pain In The Operating Room: Are Surgical Personnel At Greater Risk?, Ömer Faruk Naldöven, Yavuz Karaman, Başak Si̇nem Sezgi̇n, Şahan Güven, Enejd Vei̇zi̇, İzzet Bi̇ngöl

Turkish Journal of Medical Sciences

Background/aim: This study aimed to determine the prevalence of knee pain among healthcare workers in surgical units and to explore whether the use of knee panels during surgical hand scrubbing is associated with persistent knee pain.

Materials and methods: This single-center cross-sectional study was conducted between October 2023 and March 2025. A total of 400 physicians and nurses working in surgical and nonsurgical departments were included. Participants completed a structured and modified Nordic Musculoskeletal Questionnaire, as well as knee pain assessment tools, including a visual analog scale (VAS) and the Kujala score for anterior knee pain-related symptoms. Occupational exposure among …

Etiologies Of Chronic Cough In Children: A Two-Year Experience From A Tertiary Pediatric Pulmonology Center, Yasi̇n Maruf Ergen, Nagehan Emi̇rali̇oğlu, Ebru Yalçin, Deni̇z Doğru, Uğur Özçeli̇k, Nural Ki̇per

Turkish Journal of Medical Sciences

Background/aim: Chronic cough is a common yet diagnostically challenging symptom in pediatric pulmonology. This study aimed to evaluate the etiologies of chronic cough in children referred to a tertiary center and to analyze the relationship between specific cough characteristics and final diagnoses.

Materials and methods: This retrospective study evaluated patients presenting with chronic cough (duration >4 weeks) at a tertiary pediatric pulmonology center. Demographic data, cough characteristics (wet vs. dry), and diagnostic findings were analyzed.

Results: A total of 62 patients were included. A specific etiology was identified in 95.1% of the patients. Asthma and reactive airway disease were the …

Clinical Features And Outcomes Of Childhood Interstitial Lung Disease: A Tertiary Center Experience, Ayyüce Ünlü, Şule Seli̇n Akyan Soydaş, Sati Özkan Tabakçi, Işil Bi̇lgi̇ç, Meltem Kürtül Çakar, Gamze Akca Di̇nç, Hande Yeti̇şgi̇n, Çelebi̇ Yildirim, Gökçen Di̇lşa Tuğcu, Di̇lber Ademhan Tural, Sanem Eryilmaz Polat, Güzi̇n Ci̇nel

Turkish Journal of Medical Sciences

Background/aim: Childhood interstitial lung diseases (chILD) constitute a rare and clinically complex group of disorders. This study aimed to characterize the clinical, radiological, and genetic features, as well as the outcomes, of chILD in a Turkish cohort classified according to the chILD-EU framework.

Materials and methods: We retrospectively reviewed the medical records of 84 pediatric patients diagnosed with chILD between 2017 and 2024 at a tertiary referral center in Türkiye. Patients were categorized according to the chILD-EU classification. Clinical variables, imaging findings, genetic analyses, pulmonary function test results, and Fan severity scores were systematically assessed. Logistic regression analysis was performed …

Proximal Fragment Perfusion Following Hip Arthroplasty With Subtrochanteric Shortening Osteotomy In Patients With Severe Developmental Dysplasia Of The Hip, Vedat Bi̇çi̇ci̇, Hi̇lmi̇ Alkan, Enejd Vei̇zi̇, Şahan Güven, Serkan Ünlü, Eli̇f Özdemi̇r, Tural Talibli, Ahmet Firat

Turkish Journal of Medical Sciences

Background/aim: The changes in proximal femoral blood flow occurring after reconstructive surgery for Crowe types III– IV developmental dysplasia of the hip (DDH) and their impact on healing remain unclear. In the present study, blood flow around the osteotomy site is evaluated with particular focus on the proximal segment in patients who underwent subtrochanteric shortening osteotomy and hip arthroplasty. To this end, single-photon emission computed tomography (SPECT/CT) scans were conducted to evaluate changes in proximal blood flow and to assess the impact on union rates and potential complications.

Materials and methods: A retrospective analysis was conducted of 26 hips from …

Feeding Time Index And Mortality In Intensive Care Stroke Patients: An Exploratory Cohort Study, Nevzat Mehmet Mutlu, Duygu Karaköse Çalişkan, Tülay Tunçer Peker, Özlem Balkiz Soyal, Ayşe Pinar Ti̇ti̇z, Behi̇ye Deni̇z Kosovali, Göksal Günerhan, Büşra Tezcan

Turkish Journal of Medical Sciences

Background/aim: Stroke is a major cause of morbidity and mortality worldwide, with especially high mortality in intensive care unit (ICU) patients, whose prognosis is worsened by dysphagia, malnutrition, and aspiration risk. The Feeding Time Index (FTI)—defined as the ratio of feeding days to total ICU length of stay—quantified nutritional exposure. This exploratory cohort study aimed to evaluate the association between FTI and mortality in ICU patients with acute ischemic stroke (IS) or hemorrhagic stroke (HS) and to examine the potential role of FTI, together with the Acute Physiology and Chronic Health Evaluation II (APACHE II) score and oral feeding status, …

Efficacy Of External Oblique Intercostal Plane Block In Postoperative Analgesia Following Laparoscopic Radical Nephrectomy, Gi̇zem Avci, Yusuf Özgüner, Damla Usalan, Cem Koray Çataroğlu, Habi̇p Yilmaz, Savaş Altinsoy, Jüli̇de Ergi̇l

Turkish Journal of Medical Sciences

Background/aim: The external oblique intercostal plane block (EOIB) is a regional anesthesia technique that may be utilized for the management of postoperative pain following laparoscopic radical nephrectomy. This study aims to evaluate the efficacy of EOIB after laparoscopic radical nephrectomy by comparing 24 h tramadol consumption between groups.

Materials and methods: Initially, 66 patients were enrolled in the study, and after exclusions, 60 were analyzed and divided into two groups: the EOIB group and the control group. Postoperative tramadol consumption, pain scores at rest and during movement, and dermatomal coverage of the block were recorded.

Results: The EOIB group (181.33 …

Association Of Mir-34a With Metastatic Progression Through The Foxo3a–Sirt1 Regulatory Axis In Breast Cancer, Banu Şahi̇n, İlker Batuhan Bural, Hüseyi̇n Özcan, Sendegül Yildirim, Gamze Tanriöver, Şükran Burçak Yoldaş

Turkish Journal of Medical Sciences

Background/aim: Breast cancer represents the foremost cause of cancer-related mortality among women worldwide and is characterized by a markedly high metastatic potential, contributing substantially to its clinical severity and poor prognosis. This study aimed to evaluate the interrelationship among silent information regulator (SIRT1), Forkhead box O3a (FoxO3a), and microRNA-34a (miR- 34a), the latter of which promotes apoptosis by suppressing the proliferation, migration, and invasion of breast cancer cells. Specifically, we investigated the tumor microenvironment associated with metastatic progression of malignant primary tumors, the influence of nonmetastatic (benign) tumors, and the potential roles of these proteins in both primary tumor development …

Assessing The Influence Of Third Molar Classification On The Risk Of Caries In Adjacent Teeth, Si̇nan Yasi̇n Ertem, Fati̇h Doğanoğlu, Fehi̇me Alkan Aygör

Turkish Journal of Medical Sciences

Background/aim: This study aimed to evaluate the relationship between the impaction level and angulation of third molars and the incidence of caries in the adjacent second molars.

Materials and methods: A total of 690 panoramic radiographs obtained from patients at Ankara Yıldırım Beyazıt University between May 2022 and January 2024 were retrospectively analyzed. Third molars were classified based on their eruption status using the Pell and Gregory classification (levels A, B, and C), and angulation (mesioangular, distoangular, vertical, horizontal, and inverted). The presence of caries in adjacent second molars was assessed using the international caries detection and assessment system/international caries …

The Enigmatic Role Of The C-Reactive Protein And Albumin In Behcet’S Disease, Zohreh Jadali

Turkish Journal of Medical Sciences

No abstract provided.

Neuroendocrine Effects Of Exogenous Adropin Administration On The Hypothalamic Pituitary Testicular Axis In Male Rats, Ersen Eraslan, Ayhan Tanyeli̇, Mustafa Can Güler, Asli Özbek Bi̇lgi̇n, Fazi̇le Nur Eki̇nci̇ Akdemi̇r, Eli̇f Polat, Seli̇m Çomakli, Nezahat Kurt, Tuğba Bal Taştan

Turkish Journal of Medical Sciences

Background/aim: Obesity impairs male fertility through metabolic dysfunction, oxidative stress, and disruption of the hypothalamic– pituitary–testicular (HPT) axis. Adropin (ADR), a peptide hormone whose circulating levels are reduced in obesity, plays emerging roles in metabolic homeostasis; however, its involvement in reproductive endocrine regulation remains unclear. The present study was conducted in healthy, nonobese male rats and aimed to investigate the neuroendocrine and testicular effects of exogenous ADR administration, focusing on circulating reproductive hormones, hypothalamic regulatory peptides, and testicular antioxidant pathways.

Materials and methods: Thirty-two male Wistar rats were randomized into control, sham, low-dose ADR (4 μg/kg/day), and high-dose ADR (40 …

Fitness Cost And Biofilm Formation In Fosfomycin-Resistant Clinical Escherichia Coli And Klebsiella Pneumoniae Isolates, Mustafa Ökeer, Sabi̇re Şöhret Aydemi̇r, Bayri Eraç

Turkish Journal of Medical Sciences

Background/aim: Fosfomycin has regained importance owing to its unique mechanism of action and effectiveness against extended-spectrum β-lactamase-producing Gram-negative bacteria. This study aimed to evaluate the biological fitness cost associated with fosfomycin resistance and its impact on biofilm formation in clinical Enterobacteriaceae isolates.

Materials and methods: A total of 78 Escherichia coli and 34 Klebsiella pneumoniae strains isolated from urine samples at Ege University Hospital were analyzed. Fosfomycin minimum inhibitory concentrations (MICs) were determined using the reference agar dilution method. Resistance was induced by exposing two K. pneumoniae strains with a fosfomycin MIC of 4 μg/mL and two E. coli strains …

Comment On “Survival Of Patients With 2014 Figo Stage Iiic High‑Grade Serous Ovarian Cancer Treated With Platinum‑Based Adjuvant Chemotherapy”, Abdullah Saad, Syeda Abeeha Hasan, Syeda Aki̇fa Sajid

Turkish Journal of Medical Sciences

No abstract provided.

Trends In The Psychedelic Renaissance: Applying Artificial Intelligence To Measure Media Portrayal Of Psychedelic Drugs In The 21st Century, David A. Bender, Harrison M. Dunn, Amanda Pekau, Arushi D. Mohite, Akila Anandarajah, Brendan D. Ross, Jacob Steinle, Suraj Shankar, Brandon Kiley, Umer Jalil

School of Medicine Publications

Background: The relationship between media portrayal of psychedelic drugs, scientific research and drug policy is an area of debate.

Aims: To apply artificial intelligence technology to measure trends in media sentiment towards the therapeutic potential of psychedelic drugs.

Method: Up to 300 of the most relevant articles from Google News searches for the term 'psychedelics' were sampled for each year from 2000 to 2025. A large language model, ChatGPT, evaluated subject matter and sentiment.

Results: In total, 88.3% of screened URLs (3308 of 3747) were included in the analysis. The proportion of articles focusing on the therapeutic potential of psychedelics …

Trends In The Psychedelic Renaissance: Applying Artificial Intelligence To Measure Media Portrayal Of Psychedelic Drugs In The 21st Century, David A Bender, Harrison M Dunn, Arushi D Mohite, Akila Anandarajah, Jacob Steinle, Suraj Shankar, Brandon Kiley, Sara Martin, Rishi Gonuguntla, Mia Stonov, Nithya Pippala, Rana Abdalla, Madison K Stille, Gibson Werner, Melinda Daniels-Tineo, Hannah Wang, Sonali Sharma, Jatin Sridhar, Adebusola Adeyemi, Kayla Smart, Baris C Ercal, Et Al.

2020-Current year OA Pubs

BACKGROUND: The relationship between media portrayal of psychedelic drugs, scientific research and drug policy is an area of debate.

AIMS: To apply artificial intelligence technology to measure trends in media sentiment towards the therapeutic potential of psychedelic drugs.

METHOD: Up to 300 of the most relevant articles from Google News searches for the term 'psychedelics' were sampled for each year from 2000 to 2025. A large language model, ChatGPT, evaluated subject matter and sentiment.

RESULTS: In total, 88.3% of screened URLs (3308 of 3747) were included in the analysis. The proportion of articles focusing on the therapeutic potential of psychedelics …

Menopause 101, Stephanie Carlson, Emma Parkhurst, Ashley Yaugher, Cris Meier

All Current Publications

This fact sheet provides women with basic information about perimenopause, menopause, and postmenopause, along with helpful tips and resources to better prepare for or manage these phases of life.

Small Patients, Big Gaps: Why Adult Crrt Timing Evidence Does Not Translate To Children, Katja M Gist, Dana Y Fuhrman, Ayse Akcan-Arikan

Faculty, Staff and Students Publications

No abstract provided.

Albumin-Binding Domains In Therapeutic Protein Engineering: A Structural And Computational Perspective On Rational Design, Matthew Argyle, Dallin M. Chipman, Anna Claire Woolley, Bradley C. Bundy, Dennis Della Corte

Faculty Publications

Therapeutic proteins face a critical pharmacokinetic challenge: rapid clearance from circulation limits their clinical efficacy. Albumin-binding domains (ABDs) offer an elegant solution by enabling therapeutic proteins to “hitchhike” on serum albumin’s favorable 19-day half-life through FcRn-mediated recycling. Clinical validation through approved therapeutics like ozoralizumab demonstrates the success of this approach, with preclinical studies showing fusion to an ABD extended half-life to 18 days. This review provides an analysis of ABD-fusion protein design, integrating structural biology, computational prediction, and rational engineering principles. We catalog the major classes of albumin-binding modalities, including bacterial three-helix bundle domains, engineered peptides, antibody-derived binders, and alternative …

What Did We Learn About Vads In 2024-2025?, Maya Guglin

The VAD Journal

This is our 11th annual literature review on left ventricular assist devices (LVADs). Our previous reports were well received by readers.^1-10 In prior years, we also included other forms of mechanical circulatory support (MCS); however, this year, we present a separate review focused exclusively on temporary MCS.

In this article, we summarize the most interesting, from our standpoint, publications from 2024 and 2025, with some inclusion of late 2023 studies that were initially released online before print. For the first time, we provide an independent review on short-term MSC devices, including the intra-aortic balloon pump, Impella (Abiomed), and extracorporeal …

Cytotoxic And Antimicrobial Effects Of Plant-Derived Compounds Used In Traditional Chinese Medicine, Amanda Ly, Diane Sun, Shelbi Salinas, Victor M. Jimenez

Annual Research Symposium

No abstract provided.