Medicine and Health Sciences Commons^™

Evidence-Based Practice Medication Reconciliation Protocol: Process To Increase Adherence To Medication Reconciliation Process, Oksana Bregman

Student Scholarly Projects

Practice Problem: The practice problem for the primary care facility is the inconsistent completion of medication reconciliation (MR) by primary care providers (PCPs), despite attempts by some providers to compare the clinic medication list with the external records and update the electronic health records (EHR). The absence of a standardized evidence-based practice (EBP) MR protocol has resulted in variable practices and increased risk for medication discrepancies during patient encounters.

PICOT: The PICOT question that guided this project was: In primary care providers (P), how does the Evidence-based practice process redesign and workflow optimization protocol (I) compared to current practice (C) …

Parents Engaging In Early Literacy (Peel): Outcomes From A Shared Reading Program Implemented Via Text Messaging, Victoria Henbest, Brenda L. Beverly, Gina M. Mejia

Victoria S. Henbest Publications

Purpose: Investigators delivered an asynchronous parent education for improving early literacy skills of typically developing preschoolers. The home-based shared-book reading program, PEEL, consisted of strategies modeled via videos and sent as text messages.

Method: Twenty parent-child dyads were randomly assigned to one of two 8-week programs targeting evidence-based early literacy strategies. One parent group was taught strategies to support print-related knowledge for learning to read, and the other learned skills to promote vocabulary and story knowledge underlying comprehension.

Results: The asynchronous parent education resulted in more frequent parental use of taught strategies compared to non-taught strategies during …

Randomized Controlled Trial Outcomes For Homestyles-2, An Online Obesity Prevention Program For Families With Children In Middle Childhood, Carol Byrd-Bredbenner, Angelica A. Pozzoli, Kaitlyn M. Eck, John Worobey, Karla Pagan Shelnutt, Melissa D. Olfert, Virginia Quick

College of Health Professions Faculty Papers

Background: Parents are children’s primary role models, are food and physical activity gatekeepers, and create the home structure/lifestyle environment. Thus, parents strongly influence children’s weight-related behaviors and have the opportunity to cultivate a “culture of health” within the home. Methods: The aim of the HomeStyles-2 (also called HomeStyles-Child) RCT was to determine whether this online, novel, age-appropriate, family intervention enabled and motivated the 131 systematically randomly assigned by computer parents of children in middle childhood (ages 6 to 11) in the experimental condition to shape home environments and healthy weight-related lifestyle practices to be more supportive of optimal health and …

The Psychology Of Offensive And Defensive Intergroup Violence: Preregistered Insights From 58 Countries, Jonas R. Kunst, Tomasz Besta, Michał Jaśkiewicz, Et Al, Lauren E. Duncan

Psychology: Faculty Publications

Historically, intergroup violence has been motivated by both offensive and defensive goals, often blending narratives of protection with ambitions of domination. In a preregistered study spanning 58 countries, we show that defensive and offensive extremist intentions are positively correlated yet psychologically distinct, relating differently to individual and societal factors. Defensive extremist intentions were far more common and primarily linked to narcissism and Machiavellianism, whereas offensive extremist intentions were primarily associated with social dominance orientation and religious fundamentalism, were lower in more democratic and developed societies, and higher in those experiencing violence and conflict. This global evidence suggests that violent extremist …

How Does Striving Against Adversity Impact Emotional Well-Being And Cardiovascular Risk In Children?, Brooks B. Gump, Stefanie Pilkay, Xiafei Wang, Sara Vasilenko, Nader H. Attallah-Yunes, Sarah Woolf-King, Stephen Maisto, Edith Chen, Craig K. Ewart

Population Health Research Brief Series

Working hard and persisting through challenges (i.e., striving) are often encouraged for children who face adversity.  But for children facing severe adversity, striving can come with hidden costs. This brief summarizes findings from a study using data from the Environmental Exposures and Child Health Outcomes (EECHO) cohort (N=283, 2013-2017) of children ages 9-11 in Syracuse, NY. The authors find that children facing adversity who strived harder reported lower depression and hostility. However, high-striving high-adversity children also experienced significantly higher blood pressure and enlarged heart chambers than their lower striving peers, both risk factors for future heart disease.

Molecular Characterization Of Humanized Apoe Mouse Models Reveals Source And Genotype Dependent Differences, Na Wang, Gefei Yu, Zhen Wang, Alla Alnobani, Suren Jeevaratnam, Xue Zhang, Meghan Mcreynolds, Yuzhou Chang, Fangfang Qi, William Tauer, Cassandra Rosenberg, Melissa Wren, Tadafumi C Ikezu, Yuka A Martens, Minghui Wang, Bin Zhang, Gregory W Carter, Michael Sasner, David M Holtzman, Junmin Peng, Long-Jun Wu, Takahisa Kanekiyo, Chia-Chen Liu, Guojun Bu

The Brown Foundation: Institute of Molecular Medicine

Background

Humanized APOE targeted-replacement (TR) mice are essential tools for studying apoE isoform effects in Alzheimer’s disease (AD) and other apoE-related disorders. Despite their widespread use, existing APOE mouse models, generated with different gene targeting strategies, have not been directly compared in terms of apoE isoform expression, lipid profiles, and transcriptomic signatures. Such differences could impact how we interpret APOE genotype-related outcomes, as well as related underlying molecular mechanisms.

Methods

We conducted a comprehensive molecular comparison of humanized APOE mouse models from three sources: Taconic Biosciences (TAC), the Cure Alzheimer’s Fund (CAF), and The Jackson Laboratory (JAX). We assessed apoE …

Racial And Ethnic Differences In The Clinical Presentation Of Celiac Disease In The United States: A Multi-Institutional Retrospective Analysis, Joy Zhao, John C. Lin, Jason C. Lin, Stephanie M. Moleski

Division of Gastroenterology and Hepatology Faculty Papers

No abstract provided.

Thalamic Organization Differentially Contributes To Clinical Conditions In Epilepsy, Qirui Zhang, Sam S. Javidi, Ankeeta Ankeeta, Michael R. Sperling, Zhiqiang Zhang, Joseph I. Tracy

Farber Institute for Neuroscience Faculty Papers

BACKGROUND: The thalamus plays an important role in key clinical conditions of focal temporal lobe epilepsy (TLE), but no investigation has examined whether the same thalamic local and connectome properties shape a patient's status across these different conditions.

METHODS: This retrospective longitudinal MRI study used resting-state fMRI and structural imaging to identify whole-brain focal/regional and connectome-level features associated with six binary clinical conditions of TLE (pre/post-surgery, seizure and neurocognitive outcomes, pathology, seizure subtype, and SOZ lateralization) in 91 patients across two centers (age range: 15-65 years) and 85 matched healthy participants (age range: 18-60 years).

RESULTS: Across conditions, relative to …

Impact Of Prior Bendamustine Exposure On Bispecific Antibody Outcomes In Relapsed/Refractory Follicular Lymphoma, Gloria Iacoboni, David A Russler-Germain, Jing Luan, Et Al.

2020-Current year OA Pubs

No abstract provided.

Perceived Partner Substance Use, Genetic Predispositions, And Their Associations With Problematic Alcohol Use, Emotional Well-Being, And Relationship Quality, Megan E Cooke, Kathleen K Bucholz, Vivia V. Mccutcheon, Et Al.

2020-Current year OA Pubs

BACKGROUND: Romantic relationships are important contexts for substance use and emotional well-being. We tested the hypotheses that (i) genetic predispositions for alcohol consumption would be positively associated with partner substance use, (ii) partner substance use would moderate genetic influences on one's own alcohol outcomes, and (iii) partner discordance in substance use would be associated with lower emotional well-being and relationship quality.

METHODS: Analyses included 2,357 participants (M

RESULTS: Participant PGS

CONCLUSIONS: The results highlight the importance of partner substance use in etiological models of alcohol use, emotional health outcomes, and relationship quality.

Complications And Outcomes Of Orbital Fracture Repair In Oman, Saleh Al Ghailani, Abdulaziz Bakathir, Ahmed Al Ajmi, Shuhra Al Washahi, Tiamour Al Baloshi, Ahmed Al Hashmi

Sultan Qaboos University Medical Journal

Objective: This study aimed to investigate and analyse the complications and outcomes of orbital fracture repair in Oman. Methods: This multicentre retrospective study included all patients with orbital floor and/or medial wall fractures who underwent orbital reconstruction at four tertiary hospitals in Oman between January 2014 and December 2021. The data collected included demographics, fracture aetiology, surgical approach, reconstruction material, complications and repair outcomes. Results: A total of 41 patients were included in this study. Motor vehicle collisions (MVCs) were the most common cause of orbital fractures, accounting for (53.7%) of the patients. Isolated orbital fractures were encountered in …

Tulane Virus Protease As A Structural Surrogate For Inhibitor Screening Of Human Norovirus Proteases, Son Pham, Nikhil Sharma, Banumathi Sankaran, Jalen Nguyen, Mary K Estes, Joseph M Hyser, B V Venkataram Prasad

Faculty, Staff and Students Publications

Human norovirus (HuNoV) is a significant cause of gastroenteritis worldwide, affecting people of all age groups. There are currently no vaccines or drugs available, leaving susceptible populations vulnerable to severe or protracted illness. A HuNoV cultivation system is pivotal for screening norovirus antivirals. While the human intestinal enteroid cultivation system allows robust replication of multiple HuNoV strains, it presents technical and cost barriers. Tulane virus (TV), a surrogate for HuNoV, replicates well in monkey kidney cell lines and is closely related to norovirus in cellular biology. Here, we determined the structures of TV protease (TV-Pro) alone and in complex with …

Clinical Characteristics, Management, And Hematopoietic Cell Transplantation Of Patients With Tlr8 Gain-Of-Function, Danielle E Arnold, Jahnavi Aluri, Sarah S Mehta, Joshua M Tobin, Laura G Schuettpelz, Nermina Saucier, Elizabeth G Schmitz, Jeffrey J Bednarski, Megan A Cooper, Et Al.

2020-Current year OA Pubs

Toll-like receptor 8 (TLR8) gain-of-function (GOF) somatic variants were recently identified as causing severe neutropenia, lymphoproliferation, and immune dysregulation. We report the expanded clinical and laboratory phenotype and management of 10 patients, including the original cohort of 6 male patients. We identify the first female patient with TLR8 GOF who presented during infancy with pure red cell aplasia due to a germ line TLR8 variant, and 2 new disease-causing somatic variants in male patients. Eight patients had somatic mosaicism with peripheral blood variant allele fractions of 7% to 26%, and age of disease onset of 9 months to 28 years. …

Lipocalin 2 Orchestrates Resistance To Ferroptosis Via Axl, Sabrina Z Wang, J Payton Timken, Ellen S Hong, Sehaj Kaur, Eli Newby, Kristen E Kay, Erin E Mulkearns-Hubert, Daniel J Silver, Juyeun Lee, Joshua B Rubin, James R Connor, Loic P Deleyrolle, Deanna Tiek, Andrew Dhawan, Justin D Lathia

2020-Current year OA Pubs

Glioblastoma (GBM) remains a lethal tumor, largely due to robust mechanisms that prevent effective induction of cell death. Ferroptosis, a form of iron-dependent cell death, is a promising vulnerability in GBM. Here, we demonstrate that lipocalin-2 (LCN2) suppresses ferroptosis in GBM cells via the receptor tyrosine kinase AXL. LCN2 was elevated in GBM cells compared to lower-grade tumor and non-transformed cells, and Lcn2 knockdown impaired GBM cell fitness and growth in vitro and in vivo. Mechanistically, Lcn2 knockdown triggered ferroptosis, which was specifically rescued with ferroptosis inhibitors but not apoptosis or necroptosis inhibitors. Lcn2 knockdown reduced AXL phosphorylation, which was …

Glomerular Basement Membrane Structural Integrity Dictates Trans-Tissue Deposition Of Laminin In The Kidney, Kohei Omachi, Meei-Hua Lin, Pongpratch Puapatanakul, Joshua F Begin, Karen K Mckee, Hironobu Fujiwara, Peter D Yurchenco, Jeffrey H Miner

2020-Current year OA Pubs

Basement membranes (BMs) are specialized extracellular matrices (ECMs) essential for tissue structure and function. In non-vertebrates, ECM components can be produced both locally and by distant tissues. In contrast, mammalian ECM has traditionally been considered to originate predominantly from adjacent or tissue-resident cells. The kidney glomerular basement membrane (GBM), composed of laminin-α5β2γ1 and collagen-α3α4α5(IV), is produced by neighboring cells and functions as a filtration barrier. Alport syndrome, a genetic kidney disease, is characterized by GBM structural defects and ectopic laminin-α2 deposition, but the source of this laminin remains unknown. Here, using CRISPR-Cas9 transgenic models, we demonstrated that ectopic laminin-α2 in …

Molecular Characterization Of Humanized Apoe Mouse Models Reveals Source And Genotype Dependent Differences, Na Wang, David M Holtzman, Et Al.

2020-Current year OA Pubs

BACKGROUND: Humanized APOE targeted-replacement (TR) mice are essential tools for studying apoE isoform effects in Alzheimer’s disease (AD) and other apoE-related disorders. Despite their widespread use, existing APOE mouse models, generated with different gene targeting strategies, have not been directly compared in terms of apoE isoform expression, lipid profiles, and transcriptomic signatures. Such differences could impact how we interpret APOE genotype-related outcomes, as well as related underlying molecular mechanisms. METHODS: We conducted a comprehensive molecular comparison of humanized APOE mouse models from three sources: Taconic Biosciences (TAC), the Cure Alzheimer’s Fund (CAF), and The Jackson Laboratory (JAX). We assessed apoE …

Contrast-Associated Acute Kidney Injury After Thrombectomy For Ischemic Stroke: Prognostic Impact And Can-Rest Predictive Score, Ghil Schwarz, Angelo Cascio Rizzo, Gareth Ambler, Pawel Wrona, Agnieszka Slowik, Szymonn Kotas, Mohamed F. Doheim, Alhamza R. Al-Bayati, Raul G. Nogueira, Ameer E. Hassan, Samantha Miller

School of Medicine Publications

Background and objectives: Contrast-associated acute kidney injury (CA-AKI) is a potentially preventable complication after exposure to iodinated contrast media. In patients undergoing endovascular thrombectomy (EVT) for acute ischemic stroke (AIS), the incidence and clinical impact are poorly characterized, and no validated prediction tool is currently available. The aim of this study was to assess the incidence and prognostic significance of CA-AKI in EVT-treated patients with AIS and to develop and validate a predictive score.

Methods: A retrospective, multicenter cohort study was conducted involving EVT-treated patients across 73 centers in 16 countries (January-December 2023). Inclusion criteria were age ≥18 years, absence …

“For Us, Drones Mean Health”: How Medical Drone Delivery Affects Healthcare Outcomes, Accessibility, And Trust In Remote Regions Of Madagascar, Brianne O'Sullivan, Christallin Lydovick Rakotoasy, Lorie Donelle Phd, Rn, Fcan, Nicole Haggerty, Elysée Nouvet

Faculty Publications

Medical drone delivery (MDD), defined as the use of uncrewed aerial vehicles to transport medical products, is an emerging technological innovation responding to persistent health supply chain challenges in rural and low-resource settings. Within sub-Saharan Africa, MDD systems have demonstrated large-scale success in improving key health outcomes, health supply chain efficiency, and reductions in medical product stockouts and wastage. However, the existing evidence base on the effectiveness of this technology is dominated by quantitative, performance-based evaluations, with limited emphasis on the community-driven mechanisms that shape such outcomes. Drawing on original qualitative research, this article presents a qualitative secondary analysis (QSA) …

Cystic Fibrosis And Sickle Cell Disease Associated With Nonadministration Of Vte Prophylaxis In Hospitalized Adults, Kiera Caparon, Matthew J. Lankiewicz, Jessica Crow, Jennifer C. Yui, John Lindsley, Brandyn D. Lau, Michael B. Streiff, Rakhi P. Naik, Sophie Lanzkron, Lydia H. Pecker, Peggy Kraus, Elliott R. Haut, Jiangxia Wang, Kathryn E. Dane

Cardeza Foundation for Hematologic Research

Cystic fibrosis (CF) and sickle cell disease (SCD) are associated with an increased risk of venous thromboembolism (VTE), and this risk is exacerbated by hospitalization. VTE prophylaxis nonadministration is a VTE risk factor. The objective of this study was to characterize VTE prophylaxis nonadministration among patients with either CF or SCD compared with medically ill patients without CF or SCD. We conducted a single-center retrospective cohort study of hospitalized patients who were prescribed at least 2 doses of pharmacologic VTE prophylaxis. The primary outcome was the proportion of nonadministered VTE prophylaxis doses by cohort. Multivariable logistic regression was used to …

A Cross-Sectional Survey On Hpv Vaccination In A Houston Hiv Clinic, Shailee R Modi, Erika S Fanous, Avery N Sinnathamby, Laura O Van Buskirk, Jason L Holliday, J Brooks Jackson, Mary B Rysavy

Faculty, Staff and Student Publications

Background/Objectives: Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide and causes cervical cancer in women. Patients with human immunodeficiency virus (HIV) are particularly susceptible to this virus. An effective vaccine against high-risk HPV genotypes is available. This study sought to evaluate barriers to HPV vaccination in HIV-positive female patients between the ages of 18 and 65 in a county clinic in Houston.

Methods: A cross-sectional survey was conducted in May-June 2025 with 131 patients at Thomas Street Health Center in Houston. The survey assessed patient demographics, attitudes toward and knowledge of HPV vaccination (at least one dose), …

Fecal Carbohydrate-Degrading Bacteria Are Associated With Reduced Incidence Of Lower Gastrointestinal Gvhd, Christopher Fan, Tomo Hayase, Chia-Chi Chang, Israel K Glover, Ivonne I Flores, Lauren K Mcdaniel, Miriam R Ortega, Christopher A Sanchez, Rawan K El-Himri, Alexandria N Brown, Jennifer L Karmouch, Mohamed A Jamal, Saira S Ahmed, Taylor M Halsey, Yimei Jin, Wen-Bin Tsai, Rishika Prasad, Altai Enkhbayar, Aqsa Mohammed, Maren Schmiester, Ashish Damania, Nadim J Ajami, Jennifer A Wargo, Christine B Peterson, Gabriela Rondon, Taha Al-Juhaishi, Amin M Alousi, Jeffrey J Molldrem, Richard E Champlin, Elizabeth J Shpall, Eric Martens, Cesar A Arias, Robert R Jenq, Eiko Hayase

Faculty, Staff and Student Publications

Lower gastrointestinal graft-versus-host disease (LGI-GVHD) carries morbidity and mortality for patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT), with critical contributions from the intestinal microbiome. In a retrospective cohort of metagenomic sequencing of stool from patients with allo-HSCT (N = 90), we found that a reduction in specific Parabacteroides and Bacteroides species around the time of engraftment contributes to LGI-GVHD risk. Given the known diverse carbohydrate-degrading functionality of these bacteria, we investigated gene abundances for carbohydrate-active enzymes (CAZymes) and found that Parabacteroides merdae, P distasonis, and Bacteroides ovatus abundances were significantly correlated with CAZymes in patients who did not develop …

Genome-Wide Crispr Screen Identifies A Cytokine-Enhancer Circuit Driving Hif-2Α Activation In Renal Cancer, Jun Fang, Jeremy M Simon, Tao Wang, Yunpeng Gao, Xianju Bi, Lianxin Hu, Chengheng Liao, Cheng Zhang, Yayoi Adachi, Jin Zhou, Hongyi Liu, Qian Liang, James A Nathan, Ram Mani, James Brugarolas, Qing Zhang

Faculty, Staff and Student Publications

Resistance to HIF-2α inhibitors such as Belzutifan underscores the need to better understand how HIF-2α is transcriptionally regulated in clear cell renal cell carcinoma (ccRCC). Here, we uncover a cytokine-driven enhancer mechanism that sustains HIF-2α expression through the JAK1-STAT3 signaling pathway. Using a genome-wide CRISPR screen in VHL-deficient ccRCC cells, we identified SOCS3 as a key negative regulator of HIF-2α. Mechanistically, loss of SOCS3 activates JAK1-STAT3 signaling, leading to the recruitment of STAT3 to distal enhancers upstream of EPAS1 that physically loop to its promoter to drive HIF-2α transcription. This cytokine-enhancer circuit was recapitulated in ccRCC patient samples and functionally …

Heterogeneity And Plasticity Of The Naive Cd4+ T Cell Compartment, Alia Sajani, Evelien Schaafsma, Walburga Croteau, Mohamed Eltanbouly, Elizabeth C Nowak, Chao Cheng, Christopher M Burns, Mary Jo Turk, Randolph J Noelle, J Louise Lines

Faculty, Staff and Students Publications

This study describes the transcriptional heterogeneity of murine and human naive CD4+ T cells as comprising multiple discrete clusters that impact CD4+ T cell fate and trajectories. Naive CD4+ T cells experiencing inflammatory environments exhibit an altered transcriptional state that biases their differentiation trajectories.

Conserved Neutrophil Degranulation Transcripts In Hiv-Tb Coinfected Children Across East And Southern Africa, Eric Katagirya, Busisiwe Mlotshwa, Samuel Kyobe, Savannah Mwesigwa, Gaone Retshabile, Lesedi Williams, Marion Amujal, John Mukisa, Gerald Mboowa, David P Kateete, Misaki Wayengera, Sununguko Wata Mpoloka, Angella N Mirembe, Ishmael Kasvosve, Koketso Morapedi, Makhosazana Dlamini, Betty Nsangi, Grace P Kisitu, Adeodata R Kekitiinwa, Gabriel Anabwani, Moses L Joloba, Eddie Mujjwiga Wampande, Dithan Kiragga, Florence Anabwani-Richter, Chester W Brown, Graeme Mardon, Neil A Hanchard, Mogomotsi Matshaba, And For The Collaborative African Genomics Network (Cafgen)

Faculty, Staff and Students Publications

Background: HIV-tuberculosis (HIV-TB) coinfection poses a significant public health challenge among children in high-burden African regions. Most previous transcriptomic studies have concentrated on adults and non-African populations, primarily analyzing gene-level differential expression. This approach overlooks multi-isoform complexity and may obscure both inherent and pathogen-induced intragenic heterogeneity. This multi-center case-control study aimed to identify and characterize the transcript-level landscape of HIV-TB coinfection in children from different African regions.

Methods: We analyzed whole-blood RNA sequencing data from 97 children with and without tuberculosis from Uganda (East Africa) and from Botswana and Eswatini (Southern Africa). Reads were quality-controlled, and low-abundance transcripts filtered out. …

Association Between Charcoal Cooking Fuel And Cardiovascular Disease Prevalence In Haiti: A Cross-Sectional Analysis, Lily D Yan, Mark D Huffman, Et Al.

2020-Current year OA Pubs

BACKGROUND: There is little evidence on the association between cooking with polluting fuels, particularly charcoal, and heart disease from low- and middle-income countries, which have the highest burdens of polluting fuels and cardiovascular disease (CVD). We sought to assess the relationship between self-reported primary home cooking with charcoal and prevalent cardiovascular disease in the low-income country Haiti. METHODS: Demographic and clinical data were collected from 3,005 adults in the Haiti Cardiovascular Disease Cohort, recruited from Port-au-Prince using multistage random sampling from 2019 to 2021. Primary cooking fuel was self-reported in the household: charcoal orliquified petroleum gas (LPG). Prevalent CVD (heart …

Drug Procurement Methods And Challenges In Asian Low And Lower-Middle-Income Countries: A Systematic Review, Ferina Septiani Damanik, Anna Wahyuni Widayanti, Muhammad Qowiyul Amin

The Thai Journal of Pharmaceutical Sciences

Background: Pharmaceutical procurement plays a pivotal role in healthcare within Asian low and lower-middle-income countries (LLMICs), ensuring accessibility to essential, cost-effective, and high-quality medicines. Tailored approaches are imperative due to specific challenges inherent in these countries.
Objectives: This review examines several drug procurement systems in Asian countries with LLMICs while identifying and evaluating any potential challenges that might arise within the systems.
Materials and Methods: This review using the preferred reporting items for systematic reviews and meta-analyses guidelines and three search engines (PubMed, Science Direct, and Research Gate) employing Boolean search terms. The search focuses on drug procurement, medicine procurement, …

Efficacy And Safety Of Stem Cell-Based Interventions For Burn Wound Healing: A Systematic Review And Meta-Analysis Of Pre-Clinical And Early Clinical Evidence, Prayuth Poowaruttanawiwit, Patsanan Kulla, Naveeya Pakpoomkamonlert

The Thai Journal of Pharmaceutical Sciences

Background: Burn injuries remain a major therapeutic challenge, with conventional treatments often failing to achieve complete functional skin regeneration. Stem cell-based interventions, including mesenchymal stem cells (MSCs) and exosome derivatives, have demonstrated regenerative and immunomodulatory potential, yet their translation to clinical practice remains limited.
Objectives: To systematically evaluate the efficacy and safety of stem cell-based therapies for burn wound healing across pre-clinical and clinical studies.
Materials and Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines, four databases (PubMed, Embase, Scopus, and Cochrane) were searched through April 2025. Eligible studies included randomized controlled trials and controlled pre-clinical …

Characteristics Of Drug-Related Problems And The Impact Of Pharmacist Interventions On Hospital Drug Costs In The Medical Intensive Care Unit, Sirima Sitaruno, Wanrada Binyala, Pattama Phetsuk, Nisrin Ni-Ngoh, Worakarn Nukong, Asama Saiwaree, Nawaporn Assanangkornchai, Tanatape Wanishayakorn

The Thai Journal of Pharmaceutical Sciences

Background: Pharmaceutical care activities have been reported to enhance treatment outcomes and cost-effectiveness in critically ill patients. However, relevant and timely data on this topic are still lacking in Thailand.
Objectives: The objective of the study is to investigate the characteristics of drug-related problems (DRPs) identified during pharmaceutical care activities at the medical intensive care unit (MICU) of a tertiary care teaching hospital in Thailand. In addition, we aimed to quantify the impact of pharmacist interventions on hospital drug costs.
Materials and Methods: DRPs identified during pharmaceutical care activities over 3 years were reviewed and classified by the Pharmaceutical Care …

Optimization Of Solvent Extraction For Polyphenols And Antioxidant Activity From Zanthoxylum Acanthopodium Leaves Using Simplex Centroid Design, Waras Nurcholis, Indah Z. Septiawati, Roni Kartiman, Surya Diantina

The Thai Journal of Pharmaceutical Sciences

Background: Zanthoxylum acanthopodium DC., locally known as andaliman, is an indigenous spice from North Sumatra, Indonesia, recognized for its high antioxidant potential. Despite its bioactive richness, optimization of solvent extraction for phenolic and flavonoid compounds from its leaves remains underexplored, even though these compounds are valuable for food and pharmaceutical applications. The use of solvents such as acetone in analytical extraction contexts is acceptable; however, further purification steps would be required for applications in food and pharmaceutical products.
Objectives: The main objective of this study was to optimize solvent combinations – comprising water, ethanol, and acetone – to maximize the …

Pharmacognostic Analysis And Thin-Layer Chromatographic Study Of The Thai Antipyretic Herbal Formula Khiao-Bencha-Khan, Sirinapa Chaisri, Tassanee Paraput, Pravit Akarasereenont, Pinpat Tripatara

The Thai Journal of Pharmaceutical Sciences

Background: Khiao-bencha-khan formula (KBF) is an herbal formula recorded in Thai scriptures and used to treat fever, including exanthematous fever, and aphthous ulcers. It consists of Limnophila rugosa (Roth) Merr., Bacopa monnieri (L.) Wettst., Gossypium arboreum L., Pogostemon cablin (Blanco) Benth., Eupatorium japonicum L., and Justicia gendarussa Burm.f.
Objectives: This study aimed to identify the pharmacognostic and chemical profiles of the herbal components found in KBF.
Methods: All authentic plant materials were collected, and samples were prepared under Pharmaceutical Inspection Co-operation Scheme/good manufacturing practice guidelines. The materials were identified using macroscopic, microscopic, and thin-layer chromatography (TLC) methods.
Results: Microscopic analysis …