Medicine and Health Sciences Commons^™

Improving Functional Electrical Stimulation Prescription For Persons With Multiple Sclerosis: A Case Series, Shahla Hosseini, Kimberly Bigelow, Nick Padgett, Robert Campbell, Lauren Boland, Skylar Forsberg, Brett Weaver, Kurt Jackson

University of Dayton Doctor of Physical Therapy Annual Research Symposium

No abstract provided.

The Effects Of Yoga On The Symptoms Of Perimenopause And Menopause: A Randomized Control Trial, Wendy Chorny, Betsy Donahoe-Fillmore, Brenlyn Rostad, Olivia Miller, Summer Rivas, Andrea Heitkamp, Cassidy Albers, Kennedi Gephart, Mary Fisher

University of Dayton Doctor of Physical Therapy Annual Research Symposium

No abstract provided.

A Tennis Ball Necklace As Simple Feedback To Effectively Reduce Impact Kinetics During Running, Kevin Sheehan, Matthew Minard, Andrew Clark, Jason Clingenpeel, Morgan Gigandet, Nicolas Love, Madison Scott, Joaquin Barrios

University of Dayton Doctor of Physical Therapy Annual Research Symposium

No abstract provided.

Determining The Concurrent And Predictive Validity Of The Repetitive Step Test In Individuals With Parkinson’S Disease, Harold Merriman, Kurt Jackson, Kyle Arrowood, Kaylee Virag

University of Dayton Doctor of Physical Therapy Annual Research Symposium

No abstract provided.

Split-Squat Lower Limb Biomechanics In Individuals With And Without Chronic Ankle Instability, Joaquin Barrios, Eva Carbone, Matt Cesario, Marshall Flynn, Danielle Updike

University of Dayton Doctor of Physical Therapy Annual Research Symposium

No abstract provided.

Soft Tissue Mobilization Versus Hold-Relax Stretching On Wrist Extensor Tendon Stiffness In Tennis Players, Brendan Burck, Adina Taylor, Cody Pohlman, Andrew Traven, Harold Merriman, Joseph Day

University of Dayton Doctor of Physical Therapy Annual Research Symposium

No abstract provided.

Perspective On Speech Therapy, Aac Devices, And Community Support: A Case Study Of A Caregiver Of An Adult With Down Syndrome, Ella Harris

Honors College Theses

For someone with a disability such as Down syndrome (DS), they often present with deficits in speech and language. These individuals typically require a caregiver for their physical, mental, and social needs, and their caregiver also often serves as their primary communication partner. This study explored caregiver perspectives on how they facilitate communication including their experiences with speech therapy services, augmentative and alternative communication, and community communication supports. A caregiver of an adult with DS participated in a structured interview to discuss their experiences as a caregiver for an individual with complex communication needs. The data from the interview was …

Targeted Skin Cancer Education Improves Agricultural Workers' Safe Sun Practices And Knowledge In South Dakota: A Farm Show Survey, Leah Naasz, Kianna Thelen, Candace Zeigler

Scholarship Pathways Program

Targeted Skin Cancer Education Improves Agricultural Workers' Safe Sun Practices and Knowledge in South Dakota: A Farm Show Survey

Leah Naasz, MD | Candace Zeigler, MD

Background: Agricultural workers are at increased risk for skin cancer due to prolonged ultraviolet (UV) exposure, yet many underutilize sun protection. Brief, community-based educational interventions may improve knowledge and preventive behaviors.

Objective: To provide a targeted skin cancer educational session to increase awareness and promote sun protection behaviors among agricultural workers in South Dakota.

Methods: Twenty agricultural workers attending the Vermillion and Sioux Falls Farm Shows participated in a pre- and post-educational survey. Inclusion …

Program Development And Implementation Of A Sensory-Based Self Regulation Curriculum For Adults With Down Syndrome At Gigi’S Playhouse, Grace Blair

OTD Capstone Projects

This doctoral capstone project was completed through partnership with Gigi’s Playhouse Nashville, a non-profit organization offering free programming and services to individuals of all ages with Down syndrome and their families. The goal of this project was to develop and implement an educational curriculum for adult education programs focused on daily life skills, money management, physical health, self confidence, and a variety of other topics. A secondary focus of this project was to support sensory regulation in individuals with Down syndrome to promote overall health and participation. The results were physical and digital materials to be used for future adult …

Patient Reported Outcome Measure Use In Heart Transplant Care, Nichole Côté

Doctoral Projects

Despite growing evidence supporting Patient-Reported Outcome Measures (PROMs) in chronic disease management, no consistent application exists within the international heart transplant community. This Doctor of Nursing Practice project implemented the Kansas City Cardiomyopathy Questionnaire-12 (KCCQ-12) as a PROM within the a large volume heart transplant clinic, evaluating workflow feasibility, the association between Overall Summary Scores (OSS) and visit length, and clinician perceptions of PROM use. The KCCQ-12 was administered via a mobile health application with automated distribution. Workflow integration was assessed by calculating the percentage of scheduled visits with completed PROM documentation. Visit length was measured using electronic medical record …

Cellular And Molecular Basis Of Pfcoronin Function In Artemisinin Resistance In Plasmodium Falciparum, Imran Ullah, Eva S Istvan, Et Al.

2020-Current year OA Pubs

Artemisinin combination therapies are central to malaria control, but their efficacy is threatened by the emergence of resistant Plasmodium falciparum strains. While the role of Pfkelch13 mutations is well established, mutations in Pfcoronin have also been implicated in treatment failure, revealing layers of resistance complexity. Here, we define the cellular mechanism of Pfcoronin‑mediated artemisinin resistance. PfCoronin interacts with PfActin and localizes to the parasite plasma membrane, the digestive vacuole membrane, and small vesicles containing host cell material. Mutations in PfCoronin disrupt its localization and perturb PfActin homeostasis, altering the distribution of ring‑stage morphologies, including a reduced proportion of parasites adopting …

Examining The Rural Workforce: Comparing Admissions Strategies And Training Pathways In U.S. Medical And Dental Education, Charolyn A. Harris

Honors Theses

Access to healthcare in rural and underserved communities remains a significant challenge in the United States, particularly in dental care, where workforce shortages are more pronounced. This study examines how medical and dental education programs develop rural healthcare providers, focusing on admissions strategies and training pathways. Using a structured scoping review and secondary data analysis, this research compares how each field incorporates known predictors of rural practice, such as rural background and training experiences, into workforce pipeline development. Findings indicate that while both medical and dental education recognize rural background as a strong predictor of rural practice, medical education more …

Neuroprotective Effects Of Estradiol And Genistein And Interactions With Aromatase Inhibitions Post Cerebellar Lesion In Male Zebra Finches, Grace E. Thompson, Anthony P. Irovic

Honors Theses

Across vertebrates, peripheral and brain-derived estradiol (E₂) promotes neuroplasticity. After injury, E₂ can be derived locally from testosterone via aromatase (AROM), an enzyme that is upregulated in glia at the site of neural injury. E₂disrupts testicular function and elevates cancer and stroke risk, primarily via binding to estrogen receptor alpha (ER α). Genistein (GEN), a phytoestrogen, is similar to E₂ but binds preferentially to estrogen receptor beta (ER β). It may offer neuroprotection without adverse effects of E₂. We used adult male zebra finches (ZF) to model neuroprotective effects of E_{2 …}

Rational Design And Efficacy Evaluation Of A Novel Solid Dispersion-Based Bempedoic Acid–Ezetimibe Fixed-Dose Combination Tablet Versus Nexlizet®, Mohamed A. Heikal, Wael Ali, Mahmoud A. Mahdy, Eman Gomaa

Nanotechnology Research Centre

Background/Objectives: For hyperlipidemic patients with statin resistance, a fixed-dose combination of a non-statin drug such as ezetimibe (EZT) and bempedoic acid (BA) provides a significant benefit. Although both drugs exhibit poor aqueous solubility, the oral bioavailability of EZT is more critically limited by dissolution, whereas BA maintains adequate absorption due to its high intestinal permeability. With regard to the reference product, Nexlizet® (180/10 mg), our study focused on developing a novel tablet with superior in vitro performance without incorporating sodium lauryl sulfate (SLS), as it may potentially alter BA absorption. Methods: The solid dispersion technique (co-precipitation) was applied using the …

A Transgenerational Analysis Of Factors Influencing Fertility Among Jamaican Men, Shanique Deniellia Essuman

Walden Dissertations and Doctoral Studies

No abstract provided.

Expertise First: Reflections On Informal Artificial Intelligence Mentoring In An Asynchronous Nursing Faculty Community, Anna Liza D. Villena Phd, Rn, Fnp-Bc

Journal of Online Mentoring

The integration of generative artificial intelligence (AI) into higher education has arrived faster than the support structures designed to help faculty navigate it. This article reflects on one faculty member’s experience providing informal AI integration mentoring to nursing colleagues at Walden University, a fully asynchronous online graduate nursing program, where clinician-educators with deep disciplinary expertise often struggled to recognize that expertise as an asset in their interactions with AI tools.

Drawing on Rogers’ (2003) diffusion of innovations theory, the article describes the mentoring approach that emerged from practice, the central insight that faculty are not failing to integrate AI because …

I Am God's Masterpiece: Ministry For Adults With Idd, Kerrigan J. Creech

Occupational Therapy Doctorate Capstone Posters

Executive Summary 

My capstone Accreditation Council for Occupational Therapy Education (ACOTE) focus area included program development, with additional focus on education, advocacy, and leadership. For my Applied Leadership Experience (ALE), I worked with three other occupational therapy graduate students to develop and implement an inclusive Vacation Bible School (VBS) for adults with disabilities at Parkway Ministries. The purpose and overall goal of the project was to increase opportunities for adults with disabilities to participate in an inclusive Vacation Bible School through individualized supports and activity adaptations.

A needs assessment and SWOT analysis were completed and revealed that adults with disabilities …

Systemic Α₂-Agonist Use And Lower Hazard Of Glaucoma Compared With Β-Blockers: A Cohort Study, Ibrahim Abboud, Amin Z. Khudari, Abdelaziz Abdelaal, Amr Almobayed, Subhi J. Al'aref, Jonathan S. Myers, Richard K. Lee, Abdelrahman M. Elhusseiny

Wills Eye Hospital Papers

OBJECTIVE: Systemic antihypertensive medications may influence glaucoma-related outcomes through intraocular pressure-dependent and vascular mechanisms. While topical α₂-agonists are established glaucoma therapies, the association between systemic α₂-agonists and glaucoma hazard remains unexamined; we compared their hazard with systemic β-blockers in adults with hypertension.

METHODS AND ANALYSIS: We conducted a multicentre retrospective cohort study using deidentified electronic health records. Adults aged ≥40 years with hypertension and chronic exposure to systemic α₂-agonists or β-blockers were included. Patients with pre-existing ocular hypertension (OHT), primary open-angle glaucoma (POAG), concomitant comparator use, or inadequate ophthalmic follow-up were excluded. We balanced cohorts using propensity score matching (PSM) …

Illness Perception, Depression, And Anxiety Among Middle-Aged Adults With End-Stage Chronic Kidney Disease, Zioleyda Soto

Walden Dissertations and Doctoral Studies

No abstract provided.

Staff Education On The Phq-9 Tool And Its Use, Claudine Agwi Mbah

Walden Dissertations and Doctoral Studies

No abstract provided.

Staff Education To Improve Gad-7 Screening For Generalized Anxiety Disorder In Outpatient Behavioral Health Settings, Senami Olubunmi Edalere-Lukula

Walden Dissertations and Doctoral Studies

No abstract provided.

What Are The Specific Parameters Of Cold-Water Immersion On Its Positive Effects On Recovery And Sleep In The Physically Active Population?, Landyn L. James, Jay Albrecht, Dawn Hammerschmidt

Dissertations, Theses, and Projects

Cold-water immersion (CWI) is widely used in athletic and rehabilitative settings to enhance post‑exercise recovery, yet optimal treatment parameters remain inconsistent across clinical practice. Physically active individuals frequently seek recovery strategies that improve muscle function and sleep quality, creating a need to evaluate the evidence supporting specific CWI protocols. Focused Clinical Question: The purpose of this critically appraised topic (CAT) was to determine which temperature and duration parameters of CWI most effectively improve muscle recovery and sleep in physically active populations. A focused clinical question was developed using the PICO framework. Search Strategies: Systematic reviews and meta-analyses were identified through …

Comparative Behavioral Impacts Of Neuroactive Pharmaceuticals On Crayfish Locomotion, Grace Elizabeth Smith

Masters Theses

Pharmaceuticals are increasingly recognized as contaminants of concern in aquatic ecosystems, often entering waterways due to incomplete removal by wastewater treatment plants. Despite frequent detection, the effects of these compounds on non-target, neurochemically sensitive organisms such as crayfish remains underexplored. Gabapentin, an anticonvulsant that binds to presynaptic voltage-gated calcium channels and reduces excitatory neurotransmitter release, is one such emerging contaminant. Given crayfish’s ecological importance and sensitivity to neuroactive substances, exposure to gabapentin may disrupt key behaviors such as locomotion. To place gabapentin’s effects in context, we also examined escitalopram (Lexapro), a selective serotonin reuptake inhibitor that elevates synaptic 5-HT, and …

Machine Learning-Based Prediction Of Proximal Junctional Pathology After Adult Spinal Deformity Surgery: A Systematic Review And Diagnostic Test Accuracy Meta-Analysis, Shaan Patel, Shiva A. Nischal, Yi Hein Chai, Kush M. Kale, Kevin Hines, Joshua Pelta-Heller, Jack Jallo, James S. Harrop, Srinivas K. Prasad

Department of Neurosurgery Faculty Papers

BACKGROUND: Proximal junctional kyphosis (PJK) and failure (PJF) remain challenging and incompletely predictable adverse event following adult spinal deformity (ASD) surgery. Machine learning (ML) models have been proposed to improve risk stratification, but performance varies and clinical applicability remains uncertain. A systematic review and diagnostic test accuracy meta-analysis was performed to synthesize the predictive performance of ML-based models for proximal junctional pathology after ASD surgery.

METHODS: PubMed, Embase, and CENTRAL were searched from inception to February 2026. Studies developing or validating ML models predicting PJK or PJF following ASD surgery were included. Diagnostic performance was synthesized using random-effects models, pooling …

Determining The Relatedness Of Simian Varicella Virus Strains Using Polymerase Chain Reactions And Delta Herpesvirus-Dervied Primers, Ellyn M. Waits

Honors Theses

This study examines genetic variation among strains of Simian Varicella Virus (SVV) using genomic analysis. The primary goal of this experiment was to observe potential genomic differences among the Liverpool vervet virus (LVV), the Tsukuba herpesvirus, and the Delta herpesvirus (DHV) strains using primer sets developed from the fully sequenced DHV strain. SVV strains were initially cultivated in Vero cell cultures to begin viral propagation. Viral proliferation in these cell cultures enables DNA isolation via standard purification methods. The extracted viral DNA is subjected to polymerase chain reaction (PCR) amplification targeting specific regions of open reading frames (ORFs) in the …

Tale Of Two Pharmacies, Katie R. Jadin

Honors Theses

Community pharmacists are among the most accessible healthcare providers in the United States and play an increasingly important role in improving patient outcomes. This study observes whether geographical distance and demographic differences influence patient healthcare needs within community pharmacy settings. Communities in Wisconsin and Mississippi, approximately 800 miles apart, were compared due to differences in population demographics, socioeconomic factors, and disease burden.

A survey was distributed to community pharmacy employees, including pharmacists, pharmacy interns, and pharmacy technicians, to assess common disease states, medication patterns, pharmacy workload, and patients' barriers to care. Twelve responses were collected from pharmacy employees.

Despite the …

The Impact Of Hearts For The Homeless On Students At The University Of Mississippi, Ellie Menszer

Honors Theses

Hearts for Homeless (H4H) is an international organization that works to help one of the most vulnerable populations for cardiac disease, the homeless, due to the lack of access to health care and information. At the University of Mississippi, H4H is a registered student organization that volunteers weekly at the Oxford Community Market (OXCM) to provide free blood pressure screenings and heart health information. H4H helps the community while also providing students with hands-on patient care experience. The goal of this research is to determine how volunteering with H4H impacts students at the University of Mississippi. A literature review informed …

Synthesis Of Novel Tetrafluorinated Alcohols Through The Dimerization Of Difluoromethyl Ketones For Use In Drug Development, Abigail A. Ryan

Honors Theses

As the most electronegative element, fluorine has unique applications and properties. The carbon-fluorine bond is known to be one of the strongest bonds in organic chemistry. As a result of fluorine’s high C–F bond strength, fluorine chemistry has become an interdisciplinary field of chemistry, pharmacy, physics, geology, and ecology. In pharmaceuticals for example, current estimates indicate that about 15–20% of FDA approved small-molecule drugs include at least one fluorine atom. The incorporation of fluorine atoms into organic molecules has become a powerful strategy in modern drug development, as fluorination can enhance metabolic stability, lipophilicity, and biological activity. Despite these advantages, …

Celiac Plexus Radiosurgery For Retroperitoneal Pain In Advanced Cancer: A Pre-Specified Secondary Analysis Of Health-Related Quality Of Life In A Phase Ii Single-Arm Trial, Aisling Barry, Ronen Fluss, Laura Dawson, David Hausner, Michael Buckstein, Talia Golin, Laurence Freedman, Marcin Miszczyk, Dayssy Diazpardo, Artur Aguiar, Dror Limon, Raphael Pfeffer, Moaz Ben-Ayun, Liat Hammer, Ziv Symon, Ofir Morag, Gali Jacobson, Adam Dicker, Jerzy Wydmanski, Camilla Zimmermann, Yaacov Lawrence

Department of Radiation Oncology Faculty Papers

BACKGROUND: Retroperitoneal pain syndrome seen in pancreatic cancer is a major clinical challenge. Celiac plexus radiosurgery, a new palliative technique for retroperitoneal pain syndrome, decreased pain levels in a phase II study. Here Health-Related Quality of Life (HRQOL) outcomes are reported.

METHODS: Evaluable patients, who were enrolled between January 2018 and December 2021, in an international single-arm Phase II ethics-approved study (NCT03323489), were included. The pre-specified secondary endpoint-change in HRQOL from baseline to 3- and 6-weeks post-treatment, was measured by the Functional Assessment of Cancer Therapy - Hepatobiliary (FACT-Hep) version 4 questionnaire. Mean change was deemed clinically significant (CS) if …

Community Composition Of Antibiotic-Resistant Bacteria On The Mississippi Gulf Coast, Marisa Martin, Colin Jackson

Honors Theses

The Mississippi Gulf Coast is an important resource for transportation, economic development, and recreation. Given its economic and cultural importance, it is crucial to maintain clean and safe conditions along the coast for public health, but other than routine beach monitoring, few studies have examined microbial contamination of coastal waters in this region. This study aimed to determine the quantity, composition, and distribution of bacteria resistant to six different antibiotics (Vancomycin, Kanamycin, Tetracycline, Ciprofloxacin, Erythromycin, or Amoxicillin) in seawater at seven public beaches along the Mississippi Gulf Coast. No bacteria resistant to Ciprofloxacin were detected, and bacteria resistant to Kanamycin …