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Articles 4261 - 4290 of 15161
Full-Text Articles in Medicine and Health Sciences
Enhancing Independence: A Home Environmental Safety Program For Stroke Survivors, Ka'iulani-Joy Genevieve Conlu
Enhancing Independence: A Home Environmental Safety Program For Stroke Survivors, Ka'iulani-Joy Genevieve Conlu
UNLV Theses, Dissertations, Professional Papers, and Capstones
Background: Stroke is a common cause of physical limitations, leading to decreased independence and participation in daily activities. Individuals post-stroke transitioning from inpatient to outpatient care typically do not receive in-person home safety recommendations to decrease environmental challenges and improve overall well-being. Methods: Participants were recruited conveniently during the inpatient and outpatient care process at Post Acute Medical (PAM) Health Rehabilitation Hospital of Henderson. The Home Falls and Accidents Screening Tool (HOME FAST) was administered to identify environmental hazards and to guide individualized home safety recommendations. Participants will complete a questionnaire before and after the program within 14 weeks to …
Inclusiveness With Sensory Maps; Enhancing Engagement In A Children's Museum, Victoria E. Davila
Inclusiveness With Sensory Maps; Enhancing Engagement In A Children's Museum, Victoria E. Davila
UNLV Theses, Dissertations, Professional Papers, and Capstones
Sensory processing challenges can affect a child’s ability to engage in play, especially when participating in community activities. When a child feels overwhelmed by sensory features in an environment, such as noise or bright lights in a community space, they may experience sensory overload. Caregivers often observe this behavior but may not have access to resources to help their child navigate these challenges. This capstone project aimed to implement a program development initiative at the Discovery Children’s Museum focused on developing sensory-inclusive resources for caregivers visiting the museum with a child. The role of occupational therapy in this project is …
The Lotus Project: An Occupation-Based Online Module To Support Healthy Matrescence, Virginia Genato
The Lotus Project: An Occupation-Based Online Module To Support Healthy Matrescence, Virginia Genato
UNLV Theses, Dissertations, Professional Papers, and Capstones
Becoming a mother is a meaningful life event that occurs amid complex physical, psychological, and social changes. During this period, individuals undergo an occupational role transition as they assume new caregiver responsibilities while navigating contextual demands. The ease of this transition influences overall maternal adjustment. The dominant sociocultural model of intensive mothering promotes child-centered caregiving, often at the expense of maternal well-being and adjustment. Efforts to meet these expectations may disrupt an individual’s transition into motherhood and place them at risk for developing postpartum mental health challenges.
The concept of matrescence provides a developmental framework that views motherhood as an …
Promoting Classroom Management Through Elementary Teacher Education On Movement-Based Social-Emotional Learning, Daija Renee Georgette
Promoting Classroom Management Through Elementary Teacher Education On Movement-Based Social-Emotional Learning, Daija Renee Georgette
UNLV Theses, Dissertations, Professional Papers, and Capstones
This doctoral capstone project addressed a knowledge gap among K–5 th–grade teachers at Cornerstone Christian Academy (CCA) regarding the purpose, benefits, and educational value of movement-based brain breaks. Although CCA currently incorporates social–emotional learning (SEL) frameworks such as the Zones of Regulation, teachers have received limited training on how structured movement opportunities can enhance student engagement, attention, and regulation. This program aimed to strengthen teachers’ understanding and confidence by providing a series of evidence-informed workshops that explored the connections among movement, self-regulation, and classroom management.
The project consisted of orientation, teacher recruitment, needs assessment, workshop development, and program delivery over …
Establishing A Comprehensive Framework For Sfrt Lattice Treatments: Optimization, Planning, And Clinical Evaluation, Gregory M. Gill
Establishing A Comprehensive Framework For Sfrt Lattice Treatments: Optimization, Planning, And Clinical Evaluation, Gregory M. Gill
UNLV Theses, Dissertations, Professional Papers, and Capstones
Spatially fractionated radiation therapy (SFRT) using lattice radiotherapy (LRT) has emerged as a promising treatment technique for bulky, nonresectable tumors by delivering spatially heterogeneous dose distributions consisting of high-dose vertices embedded within lower-dose regions. Although early clinical experiences have demonstrated potential therapeutic benefit, widespread clinical implementation of LRT remains limited due to the absence of standardized treatment planning workflows, consistent optimization strategies, and clearly defined evaluation metrics for heterogeneous dose distributions. The objective of this study is to develop and evaluate a structured framework to support efficient, reproducible, and safe clinical implementation of LRT.
To address these challenges, a comprehensive …
The Exploration Of Leisure Occupations For Older Adults, Chloe Jisoo Kang
The Exploration Of Leisure Occupations For Older Adults, Chloe Jisoo Kang
UNLV Theses, Dissertations, Professional Papers, and Capstones
Introduction: This capstone project involved the development and implementation of a community-based program for the exploration of leisure occupations for older adults. The program aimed to increase the life satisfaction and occupational balance of participants. A manualized program was created for the capstone site for potential continuation of the program.
Methods: The program was developed with the support of evidence-based research and the Occupational Therapy Practice Framework (OTPF-4). Two-hour events were held once a week for four weeks in a community area of the senior living community. A modified version of the Occupational Balance Questionnaire (OBQ11) and the Satisfaction with …
Feasibility Of High-Intensity Training (Hit) For Academic Engagement In Young Adult Women, Raleah Tenorio Kastner
Feasibility Of High-Intensity Training (Hit) For Academic Engagement In Young Adult Women, Raleah Tenorio Kastner
UNLV Theses, Dissertations, Professional Papers, and Capstones
Purpose: This feasibility study aimed to identify the impact of a high-intensity training (HIT) exercise protocol on healthy behaviors related to academics to decrease stress levels and enhance academic engagement and overall quality of life in young adult female students, measured by a modified version of the National Survey of Student Engagement (NSSE) and the Occupational Experience Profile (OEP).
Methodology: One young adult female student enrolled at UNLV who is 18-25 years old was recruited via convenience sampling to engage in a 12-session HIT exercise program, developed by a certified personal trainer and licensed occupational therapist, with the participant’s target …
A Comparison Of Changes In Vertical Cephalometric Measurements In Patients Treated With Invisalign And Traditional Fixed Orthodontic Appliances: A Retrospective Study, Shayna Mesko
UNLV Theses, Dissertations, Professional Papers, and Capstones
Background: Since their introduction into the field, clear aligners have significantly grown in popularity in orthodontics as they offer enhanced esthetics, improved oral hygiene, and patient comfort. Clear aligners have allowed clinicians to simulate treatment outcomes, streamline treatment with reduced office visits, control force and movement per tray, and provide more precise control of focal tooth movements. This can enhance efficiency in achieving specific and very finite orthodontic goals. Since their inception, clear aligners have evolved from only accomplishing simple tooth movements to achieving more complex and comprehensive mechanics. While they have significantly advanced, there are still limitations in efficacy …
Postpartum Depression Protocols In A Neonatal Intensive Care Unit: Benefits And Outcomes, Myrnnda Miller
Postpartum Depression Protocols In A Neonatal Intensive Care Unit: Benefits And Outcomes, Myrnnda Miller
UNLV Theses, Dissertations, Professional Papers, and Capstones
This capstone project aimed to reduce postpartum depression symptoms in mothers with infants admitted to the University Medical Center (UMC) of Southern Nevada’s neonatal intensive care unit (NICU) by integrating early screening with occupation-based, trauma-informed support. The intervention combined the Edinburgh Postnatal Depression Scale (EPDS) for early detection with occupational therapy–facilitated maternal support sessions, providing emotional validation, education, and strategies for coping and parent–infant bonding. Guided by Trauma-Informed Care and Backwards Design frameworks, the project prioritized maternal safety, empowerment, and confidence. A paired sample t-test was conducted to compare pre and posttest EPDS scores and showed that the participant’s EPDS …
Supporting Staff Social-Emotional Learning Through An After-School Program, Alexis Monique Molina
Supporting Staff Social-Emotional Learning Through An After-School Program, Alexis Monique Molina
UNLV Theses, Dissertations, Professional Papers, and Capstones
This doctoral capstone project aimed to develop and implement an occupational therapy- informed social-emotional learning (SEL) training program for after-school staff at the Hollywood Recreation Center in Las Vegas, Nevada. The project addressed a critical gap in the skills and competence of staff needed to manage emotional and behavioral challenges in community-based youth programs. Guided by the Person-Environment-Occupation (PEO) model, adult learning theory, and the Collaborative for Academic, Social, and Emotional Learning (CASEL) framework, the fourteen-week program incorporated weekly lessons to enhance self-awareness, emotional regulation, and relational competence among staff. Through interactive lessons, reflection promotion, and feedback surveys, participants engaged …
A Warm Welcome: Developing Strategies And Tactics To Address The Resolution Of Neonatal Hypothermia, Sarah J. Musovski
A Warm Welcome: Developing Strategies And Tactics To Address The Resolution Of Neonatal Hypothermia, Sarah J. Musovski
UNLV Theses, Dissertations, Professional Papers, and Capstones
Purpose/Aim:
This project aimed to promote the use of a standardized checklist for newborn care that incorporated evidence-based practices. The goal was to maintain newborn temperatures in the normothermic range of 36.5–37.5 °C while receiving care in the hospital setting.
Purpose/Aim:
This project aimed to promote the use of a standardized checklist for newborn care that incorporated evidence-based practices. The goal was to maintain newborn temperatures in the normothermic range of 36.5–37.5 °C while receiving care in the hospital setting.
Description of the Undertaking/Best Practice:
The checklist that was provided included a series of evidence-based actions to promote and advance …
Addressing Sleep Health In The Fire Service: A Sleep Hygiene Education Program, Alyssa Elizabeth Neal
Addressing Sleep Health In The Fire Service: A Sleep Hygiene Education Program, Alyssa Elizabeth Neal
UNLV Theses, Dissertations, Professional Papers, and Capstones
This capstone project implemented an occupational therapy sleep hygiene program tailored to the unique occupational demands of Las Vegas Fire and Rescue (LVFR) firefighters. Guided by the Occupational Adaptation theory and the CALMS Framework, this project conceptualized sleep as a meaningful occupation essential to health, safety, and functional performance. The project’s aim was to assess the feasibility of a sleep hygiene program designed for the fire service using standardized measures, including the Sleep Hygiene Index. The methodology incorporated a structured educational session focused on educating firefighters on the importance of sleep, modifying routines and environments to support restorative sleep, implementing …
The Impact Of Language-Concordant Diagnosis Education On Discharge Readiness For Spanish-Speaking Patients, Jorge Noel Perdomo Rodriguez
The Impact Of Language-Concordant Diagnosis Education On Discharge Readiness For Spanish-Speaking Patients, Jorge Noel Perdomo Rodriguez
UNLV Theses, Dissertations, Professional Papers, and Capstones
Background: Current language service practices fail to meet the needs of Spanish-speaking patients with Limited English Proficiency (LEP) resulting in decreased satisfaction with care, understanding of diagnosis education, and increased risk of post-discharge health disparities. Language-concordant care has been found to improve patient satisfaction with care and increase quality of transition from hospital to home. Research on language-concordant OT care is scarce and current studies suggest that language discordance leads to decreased quality of OT care for Spanish speakers. Problem: Language discordance leads to poor understanding of OT’s role and decreases patient-centered care for Spanish-speaking patients. Purpose: This project aimed …
Empowering Educators: Transforming Online Classrooms Through Interactive Training, Jodie Peterson
Empowering Educators: Transforming Online Classrooms Through Interactive Training, Jodie Peterson
UNLV Theses, Dissertations, Professional Papers, and Capstones
Faculty teaching in online nursing programs must continually adapt to evolving educational technologies and pedagogical methods to ensure high-quality learning experiences. However, nursing faculty may lack the resources, knowledge, and skills needed to effectively implement technology-driven, learner-centered strategies that facilitate engagement in virtual classrooms. Supporting faculty development in available interactive technologies is essential to enhance instructional effectiveness and improve student engagement and learning outcomes. This Doctor of Nursing Practice project focuses on strengthening faculty knowledge and competence in using interactive, learner-centered strategies in online education. The project was implemented within a southern Nevada university’s school of nursing and provided an …
Correlation Between Maxillary Sinus Volume And Maxillomandibular Size, Position, And Dental Occlusion: A Cbct Retrospective Study, Philip Villanueva Punzalan
Correlation Between Maxillary Sinus Volume And Maxillomandibular Size, Position, And Dental Occlusion: A Cbct Retrospective Study, Philip Villanueva Punzalan
UNLV Theses, Dissertations, Professional Papers, and Capstones
This investigation used cone beam computed tomography (CBCT) based three dimensional imaging to evaluate correlations between maxillary sinus volume and maxillomandibular skeletal size, position, and dental occlusion in an adult orthodontic population. A retrospective sample of 107 pretreatment CBCT scans (40 males and 67 females), aged 18–59 years, was analyzed. Right and left maxillary sinuses were segmented independently using semi-automatic volumetric segmentation in ITK-SNAP software, and total sinus volume was calculated in cubic millimeters (mm³). Linear and angular skeletal measurements of the maxilla and mandible were obtained using Anatomage TxSTUDIOViewer application software. Patients were categorized according to anteroposterior (A-P) skeletal …
Psychological Impact Of Nexus Program On Persons Living With Mild Dementia, Kaleigh Gailynn Quinlan
Psychological Impact Of Nexus Program On Persons Living With Mild Dementia, Kaleigh Gailynn Quinlan
UNLV Theses, Dissertations, Professional Papers, and Capstones
Objective: Dementia is a global health concern due to the rapidly growing aging population (WHO, 2023). A wealth of evidence exists to support the notion that lifestyle interventions not only slow cognitive decline but improve cognition (Ngandu et al., 2015; Rosenberg et al.., 2018; Meng et al., 2022). However, there is a distinct lack of qualitative evidence examining the experience of being in a lifestyle redesign program. Lifestyle interventions require a large overhaul of an individual’s habits and performance patterns, and as such, there must be a subjective experience attached. Methodology: Through convenience sampling of the residents participating in the …
Identifying Well-Being Factors For At-Risk Young Adult Women: A Scoping Review, Carolina A. Quinonez
Identifying Well-Being Factors For At-Risk Young Adult Women: A Scoping Review, Carolina A. Quinonez
UNLV Theses, Dissertations, Professional Papers, and Capstones
Purpose
This scoping review has systematically explored and mapped the range of literature that pertains to the influences of well-being for at-risk young adult women, to inform occupational therapy practice, guide future research, and enhance the knowledge of holistic well-being.
Methodology
Four online databases, including Google Scholar, were searched to identify publications, in the past 20 years, on relevant data for at-risk women and their well-being levels. Data was tracked using a PRISMA-ScR diagram with guidance from JBI protocol.
Results
There were 39 studies that met all the inclusion criteria. The studies were categorized into the types of well-being and …
Expanding Neurological Interventions: An Aquatic-Based Occupational Therapy Toolkit For Inpatient Rehabilitation, Kate Jannelle Rye
Expanding Neurological Interventions: An Aquatic-Based Occupational Therapy Toolkit For Inpatient Rehabilitation, Kate Jannelle Rye
UNLV Theses, Dissertations, Professional Papers, and Capstones
Objective: The objective of this project was to develop an evidence-informed aquatic therapy toolkit aimed at improving occupational therapy practitioners’ self-efficacy in planning aquatic interventions for individuals with neurological injuries.
Methods: This project utilized a quality improvement approach, involving the development of a toolkit, an in-service educational training, and a hands-on skills session. Practitioner self-efficacy was measured using a modified General Self-Efficacy Scale, which was administered before and after the educational training and hands-on skills session. Guided reflections and feedback from occupational therapy practitioners were also utilized to evaluate self-efficacy and the applicability of the toolkit.
Outcomes: Participation in the …
Movement-Based Program To Support Quality Of Life For Adults With Down Syndrome, Jillian Sanalila
Movement-Based Program To Support Quality Of Life For Adults With Down Syndrome, Jillian Sanalila
UNLV Theses, Dissertations, Professional Papers, and Capstones
This doctoral project focused on the development, implementation, and evaluation of a community-based movement program designed to support quality of life (QoL) among adults with Down syndrome and other intellectual and developmental disabilities at GiGi’s Playhouse Las Vegas. Adults with Down syndrome often experience significant health and participation disparities that negatively impact quality of life. These disparities include reduced physical activity, limited opportunities for social engagement, and barriers to engagement in meaningful occupations. Grounded in occupational therapy principles, this project introduced a structured intervention integrating dance, Pilates, and yoga to promote physical, emotional, and social well-being. A program development design …
Efficacy Of The Dorsal Application Of Kinesiotape For Carpal Tunnel Syndrome On Sleep, Alyanna San Pedro
Efficacy Of The Dorsal Application Of Kinesiotape For Carpal Tunnel Syndrome On Sleep, Alyanna San Pedro
UNLV Theses, Dissertations, Professional Papers, and Capstones
Carpal tunnel syndrome (CTS) is a common upper-extremity condition among university students who frequently engage in prolonged computer and device use. CTS symptoms, specifically in nocturnal pain, tingling, and numbness, often disrupt sleep quality, which can lead to negative effects on daytime functioning and participation in meaningful occupations. Despite growing interest in conservative management strategies, there is limited research on the potential role of kinesiotape (KT) in addressing sleep-related symptoms of CTS. This study aims to examine changes in sleep quality, nocturnal symptoms severity, and participation in meaningful activities in university students experiencing mild to moderate CTS symptoms. Participants were …
Examining Demographic And Contextual Differences In Stress-Related Sport Interference Among U.S. Collegiate Sport Participants, Heather Tran
Examining Demographic And Contextual Differences In Stress-Related Sport Interference Among U.S. Collegiate Sport Participants, Heather Tran
UNLV Theses, Dissertations, Professional Papers, and Capstones
Collegiate athletes experience a range of stressors that may interfere with sport performance; however less is known about how stress-related sport interference varies across demographic groups and contexts. Guided by the transactional model of stress and coping, this study examined differences in stress-related sport interference by gender, race/ethnicity, and year in school, as well as across situational contexts (training, competition, and life outside of sport). Data were drawn from a secondary dataset of 288 collegiate sport participants who completed the Sport Interference Checklist (SIC). Independent samples t-test and analyses of variance (ANOVA) were used to examined demographic differences, and a …
Treatment And Recovery Of Mucoceles In Brass Musicians: The Performance Trap And Its Consequences, David D. Torres
Treatment And Recovery Of Mucoceles In Brass Musicians: The Performance Trap And Its Consequences, David D. Torres
UNLV Theses, Dissertations, Professional Papers, and Capstones
This dissertation examines the treatment and recovery of oral mucoceles in professional brass musicians through a qualitative case study combining personal narrative, semi-structured interviews, and analysis of medical and pedagogical literature. I interviewed four professional trumpet players who experienced mucoceles and lip trauma, and three medical professionals with relevant expertise. My own case serves as the primary study, documenting 15 years of scar tissue management following surgical excision and an immediate return to demanding performance. Medical literature treats mucocele excision as a routine procedure with recovery measured in weeks. Brass pedagogy literature assumes healthy lips and offers no guidance for …
Exploring A Boxing Community Exercise Porgram For Women With Parkinson's Disease, Emily Truong
Exploring A Boxing Community Exercise Porgram For Women With Parkinson's Disease, Emily Truong
UNLV Theses, Dissertations, Professional Papers, and Capstones
Objective: The purpose of this capstone project was to explore the lived experiences of 10 women with Parkinson’s disease (PD) who participate in the Rock Steady Boxing (RSB) program, an exercise community-based non-contact boxing program. Because women remain underrepresented in PD research and exercise-based interventions, this project aims to better understand how women perceive the physical, emotional, and social impacts of participating in RSB.
Methods: This qualitative case series included 10 women diagnosed with PD that participate in RSB at the Tony Cress Training Center. Data was collected through individual semi-structured interviews and audio recordings. Interviews were consented, transcribed verbatim, …
Development And Evaluation Of A Training Program On Pain Assessments For Pediatric Care Teams In Skilled Nursing Facilities, Rudy Velasquez-Correa
Development And Evaluation Of A Training Program On Pain Assessments For Pediatric Care Teams In Skilled Nursing Facilities, Rudy Velasquez-Correa
UNLV Theses, Dissertations, Professional Papers, and Capstones
This capstone project was a program development and quality improvement initiative at Silver State Pediatrics focused on improving consistency and confidence of pediatric care staff in assessing and documenting pain in children, particularly those who are non-speaking and medically complex. Although validated tools such as the Face, Legs, Activity, Cry, Consolability (FLACC), revised-FLACC (R-FLACC), and Non-communicating Children’s Pain Checklist-Revised (NCCPC-R) exists, inconsistent training and limited interdisciplinary communication have led to variability in clinical practice. This project involved implementing a brief, 20-30-minute interdisciplinary training session for nursing and rehabilitation staff on the use of validated pediatric pain assessment tools and collaborative …
Application Of Occupational Therapy Task-Oriented For Chronic Post-Stroke Rehabilitation: A Case Study, Gia Nghi Vu
Application Of Occupational Therapy Task-Oriented For Chronic Post-Stroke Rehabilitation: A Case Study, Gia Nghi Vu
UNLV Theses, Dissertations, Professional Papers, and Capstones
Stroke remains the leading cause of long-term disability, with persistent upper extremity (UE) impairment limiting engagement in daily tasks, reducing quality of life and contributing to learned non-use in the chronic stage among stroke survivors. The Occupational Therapy Task Oriented (OTTO) approach is proposed to optimize occupational performance through the use of meaningful, functional and highly individualized tasks that enable clients to fulfill their valued roles and participate in desired daily activities. The purpose of this capstone project was to advance clinical skills by applying the OTTO approach to examine its effect on occupational performance and UE motor function in …
Examining The Effects Of Tailored Ergonomic Interventions On Reducing Musculoskeletal Disorders For Taxi Drivers, Amal Youssouf
Examining The Effects Of Tailored Ergonomic Interventions On Reducing Musculoskeletal Disorders For Taxi Drivers, Amal Youssouf
UNLV Theses, Dissertations, Professional Papers, and Capstones
Taxi drivers are frequently exposed to prolonged sitting, whole-body vibration, limited rest opportunities, and psychosocial stressors, placing them at increased risk for musculoskeletal disorders (MSDs). This can be mitigated with the use of ergonomics, which changes one's environment to match an individual's needs within the context and demands of the job. Although ergonomics is a recognized area of occupational therapy (OT) practice, current research is limited to office-based or computer-related settings, leaving a gap in OT-led ergonomic interventions tailored for professional drivers. This capstone project aimed to determine whether OT-based ergonomic strategies, along with an ergonomic checklist as a guideline …
Proceedings Of The 18th Indonesian Occupational Medicine Update (Iomu) 2026 - Occupational Medicine Without Borders: Emerging Risks, Evolving Workforces, And Inclusive Collaboration, Indonesian Association Of Occupational Medicine Specialists (Perhimpunan Kedokteran Okupasi Indonesia / Perdoki)
Proceedings Of The 18th Indonesian Occupational Medicine Update (Iomu) 2026 - Occupational Medicine Without Borders: Emerging Risks, Evolving Workforces, And Inclusive Collaboration, Indonesian Association Of Occupational Medicine Specialists (Perhimpunan Kedokteran Okupasi Indonesia / Perdoki)
Occupational and Environmental Medicine Journal of Indonesia
This Supplemental Issue of the Occupational and Environmental Medicine Journal of Indonesia (OEMJI) compiles the scientific abstracts presented at the 18th Indonesian Occupational Medicine Update (IOMU) 2026, convened in Surabaya, Indonesia, from 15 to 17 May 2026. The IOMU has matured into the most prominent annual scientific platform of the Indonesian occupational medicine community, hosted by the Indonesian Association of Occupational Medicine Specialists (Perhimpunan Kedokteran Okupasi Indonesia / PERDOKI). Since its inception, the conference has served as a meeting point where clinicians, academics, industrial hygienists, regulators, employers, and worker representatives gather to translate emerging scientific evidence into …
Weighted Blankets: Implementation Of A Quality Improvement Pilot Project In The Neurosciences Intensive Care Unit, Anita Musafar
Weighted Blankets: Implementation Of A Quality Improvement Pilot Project In The Neurosciences Intensive Care Unit, Anita Musafar
Doctoral Projects
The weighted blanket quality improvement pilot project was implemented at Stanford Healthcare (SHC) to address the limited number of nonpharmacological interventions available for agitation management in the critical care setting. Patients within the Neurosciences ICU (NSICU) at SHC are clinically complex and uniquely vulnerable to experiencing agitation. The objectives of this initiative were to understand nurses' perceptions surrounding weighted blanket use in the critical care setting and assess whether there was a decrease in Richmond Agitation-Sedation Scale (RASS) scores with this intervention. From September 2025 to December 2025, the nurses within the NSICU implemented the use of weighted blankets for …
Longitudinal Changes In Cognition And Brain Imaging In Persons With Human Immunodeficiency Virus, James Kennedy, Sarah A Cooley, June Roman Fox, Kalen J Petersen, Elizabeth Westerhaus, Pat Reid, Linet Lopez, Beau M Ances
Longitudinal Changes In Cognition And Brain Imaging In Persons With Human Immunodeficiency Virus, James Kennedy, Sarah A Cooley, June Roman Fox, Kalen J Petersen, Elizabeth Westerhaus, Pat Reid, Linet Lopez, Beau M Ances
2020-Current year OA Pubs
BACKGROUND: As persons with human immunodeficiency virus (PWH) live longer, interactions between human immunodeficiency virus (HIV), aging, and structural brain integrity become increasingly vital for understanding cognitive disorders. This study analyzed the effects of aging, HIV serostatus, and viral load on cognition and brain volumes in a large cohort of persons without HIV (PWOH), PWH with undetectable virus (PWHU) (HIV RNA ≤50 copies/mL), and PWH with detectable virus (PHWD) (HIV RNA >50 copies/mL). Cross-sectional and longitudinal data were included.
METHODS: Cognitive composites (NPZ4) and brain volumes were obtained from 259 PWOH, 264 PWHU, and 84 PWHD with a total of …
Quantification Of Sarm1 Nadase Activity In Human Peripheral Blood Mononuclear Cells, Lila F Dabill, Ivana R Shen, Jennifer M Brazill, Alicia Neiner, Yo Sasaki, Erica L Scheller
Quantification Of Sarm1 Nadase Activity In Human Peripheral Blood Mononuclear Cells, Lila F Dabill, Ivana R Shen, Jennifer M Brazill, Alicia Neiner, Yo Sasaki, Erica L Scheller
2020-Current year OA Pubs
SARM1 (sterile α and TIR motif-containing protein-1) is an NADase enzyme that serves as the central executioner of Wallerian axon degeneration. Given this, SARM1 is of high interest as a candidate therapeutic target, and SARM1 inhibitors are currently in clinical trials for treatment of neurodegeneration. Beyond neuroscience, emerging studies reveal that SARM1 may also drive aspects of bone fragility, liver pathology, adipose expansion, and insulin resistance in metabolic disease. However, we lack methods to quantify SARM1 activation in humans to better define patients at high risk of SARM1-mediated tissue damage. Unlike neurons, peripheral blood mononuclear cells (PBMCs) represent an easily …