Medicine and Health Sciences Commons^™

Postpartum Depression: A National Crisis Calling For Federal Support, Sarah A. Stallsworth

Doctor of Nursing Practice Final Manuscripts

Postpartum depression (PPD) is the leading cause of maternal mortality in the United States, yet it remains significantly underdiagnosed and undertreated. Despite decades of research illuminating its prevalence and detrimental consequences, federal intervention has been limited.  States retain responsibility to address the issue and possess inconsistent and limited legislation.  The purpose of this paper is to propose adding PPD screening as a National Performance Measure (NPM) within the Title V Maternal and Child (MCH) block grant. MCH is a longstanding and resourceful program that provides states funds to address maternal mental health needs. This proposal suggests leveraging a PPD NPM …

O-Glcnacylation As A Metabolic Integrator In Cardiovascular Physiology And Disease, Saima Shakil Malik, Xinchun Pi, Liang Xie

Faculty, Staff and Students Publications

No abstract provided.

Targeted Suppression Of Spp1 Inhibits Tumor Invasion And Metastasis In Nrf2 Hyperactivated Cisplatin Resistant Hnscc, Mutsuki Kawabe, Sujuan Yang, Lorena I Gomez-Bolanos, Shiro Takamatsu, Sylvia Flores, Patricia D Castro, Tsung-You Tsai, Arisa Nishikawa Kaga, Kento Okamoto, Mitchell J Frederick, Vlad C Sandulache, Humam Kadara, Jeffrey N Myers, Abdullah A Osman

Faculty, Staff and Students Publications

Background: Cisplatin remains the standard systemic therapy for the definitive treatment of head and neck squamous cell carcinoma (HNSCC), however, resistance to cisplatin continues to be a major barrier to effective treatment, particularly in tumors with NRF2 hyperactivation. Recent studies identify secreted phosphoprotein 1 (SPP1/osteopontin) as a key NRF2 target frequently overexpressed in cancers, where it drives aggressive tumor behavior, metastasis, chemoresistance, and, in some cases, immune suppression. Our recent data highlight SPP1 as one of the top 10 NRF2-upregulated genes in cisplatin-resistant HNSCC. However, its specific role in therapy resistance and metastasis in HNSCC remains unclear. Here, we investigate …

Generalizability Of An Ai-Based Mammogram Risk Score (Mrs) For Breast Cancer Among Diverse Populations Of Women, Shu Jiang, Debbie L Bennett, Peter Kraft, Graham A Colditz

2020-Current year OA Pubs

Conventional prediction models incorporating genetic and clinical factors including breast density underperform in non-European populations. We investigated an artificial intelligence-derived mammogram risk score (MRS), a summary of texture features that captures intrinsic breast-tissue characteristics-the substrate for cancer development. This study leveraged data from two North American screening cohorts totaling >226,000 women, including non-Hispanic white, non-Hispanic Black, East Asian, South Asian, and Indigenous women. MRS distributions showed nonsignificant shifts (and similar SDs) between cohorts and across race and ethnic subgroups. MRS increased with age and was significantly associated with breast cancer risk, with hazard ratios per SD ranging from 2.24 [95% …

Joint Disease And Demographic Factors In Clinical Populations Of Medically Underserved Communities, Blake C. Martin, Juan Lopez-Alvarenga, Michael Sander

School of Medicine Publications

Background: The Rio Grande Valley is a medically underserved, demographically unique population that warrants the exploration of various conditions.

Objectives: We sought to analyze the demographic disparities between the different types of common joint conditions in this community. We hypothesized that osteoarthritis would be the most common joint condition and that the demographics between the various joint conditions would vary depending on age, sex, BMI, and ethnicity.

Methods: This was a retrospective cohort, from January 1, 2018, to September 4, 2024. Patients’ charts were obtained using the ICD-10 diagnosis codes M15-M19 for osteoarthritis, M05-M06 for rheumatoid arthritis, M10 or M1A …

Dual Orexin Receptor Antagonism With Lemborexant Enhances Microglial Clearance Of Β-Amyloid In Mice, Ashish Sharma, Emiko Segawa, Xiaoying Chen, Sohui Park, Shoutang Wang, Riley E Irmen, Nicholas J Constantino, Chanung Wang, Michael F Kanan, Marco Colonna, Shannon L Macauley, Jocelyn Y Cheng, Ken Hatanaka, Margaret Moline, Erik S Musiek

2020-Current year OA Pubs

BACKGROUND: Sleep disturbances elevate brain amyloid-beta (Aβ) levels and represent a modifiable risk factor for Alzheimer's disease (AD). The orexin/hypocretin system regulates sleep-wake behavior and has emerged as a therapeutic target in AD; however, the effects of FDA-approved dual orexin receptor antagonists (DORAs) on amyloid pathology remain unclear. We compared lemborexant, an FDA-approved DORA, to doxepin, an antihistaminergic sleep medication, on amyloid pathology and microglial responses in PSAPP mice.

METHODS: PSAPP mice received lemborexant (10 or 30 mg/kg/day), doxepin (35 mg/kg/day), or vehicle for 6 weeks beginning prior to plaque onset or 4 weeks after established pathology. Sleep was assessed …

Why Theory Matters In Infant And Toddler Practice: Unpacking Pikler, Gerber, Gesell, Piaget, & Vygotsky, Derrick Toups

Spark! Innovations in Early Childhood Education: A Research-to-Practice Journal for Educators

This article is intended to help infant and toddler educators deepen the why behind the what and how of their daily interactions by unpacking and connecting the seminal early childhood theories of Pikler, Gerber, Gesell, Piaget, and Vygotsky, what they look like in the classroom, and why they benefit children.

Yoga And Young Children, Jayapriya Ranganathan, Cynthia F Dicarlo

Spark! Innovations in Early Childhood Education: A Research-to-Practice Journal for Educators

Abstract:

This article examines the role of yoga as an effective pedagogical tool to support social-emotional learning (SEL) and physical development in early childhood education settings. Grounded in current understandings of mindfulness and executive functioning, the integration of yoga practices—such as breathing exercises, meditation, and developmentally appropriate postures—can promote self-regulation, attention, and emotional resilience in young children. Drawing on classroom-based observations from a toddler program, the article outlines practical strategies for incorporating yoga into daily routines, emphasizing accessibility, consistency, and engagement through imaginative play and storytelling. The findings suggest that regular yoga practice fosters a calm, focused learning environment and …

Implementing Preoperative Anxiety Screening To Enhance Patient-Centered Care: A Quality Improvement Initiative, Adam Chaban, Abigail Limary, Amir Ghafarian, Joyce Li, George Mckelvey, Wael Saasouh

Medical Student Research Symposium

Background: Preoperative anxiety affects 40–80% of surgical patients and is associated with poorer perioperative experiences. Despite evidence linking preoperative anxiety to increase postoperative pain, sleep disturbances, morbidity and delayed recovery, structured anxiety assessment is not routinely integrated into outpatient pre-anesthesia workflows. The Amsterdam Preoperative Anxiety and Information Scale (APAIS) is a validated tool that quantifies patient anxiety and information needs. This quality improvement (QI) project aims to implement APAIS screening in a Pre-Anesthesia Testing (PAT) clinic and evaluate its feasibility, workflow integration, and acceptability.

Methods: This QI initiative will be conducted in adult elective surgery patients at the Detroit Medical …

A Decade Analysis At An Academic Hospital Center Of The Transjugular Intrahepatic Portosystemic Shunt (Tips) Procedure With Intracardiac-Echocardiography (Ice) Guidance., Anointing Onuoha, Sonja Klumpp, Priya Gupta, Riley Draper, Gauthier Dongmo, Peter J. Massa

Medical Student Research Symposium

Title: A decade analysis at an academic hospital center of the Transjugular Intrahepatic Portosystemic Shunt (TIPS) procedure with Intracardiac-echocardiography (ICE) guidance.

Authors- Anointing Onuoha, Sonja Klumpp, Priya Gupta MD, Riley Draper MD, Gauthier Dongmo MD, Peter J. Massa MD. 

Background: The TIPS procedure has been well established since 1989 and has undergone developments with the utilization of Intracardiac-echocardiography (ICE) guidance. The aim of the study is to analyze the utilization of ICE for TIPS procedures.

Methods: A retrospective chart review was conducted, analyzing all TIPS procedures completed at Henry Ford Hospital from January 2010 to January 2024. TIPS procedures were …

Development And Assessment Of A Low-Fidelity Aortic Cross-Clamping Simulation Model, Abdul Naser Zamzami, Omer Abdullah, Trisha Ray, Lauren Malinzak

Medical Student Research Symposium

Title: Development and Assessment of a Low-Fidelity Aortic Cross-Clamping Simulation Model

Authors: Abdulnaser Zamzami(1), BS; Omer Abdullah(1), BS; Trisha Ray(1), BS; Lauren Malinzak(2), MD

Wayne State School of Medicine(1)

Division of Transplant Surgery, Henry Ford Hospital, Detroit, Michigan(2)

Background: Aortic cross-clamping is a high-stakes, technically challenging procedure typically reserved for highly-trained staff, which often excludes resident experience, leaving a crucial training gap for emergency situations. To address this, a mini-curriculum and 3-D hands-on simulation model for supra-celiac and infra-renal clamping were developed.

Methods: Participants, including medical students and up to fourth-year residents, completed pre- and post-surveys as well as hands-on …

Radiomics Analysis Of Deltoid Muscle On Preoperative Shoulder Imaging For Reverse Total Shoulder Arthroplasty, Henry Lee Bs, Christina Hills Bs, Connor Sakis, Humza Bhatti Bs, Arya Sharma, Perra Razoky Md, Prateek Chintalapati Md, Lisa Doan Bs, Adam Alessi Phd, Jared Mahylis Md, Stephanie Muh Md, Chad Klochko Md

Medical Student Research Symposium

Title: Radiomics Analysis of Deltoid Muscle on Preoperative Shoulder Imaging for Reverse Total Shoulder Arthroplasty

Authors: Henry J. Lee BS, Christina Hill BS, Connor Sakis BS, Humza Bhatti BS, Arya Sharma, Perra Razoky MD, Prateek Chintalapati MD, Lisa Doan BS, Adam Alessio PhD, Jared Mahylis MD, Stephanie Muh MD, Chad Klochko MD

Background: Studies have shown that increased preoperative deltoid volume is associated with improved postoperative outcomes in reverse total shoulder arthroplasty (rTSA). Radiomics is a field which uses mathematics and machine learning for image analysis. It shows promise as a tool for characterizing the deltoid preoperatively. This study …

Ghastly Growths And Bone Chilling Cases Pediatric Tumor Diagnosis Demystified, Alexander Aly Restum, Arif Musa

Medical Student Research Symposium

Background:

Pediatric skeletal tumors range from benign to malignant and require multimodal imaging for accurate diagnosis. Recognizing key features enables early detection, guides management, identifies underlying syndromes, and improves outcomes. This presentation provides an educational overview of pediatric tumor evaluation.

Methods:
We conducted a focused review of peer-reviewed literature and representative pediatric imaging studies to outline the radiologic characteristics of common benign and malignant bone tumors in children. Core imaging patterns, diagnostic challenges, and modality-specific advantages were synthesized to create a practical interpretive framework for radiologists.

Results:
The reviewed literature and imaging demonstrated consistent defining features across pediatric bone tumors. …

Enhancing Medical Student Readiness To Provide Care For Youth Involved In The Juvenile Justice System, Tara Rahmani, Noah Kos, Kristen Bartow, Sospeter Machani, Jonathan Hakim, Elyse Vanderwoude, Anastasia Sahu, Abigail Schuch, Jennifer Mendez Ph.D, Laura Benjamins Md,Mph, Faap, Aahivms, Anupama Devara, Adeel Khan D.O.

Medical Student Research Symposium

Title

Enhancing Medical Student Readiness to Provide Care for Youth Involved in the Juvenile Justice System

Authors

Tara Rahmani, Noah Kos, Kristen Bartow, Sospeter Machani, Jonathan Hakim, Elyse VanderWoude, Anastasia Sahu, Abigail Schuch, Jennifer Mendez, Ph.D, Laura Benjamins, MD, MPH, Anupama, Devara, MD, Adeel Khan, DO

Background

Youth involved in the juvenile justice system face profound health inequities with higher rates of mental health needs, substance use, and trauma. Despite this, medical students rarely receive preparation to work in correctional health settings. Prior research has shown that youth in detention often exhibit behaviors shaped by past trauma and neglect, which …

Hot Spots: Zonal Cutaneous Functional Unit Analysis Of High-Risk Regions In Pediatric Shoulder/Hip Scald Burns, Christian Hudson-Bradford Md, Alexander J. Kallabat Bs, Candace R. Marquette Ms, Elika Ridelman Phd, Beth Angst Otr/L, Sarah Hackert Dpt, Pt, Justin Klein Md, Christina Shanti Md

Medical Student Research Symposium

Hot Spots: Zonal Cutaneous Functional Unit Analysis of High-Risk Regions in Pediatric Shoulder/Hip Scald Burns

Authors - Christian Hudson-Bradford, MD, Alexander J. Kallabat, BS, Candace R. Marquette, MS, Elika Ridelman, PhD, Beth Angst, OTR/L, Sarah Hackert, DPT, PT, Justin Klein, MD, and Christina Shanti, MD

Introduction

Pediatric scald burns present significant healing challenges. This study utilizes a novel zonal classification of cutaneous functional units (CFUs) of the shoulder and hip to identify anatomical risk factors and patient characteristics associated with poor outcomes, specifically delayed healing (>14 days) and the need for scar management (SM).

Methods

A retrospective review …

The Prevalence And Effects Of Gestational Maternal Allergy: A Narrative Review, Alice Werynski Bs, Kang Chen Phd

Medical Student Research Symposium

Title:

The Prevalence and Effects of Gestational Maternal Allergy: A Narrative Review

Authors:

Alice Werynski B.S, Kang Chen Ph.D

Background:

Maternal allergies are a prevalent yet overlooked category of gestational disease. Pregnancy is characterized by a Th2 dominant immunological environment, and because many allergic diseases also rely on Th2 cytokines and IgE-mediated pathways, allergy during pregnancy may impact symptoms and influence maternal and fetal outcomes.

Methods:

This narrative review summarizes and compares literature on the prevalence of allergic conditions in pregnancy, their immunologic mechanisms, and their effects on maternal health, fetal development, and treatment safety. The search was conducted through …

Recurrent Laryngeal Nerve Variations And Strategies For Injury Prevention: A Systematic Review, Hana Abdelmeguid, Bamdad Tayyari, Yuvedha Senthil Velan, Michael J. Montalbano Md

Medical Student Research Symposium

Objective

Anatomical variations in the recurrent laryngeal nerve (RLN), namely extra-laryngeal terminal bifurcation and non-recurrent inferior laryngeal nerve, are known risk factors for RLN injury during surgery and represent a considerable jeopardy for iatrogenic damage like vocal cord paralysis. This systematic review aims to identify strategies for protecting RLN during thyroid surgery from nerve damage.

Methods

A search was conducted using EMBASE, MEDLINE, and PUBMED for articles published till February 2023 while strictly adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Subject headings and keywords related to anatomical variations, recurrent laryngeal nerve, and surgical prevention …

Evaluating Normothermic Machine Perfusion For Dcd Liver Transplants: Outcomes, Costs, And Value Implications, Meet S. Patel, Alisha Williams, Kyrillos Ayoub, Noor Kamaladin, Charles S. Day

Medical Student Research Symposium

Background: As liver transplantation expands to include marginal donor organs, technologies such as the TransMedics Organ Care System (OCS) offer the potential to improve graft viability and clinical outcomes. However, limited institution-level evidence exists evaluating the cost-outcomes balance of OCS use in Donation-After-Circulatory-Death (DCD) liver transplantation. This study assesses the clinical, operational, and economic value of OCS implementation within a high-volume transplant center.

Methods: A retrospective cohort analysis was conducted of all DCD liver transplants performed at Henry Ford Hospital from January 2021 to April 2024. Outcomes were compared between traditional cold storage (2021; n=23) and OCS perfusion (2023–2024; n=82). …

From Learners To Leaders: A Peer-Led Simulation Program For Anesthesia Procedural Skills Training In Medical Students, Noah S. Kos, Ryan Beyers, Chloe Sutlick, Benjamin Sun, Tochi Mbagwu, Dr. John D. Mitchell Md

Medical Student Research Symposium

Title: From Learners to Leaders: A Peer-Led Simulation Program for Anesthesia Procedural Skills Training in Medical Students

Authors: Noah Kos, Ryan Beyers, Chloe Sutlick, Benjamin Sun, Tochi Mbagwu, John D. Mitchell, M.D.

Background: Procedural skill competency is vital in medical education, but limited faculty availability poses challenges. We implemented a peer-led simulation program teaching peripheral IV insertion (PIV) and endotracheal intubation, with a focus on student leadership.

Methods: Sixteen peer educators, trained by attendings, conducted monthly workshops from July-October 2025. Students practiced at PIV and intubation stations, assessed via validated rubrics (17 items for PIV, 21 for intubation; 5-point scale). …

Vaccine Communication Through A Global And Local Health Lens, Ivan Kyagaba, Sydni B. Rosenfeld, Shridula Kotakondla, Sarah M. Okeke, Maria F. Pacheco Martinez, Muhammed Zahriyeh, Danielle J. Santoyo, Atta Illahi, Jennifer Mendez, Anupama Devara, Michal T. Ruprecht

Medical Student Research Symposium

Background:

Public trust in vaccines has plummeted. Physicians serve as trusted voices in their communities, so they should be trained to communicate vaccine science effectively. Tailored communication training can help medical students develop adaptable skills for diverse clinical situations. Vaccine inaccessibility in conflict-affected regions differs from vaccine hesitancy in the Global North. This study examines the impact of medical communication education on medical students’ understanding of immunization challenges in conflict zones and their readiness to communicate confidently with patients domestically.

Methods:

A medical communication curriculum was modeled on the impact of missed vaccinations in underserved communities. The curriculum included one …

Health Practices And Use Of Traditional Medicine Among Asian Indian Immigrants In The United States: A Pilot Study, Parita Patel, Anil N.F. Aranha

Medical Student Research Symposium

Title: Health Practices and Use of Traditional Medicine Among Asian Indian Immigrants in the United States: A Pilot Study

Authors

Parita Patel, MPH¹; Anil N.F. Aranha, PhD^1,2

Medical Education¹, Internal Medicine², Wayne State University School of Medicine, Detroit, Michigan

Abstract

Background and Purpose: Traditional and alternative medicine (TAM), including Ayurveda, Homeopathy, Naturopathy, and home remedies, remains widely used among Asian Indian (AI) immigrants in the United States alongside Western medicine. Cultural familiarity, family influence, and perceived safety shape these practices. This pilot study examined TAM prevalence, patterns, and perceptions among AI immigrants and …

Inter-Class Mentorship Improvements At Wayne Directed By Student Senate, Trevor P. Buck, David Abdelnour, Leah Abdallah, Daniel Molnar, Jason Booza

Medical Student Research Symposium

Background: Incoming medical students at Wayne State SOM often face challenges adapting to the expectations and pace of medical school. To support this transition, the Class of 2028’s Student Senate created M101: Survival Guide, a comprehensive student-authored resource for the incoming Class of 2029.

Objective: This student-driven project aimed to provide a clear and consolidated resource to improve preparedness, reduce early academic stress, and foster smoother integration into medical school and extracurriculars.

Methods: The guide was developed through collaborative input from first-year students, incorporating personal experiences from the full M1 curriculum. Content was organized into sections covering themes such as …

Integrating Consumer-Grade Wearable Data Into Orthopedic Risk Stratification For Amateur Athletes: A Perspective On An Untapped Clinical Tool, Youssef Salama, William Gadbois, Kevin Reck, Scott Yaekle

Medical Student Research Symposium

Background:

Consumer-grade wearables have rapidly expanded beyond fitness tracking, providing continuous physiologic and biomechanical data. Metrics such as heart rate variability (HRV), sleep efficiency, and training load have been validated as markers of both recovery and overtraining. However, orthopedic care has not yet translated these data into clinical use. Given the rising burden of overuse injuries in recreational athletes, wearable-derived information may offer a practical opportunity for early detection and prevention within outpatient settings.

Methods:

A narrative perspective review of literature from 2010–2025 was performed using PubMed. Studies addressing wearable device validity, physiologic correlates of musculoskeletal injury, and training-load modeling …

Comparing Injury Incidence Between Major League Soccer And The English Premier League During The 2024/2025 Season: A Retrospective Cohort Study, William Gadbois, Youssef Salama, Kevin Reck, Scott Mohamed El-Sayed Yaekle

Medical Student Research Symposium

Background

Major League Soccer (MLS) and the English Premier League (EPL) differ substantially in geographic footprint, travel requirements, competition structure, and scheduling. These structural differences may influence player injury risk, yet no study has directly compared injury incidence between the two leagues within the same competitive season. In 2024, MLS introduced a centralized, standardized injury-reporting system that improved transparency and created a unique opportunity for direct comparison with the EPL.

Methods

This retrospective cohort study will analyze all reported time-loss injuries during the 2024 MLS and 2024–25 EPL seasons. Injury data will be collected from publicly available league reports, club …

Characterizing Stiffness Dynamics Of Normal And Malignant Breast Spheroids Using Brillouin Microscopy, Razanne Rafat Zaghloul, Karlin Hilai, Chenjun Shi, Jitao Zhang

Medical Student Research Symposium

Background: Breast cancer progression and metastasis are closely linked to alterations in the mechanical properties of tumor cells and their microenvironment. Softer, more deformable cells are often associated with higher metastatic potential. While atomic force microscopy (AFM) is the current gold standard for mechanical characterization, it is limited to surface measurements and can damage 3D cultures. It remains unclear how the mechanical properties evolve over time in normal versus malignant spheroids. This study utilizes Brillouin light-scattering microscopy, a non-contact and label-free optical technique, to assess stiffness changes in normal and malignant breast epithelial spheroids over time. Understanding these mechanical signatures …

Environmental Mercury Alters Immune Pathways Linked To Autoimmune Risk In Mice Mirroring Humans, Maurgan Lee, Paul Stemmer, Randall Gill, Allen Rosenspire, Anil Aranha, Heather Gibson

Medical Student Research Symposium

Background and Purpose: Mercury is a pervasive environmental contaminant, and human epidemiologic studies have linked chronic low-level exposure to increased autoimmune disease-risk. Dysregulated lymphocyte activation and impaired signaling tolerance are central mechanisms in human autoimmunity. Protein phosphorylation governs lymphocyte differentiation and function, alterations in phosphoproteomic networks may represent a signature of immune disruption. This study evaluates how low dose mercury exposure modifies B and T cell abundance and intracellular signaling patterns in BALB/c and Diversity Outbred (DO) mice.

Methods: BALB/c and DO mice were exposed to low dose HgCl2 in their water for two weeks or provided standard water controls. …

Age-Dependent Physiologic Differences And Predicted Survival In Pediatric Trauma Patients, Christian Hudson-Bradford Md, Laura Elizabeth Sansoterra, Elika Ridelman Phd, Samantha Carranza, Megan Zacarias, Christina Shanti Md

Medical Student Research Symposium

Background:
Pediatric trauma patients exhibit outcomes not fully captured by adult-derived prediction models. This study examined clinical measures associated with predicted survival in this population.

Methods:
A retrospective review was conducted at a level one pediatric trauma center for patients ≤12 years old admitted between July 2015 and October 2024 with major trauma (Injury Severity Score (ISS) >15). A total of 406 eligible cases were categorized by Trauma and Injury Severity Score (TRISS) survival probability as preventable (>0.50), possibly preventable (0.25–0.50), or non-preventable (< 0.25). Demographic, physiologic, and management variables were compared using Kruskal–Wallis and chi-square tests with Bonferroni correction.

Results:
Most patients were classified as preventable (83%), followed by possibly preventable (9.8%) and non-preventable …

Comparative Effectiveness Of Liposomal Bupivacaine And Regional Nerve Blocks For Analgesia After Total Knee Arthroplasty, Ahmed Makled, Amir Ghafarian, Jawad Saad, Muhammed Zahriyeh, Muaaz Wajahath, Khaled Saleh

Medical Student Research Symposium

Title: Comparative Effectiveness of Liposomal Bupivacaine and Regional Nerve Blocks for Analgesia After Total Knee Arthroplasty

Introduction: Liposomal bupivacaine (Exparel) has been adopted in total knee arthroplasty (TKA) as a long-acting local anesthetic. However, its comparative effectiveness against standard regional anesthesia techniques, such as femoral or adductor canal block, remains insufficiently defined. This study evaluates postoperative analgesic utilization following TKA among patients receiving Exparel, regional blocks, or no regional intervention, using matched cohorts from a large national dataset.

Methods: Patients who underwent primary TKA between January 1, 2005 and January 1, 2025 were retrospectively identified from a multi-institutional electronic medical …

Real-World Clinical Outcomes Of Robotic-Assisted Total Knee Arthroplasty: A Propensity-Matched Comparative Study, Hassan Yassine, Amir Ghafarian, Jawad Saad, Abdel Kareem Hilo, Muaaz Wajahath, Khaled Saleh

Medical Student Research Symposium

Background:

Robotic-assisted total knee arthroplasty (RA-TKA) is increasingly utilized to improve component alignment and soft-tissue balance, yet its impact on clinically meaningful outcomes in large real-world populations remains uncertain. Although prior studies demonstrate improved radiographic accuracy, whether robotic assistance reduces postoperative complications, opioid utilization, or midterm mechanical failure has not been established at scale.

Methods:

We conducted a retrospective, propensity-matched cohort study using the TriNetX US Collaborative Network to identify adults undergoing primary TKA from 2018–2023. Robotic-assisted procedures were defined by CPT 27447 with concurrent robotic navigation codes. Propensity score matching (1:1) was performed to balance demographics and comorbidities, yielding …

Malnutrition At The Time Of Surgery Predicts Increased Morbidity After Distal Femur Fracture Fixation: A Propensity-Matched Analysis, Jawad Saad, Amir Ghafarian, Tyler Forbes, Muaaz Wajath, Noor Saad, Khaled Saleh

Medical Student Research Symposium

Abstract

Background: Distal femur fractures (DFF) are serious injuries most often affecting older adults with multiple medical comorbidities. Malnutrition is known to worsen outcomes in elective orthopedic surgery, but its impact in urgent DFF fixation, where optimization time is limited, remains unclear. This study evaluated whether preoperative malnutrition predicts 90-day morbidity after DFF fixation and whether implant choice influences risk among malnourished patients.

Methods: Adults undergoing operative DFF fixation from 2005–2025 were identified using the TriNetX U.S. Collaborative Network. Malnutrition was defined as serum albumin ≤3.5 g/dL or leukocyte count ≤1.5×10³/µL within one year preoperatively. After 1:1 propensity matching for …