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Articles 2611 - 2640 of 14999
Full-Text Articles in Medicine and Health Sciences
Respectful Maternity Care: A Narrative Review Of Current Evidence And Clinical Implications, Hadeel Rasheed Seger, Nada Abd Ali Mohammed, Khalid Alyodawi
Respectful Maternity Care: A Narrative Review Of Current Evidence And Clinical Implications, Hadeel Rasheed Seger, Nada Abd Ali Mohammed, Khalid Alyodawi
Preventia: The Indonesian Journal of Public Health
Respectful Maternity Care (RMC) is key to improving quality maternity care and has also been recognized as a foundational approach to quality maternity services. The framework has been developed around respect and promotion of dignified care, confidentiality and privacy, and autonomy of a woman, along with her right to freedom from neglect, discrimination, physical and verbal abuse, during pregnancy and childbirth. Despite worldwide acknowledgment and promotion of RMC, disrespect and abuse during childbirth have been observed among women in maternity settings, especially in low- and middle-income countries. This narrative review summarizes the current evidence and clinical implications of RMC. The …
Kmt2d As An Epigenetic Target In Cervical Cancer: A Literature Review On Polyclonal Antibody Therapeutics And Translational Prospects, Farsya Hidayah Septiananda, Taurisma Aulia Nanda Wibisono, Rajendra Aulya Gilardino, Andreas Budi Wijaya
Kmt2d As An Epigenetic Target In Cervical Cancer: A Literature Review On Polyclonal Antibody Therapeutics And Translational Prospects, Farsya Hidayah Septiananda, Taurisma Aulia Nanda Wibisono, Rajendra Aulya Gilardino, Andreas Budi Wijaya
Preventia: The Indonesian Journal of Public Health
Cervical cancer remains a significant global health burden, particularly in regions with limited access to advanced therapeutics. Beyond viral oncogenesis, accumulating evidence highlights the crucial role of epigenetic dysregulation, particularly KMT2D, in tumor initiation and progression. This literature review aimed to critically synthesize current evidence regarding the biological role of KMT2D in cervical cancer and to explore the opportunities and limitations of antibody-based approaches for future epigenetic intervention. A structured narrative literature review was conducted using PubMed, Scopus, and Web of Science to identify relevant studies published between January 2020 and May 2025. Literature selection was guided by a modified …
Sex-Based Differences In Clinical Outcomes Among Cardiogenic Shock Patients Treated With Mechanical Circulatory Support, Emmanuel Olumuyide, Ju Young Bae, Rongras Damrongwatanasuk, Ezaz Rahman, Barbara Malaga-Espinoza, Jiun-Ruey Hu, S. Elissa Altin
Sex-Based Differences In Clinical Outcomes Among Cardiogenic Shock Patients Treated With Mechanical Circulatory Support, Emmanuel Olumuyide, Ju Young Bae, Rongras Damrongwatanasuk, Ezaz Rahman, Barbara Malaga-Espinoza, Jiun-Ruey Hu, S. Elissa Altin
School of Medicine Publications
Despite advances in therapies, cardiogenic shock (CS) remains associated with high mortality rates, often necessitating mechanical circulatory support (MCS) to preserve end-organ perfusion. Despite increasing rates of MCS utilization, less is known about sex-related differences in clinical outcomes to guide practice. Additionally, standardized management protocols for CS patients requiring MCS that account for sex differences are lacking. In this study, we evaluate sex-specific outcomes in CS patients requiring MCS, examine patterns of MCS utilization by sex, and further stratify clinical outcomes by sex across the overall CS cohort, including the acute myocardial infarction-related CS (AMI-CS), acute heart failure-related CS (AHF-CS), …
The Effect Of Self-Hypnosis On Self-Efficacy, Anxiety, And Depression In Mothers Of Children With Chronic Kidney Disease, Rohmaningtyas Hidayah Setyaningrum, Mohammad Fanani, I Gusti Bagus Indro Nugroho, Debree Septiawan, Siti Wahyuni, Damar Upahita
The Effect Of Self-Hypnosis On Self-Efficacy, Anxiety, And Depression In Mothers Of Children With Chronic Kidney Disease, Rohmaningtyas Hidayah Setyaningrum, Mohammad Fanani, I Gusti Bagus Indro Nugroho, Debree Septiawan, Siti Wahyuni, Damar Upahita
Folia Medica Indonesiana
More than half of caregivers of children with chronic kidney disease (CKD) report experiencing moderate depression (53.3%), while 30% and 16.7% report mild and severe depression, respectively. As primary caregivers, mothers require strong self-efficacy to manage psychological burden associated with caring for children with CKD. Self-hypnosis may enhance self-efficacy and alleviate anxiety and depression in this population. The aim of this study was to evaluate the effects of self-hypnosis in improving self-efficacy and reducing anxiety and depression in mothers of children with CKD. A randomized controlled trial was conducted at Dr. Moewardi Hospital, Surakarta, Indonesia. Thirty-two mothers were randomly assigned …
The Effect Of Plyometric Training On Leg Muscle Explosive Power In Adolescent Amateur Volleyball Players, Dany Fajar Muhlasin, Fendy Nugroho, Jasmine Kartiko Pertiwi
The Effect Of Plyometric Training On Leg Muscle Explosive Power In Adolescent Amateur Volleyball Players, Dany Fajar Muhlasin, Fendy Nugroho, Jasmine Kartiko Pertiwi
Jurnal Fisioterapi Terapan Indonesia
Background: Leg muscle explosive power is a crucial physical component in volleyball, particularly in supporting the execution of smashes and blocks. The ability to generate force rapidly and explosively plays a key role in determining an athlete’s jumping performance. One training method proven effective in enhancing leg muscle explosive power is plyometric exercise. Several recent studies have shown that plyometric training can significantly improve vertical jump performance in adolescent athletes. However, there is still limited research specifically examining the effect of plyometric exercise on jumping explosive power in amateur players aged 14–18 years, indicating a research gap that warrants further …
Pengaruh Rehabilitasi Berbantuan Robot Terhadap Pemulihan Fungsional Setelah Total Hip Arthroplasty: Literature Review, Dian Rahayu Wijayanti, Kholida Nabila, Nadzifa Salsabila Haris Putri, Nur Afrina Azra, Septina Olivia, Farid Rahman
Pengaruh Rehabilitasi Berbantuan Robot Terhadap Pemulihan Fungsional Setelah Total Hip Arthroplasty: Literature Review, Dian Rahayu Wijayanti, Kholida Nabila, Nadzifa Salsabila Haris Putri, Nur Afrina Azra, Septina Olivia, Farid Rahman
Jurnal Fisioterapi Terapan Indonesia
Total Hip Arthroplasty (THA) remains a gold standard for restoring joint function in patients with severe hip osteoarthritis, yet achieving optimal functional recovery post-surgery remains a challenge. Robot-assisted rehabilitation (RAR) has emerged as a novel physiotherapy modality offering structured, repetitive, and sensor-driven training that may enhance recovery trajectories. Objective: This literature review aims to identify and synthesise current evidence on the effectiveness of RAR in improving functional outcomes after THA, focusing on gait performance, muscle strength, balance, and quality of life. Methods: A comprehensive search of PubMed, PEDro, ScienceDirect and Google Scholar was conducted for peer-reviewed articles published between 2015 …
Community-Based Exercise Programs Dalam Mengurangi Fear Of Falling Dan Meningkatkan Quality Of Life Pada Lansia: A Systematic Literature Review, Amirah Hasna Rafifah -, Hanif Maulana, Saffanah
Community-Based Exercise Programs Dalam Mengurangi Fear Of Falling Dan Meningkatkan Quality Of Life Pada Lansia: A Systematic Literature Review, Amirah Hasna Rafifah -, Hanif Maulana, Saffanah
Jurnal Fisioterapi Terapan Indonesia
The global increase in the elderly population presents significant challenges in maintaining independence and quality of life among older adults. One of the most common problems experienced by the elderly is fear of falling, which negatively affects physical activity, balance, and psychological well-being. Community-based exercise programs represent an approach that not only improves physical function but also strengthens social interaction and self-confidence among older adults. This study aims to review community-based exercise programs in reducing fear of falling and improving quality of life among the elderly through a Systematic Literature Review (SLR) using the PRISMA 2020 guidelines. The literature …
Analisis Perbedaan Pengaruh Mc Kenzie Exercise Dan Post Isometric Relaxation Terhadap Penurunan Nyeri Leher Non Spesifik Pada Remaja, Nabila Ayu Meilya Putri, Saifudin Zuhri, Sugiono -
Analisis Perbedaan Pengaruh Mc Kenzie Exercise Dan Post Isometric Relaxation Terhadap Penurunan Nyeri Leher Non Spesifik Pada Remaja, Nabila Ayu Meilya Putri, Saifudin Zuhri, Sugiono -
Jurnal Fisioterapi Terapan Indonesia
Background: The use of laptops and computers has become an essential part of daily life, especially among adolescents. However, the habit of maintaining a static posture for prolonged periods while using these devices often leads to excessive strain on the neck and shoulder muscles. To address these problems, interventions such as Mc Kenzie exercise and post isometric relaxation can be applied. Objective: To determine the difference in the effects of Mc Kenzie exercise and post isometric relaxation on reducing nonspecific neck pain in adolescents. Methods: This study employed a two-group pre and post-test design conducted from June to July 2025 …
Role Of Mcp-1 Serum Level Along With Its Genetic Polymorphism In Open-Angle Glaucoma Disease Susceptibility, Ahmed. A. Cashmosh
Role Of Mcp-1 Serum Level Along With Its Genetic Polymorphism In Open-Angle Glaucoma Disease Susceptibility, Ahmed. A. Cashmosh
Al-Qadisiyah Medical Journal
Background: The chronic optic neuropathy known as slowly developing primary open-angle glaucoma (P.O.A.G.) is typified by unique patterns for optic nerve degeneration as well as vision field loss. is the most prevalent kind, a complicated, multidimensional illness with a pathophysiology influenced by both genetic and environmental variables. Objective: This study's objective is to find the relation between polymorphism of the MCP-1 gene with open-angle glaucoma disease susceptibility along with their proposed role in disease pathogenesis. Materials and Methods: Two groups were the subjects of a case-control study: The first group included 40 patients who had previously been diagnosed with glaucoma, …
Endophytic Actinobacteria: Deciphering Therapeutic And Industrial Potential, And Prospects Of Genome Mining In Novel Products Discovery, Yusra Waheed, Rabia Shahdin, Imran Sajid
Endophytic Actinobacteria: Deciphering Therapeutic And Industrial Potential, And Prospects Of Genome Mining In Novel Products Discovery, Yusra Waheed, Rabia Shahdin, Imran Sajid
Journal of Bioresource Management
Endophytic actinobacteria are a diverse group of Gram-positive bacteria with high G+C content, which inhabit plants’ internal tissues, and represent a significant yet underexplored reservoir of bioactive secondary metabolites. In host plants, a remarkable repertoire of metabolites, including broad-spectrum antibiotics, anticancer, antiviral, antifungal, antioxidant, and immunomodulatory compounds, is synthesized by these microbial allies, carrying significant medicinal and agricultural potential. These endophytes, in contrast to their soil relatives, have developed unique biosynthetic gene clusters (BGCs) strongly influenced by plant-associated factors, leading to the production of structurally novel metabolites. In recent years, the advances in genome mining, metagenomics, and metabolomics have accelerated …
A Mathematical Model For Managing Diphtheria Outbreaks In Nigeria Via Vaccination, Enhanced Surveillance, Effective Quarantine, And Social Distancing Measures, Hycienth Ortser Orapine, Nyiutya Cephas Ine, Dekera Jacob Washachi, Ali Audu Baidu, Lubem Matthew Kwaghkor
A Mathematical Model For Managing Diphtheria Outbreaks In Nigeria Via Vaccination, Enhanced Surveillance, Effective Quarantine, And Social Distancing Measures, Hycienth Ortser Orapine, Nyiutya Cephas Ine, Dekera Jacob Washachi, Ali Audu Baidu, Lubem Matthew Kwaghkor
Mathematical Modelling and Numerical Simulation with Applications
Diphtheria is a highly infectious respiratory and skin disease that poses a significant threat to global public health. In Nigeria, children and adults with low immunity remain at high risk due to recurring annual outbreaks in the last decade, with a death rate of as high as 68.8\%. This paper presents a deterministic compartmental model to evaluate the effectiveness of interventions implemented by the Nigerian government. The model's mathematical and epidemiological validity is established through proofs of non-negativity and boundedness. The basic reproduction number ($R_0$) is derived, and stability analysis confirms that the diphtheria-free equilibrium is locally and globally asymptotically …
Stochastic Analysis Of Epidemic Size And Peak Infection In An Svir Model With Imperfect Vaccine And External Source Of Infection, María Gamboa Pérez
Stochastic Analysis Of Epidemic Size And Peak Infection In An Svir Model With Imperfect Vaccine And External Source Of Infection, María Gamboa Pérez
Mathematical Modelling and Numerical Simulation with Applications
The dynamics of an infectious disease outbreak are studied under a stochastic framework in a closed population where individuals are homogeneously mixed. A vaccination program is implemented in the community prior to the start of the epidemic. The administered vaccine is imperfect, meaning that vaccinated individuals may still become infected upon contact with infected individuals. The mathematical Susceptible-Vaccinated-Infected-Recovered (SVIR) model describing the evolution of the epidemic is formulated as an absorbing, continuous-time, three-dimensional Markov chain with compartments for vaccinated, susceptible, infected and recovered individuals. The aim of this study is to characterize two fundamental epidemiological quantities: the maximum number of …
The Prevalence Of Oral Diseases In Heredity Bleeding Disorders In Iraq, Warkaa M. Al-Wattar
The Prevalence Of Oral Diseases In Heredity Bleeding Disorders In Iraq, Warkaa M. Al-Wattar
Al-Esraa University College Journal for Medical Sciences
Aim: To investigate the effect of bleeding disorder on oral condition in Iraqi patients. Patient and methods: 153 patients were included in this study attending dental unit in Iraqi center of hematology. They were diagnosed and treated for ordinary oral diseases like dental caries and periodontal diseases mainly. While treatment vary from only diagnosis and checkup to more complicated surgical extraction. The patients data include sex, blood group, cheife complain and type of treatment. Results: The main chief complain was dental caries and less periodontal diseases while main treatment management was only checkup. The blood group O was the most …
Association Between Body Mass Index, Vitamin D3 And Lipid Profile In Type 2 Diabetes Mellitus, Eman Ali Hussein, Hulia Kanan Mohammed, Zainab Abduljabbar Ridha Al-Ali, Qater Alnada Jassim Mohammed, Alaa Al-Noori, Tarik Muhammad Ali, Noor Thair Tahir
Association Between Body Mass Index, Vitamin D3 And Lipid Profile In Type 2 Diabetes Mellitus, Eman Ali Hussein, Hulia Kanan Mohammed, Zainab Abduljabbar Ridha Al-Ali, Qater Alnada Jassim Mohammed, Alaa Al-Noori, Tarik Muhammad Ali, Noor Thair Tahir
Al-Esraa University College Journal for Medical Sciences
Dyslipidemia and vitamin D Deficiency are one of the most common disorders among type 2 DM patients, this study was conducted to investigate in the relationship between lipid profile and vitamin D status and body mass index (BMI) Among DM patients in Baghdad province / Iraq. study was madeon 120 subjects (diabetic as well non diabetic). The fasting blood glucose (FBG) levels, glycated HbA1c), lipid profile including total cholesterol, triglycerides, LDL, HDL andVLDL levels and serum vitamin D level were analyzed. Current study observied that the values for FBG, HbA1c, insulin, HOMOIR, TC, TG, HDL, LDL, VLDL, and Vitamin D, …
Effect Of High Protein Diets On Kidney Health Among Athletes And Bodybuilders With Normal Kidney Function, Mustafa Mehdi Alqazzaz, Sajad Abdullah Jleep, Nouran Hussein Mutlaq, Ali Jabbar Jassem
Effect Of High Protein Diets On Kidney Health Among Athletes And Bodybuilders With Normal Kidney Function, Mustafa Mehdi Alqazzaz, Sajad Abdullah Jleep, Nouran Hussein Mutlaq, Ali Jabbar Jassem
Al-Esraa University College Journal for Medical Sciences
This study emphasizes the effect of high-protein diets(HPD) on kidney function, focusing on key biomarkers (Albumin, Urea, Creatinine & GFR). A HPD is defined as a protein consumption >1.5g/kg per day. Results indicated variations in certain biomarkers among the participants (healthy athletes & bodybuilders with normal kidney function) suggesting potential changes in renal workload. Many studies in resistance-trained athletes focusing at HPD, concluded that there are no harmful effects of HPD on renal health. While no immediate kidney damage was observed, we suggest further investigation into the long -term implications of HPD, particularly for individuals with specific health conditions.
Atracurium And Rocuronium On Pain Score During Intravenous Injection, Suha Adel Qasim Al-Ani
Atracurium And Rocuronium On Pain Score During Intravenous Injection, Suha Adel Qasim Al-Ani
Al-Esraa University College Journal for Medical Sciences
Background: The non-depolarizing muscle relaxant (NDMR) is generally used in anesthesia for facilitation of intubations and muscle relaxations. Nevertheless, pains during injections remain as significant concerns. Aim of the Study: The aim of the study was to compare levels of pain scores related to various types of NDMR (Atracurium and Rocuronium) during injections. Patients and Methods: This study was applied on (60) patients whose ages ranged between (18–65) years and underwent different surgical operations. Patients are categorized into two groups: (31) patients receiving IV Atracurium and (29) receiving Esmeron (Rocuronium) in different doses. Following IV injection of the drug, immediate …
Epidemiology, Classification, Risk Factors, Pathophysiology And Management Of Diabetes Mellitus: A Review, Mohammed Raad Khalaf, Tariq Muhammed Ali, Entedhar K. Hussain, Alaa Al-Noori
Epidemiology, Classification, Risk Factors, Pathophysiology And Management Of Diabetes Mellitus: A Review, Mohammed Raad Khalaf, Tariq Muhammed Ali, Entedhar K. Hussain, Alaa Al-Noori
Al-Esraa University College Journal for Medical Sciences
Diabetes mellitus is a common metabolic disorder, remains a global health challenge with escalating prevalence rates, necessitating a thorough understanding of its multifaceted aspects for effective management. This review synthesizes current knowledge on the epidemiology, classification, risk factors, pathophysiology, and management strategies of diabetes. The epidemiology highlights the rising global prevalence of DM and its regional variations, emphasizing the socio-economic and demographic factors contributing to this epidemic. The classification provides an in-depth analysis of the evolving classification systems, encompassing Type 1, Type 2, and gestational diabetes. Risk factors associated with the development of diabetes are explored, encompassing genetic predisposition, lifestyle …
The Pivotal Role Of Artificial Intelligence In Optimizing Pharmaceutical Formulation And Delivery, Ali Khidher Abbas, Mustafa M. Noori, Ibtihal Abdulkadhim Dakhil, Mohammed Hussain Al-Mayahy
The Pivotal Role Of Artificial Intelligence In Optimizing Pharmaceutical Formulation And Delivery, Ali Khidher Abbas, Mustafa M. Noori, Ibtihal Abdulkadhim Dakhil, Mohammed Hussain Al-Mayahy
Al-Esraa University College Journal for Medical Sciences
Artificial intelligence (AI) has emerged as a transformative technological paradigm within the pharmaceutical sciences, offering innovative and forward-looking solutions to surmount the inherent limitations associated with conventional drug development, formulation design, and therapeutic delivery systems. Traditional pharmaceutical methodologies frequently entail protracted development timelines, extensive experimental procedures, and substantial financial expenditures, particularly within the domains of formulation optimization and drug delivery design. The integration of AI-driven technologies – encompassing machine learning (ML), deep learning (DL), artificial neural networks (ANNs), and predictive analytics – has considerably accelerated pharmaceutical research by refining decision-making processes, alleviating experimental burden, and enhancing formulation efficiency. The present …
The Pathological Interaction Between Diabetes And Hypertension: Mechanisms And Clinical Complications, Alaa Al-Noori, Ayad Ahmed Al-Taweel, Qater Alnada Jassim Mohammed, Tarik Muhammad Ali, Majeed Mihsin B. Al-Hamdani, Noor Thair Tahir
The Pathological Interaction Between Diabetes And Hypertension: Mechanisms And Clinical Complications, Alaa Al-Noori, Ayad Ahmed Al-Taweel, Qater Alnada Jassim Mohammed, Tarik Muhammad Ali, Majeed Mihsin B. Al-Hamdani, Noor Thair Tahir
Al-Esraa University College Journal for Medical Sciences
Among the most prevalent chronic conditions, diabetes and hypertension frequently coexist in a single patient, aggravating vascular problems and hastening the deterioration of target organs, especially the kidneys. By raising intraglomerular pressure, impairing endothelial function, and triggering oxidative stress and inflammation, hypertension directly increases the chance of developing diabetes sequelae, including diabetic nephropathy. Chronic kidney disease advances more quickly when poorly managed hyperglycemia and hypertension combine to cause a decrease in glomerular filtration rate and an increase in urine albumin excretion. Other consequences like retinopathy, neuropathy, and cardiovascular disease are also encouraged by this pathological occurrence. Reducing the advancement of …
Clinical Significance Of Liver Enzyme Biomarkers In Chronic Statin Users, Muayad Khaleel Ibrahim, Saad Mahmoud Saeed
Clinical Significance Of Liver Enzyme Biomarkers In Chronic Statin Users, Muayad Khaleel Ibrahim, Saad Mahmoud Saeed
Al-Esraa University College Journal for Medical Sciences
It is possible that statins, by their dual capacity to modulate (both stimulate and suppress) immune responses, could play a role in influencing the course of autoimmune diseases. Consequently, our investigation was designed to explore how statins impact both the innate and adaptive branches of the immune system, as well as their effect on the crucial mechanism of self-tolerance. This was achieved through the comprehensive measurement of various antibody profiles, specifically including the detection and quantification of autoantibodies, such as antinuclear antibodies and Creatinine kinase, Aldolase, HMGCR antibody, Albumin and Bilirubin and Alanine transaminase, Aspartate aminotransferase, Our investigation employed a …
Some Pathogenic Agents Isolated From Gento-Urinary Tract Of Females Patients In Baghdad Area, I. M. Al-Saqur, A. N. Al-Thwani, E. M. Abdul Ameer, S. W. Abd-Al-Zhra, M. K. Sahan, H. S. Ferman, A. A. Hassan, H. M. Hassan
Some Pathogenic Agents Isolated From Gento-Urinary Tract Of Females Patients In Baghdad Area, I. M. Al-Saqur, A. N. Al-Thwani, E. M. Abdul Ameer, S. W. Abd-Al-Zhra, M. K. Sahan, H. S. Ferman, A. A. Hassan, H. M. Hassan
Al-Esraa University College Journal for Medical Sciences
The Urinary Tract Infection (UTI) represents a significant global health burden and the pathogens which inhibit the geneto - urinary Tract (GUT) of women cause devastating consume. In this study investigation UGT were carried out through examination of 186 women (183 married and 65 unmarried) who attended Damascus Private Medical Center-Baghdad, through the period from the beginning of January 2023 to the end of August 2023. Detection were conducted according to the standard methods after macroscopically and macroscopically examination of u samples. The results, indicated that 121 (65.05%) were infected and married women had high infection (78.86%) than the unmarried …
Measuring The Concentration Of Heavy Metals In The Serum Of Traffic Police And Their Impact On Heart Disease In The Future, Hanaa Khalil Sacheat
Measuring The Concentration Of Heavy Metals In The Serum Of Traffic Police And Their Impact On Heart Disease In The Future, Hanaa Khalil Sacheat
Al-Esraa University College Journal for Medical Sciences
The spread of heavy metals such as lead, cadmium and nickel is a clear danger that threatens the earth and disrupts the ecological balance. In this research, we evaluated the danger of these metals present in the areas of traffic points for traffic policemen who are present for long periods at traffic points. 25 blood samples were collected from traffic policemen present at traffic points, with information about age, date of joining the job, and smoking, The comparison was made with the same number of samples of people who were in a job inside buildings, The results showed a significant …
Tumor–Immune Dynamics With Memory And Time Delay: A Fractional-Order Model With Ctla-4 Regulation, Mutaz Mohammad, Mohyeedden Sweidan, Alexander Trounev, Fathalla Rihan
Tumor–Immune Dynamics With Memory And Time Delay: A Fractional-Order Model With Ctla-4 Regulation, Mutaz Mohammad, Mohyeedden Sweidan, Alexander Trounev, Fathalla Rihan
Mathematical Modelling and Numerical Simulation with Applications
This study develops a fractional-order tumor-immune interaction model incorporating Caputo memory effects, delayed immune activation, and CTLA-4 checkpoint regulation. The model describes the coupled dynamics of tumor cells, CD4$^{+}$ T cells, IFN-$\gamma$, and CTLA-4, and extends classical integer-order tumor-immune models by accounting for hereditary immune responses and biologically motivated latency effects. Theoretical properties, including positivity, boundedness, equilibrium structure, and fractional-order stability, are examined to establish the biological and mathematical consistency of the model. The delayed fractional system is then investigated computationally by comparing several numerical methods, including finite difference discretization, Daubechies wavelet collocation, Euler wavelet collocation, and a predictor-corrector scheme. …
Crispr/Cas9-Based Genome Editing: Understanding Differences In Dna Repair Pathways, Profiles, And Outcomes, Samuel Effah, Shirley Barrera, Nahia Urturi Ortiz, Will Dampier, Michael Nonnemacher, Brian Wigdahl
Crispr/Cas9-Based Genome Editing: Understanding Differences In Dna Repair Pathways, Profiles, And Outcomes, Samuel Effah, Shirley Barrera, Nahia Urturi Ortiz, Will Dampier, Michael Nonnemacher, Brian Wigdahl
Kimmel Cancer Center Faculty Papers
Over a decade of advances in Clustered Regularly Interspersed Short Palindromic Repeats (CRISPR) and CRISPR-associated protein 9 (Cas9)-based technologies have culminated in the first-ever FDA-approved CRISPR/Cas-based therapy. Aside from this approved therapy for sickle cell anemia, several CRISPR/Cas-based therapies are currently under development or testing for a range of chronic diseases, including viral diseases like human immunodeficiency virus type 1 (HIV-1) infection, genetic diseases like familial hypercholesterolemia, and cancer. The success of these therapies hinges on the effective delivery of CRISPR/Cas9 components to target regions, efficient Cas endonuclease editing, repair profiles generated, and their resulting outcomes. Here, we discuss the …
Us Race/Ethnic Disparities In Diabetes Technologies: A Systematic Review And Meta-Analysis Of 950 000 Individuals, Maria L. M. Rego, Maxim Barnett, Maria Helena Siqueira Tavares De Melo, Ana Rivadeneira
Us Race/Ethnic Disparities In Diabetes Technologies: A Systematic Review And Meta-Analysis Of 950 000 Individuals, Maria L. M. Rego, Maxim Barnett, Maria Helena Siqueira Tavares De Melo, Ana Rivadeneira
Einstein Health Papers
PURPOSE: To provide a descriptive summary and to quantitatively examine racial and ethnic disparities in the use of continuous glucose monitoring (CGM) and continuous subcutaneous insulin infusion (CSII) among people living with diabetes in the United States.
RESEARCH DESIGN AND METHODS: We followed the Cochrane and PRISMA guidelines (PROSPERO: CRD420251124678). Search was conducted on PubMed, Embase, and Cochrane up to August 2025. Observational studies were included if they (1) were conducted in the United States, (2) evaluated the use of CGM/CSII across different races/ethnic groups, and (3) reported odds ratios (ORs) for between-group comparisons. Three-level random-effect meta-analyses examined OR in …
Liver Function Tests, Calcium, And Phosphorus Levels In The Graves' Disease Patients, Munaf Faraj Rashid, Haider Abd. Jabbar Alammar, Abbas Mahdi Rahmah
Liver Function Tests, Calcium, And Phosphorus Levels In The Graves' Disease Patients, Munaf Faraj Rashid, Haider Abd. Jabbar Alammar, Abbas Mahdi Rahmah
Al-Qadisiyah Medical Journal
Background: Graves' disease is an autoimmune disorder that affects the thyroid gland, a small butterfly-shaped organ located in the anterior of the neck. In this case, the immune system mistakenly attacks the thyroid, leading to the overproduction of thyroid hormones. The most common result of Graves' disease is an overactive thyroid gland, which produces an excess of thyroid hormones (thyroxine or T4 and triiodothyronine or T3). This can lead to symptoms such as weight loss, rapid heartbeat, anxiety, irritability, heat intolerance, and increased sweating. The thyroid gland may become enlarged, causing a noticeable swelling in the front of the neck. …
Psoriasis Effects On Psychological And Daily Activities In Patients Attending To Outpatient Clinics In Aldiwaniyah Teaching Hospital, Saja Abbas Musa, Hassan Raji Jallab, Akeel Hamid Jabur
Psoriasis Effects On Psychological And Daily Activities In Patients Attending To Outpatient Clinics In Aldiwaniyah Teaching Hospital, Saja Abbas Musa, Hassan Raji Jallab, Akeel Hamid Jabur
Al-Qadisiyah Medical Journal
Background: Psoriasis is a chronic immune-related skin disorder affecting 2–3% globally, linked to heart disease, joint issues, metabolic syndrome, and psychological disorders. It also impacts social life, mental health, and work productivity, with added challenges in Middle Eastern patients due to stigma and limited healthcare access. Aim: To assess the psychological and functional impact of psoriasis on patients attending Al-Diwaniyah Teaching Hospital. It focuses on anxiety, depression, social disengagement, and effects on daily activities like work, exercise, sleep, and hygiene. The study also explores the relationship between disease severity and impairment levels. Material and Methods: The study was conducted at …
Correlation Of Norepinephrine With Some Biochemical Parametric In Patients With Type 2 Diabetes Mellitus, Aqeel Abed Nour Hadi, Ferdous A. Jabir, Muhammad Abd-Alwahab
Correlation Of Norepinephrine With Some Biochemical Parametric In Patients With Type 2 Diabetes Mellitus, Aqeel Abed Nour Hadi, Ferdous A. Jabir, Muhammad Abd-Alwahab
Al-Qadisiyah Medical Journal
Background: Type 2 diabetes is a chronic metabolic disorder characterized by high blood sugar levels (hyperglycemia) resulting from the body's reduced ability to produce or use insulin effectively. Insulin is a hormone that regulates blood sugar levels, and in type 2 diabetes, the body either does not produce enough insulin or becomes resistant to its effects. This causes a buildup of glucose in the bloodstream, which can eventually harm organs and tissues. This study was carried out on patients who attended the Diabetes and Endocrinology Specialist Center of Marjan City for Medical Education in Babil Province; all patients were diagnosed …
Lipase And Tcf7l2 Polymorphism As Indicators Of Pancreatic Dysfunction In Patients With Breast Cancer, Dhay Ihab Al-Jdooa, Ahmed Ghdhban Al-Ziaydi
Lipase And Tcf7l2 Polymorphism As Indicators Of Pancreatic Dysfunction In Patients With Breast Cancer, Dhay Ihab Al-Jdooa, Ahmed Ghdhban Al-Ziaydi
Al-Qadisiyah Medical Journal
Background: Pancreatic dysfunction is widely acknowledged as a critical issue in individuals with breast cancer. These biomarkers like insulin, lipase, and amylase or polymorphisms such as TCF7L2 can be correlated in assessing breast cancer in conjunction with other medicine relations such as pancreatic health. Objective: The aim of this particular study is to assess the role of breast cancer in pancreatic dysfunction by assessing the aforementioned biomarkers and gene polymorphisms. Methods: Following ethical guidelines, a case-control study was conducted involving female patients diagnosed with breast cancer and other breast cancer-free women. Various combined diagnostic tests, including ROC curve analysis and …
Ophthalmic Complications In Thalassemia Patients Using Iron Chelating Therapy, Haider Aswad Layikh, Zainab Yousif Ismael, Dheya Nema Kadhum
Ophthalmic Complications In Thalassemia Patients Using Iron Chelating Therapy, Haider Aswad Layikh, Zainab Yousif Ismael, Dheya Nema Kadhum
Al-Qadisiyah Medical Journal
Background:\ Thalassemia's are a group of genetic diseases which are considered as the most common single gene disorder which are usually treated with repeated blood transfusions that may lead to iron accumulations in the body with multi organ complications. Objectives:\ The objectives of this study was to evaluate the most commonly observed ocular signs and complications of beta-thalassemia major, as well as to determine whether there are any significant ocular side effects of the iron chelators taken by many of these patients for the treatment of their condition. Materials & Methods:\ this cross sectional study evaluated the …