Medicine and Health Sciences Commons^™

Effect Of Traditional And Cluster Set Structures On Bar Path Kinematics During High-Volume Power Clean Training, Tsuyoshi Nagatani, Shayne Vial, Kristina L. Kendall, Paul Comfort, Jiahao Yang, G. Gregory Haff

Research outputs 2022 to 2026

The aim of this study was to examine the effects of traditional (TRAD) and cluster (CLU) set structures on bar path kinematics during a series of high-volume power clean sets, and compare insights gained from discrete versus waveform analysis. Twenty participants completed TRAD or CLU protocols in a randomised, crossover design. Each protocol involved three sets of nine repetitions at 70% of one-repetition maximum. In CLU sets, a 30-second inter-repetition rest was applied. During TRAD sets, peak velocity declined, and significant (p ≤ 0.05) changes were observed in both vertical and horizontal barbell displacement across repetitions, indicating fatigue-related technical alterations. …

An Investigation Of The Motivations And Experiences Of Adults With Communication Disorders Attending A Student-Led Speech Pathology Clinic, Alana Filing

Theses : Honours

Introduction: Student-led clinics (SLCs) are recognised as a valuable initiative for developing student clinical competencies, expanding placement capacity, and delivering targeted health intervention within the community. Despite the recognised benefits of SLCs, there is a notable lack of research investigating adult clients’ motivations for engaging with these services and their experiences of attending SLCs, particularly within speech pathology (SP) contexts.

Objective: This study investigated factors influencing adult clients’ initial engagement with a SP SLC and explored their experience with the service.

Method: A qualitative descriptive design was employed to capture clients’ experiences. Data were collected through semi-structured, face-to-face (F2F) interviews …

The Effects Of Abused Drugs On Ferroptosis Pathways: Potential Therapeutic Targets For Substance Use Disorders, Tamara Bouchard, Brooke Russell, Liam Liyang Guo, Tina Nguyen, Yan Cheng, Yan Y. Sanders, Ming-Lei Guo

Department of Biomedical and Translational Sciences Faculty Publications

Substance use disorders (SUDs) remain major public health concerns worldwide, particularly in developed countries. SUDs are characterized by persistent neuroinflammation and synaptic dysfunction in the brain. Despite decades of extensive investigation, the detailed mechanisms underlying SUDs remain elusive. Ferroptosis is a highly regulated cell death process deeply affected by iron metabolism, lipid peroxidation, reactive oxygen species (ROS) production, and antioxidant systems. It has been implicated in multiple neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and ischemic stroke. Recently, emerging evidence has highlighted the role of ferroptosis in drug-induced pathological changes. Various types of abused …

Metabolic Profiles Distinguish Normal And Malignant Breast Tissues In African American Women, Delisha A. Stewart, Lance Buckley, Wimal W. Pathmasiri, Susan L. Mcritchie, Tammey J. Naab, Robert L. Dewitty, Kelly Bolden, Estelle Cooke-Sampson, Desta A. Beyene, Vikisha T. Fripp, Luisel Ricks-Santi, Robert L. Copeland, Jr., Susan J. Sumner, Yasmine M. Kanaan

Department of Biomedical and Translational Sciences Faculty Publications

Background: Breast cancer (BCa) is the most common malignancy in women where incidence, distribution, clinical outcomes, and mortality rates vary widely among women of different racial and/or ethnic backgrounds.
 
Methods: To explore the metabolome of normal and malignant breast tissues and try to discriminate BCa disease in a cohort of African American women, biospecimens (n=48) were analyzed by untargeted metabolomics using 1H nuclear magnetic resonance (NMR) spectroscopy. Breast specimens were characterized as control or malignant. Control samples were obtained from reduction mammoplasty surgeries, including those with benign fibrocystic changes or non-malignant fibroadenoma, whereas malignant BCa samples encompassed grades I-III and …

Memoryart: Enhancing Llms Via Multi-Memory Models With Adaptive Resonance Theory For Healthcare Agents, Renke Dai, Hebin Hu, Jiahui Zhang, Yilin Kang, Ah-Hwee Tan

Research Collection School Of Computing and Information Systems

Though promising in healthcare consultation applications, large language models (LLMs) face critical limitations in retaining and utilizing long-term memory across multiturn interactions. In particular, existing memory enhancing paradigms are constrained by limited context windows and embedding-based retrieval, often failing to maintain task relevance and still suffering from memory prototype collapse in multi-turn healthcare consultation. To address these challenges, we propose a cognitively-inspired memory framework named MemoryART, which is grounded in Adaptive Resonance Theory (ART)—a cognitive and learning theory of how humans and animals adapt to dynamic environments. MemoryART employs three memory modules—working memory, episodic memory, and semantic memory to support …

Analysis Theories On Artificial Intelligence, Chatgpt, Data Science, And Metaverse: The Case Of Digital Medicine, Yin Yang, Xingyun Liu, Jorge Luis Cuyubamba Dominguez, Yuan Fang, Wen Xie, Bairong Shen, Keng Siau

Research Collection School Of Computing and Information Systems

Healthcare organizations are increasingly adopting digital technologies, with Artificial Intelligence (AI), Data Science, and the metaverse driving significant advancements in smart healthcare. Al facilitates personalized medicine and efficient drug development, while Data Science enables predictive analytics and big data management, enhancing patient outcomes and healthcare quality. The metaverse introduces immersive training and telemedicine platforms, revolutionizing patient engagement and healthcare research. This study conducts' a scoping review of 6,171 articles, analyzing the transformational impact of AI, ChatGPT, Data Science, and the metaverse on healthcare. It highlights the benefits and risks of these technologies, identifies research gaps in their application within the …

Social Support As An Effect Modifier Of The Assocation Between Drug-Use Related Stigma And History Of Substance Use During Pregnancy Among Women Who Use Unprescribed Opioids In New York City: A Cross-Sectional Study, Isabelle C. Lynch

Graduate Studies Theses and Dissertations 2026

Substance use and misuse among women who are pregnant is a growing public health concern in the United States. Overdose deaths are now a leading cause of death among pregnant and postpartum women, and neonatal abstinence syndrome rates have increased to 23 per 1000 births. A barrier addressing substance use among these women is social stigma, which in part is driven by punitive drug policies that criminalize substance use during pregnancy and societal gender roles and norms surrounding women’s substance use. Social support, including emotional, instrumental, and informational support, can serve to mitigate the negative impacts of stigma on health …

Behavioral Economic Factors Implicated In Young Adult Drinking In The Natural Environment: An Ema Study, Tatiana Magri

Graduate Studies Theses and Dissertations 2026

Background: Young adult (YA) alcohol use remains a prominent public health concern. Despite research efforts aimed at mitigating harms related to drinking, rates of alcohol use and adverse outcomes related to use, remain high among YAs. Previous research has identified alcohol demand, craving, and delay discounting as risk factors for problematic drinking among YAs. However, few studies have concurrently examined these constructs using methodologies that maximize ecological and contextual validity. Method: YA individuals (N=104) completed an ecological momentary assessment (EMA) protocol assessing three demand indices (i.e., intensity, Omax, and breakpoint), delay discounting, craving, and alcohol use and problems. Participants received …

Exploring The Role Of Hes4 During Retroviral Infection, Raphael Opoku

Graduate Studies Theses and Dissertations 2026

Human immunodeficiency virus (HIV) infection disrupts immune homeostasis and impairs antiviral defenses, partly by compromising natural killer (NK) cell activity, with simian immunodeficiency virus (SIV) infection in rhesus macaques serving as a valuable model to investigate these mechanisms. This research examines the regulatory role of HES4 and its isoforms in NK cell function during retroviral infection, with particular focus on how Notch signaling–dependent regulation of HES4 shapes NK effector responses. HES4, a downstream effector of the Notch signaling pathway, encodes transcriptional repressors central to immune cell differentiation, yet its contribution to NK cell biology remains poorly understood. Using molecular and …

Investigating The Association Between Polycystic Ovary Syndrome (Pcos) And Idiopathic Intracranial Hypertension (Iih): A Cross-Sectional Analysis, Savannah L. Adams

Graduate Studies Theses and Dissertations 2026

Polycystic ovary syndrome (PCOS) and idiopathic intracranial hypertension (IIH) are chronic conditions that disproportionately affect women of reproductive age and share several metabolic risk factors, including obesity, insulin resistance, and hormonal dysregulation. Despite growing clinical interest in a potential relationship between these conditions, limited research has examined awareness, knowledge, symptom presentation, and barriers to healthcare among young adult populations. The purpose of this study was to investigate awareness, knowledge, perceived healthcare barriers, and potential associations between PCOS and IIH among college-aged individuals. A cross-sectional survey was administered to students aged 18-25 at the University of Central Florida through classroom recruitment …

Do Fair Schedules Matter? Work-Home Conflict And Justice In Emergency Medicine, Maresca J. Brand

Graduate Studies Theses and Dissertations 2026

Emergency physicians work in a high-demand environment requiring irregular, around-the-clock schedules, which can contribute to elevated work-home conflict and burnout. While previous research has focused on objective schedule characteristics such as length of shift or time of day worked, less attention has been given to how emergency physicians perceive the fairness of the scheduling process itself. Drawing on Work-Home Resources Theory and Personal Resource Allocation Theory, this study examines whether perceptions of schedule justice influence work-home conflict via schedule satisfaction. I propose that perceived fairness in schedule creation functions as a contextual resource that shapes whether a schedule is experienced …

Homoplasy Of Maxillary Orthognathism In Derived Homo, Jared Jordan

Graduate Studies Theses and Dissertations 2026

The evolution of the orthognathic condition in the genus Homo represents a monumental transition toward the facial morphology of modern humans from that of earlier hominins, but the phylogenetic positioning of this transformation remains poorly understood. This study investigated temporal trends in maxillary and mandibular prognathism in the genus Homo, and whether maxillary and mandibular shortening in East Asian H. erectus and later East Asian Middle Pleistocene Homo (e.g., Homo longi) represent independent derivations of orthognathic morphology, thereby making orthognathism a homoplasy in the genus Homo. Using a sample of roughly 109 cranial and mandibular specimens spanning …

Establishment Of An In Vitro Dss-Induced Epithelial Injury Model To Investigate Il-6 Signaling And Microbial Metabolite Mediated Barrier Recovery, Srijal Kunwar

Graduate Studies Theses and Dissertations 2026

Dextran sodium sulphate (DSS) is widely used in vivo to induce epithelial injury; however, the molecular effects of DSS on intestinal epithelial cells, that investigate inflammatory and metabolic repair mechanisms remain unclear. Here, we establish an in vitro DSS-induced epithelial damage model using differentiated Caco-2 cell monolayer. Exposure to 2.5%(w/v) DSS for 24 hours resulted in significant upregulation of pore forming protein Claudin-2(2.677-fold) and oxidative marker, NOX-1(1.866-fold), accompanied by increased ROS production confirmed via DHE staining. Increased epithelial permeability was observed by TEER analysis, without significant cytotoxicity. Surprisingly, ELISA analysis revealed significant downregulation of IL-6 (p-value …

Perspectives Of Poetry: Peering Into Poetry And Aphasia, Kristian M. Perez

Graduate Studies Theses and Dissertations 2026

People with aphasia often experience significant barriers to communication, emotional expression, and participation in meaningful life activities following stroke or neurological injury. Although poetry and creative expression have been explored in broader therapeutic contexts, limited research has examined how people with aphasia perceive poetry. The purpose of this qualitative study was to explore the perspectives of people with aphasia regarding definitions of poetry, level of interest in poetry and the factors influencing said interest. Semi-structured interviews were conducted with adults with aphasia recruited through convenience sampling. Participants responded to questions before and after exposure to the poem Trust by Mark …

Investigating The In Vitro Antimicrobial Potential And Comprehensive Computational Studies Of New Schiff Base Derivatives, Abrar Hussain, Shahzaib Akhter, Hammad Nasir, Khurram Shahzad, Muhammad Arfan, Sand Hyun Park

Chemistry & Biochemistry Faculty Publications

Antimicrobial resistance (AMR) is a growing global health threat driven by multidrug-resistant bacteria (Staphylococcus aureus, Pseudomonas aeruginosa), and fungi (Candida albicans, and C. parapsilosis). This study evaluated six novel Schiff base derivatives (HSB-1 to HSB-6) through integrated in vitro antimicrobial activity and comprehensive computational studies. In vitro disk diffusion assay demonstrated the largest zones of inhibition against S. aureus for HSB-6 and HSB-1 (15–17 mm), activity against P. aeruginosa for HSB-5 and HSB-6 (12 mm), and moderate antifungal activity for HSB-4 (8–11 mm). Molecular docking results correlated with the in vitro findings with the binding energy ΔG = −12.3 kcal/mol …

Expanded Scorpionate And Siderophore-Inspired Ligands: From Foundational Designs To Modern Applications, Austin Winfield Medley, Trandon Allen Bender

Chemistry & Biochemistry Faculty Publications

Scorpionate ligands have been advanced significantly through systematic modifications of their apical atoms and heterocyclic arms, expanding their structural diversity and chemical reactivity. Recent biologically inspired variants now enable accurate modeling of complex bioinorganic motifs, such as the Fe₄S₄ clusters of nitrogenase, and support enzyme‐like reactivity under mild aqueous conditions. These developments have broadened the impact of scorpionate chemistry across bioinorganic modeling, homogeneous catalysis, and biorthogonal transformations. In particular, expanded tripodal scaffolds provide modular, tunable platforms for mimicking enzyme active sites and probing biological nitrogen fixation pathways. Beyond fundamental insight, these ligands present practical opportunities for sustainable catalysis by enabling …

Acute Correction Of Acquired Genu Valgum Secondary To Post-Traumatic Growth Arrest At The Time Of Distal Femur Fracture., Josiah Wolf, Nicholas Pelz, Adam Mansour, Christopher Iobst, Allen Kadado

Surgery Articles

A 14-year-old male patient sustained a distal femur fracture after a ground-level fall. His history was notable for severe acquired genu valgum secondary to a childhood lawnmower accident, which had required multiple limb salvage procedures including a Syme amputation and soft-tissue skin grafting. Acute correction of the limb deformity was performed concurrently with fracture fixation using a retrograde intramedullary nail and poller blocking screws. Retrograde intramedullary nailing represents a viable treatment option for simultaneous acute correction of acquired genu valgum and stabilization of distal femur fractures.

Apixaban Versus Rivaroxaban After Spontaneous Intracranial Hemorrhage In Atrial Fibrillation: A Propensity Score-Matched Trinetx Study., Muhammad Abdullah Naveed, Muhammad Omer Rehan, Hamayel Qadir, Muhammad Hasan, Syed Husain Farhan, Ahila Ali, Syed Ahmed Farhan, Maham Abbasi, Syed Shoreh Qazi, Wael Almahmeed, Sivaram Neppala, Muhammad Bilal Munir

Heart and Vascular Articles

BackgroundSurvivors of spontaneous intracranial hemorrhage (ICH) with atrial fibrillation (AF) face competing risks of thromboembolism and recurrent bleeding. Evidence directly comparing individual direct oral anticoagulants after resumption is limited.MethodsUsing the TriNetX Global Collaborative Network, we conducted a retrospective cohort study of adults with AF who restarted apixaban or rivaroxaban after spontaneous ICH. The index date was DOAC resumption, and cohorts were matched 1:1 using propensity scores. Recurrent spontaneous ICH was assessed at 30, 90, 180, and 365 days. One-year secondary outcomes were ischemic stroke, all-cause mortality, major bleeding, and gastrointestinal bleeding. Cox models produced hazard ratios (HRs) with 95% confidence …