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Articles 16441 - 16470 of 16857
Full-Text Articles in Medicine and Health Sciences
Fracture Resistance Of Resin Composite Restorations With Different Underlying Core Build Up Materials As A Dentin Substitute In Mod Cavities In Premolars (In-Vitro Study), Hend Sayed Ahmed, Mohamed Haridy, Hoda Fouda, Nourhan Kamel, Ahmed Refaat
Fracture Resistance Of Resin Composite Restorations With Different Underlying Core Build Up Materials As A Dentin Substitute In Mod Cavities In Premolars (In-Vitro Study), Hend Sayed Ahmed, Mohamed Haridy, Hoda Fouda, Nourhan Kamel, Ahmed Refaat
Dentistry
No abstract provided.
Effect Of Different Packing Protocols On Fracture Resistance Of Maxillary Premolars Restored With Bioactive Composite, Hend Sayed Ahmed, Mohamed Haridy, Hoda Fouda, Alaa Elgembri
Effect Of Different Packing Protocols On Fracture Resistance Of Maxillary Premolars Restored With Bioactive Composite, Hend Sayed Ahmed, Mohamed Haridy, Hoda Fouda, Alaa Elgembri
Dentistry
Abstract
Objectives: The aim of the present study was to verify effect of different packing protocols on fracture resistance of
maxillary premolar teeth with standardized mesioocclusodistal (MOD) preparations restored with bioactive composite.
Materials and Methods: Seventy sound maxillary premolar teeth with standardized MOD cavities were randomly
allocated to seven groups (n=10): G1 (control): sound teeth; G2: unrestored MOD preparation; G3: was filled by an
incremental technique with nanohybrid resin composite (Beautifil II LS, Shofu); G4: was filled in bulk with flowable
composite (Beautifil Bulk Flowable, Shofu); G5: bulk filled with nanohybrid composite (Beautifil Bulk, Shofu); G6: was
restored by increment …
Anticancer Effects Of A Captopril Montmorillonite Formulation In Oral Cancer Cells Through Apoptosis And Redox Modulation, Dalia Ghalwash, Nada Saleh, Hadeel Mousa, Shereen Raafat
Anticancer Effects Of A Captopril Montmorillonite Formulation In Oral Cancer Cells Through Apoptosis And Redox Modulation, Dalia Ghalwash, Nada Saleh, Hadeel Mousa, Shereen Raafat
Dentistry
Abstract Background Oral squamous cell carcinoma (OSCC) remains challenging due to the limited efficacy and toxicity of current therapies. This study investigates the anticancer potential of Captopril–Montmorillonite (CP–MMT) (nanoclay-based delivery system), a drug-repurposing approach in which Captopril is incorporated within MMT nanoclay layered silicate carrier. To our knowledge, this formulation has not been previously investigated in OSCC cell lines, demonstrating enhanced anticancer efficacy. The aim of the work was to compare the anticancer effects of CP–MMT formulation with free Captopril in OSCC cell lines, focusing on cytotoxicity, apoptosis, cell-cycle arrest, oxidative stress, and key molecular markers. Methods CP–MMT nanoclay-based formulation …
Clinical Feasibility Of An Artificial Intelligence- Assisted Digital Workflow For Full-Arch Implant Rehabilitation: A Multicenter Case Series, Dalia Ghalwash, Marco Tallarico, Mohamed El Ashry, Carlotta Cacciò, Mohamad Qaddomi
Clinical Feasibility Of An Artificial Intelligence- Assisted Digital Workflow For Full-Arch Implant Rehabilitation: A Multicenter Case Series, Dalia Ghalwash, Marco Tallarico, Mohamed El Ashry, Carlotta Cacciò, Mohamad Qaddomi
Dentistry
Fully digital workflows are increasingly used in implant prosthodontics; however, completely edentulous full-arch rehabilitations remain challenging because implant position transfer and passive framework fit are susceptible to cumulative scanning and registration errors. Clinical evidence on artificial intelligence (AI)-assisted completearch implant impression workflows remains limited. This multicenter case series aimed to describe the clinical feasibility of an AI-assisted digital workflow (SmartX) combined with extended scan bodies for all-on-X full-arch implant-supported rehabilitations. Ten completely edentulous patients rehabilitated with all-on-X implant-supported fullarch prostheses were included. Digital impressions were obtained using SmartFlag scan bodies and an AI-assisted SmartX workflow with an intraoral scanner. The …
Chia Seed Extract As A Potential Adjunct In The Management Of Oral Candidiasis: An In Vitro Study, Dalia Ghalwash, Rawda Sayed, Ahmed Ammar, Eman Khalil
Chia Seed Extract As A Potential Adjunct In The Management Of Oral Candidiasis: An In Vitro Study, Dalia Ghalwash, Rawda Sayed, Ahmed Ammar, Eman Khalil
Dentistry
ABSTRACT Background Oral candidiasis remains a common opportunistic fungal infection, with increasing interest in natural antifungal alternatives. This study aimed to evaluate the antifungal activity of Salvia hispanica (chia) seed extract against oral Candida albicans, compare its efficacy with nystatin, assess their combined effect, and investigate cytotoxicity on WI-38 human fibroblast cells. Methods Antifungal activity was evaluated using broth microdilution and agar well diffusion assays, with nystatin oral suspension used as a positive control. Cytotoxicity of chia seed extract was assessed on WI-38 human fibroblast cells using the MTT assay. Results Chia seed extract demonstrated notable antifungal activity, with a …
Prevalence And Oral Hygiene–Related Correlates Of Self-Reported Dentin Hypersensitivity Among Egyptian Adults: A Cross-Sectional Study, Dalia Ghalwash, Ahmed Hamdy, Ahmed Ammar, Shehad Wael, Alhassan Diab
Prevalence And Oral Hygiene–Related Correlates Of Self-Reported Dentin Hypersensitivity Among Egyptian Adults: A Cross-Sectional Study, Dalia Ghalwash, Ahmed Hamdy, Ahmed Ammar, Shehad Wael, Alhassan Diab
Dentistry
Abstract
Background
Dentin hypersensitivity (DH) is a prevalent clinical condition characterized by pain arising from exposed dentin in response to external stimuli. Despite its clinical relevance, epidemiological data from Egypt and the Middle East remain limited. This study aimed to assess the prevalence, symptom characteristics, and oral hygiene-related correlates of self-reported dentin hypersensitivity among Egyptians adults.
Methods
A cross-sectional questionnaire-based study was conducted among 370 Egyptian adults recruited from multiple governorates between January and August 2025. Data was collected using a structured questionnaire that underwent expert review, pilot testing, and reliability assessment. Information regarding self-reported dentin hypersensitivity, triggering stimuli, oral …
Prevalence Of Oral Mucosal Lesions Among Smokers Based On Gender: A Bicentric Cross-Sectional Study In Egypt, Dalia Ghalwash, Fatheya Zahran
Prevalence Of Oral Mucosal Lesions Among Smokers Based On Gender: A Bicentric Cross-Sectional Study In Egypt, Dalia Ghalwash, Fatheya Zahran
Dentistry
Abstract
Background
Smoking is a major risk factor for developing various types of oral mucosal lesions (OMLs), including benign and potentially malignant lesions. However, scarce data is available concerning gender differences regarding the prevalence of oral mucosal lesions in smokers worldwide. Accordingly, this study assesses the prevalence and types of OMLs among male smokers compared to female smokers in an Egyptian population.
Methods
This hospital-based cross-sectional study included 300 male and 300 female smokers. All participants underwent a thorough case history review and a comprehensive clinical examination.
Results
The overall prevalence of oral lesions was significantly higher in males (75%) …
Dentists’ Acceptance Of Artificial Intelligence-Assisted Decision Support For Oral Potentially Malignant Disorder Detection: A Structural Equation Modeling Study, Dalia Ghalwash
Dentistry
Abstract
Artificial intelligence (AI) may support early detection and clinical decision-making of oral potentially malignant disorders (OPMDs), but clinical implementation depends on dentists’ acceptance of AI-assisted clinical decision support. This study aimed to identify structural associations of AI acceptance among dentists using an extended Technology Acceptance Model (TAM). A cross-sectional survey was conducted among 500 dentists. Construct validity and reliability were assessed using confirmatory factor analysis. Hypothesized associations were evaluated using structural equation modeling with bootstrap mediation analysis. The extended TAM showed generally satisfactory measurement properties and good overall model fit. Attitude toward AI showed the strongest association with behavioral …
When Drug Repurposing Backfires: Antagonistic Effects Of Ivermectin On Cisplatin Therapy In Oral Cancer, Dalia Ghalwash, Rana Tantawy, Shereen Nader, Ayman Elgawish
When Drug Repurposing Backfires: Antagonistic Effects Of Ivermectin On Cisplatin Therapy In Oral Cancer, Dalia Ghalwash, Rana Tantawy, Shereen Nader, Ayman Elgawish
Dentistry
Abstract
Background
Cisplatin (CIS) remains the gold standard chemotherapeutic agent for the management of oral cancer. However, its clinical efficacy is frequently limited by chemoresistance and dose-dependent toxicities. Ivermectin (IVM), a well-established antiparasitic agent with emerging anticancer properties, has been proposed as a potential adjuvant capable of enhancing the antitumor efficacy of CIS.
Methods
In vitro experiments were conducted on HN9 oral squamous cell carcinoma cells, while OEC normal epithelial cells served as control. The experimental evaluation comprised the MTT assay for cell viability, Annexin V/propidium iodide (PI) staining for apoptosis detection, cell cycle distribution analysis, quantitative real-time PCR (RT-qPCR) …
Social Support As An Effect Modifier Of The Assocation Between Drug-Use Related Stigma And History Of Substance Use During Pregnancy Among Women Who Use Unprescribed Opioids In New York City: A Cross-Sectional Study, Isabelle C. Lynch
Graduate Studies Theses and Dissertations 2026
Substance use and misuse among women who are pregnant is a growing public health concern in the United States. Overdose deaths are now a leading cause of death among pregnant and postpartum women, and neonatal abstinence syndrome rates have increased to 23 per 1000 births. A barrier addressing substance use among these women is social stigma, which in part is driven by punitive drug policies that criminalize substance use during pregnancy and societal gender roles and norms surrounding women’s substance use. Social support, including emotional, instrumental, and informational support, can serve to mitigate the negative impacts of stigma on health …
Putting The L In Elsi: Legal Methods For Bioethics Research, Anya E R Prince, Benjamin Berkman, Donald Ford, Dov Fox, Christi Guerrini, Amy Koopmann, Natalie Ram, Jessica L Roberts, Kayte Spector-Bagdady, Sonia Suter
Putting The L In Elsi: Legal Methods For Bioethics Research, Anya E R Prince, Benjamin Berkman, Donald Ford, Dov Fox, Christi Guerrini, Amy Koopmann, Natalie Ram, Jessica L Roberts, Kayte Spector-Bagdady, Sonia Suter
Center for Medical Ethics and Health Policy Staff Publications
Lawyers and law professors are increasingly involved in interdisciplinary scientific teams and grant research to answer ethical, legal and policy questions related to biomedical topics. Yet, the methods that lawyers use to conduct legal research and analysis are not always familiar to scientists and social scientists conducting peer review of a proposed project with legal aims or a publication reporting a legal study. To better facilitate interdisciplinary ethical, legal, and social implications collaboration, there is a need to better explain how legal research methodologies can provide robust tools to address a range of nuanced biomedical questions. This paper explores …
Can I Get A Witness? The Ethical Dimensions Of Family Presence In Patient Suffering, Jennifer Blumenthal-Barby, Trevor M Bibler, Holland Kaplan, Adam Omelianchuk, Joanna Smolenski
Can I Get A Witness? The Ethical Dimensions Of Family Presence In Patient Suffering, Jennifer Blumenthal-Barby, Trevor M Bibler, Holland Kaplan, Adam Omelianchuk, Joanna Smolenski
Center for Medical Ethics and Health Policy Staff Publications
For patients who are suffering, the bedside presence of a family member can provide comfort, and many people hold that there is moral value in being present with a conscious, suffering patient. Yet what is the moral significance of the absence of family members when a patient is minimally conscious or unconscious and not aware of their absence? Clinicians are often troubled when family members and surrogate decision-makers who are able to spend a significant amount of time at an unconscious, seriously ill patient's bedside do not do so. Clinicians feel frustrated that they must bear the burden of witnessing …
Access To Digital Health Technologies: Personalized Framework And Global Perspectives, Sanjiv M Narayan, Mina K Chung, Demilade Adedinsewo, Luisa C C Brant, Leslie L Davis, David Duncker, Jennifer L Hall, Janet K Han, Carolyn S P Lam, Eldrin Lewis, Joseph Loscalzo, Manlio F Márquez, Vasiliki Rahimzadeh, Fatima Rodriguez, Prashanthan Sanders, Emma Svennberg, Kenneth Stein, Mintu Turakhia, Clyde Yancy, Antonis A Armoundas
Access To Digital Health Technologies: Personalized Framework And Global Perspectives, Sanjiv M Narayan, Mina K Chung, Demilade Adedinsewo, Luisa C C Brant, Leslie L Davis, David Duncker, Jennifer L Hall, Janet K Han, Carolyn S P Lam, Eldrin Lewis, Joseph Loscalzo, Manlio F Márquez, Vasiliki Rahimzadeh, Fatima Rodriguez, Prashanthan Sanders, Emma Svennberg, Kenneth Stein, Mintu Turakhia, Clyde Yancy, Antonis A Armoundas
Center for Medical Ethics and Health Policy Staff Publications
The emergence and rapid adoption of digital health technologies (DHT) present unprecedented opportunities to democratize and reduce disparities in health care by monitoring health and disease at the point of care in all patients. However, limited access to DHT is becoming a major obstacle to realizing these goals. Access to DHT is influenced not only by well-recognized social determinants of health, but also by digital determinants of health, such as digital literacy and the need for broad access to digital infrastructure, as well as commercial and economic factors. Addressing these challenges and designing unbiased systems of care are essential to …
Clinicians’ Views On A Patient Decision Aid For Deep Brain Stimulation In Parkinson’S Disease, Hillary S King, Jennifer Blumenthal-Barby, Benjamin H Levi, Sol De Jesus, Harini Sarva, Laura Y Cabrera
Clinicians’ Views On A Patient Decision Aid For Deep Brain Stimulation In Parkinson’S Disease, Hillary S King, Jennifer Blumenthal-Barby, Benjamin H Levi, Sol De Jesus, Harini Sarva, Laura Y Cabrera
Center for Medical Ethics and Health Policy Staff Publications
Introduction: For people with Parkinson's disease (PD), deciding whether to pursue deep brain stimulation (DBS) has become increasingly complex. Evidence suggests current approaches to collaborative decision-making may fall short of accepted standards. Thus, a decision support intervention, such as a patient decision aid (PtDA) may be warranted. PtDAs have been shown to improve patients' knowledge, expectations, and participation in decision-making for other, similar healthcare decisions. We therefore sought to assess neurologists' awareness of, and experience using, PtDAs, and to solicit their opinions on the ideal features of a PtDA for PD patients considering DBS.
Methods: Sixteen United States-based neurology clinicians …
Nanoparticle Albumin-Bound Paclitaxel And Nivolumab For Pd-1 Inhibitor-Refractory Recurrent Or Metastatic Head And Neck Squamous-Cell Carcinoma, Douglas Adkins, Jessica C Ley, Christine Auberle, Brendan Knapp, Jesse Zaretsky, Jingxia Liu, Peter Oppelt
Nanoparticle Albumin-Bound Paclitaxel And Nivolumab For Pd-1 Inhibitor-Refractory Recurrent Or Metastatic Head And Neck Squamous-Cell Carcinoma, Douglas Adkins, Jessica C Ley, Christine Auberle, Brendan Knapp, Jesse Zaretsky, Jingxia Liu, Peter Oppelt
2020-Current year OA Pubs
INTRODUCTION: Standard therapy for PD-1 inhibitor-refractory recurrent or metastatic head and neck squamous-cell carcinoma (RM-HNSCC) has limited activity. Drugs bound to albumin selectively target cancer cells with upregulated macropinocytosis, a process driven by constitutively hyper-activated EGFR/RAS/PIK3CA signaling, which is common in HNSCC. Nanoparticle albumin-bound (nab)-paclitaxel is active in PD-1 inhibitor-naïve RM-HNSCC and alters immune cells to potentially prime tumor response and reverse resistance to PD-1 inhibitors.
METHODS: In a single-arm phase 2 trial, patients with PD-1 inhibitor-refractory RM-HNSCC received nab-paclitaxel and nivolumab given in 28-day cycles. The primary endpoint was objective response rate (ORR), using RECIST1.1. Key secondary endpoints were …
Prediction Of Continuous Amyloid Positron Emission Tomography With Fluid Measures Of Phosphorylated Tau And Β-Amyloid, Niklas Mattsson-Carlgren, Linda Karlsson, Weizhong Tang, Kaj Blennow, Henrik Zetterberg, Randall J Bateman, Suzanne E Schindler, Nicolas Barthelemy, Sebastian Palmqvist, Erik Stomrud, Shorena Janelidze, Oskar Hansson
Prediction Of Continuous Amyloid Positron Emission Tomography With Fluid Measures Of Phosphorylated Tau And Β-Amyloid, Niklas Mattsson-Carlgren, Linda Karlsson, Weizhong Tang, Kaj Blennow, Henrik Zetterberg, Randall J Bateman, Suzanne E Schindler, Nicolas Barthelemy, Sebastian Palmqvist, Erik Stomrud, Shorena Janelidze, Oskar Hansson
2020-Current year OA Pubs
Brain amyloid-β (Aβ) pathology is a core feature of Alzheimer disease (AD) and can be quantified using positron emission tomography (PET). Cerebrospinal fluid (CSF) and plasma biomarkers detect abnormal Aβ, but it is unclear to what degree they can predict quantitative Aβ-PET. We explored plasma and CSF biomarkers in relation to Aβ-PET in the BioFINDER-2 study (N = 1053), and the BioFINDER-1 study (N = 238). We developed a machine learning pipeline to predict Aβ-PET using CSF and plasma measures. The best models achieved R
Application Of Machine Learning To Blood-Based Biomarkers Of Alzheimer's Disease In Down Syndrome, Patrick H Luckett, Melissa Petersen, Sid O'Bryant, Mark Mapstone, Brad T Christian, Benjamin Handen, Elizabeth Head, Beau M Ances, Alzheimer's Biomarker Consortium‐Down Syndrome
Application Of Machine Learning To Blood-Based Biomarkers Of Alzheimer's Disease In Down Syndrome, Patrick H Luckett, Melissa Petersen, Sid O'Bryant, Mark Mapstone, Brad T Christian, Benjamin Handen, Elizabeth Head, Beau M Ances, Alzheimer's Biomarker Consortium‐Down Syndrome
2020-Current year OA Pubs
INTRODUCTION: Blood-based biomarkers can improve Alzheimer's disease (AD) characterization in Down syndrome (DS). This study applied hierarchical clustering and machine learning-based feature selection to identify biomarkers associated with disease progression.
METHODS: Cross-sectional blood-based biomarkers were analyzed from 211 DS participants (
RESULTS: The strongest predictors overall were neurofilament light chain (NfL), tau/amyloid beta (Aβ)40, Aβ42/Aβ40, alpha-2-macroglobulin (A2M), and interleukin (IL)-10. Within the CS group, NfL, tau/Aβ40, A2M, and IL-10 were strong predictors. In MCI, Aβ42/Aβ40, NfL, A2M, and IL-10 were strong predictors. In DS-AD, Aβ42/Aβ40, NfL, and tau/Aβ40 were the top predictors. Cluster membership varied based on disease stage.
DISCUSSION: …
Perception Of Dementia Risk Among Black Adults: An Ecological Analysis Of Causal Loop Diagrams With A Structural And Social Determinant Of Health Composite Index, Jean-Francois Trani, Ramkrishna K Singh, Alexis Ib Walker, Semere Bekena, Yiqi Zhu, Ganesh M Babulal, Robbie Hart
Perception Of Dementia Risk Among Black Adults: An Ecological Analysis Of Causal Loop Diagrams With A Structural And Social Determinant Of Health Composite Index, Jean-Francois Trani, Ramkrishna K Singh, Alexis Ib Walker, Semere Bekena, Yiqi Zhu, Ganesh M Babulal, Robbie Hart
2020-Current year OA Pubs
INTRODUCTION: To investigate drivers of dementia risk disparities among older Black Americans using a community-based system dynamics (CBSD) approach.
METHODS: Over 18 months, 234 participants created 36 causal loop diagrams (CLDs) on dementia risk. An ecological analysis compared structural differences across groups based on scores on a structural and social determinants of health composite index (S/SDOH-CI).
RESULTS: Groups in the highest SDOH-CI quantile were more likely to identify key protective pathways linking mental health, substance use, exercise, medication, and community support to reduce dementia risk. In contrast, fewer than 25% of low-SDOH-CI groups identified these connections, and under 15% recognized …
Development Of Colonic Polyposis In A Woman With Chronic Myeloid Leukemia Treated With Dasatinib, Guido Pelaez, Behram Suha Yildiz, Mert Candan, Mohammad Ismail, Francesca Vacca, Marianna B Ruzinova, Samuel Ballentine, Kathleen Byrnes, Armin Ghobadi
Development Of Colonic Polyposis In A Woman With Chronic Myeloid Leukemia Treated With Dasatinib, Guido Pelaez, Behram Suha Yildiz, Mert Candan, Mohammad Ismail, Francesca Vacca, Marianna B Ruzinova, Samuel Ballentine, Kathleen Byrnes, Armin Ghobadi
2020-Current year OA Pubs
INTRODUCTION: Chronic myeloid leukemia (CML) is a hematopoietic malignancy driven by constitutive tyrosine kinase activity. Dasatinib, a second-generation (2G) tyrosine kinase inhibitor (TKI), is a preferred treatment due to its superior, durable, and rapid response rates. While dasatinib has known gastrointestinal (GI) side effects, colonic polyposis is a rare complication, not well described in the literature.
CASE PRESENTATION: Upon routine colonoscopy, a 66-year-old woman with chronic-phase CML was incidentally discovered to have asymptomatic colonic polyposis after 11 months of dasatinib therapy. Histopathology revealed reactive inflammatory changes without evidence of dysplasia or neoplasia. The polyposis resolved completely after cessation of dasatinib. …
Towards Precision Functional Brain Network Mapping In Parkinson's Disease, Jacob Chernicky, Ally Dworetsky, Sarah Grossen, Emma Carr, Abdulmunaim Eid, Meghan C Campbell, Caterina Gratton
Towards Precision Functional Brain Network Mapping In Parkinson's Disease, Jacob Chernicky, Ally Dworetsky, Sarah Grossen, Emma Carr, Abdulmunaim Eid, Meghan C Campbell, Caterina Gratton
2020-Current year OA Pubs
BACKGROUND: Parkinson's disease (PD) is a complex neurodegenerative condition that leads to widespread disruption of large-scale brain networks and is further complicated by substantial individual variability in symptomology, progression rates, and treatment response. Consequently, the investigation of individual differences in networks measured via resting state functional connectivity (RSFC) may provide insight. However, most RSFC studies are unable to identify interindividual differences due to poor reliability and group average network definitions. "Precision" RSFC addresses these shortcomings through extended data collection, strict denoising, and individual network definition, but remains untested in PD.
OBJECTIVES: To evaluate the feasibility and reliability of precision RSFC …
Treating Alzheimer's Disease In A Person Living With Hiv, David B Clifford, Tammie L S Benzinger, Jee-Young Han, Savannah Powles, Madeline Paczynski, Beau M Ances, J William Campbell
Treating Alzheimer's Disease In A Person Living With Hiv, David B Clifford, Tammie L S Benzinger, Jee-Young Han, Savannah Powles, Madeline Paczynski, Beau M Ances, J William Campbell
2020-Current year OA Pubs
INTRODUCTION: Human immunodeficiency virus (HIV) therapies now support survival into advanced ages by suppressing HIV replication and preserving immune function. Alzheimer's disease (AD), the most common neurologic degenerative condition, may now be treated with anti-amyloid therapies (AAT). HIV was an exclusionary criterion in clinical trials for AAT, leaving the safety and efficacy of these medications unknown in this setting.
METHODS: We report the development of AD supported by careful evaluations and biomarkers over a 10-year period in a person living with well-controlled HIV infection.
RESULTS: AD was diagnosed with consistent clinical and biomarker evidence. AAT was successfully administered without complications. …
Biological Aging Acceleration In Major Depressive Disorder: A Multi-Omics Analysis, Breno Satler Diniz, Shangshu Zhao, Gabin Drouard, Eero Vuoksimaa, Miina Ollikainen, Eric J Lenze, Ming Xu, Richard H Fortinsky, George A Kuchel, Jaakko Kaprio, Chia-Ling Kuo
Biological Aging Acceleration In Major Depressive Disorder: A Multi-Omics Analysis, Breno Satler Diniz, Shangshu Zhao, Gabin Drouard, Eero Vuoksimaa, Miina Ollikainen, Eric J Lenze, Ming Xu, Richard H Fortinsky, George A Kuchel, Jaakko Kaprio, Chia-Ling Kuo
2020-Current year OA Pubs
Major depressive disorder (MDD) is linked to a higher risk of premature aging, but the mechanisms underlying this association remain unclear. Using data from two population cohorts (UK Biobank and Finnish Twin Cohort), we evaluate the relationship between systemic and organ-specific proteomic and epigenetic aging acceleration and MDD. A lifetime history of MDD was associated with accelerated proteomic aging at both systemic and organ-specific levels-including the brain-in both cohorts, with stronger associations than those observed with systemic epigenetic aging. Systemic and brain-specific proteomic aging acceleration were linked to higher risks of incident MDD and a greater risk of Alzheimer's disease, …
Excellent Survival Following Low-Intensity Approaches Prior To Allo-Hsct In Ph+ All: A Comprehensive Meta-Analysis, Lacey S. Williams, Wenners Ballard Iii, Deniz Ozisik, Charles Scott Dorris, Kepher Makambi, Scott Rowley, Kieron Dunleavy, John Dipersio, Alaa Ali
Excellent Survival Following Low-Intensity Approaches Prior To Allo-Hsct In Ph+ All: A Comprehensive Meta-Analysis, Lacey S. Williams, Wenners Ballard Iii, Deniz Ozisik, Charles Scott Dorris, Kepher Makambi, Scott Rowley, Kieron Dunleavy, John Dipersio, Alaa Ali
2020-Current year OA Pubs
No abstract provided.
Novel Insights Into Early Alzheimer's Disease: Quantitative Gradient Recalled Echo Mri Reveals Preatrophic Neuronal And Myelin Injury Concurrent With Emerging Amyloid Pathology, Satya V V N Kothapalli, Tammie L S Benzinger, Randall J Bateman, Melody Li, Cihat Eldeniz, John C Morris, Dmitriy A Yablonskiy
Novel Insights Into Early Alzheimer's Disease: Quantitative Gradient Recalled Echo Mri Reveals Preatrophic Neuronal And Myelin Injury Concurrent With Emerging Amyloid Pathology, Satya V V N Kothapalli, Tammie L S Benzinger, Randall J Bateman, Melody Li, Cihat Eldeniz, John C Morris, Dmitriy A Yablonskiy
2020-Current year OA Pubs
BACKGROUND: Brain amyloid accumulation is considered an early sign of Alzheimer's disease (AD) pathology, appearing decades before manifestation of clinical symptoms. However, very little is known about neurodegeneration during this early AD stage. Herein we use quantitative gradient recalled echo (qGRE) magnetic resonance imaging (MRI) to reveal preatrophic microstructural neuronal and myelin damage concurrent with amyloid pathology.
METHODS: qGRE MRI and positron emission tomography (PET) amyloid [
RESULTS: qGRE detected significantly lower gray matter neuronal density and white matter myelination in the group of participants with amyloid level below the conventional amyloid-positive threshold (mean cortical standardized uptake value ratio of …
Comparison Of Positive Dysphotopsia Rates Between Au00t0, Mx60e, Pcb00/Zcb00, And Sn60wf Intraocular Lenses, Jonathan L. Tong, Maggie J. Xing, Arsham Sheybani
Comparison Of Positive Dysphotopsia Rates Between Au00t0, Mx60e, Pcb00/Zcb00, And Sn60wf Intraocular Lenses, Jonathan L. Tong, Maggie J. Xing, Arsham Sheybani
2020-Current year OA Pubs
No abstract provided.
The Association Between Major Depressive Disorder, Plasma Biomarkers Of Alzheimer's Disease, And Mild Behavioral Impairment Among Older Adults, Yiqi Zhu, Jean-Francois Trani, Ramkrishna K Singh, Semere Bekena, Jonathan Williams, Eric J Lenze, Ganesh M Babulal
The Association Between Major Depressive Disorder, Plasma Biomarkers Of Alzheimer's Disease, And Mild Behavioral Impairment Among Older Adults, Yiqi Zhu, Jean-Francois Trani, Ramkrishna K Singh, Semere Bekena, Jonathan Williams, Eric J Lenze, Ganesh M Babulal
2020-Current year OA Pubs
INTRODUCTION: Plasma biomarkers and mild behavioral impairment (MBI) are associated with dementia risk, but their relationships with major depressive disorder (MDD) are understudied. This study aimed to examine associations between plasma biomarkers of Alzheimer's disease (AD) and MBI among older adults with and without MDD.
METHODS: Older adults aged ≥65 were recruited from longitudinal studies of depression and AD (
RESULTS: Older adults with MDD were more likely to endorse MBI. After adjustment, Aβ42/Aβ40 and p-tau217/np-tau217 positivity were associated with MBI among those with MDD but not among those without.
DISCUSSION: Neuropsychatric symptoms (NPS) and biomarkers are AD risk factors. …
Reliability Of Remote Self-Administered Web-Based Digital Cognitive Measures And Comparison To In-Person Neuropsychological Tests: Stricker Learning Span, Symbols Test, And The Mayo Test Drive Screening Battery Composite, Morgan A Hughes, Jason Hassenstab, Et Al.
Reliability Of Remote Self-Administered Web-Based Digital Cognitive Measures And Comparison To In-Person Neuropsychological Tests: Stricker Learning Span, Symbols Test, And The Mayo Test Drive Screening Battery Composite, Morgan A Hughes, Jason Hassenstab, Et Al.
2020-Current year OA Pubs
INTRODUCTION: We describe the reliability of remote self-administered digital cognitive measures completed via the Mayo Test Drive (MTD) web-based platform.
METHODS: A total of 1846 participants (mean age = 70, SD = 12, range 31-101; 48% male; 96% White; 99% non-Hispanic; 97% cognitively unimpaired) with two to four complete MTD sessions at ∼7.5-month intervals were included. Test-retest reliability was assessed using single-rating, absolute-agreement, and two-way mixed intraclass correlation coefficients (ICCs) with 95% confidence intervals. ICCs for in-person-administered traditional neuropsychological measures were compared to MTD for a subset of 244 participants. Analyses also compared reliability across demographic, residential, and session context …
The Impact Of Congenital Heart Disease On The Timing Of Alzheimer's Disease In Down Syndrome, Julianne G Clina, Beau Ances, Et Al.
The Impact Of Congenital Heart Disease On The Timing Of Alzheimer's Disease In Down Syndrome, Julianne G Clina, Beau Ances, Et Al.
2020-Current year OA Pubs
INTRODUCTION: The incidence of Alzheimer's disease (AD) in Down syndrome (DS) exceeds 90%. Approximately 50% of people with DS have congenital heart disease (CHD). Having CHD increases risk for early-onset AD in populations without DS, but it is unclear if CHD influences AD in DS.
METHODS: Data from the Alzheimer Biomarker Consortium-Down Syndrome (ABC-DS) were used. Participants with CHD (
RESULTS: People with CHD scored lower for visuospatial ability (
DISCUSSION: Presence of CHD may influence AD progression in DS.
HIGHLIGHTS: In adults with Down syndrome (DS), those with congenital heart disease (CHD) had higher amyloid beta and reached the …
Antihypertensive Medications And Risk Of Alzheimer's Disease: Evidence For Specific Medication Use, Osvaldo J. Laurido-Soto, Alejandra Camacho-Soto, Irene M. Faust, Kassu M. Beyene, Aaron Katz, Jordan A. Killion, Brad A. Racette
Antihypertensive Medications And Risk Of Alzheimer's Disease: Evidence For Specific Medication Use, Osvaldo J. Laurido-Soto, Alejandra Camacho-Soto, Irene M. Faust, Kassu M. Beyene, Aaron Katz, Jordan A. Killion, Brad A. Racette
2020-Current year OA Pubs
No abstract provided.
Criterion And Convergent Validity Of Plasma Biomarkers In Early-Onset Alzheimer's Disease: Initial Findings From Leads, Dustin B Hammers, Kyle Womack, Erik Musiek, Et Al.
Criterion And Convergent Validity Of Plasma Biomarkers In Early-Onset Alzheimer's Disease: Initial Findings From Leads, Dustin B Hammers, Kyle Womack, Erik Musiek, Et Al.
2020-Current year OA Pubs
No abstract provided.