Medicine and Health Sciences Commons^™

Outcomes Of Acute Infective Endocarditis With Antibiotic Treatment In Cardiothoracic Surgery, Ella Amadio, James K. Wu Md, Bryan D. Nelson Mba, Cphq, Nrp

Research Scholars

No abstract provided.

Insufficient Pap Smear Results In Transgender Male Patients, Ella Choi, Patricia L. Mara Md

Research Scholars

No abstract provided.

Cholecystectomy Outcomes Following The Implementation Of Robotic Surgery At Lvh-M, Amber Unger, Kathryn L Wheel Md, Joseph J. Stirparo Md

Research Scholars

No abstract provided.

The Influence Of Renal Function On 30-Day Post-Coronary Artery Bypass Graft Surgery Readmissions, Hanna Sumner, Rosemarie Incorvaia, Bryan D. Nelson Mba, Cphq, Nrp, James K. Wu Md

Research Scholars

No abstract provided.

Quality Improvement Project To Increase Utilization Of Oral Step-Down Therapy For Prosthetic Joint Infections (Pji), Juliane Kallenbach, Amy Slenker Md

Research Scholars

No abstract provided.

Emergency Department (Ed) Patients With A Sepsis Alert Discharged With A Prescription For Oral Antibiotics, Mckenna Dempsey, Jarrod W. Kile Rphd, Megan Taylor Pharmd, Eric Young Md

Research Scholars

No abstract provided.

Commonalities Of 30-Day Readmitted Coronary Artery Bypass Graft Surgery Patients, Rosemarie Incorvaia, Hanna Sumner, James K. Wu Md, Bryan D. Nelson Mba, Cphq, Nrp

Research Scholars

No abstract provided.

Patient Education: A Multidisciplinary Model At Lehigh Valley Health Network (Lvhn), Part Of Jefferson Health, Morgan Strecker, Lisa Keller Med

Research Scholars

No abstract provided.

The Effect Of Lab Processing On Turn Around Time In The Emergency Department, Brianna Andersen, Kathleen E. Kane Md, Shelbi Taylor Msn, Mba, Rn-Bc

Research Scholars

No abstract provided.

Connecting The Community In Research – Through A Community-Based Participatory Research Approach, Ava Fortner, Nicole M. Burgess, Autumn Kieber-Emmons Md, Mph, Ashwini Kamath Mulki Md, Mbbs, Mph

Research Scholars

No abstract provided.

Rationale For Pre-Procedure Dental Interventions To Enhance Medical Outcomes, Harsha Pamulapati, Rebecca Frank Rdh, Phdhp, Michele Pisano-Marsh Dmd

Research Scholars

No abstract provided.

Implementing The Lehigh Valley Health Network’S Junior Research Scholar (Jrs) Program: Mentoring At The Secondary Level, Magdalene Burnham, Lisa Keller Med

Research Scholars

No abstract provided.

The Effect Of Intravenous Contrast On Creatinine In The Emergency Department, Brianna Andersen, Kathleen E. Kane Md

Research Scholars

No abstract provided.

Exploring The Intersection Of Healthcare And Climate Change With A Socio-Ecological Model Approach, Shae Billmyer, Ashwini Kamath Mulki Md, Mbbs, Nyann Biery Ms, Dhsc, Lynn M. Wilson Do

Research Scholars

No abstract provided.

Linking Curiosity To Career: A Master Adaptive Approach To Resident Elective In Family Medicine Training, Shayna Blikshteyn, Drew Keister Md, Karla J Felix Phd

Research Scholars

No abstract provided.

Impact Of Prostate Volume On Dose Fall-Off And Organ-At-Risk Exposure In Vmat For Prostate Cancer, Zhikang Jiang

Masters Projects

Prostate cancer remains one of the most prevalent malignancies among men, with radiotherapy, particularly VMAT—playing a central role in its management. VMAT allows for highly conformal dose delivery, but treatment planning must strike a careful balance between achieving steep dose gradients around the prostate and minimizing radiation exposure to nearby organs at risk (OARs), such as the bladder and rectum. This study aimed to evaluate how prostate volume influences dose fall-off characteristics and OAR dose exposure in VMAT treatment plans, providing insights into optimizing radiotherapy for patients with varying prostate sizes. A retrospective analysis was conducted on 50 prostate cancer …

An Experimental Investigation Of Federal Messaging On Public Support For Enforcement- And Treatment-Based Approaches For Opioid Overdose Prevention In South Carolina, Lídia Gual-Gonzalez, Hunter M. Boehme, Peter Baker, Melissa Nolan Ph.D., Mph

Faculty Publications

Background

As the opioid overdose crisis continues to produce excessive morbidity and mortality in the United States, government agencies have applied various approaches to prevent overdoses, including law-enforcement efforts (e.g., arresting people who use drugs, interrupting drug traffickers, etc.) and treatment-based approaches (e.g., naloxone, medications for opioid use disorder, etc.). Public perception and support of these approaches are relevant for informing policy, allocating resources, and effectively implementing community interventions to prevent drug-related harms.

Methods

Using an embedded informational survey design, we experimentally assessed whether public support for strategies to prevent overdose in South Carolina is influenced by language from federal …

Impact Of Food Insecurity Resource Navigation For Primary Care Patients With Diabetes And Hypertension: A Matched Cohort Study, Deeksha Gupta, Darin Thomas, Stella Self, Edward A. Frongillo Jr. Ph.D., Alain H. Litwin, J. Alex Ewing, Lynnette Ramos-Gonzalez, A. Carolina Rudisill

Faculty Publications

Background

Food insecurity contributes to poor health and increased healthcare costs among patients with chronic diseases. Resource navigators can facilitate community-based resource connections, addressing food insecurity, but the impact on healthcare costs and quality of life remains unclear.

Objective

To examine whether food insecurity resource navigation improves clinical outcomes, healthcare charges, and quality of life for patients with diabetes and/or hypertension.

Design

Matched-control quasi-experimental study.

Patients

Patients underwent screening for food insecurity from July 12, 2021, to December 31, 2022, in South Carolina’s largest health system. Eligible patients (18 + years, having food insecurity, and diabetes and/or hypertension) enrolled for …

Application Of Nova & Denova For Use Of Tee On Patients With E. Faecalis Bacteremia, Chideraa Emma-Ugwuoke, Sameer Rahman, Raul E Davaro Md

Research Scholars

No abstract provided.

Comparing Concussion Recovery Rates Over Time, Francesca Andronic Md, William Kane, Daniele Shollenberger Crnp, Mark Cipolle Md

Research Scholars

No abstract provided.

Impact Of Virtual Visits On Antibiotic Prescribing For Upper Respiratory Infections, Anna Mikulski, Jarrod W. Kile Rphd, Brooke Broczkowski Pharmd, Kathryn Zaffiri Mph, Eric Young Md

Research Scholars

No abstract provided.

Concordance Of Management Of Early And Locally Advanced Esophageal And Esophagogastric Junction Tumors With National Comprehensive Cancer Network Guidelines, Kanchan Gupta, Melissa Kratz Rn, Msn, Aocn, Sean Quinlan-Davidson Md, Savitri Skandan Md

Research Scholars

No abstract provided.

Comparing Concussion Recovery Between Men And Women Using Vision Therapy, Peter Kozloff, Francesca Andronic Md, Daniele Shollenberger Crnp, Mark Cipolle Md

Research Scholars

No abstract provided.

Focused Rapid Assessment Process (Frap) 3.0: A Community-Led, Train-The-Trainer Model For The National Diabetes Prevention Program For Local Spanish-Speaking Adults, Rachel Apiolaza, Carolyn Peterseim Md, Miguel Chuidian Md

Research Scholars

No abstract provided.

Assessing The Inpatient Utility Of Echocardiography And Its Clinical Impact, Briana Prieto, Shuisen Li Do

Research Scholars

No abstract provided.

Long Term Outcomes Of Dermal Substrate Treated Burns And Wounds, Sarvesh Senguttunvan, Sigrid A. Blome-Eberwein Md

Research Scholars

No abstract provided.

Adaptive Bayesian Clinical Trials: The Past, Present, And Future Of Clinical Research, Donald A Berry

Faculty, Staff and Student Publications

Background/Objectives: Decision-analytic Bayesian approaches are ideally suited for designing clinical trials. They have been used increasingly over the last 30 years in developing medical devices and drugs. A prototype trial is a bandit problem in which treating participants is as important as treating patients in clinical practice after the trial.

Methods: This article chronicles the use of the Bayesian approach in clinical trials motivated by bandit problems. It provides a comprehensive historical and practical review of Bayesian adaptive trials, with a focus on bandit-inspired designs.

Results: The 20th century saw advances in Bayesian methodology involving computer simulation. In the …

Distinct Clinicogenomic Features And Immunotherapy Associations In Pulmonary Sarcomatoid Carcinoma: A Multicenter Retrospective Study, Lingzhi Hong, Alessandro Di Federico, Bolun Liu, Alissa J Cooper, Joao V Alessi, Phoebe Clark, Waree Rinsurongkawong, Chingyi Young, Hui Li, Kang Qin, Muhammad Aminu, Valentina Santo, Yasir Elamin, Boris Sepesi, Jeff Lewis, Don L Gibbons, Ara A Vaporciyan, J Jack Lee, Xiuning Le, Jia Wu, Sinchita Roy-Chowdhuri, Mark J Routbort, P Andrew Futreal, John V Heymach, Mark M Awad, Adam J Schoenfeld, Jianjun Zhang, Biagio Ricciuti, Lei Deng, Natalie I Vokes

Faculty, Staff and Student Publications

Introduction: Pulmonary sarcomatoid carcinoma (PSC) is a rare NSCLC subtype with poor prognosis. Outcomes to immune checkpoint inhibitors (ICIs) and genomic features in PSC remain underexplored compared with other NSCLC subtypes.

Methods: Patients from three institutions and the National Cancer Database (NCDB) with metastatic NSCLC treated with ICI alone or with chemotherapy were identified. Clinicogenomics and treatment outcomes were compared across PSC, lung adenocarcinoma (LUAD), and lung squamous cell carcinoma (LUSC).

Results: We analyzed 4841 patients including 165 PSC cases treated with ICI-based therapy from three institutions and 201 PSC from NCDB. In MDACC, 65 (4.3%) were PSC, 1138 (75.1%) …

Il-6 Predicts Cdk4/6 Inhibitor Resistance, Identifying Stat3 As A Target In Hr + /Her2-Negative Metastatic Breast Cancer, Nicole M Kettner, Tuyen N Bui, Juliana Navarro-Yepes, Sanaz Ghotbaldini, Bethanie Quintela, Catherine K Luo, Nghi Lam, Xiayu Rao, Akshara Singareeka Raghavendra, Yan Wang, Nancy Azizian, T Kris Eckols, Moses Makokha Kasembeli, Kurt Evans, Min Yi, Hannah Wingate, Jing Wang, Aysegul A Sahin, Funda Meric-Bernstam, Kelly K Hunt, Senthil Damodaran, David J Tweardy, Debu Tripathy, Khandan Keyomarsi

Faculty, Staff and Student Publications

Resistance to CDK4/6 inhibitors (CDK4/6i) is a major challenge in treating hormone receptor-positive, HER2-negative metastatic breast cancer. This study aimed to identify a biomarker predictive of resistance that could also serve as a therapeutic target. Circulating IL-6 levels in 166 patients significantly increased at progression, making IL-6 a non-invasive biomarker to predict CDK4/6i resistance. Knockdown of IL-6 re-sensitized resistant cells to palbociclib and endocrine therapy, underscoring IL-6's critical role in maintaining resistance. Patient-derived xenograft models from patients who progressed within 3 months versus ≥6 months of palbociclib therapy revealed distinct transcriptomic profiles, with later progressors exhibiting IL-6/STAT3 activation, epithelial-to-mesenchymal transition, …

Human Ipsc-Based Breast Cancer Model Identifies S100p-Dependent Cancer Stemness Induced By Brca1 Mutation, Jingxin Liu, Cai Zhao, Jiahao Chen, Pengguihang Zeng, Qingjian Li, Ranran Dai, Xingqiang Lai, Wenqian Song, Jianing Chen, Xixi Zhu, Xinyi Liu, Jun Sun, Jia Wang, Peihang Fang, Tengfei Wang, Wenjie Chen, Diana Guallar, Nan Cao, Jianli Zhao, Shicheng Su, Andy Peng Xiang, Yi Arial Zeng, Jie Li, Junchao Cai, Dung-Fang Lee, Jinxin Bei, Yongliang Huo, Hai Hu, Shengbao Suo, Dong-Feng Huang, Jin Bai, Junjun Ding

Faculty, Staff and Student Publications

Breast cancer is the most common malignancy in females and remains the leading cause of cancer-related deaths for women worldwide. The cellular and molecular basis of breast tumorigenesis is not completely understood partly due to the lack of human research models which simulate the development of breast cancer. Here, we developed a method for generating functional mammary-like cells (MCs) from human-induced pluripotent stem cells (iPSCs). The iPSC-MCs closely resemble human primary MCs at cellular, transcriptional, and functional levels. Using this method, a breast cancer model was generated using patient-derived iPSCs harboring germline