Medicine and Health Sciences Commons^™

Low-Impact Functioning Autism And Psychotropic Medications, Angela N. Butler

Doctoral Dissertations and Projects

From the onset of the discovery of its existence, studies provided additional information pertaining to autism spectrum disorder (ASD), its influences on a child’s growth, everyday performance, including the capability to interrelate with people. Studies on appropriate medications to prescribe to ASD youth have yielded questionable results. Objective: This study’s purpose was to address adverse effects as an overall issue and re-evaluation of the psychotropic medications prescribed to Low-Impact ASD (LIASD) youth. Additionally, this study examined the process of diagnosing and supporting the reclassification of autism. Method: A mixed-methods design was employed, to review prescribed medications and determine the relationship …

Self-Efficacy And Burnout Of Nursing Faculty: The Mediating Role Of Fear Of Negative Evaluation, Sarah Murray Kelly

Doctoral Dissertations and Projects

The contents of this manuscript include a dissertation of a survey research study using the theoretical models of self-efficacy and burnout. The quantitative study used mediation analysis to explore the relationship between self-efficacy and burnout, with fear of negative evaluation as a mediator. Fear of negative evaluation was measured using the Brief Fear of Negative Evaluation Scale-Revised; self-efficacy was calculated using the General Self-Efficacy Scale; and burnout was measured using the Oldenburg Burnout Inventory. The study drew a sample of 98 academic nurse educators (N = 98) who were evaluated by student evaluations of teaching. The sample included educators who …

Enhancing Parental Knowledge Of Functional Medicine Interventions For Adhd: An Educational Initiative To Improve Caregiver Competency, Julie Gammer

Doctoral Dissertations and Projects

Attention-Deficit/Hyperactivity Disorder (ADHD) is a prevalent pediatric psychiatric condition often managed with stimulant medications that carry potential side effects and may not address underlying causes. Research findings indicate a significant gap in caregiver knowledge and confidence in treating their child's ADHD with functional medicine strategies. This project develops an evidence-based educational initiative designed to enhance caregiver knowledge and confidence in applying functional medicine interventions—such as dietary modifications, targeted supplementation, and gut health restoration—as natural, root-cause approaches to managing ADHD symptoms. The project utilized a 30-minute audiovisual presentation and was evaluated using pre- and post-intervention competency tests, as well as a …

Investigating “Sled Head” Phenomenon And Diurnal Patterns In Team Usa Bobsleigh And Luge Athletes: A Virtual Research Study, Garrett R. Augsburger

Doctoral Dissertations and Projects

This study investigated the relationship between training time, performance, and concussion symptoms among Team USA bobsleigh and luge athletes during a four-week training season. Recognizing the high physical demands and potential risks associated with sledding sports, the study aimed to understand the prevalence of concussion-related experiences and how training schedules might influence athletic performance and symptomology. Repeated measures quantitative design was employed using session-level survey data submitted by athletes following daily training sessions. Data was collected through a structured questionnaire assessing variables such as performance rating, fatigue, alertness, training intensity, sleep quality, and concussion symptoms. A total of 156 sessions …

Decreasing The Incidence Of Healthcare Associated Presure Injuries In The Acute Care Setting, Amanda R. Nichols

Doctoral Dissertations and Projects

Healthcare-associated pressure injuries (HAPIs) can cause great harm to vulnerable patients. Acquiring a HAPI during hospitalization can result in delayed wound treatment, prolonged hospitalization, risk for infection, reimbursement issues for the facility, and delayed patient discharge. Avoiding these injuries is essential to improve patient outcomes. Research reveals that the implementation of nurse education and two registered nurse skin assessments on admission, instead of one nurse skin assessment, can decrease the incidence of healthcare-associated pressure injuries. Using the Iowa model, the goal of this scholarly project is to implement evidence-based research to change the current process and decrease the incidence of …

An Analysis Of The Health Disparities For Traumatic Brain Injury Care In Urban Vs. Rural Populations, Jeremy R. Russell

Doctoral Dissertations and Projects

The purpose of this quantitative research study was to examine how disparities between urban and rural environments impacted the amount, onset, and duration of care received by patients with mild traumatic brain injury, as well as differences in demographic characteristics such as age and gender. Mild TBIs, often referred to as concussions, involve a temporary disruption in brain function resulting from external force, leading to symptoms like confusion, dizziness, or memory issues. Guided by critical theory, this study explored how systemic structures contributed to unequal healthcare experiences. Since TBIs remained a leading cause of disability and death with potential long-term …

The Effects Of The Menstrual Cycle On Movement Velocity In Female Athletes, Casey M. Krolikowski

Doctoral Dissertations and Projects

This study examined the psychological and physiological impacts of menstrual cycle phase and hormonal contraceptive (HC) use on barbell back squat and bench press velocity, handgrip strength, and countermovement jump height. The aim was to determine whether HC use and premenstrual syndrome (PMS) symptoms affected performance during menstruation, the late follicular phase (LFP), or the mid-luteal phase (MLP). Fourteen college-aged female athletes (N = 14) were divided into HC users (n = 7), and naturally menstruating, eumenorrheic individuals (n = 7). Movement velocity data was assessed using RepOne linear position transducers, jump height with the Just Jump mat, and grip …

Social Media And Mental Health According To Generation Z: A Health Belief Model-Based Cross-Sectional Evaluation Of Generation Z Adults’ Attitudes And Perceptions Of Problematic Social Media Use And Its Relationship With Depression And Anxiety, Michael Chad Gann

Doctoral Dissertations and Projects

Purpose: This study aimed to examine Generation Z adults’ attitudes and perceptions of problematic social media use (PSMU) as they relate to mental health problems (depression and anxiety) through the lens of the Mental Health Belief Model.

Methods: A cross-sectional, web-based survey gathered data from a convenience sample (N = 353) of Generation Z adults (age 18-30) after receiving approval from the LU IRB. The previously validated instrument battery included the Bergen Social Media Addiction Scale (BSMAS), the Patient Health Questionaire – 9 (PHQ-9), the Generalized Anxiety Disorder – 7 (GAD-7), and the Greene (2012) MHBM subscales for perceived susceptibility …

Evaluating Mental Health Providers’ Knowledge And Attitudes Towards Stigma Among Teenagers Aged 13 To 19 Years With Mental Illness, Fredrica Murray-Johnson

Doctoral Dissertations and Projects

Limited knowledge and poor attitudes among mental health providers contribute to stigma towards individuals with mental illness, adversely affecting treatment experience and outcomes. This study evaluated the effectiveness of an educational intervention in improving mental health providers’ knowledge and attitudes toward stigma-based practices. The clinical question stated: Among mental health providers, does an educational intervention, compared to standard practice, improve knowledge and attitudes of stigma and promote evidence-based care delivery to teenagers aged 13 to 19 with mental illness within six weeks? The Iowa Model of Evidence-Based Practice (EBP) was used as a framework for implementing this study. The quasi-experimental …

Evaluating Inclusion Rates Of Oral-Systemic Health Connection Coursework In Dental And Medical Professional Programs' Admissions Requirements, Wendy Marie Carry

Doctoral Dissertations and Projects

Oral systemic health connections (OSHC) are bidirectional, life-threatening, and a significant public health concern. Studies have identified over 200 OSHCs; however, the prevalence of foundational OSHC education in dental and medical professional programs remains unknown. This quantitative descriptive comparative pilot study aimed to explore the prevalence of predictor variables, dental and medical professional programs in the United States, and the criterion variable, including an OSHC admissions requirement for the 2025 academic year. The point-in-time count methodology served as the theoretical framework guiding this study and the development of the PiT-PARCI instrument. The proposed testing was replaced with alternative testing based …

Experiences Of First-Generation Nursing Students After Their First Year At An Hbcu: A Transcendental Phenomenological Study, Ari L. Cuffee

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to explore the lived experiences of first-generation nursing students (FGNS) after their first year at a Historically Black College or University (HBCU). The central research question asked, “What are the lived experiences of first-generation nursing students who have completed one year at a Historically Black University?” The theoretical framework that guided this study was Banks’ theory of multicultural education. This theory demonstrated how educators taught FGNS using the multicultural education paradigm with strategies and procedures to make provisions for culturally, racially, and ethnically diverse students. Data were analyzed using Moustakas’ interpretive phenomenological …

Opiate Addiction Crisis In The United States, Autumn Joy Collins

Doctoral Dissertations and Projects

This research investigates how fentanyl has influenced drug trafficking trends and the corresponding response from law enforcement in New York State. It aims to explore the changes in drug trafficking pathways, organizational structures, and methods in this region since fentanyl's emergence and how state law enforcement has adjusted to this new challenge. The study uses a quantitative methodology, analyzing various data from law enforcement records, court documents, and state government reports. The focus is on fentanyl-related drug trafficking cases in New York State over five years. Methods include examining case records and analyzing trafficking patterns statistically. The study will assess …

Passing The Torch: Evaluating Documentation Quality And Its Impact On Nurses’ Perceptions Of Communication Across Va Care Transitions, Shannon Collier Baker

Doctoral Dissertations and Projects

Effective communication during transitions of care is crucial to ensuring patient safety and optimizing outcomes. However, current practices may fall short in supporting clear and comprehensive communication among healthcare providers, particularly during complex care transitions involving Veterans who have received targeted care coordination intervention outside of their primary Patient Aligned Care Team. The absence of standardized tools for handoff documentation exacerbates fragmented communication and ambiguity about the transfer of care management responsibilities, potentially leading to avoidable errors and care coordination failures. This project aimed to investigate nurses' perceptions of the adequacy of communication during the transition of moderate to complex …

An Analysis Of Sport Science Practices And Standards In Collegiate Football, Corey F. Fitzgerald

Doctoral Dissertations and Projects

This dissertation presents the findings of a survey that identifies the sport science practices and standards utilized in National Collegiate Athletic Association (NCAA) football programs. In total a fifty-two item survey instrument was administered that examines seven sections, including (i) demographics, (ii) current sport science practices, (iii) advanced technology, (iv) decision-making processes, (v) health and wellness, (vi) budget and resources, and (vii) comments. All generated numerical data was organized into a statistical analysis program, SPSS Statistics v 29.0.2.0 (© IBM Corporation). Correlations were conducted on data gathered from Likert Scale questions, using Spearman test. Additionally, comprehensive non-numerical subjective data was …

Exploring The Effectiveness Of Wearable Devices For Early Disease Detection, Chinonso Iwummadu

Doctoral Dissertations and Projects

The purpose of this qualitative interpretive phenomenological study was to explore the perceived effectiveness of wearable devices in facilitating early disease detection among patient groups, healthcare professionals, and healthcare administrators in the outpatient care setting. The central phenomenon investigated, involved the experiences, perceptions, and behavioral responses toward real-time monitoring and diagnostic engagement enabled by wearable devices. The theory that guided the study was the Health Technology Acceptance Model (HTAM), which supported inquiry into how perceived usefulness, perceived ease of use, and perceived health outcomes shaped adoption behavior and clinical integration of digital tools. Data were collected from a purposive sample …

Governance Of Polygenic Embryo Screening: A Qualitative Study On The Perspectives Of Clinicians And Patients, Jason Bach, Jonathan Frumovitz, Dorit Barlevy, Rémy A Furrer, Abigail Martinez, Ana Battaglino, Shai Carmi, Todd Lencz, Gabriel Lázaro-Muñoz, Stacey Pereira

Center for Medical Ethics and Health Policy Staff Publications

Objective: To investigate the perspectives of stakeholders on their attitudes toward potential regulation of polygenic embryo screening (PES), a new form of preimplantation genetic testing that is used to screen embryos for the genetic chances of developing medical conditions and nonmedical traits involving hundreds or thousands of genes.

Design: We conducted individual, semistructured interviews and analyzed transcripts using thematic analysis.

Subjects: Twenty-seven US-based reproductive endocrinology and infertility specialists and 26 patients who were currently undergoing in vitro fertilization or had within the past five years.

Main outcome measures: Repeating ideas and patterned responses were organized into themes and subthemes.

Results: …

The Caribbean American Dementia And Aging Study: Protocol For A Population-Based Study Of Older Adult Health And Dementia In Cuba, The Dominican Republic, And Puerto Rico, Mao-Mei Liu, Jorge Llibre-Guerra, Chris Soria, Jing Li, Tania Zayas Llerena, Guillermina Rodriguez, Daisy Acosta, Ivonne Jiménez Velázquez, Juan J Llibre-Rodriguez, William H Dow

2020-Current year OA Pubs

BACKGROUND: The Hispanic Caribbean region is rapidly aging but national population-based aging surveys are rare. The Caribbean American Dementia and Aging Study (CADAS) is a multi-purpose household study of aging with a particular focus on the life course determinants and consequences of health and dementia in three countries with many similarities but divergent recent histories: Puerto Rico, Dominican Republic, and Cuba. METHODS: CADAS will survey population-based samples of adults ages 65 and over. In Puerto Rico and Dominican Republic these will be nationally representative samples of 1,500 adults each; the Cuban survey will include 1,500 adults from purposively selected urban …

Excitotoxic Neuronal Death Requires Superoxide Entry Into Neurons Through Volume-Regulated Anion Channels, Kate Harris, Seok Joon Won, Gokhan Uruk, Nguyen Mai, Devran Ogut, Yonghui Zhao, Litao Xie, Paul Baxter, Katharina Everaerts, Rajan Sah, Raymond A Swanson

2020-Current year OA Pubs

Neuronal death in stroke and other conditions stems in part from stimulation of

Prefoldin Complex Promotes Interferon-Stimulated Gene Expression And Is Inhibited By Rotavirus Vp3, Yinxing Zhu, Yanhua Song, Dilip Kumar, Peter K Jackson, B V Venkataram Prasad, Siyuan Ding

2020-Current year OA Pubs

Timely induction of interferons and interferon-stimulated genes (ISGs) is critical for successful host defense against viral infections. VP3 encoded by rotavirus is implicated in interferon antagonism. However, the precise mechanisms remain incompletely understood. By conducting tandem-affinity purification coupled with high-resolution mass spectrometry, we identify the prefoldin complex as the top cellular binding partner of VP3. Rotavirus infection is significantly enhanced in prefoldin subunit knockout cells. Using proteome-wide label-free quantification, we find that prefoldin assists in folding ubiquitin-like-modifier-activating-enzyme-3 (UBA3), both of which positively regulate ISG expression. Through direct and competitive binding, VP3 interferes with the chaperone activity of prefoldin, leading to …

Adapt-3d: Accelerated Deep Adaptable Processing Of Tissue For 3-Dimensional Fluorescence Tissue Imaging For Research And Clinical Settings, Daniel D Lee, Kevin A Telfer, Deanna L Davis, Leon C D Smyth, Rahul Ravindran, Rafael S Czepielewski, Christopher G Huckstep, Siling Du, Kento Kurashima, Ajay K Jain, Jonathan Kipnis, Bernd H Zinselmeyer, Gwendalyn J Randolph

2020-Current year OA Pubs

Light sheet microscopy and preparative clearing methods that improve light penetration in 3D tissues have revolutionized imaging in biomedical research. Here we present ADAPT-3D, a streamlined 3-step approach to turn tissues optically transparent while preserving tissue architecture with the versatility to handle diverse tissue sizes and types across species. Unlike extensive lipid removal utilized by existing protocols, ADAPT-3D only partially removes lipids to preserve cell membranes, yet the non-toxic aqueous refractive indexing solution still rapidly turns tissues transparent while preserving the fluorescence of endogenous and antibody conjugated fluorophores. ADAPT-3D prepares whole mouse brains for light sheet microscopy in a 4-hour …

Whf Roadmap On Single Pill Combination Therapies, Enrico G Ferro, Mark Huffman, Orly Vardeny, Et Al.

2020-Current year OA Pubs

Cardiovascular diseases (CVDs) are the leading global cause of mortality, with treatment adherence posing a major barrier to effective prevention and control. Single pill combinations (SPCs), also known as fixed-dose combinations, simplify treatment by combining multiple agents into one pill, improving adherence and reducing cardiovascular risk. This World Heart Federation Roadmap synthesizes the latest clinical evidence and identifies key barriers to SPC implementation, including limited manufacturing, affordability, regulatory complexity, and inconsistent guideline inclusion. Drawing on global expert input and health systems analysis, the Roadmap outlines practical, context-specific solutions to improve access, scale-up, and integration of SPCs into national strategies, especially …

Investigating Extracellualr Vesicles Role In The Pathogenesis Of Acute Lung Injury, Ruben Manuel Luciano Colunga Biancatelli, Pavel Solopov, Tierney Day, Anca Dobrian, John D. Catravas

Cardiovascular Research Symposium

Background: Extracellular vesicles (EVs) are small lipid-bound particles containing proteins and RNAs, whose role in intercellular communication and signaling is critical for homeostasis or inflammatory responses. Patients with acute lung injury display changes in EVs number, cargo content and signature compared to healthy individuals.

Hypothesis: We have hypothesized that EVs may play a role in the pathogenesis of acute lung, by transferring harmful mediators of inflammation and disrupting recipient cells homeostasis.

Methods: C57BL/6j mice (8-10 weeks old, 25g BW) were intratracheally instilled with 50µL of 5*1010- 11 EVs isolated from Human Lung Microvascular Endothelial cells (HLMVEC) exposed to 1 µg …

Characteristics And Outcomes Of Axillary And Subclavian Artery Injuries, Benjamin Samberg, Nicholas Bandy, Michael Martyak

Cardiovascular Research Symposium

INTRODUCTION: Subclavian and axillary artery injuries are rare but life-threatening. Optimal management strategies remain debated. This study compares injury characteristics and outcomes.

METHODS: Retrospective analysis was conducted on 181 PROOVIT Database patients categorized by injury location, mechanism, and treatment (open, endovascular, nonoperative). Collected data includes ISS, PRBC, mortality, hospital and ICU LOS, and hard signs.

RESULTS: Subclavian injuries had higher ISS (μ=25, 19; p=0.004) and mortality (18%, 3.4%; p=0.004), but fewer hard signs (41%, 63%; p=0.004) than axillary. Axillary injuries were more frequently treated with open repair (51%, 32%; p=0.016), while subclavian injuries were more often managed nonoperatively (45%, 29%; …

B Cell Subset Specific Regulation Via Desmosterol In An Atherosclerotic Environment, Shelby Ma, Alina Morty, Kathleen Coleman, Basudha Habisyasi, Elena Galkina

Cardiovascular Research Symposium

No abstract provided.

New Onset Heart Failure Of Sodium-Glucose Cotransporter 2 (Sglt2) Inhibitors In Patients With End-Stage Renal Disease (Esrd) And Dialysis, Daiwik Munjwani, Amin Yehya

Cardiovascular Research Symposium

Introduction: Sodium-glucose cotransporter 2 (SGLT2) inhibitors have demonstrated cardioprotective and renoprotective benefits in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD). However, the effects of these agents in patients with end-stage renal disease (ESRD) or on dialysis remain underexplored, as previous clinical trials often excluded this population. With the recent removal of ESRD as a contraindication by the U.S. Food and Drug Administration, understanding the cardiovascular risks of SGLT2 inhibitors in this group is imperative. This study aimed to assess the incidence of new onset heart failure (HF), including HF with reduced ejection fraction (HFrEF) and …

"Lost To Follow Up:" A Case Of An Adult Congenital Heart Defect Patient Who Faced Morbidity In Adulthood After Lacking Transitional Care Following Medical Intervention In Childhood, Mackenzie Kelley, Ashish Saini

Cardiovascular Research Symposium

CASE PRESENTATION: This patient is a 40 y.o. male with a BMI of 46.2 kg/m2 who presented to the ED with fluid overload, shortness of breath, and orthopnea. The patient was tachycardic and physical exam revealed anasarca and ascites. The patient reported chronic lower extremity and scrotal edema so severe that he had been unable to walk and was mainly homebound for the past two years. The patient’s past medical history was significant for hypertension, alcohol use disorder with history of withdrawal, and a cardiac murmur which the patient attributed to a “hole in the heart” for which he had …

Ice Guided Percutaneous Pseudoaneurysm Coil Embolization, Moudar Jano, Amir M. Hassani, Matthew R. Summers

Cardiovascular Research Symposium

Background: Pseudoaneurysm formation following cardiac procedures can be a significant complication due to the high risk of rupture. Traditionally managed through sternotomy and cardiac surgery, innovative percutaneous interventions have shown promise for high-risk patients. This case report highlights the successful application of ICE-guided percutaneous coil embolization for the treatment of aortic pseudoaneurysms, presenting a less invasive alternative for patients for whom traditional surgery poses significant risks.

Case Summary: A patient with a complex cardiovascular history, including aortic root and ascending aorta replacement and CABG x2, developed two pseudoaneurysms below the right coronary button and at the distal aortic graft-native aorta …

Association Of Physical Activity And Neighborhood Deprivation With Extracellular Vesicle Characteristics In African American Women With Obesity, Anca D. Dobrian, Yvonne Baumer, Tiffany Powell-Wiley, Lizzy Aquino-Peterson, Noel Miller

Cardiovascular Research Symposium

Association of Physical Activity and Neighborhood Deprivation with Extracellular Vesicle Characteristics in African American Women with Obesity

Association Of Glucagon-Like Peptide-1 Receptor Agonist Use With Cardiovascular Risk Reduction In Patients With Obstructive Sleep Apnea And Obesity: A Real-World Analysis, Jaeun Ahn, Jummin Song, Kyle Admire, Yu Chang, Kuan-Yu Chi, Joshua M. Sill

Cardiovascular Research Symposium

Introduction: Obstructive sleep apnea (OSA) is a well-established risk factor for cardiovascular disease. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have demonstrated promising potential in reducing cardiovascular risk and alleviating the severity of OSA. However, a significant knowledge gap remains regarding the impact of GLP-1RAs on cardiovascular events in OSA patients. This study utilizes large-scale global electronic healthcare record data to evaluate the associations of GLP-1RAs with improved cardiovascular outcomes.

Methods: We conducted a propensity score-matched retrospective cohort study using aggregate data from the TriNetX Global Network, which includes over 160 million patients from more than 120 healthcare organizations worldwide. The study …

Successful Transcatheter Edge-To-Edge Repair Of Mitral And Tricuspid Valves In A 77-Year-Old Patient With Structural Heart Disease, Omar Khan, Matthew Summers

Cardiovascular Research Symposium

This patient is a 77-year-old male with non-ischemic cardiomyopathy, severe tricuspid regurgitation, and moderate mitral regurgitation who underwent successful transcatheter edge-to-edge repair (TEER) of both valves. Post-procedure, the patient exhibited significant symptomatic improvement and reduced regurgitation severity, highlighting the feasibility of dual-valve TEER in high-risk patients.