Medicine and Health Sciences Commons^™

Hubungan Faktor Psikologis Dengan Atrium Fibrilasi: Suatu Tinjauan Kepustakaan, Arina Widya Murni, Annesa Fadella

Jurnal Penyakit Dalam Indonesia

Psychological factors influence the onset of cardiac rhythm and dysrhythmia disorders, including atrial fibrillation (AF), which is defined as uncoordinated atrial activation resulting in ineffective contractions. Psychological factors have a bidirectional relationship with AF, as AF symptoms can lead to a decline in mental health, which in turn negatively affects the clinical course. One explanation for how psychological stress impacts the heart and contributes to AF involves the autonomic nervous system and the hypothalamic-pituitary-adrenal (HPA) axis. Anxiety and depression are common comorbidities in AF. These conditions can be assessed using standardized instruments, such as the Hospital Anxiety and Depression Scale …

Ready For Takeoff? Exploring United States Health Care Providers’ Pretravel Consultation Priorities, Gaps, Barriers, And Opportunities, Katherine A. Reifler, Swati S. Sharma, Nicholas A. Bergren, Elizabeth D. Barnett, Lin H. Chen, Jeffery A. Goad, William B. Macleod, Laura Kogelman, Davidson H. Hamer

Pharmacy Faculty Articles and Research

Pretravel consultation by healthcare providers (HCPs) with travel medicine expertise can mitigate travel-related health risks. This analysis aimed to understand US-based HCPs' pretravel consultation educational gaps, priorities, barriers, and opportunities. An electronic survey was conducted May–June 2024, using a convenience sample of HCPs identified through the Med Learning Group and travel specialists from the International Society of Travel Medicine and American Society of Tropical Medicine and Hygiene. In total, 205 HCPs completed the survey, including physicians (50 %), nurse practitioners (19 %), nurses (12 %), pharmacists (11 %), physician associates (7 %). Most (66 %) provided pretravel consultations and only …

Quality Improvement Project Implementing Teamstepps 3.0: Impact On Perception Of Teamwork, Angela Allen

Doctor of Nursing Practice Projects

The clinical practice site is a rural health clinic that has experienced 28% staffing turnover in the last year, and opportunities for improvement in communication and teamwork were identified. The principal investigator (PI) used the Iowa Model Revised (IMR) as a theoretical framework and Lippitt’s change theory to promote change for the identified priority issue. TeamSTEPPS is an evidence-based program designed to improve communication and teamwork in healthcare teams with the goal of improving patient outcomes and safety. The quality improvement project utilized a quasi-experimental design with pre- and post-intervention surveys to answer the question: among staff at a rural …

Intentional Rounding In The Pediatric Population, Lauren Moccia, Madison Martin, Megan Mcmanus

Vizient/ AACN Nurse Residency Program™ EBP Projects

No abstract provided.

Administración Y Organización Deportiva. Conceptos Y Aplicaciones, Myriam Andrea Beltrán Benavides, Daniel Mejía Lizarazo

Ciencias del Deporte y la Educación Física

Las organizaciones deportivas en su administración requieren incluir aspectos de gestión que abarquen y aseguren un correcto funcionamiento, desarrollo y cumplimiento de sus objetivos; estos elementos son esenciales para la eficiencia, sostenibilidad y crecimiento. En un entorno deportivo cada vez más competitivo y profesionalizado, integrar prácticas administrativas no solo consolidan estructuras organizativas sólidas, sino que además contribuyen al desarrollo integral del deporte a nivel local, nacional e internacional, de tal manera que una adecuada administración promueve la transparencia, mejora la comunicación interna y externa y contribuye al fortalecimiento de la relación con los grupos de interés.

Quality Improvement Project Improve Staff Knowledge On Spravato For Treatment Resistant Depression, Cynthia Barraza Guerra

Doctor of Nursing Practice Projects

Treatment-resistant depression (TRD), defined as major depressive disorder unresponsive to at least two adequate antidepressant trials, is linked to higher morbidity, diminished quality of life, and increased healthcare utilization. Spravato (intranasal esketamine), approved by the U.S. Food and Drug Administration, provides a novel mechanism of action through N-methyl-D-aspartate (NMDA) receptor modulation but requires strict safety oversight due to risks including dissociation and hypertension. This Doctor of Nursing Practice (DNP) quality improvement (QI) project evaluated whether a targeted educational intervention improved staff knowledge and confidence in Spravato safety protocols. Guided by Lewin’s Change Theory, Bandura’s Social Learning Theory, and implemented with …

Quality Improvement Project High-Quality Simulation Training For High-Quality Nurse Educators, Cherrelle Hawkins

Doctor of Nursing Practice Projects

The Associate of Applied Science in Nursing (AASN) faculty use simulation as a teaching modality to assist nursing students in preparing for their clinical experiences by transitioning knowledge into practice. To successfully facilitate simulations, faculty must possess knowledge and competence in facilitating simulation sessions. Faculty at the practice site lacked these characteristics due to the nonexistence of a simulation training program. This quasi-experimental quality improvement project aimed to implement formal simulation training for faculty to influence self-perceived knowledge and competence in facilitation constructed by the Adult Learning Theory and the Awareness-Desire-Knowledge-Ability-Reinforcement (ADKAR) Change Model. The PI evaluated knowledge and competence …

Quality Improvement Project Impacting Provider Self-Efficacy And Use Of Cbt For Depression Treatment, Tony Orafunam

Doctor of Nursing Practice Projects

This Doctor of Nursing Practice (DNP) quality improvement project was conducted at a mid-sized outpatient psychiatric clinic in Hempstead, New York, focusing on strengthening providers’ self-efficacy in delivering Cognitive Behavioral Therapy (CBT) to young adults (aged 19–35) diagnosed with Major Depressive Disorder (MDD). Rather than targeting MDD directly, the initiative aimed to impact provider self-efficacy and skill in CBT to improve access to evidence-based treatment and reduce the need for external referrals. Employing Bandura’s Social Cognitive Theory and the ADKAR change model, the project used a quasi- experimental, one-group pre-test/post-test design. Six advanced practice providers participated in a structured, interactive …

Quality Improvement Project Providing Accessible Evidence-Based Education To Nurses Throughout A National Healthcare System, Bailey Wells

Doctor of Nursing Practice Projects

The pursuit of ongoing professional development and learning is crucial to ensure nurses remain well-informed about healthcare trends and have access to the most up-to-date evidence-based materials. This quality improvement project aimed to implement a monthly educational series for nursing personnel within the Veterans Health Administration (VHA) through expansion of the Veterans Administration (VA) – Extension for Community Healthcare Outcomes (ECHO) program. Using Bandura’s Self-Efficacy Theory of Motivation in Psychology, participants’ previous knowledge was linked to continued professional development. The plan, do, study, act (PDSA) framework provided structure for the project, with the awareness, desire, knowledge, ability, and reinforcement (ADKAR) …

Quality Improvement Project Unlocking Critical Thinking: The Use Of Guided Reflection In Nursing Education, Alissa Wheat

Doctor of Nursing Practice Projects

Nursing education is at a crossroads as the demand for practice-ready nurses increases in a rapidly evolving healthcare environment. Despite high licensure pass rates, graduates often demonstrate gaps in clinical judgment and critical thinking, key competencies for safe nursing practice. This project addressed the problem of limited structured strategies to develop these competencies among pre-licensure nursing students in a Houston-based nursing program. The purpose was to evaluate guided reflection, implemented as a competency-based education (CBE) tool, to determine its effect on faculty perceptions of supporting critical thinking and clinical judgment. A quasi-experimental, one-group pretest–posttest design was conducted with clinical faculty …

Hubungan Hiperurisemia Dengan Penurunan Lfg Pada Pasien Penyakit Ginjal Diabetes Di Rscm Jakarta, Rury Maharani Adna, Maruhum Bonar Hasiholan Marbun, Ikhwan Rinaldi, Em Yunir, Sukamto Koesnoe, Gurmeet Singh, Robert Sinto

Jurnal Penyakit Dalam Indonesia

Introduction. Elevated serum uric acid levels are associated with the progression of kidney disease in patients with type 2 diabetes mellitus (DM), through mechanisms involving endothelial dysfunction, oxidative stress, and chronic inflammation. Research in Indonesia on the relationship between uric acid levels and the decline of glomerular filtration rate (GFR) in diabetic patients remains limited. This study aimed to determine the association between serum uric acid (SUA) levels and decline in glomerular filtration rate among patients with diabetes mellitus diagnosed with diabetic kidney disease at Cipto Mangunkusumo Hospital, Jakarta, over a one-year period.

Methods. This retrospective cohort study …

Pengaruh Heart Rate Variability Terhadap Kesintasan Pasien Dengan Kanker: Laporan Kasus Berbasis Bukti, Kartika Anastasia Kosasih, Nida Raniah, Rudi Putranto, Wulyo Rajabto, Hamzah Shatri, Edward Faisal, Vinandya Irvianita Poespitasari

Jurnal Penyakit Dalam Indonesia

Depression, anxiety, and poor outcomes in cancer are possibly mediated by autonomic dysfunction. Autonomic disfunction found in cancer patients can cause increase in sympathetic tone and decrease in cardiac muscle vagal tone. Heart rate variability (HRV) is a non-invasive index for measuring vagal response and a potential stress response in autonomic dysfunction. In patients with cancer, high vagal tone measured by HRV is significantly correlated with increased overall survival. This evidence-based case report aims to investigate the role of HRV as a prognostic factor in cancer patients. Literature search was done by two authors on five databases: Pubmed, Cochrane Library, …

Hubungan Visceral Adiposity Index Dengan Neuropati Diabetik Perifer Pada Pasien Diabetes Melitus Tipe 2, Muhammad Arif Sanusi, Dian Anindita Lubis, Santi Syafril

Jurnal Penyakit Dalam Indonesia

Introduction. Type 2 diabetes mellitus (T2DM) is the leading metabolic disease in Indonesia. Diabetic peripheral neuropathy (DPN), a major complication of T2DM, was associated with insulin resistance and adipose dysfunction. Visceral adiposity index (VAI) is a tool to measure visceral fat as the indicator of adipose dysfunction and insulin sensitivity. The association between VAI and DPN has not been widely researched, especially in Indonesia. This study aims to assess the association between them.

Methods. This was a cross-sectional study conducted on adult patients (aged ≥18 years) with T2DM at H. Adam Malik General Hospital, Medan, from December 2024 …

Ebola Virus Vp35 Nnlns Motif Modulates Viral Rna Synthesis And Mib2-Mediated Signaling, Grace Uwase, Priya Luthra, Olivia A Vogel, Jyoti Batra, Bruno A La Rosa, Kathleen C F Sheehan, Oam Khatavkar, Jacqueline E Payton, Robert A Davey, Nevan J Krogan, Christopher F Basler, Daisy W Leung, Gaya K Amarasinghe

2020-Current year OA Pubs

Ebola virus (EBOV) is a nonsegmented, negative-sense virus (NNSV) with a single-stranded RNA genome. EBOV encodes for a limited number of proteins and thus depends on host factors to facilitate viral replication and pathogenesis. Of the virus-encoded proteins, multifunctional EBOV VP35 (eVP35) is necessary for host immune evasion and viral RNA synthesis. Previous proteomics studies identified an interaction between eVP35 and the host E3 ubiquitin ligase Mindbomb 2 (MIB2). Here, we show how an NNLNS (Asn-Asn-Leu-Asn-Ser) motif (residues 201 to 205) within eVP35 serves as a binding site for MIB2. This motif is critical for eVP35-dependent inhibition of MIB2-mediated interferon …

Long-Acting Recombinant Il-7 (Rhil-7-Hyfc) Enhances The Primary And Memory Neoantigen-Specific Immune Response To Breast Cancer Personalized Cancer Vaccines, Michael Chen, Thomas Kane, Ina Chen, Suangson Supabphol, Xiuli Zhang, Alexandra A Wolfarth, Donghoon Choi, Lijin Li, S Peter Goedegebuure, William E Gillanders

2020-Current year OA Pubs

No abstract provided.

Life-Moms: Effects Of Multicomponent Lifestyle Randomized Control Trial On Physical Activity During Pregnancy In Women With Overweight And Obesity, Hannah E Cabre, Debra Haire-Joshu, Alison G Cahill, Samuel Klein, Et Al.

2020-Current year OA Pubs

BACKGROUND: This report details the effect of LIFE-Mom's multicomponent lifestyle interventions on physical activity (PA) and inactivity time across pregnancy (2nd and 3rd trimesters) and their effect on gestational weight gain (GWG) and maternal/neonatal outcomes, a pre-specified secondary analysis.

METHODS: Pregnant people with BMI ≥ 25 kg/m

RESULTS: Although there were statistically significant differences in vigorous activity between the intervention and control group (p = .024), there were no clinically meaningful differences in PA. In the combined sample, moderate to vigorous PA (MVPA) significantly decreased across pregnancy (mean ± SD: 72.9 ± 29.1 min/day vs 63.9 ± 28.1 min/day; p …

Clinical Characteristics And Risk Factors Of Acute Pancreatitis In Paediatric Patients In Oman: An 11-Year Experience From A Tertiary Centre, Shurooq S. Al Shereiqi, Aisha Al Fudhaili, Dafalla Rahmatalla, Ravi Chandra, Sanjay Jaju, Ahmed Al Adawi, Adawiya Al Jamei, Yusriya Al Rawahi

Sultan Qaboos University Medical Journal

Objectives: The incidence of acute pancreatitis (AP) in the paediatric population has increased over the past two decades, with an estimated annual rate of 0.78 per 100,000 children. This study aimed to describe the risk factors and characteristics of AP in Omani children. Methods: A retrospective cohort study was conducted, including all children <14 years who were admitted and treated with AP at Sultan Qaboos University Hospital in Muscat, Oman, from January 2010 to December 2020. Case presentations, aetiology, management, and outcomes were reviewed. Results: During the 11-year study period, 55 cases were identified (male: female, 1.2:1). The most frequently reported risk factors were toxic/metabolic (49.1%). Abdominal pain was the predominant symptom (76.4%). Conservative treatment was administered in 74.5% of cases, while the remaining patients required surgery or endoscopic retrograde cholangiopancreatography. …

Documentation And Referral Of Social Determinants Of Health In New Mexico’S Emergency Departments: International Classification Of Disease, Tenth Revision, Clinical Modification, “Z Codes” (Z55-Z65), Samuel L. Swift, Maya Stefanovic, Roselyn Thalathara

Population Health Research and Scholarship

No abstract provided.

Quality Improvement Project De-Escalation Techniques Applied In The Classroom: A Faculty Onboarding Quality Improvement Initiative, Jennifer Lanza

Doctor of Nursing Practice Projects

The nursing shortage persists, and the lack of trained nurse educators exacerbates the issue. Adequate training of novice nurse educators transitioning from bedside to academia is essential for smooth role-transitioning, which impacts intent to stay; however, the content of the mentoring is undefined in literature. Using Bandura’s Social Cognitive theory as the theoretical framework and Havelock’s Process of Change theory, this Quality Improvement project aims to determine how providing de-escalation training adapted for the classroom impacts self-efficacy of novice nurse educators dealing with incivility in the classroom. The method includes incorporating the Plan-Do-Study-Act implementation framework for a quasi-experimental intervention which …

Conference Proceedings: Select Abstracts Presented At The 2025 Advocate Aurora Scientific Day, Advocate Aurora Scientific Day

Journal of Patient-Centered Research and Reviews

This abstract supplement includes findings presented through oral or poster presentations at the 51st annual Scientific Day event held on May 21, 2025. Scientific Day provides both an in-person and virtual forum for the sharing of research, quality improvement, and case studies conducted by Illinois- and Wisconsin-based faculty, fellows, residents, and other health professionals associated with Advocate Health.

Htlv-1 And Atll: Epidemiology, Oncogenesis, And Opportunities For Community-Informed Research In The United States, Adrian D. Altieri, Sean P. Reilly, Abu Mansalay, Alan Khoo, Nettie Johnson, Zafar K. Khan, Amy Leader, Pooja Jain, Pierluigi Porcu

Kimmel Cancer Center Faculty Papers

Human T-cell leukemia virus type 1 (HTLV-1), the first oncogenic human retrovirus, causes adult T-cell leukemia/lymphoma (ATLL), an aggressive neoplasm of mature CD4+ T-cells that is incurable in most patients and is associated with a median survival of less than 1 year. HTLV-1 also causes inflammatory disorders, including HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and uveitis. The estimated lifetime risks of ATLL and HAM/TSP in HTLV-1 carriers are 3-5% and 0.25-1.8%, respectively. Although there is uncertainty about other health effects of HTLV-1, a recent meta-analysis showed an association between HTLV-1 and cardiovascular, cerebrovascular, and metabolic diseases and a 57% increased risk …

Ketorolac Use Following Operative Clavicle Fracture Fixation Is Not Associated With Increased Nonunion Or Surgical Complications: A Propensity-Matched Analysis, Tuckerman Jones, Tej Joshi, Akhil Katakam, Daniella Ogilvie, Sefy Paulose, Balazs Galdi

Wills Eye Hospital Papers

OBJECTIVES: Nonsteroidal anti-inflammatory drugs (NSAIDs), including ketorolac, are commonly used for postoperative pain management. Concerns about their potential impact on bone healing have been raised. This study investigated the relationship between ketorolac use and postoperative complications following clavicle surgery, including nonunion rates.

METHODS: This retrospective cohort study used the TriNetX Research Database to identify patients who underwent surgical fixation of clavicle fractures between 2002 and 2022. Two propensity-matched cohorts were created: patients who received postoperative ketorolac and those who did not. Primary outcomes included nonunion diagnosis and revision surgery; secondary outcomes included opioid use, wound disruption, surgical site infection, and …

Charting Truth, Trust, And Transformers: A Critical Look At Ai Text Detection And Recommendations For Medical Journals, Hari Mudipalli, Mahtab Milburn, Souritya Saha, Jamie Fairclough

Journal of Patient-Centered Research and Reviews

This editorial provides an overview of large language models (LLMs), the risks associated with their use, and the challenges involved in using artificial intelligence (AI) to determine the extent to which LLMs have been used to write text, including articles for publication in medical journals. As narratives generated by LLMs become increasingly difficult to distinguish from human writing, concerns have emerged about their impact on scholarly communication, particularly in health and medicine. The medical community is becoming more aware of various tools that can detect AI-generated text; however, adopting these tools comes with unique challenges. The purpose of this article …

Perspectives On Communicating Information And Shared Decision-Making In Patients Undergoing Transtibial Amputation, Lina Walther Sjödin, Lasse J. Lapidus, Eva Torbjörnsson

Journal of Patient-Centered Research and Reviews

Purpose: Patients undergoing lower extremity amputation often desire to take an active part in decision-making. The primary aim of this study was to explore patients’ experiences of the care trajectory and information provided after a new care program was introduced. The secondary aim was to explore patients' perspectives of their involvement and participation in shared decision-making throughout the care process. The care program features new educational material, recommendations for the sagittal surgical technique, and information about a rigid removable dressing, early liner treatment, and a multidisciplinary team follow up three weeks after amputation.

Methods: Fifteen participants who underwent transtibial amputation …

Self-Management And Support Needs Of Patients Experiencing Persistent Symptoms Consistent With Hypothyroidism: A Qualitative Study, Marike De Reuver-Schuurman, Esther C. Bakker, Lilian Lechner, Liset Van Dijk

Journal of Patient-Centered Research and Reviews

Purpose: To gain insight into the self-management and support needs of patients experiencing persistent symptoms consistent with hypothyroidism, despite thyroid laboratory values within the normal range.

Methods: A qualitative study using the phenomenological approach was conducted. Semi-structured interviews including 19 patients diagnosed with persistent symptoms consistent with hypothyroidism, despite receiving adequate replacement therapy, were performed. Respondents were recruited using purposive sampling via Schildklier Organisatie Nederland (Dutch Thyroid Organization) (www.schildklier.nl). After transcription and coding, a thematic analysis was performed.

Results: All respondents reported that the persistent symptoms reduced their quality of life. The patients’ main focus was on finding the cause …

Understanding The Burden Of Myocardial Infarction And Patient Preferences For Treatment: A Real-World Study Assessing Patients’ Perspectives Via An Online Survey, M. Cecilia Bahit, Serge Korjian, Gerald Chi, Yazan Daaboul, Alberto Castro Molina, Ginger Jiang, Christiana Dangas, Mudit Tandon, Deepak L. Bhatt, Roxana Mehran, Harriette G.C. Van Spall, Paul Nara, Alka Shaunik, Charles Michael Gibson

Journal of Patient-Centered Research and Reviews

Purpose: Myocardial infarction (MI) remains to be associated with a high risk of recurrent cardiovascular events and disease burden. This study assessed patient perspectives on the burden of disease and treatment in the first year post-MI.

Methods: Data were collected via a self-administered online questionnaire posted on the Carenity patient platform in the United States (10/30/2022−12/30/2022). Only patients who had an MI in the prior year were eligible for inclusion.

Results: A total of 151 patients completed the survey. The majority were men (69%), median age was 50 years, and 38% had an MI within the previous 90 days. Overall, …

Whose Burden, Whose Benefit? Revisiting Ethical Trade-Offs In The Who Guidelines On Scaling Up Mass Azithromycin Administration, Maple Goh, A. M. Viens, Safura Abdool Karim, Aaron S. Kesselheim, Kevin Outterson

Faculty Scholarship

Author summary

• New evidence suggests that mass drug administration of azithromycin (MDAA) can significantly reduce childhood mortality in high-burden, low-resource settings, yet the World Health Organization’s (WHO) 2020 guidelines take a cautious approach due to concerns about antimicrobial resistance (AMR).
• While the WHO guidelines cite ethical principles, they insufficiently address key considerations, such as intergenerational justice, equitable burden sharing, and the structural determinants of health that shape infectious disease vulnerability.
• Global AMR policy often prioritizes conservation over access in ways that disproportionately burden low-income countries, despite high-income countries also bearing significant responsibility for the emergence and spread of AMR.
• A …

Design And Application Of A Tau Seed Amplification Assay For Screening Inhibitors Of Tau Seeding, Damian Gorski, Haley Evans, Tyler Allison, Carla Barria, Danielle Harrison, Victor Banerjee, Nicolas Mendez, Mohammad Shahnawaz, Sanne Kaalund, Jonas Folke, Susana Aznar, Paul Schultz, Fei Wang, Claudio Soto

Faculty, Staff and Student Publications

Background: Tau protein aggregates are a key pathological hallmark of Alzheimer's disease (AD) and are closely associated with cognitive decline and neurodegeneration. It is proposed that tau aggregates faithfully propagate throughout the brain by self-templating their disease-associated conformation onto natively-folded tau monomers, thereby inducing their aggregation and incorporation into growing fibrils. As such, the inhibition or modulation of tau seeding and aggregation represents a viable therapeutic strategy for AD and other tauopathies.

Methods: We have recently developed seed amplification assays (SAA) for the detection and amplification of small quantities of misfolded protein aggregates in various neurodegenerative diseases. In this article, …

Ready Or Not? An Autoethnography Of A Midwife’S Preparedness And Readiness Journey, Kristen Graham

The Qualitative Report

This emotive autoethnography explores my experiences working as an Australian midwife in low- and middle-income countries, which led to a Doctor of Philosophy journey exploring primary care midwives' preparedness and readiness in rural and remote communities in this context. I use the midwifery tradition of storytelling to explore personal experiences of preparedness and readiness as a way towards researcher reflexivity, understanding and meaning. Emerging themes of preparation for practice, resource limitations, heartache, and emotional resilience offer insights to inform midwifery education, research, and practice.

Improving Data-Driven Gated (Ddg) Pet And Ct Registration In Thoracic Lesions: A Comparison Of Ai Registration And Ddg Ct, Tinsu Pan, M Allan Thomas, Yang Lu, Dershan Luo

Faculty, Staff and Student Publications

Purpose: Misregistration between CT and PET can result in mis-localization and inaccurate quantification of the tracer uptake in PET. Data-driven gated (DDG) CT can correct registration and quantification but requires a radiation dose of 1.3 mSv and 1 min of acquisition time. AI registration (AIR) does not require an additional CT and has been validated to improve registration and reduce the 'banana' misregistration artifacts around the diaphragm. We aimed to compare a validated AIR and DDG CT in registration and quantification of avid thoracic lesions misregistered in DDG PET scans.

Methods: Thirty PET/CT patient data (23 with 18F-FDG, 4 with …