Medicine and Health Sciences Commons^™

The Effect Of Glp-1 Receptor Agonists On Reoperation Following Anterior Cervical Discectomy And Fusion, Nicholas C. Bank, Daniel Whittingslow, Sam Duggan, Joshua L. Morningstar, Douglas S. Weinberg

Student Papers, Posters & Projects

BACKGROUND: Pseudarthrosis remains a significant complication of ACDF, contributing to patient morbidity and increased healthcare costs. Glucagon-like peptide-1 receptor agonists (GLP-1RA), widely prescribed for diabetes and obesity, have been shown to reduced odds of pseudoarthrosis after ACDF. However, it remains unclear whether these reductions meaningfully translate to reduced odds of subsequent cervical surgery.

METHODS: The TriNetX United States Collaborative Network was queried for patients who underwent single- or multi-level ACDF between 2013-2023. Patients with perioperative GLP-1RA use and propensity-score-matched controls without GLP-1RA use were compared for subsequent rates of pseudoarthrosis and cervical reoperation at 6-, 12-, and 24-month intervals. Odds …

The Next Drug Epidemic Is Legal: The Nation's Kratom Problem Is More Complicated—And More Harmful—Than It Seems, Elizabeth Walsh

Capstones

This two-part health and science investigative piece reports how kratom and its offshoots have quietly fueled a lucrative and legal addiction epidemic for the last decade. While kratom’s derivative alkaloid 7-hyrdoxymitragynine made headlines this year and as the DEA is poised to ban the strong derivative, “natural” kratom and other kratom-derived products will remain. This piece tracks the history of the 'gas‑station opioid' crisis in the U.S. over ten years: what was thought to be an innocuous southeast Asian supplement has become multi-billion dollar industry built on gray‑area laws, marketed falsehoods, and regulatory loophooles.

Part 1: The ‘Gas Station Opioid’ …

Nyc Falls Behind In Climate Resources For Pregnant And Postpartum Moms, Jada Simon

Capstones

The U.S. still holds the highest maternal mortality rate among high-income nations around the world. While national rates have since seen a slight decrease, Black mothers still see high maternal death rates in comparison to white mothers, showing that racial disparities in maternal death rates are still apparent. In NYC, the reason for these disparities are not just unequal access to quality healthcare, but also the poor living conditions of neighborhoods in the city that are made up mainly of minoritized groups. So far, it has gone unconsidered that that the maternal mortality and climate crises are happening concurrently. This …

Two Major Ontario Hospital Labs Bought Research Dogs From U.S. Breeder With Troubled Pastdogs Bred For Scientific And Medical Testing Suffer Abuse As The Scientific Industry Increasingly Turns To Alternatives For Research., Allison Hunter, Mary Beech, Sami Marshak, Kate Morano

Capstones

The purpose-bred dog breeding industry for research is little known. Each year, thousands of dogs are bred for scientific and medical testing, supplied to research facilities by a handful of major commercial breeders. But gaps in enforcement and regulation have allowed abuses to persist, even as the industry increasingly turns to alternatives to animal testing. Animal rights advocates have been decrying the treatment of these dogs. A federal Inspector General report found lax oversight of the industry, raising further concerns about how dogs are treated. This story was reported in collaboration with the Investigative Journalism Bureau, based in Toronto, and …

Beyond Precision: Ambiomic Survivorship In Childhood And Aya Cancer., Juan Antonio Ortega-García, Omar Shakeel, Nicole Wood, Antonio Pérez-Martínez, Jose Luís Fuster-Soler, Mark D. Miller

Manuscripts, Articles, Book Chapters and Other Papers

Background: Survival among children and adolescents and young adults (AYA) with cancer has improved substantially over recent decades; however, dominant survivorship models remain reactive-activated post-treatment and anchored to static exposure- and organ-based screening. This design underuses the anticipatory window at diagnosis and overlooks environmental and social determinants that modulate outcomes across the life course. Methods: We narratively reviewed international frameworks including the Children's Oncology Group (COG), the International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG), the Pan-European Network for Care of Survivors after Childhood and Adolescent Cancer (PanCare) and the National Comprehensive Cancer Network (NCCN), and synthesized evidence …

(Un)Intended Consequences Of Race In Medicine: The Ethics Of Race-Based Medical Practice And The Perpetuation Of Structural Racism, Allegra Merriweather

Electronic Theses and Dissertations

This dissertation proposes that race-based medicine acts as a form of structural racism that is ethically indefensible. While it may be claimed to be a neutral diagnostic tool, the medical use of race as a biological proxy only further enforces the very hierarchies it purports to remediate, reinscribing inequity from conception to death. Building off Jacques Ellul’s work on Technique, we interpret race-based medicine as a self-perpetuating system that values procedural expediency over moral accountability. In nine chapters, the analysis follows the ways this technique is manifested in genetics and assisted reproduction, where commodified racial selection preserves social hierarchies; in …

Daily Intake Of A Lycopene-Rich Juice Is Associated With Reductions In Inflammatory Markers But Not Increases In Skin Carotenoids In A Pilot Study Among Participants With Obesity, Stephanie B Jilcott Pitts, Qiang Wu, Melissa N Laska, Elizabeth Gates, Megumi H Seese, Katelyn E Senkus, Santiago Carrero Longlax, Alexandra Portillo-Varela, Andrew R Dinardo, Nancy E Moran

Faculty, Staff and Students Publications

Background

Obesity is associated with systemic inflammation, increasing chronic disease risk. Carotenoids possess anti-inflammatory properties, yet the short-term impact of carotenoid-rich juice intake on inflammation in individuals with obesity remains unclear. Therefore, the purpose of this paper was to examine: (1) participant adherence to a 3-week lycopene-rich juice intervention; (2) variance and effect sizes of responses to the dietary intervention; (3) changes in skin and plasma carotenoids, and inflammatory markers among adults with obesity.

Methods

Twenty-five participants with body mass index (BMI) > 30 kg/m2 were recruited and completed the study. Participants drank 4 ounces (118.3 mL) of study-provided tomato juice, …

A Systematic Characterization Of Fibroblast Subtypes And Heterogeneity, Xiuli Zhu, Hongen Kang, Zhongming Zhao, Peilin Jia

Faculty, Staff and Student Publications

Fibroblasts are essential components in development, disease, and treatment response, yet their diversity and function remain incompletely understood. Here, we constructed a comprehensive fibroblast landscape by integrating large-scale single-cell and single-nucleus RNA sequencing datasets spanning 60 major human organs and tissues across various developmental stages and biological conditions. We identified 16 fibroblast subtypes and systematically characterized their tissue specificities, transcriptional heterogeneity, and cell states. Further analyses revealed distinct fibroblast subtypes associated with pluripotency and senescence across tissues. Leveraging the well-defined fibroblast atlas, we demonstrated that different fibroblast subtypes were associated with various complex traits such as anthropometric and immune diseases. …

Evaluating The Accuracy Of Point Of Care Testing Compared To Standard Laboratory Testing Among Inborn Infants In The Neonatal Intensive Care Unit, Isha Parikh, Sepideh Saroukhani, Matthew Rysavy, Brian Chang, Mar Romero-Lopez, Lindsay F Holzapfel

Faculty, Staff and Student Publications

Objective: Point-of-care (POC) testing offers expedited results with lower blood volume requirements than central laboratory (CL) tests, particularly for low-birth-weight infants.

Methods: A retrospective cohort included 118 patients with paired POC and CL tests within one hour in the first 14 postnatal days. Differences and agreement were assessed using linear mixed-effect models that account for within and between-subject variations.

Results: Compared to CL, POC testing underestimated sodium (6.0 mEq/L), potassium (0.1 mEq/L), chloride (5.1 mEq/L), and glucose (2.3 mg/dL), and overestimated hemoglobin (0.08 g/dL) and hematocrit (0.8%). Differences (CL- POC) varied by postnatal age and sample type, with larger differences …

Single-Nucleus Multiomics Reveals The Disrupted Regulatory Programs In Three Brain Regions Of Sporadic Early-Onset Alzheimer’S Disease, Andi Liu, Citu Citu, Nitesh Enduru, Xian Chen, Chia-Hao Tung, Tirthankar Sinha, Sofia E Sepulveda, Astrid M Manuel, Damian Gorski, Brisa S Fernandes, Meifang Yu, Paul E Schulz, Lukas M Simon, Claudio Soto, Zhongming Zhao

Faculty, Staff and Student Publications

Sporadic early-onset Alzheimer’s disease (sEOAD) represents a substantial but less-studied subtype of Alzheimer’s disease (AD). Here, we generated a single-nucleus multiome atlas derived from the postmortem prefrontal cortex, entorhinal cortex, and hippocampus of nine individuals with or without sEOAD. Comprehensive analyses were conducted to delineate cell type–specific transcriptomic changes and linked candidate cis-regulatory elements (cCREs) across brain regions. We prioritized eight conservative transcription factors in glial cells in multiple brain regions, including RFX4 in astrocytes and IKZF1 in microglia, which are implicated in regulating sEOAD-associated genes. Moreover, we identified the top 25 altered intercellular signaling between glial cells …

A Comparison Of Tenecteplase To Alteplase For Treatment Of Acute Ischemic Stroke Using Epic Cosmos Database, Marco Gonzalez Castellon

Theses & Dissertations

Ischemic stroke is highly prevalent and an important cause of morbidity, mortality, and long-term disability in the in the United States. The incidence and prevalence of stroke is expected to increase in the next few years due to several factors including aging of the U. S. population, improved treatment, and socioeconomic factors. In 1996, the FDA approved rtPA for the treatment of ischemic stroke patients. Patients had a greater likelihood of recovering successfully. However, rtPA has significant limitations, such as an elevated risk of intracranial hemorrhage, administration difficulties, and limited effectiveness. In March 2025, the FDA approved the use of …

Posterior Anatomic Limit For Mandibular Molar Distalization In Subjects With Different Growth Patterns, Genders, And Growth Status, Rehana Bashir

Theses & Dissertations

The objective of this study is to identify the anatomical limits for mandibular molar distalization, a technique frequently employed in orthodontics to address various malocclusions. Mandibular molar distalization plays a critical role in the management of crowding, and correction of the molar relationship.

It is imperative to assess the posterior anatomical space (PAS) in the mandibular retromolar area prior to distalization or uprighting the mandibular molars to avoid periodontal issues (dehiscence, orthodontically induced root resorption, and tooth mobility) and achieve successful treatment outcomes.

A clinical question that, however, isn't well understood is whether the amount of mandibular molar distalization is …

Assessment Of Polymeric Chloroquine Formulations For Targeted Therapy Of Ulcerative Colitis And Metastatic Colorectal Cancer, Neha Kumari

Theses & Dissertations

Effective targeted drug delivery is a critical unmet need in the management of both ulcerative colitis and metastatic colorectal cancer, where conventional systemic therapies may be hindered by suboptimal efficacy and significant side effects. This thesis explores the development and preclinical assessment of polymeric chloroquine (PCQ)-based nanotherapeutics, leveraging stimuli-responsive designs for disease-specific delivery and action.

For ulcerative colitis, a reactive oxygen species (ROS)-responsive nanogel system was engineered to release PCQ, a macromolecular derivative of hydroxychloroquine, specifically in the inflamed areas within the colon. Nanogels with well-defined size and positive surface charge were synthesized via reversible fragmentation chain transfer (RAFT) polymerization …

Development And Characterization Of Non-Viral Delivery Systems For Pulmonary Delivery Of Nucleic Acid Therapeutics, Kasturi Siddhanta

Theses & Dissertations

The development of non-viral delivery systems for pulmonary delivery of nucleic acid therapeutics is driven by the need for safer and more accessible approaches to treat lung diseases, while avoiding the systemic side effects and immune responses associated with viral vectors. Such systems encompass both non-invasive inhalation-based platforms, and systemically administered platforms designed to achieve localized lung delivery. These strategies aim to enable high drug concentrations at the site of action, rapid onset of therapeutic effect, and greater therapeutic efficacy than existing treatments. Designing effective pulmonary delivery systems requires precise optimization of particle properties—including size, morphology, surface characteristics, cell-specific targeting, …

Development Of Self-Assembled Polymeric Polyplexes For Microrna Delivery: Toward Treatment Of Alcohol-Associated Liver Disease, Marjina Akter Kalpana

Theses & Dissertations

Self-assembled polymeric polyplexes have the potential to serve as an RNA interference (RNAi) delivery platform for the combined inhibition of CXCR4 and miR-155 in the treatment of alcohol-associated liver disease (AALD). A central challenge in RNA delivery is balancing the extracellular stability of polyplexes, cellular uptake, and intracellular release of RNA cargo. We developed polymeric polyplexes using the CXCR4-antagonist polymer PAMD, designed to target CXCR4 on activated hepatic stellate cells (HSCs) and deliver therapeutic miRNA to activated Kupffer cells (KCs) in fibrotic liver. We improved the polyplexes by cholesterol modification of PAMD and by PEGylation of PAMD-Ch. The cholesterol modification …

Exposures, Protections, And Barriers: Advancing Understanding Of Agricultural Worker Health, Alexandra A. Farfalla

Theses & Dissertations

Farming is a hazardous occupation. Exposures are multifactorial, variable, and shaped by overlapping tasks, environments, and social contexts. This dissertation aimed to illustrate the complexity of agricultural exposures and the barriers to protective practices through three complementary studies.

The first study examined co-exposures to solvents and noise as risk factors for hearing loss (HL) among 7,495 farmers and ranchers in a 7-state region. Results indicated nearly 60% of co-exposed participants reported hearing loss, with an adjusted odds ratio nearly six-fold (OR=6.03, [4.67-7.78]) for moderate/severe HL. This work highlights the importance of recognizing chemical exposures as a modality in HL in …

Comparison Of Cervical Spine Injury Clinical Prediction Rules For Children After Blunt Trauma, Lois K. Lee, Fahd A. Ahmad, Lorin R. Brown, Monica Harding, Lawrence Cook, Kathleen Adelgais, Rebecca K. Burger, Alexander Rogers, Leah Tzimenatos, Lauren C. Riney, Daniel Rubalcava, Caleb E. Ward, Kenneth Yen, Julie C. Leonard

2020-Current year OA Pubs

No abstract provided.

Baseline Exposure-Response Assessment Of Metals From Dried Blood Spots And Personal Household Air Pollution Concentrations Among Pregnant Women In Rwanda: Household Air Pollution Intervention Network Trial, Adolphe Ndikubwimana, Lisa De Las Fuentes, Victor G Dávila-Román, Et Al.

2020-Current year OA Pubs

BACKGROUND: Exposure to metals from the combustion of biomass via inhalation may result in negative health outcomes affecting a variety of organs and systems. Pregnant women cooking with biomass fuels may be exposed to metals, such as lead (Pb) and cadmium (Cd), and have unique risks for adverse health effects with potential impacts on the growing fetus. We assessed the associations between household air pollution and metals detected in dried blood spots from pregnant women at baseline in Rwanda.

METHODS: We analyzed data from 781 pregnant women aged 18-35 years who resided in rural households using biomass fuel and who …

Abc Pharmaceutical Company Change Model: Implementing J.P. Kotter's 8-Step And Adkar Change Models For Ethical Alignment, Shelbi B. Chandler, Amalfi Gayosso, Alison Lawton, Ali Holness-Roland

The Scholarship Without Borders Journal

In this paper, we use the pseudonym ABC Pharmaceuticals (ABC) to refer to the company under examination, GlaxoSmithKline (GSK). ABC Pharmaceutical (ABC) must assess, adapt, and change to ensure regulatory compliance, maintain and attract employees, and remain competitive. ABC has a history of erroneous practices and is at risk internally with employees, and externally with regulators and the public sectors. The authors applied J.P. Kotter’s (1996) 8-step and the ADKAR (Hiatt, 2006) models for change management. J.P. Kotter’s top-down model addresses leadership’s role in creating a compelling vision aligned with its actions, and the ADKAR bottom-up model assesses employees’ readiness …

Personal Health Advice In The World Of Artificial Intelligence: An Assessment Of Responses From Chatgpt For Three Common Health Conditions In The Southern United States, Marion W. Evans Jr, Julie Harrison Swartz, Harrison Ndetan, Damian Francis, John Moore, Mary Kozub, Ernie Kaninjing, Jennifer Jones-Locklear, Debbie Greene, Josie Doss

Journal of Public Health in the Deep South

Background: Artificial intelligence (AI) applications within the health sciences including education and healthcare practice are now common. Patients are likely to apply AI to better understand their health status or to learn what they can do to improve their health.

Purpose: The purpose of this study was to evaluate outputs from ChatGPT for three common health conditions seen in the southern United States as to whether it would include medically biased care or lifestyle related advice, legitimate sources of information and to assess reading levels generated.

Methods: Health care professionals rated outputs in 4 areas and interrater …

Using Electronic Medical Records To Estimate The Prevalence Of Pediatric Obesity In Mississippi, Brian D. Christman, Abigail Gamble, Sonia Jain, Kalon Kl Ho, Lei Zhang, William B. Hillegass

Journal of Public Health in the Deep South

Background: Pediatric obesity is a major public health concern in Mississippi. However, existing surveillance systems, including the Youth Risk Behavioral Surveillance System, National Survey of Children's Health, and Child and Youth Prevalence of Obesity Survey, are limited by self-reported data, restricted age ranges, and incomplete subgroup coverage.

Purpose: This study evaluates the plausibility of using electronic medical records to improve population-level surveillance of pediatric obesity in Mississippi while addressing issues of data completeness, bias, and representativeness.

Methods: Electronic medical records from 40,215 patients aged 2–19 years who received care at the University of Mississippi Medical Center (2013–2022) were analyzed via …

Assessing Education And Training Of Developmental Screening Tools Among Residents In A Southern Academic Medical Center, Paige Seabrook, Dustin E. Sarver, Susan Buttross

Journal of Public Health in the Deep South

Background: Developmental disabilities are highly common. Early identification of developmental disabilities is critical, but many practitioners, including those in Southern U.S. states like Mississippi, do not utilize developmental screening tools.

Purpose: We aimed to identify modifiable targets within resident training experiences and their correlates using a quality improvement approach to serve as a baseline for intervention efforts.

Methods: Medical residents (N = 57) in pediatrics (n = 26), combined medicine-pediatrics (n = 12), and family medicine (n = 19) completed a survey assessing training, attitudes, practices, and perceived barriers regarding using screening tools. Perceived barriers were …

Enhancing Public Health Strategies: Addressing The Rsv Burden In Alabama Through Clinical Treatment, Community Prevention, And Surveillance Approaches, Martha K. Findley Roper, Jennifer S. Dawson

Journal of Public Health in the Deep South

Introduction: Respiratory Syncytial Virus (RSV) is a highly contagious pathogen driving morbidity, hospitalizations, and economic burden. This review uses the epidemiological triad and National Wastewater Surveillance System data to assess transmission, viral load spikes in Alabama, and strategies for treatment and prevention.

Methods: A review of literature on supportive care, vaccination, monoclonal antibodies, and emerging nanomedicine was reviewed to evaluate strategies for reducing viral burden and complications.

Results: Trends from December 2024–January 2025 were assessed with National Wastewater Surveillance System data. Primary prevention includes immunization, hygiene, air quality maintenance, and early diagnostics. Tertiary care addresses complications such as secondary …

Risk For Infant Mortality Among Childbearing Women In Alabama, Michael Rutalira Koko

Journal of Public Health in the Deep South

Background: Infant mortality is an important indicator of the health of a population. From 2016 to 2020, the infant mortality rate in Alabama significantly decreased. However, disparities remain among different groups. The objective of this analysis is to evaluate risk factors and disparities of infant mortality for the past five years.

Methods: We used the Alabama Center for Health Statistics database, a population-based state vital records registry. We included 290,832 births to women aged 15 to 44 years linked to 1,575 infant deaths from 2016 to 2020. We excluded births at less than 20 weeks of gestation and weighing 500 …

Trends In Drug Overdose Deaths In Alabama, 2010-2020, Michael Rutalira Koko, Raphu Wakumeki

Journal of Public Health in the Deep South

Background: Drug overdose deaths are the leading cause of injury-related death in the United States. Over the past two decades, drug overdose deaths have dramatically increased in the United States, and the rise in the number of drug overdose deaths is mostly due to opioids. This descriptive study aimed to examine trends in drug overdose deaths according to age, sex, and race/ethnicity from 2010 to 2020 in Alabama.

Methods: We used data from the National Vital Statistics System (NVSS) and the U.S. Census Bureau to calculate age-adjusted mortality rates for specific age groups, gender, and race/ethnicity. We used SAS Version …

Collaborative Healthcare: Advancing Interprofessional Practice & Education, Volume 16, Number 1, Fall 2025/Winter 2026

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

In this Issue:

• From the Editors
• Spotlight on an Interprofessional Clinical Team
• Meet an IPE/IPCP Faculty Champion
• Meet an IPE/IPCP Student Champion
• A Journey Through Interprofessional Education (IPE) from Health Mentors to Palliative Care

Understanding The Relationship Of Culture And Language With Hiv, Cora Coletti

Student Scholar Symposium

HIV impacts 39.9 million people worldwide. Many people with HIV are the victims of stigmatizing language used by physicians, family members, and community members. In 2015 the Centers for Disease Control and the American Medical Association added language guidelines to prevent additional stigma in medical and scientific literature. Analyzing research from Baltimore, Nigeria, and Rwanda creates a global view of the impacts of language and culture on public health materials presented in communities where HIV is prevalent. Researching the perspectives of women, mothers, and physicians provides a diverse range of experiences people with HIV have gone through. Synthesizing the current …

Exploring Therapeutic Frontiers: The Beep Regimen In Breast And Brain Metastases, Destiny Carroll

Student Scholar Symposium

No abstract provided.

3d Modeling Of Brain Removal With Cranial Nerve Preservation, Lauren Blank, Sophia Cox, Avery Preston

Student Scholar Symposium

3D Modeling of Brain Removal with Cranial Nerve Preservation Abstract: Visual- spatial skills are essential in learning anatomy as they allow students to mentally visualize and manipulate the three-dimensional structure of the human body. Traditional dissectors like Grant’s Dissector typically provide only 2D images to guide brain removal. These manuals often do not include the occipital wedge approach, which favors cranial nerve preservation during brain dissection. A 3D model that assists students in learning a non-traditional dissection approach through manipulating a brain model will help improve mental rotation skills, especially benefiting those with weaker spatial abilities. In collaboration with Lipscomb …

Examining The Influence Of Mapped Bloom's Taxonomy Items On The Student Pharmacist Experience, Annaston Young

Student Scholar Symposium

Objective: To evaluate the impact of transparent Bloom’s Taxonomy (BT) item mapping on the student experience.

Methods: First-year student pharmacists were oriented to BT twice during their first semester. Using a quasi-experimental research design, a point-of-care testing (POCT) active learning exercise and related low-stakes assessment were identified for the intervention. Following the active learning, a five-question “exit ticket” on Google Forms was randomly distributed based on QR codes: Group 1 (n=20) had no BT item mapping and Group 2 (n=20) had BT labels for each item. Performance, confidence, and experience evaluation were captured on each exit ticket. Descriptive statistics were …