Medicine and Health Sciences Commons^™

Comparison Of Cisgender And Transgender Individuals’ Aerobic Fitness And Associated Parameters, L Vazquez, A Mohan, Y Kim, J Ekhtman, D Oberlin

International Journal of Exercise Science: Conference Proceedings

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Lower Limb Muscle Morphology In Individuals With Coronary Artery Disease: A Cadaveric Pilot Study, D Violi Dpt, Cscs, J Relkin Spt

International Journal of Exercise Science: Conference Proceedings

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Acute Betalain-Rich Concentrate Supplementation Does Not Improve Repeated Sprint Performance Or Recovery: A Pilot Study, S Vitti, M Smith, K Sulaimani, A Ward, P Huang, A Ramakrishan

International Journal of Exercise Science: Conference Proceedings

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Influences Of Methodology On Nerve Conduction Studies: Does Probe Pressure Influence M-Wave Variability?, S Washington, J Shields, A Barrera-Curiel, A Krahn, J Hernandez-Sarabia, G Hester, R Maclennan, C Mackey, C Smith, M Luera, J Defreitas

International Journal of Exercise Science: Conference Proceedings

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Effect Of Mouthpiece Style On Vo2 Performance, H Webber, R Emmons Facsm

International Journal of Exercise Science: Conference Proceedings

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Effects Of Acute Refueling On Anaerobic Power Test Performance During Pre-Season Soccer Training, D Williams, D Ebert, N Braun, J Nelligan, W Braun Facsm

International Journal of Exercise Science: Conference Proceedings

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Femoral Oscillatory Shear Patterns And Vascular Structure In Women Who Use Oral Contraceptives, P Williams, J Deblois, P Pagan Lassalle, S Ranadive, K Heffernan

International Journal of Exercise Science: Conference Proceedings

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Effect Of Weighted Vest Exercise On Lower Limb Blood Flow And Postural Sway, Z Wu, J Greenberg, K Heffernan Phd

International Journal of Exercise Science: Conference Proceedings

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Males Exhibit Higher Arterial Stiffness But Similar Augmentation Index And Microvascular Reactivity Compared With Females, O Zakrewski, W Parker, R Landers-Ramos

International Journal of Exercise Science: Conference Proceedings

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Dual Task Performance During Treadmill-Based Perturbation Trials In Young Adults, A Zhang, R Michaels, T Lalta, Y Moon

International Journal of Exercise Science: Conference Proceedings

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Effects Of Mindfulness On Heart Rate Variability And Pain Response During Cold Pressor Test, J Zimmerman, C Dulaney, M Akkad, J Heiland

International Journal of Exercise Science: Conference Proceedings

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Impact Of Blood Flow Restriction Cuff Design On Upper Body Exercise, S Zupnik, N Rolnick, V De Queiros, B Fedorko, S Watson, C Ruffhead, L Kuriawa, T Werner Facsm

International Journal of Exercise Science: Conference Proceedings

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The Effect Of A 50-Mile Ultra-Marathon Race On Vagal Modulation, M Baxter, Z Climenhaga, N Bearup, V Cave, K Dames, J Parks

International Journal of Exercise Science: Conference Proceedings

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Palm Cooling Between Sets Reduces Perceived Exertion Without Enhancing Performance During High-Load Deadlifts, J Aloi, R Hersey, H Presgrave, S Mcclain, N Flati, H Gerhart, P Prins, J Buxton

International Journal of Exercise Science: Conference Proceedings

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Agreement Between Self-Reported And Accelerometer Derived Sleep Durations, M Alidadi, T Barreira, K Harmon, Y Moon, M Armstrong

International Journal of Exercise Science: Conference Proceedings

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A Quantitative Analysis Of Postmarketing Safety Events Of Breakthrough Medicines, Richard Judson Davis

Walden Dissertations and Doctoral Studies

Adverse events to medicines pose a risk to the public health of patients. Breakthrough therapy medicines are designed to address unmet medical needs and are often approved on an expedited timeline; however they are also criticized for lacking an adequate understanding of their risk profile at the time of approval. This study examined the relationship between the number of concomitant medicines, as well as the approved therapeutic indication, and the outcomes of reported adverse events associated with medicines approved under the breakthrough therapy designation. The conceptual framework applied in this retrospective, cross-sectional, quantitative study is the process of pharmacovigilance, which …

Multimodal Reprogramming Of The Tumor Microenvironment By Mmr And Dual Checkpoint Blockade In Hepatocellular Carcinoma Models, Mulu Z. Tesfay, Aleksandra Cios, Khandoker Usran Ferdous, Randal S. Shelton, Bahaa Mustafa, Camila C. Simoes, Murat Gokden, Isabelle R. Miousse, Kimberly J. Krager, Marjan Boerma, Alicja Urbaniak, Anuradha Kunthur, Sri Obulareddy, Joshua M. Eichhorn, Steven R. Post, Jean Christopher Chamcheu, Omeed Moaven, Chiswili Y. Chabu, Dan G. Duda, Matteo Conti, Bruno Nardo, Rang Govindarajan, Martin E. Fernandez-Zapico, Lewis R. Roberts, Mitesh J. Borad, Martin J. Cannon, Alexei G. Basnakian, Bolni M. Nagalo

Faculty Publications

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, thus, there is an urgent need to develop more effective therapeutic options for this dismal condition. Tumor-infiltrating lymphocytes (TILs) are associated with improved response to immune checkpoint blockade in HCC, but their low abundance in most cases limits their therapeutic efficacy. Here, we demonstrate, in mice, that low-dose intratumoral immunovirotherapy with the trivalent measles, mumps, and rubella vaccine (MMR) induces superior tumor-growth delay and extended host survival compared to individually administered vaccines for measles, mumps, or rubella viruses. Further, our results show that MMR therapy synergizes with PD-1 and …

The Importance Of Treating Migraine Attacks Early - Even In Youth: A Real-World Argument For Neuromodulation, Mario F. P. Peres, Hsiangkuo Yuan, Cristina Tassorelli

Department of Jefferson Headache Center Papers and Presentations

No abstract provided.

Prevalence Of Sleep Disturbance And Associated Risk Factors In Degenerative Cervical Myelopathy, Salim Yakdan, Karan Joseph, Jingyi Zhang, Miguel A Ruiz-Cardozo, Aryan Pradhan, Alisha Dhallan, Faraz Arkam, Willliam Mualem, Garrison Bentz, Diogo P Moniz Garcia, Benjamin Plog, Alexander T Yahanda, Daniel Hafez, Wilson Z Ray, Camilo A Molina, Jacob K Greenberg

2020-Current year OA Pubs

Retrospective Case-Control.

Orsay Virus Variants Isolated From Wild Caenorhabditis Elegans Nematodes, France, Chika Fujii, Susan Vernon, Marie-Anne Félix, David Wang

2020-Current year OA Pubs

Four new variants of Orsay virus were identified from wild isolates of

A Plain Language Summary Publication Of Patients' Survival With Endometrial Cancer Treated With Dostarlimab Plus Carboplatin-Paclitaxel, Matthew A Powell, Carolyn Mccourt, Et Al.

2020-Current year OA Pubs

What is the purpose of this PLS-P? The purpose of this plain language summary of publication is to help you understand recent findings from Part 1 of the RUBY study (full name ENGOT-EN6/GOG3031/RUBY trial). • Researchers sometimes study new combinations of already approved individual treatments to see if the combinations work well together and if they are safe to prescribe to patients. • In Part 1 of the RUBY study, the combination of

Individuals’ Experiences Of Care Partner Involvement In Heart Disease Management: A Pilot Study, Elizabeth Richards

School of Nursing Faculty Publications

Introduction: Heart disease impacts both those diagnosed and their families, often due to lifestyle modifications that can alter family dynamics. While existing literature focuses on men and married individuals, understanding care partner involvement for both men and women independent of marital status is important, given gender disparities in heart disease experiences, caregiving roles, and widowhood rates. We explored differences in characteristics of men and women with heart disease, with and without a care partner. Additionally, we explored involvement of care partner beyond spousal relationships. We further examined gender differences in these experiences. Method: Cross-sectional Prolific survey pilot data of persons …

Beyond Racial Categorization In Sports Cardiology: A Systematic Review Of Cardiac Adaptations In Athletes, Douglas Corsi, Rafael Hernandez, Jasmine Yimeng Bao, Stephen Garrova, David Shipon

Division of Cardiology Faculty Papers

Background/Objectives: Race-based cardiac screening criteria in sports cardiology, including the “Black athlete’s heart” concept, assume biological distinctions that may not reflect physiological reality. This systematic review evaluates whether geographic ancestry provides more clinically relevant predictors of cardiac adaptation than racial categorization. Methods: PubMed was searched (January 2005–July 2025) for studies examining cardiac adaptations in athletes by ethnicity. Data extraction captured demographics, geographic origin, cardiac assessments, and outcomes. Narrative synthesis was employed due to methodological heterogeneity. Results: Forty-seven studies (n = 66,130) revealed substantial within-race heterogeneity. The “Black athlete repolarization variant” prevalence ranged from 1.8% (Brazilian) to 30% (Ghanaian) Black athletes. …

Educating Emergency Department Nursing Staff: Early Identification Of Sepsis, Cynthia A. Chaney

Walden Dissertations and Doctoral Studies

Sepsis remains a life-threatening health challenge, contributing to significant morbidity and mortality within healthcare systems. This Doctor of Nursing Practice (DNP) project aimed to address knowledge deficits among emergency room nurses regarding the early identification and management of sepsis, mainly through the implementation of the 3-hour sepsis bundle. The practice-focused question guiding this project was whether educating nurses on the 3-hour sepsis bundle would increase their knowledge. This project aimed to educate nurses on how to identify sepsis early and implement the sepsis 3-hour bundle in a timely manner, with the overall goal of improving nursing knowledge. The sources of …

Evaluating The Potential And Limitations Of Nanopore Adaptive Sampling For Targeted Transcriptome Sequencing, Nicole Debruyne, Feng Wang, Yang Xu, Lan Lin

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Long-read RNA sequencing is a powerful technology for transcriptomics, but low throughput and high cost pose challenges. Adaptive sampling, a feature of Oxford Nanopore Technologies, offers real-time enrichment by selectively ejecting non-target molecules. We evaluate adaptive sampling for human transcriptome analysis. Adaptive sampling modestly enriches target transcripts (1.3 × for cDNA sequencing, 1.9 × for direct RNA sequencing) while preserving gene expression and splicing profiles, but is significantly less effective than cDNA hybridization capture. Short read lengths and low sequencing quality limit performance. Adaptive sampling on direct RNA sequencing can boost target yield (~ 20%) within fixed run times, potentially …

Histologic Assessment In Ulcerative Colitis: A Survey Of Pathologists' Practices And Perspectives, Krithika D Shenoy, Jiannan Li, Adam L Booth, Xiuli Liu

2020-Current year OA Pubs

BACKGROUND: Histologic remission is increasingly recognized as an important endpoint in ulcerative colitis (UC) management. Consensus guidelines on adopting histologic scoring systems in clinical practice are lacking in the United States. This study aimed to assess the knowledge, attitudes, and practices of pathologists, primarily located in North America, regarding histologic evaluation in UC.

METHODS: This study surveyed a group of pathologists who have completed postdoctoral medical training with demonstrated interest and involvement in the field of gastrointestinal pathology to evaluate their knowledge, practices, and perspectives on histologic assessment using standardized scoring systems in clinical practice in UC patients. The survey …

Septic Arthritis And Abscess Of The Temporomandibular Joint, Frank Rizzuto, Abdul Khan, Jagan D. Gupta, Neel D. Gupta, Triet M. Do, Enrique Palacios

School of Medicine Faculty Publications

No abstract provided.

Transcriptomic Analysis Demonstrates Moderators Of Muscle Quality Are Altered In Age-Related Sarcopenic Obesity, Eleanor R. Schrems, Ana Regina Cabrera, Ronald G. Jones Iii, Francielly Morena, Kevin A. Murach, Nicholas P. Greene, Tyrone A. Washington

Health, Human Performance and Recreation Faculty Publications and Presentations

BackgroundSarcopenic obesity (SO) is the combined condition of sarcopenia and obesity, which commonly occurs in the older adult population. SO is associated with poor physical function, increased risk of musculoskeletal injury, and reduced quality of life and independence. Information on the molecular underpinnings of this condition is limited. The aim of this study was to provide a transcriptomic analysis characterizing SO induced by lifelong obesity and to provide a deeper understanding of the etiology of the condition.ResultsYoung (Y) (6 mo) and aged (A) (21-24 mo) mice were fed either normal chow (L) (12% kcal from fat) or high-fat (O) (60% …

Sti Testing And Diagnosis Rates Among Patients With Mpox In 2 Populous Us Cities, 2022, Shauna H Gunaratne, Karen J Vigil, Simian Huang, Nina Kumenda, Jacob Mclean, Clare Delaurentis, Delivette Castor, Jason Zucker

Faculty, Staff and Student Publications

Background: Mpox is recognized as a sexually transmitted infection, and the 2022 epidemic and 2024 resurgence of mpox cases through sexual transmission highlighted the need for sexually transmitted infection (STI) testing. Our objective was to observe rates of STI testing and STI diagnoses in patients with confirmed mpox in Houston, Texas and New York City, New York (NY).

Methods: This was a retrospective cohort study involving manual review of confirmed mpox cases at three large clinical centers in Houston, Texas and New York City, NY. Descriptive statistics were calculated for rates of STI testing and new diagnoses of syphilis, chlamydia …

The Role Of Traumatic Brain Injury On Intimate Partner Violence And Changes In Mental Health From Late Adolescence To Young Adulthood, Eric J Connolly, Elizabeth Baumler, Deborah M Little, Meghan L Royle, Anne C Wingert, Leila Wood, Jeff R Temple

Faculty, Staff and Student Publications

Purpose: Intimate partner violence (IPV) victimization and traumatic brain injury (TBI) are common correlates of mental health problems in adolescence. However, research has yet to investigate whether IPV victimization is related to developmental changes in mental health, as well as the contributing role that TBI may play in conditioning this association. We address this gap by analyzing longitudinal data with well-validated measures of mental health from an ethnically diverse sample of adolescents.

Methods: Prospective data from the Dating it Safe sample (n = 699) were used to measure IPV victimization, depression, post-traumatic stress, binge drinking, and TBI from 2015 to …