Medicine and Health Sciences Commons^™

Plasma Biomarkers In Neuropsychiatric Syndromes: A Narrative Review, Zahinoor Ismail, Dylan X Guan, Ganesh Babulal, James Bateman, Marc Cantillon, Byron Creese, Fabrizia D'Antonio, Corinne Fischer, Jennifer Gatchel, Chinedu Momoh

Brain and Mind Institute

Neuropsychiatric symptoms (NPS) are common features of neurodegenerative disease (NDD) but are relatively understudied compared to cognition, especially regarding biomarkers. Further, emerging evidence describes the utility of systematic assessment of NPS across the cognitive continuum, even in advance of dementia. In this narrative review, we discuss the role of plasma biomarkers in relation to NPS across the cognitive continuum of unimpaired, subjective cognitive decline, mild cognitive impairment, and dementia. While Alzheimer's disease is the primary focus, vascular, Lewy body, and frontotemporal dementia etiologies are also discussed. Literature searches included NPS and dementia-related search terms with additional literature identified based on …

Honoring Constellations, Prachi S. Gandhi

be Still

“Honoring Constellations” is a meditation on the quiet labor of attention in spaces shaped by caregiving, illness, and uncertainty. The poem was born from the emotional weight of witnessing how each patient, each moment, carries a constellation of stories that are often untold. In clinical spaces, time presses forward relentlessly, but I wanted to pause inside that pressure to explore what it means to hold space for lives at the threshold of change or loss. The poem aims to honor the meaning that exists even in apparent silence. Here, attention is not just presence; it’s a form of reverence.

Prevalence Of Local Ige Elevation And Its Effect On Intranasal Capsaicin Therapy In The Nonallergic Rhinitis Population, Kunal R Shetty, Salman Hasan, Christopher Bankston, Dylan Vance, Elaijah Islam, Gabriella Cruz, Faramarz Ashoori, David Z Allen, William C Yao, Martin J Citardi, Amber U Luong

The Brown Foundation: Institute of Molecular Medicine

No abstract provided.

Exploring Perception Of Coarticulatory Cues In Childhood Apraxia Of Speech And Residual Speech Sound Disorders: A Pilot Study, Molly Beiting, Navin Viswanathan, Nicole Caballero, Elaine Hitchcock, Tara Mcallister, Jonathan L. Preston

Department of Communication Sciences and Disorders Faculty Scholarship and Creative Works

Introduction: Children with childhood apraxia of speech (CAS) exhibit speech production deficits beyond segmental errors, including atypical coarticulation. Broadly, children with speech sound disorders (SSD) also exhibit weaknesses in speech perception, which may directly relate to specific production difficulties. This study examined differences in categorical perception among children with CAS, residual SSD affecting /ɹ/ (rSSD), and typical speech (TD). We hypothesized that children with CAS would demonstrate weaker performance on a task requiring perception of coarticulatory cues—a defining weakness in their speech production—but perform similarly to rSSD peers on a segmental task. Methods: This study was designed as an exploratory …

Botulinum Toxin In Stiff Person Syndrome: How Useful Is It In Helping Muscle Stiffness And Spasms?, Marinos Dalakas

Department of Neurology Faculty Papers

No abstract provided.

Enhancing Surgical Understanding Of Diabetic Foot Ulcer Classification Through Anatomage Integration: A Digital Approach To Wagner Grading, Nidhin John, Hooman Mir

School of Podiatric Medicine - Student Research

Background: Diabetic foot ulcers often lead to amputation, and accurate Wagner classification requires strong spatial understanding. Anatomage, a 3D digital anatomy tool, may improve this learning.

Methods: Thirty-six surgical trainees completed a pretest, explored digitally reconstructed Wagner grade 0–5 ulcers on Anatomage, and completed a posttest. Paired-sample analysis measured changes in accuracy, comprehension, and confidence.

Results: Classification accuracy improved from 61% to 89% (p < 0.05), with the greatest gains in higher Wagner grades. Participants reported clearer visualization of wound depth, bone involvement, and infection spread.

Conclusion: Anatomage enhances understanding and diagnostic precision of Wagner ulcer classification, supporting more effective limb-preservation education

Use Of Prophylaxis For Deep Venous Thrombosis And Pulmonary Embolism In Isolated Foot And Ankle Trauma, Regina Hansen, Alexander P. Rader, Naohiro Shibuya, Daniel C. Jupiter

School of Podiatric Medicine Publications

Background: Deep venous thrombosis (DVT) and pulmonary embolism (PE) are relatively rare after foot and ankle surgery, especially after trauma. Diagnosing DVT is difficult, and even when it is discovered it does not necessarily clinically manifest on, for example, duplex ultrasound. Thus, it is often recommended that prophylaxis use be assessed on a case-by-case basis based on risk profile rather than being uniformly given or not prescribed.

Methods: We searched the National Trauma Data Bank Trauma Quality Programs Participant Use File for patients experiencing foot and ankle trauma from 2013 to 2017. Patients were identified using the International Classification of …

Predictors Of Caregiver Satisfaction With A Hybrid Care Model For Autism Diagnostic Evaluations, Michele Kilmer, Emily Shah, Danielle Randolph, Lauren Quetsch

The Eleanor Mann School of Nursing Faculty Publications and Presentations

Background: Decreased access to diagnostic services is a known barrier in autism care management. Utilizing a hybrid care model incorporating telehealth and face-to-face appointments may be one option to increase access to care. The current study examined caregivers' satisfaction with a hybrid model used to administer pediatric autism diagnostic evaluations. Methods: We used a quantitative research design with convenience sampling to administer a telehealth satisfaction survey to caregivers of children living in medically underserved areas who were referred for an autism diagnostic evaluation. Timeliness and accuracy of diagnostic evaluations via the hybrid model were also assessed. Findings: Most caregivers did …

Design And Implementation Of Data Quality Controls In The Eq-Daphnie Study: Insights From The Pilot Phase And 15-Country Analysis, Fatima Al Sayah, Hilary Short, Juan M. Ramos-Goñi, Rosalie Viney, Erica I. Lubetkin, Mathieu F. Janssen, Jeffrey A. Johnson

Publications and Research

Objective

The EQ-DAPHNIE (EuroQol Data for Assessment of Population Health Needs and Instrument Evaluation) project is a large, multi-country survey initiative designed to generate population norms and enable comparative research using self-reported health measures. This paper describes the quality control processes and summarizes data quality metrics from the United Kingdom (UK) pilot and full implementation across 15 countries.

Methods

Representative samples were recruited via Dynata, an online survey panel provider, using quota sampling by age, sex, income, community setting, and language (where applicable). The UK pilot (n = 3012) informed survey refinements ahead of full rollout (n = 68,411). Quality …

Effects Of Neurocognitive Multitask Activities On A Novel Lower Extremity Functional Performance Test, Sidney M. Stoddard, Logan Hill, Bryan L. Riemann, George J. Davies

Physical Therapy Faculty Publications

Objective: To examine the effects of incorporating (1) a neurocognitive reactive component and (2) a neurocognitive multitask component on performance degradation of a single-limb hop functional performance test.

Design: Randomized within-subject design of 32 healthy young adults.

Methods: Participants performed 3 randomly assigned variations of the single-limb T-Drill Hop Test (TDHT). The time to complete each test was recorded. The reactive TDHT (R-TDHT) consisted of the TDHT with a flashing light, indicating the "T" intersection hop direction. The neurocognitive reactive-recall TDHT (RR-TDHT) incorporated the R-TDHT and required participants to observe 5 flashing light colors. Participants then recalled the colors in …

Hand Swelling And Other Non-Raynaud Phenomenon Symptoms As The Initial Presentation Of Systemic Sclerosis: Prevalence And Clinical Associations In Two Us Cohorts, Iqtidar Hanif, Shervin Assassi, Maureen D Mayes, Zsuzsanna H Mcmahan, Meng Zhang, Julio Charles, John M Vanburen, Jessica S Alvey, Kimia Ghaffari, Elana J Bernstein, Flavia V Castelino, Lorinda Chung, Luke Evnin, Tracy M Frech, Jessica K Gordon, Faye N Hant, Laura K Hummers, Dinesh Khanna, Kimberly S Lakin, Dorota Lebiedz-Odrobina, Yiming Luo, Ashima Makol, Jerry A Molitor, Duncan F Moore, Carrie Richardson, Nora Sandorfi, Ami A Shah, Ankoor Shah, Victoria K Shanmugam, Virginia D Steen, Elizabeth R Volkmann, Carleigh Zahn, Brian Skaug

Faculty, Staff and Student Publications

Objective: Raynaud phenomenon (RP) is often the initial clinical manifestation of systemic sclerosis (SSc), but some patients develop other manifestations first. To help elucidate the diversity of SSc presentation in its early stages, we describe the initial clinical manifestations and antinuclear antibody (ANA) profiles of patients in two early SSc cohorts.

Methods: All patient data in the Genetics vs Environment in Scleroderma Outcomes Study (GENISOS) and Collaborative National Quality and Efficacy Registry (CONQUER) cohorts were reviewed. Both studies enrolled patients within five years of the first non-RP symptom.

Results: In GENISOS and CONQUER, respectively, 194 (44.2%) of 439 and 292 …

A House Divided: A Mixed Method Investigation Of Primary Care Interprofessional Teams Using The Core Principles And Values Of Teamwork Framework, Erin L. Kelly, Catherine Guariglia, Jeanne Felter, Dhruvi Shah, Brooke Mauriello, Amy Cunningham, Chris Arenson, Randa Sifri

Department of Family & Community Medicine Faculty Papers

Context

Primary care teams are facing increased demands, turnover, and escalating rates of burnout. A primary care team aligned in its core values and organized according to common teamwork principles is essential for delivering patient-centered, coordinated, and effective healthcare.

Methods

As part of a series of studies on workplace factors and burnout among primary care practice team members, we selected an urban practice with high rates of burnout to assess their teamwork via a practice-wide survey and six focus groups divided by role. The interview guide focused on identifying areas for potential intervention around teamwork. Transcripts were open-coded using a …

A Novel Method For Examining Autistic Children’S Comprehension Of Individual Words Produced Within Delayed Echolalia: A Proof-Of-Concept Pilot Study, Janine Mathee-Scott, Grace Corrigan, Emily Lorang, Zachary Hesse, Jennifer Johnson, Courtney E. Venker

Speech Pathology and Audiology Faculty Research and Publications

Delayed echolalia, or the repetition of previously heard speech, is often observed in the expressive language of autistic children. Relatively little is known about how the production of delayed echolalia fits within the overall picture of autistic children’s language ability, including receptive language. To date, no empirical studies have tested autistic children’s comprehension of individual words within their delayed echoes. The present study aimed to establish proof-of-concept for a novel method of examining children’s comprehension of individual words that they produce in their own delayed echoes. Using natural language sampling combined with parent report, we identified instances of delayed echolalia …

Too Loud To Ignore: Knowledge, Attitudes, And Practices Regarding Hearing Protection In Student Musicians And Ensemble Directors, Lucile Donald, Ashley G. Flagge

Ashley Flagge Publications

Musicians are at an elevated risk for noise-induced hearing loss (NIHL) due to repeated exposure to sound levels exceeding occupational safety guidelines. Although many strides have been made in educating music students on the potential dangers of noise exposure and the mitigating effects of hearing protection devices, the current attitudes on this topic among high school and college-level student musicians remain largely unknown. An electronic survey was administered to high school (n = 195) and university (n = 161)-level band students and ensemble directors (n = 15) regarding knowledge of noise/music-induced hearing loss (MIHL), personal practices with HPDs, and types …

Vestibular Migraine And Ssri Withdrawal: A Case Report, Grace Fairchild, Sarah Redding, Ashley G. Flagge

Ashley Flagge Publications

Vestibular migraine (VM) has been described as a diagnosis of exclusion, with no one singular definitive assessment for diagnosis. It has been suggested that possible pharmaceutical intervention for VM can include antidepressant drugs, but this is potentially complicated by the fact that dizziness is a common side effect of both use and withdrawal for certain types of antidepressant medications. This article describes the case of a 56-year old with probable VM, who was previously diagnosed with depression and treated with the selective serotonin reuptake inhibitor (SSRI) Citalopram. Following discontinuation with no taper, the patient experienced a series of withdrawal side …

Use Of An Electronic Medical Record Tool To Ensure Tertiary Survey Compliance In Pediatric Trauma Patients, Ryan T. Davis, Erica Surman, Begum Akay, Nathan Novotny, Anthony Stallion, Pavan Brahmamdam

Conference Presentation Abstracts

Introduction:
The purpose of the tertiary survey is to ensure that traumatic injuries that may be missed during the primary and secondary survey are identified and treated accordingly. After a review, our trauma program identified a quality gap where tertiary surveys were not being documented. The purpose of this study is to evaluate whether the use of an electronic medical record tool, in conjunction with a reporting process, improved documentation of the tertiary survey in pediatric trauma patients.

Methods:
A review of the pediatric trauma database was performed. Patients < 16 years old who were admitted after level 1 or 2 activations or trauma evaluations were included. The study period was between January 2023 and January 2024. An Epicâ„¢ SmartPhrase was developed with input from the pediatric surgery team, pediatric trauma nurse manager, and the general surgery residents. The residents and pediatric surgery attendings were educated and the smartphrase was implanted July 2023. Reviews were made on a month-to-month basis and if a patient did not have a tertiary survey documented, emails to the trauma attending and residents of record were sent, notifying them of missed documentation of a tertiary survey.

Results:
Tertiary survey documentation compliance in the six months prior to …

Lymphoma Imaging In Hiv And Non-Hiv Patients: A Retrospective Cross-Sectional Study With Clinical And Pathological Correlation, Poonamjeet Loyal, Edward Chege, Jasmit Shah, Anne Mwirigi, Samuel Gitau

Imaging & Diagnostic Radiology, East Africa

Background: Patients with Human Immunodeficiency Virus (HIV)have an atypical imaging pattern of lymphoma. There is paucity of literature on differences in tumor volume or burden of disease amongst HIV positive patients compared with HIV negative patients and how this correlates with clinicopathological parameters of aggressiveness and prognosis.

Methods: This was a retrospective cross-sectional study of patients with non-Hodgkin lymphoma which were categorized into HIV positive and HIV negative. The tumor burden, disease sites, international prognostic score and Ki-67 index were recorded. Continuous variables were analyzed using the Kruskal Wallis test and categorical variables with Fisher’s Exact test.

Results …

Not All That Hurts Is Malignant: A Painful Case Of Focal Nodular Hyperplasia, Zamanali Khakhar, Abdullahi Abdigafar Yunis, Dayib Buthul, Khadija Warfa, Soraiya Manji, Rajiv Patel, Sayed Ali Raza Bukhari

Imaging & Diagnostic Radiology, East Africa

Focal nodular hyperplasia (FNH) is a benign hepatic lesion most often detected incidentally during imaging studies. While typically asymptomatic, a small subset of patients may present with abdominal pain or discomfort. Clinically and radiologically, FNH can mimic malignant liver tumors, occasionally resulting in unnecessary invasive procedures. This case report describes a 45-year-old woman with symptomatic FNH who was placed on routine imaging surveillance and managed conservatively. This case underscores the importance of accurately distinguishing this benign condition from hepatic malignancies. It further highlights the diagnostic challenges associated with achieving a definitive diagnosis.

A Rare Case Of Ogilvie’S Syndrome In A Pediatric Patient With A Complex Medical History, Kirby Lampe, Victoria Sarata, Aileen Har

Posters

Acute colonic pseudo-obstruction (ACPO) or Ogilvie’s syndrome is an acute dilatation of the small or large bowel without an obstructive lesion. Symptoms include abdominal distension, nausea and vomiting, constipation and occasional dyspnea. The disorder most commonly involves the cecum and right colon and is most frequently seen in male patients above the age of 60 (1). It is rare for Ogilvie’s to occur in the pediatric population though some infrequent instances have been reported. Here, we report a case of a patient with significant abdominal distension and gaseous distension seen on x-ray, which was diagnosed and treated as Ogilvie’s syndrome. …

A Case Report: Ansa Pancreatica As A Cause Of Recurrent Pancreatitis, Chase Branstetter, Elizaveta Khenner, Victoria Sarata, Nadia Ibrahimi

Posters

No abstract provided.

Challenges And Opportunities With Providing Genetic Testing And Counseling For Mucopolysaccharidosis Type Ii In Kenya, Lucy Mungai, Charles Njeru, Allan Njoroge, Michuki Maina, Syokau Ilovi, Dalton Wamalwa, Ruth Nduati, Beatrice Odongkara, Danny Miller

Pathology, East Africa

Background Limited or absent genetic counseling and testing resources in low- and medium-income countries lead to missed or late diagnoses for treatable metabolic conditions with irreversible complications. In some communities, misunderstanding about the etiology of a genetic condition may lead women whose children are affected to be viewed as a bad omen and become stigmatized or ostracized from their community. Mucopolysaccharidosis type II (MPS II), or Hunter syndrome, is a lysosomal storage disorder in which deficiency or inactivity of the enzyme iduronate-2-sulfatase leads to accumulation of glycosaminoglycans throughout the body. The diagnosis can be made through clinical assessment, enzyme activity …

Enhancement Of Antimicrobial Activity Of Truncated Cecropin B Peptides With The Substitution Of Tryptophan Residues, Sarah Smith, Christopher Feudale, Josephina R. Vermillion, Joseph Feudale, Joshua Do, Sabrina Arroyo, Juan Barrera, Madeleine Whitsitt, Marion Duval, Colby Grames, Bret Hatzinger, Makenzie Hilling, Tia Kean, Jasayle Rivera, Mia Shum, Hannah Zyra, David Rovnyak, Moria C. Chambers

Faculty Journal Articles

Cecropins are a class of antimicrobial peptides (AMPs) expressed by insects that have broad-spectrum antimicrobial activity and low cytotoxicity. However, cecropins are also long (40–45 amino acids) peptides, making their adaptation for therapeutic use challenging. Here, we present a series of 16 amino acid-long peptides derived from cecropin B from Drosophila melanogaster. The native truncated peptide is cationic and expected to form an amphipathic α-helix, but does not have antimicrobial activity. The incorporation of two Trp residues, depending on the position in the peptide backbone, results in antibacterial activity compa-rable to that of full-length cecropin B against the gram-negative bacteria …

The Battle Over Water Fluoridation Comes To New York City: Organized Dentistry Is Quick To Respond To Ill-Conceived Effort To End 60-Year Practice And Vows To Stay With It Until The Threat Passes., Lance Plunkett Jd, Llm

The New York State Dental Journal

Water fluoridation has been experiencing its woes lately, beset by an adverse court decision, questionable science, collapsing federal public health priorities and public suspicion often fueled by hysteria. Against all this, New York City stood strong as a pioneering large municipality safely fluoridating its water since 1965 for the benefit of the public and reducing dental caries significantly over decades.

A Qualitative Assessment Of The Role Of Dental Specialists In The United States Opioid Epidemic: Dental School Faculty And Postdoctoral Trainee Perspectives, Rochisha Singh Marwaha D.D.S., M.P.H., Ficd, Gunnar Hasselgren D.D.S., Ph.D., Sarah Douglas-Broten D.M.D., M.P.H., Sidney B. Eisig D.D.S., Kavita P. Ahluwalia D.D.S., M.P.H.

The New York State Dental Journal

This research used qualitative methods to compare the prescription opioid-related knowledge, opinions and behaviors of oral surgery (OS) and endodontics (E) faculty and postdoctoral trainees. Semi-structured interview guides were used to conduct 10 key-informant interviews with faculty and focus group discussions with 18 postdoctoral trainees. Interviews and focus group discussions were recorded, transcribed and coded for thematic content. E faculty reported infrequent use of opioids for dental pain management, while OS faculty frequently prescribed opioids. Conversely, E faculty were more likely to use prescription drug monitoring programs to track patients’ potential for addiction compared to OS. In conclusion, the frequency …

Real-World Impact Of Amiodarone On Apixaban Population Pharmacokinetics In Hospitalized Patients, Samantha Kolowrat, Chazmyn Riley, Kevin Lam, Lynda Thomson, Douglas F. Stickle, Walter K. Kraft

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Despite common coadministration in nonvalvular atrial fibrillation (NVAF), there is minimal evidence regarding the impact of concomitant amiodarone use on apixaban pharmacokinetics (PK). We described the population PK of apixaban (2.5 and 5mg twice daily) in 106 hospitalized patients with and without concomitant amiodarone administration at steady state. Apixaban PK was reasonably described by a one-compartment model with first-order absorption and linear elimination. Aside from the receipt of amiodarone, age was retained as a statistically significant covariate on apparent clearance. Model-based simulations depicted concomitant amiodarone use increasing AUCT for both 2.5mg (1.58, 90% CI [1.28, 1.87]) and 5mg (1.12, 90% …

Mortality Among Transgender Persons: A Taiwan Matched-Population And Sibling-Comparison Cohort Study, Chih-Wei Hsu, Yang-Chieh Brian Chen, Liang-Jen Wang, Mu-Hong Chen, Yao-Hsu Yang, Chih-Sung Liang, Po-Yen Chen, Edward Chia-Cheng Lai

Children’s Nutrition Research Center Staff Publications

Background: Transgender persons have been reported to experience excess mortality, but evidence is dominated by Western cohorts and seldom addresses familial confounding.

Methods: We conducted a nationwide, retrospective cohort study using two prespecified comparison designs: matched population controls (1:4, matched on legal sex and birth date) and within-family cisgender sibling comparisons. Transgender persons were identified by ≥2 psychiatrist-recorded gender identity disorder diagnoses during 2001-2021; cohort entry required age ≥6 years. Participants were followed until death or December 31, 2022. We compared all-cause, external-cause (suicide and accidents), and internal-cause mortality using Cox regression adjusted for sociodemographics and medical comorbidity.

Findings: Among …

Concerns Regarding The Standard Deviation Of Individual Responses For Assessing Treatment Response Heterogeneity, Aaron R Caldwell, David B Allison, Andrew W Brown, Gary L Gadbury, Thirupathi Reddy Mokalla, R Drew Sayer, Andrew D Vigotsky

Children’s Nutrition Research Center Staff Publications

The estimation of treatment response heterogeneity (TRH) is increasingly important as medicine moves toward personalized approaches. While various statistical methods have been proposed to quantify TRH in parallel-group trials, the standard deviation of individual responses (SDIR) has gained prominence within physiological research. This method is intended to quantify individual response variation by comparing standard deviations of change scores between intervention and control groups. We acknowledge that SDIR represents an improvement over many other flawed approaches that often involve responder counting. However, SDIR has critical limitations: 1) it cannot overcome the fundamental problem of causal inference because the correlation between potential …

Is Ageism A Problem In Dentistry? It Would Appear That No One Or No Segment Of Society Is Immune From Acting Questionably—And, Possibly, Illegally—Toward Seniors., Stuart Segelnick Dds, Ms

The New York State Dental Journal

While attending local, stat and national dental meetings through the years, and even the most recent NYSDA House of Delegates meeting, I am repeatedly surprised to hear comments from senior society officers decrying the “old men in the room” and declaring they have had “enough of the old whitehaired men” dominating the higher echelons of our organization. The younger dentists listening nod their heads in approval. What these well-meaning, experienced dentists were trying to highlight was the need to have younger and more diverse dentists involved in organized dentistry.

Attitudes Of New York State Pediatric Dentists Toward Treating Hasidic Patients, Gideon Turk Dmd, Michelle Goldstein Dmd

The New York State Dental Journal

Purpose: This survey investigated variations in practices among pediatric dentists and dental residents in New York State concerning the treatment of Hasidic, Haredi or Ultra-Orthodox Jewish (HHUOJ) patients.

Methods and Results: The 16-question survey was distributed to 641 AAPD pediatric dentists and residents via email. Results were analyzed across six variables using the Mann-Whitney U Test. Statistically significant differences were observed in the responses to 14 of 16 questions.

Conclusion: The study revealed statistically significant variations in various aspects related to the treatment of HHUOJ patients, suggesting the need for further education among providers in New York State.

Revolutionizing Dental Operatories: How Do We Do More Using Less?, Michael Zidile D.D.S., Brian Choi D.D.S.

The New York State Dental Journal

The authors present a transformative approach to modernizing dental operatories as part of their practice’s recent expansion. Aimed at enhancing efficiency and patient-centered care, the project reimagines traditional operatory design by eliminating ergonomic and hygienic barriers, notably, the use of keyboards and mice. Key innovations include the implementation of touchscreen PC displays, high-power PCs with graphics cards, magnetic USB cables for rapid data transfer, omnidirectional microphones linked to AI scribes and wireless intraoral scanning. The design prioritizes a standardized, clutter-free layout across eight operatories, utilizing A-Dec Inspire Series cabinets for ergonomic supply management. By removing countertops and pullout trays, the …