Medicine and Health Sciences Commons^™

Relationship Between Nontraditional Lipid Parameters And The Risk Of Type 2 Diabetes In Individuals Recovered From Dyslipidemia: A Cohort Study, Yuxian Wang, Zekai Chen, Zhen He, Hailun Qin, Kuangyi Wu, Huancong Zheng, Peng Fu, Zefeng Cai, Weiqiang Wu, Yulong Lan, Dan Wu, Shouling Wu, Youren Chen

Research outputs 2022 to 2026

Aims/Introduction: Lipid profiles are essential for assessing type 2 diabetes (T2D) risk, but individuals who recover from dyslipidemia are often overlooked, leaving their residual risk unclear. This study aimed to evaluate T2D risk in individuals with varying lipid change patterns and investigate the associations between traditional and novel lipid parameters with T2D risk among those recovered from dyslipidemia. Materials and Methods: In this prospective cohort study of the Kailuan Study, 39,283 non-diabetic participants were followed to evaluate T2D risk across lipid change patterns using the Cox proportional hazards models. A subset of 3,850 individuals recovered from dyslipidemia was analyzed to …

The Acute Effects Of Caffeine, Creatine, And Carbohydrate Mouth Rinse Combined With Conditioning Activity On Subsequent Sports Performance: A Systematic Review And Bayesian Meta-Analysis, Yanfeng Li, Bopeng Qiu, Hongyan Kuai, Kongyun Huang, Hengxian Liu, Mingyang Zhang, Mingyue Yin, Yilin Zhang, Hengzhi Deng, Yuming Zhong, Hao Kong, Jun Chen, Kai Xu

Research outputs 2022 to 2026

Background: Post-activation performance enhancement (PAPE) refers to the acute improvement in sports performance following a conditioning activity (CA), commonly used in warm-up protocols and complex training. While CA alone has demonstrated performance benefits, the effects of combining CA-induced PAPE with supplements (e.g., caffeine, creatine, or carbohydrate mouth rinse) remain unclear. Objectives: This study was to (i) assess the effects of PAPE combined with supplements on sports performance and fatigue resistance compared to PAPE + placebo, warm-up + supplements, or warm-up alone, and (ii) synthesize direct and indirect evidence on performance outcomes using network meta-analysis. Methods: Searches were conducted across three …

Enhancing Cardiovascular Risk Prediction In Hypertensive Adults: A 3pm-Based Evaluation Of Insulin Resistance And Arterial Stiffness, Yulong Lan, Zhaogui Wu, Dan Wu, Lingyu Xu, Hongfa Wei, Chutao Wu, Youren Chen, Xiaolan Li, Shouling Wu

Research outputs 2022 to 2026

Objective: Hypertension management remains challenging due to coexisting insulin resistance (IR) and arterial stiffness—two silent yet synergistic drivers of atherosclerotic cardiovascular disease (ASCVD). This study aimed to evaluate their joint impact on ASCVD risk and assess their utility in predictive, preventive, and personalized strategies. Methods: In this prospective cohort study of 30,094 adults with hypertension, IR was assessed using the triglyceride-glucose (TyG) index (calculated as ln [TG (mg/dL) × FBG (mg/dL)/2]) and arterial stiffness via brachial-ankle pulse wave velocity (baPWV). Time-to-event analyses examined their individual and combined associations with ASCVD incidence. Results: Over a median 5.6-year follow-up, 1655 ASCVD cases …

Intake Of Total, Classes, And Subclasses Of (Poly)Phenols And Risk Of Lymphoid Neoplasms: A Prospective Analysis In The Epic Cohort, Enrique Almanza-Aguilera, David Guananga-Álvarez, Yolanda Benavente, Alexandra Nieters, Caroline Besson, Fatemeh Saberi Hosnijeh, Cecilie Kyrø, Nicola P. Bondonno, Christina C. Dahm, Elisabete Weiderpass, Therese Truong, Mariem Louati-Hajji, Xuan Ren, Verena Katzke, Matthias B. Schulze, Fabrizio Pasanisi, Claudia Vener, Giovanna Masala, Maria Teresa Giraudo, Rosario Tumino, Amaia Aizpurua, Maria Jose Sánchez, José María Huerta, Marcela Guevara, Cristina Lasheras, Paolo Vineis

Research outputs 2022 to 2026

Background: Existing epidemiological evidence regarding the potential role of (poly)phenol intake in lymphoma development is limited. Methods: We investigated the associations between the intake of total and individual classes and subclasses of (poly)phenols and the risk of lymphoma, including main frequent subtypes in the EPIC cohort using multivariable-adjusted Cox proportional hazards models. Results: During a mean 14-year follow-up (time frame: from 1990–1994 to 2008–2013), 2394 incident lymphoma cases were diagnosed from a total of 367,463 individuals. No significant associations were observed between total intakes of (poly)phenols, flavonoids, and phenolic acids and overall lymphoma risk. Total (poly)phenols, phenolic acid and hydroxycinnamic …

A Scoping Review Of Randomised Controlled Trials Of Vaccines That Recruited Care Home Residents: Lessons For Future Trials, Selvarani Selvarani Subbarayan, Imogen Smith-Dodd, Gabriel Nicolson, Jennifer Kirsty Burton, Janet T. Scott, Seshadri S. Vasan, Susan D. Shenkin, Roy L. Soiza

Research outputs 2022 to 2026

Introduction: Older care home (CH) residents are particularly vulnerable to infections and often experience adverse outcomes. Despite this group being frequently prioritised for vaccinations, trials of vaccines rarely recruit CH residents. Given that the social and biological characteristics of CH residents may influence vaccine effectiveness, it is crucial to test vaccines in this population.

Methods: The Widening Access to Trials in Care Homes project was established to develop best practice guidance on designing and conducting vaccine trials in the CH population. As part of this project, a scoping review following Joanna Briggs Institute methodology was conducted to identify vaccine trials …

Distinct Contributions Of Cerebrospinal Fluid Biomarkers To Cognitive Impairment And Neuropsychiatric Symptoms In Young-Onset Dementia, Wei Hsuan Chiu, Anita M.Y. Goh, Dhamidhu Eratne, Charles B. Malpas, Matthew J.Y. Kang, Wendy Kelso, Mark Walterfang, Dennis Velakoulis, Samantha M. Loi

Research outputs 2022 to 2026

Objective: Young-onset dementia (YOD), defined by symptom onset before age 65, encompasses diverse aetiologies and presents with prominent neuropsychiatric symptoms (NPS) that often accompany or exacerbate cognitive decline. However, the pathological mechanisms linking NPS, cognition, and biomarkers remain unclear. It was hypothesised that relationships between NPS and cognition would be mediated or moderated by cerebrospinal fluid (CSF) biomarker levels in individuals with YOD. Methods: This retrospective, cross-sectional study included 46 participants with YOD (24 with Alzheimer's disease [AD], 22 with non-AD dementias) diagnosed at the Neuropsychiatry Centre, Royal Melbourne Hospital. NPS were measured using the Depression Anxiety and Stress Scale …

From The Icu Bedside: Applying The Transnational Clinical Academic Doctorate Lens To A Clinically Embedded Phd Journey, Gideon U. Johnson

Research outputs 2022 to 2026

Aim: To critically reflect on a transnational, clinically embedded doctoral journey undertaken during and after the COVID-19 pandemic, and to draw conceptual and systemic lessons for doctoral education and clinical academic nursing pathways. Background: Reflective accounts of doctoral study exist, yet few examine practice-based PhDs conducted across different countries and health systems during a global crisis. This paper analyses one such pathway—enrolment at an Australian university with research embedded within the UK National Health Service—to explore resilience, identity formation, mentorship ecologies and organisational conditions that support or hinder clinical academic development. Method: Using analytic autoethnography and reflective case study logic, …

Navigating Ethical Complexities In Health Education: Exploring Challenges In Teaching Food And Health, E. Oljans, M. Quennerstedt, D. Barker, A. Caldeborg, V. Varea

Research outputs 2022 to 2026

Teaching food and health may be challenging, especially in classrooms where young people from different cultures, ethnicities, and religions meet. This article explores teachers’ navigation of ethical complexities when teaching food and health in classrooms with immigrant students. Five didactical strategies were identified: (1) The educare strategy, (2) The tiptoeing strategy, (3) The collegial support strategy, (4) The intercultural strategy, and (5) The pluralistic strategy. These didactical strategies are embedded in various educational settings. Our results demonstrate that a further focus on ethical and intercultural competence should be carefully supported and implemented in teacher education and continual professional development programmes …

Sorghum And Sorghum-Based Products: Nutritional Composition, Prebiotic Potential And Health Benefits In Gut Microbiota Interactions, W. M.A.D.Binosha Fernando, Rasheed A. Abdulraheem, Kalmee Pramoda Kariyawasam, Amal Sudaraka Samarasinghe, W. M.Kendrea T. Fernando, Hannah Barnes, Malina Robertson, D. P.W. Jayatunga, B. G.D.N.K. De Silva, Vijay Jayasena

Research outputs 2022 to 2026

Sorghum (Sorghum bicolor L.) is a member of the Poaceae family and is the fifth most important crop globally. Sorghum grains (SGs) are rich in health-promoting macro- and micronutrients and phytochemicals. SGs are commonly consumed as food or as ingredients in food, especially in African countries. Therefore, food products such as ogi, bread and flour have been and are still being developed from SGs to provide nutritional and health benefits. However, the nutritional and prebiotic potential of SGs, especially the pigment pericarps, has not been fully exploited. This review describes micronutrients in different varieties of sorghum and the health benefits …

Improving Hpv Vaccine Rates For Aboriginal Young People Through A Social Media Campaign: An Interrupted Time Series, Natalie A. Strobel, Jocelyn Jones, Kim Gates, Simon L. Turner, Joanne E. Mckenzie, Daniel R. Mcaullay

Research outputs 2022 to 2026

Human papillomavirus (HPV) is a common sexually transmitted infection that can lead to HPV-related cancers such as cervical cancer and other cancers such as anal, vaginal, and penile cancer. HPV rarely produces symptoms and cannot be cured or treated; therefore, vaccination is essential to protect against HPV and HPV-related diseases. However, young Aboriginal and Torres Strait Islander (hereafter, respectfully, ‘Aboriginal’) people are not receiving their HPV vaccine dose, resulting in missed opportunities to be protected from HPV-related cancers. Health promotion is a critical way to empower people to take ownership over and control their health and is a core function …

Can The Ability To Infer Relevance Account For Dimensional Psychoticism? An Exploration Of A Representative Community Sample, Adam Schwarz, Frank D. Baughman, Evan Dauer, Ruby Koyllor Alarcon Gleeson, Jennifer Haywood, Bo Huei Huang, Karen H. Heslop, Barbara A. Mullan, Susan L. Rossell, Nicolas H. Hart, Darren Haywood

Research outputs 2022 to 2026

Purpose: Psychoticism is a common feature of psychological disorders. Deficits in perceptual inference have been associated with the development of psychotic symptoms. Traditional testing of perceptual inference has had low ecological validity, limiting the ability to infer functional relationships. The aims of this study were to investigate the relationship between the capacity to infer relevance in dynamic environments and dimensional psychoticism, as well as to investigate the association between inferring relevance and dimensional psychoticism. Method: Four hundred participants, representative of the general population of the USA, completed an online questionnaire consisting of the Brief Symptom Inventory, as well as demographic …

Metadata Makes Big Data Useful For Ai/Ml-Ready, Equitable Pandemic Response, Sudarshan Anand, Miae Lee, Seshadri S. Vasan

Research outputs 2022 to 2026

While genomic data helps understand the pathogen and its evolution, patient metadata is critical to get the host side of the picture, so that the pandemic response is effective and equitable.

Clinical Relevance: We highlight the importance of patient stratification and metadata to help develop diagnostics, therapies and vaccines as the pathogen (virus) evolves.

Online Learning-Driven Human Intent Estimation And Control For Human-Robot Interaction, Irfan Ganie, S. Jagannathan

Electrical and Computer Engineering Faculty Research & Creative Works

This paper presents a novel Stackelberg-game theoretic multilayer-online learning framework for cooperative control of nonlinear Physical Human-Robot Interaction (pHRI), where the human is modeled as the leader guiding a robot follower. This hierarchical interaction is captured as a dynamic Stackelberg game, with the human's intention estimated in real-time through online multilayer neural networks (MNNs). We introduce SVD-based weight update laws for actor-critic MNNs, which approximate value functions and control inputs for both human and robot, eliminating the need for predefined basis functions. In this framework, the human objective is first inferred and used to guide the robot actions by shaping …

Improved Optimal Tracking Of Uncertain Nonlinear Discrete-Time Systems Using Experience Replay, Maxwell Geiger, Sarangapani Jagannathan

Electrical and Computer Engineering Faculty Research & Creative Works

This paper addresses the infinite horizon optimal tracking control problem for partially uncertain control-affine nonlinear discrete-time (DT) systems, where the control input dynamics are known. Multi-layer critic and actor neural networks (MNNs) are utilized for online estimation of the infinite horizon value function and optimal control input. The NN weights are tuned online using a direct temporal difference error (TDE)-driven learning approach, which modifies the singular values of the gradient with respect to the NN weights to accelerate their convergence. The critic NN uses a novel experience replay technique to improve sample efficiency without introducing biased TDEs and guarantee the …

Multi-Model Safe Neuro-Optimal Output Tracking Control Of Autonomous Surface Vessels With Explainable Ai, Behzad Farzanegan, S. Jagannathan

Electrical and Computer Engineering Faculty Research & Creative Works

This paper presents a safety-aware deep reinforcement learning (DRL)-based trajectory tracking control of autonomous surface vessels (ASVs). A multilayer neural network (MNN) observer estimates the ASV's state and uncertain dynamics. By utilizing the estimate state vector from the observer, a safety-aware DRL-based optimal policy is formulated using control barrier function (CBF) and Karush-Kuhn-Tucker (KKT) conditions. An actor-critic MNN with singular value decomposition (SVD)-based update mitigates vanishing gradients. To enhance adaptability, an online safe lifelong learning (SLL) scheme counters catastrophic forgetting across varying ASV dynamics. The Shapley Additive Explanations (SHAP) method identifies key features influencing the control policy. Simulations on an …

Online Adaptive Optimal Tracking Control Of Uncertain Strict Feedback Discrete-Time Systems With Hardware Verification Using A Quadrotor Uav, Maxwell Geiger, S. Jagannathan

Electrical and Computer Engineering Faculty Research & Creative Works

This article considers the infinite time horizon optimal tracking control problem for discrete time (DT) partially uncertain strict feedback systems with application to quadrotor UAVs. First, the strict feedback DT system is transformed into an equivalent affine nonlinear DT system in terms of tracking error dynamics. The optimal tracking control problem is solved using an augmented system approach, where a horizon of future reference trajectory points are used in the augmented state, as compared to using a single point. The internal dynamics of the original nonlinear strict feedback system and the transformed affine system in terms of error dynamics are …