Medicine and Health Sciences Commons^™

Obesity, Metabolic Health, And Diabetic Complications In People With Type 1 Diabetes., Yuanjie Mao, Jen-Tzer Gau, Ning Jiang

Ambulatory and Primary Care Articles

AIM: The concept of metabolically healthy obesity (MHO) has not been studied in type 1 diabetes (T1D). By analysing datasets from the DCCT/EDIC study, we compared the development of diabetic complications by obesity and metabolic health over 30 years of follow up.

MATERIALS AND METHODS: Insulin resistance was calculated by estimated glucose disposal rate (eGDR). The participants (n = 1127) were then divided into four groups based on time-weighted mean body mass index and mean eGDR: metabolically healthy non-obesity (MHN, n = 874), metabolically unhealthy non-obesity (MUN, n = 66), MHO (n = 146) and metabolically unhealthy obesity (MUO, n …

Identification Of Benzothiophene-Derived Inhibitors Of Flaviviruses By Targeting Rna-Dependent Rna Polymerase, Leah Liu Wang, Shazeed-Ul Karim, Aidan Hand, Ryan Brunkhorst, Mackenna Petersen, Sarah Altam, Yi Liu, Luwen Zhang, Fengwei Bai, Shi-Hua Xiang

School of Biological Sciences: Faculty Publications

Flaviviruses such as Dengue, West Nile, and Zika viruses are mosquito-borne RNA viruses that can cause serious diseases in humans. To develop effective drugs for treating these viruses’ infections, we create a new approach for developing common or shared drugs that may work for several different viral species of flaviviruses. It is based on the conserved RNA-dependent RNA polymerase (RdRp), which is the key enzyme for viral replication. We built up a common structure of RdRps (POLcon) from their consensus sequence. A conserved Triple-D structural motif was identified at the active site of POLcon that has been used for virtual …

Bacteria-Engineered Vesicles For Cancer Immunotherapy: From Immunomodulation In Vitro To Anti-Tumor Effects In Melanoma Models, Lan Li

Theses and Dissertations--Chemistry

Bacterial vesicles hold immense potential in various biomedical fields. Among these, outer membrane vesicles (OMVs) produced by Gram-negative bacteria are the most extensively studied. While the exact mechanism of OMV production remains unclear, numerous environmental factors have been shown to influence both their yield and composition. In this study, we investigated the effect of three different antimicrobial families on OMV production by E. coli. Interestingly, antimicrobials within the same family did not provide the same effects on OMV yield, suggesting that OMV production may not directly correlate with the antimicrobial mechanism of action. OMVs have demonstrated tumor-inhibitory activity in multiple …

Insights Into Factors Influencing Radical Coupling Chemistry Of Monolignols During Lignification And Induced Changes In Plant Secondary Metabolism, Rachel Poornima Sutherland

Theses and Dissertations--Chemistry

Lignin is a complex aromatic biopolymer and an important constituent in plant cell walls. The process of lignin biosynthesis, known as lignification, is poorly understood and challenging to study but has important implications in a variety of fields including sustainable energy, bioengineering, and materials science and is therefore of interest to pursue. In the final stage of lignification, H-, G-, and S-monolignols are oxidized by laccase and peroxidase enzymes to generate radical species that couple to form dimers and further oligomeric species to ultimately produce the lignin polymer. Biomimetic lignin model systems utilize in vitro oxidative coupling reactions as an …

The Impact Of A Unique Special Operations Team During A Prolonged Trench Rescue, Jillian Allen Do, Derek J. Fikse Do, Jeanne L. Jacoby Md, Jeffrey M. Kuklinski, Michael Nguyen, Eric Schneider Do

Department of Emergency Medicine

No abstract provided.

Promoting Health Equity – A Closer Look At Point-Of-Care-Ultrasound Echocardiogram Use In The Ed Setting, Christopher Connell Do, Elizabeth M. Evans Do, Ahsan Usmani, Kevin R. Roth Do, Facoep, Claire L. Paulson Do, Phillip M. Grenz Do, Hanna R. Warren Do, Marna R. Greenberg Do, Mph, Facep, Kevin Weaver D.O.,Facoep, Andrew Ferdock, Kristine L. Schultz Md

Department of Emergency Medicine

No abstract provided.

Yoga As A Self-Care Practice For Mental Health Counselors Who Treat Trauma, Kari Michelle Fitzgerald

Graduate Research Theses & Dissertations

Given the high rates of burnout and compassion fatigue among trauma-exposed counselors, understanding effective self-care practices is critical for sustaining clinical effectiveness and well-being. Utilizing Interpretative Phenomenological Analysis (IPA), exploration of the lived experiences of licensed mental health counselors who treat trauma and use yoga as a self-care practice was conducted. Eight participants who were regular yoga practitioners each participated in one semi-structured interview and submitted one pre- and one post-interview reflective journal entry. Thematic analysis was used to identify six major themes; 1) emotional impact and sacred responsibility of clinical work, 2) yoga as a regulating and restorative practice, …

"On The Mat They Will Get Treated The Same": Male High School Wrestlers' Attitudes Towards Female Opponents, Emily Ann Kaht

Graduate Research Theses & Dissertations

Wrestling has historically been considered a male sport. Until recently, so few girls wrestled that those who did had no choice but to take on male opponents. Media reports and the literature indicate that those girls faced a wide range of attitudes from their opponents. While some women reported feeling supported by their male teammates, others reported hostility. Some stakeholders have, in the past, argued that wrestling is inherently unsuitable for girls, and some girls had trouble securing matches due to widespread refusal of boys to wrestle against them. Reasons given for boys forfeiting against girls have included a fear …

Vascular Dementia, Kayley Anderson

The Art of Medicine

No abstract provided.

The Art Of Auscultation, Stephanie Dong

The Art of Medicine

No abstract provided.

"Neuroradiology And The Humanity Of It," "Skull With Ginko" And "Sphenoid", Andria M. Powers

The Art of Medicine

No abstract provided.

Ode To An Earthworm, Sarah Chandler

The Art of Medicine

No abstract provided.

Invisible, Heather Richard

The Art of Medicine

No abstract provided.

"Gratitude: Reflecting On Mentors And Mission Work" And "Facial Aging And Midfacial Fat Grafting Techniques", James Vargo

The Art of Medicine

No abstract provided.

After The Storm, Jill Zabih

The Art of Medicine

No abstract provided.

A Response To Kafka, Roshan Sapkota

The Art of Medicine

No abstract provided.

Beyond The Breaking Point, Drew Thodeson

The Art of Medicine

No abstract provided.

Redox Control In A Fused Electron Transfer Flavoprotein From A Thermophilic Archaeon And Expanded Significance Of A Hydrogen Bond From A Conserved Histidine Residue That Contributes To Flavin Redox Tuning And Activation For Covalent Modification, Debarati Das

Theses and Dissertations--Chemistry

In absence of O₂ as terminal electron acceptors in anaerobic bacteria and archaea, carbohydrate metabolism is 15 times less efficient compared to aerobic energy metabolism resulting in energy deficit conditions. Despite their meager resources these anaerobes were able to generate H₂ and a chemiosmotic potential able to drive energy demanding reactions such as CO₂ or N₂ fixation. These observations raised concerns as production of high energy reductants (H₂) from mediocre fuels (NADH) defied the laws of thermodynamics.

In 2008, a known mechanism “electron bifurcation” but with flavins as redox mediators instead of quinones was …

"Heart" And "Avah", Chloe Condrey

The Art of Medicine

No abstract provided.

"Flexor Digitorum Profundus," "Edge Of Tomorrow" And "Holy Sepulchre Circle Of Life", J.P. Miller

The Art of Medicine

No abstract provided.

Go Get Lunch, Emma Yackley

The Art of Medicine

No abstract provided.

Stranger's Hands, Austin Choat

The Art of Medicine

No abstract provided.

A Little Levity, Melissa Teply

The Art of Medicine

No abstract provided.

Arterial Genesis, Margarita Pipinos, Argyrenia Pipinos

The Art of Medicine

No abstract provided.

Healing Or Harm - Contemporary Controversies In Ink, Andrew Minchow

The Art of Medicine

No abstract provided.

Summer's Labor, Jacob Benes

The Art of Medicine

No abstract provided.

Red Sweater, Alicia Phillips

The Art of Medicine

No abstract provided.

"Clinic Emotions" And "Bad News", Rachel Sisley

The Art of Medicine

No abstract provided.

This Too Can Be Holy, Mitch Nohner

The Art of Medicine

No abstract provided.

The Warrior Within, Hannah Manoj

The Art of Medicine

No abstract provided.