Medicine and Health Sciences Commons^™

Categorizing Clinical Response To Mepolizumab For Patients With Chronic Rhinosinusitis With Nasal Polyps: Synapse Trial, Claire Hopkins, Larry Borish, Jared Silver, Peter Howarth, Robert Chan, Priya Dsilva, Joseph K. Han

Department of Otolaryngology (ENT) Faculty Publications

[Introduction] Chronic rhinosinusitis with nasal polyps (CRSwNP) can substantially affect quality of life (QoL), and is often challenging to manage.¹ First-line treatment for the management of CRSwNP involves intranasal corticosteroids, with short courses of systemic corticosteroids (SCS) for exacerbations, and sinus surgery for uncontrolled disease.² Biologics targeting type 2 inflammation (eg, dupilumab, omalizumab, and mepolizumab) have become a treatment option for refractory CRSwNP. With the advent of disease-modifying treatments such as biologics, control, defined as patients reporting no/low-symptom levels, has increasingly become the treatment goal for CRSwNP.³ However, the optimal use of biologics for symptom control in individual patients remains …

Acute Exacerbations Of Chronic Rhinosinusitis, Robert M. Frederick, Kent Lam, Joseph K. Han

Department of Otolaryngology (ENT) Faculty Publications

Purpose of Review

We aim to highlight recent advancements on the evolving chronic rhinosinusitis (CRS) phenotype: acute exacerbations of chronic rhinosinusitis (AECRS). We focused on studies that expanded the current understanding of its pathophysiology, patient characteristics, and disease burden.

Recent findings

Defining AECRS has been a topic of discussion for many years. A recent regulatory definition of AECRS in the literature incorporates a > 3 day requirement of worsened symptoms and an escalation of treatment. It is important not to rely on patient-reported rescue medication frequency as it was recently demonstrated these are only obtained for 1/3 of reported AECRS episodes. …

Technol-Ot And Creativity: Implementing Occupational Therapy (Ot) And Assistive Technology (At) Into Art And Music For Adults With Disabilities, Camille Alexandra Aquino, Aarti Subramanian, Austin Yee, Joshua Darrin Montano, Angelica-Kjristen Antonio

Occupational Therapy | MSOT Capstone Projects

Background: Assistive technology (AT) holds the potential to enhance independence and participation among individuals with Intellectual and Developmental Disorders (IDD) and physical disabilities. AT supports for adults with these disabilities remain limited in community settings after they transition out of the K–12 educational system. Addressing this gap requires collaborative, client-centered approaches to implementing effective AT solutions.

Purpose: This project aims to assess and address the AT needs of Marin Ventures (MV), an adult engagement day program, and seeks to develop and implement sustainable AT applications to enhance creative expression and communication for MV clients.

Methods: A needs assessment was conducted …

Exploring The Synergy Of Executive Functions And Sensory Processing In Shaping Occupational Participation, Isabella Aguirre, Kaitlin Mulvaney, Sophia Zertuche

Occupational Therapy | MSOT Capstone Projects

This study adds to the available literature on the relationship between executive functions (EF) and sensory processing (SP), and their combined effect on occupational participation (OP) in children aged 5-12 years. Understanding the nature of this relationship holds the key to identifying factors shaping a child's ability to engage effectively in daily life activities. The research team hypothesized that children with stronger EF and more efficient SP will demonstrate higher levels of OP, while those with challenges in either or both domains may experience limitations to effectively engage in daily activities. Participants consisted of parents of 26 children aged 5 …

Impact Of Sensory Diets On Occupational Performance, Kyndra Holloway, Cassandra Howard, Makena Collin, Princess Pillos

Occupational Therapy | MSOT Capstone Projects

This study investigates the impact of individualized sensory diets on children’s occupational performance in daily life. Sensory diets are structured, child-specific interventions designed to facilitate improved sensory processing by integrating activities into established routines. They involve a tailored home program plan, consistent application, and interventions aligned with the child’s specific sensory needs (Wilbarger, 1995).Using a multiple single-case study design, this research examined the outcomes of sensory diets prescribed alongside direct occupational therapy (OT) services for four white male children aged 3 years, 11 months to 5 years, and 8 months with neurodevelopmental disorders.

Participants were recruited through Developmental FX (DFX) …

Increasing Awareness Of Occupational Therapy For College Students At Dominican University Of California, Joshua James King Ng, Connor Efstathiu, Audrey Nakashima, Rylee Sarasua, Katie Szoboszlay

Occupational Therapy | MSOT Capstone Projects

Background: This project is the third iteration of the Occupational Therapy (OT) college student program at Dominican University of California aiming to promote OT Coaching services for students while enhancing occupational engagement in daily activities, and overall well-being. Occupational therapists play a distinctive role in postsecondary education (AOTA, 2013).The second iteration of the OT college student program (2022–2023) prioritized collaboration with the school’s Student Success Center (SSC) and on-campus Integrative Coaches (ICs) who played a pivotal role in streamlining client referrals and enhancing the program outcomes. During their time with the program, this group was able to flagship a program …

Resilience Programming For Occupational Therapy Students: A Mixed-Methods Exploration, Meghan Shellooe, Jalina Madriaga, Valerie Perez, Gabriela Velazquez

Occupational Therapy | MSOT Capstone Projects

Occupational therapy students and practitioners experience high levels of stress due to classroom and professional demands which can lead to burnout. Resilience is found as a protective factor against stress and burnout. Resilience can be defined as the different ways systems work together to achieve better results than expected, after experiencing adversity. Concepts related to resilience include social connection, self-efficacy, and mindfulness. Research done on resilience programming for students has been shown to support students in navigating the hardships of college. Resilience programming has been found to be effective for occupational therapists in the workplace during high work demands. However, …

Effects Of Invigorating And Relaxing Music On Heart Rate, Blood Pressure, And Heart Rate Variability, Matthew Joshua Faur

Honors Undergraduate Theses

Heart-rate variability (HRV) has been documented to correlate with several health measures, including autonomic nervous system longevity and athletic performance (Zulfiqar, 2010). While increasing age does not affect heart rate, there is a steady decline in HRV, which is a biological marker of aging and the decline of autonomic nervous system function. Furthermore, men who exercise regularly tend to have increased HRV, suggesting a mitigation of the typical age-dependent loss of HRV (Kristal-Boneh et al., 1995). Previous studies have suggested that music may have a physiological effect (e.g., fluctuating vitals, emotional changes) on cardiovascular parameters. However, little is known about …

Associations Between Brain White Matter Hyperintensities And Diet Quality In Cognitive Aging: A Cross-Sectional Assessment, Carla V. Urdaneta

Honors Undergraduate Theses

Leukoaraiosis, or White Matter Lesions (WMLs)/White Matter Hyperintensities (WMHs), are often considered markers of aging and neurodegeneration. White matter hyperintensities appear as lighter, hyperintense regions on T2-weighted fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) scans and are physiologically characterized as demyelination and axonal loss reflected as microvascular lesions in cerebral white matter (Marseglia et. al., 2019). These anatomical landmarks are most seen in MRIs of elderly individuals. They can be associated with aging and cognitive decline, including affected frontal lobe function and episodic memory in the form of delayed recall performance and are linked to several cardiovascular risk factors, …

A Review Of The Utilization Of Comics In Research And The Potential For Graphic Medicine Integration In Health Science Communication, Nagatarang Nimmathota

Honors Undergraduate Theses

Communication is a vital part of research, both during its conduction and the dissemination of its findings. This can be difficult to achieve due to factors like knowledge disparity, technical jargon, and differing backgrounds. This narrative literature review draws from databases like PubMed, ScienceDirect, and others to examine the current utilization of graphic medicine in research and its effects on health research communication. This review found that the integration of graphic medicine can help alleviate those issues by simplifying complex topics into engaging visual narratives or comics for consumption by research participants and the public. Additionally, the use of graphic …

Respiratory Cycle Influence On Lumbosacral Muscle Function: A Tensiomyographic Analysis, Anthony Trombetta

Honors Undergraduate Theses

Introduction:

Tensiomyography (TMG) has significant potential in examining muscle functionality while evading the limitations found in other methods muscle analysis. Specifically, the erector spinae and other lumbosacral muscles can be analyzed with little challenge. Such analyses include data on muscle displacement (Dm), delay time (Td), contraction time (Tc), half-relaxation time (Tr), and sustain time (Ts). Of these parameters, the most evaluated and with the highest level of reliability are Dm, Td, and Tc. However, stiffness of the lumbar spine and lumbosacral muscles fluctuates throughout the respiratory cycle. These fluctuations may pose an issue when examining the functionality of muscles. This …

Cannabis Use And Functional Independence Among Older Adults: The Health And Retirement Study, Jade Alaine Perry

Honors Undergraduate Theses

As people age, negative cognitive effects become more common, and the likelihood of chronic disease diagnoses increases. Many older adults suffer from one or more chronic health issues that have serious impacts on both their mental and physical health. Chronic pain is also known to increase in prevalence as we age. Opioid use to treat chronic pain among older adults is worrisome due to the likelihood of drug-drug interactions due to polypharmacy and the risk of problematic opioid use that can lead to overdose. Cannabis use both medical and recreational has become more acceptable among the aging adult population in …

Effects Of Resistance Exercise On Post Stroke Patients: Systematic Review Of The Literature, Jeslin Patel

Honors Undergraduate Theses

Individuals who suffer from post-stroke effect face loss of function in mobility and quality of life. Mobility issues lead to changes in walking patterns, strength ability, daily independence, and more. Resistance training is an effective rehabilitation method used to test improve recovery by enhancing well-being, reducing spasticity, and increasing control. The purpose of this study was to explore the effects of resistance exercise on post-stroke patient's recovery and return to activities of daily living. A systemic literature review using databases, key terms, and various strategies. Databases used consisted of UCF Libraries, PubMed, Google Scholar, SagePub, Medline, ScienceDirect, and EBSCOhost. These …

Investigating The Effects Of A Psychoplastogen On Depressive-Like Behaviors In Huntington Disease Model Mice, Kaleigh M. Hanley

Honors Undergraduate Theses

Huntington Disease (HD) is a neurodegenerative disorder caused by an expansion in the trinucleotide CAG repeat on exon 1 of the huntingtin gene. In HD one of the first symptoms is often depression. In cases where SSRIs fail, treatments for treatment-resistant depression often become a patient’s only option. These rigorous treatments, such as electroconvulsive therapy, are not suitable for this patient population as it can worsen motor symptoms. In order to search for potential alternatives, we queried whether depressive-like behavior could be reduced in Hu97/18 and Q175FDN HD mice by administering tabernanthalog, a non-hallucinogenic psychedelic analog. Our study is not …

Comparative Efficacy Of Hallucinogens In Treating Mood Disorders Through A Meta-Analysis Of Symptom Reduction, Dosage, And Duration, John Marco D.F. Muniz

Honors Undergraduate Theses

Background: Hallucinogens including psilocybin, lysergic acid diethylamide (LSD), ketamine, N,N-dimethyltryptamine (DMT) (as ayahuasca), have re-emerged as potential rapid-acting treatments for mood disorders. We conducted a meta-analysis of placebo-controlled trials evaluating their efficacy in depression and anxiety disorders. Methods: A systematic review identified 12 trials (Total ≈ 670) meeting inclusion criteria (randomized, placebo-controlled). Data on Cohen’s d and Hedges’ g effect sizes for depression- and anxiety-related outcomes were extracted. We computed pooled effect sizes (weighted by sample size and inverse variance), performed subgroup analyses by drug, diagnosis, follow-up duration, and outcome measure type, and assessed heterogeneity (I², Q …

Effect Of Metal Ions On The Reactive Oxygen Species Scavenging Capabilities Of Cerium Oxide For Biological Applications, Agastya Mittal

Honors Undergraduate Theses

Ceria nanoparticles' capabilities to defend cells against oxidative stress through superoxide dismutase activity are well-documented. Ceria nanoparticles demonstrate a ratio between 3⁺/4⁺ oxidative states on the surface of the particles to exhibit oxygen vacancies, a feature that allows these particles to scavenge Reactive Oxygen Species (ROS) in times of Oxidative Stress. Oxidative stress arises from many wounds in the body, such as wounds in the skin, and can have significant impacts on the health of an individual. Even when receiving treatment for the skin wound, ROS can circulate from around the wound, be generated from an imbalance …

Synthesis And Characterization Of Multifunctional Cerium Oxide Containing Nanoparticles For Biomedical Applications, Ishaan Patel

Honors Undergraduate Theses

This study presents the synthesis and comprehensive characterization of a novel core-shell nanoparticle composed of a maghemite (γ-Fe₂O₃) core and a europium-doped cerium oxide (EuCNP) shell, developed for potential use in cancer theranostics. Using a co-precipitation method, Fe₂O₃–EuCNP core-shell nanoparticles were synthesized and compared against control samples of CNPs, EuCNPs, and Fe₂O₃. A variety of characterization techniques, including UV-Vis spectroscopy, fluorescence spectroscopy, TEM, XRD, XPS, DLS, TGA, and DSC confirmed the successful synthesis of core-shell architecture and europium doping. Moreover, Fe₂O₃–EuCNPs demonstrating strong colloidal …

Investigating The Role Of Prostasin In Angiogenesis: A Chorioallantoic Membrane Model Approach, Zaima Aline

Honors Undergraduate Theses

Prostasin, also known as PRSS8 or CAP1, is a glycosylphosphatidylinositol (GPI)-anchored extracellular serine protease involved in various physiological and pathophysiological processes. Prostasin expression is observed during key phases of trophoblast invasion and placental development, critical steps in embryo implantation in Rhesus monkeys. This suggests a role for prostasin in extracellular matrix remodeling and tissue invasion, both essential for a healthy pregnancy. Moreover, prostasin appears vital for development as studies in mice show that a germline knockout of the gene leads to significant placental defects and eventual embryonic death, highlighting its importance in vascular and structural development within the placenta.

Building …

Examining The Effect Of A High Fat Diet On The Expression Of Adipokines In A Murine Model Of Barrett's Esophagus, Saagar A. Shah

Honors Undergraduate Theses

Chronic acid reflux results in injury to the esophagus and the development of Barrett’s Esophagus (BE). BE elevates the lifetime risk for a patient to develop Esophageal Adenocarcinoma (EAC). Clinically, one of the main risk factors for BE and EAC is obesity, which alters the secretion of inflammatory cytokines by adipocytes, also referred to as adipokines. Conflicting reports have been made to the expression of adipokines and their receptors in the progression to esophageal cancer. Utilizing an inflammation-based mouse model for BE, we hypothesize that alterations in the expression of adipokines and their receptors favor an inflammatory environment associated with …

The Association Between Implicit Bias From Healthcare Providers And Postpartum Depression Among Black Women., Chelsea T. Costa

Honors Undergraduate Theses

Postpartum depression is one of the most common issues that women face after birth. Many different factors can contribute to the development of postpartum depression, including perinatal complications, prenatal depression, or social factors. One of the social factors that Black women, specifically, face leading to postpartum depression is discrimination. The purpose of this literature review is to identify research that focuses on whether implicit bias and discrimination by healthcare providers contributes to postpartum depression among Black women. A literature review was conducted using databases including CINHAL Plus Text, CINHAL ULTIMATE, Medline, and APA Psycinfo, with terms that included “healthcare provider* …

Exploring Patient-Provider Communication In Indian American Populations: A Scoping Review, Pranav S. Nadella

Honors Undergraduate Theses

Effective provider-patient communication directly influences patient satisfaction, treatment adherence, and health outcomes, yet the unique experiences of Indian Americans—one of the fastest-growing U.S. populations—remain underexplored in communication research. This scoping review, following Joanna Briggs Institute guidelines, systematically mapped the existing literature on provider-patient communication involving Indian Americans. Eleven studies met inclusion criteria, with data extracted on methods, populations, and seven coded aspects related to communication.

Findings revealed a narrow focus on first-generation immigrants and women, leaving men’s experiences and second-generation voices largely unexamined. Communication was shaped by language discordance, cultural stigma, family involvement, trust dynamics, and health literacy. No studies …

Cognitive Impairment And Depression In Hispanic And Non-Hispanic White Low-Income Older Adults A Cross-Sectional Study, Cecil Latta

Honors Undergraduate Theses

Hispanic older adults represent a growing population in the United States and may be disproportionately affected by cognitive impairment and depression. We theorize that cognitive impairment would be more prevalent in the older Hispanic community and would affect the levels of depression in both Hispanic and non-Hispanic Whites older adults. This cross-sectional study examined the association between cognitive impairment and depression in 157 older adults, including Hispanic (n = 91, 57.96%, age: M = 76.4, SD = 6.8) and non-Hispanic White (n = 66, 42.04%, age: M = 76.2, SD = 6.5). We used the Memory Impairment Screen to assess …

An Assessment Of U.S. Medical Students’ Self-Reported Knowledge, Attitudes, And Practices In Using Professional Medical Interpreters, Ezinne Okonkwo

Honors Undergraduate Theses

Professional medical interpreters interpret conversations between patients with limited English proficiency (LEP) and physicians. Given the important role professional medical interpreters play for LEP patients, current and future healthcare professionals would benefit from understanding their services and how to utilize them effectively. Research has explored how residents and physicians regard medical interpreters, but few studies have examined medical students' knowledge and perceptions about them. This cross-sectional study investigated medical students' knowledge, attitudes, and practices regarding professional medical interpreters. The sample was comprised of Florida medical students. Participants completed a one-time, quantitative online survey collecting information regarding their medical training, demographics, …

Addressing Barriers In The Primary Prevention Of Hypertension In Black People, Makalah Pierre Rn Bsn

Honors Undergraduate Theses

Hypertension is a significant health concern among minority groups, and the black population is most at risk (Abrahamowicz et al., 2023). The black population experience higher prevalence rates of hypertension compared to other racial groups and are more likely to experience hypertension-related problems, including cardiovascular disease (CVD) and chronic kidney disease (CKD).  This literature review explores various nursing interventions aimed at preventing hypertension within this population. In this review, the term “black people or persons” is a broad term used to describe both African Americans and people of Afro-Caribbean decent. This includes various backgrounds such as Haitian, Jamaican, or otherwise …

Healing Through Art: An Exploration Of Art History Influences On Contemporary Art Therapy For Practices In Oncology Care, Nicole Van

Honors Undergraduate Theses

Art therapy has emerged as a vital practice in oncology, offering patients a means of emotional expression and healing during their treatment journey. This project will explore how integrating art history into therapeutic settings, particularly through virtual classes, enhances the emotional well-being of cancer patients. By examining the impact of engaging with historical artworks, this research aims to illustrate how these artistic narratives can facilitate self-consciousness and foster flexibility in individuals facing significant health challenges. Research indicates that exposure to art can evoke emotion and promote psychological healing, serving as a therapeutic outlet for patients. This study will synthesize therapeutic …

Evaluating Coffee And Caffeine Intake In Adults With Cardiovascular Disease: A Comparative Literature Review, Adam Harrington

Honors Undergraduate Theses

Coffee is among the most commonly consumed beverages worldwide, and its bioactive components, including caffeine, affect the cardiovascular system through multiple physiological mechanisms. Patients with cardiovascular disease are typically advised to limit coffee and caffeine consumption because of potential cardiovascular harm, but emerging research challenges this recommendation. This review evaluates recent evidence regarding consumption of whole coffee, caffeine, or decaffeinated coffee in adults with established cardiovascular disease. Database searches conducted across three platforms for studies published after December 2021 yielded 360 records. Following screening against inclusion criteria, 11 studies were reviewed included in the final review. The studies showed variable …

2025-2026 Nursing Undergraduate Student Handbook, Morehead State University. Nursing Department.

Nursing Department Publications Archive

2025-2026 Undergraduate Student Handbook of the Department of Nursing at Morehead State University.

Effectiveness Of Mental Health First Aid As A Supportive Tactic On Resilience And Organisational Environment-Related Factors Among Hospital Nurses In The Wake Of Covid-19: The Search Continue, Nashwa Ibrahim

Nursing

Background: The implementation of Mental Health First Aid (MHFA) has been shown to effectively prevent long-term psychological effects of trauma. Additionally, it aids nurses in stabilising their emotional state and facilitates their practical recovery. Aim: To investigate the effect of MHFA on resilience capacity, organisational commitment, job insecurity and turnover among nurses working in the COVID-19 isolation units. Methods: Sixty nurses in COVID-19 isolation units participated in a quasi-experimental two-group, pre– post-test research. Nurses with low resilience capacity due to the COVID-19 crisis in Egypt completed a baseline survey. The study group employed MHFA strategies using the RAPID model. At …

Effect Of Implementing An Educational Program About Post Kidney Transplant Care On Critical Care Nurses' Knowledge, Marwa Abdo, Asmaa Ibrahim Aboseda

Nursing

Background: Critical care nurses (CCNs) play a pivotal role in post-kidney transplant care, necessitating a comprehensive understanding of transplantation procedures, complications, and patient management. So, any knowledge gaps among CCNs may impact the quality of care provide to kidney transplant program. Aim: This study aimed to assess the effect of implementing an educational program about post-kidney transplant care on critical care nurses’ knowledge. Methods: A quasi-experimental study was conducted among 50 critical care nurses. A structured educational program was implemented, and nurses’ knowledge was assessed pre- program, post- program, and three months follow-up. Data was collected using a kidney transplantation …

Comparison Of Treatment Outcome Of Occlusal Splints And Physiotherapy Regarding Their Effect On Posture: An In Vivo Pilot Study, Bouchra El Fassih, Amine El Zoghbi, Pascal El Braidy

International Arab Journal of Dentistry

Objectives: The primary objective of the research is to assess occlusal splints and physical exercise effect on posture. The secondary objective is to compare which treatment option has more positive feedback regarding posture adjustment.

Methods: twenty patients with temporomandibular disorders (TMD) were divided into two groups equally, one receiving occlusal splints as a treatment for TMD and the other group receiving physical therapy exercises. They underwent a clinical and postural examination at baseline, after 1 week, after 1 month and after 2 months of treatment. Postural stability was assessed using a force platform (SATEL). Subjects were evaluated in …