Medicine and Health Sciences Commons^™

Measuring Stigma In Pediatric Oncology: A Cross-Sectional Analysis Of Three Global Sites, Lara E Counts, Sara M Malone, Et Al.

2020-Current year OA Pubs

PURPOSE: Stigma contributes to fear and shame, resulting in delays in care-seeking behavior among individuals with cancer. As a social construct, stigma is affected by language, religion, culture, and local norms. This study explored pediatric cancer stigma at the time of diagnosis across diverse settings through the adaptation of two stigma measures.

METHODS: This study was conducted with adolescents and caregivers of children with osteosarcoma and retinoblastoma at three centers in Jordan, Guatemala, and Zimbabwe. The Stigma-related Social Problems (SSP) and the eight-item Stigma Scale for Chronic Illness (SSCI-8) measures were translated into Arabic, Spanish, and Shona and contextually adapted …

Structural Diversity Of Axonemes Across Mammalian Motile Cilia, Miguel Ricardo Leung, Chen Sun, Jianwei Zeng, Jacob R Anderson, Qingwei Niu, Wei Huang, Willem E M Noteborn, Alan Brown, Tzviya Zeev-Ben-Mordehai, Rui Zhang

2020-Current year OA Pubs

Reproduction, development and homeostasis depend on motile cilia, whose rhythmic beating is powered by a microtubule-based molecular machine called the axoneme. Although an atomic model of the axoneme is available for the alga Chlamydomonas reinhardtii

Abdominal Myosteatosis Measured With Computed Tomography Predicts Poor Outcomes In Patients With Glioblastoma, Farzaneh Rahmani, David H Ballard, Tammie L S Benzinger, Sonika Dahiya, John Evans, Sara Hosseinzadeh Kassani, Cyrus A Raji, Marilyn J Siegel, Joseph E Ippolito, Et Al.

2020-Current year OA Pubs

BACKGROUND: Alterations in cellular metabolism affect cancer survival and can manifest in metrics of body composition. We investigated the effects of various body composition metrics on survival in patients with glioblastoma (GBM).

METHODS: We retrospectively analyzed patients who had an abdominal and pelvic computed tomography (CT) scan performed within 1 month of diagnosis of GBM (178 participants, 102 males, 76 females, median age: 62.1 years). Volumetric body composition metrics were derived using automated CT segmentation of adipose tissue, skeletal muscle, and aortic calcification from L1 to L5. Univariable and multivariable Cox proportional hazards models were performed separately in males and …

Slc35a2 Gene Product Modulates Paramyxovirus Fusion Events During Infection, Yanling Yang, Yuchen Wang, Danielle E. Campbell, Heng-Wei Lee, Wandy Beatty, Leran Wang, Megan Baldridge, Carolina B. López

2020-Current year OA Pubs

Paramyxoviruses are significant human and animal pathogens that include mumps virus (MuV), Newcastle disease virus (NDV) and the murine parainfluenza virus Sendai (SeV). Despite their importance, few host factors implicated in paramyxovirus infection are known. Using a recombinant SeV expressing destabilized eGFP (rSeVCdseGFP) in a loss-of-function CRISPR screen, we identified the CMP-sialic acid transporter (CST) gene SLC35A1 and the UDP-galactose transporter (UGT) gene SLC35A2 as essential for paramyxovirus infection. As expected, SLC35A1 knockout (KO) cells showed drastic reduction in infections with SeV, NDV and MuV due to the lack of cell surface sialic acids receptors. However, SLC35A2 KO cells revealed …

Enhancing Engagement In Hiv Care Among Adolescents And Young Adults: A Focus On Phone-Based Navigation And Relationship Building To Address Barriers In Hiv Care, Harriet Fridah Adhiambo, Dorothy Imbuka Mangale, Elvin Geng, Et Al.

2020-Current year OA Pubs

Structural, psychological, and clinical barriers to HIV care engagement among adolescents and young adults living with HIV (AYAH) persist globally despite gains in HIV epidemic control. Phone-based peer navigation may provide critical peer support, increase delivery flexibility, and require fewer resources. Prior studies show that phone-based navigation and automated text messaging interventions improve HIV care engagement, adherence, and retention among AYAH. However, little is known about AYAH experiences utilizing electronic phone-based peer navigation and automated text messaging (E-NAV). We assessed the experiences of AYAH receiving phone-based peer navigation to address barriers to HIV care engagement and viral suppression. We purposefully …

Poor Sleep Is Common In Treatment-Resistant Late-Life Depression And Associated With Poorer Antidepressant Response: Findings From The Optimum Clinical Trial, Michael S B Mak, Marie Anne Gebara, Eric J Lenze, Daniel M Blumberger, Patrick J Brown, Pilar Cristancho, Alastair J Flint, Jordan F Karp, Helen Lavretsky, J Philip Miller, Charles F Reynolds 3rd, Steven P Roose, Benoit H Mulsant, Sarah T Stahl

2020-Current year OA Pubs

BACKGROUND: Adults with treatment-resistant late-life depression (TRLLD) have high rates of sleep problems; however, little is known about the occurrence and change in sleep during pharmacotherapy of TRLLD. This analysis examined: (1) the occurrence of insufficient sleep among adults with TRLLD; (2) how sleep changed during pharmacotherapy; and (3) whether treatment outcomes differed among participants with persistent insufficient sleep, worsened sleep, improved sleep, or persistent sufficient sleep.

METHODS: Secondary analysis of data from 634 participants age 60+ years in the OPTIMUM clinical trial for TRLLD. Sleep was assessed using the sleep item from the Montgomery-Asberg Depression Rating Scale at the …

Molecular Regulation And Therapeutic Targeting Of Vldl Production In Cardiometabolic Disease, Kendall H Burks, Nathan O Stitziel, Nicholas O Davidson

2020-Current year OA Pubs

There exists a complex relationship between steatotic liver disease (SLD) and atherosclerotic cardiovascular disease (CVD). CVD is a leading cause of morbidity and mortality among individuals with SLD, particularly those with metabolic dysfunction-associated SLD (MASLD), a significant proportion of whom also exhibit features of insulin resistance. Recent evidence supports an expanded role of very low-density lipoprotein (VLDL) in the pathogenesis of CVD in patients, both with and without associated metabolic dysfunction. VLDL represents the major vehicle for exporting neutral lipid from hepatocytes, with each particle containing one molecule of apolipoproteinB100 (APOB100). VLDL production becomes dysregulated under conditions characteristic of MASLD …

Reliability Of Wrist Arthroscopy In The Diagnosis And Treatment Of Triangular Fibrocartilage Complex Tears, Elizabeth A Graesser, Lindley B Wall, Sanjeev Kakar, Jeffrey Yao, Marc J Richard, R Glenn Gaston, Charles A Goldfarb

2020-Current year OA Pubs

PURPOSE: Wrist arthroscopy is considered the gold standard for diagnosis of intra-articular wrist conditions including triangular fibrocartilage complex (TFCC) tears; however, the ability to reliably diagnose TFCC pathology during wrist arthroscopy is unclear. The purpose of this study was to assess the reliability of the diagnosis of TFCC tears on wrist arthroscopy videos.

METHODS: Five hand surgeons reviewed 43 cases on a secure web-based platform at two time points separated by 4-6 weeks. Each case included a deidentified clinical vignette and wrist radiographs with ulnar variance measurements and an arthroscopy video of ulnar wrist pathology, averaging 42 seconds. Surgeons were …

Advanced Nanocomposite-Based Electrochemical Sensor For Ultra-Sensitive Dopamine Detection In Physiological Fluids, Megha Shinde, Gymama Slaughter

Center for Bioelectronics Publications

This study presents a novel point-of-care electrochemical sensor for dopamine (DA) detection, featuring a flexible laser-induced graphene (LIG) modified with a unique nanocomposite comprising Nb₄C₃T_x MXene, polypyrrole (PPy), and iron nanoparticles (FeNPs). The LIG-Nb₄C₃T_x MXene-PPy-FeNPs is characterized by scanning electron microscopy to confirm the successful surface modification. The electrochemical performance of the fabricated sensor via cyclic voltammetry showed significant electrochemical activity upon Nb₄C₃T_x MXene-PPy-FeNPs nanocomposite modification of the LIG surface with an increased peak anodic current (Ipa) from 43 μA to 104 μA. The sensor …

Electrochemical Detection Of Prostate Cancer—Associated Mirna-141 Using A Low-Cost Disposable Biosensor, Alexander Hunt, Gymama Slaughter

Center for Bioelectronics Publications

Prostate cancer is the second leading cause of cancer-related deaths among men in the United States. The early detection of aggressive forms is critical. Current diagnostic methods, including PSA testing and biopsies, are invasive and often yield false results. MicroRNA-141 (miRNA-141) has emerged as a promising non-invasive biomarker due to its elevated levels in the urine of patients with metastatic prostate cancer. Here, a low-cost, paper-based electrochemical biosensor for the sensitive detection of miRNA-141 in synthetic urine is reported. The device employs inkjet-printed gold electrodes on photopaper, functionalized with thiolated single-stranded DNA-141 capture probes for specific target recognition. The biosensor …

Gold Nanoparticle-Enhanced Molecularly Imprinted Polymer Electrode For Non-Enzymatic Lactate Sensing, Christopher Animashaun, Abdellatif Ait Lahcen, Gymama Slaughter

Center for Bioelectronics Publications

We are reporting the development of a high-performance, non-enzymatic electrochemical biosensor for selective lactate detection, integrating laser-induced graphene (LIG), gold nanoparticles (AuNPs), and a molecularly imprinted polymer (MIP) synthesized from poly(3,4-ethylenedioxythiophene) (PEDOT). The LIG electrode offers a highly porous, conductive scaffold, while electrodeposited AuNPs enhance catalytic activity and signal amplification. The PEDOT-based MIP layer, electropolymerized via cyclic voltammetry, imparts molecular specificity by creating lactate-specific binding sites. Cyclic voltammetry confirmed successful molecular imprinting and enhanced interfacial electron transfer. The resulting LIG/AuNPs/MIP biosensor demonstrated a wide linear detection range from 0.1 µM to 2500 µM, with a sensitivity of 22.42 µA/log(µM) and …

Electrochemical And Nanomaterial Based Strategies For Nonenzymatic Glucose Detection: A Review, Reagan Aviha, Gymama Slaughter

Center for Bioelectronics Publications

Electrochemical glucose sensing technologies have undergone significant evolution, with continual advancements aimed at improving sensitivity, selectivity, and user convenience. This review systematically explores the development of emerging nonenzymatic glucose sensor designs. Nonenzymatic sensors are critically evaluated for their ability to overcome enzymatic limitations, leveraging novel materials and catalytic mechanisms. Additionally, the emergence of smartphone-integrated glucose monitoring systems is highlighted as the fifth generation, representing a paradigm shift toward personalized, real-time healthcare management. Emphasis is placed on the strategies employed to reduce the working electrode potential and enhance analytical performance. Key analytical metrics and real-sample applicability are evaluated, and persistent challenges …

Molecular Imprinting And Nanomaterial Synergy For Lactate Detection, Christopher Animashaun, Gymama Slaughter

Center for Bioelectronics Publications

Molecularly imprinted polymer (MIP)-based electrochemical sensors have emerged as promising non-enzymatic platforms for the selective and stable detection of clinically and environmentally relevant biomarkers. This review provides a critical, comprehensive analysis of recent advances in MIP-based lactate sensing, with particular emphasis on hybrid systems that integrate conductive nanomaterials including gold and silver nanoparticles, laser-induced graphene, and reduced graphene oxide. These synergistic combinations leverage enhanced surface area, electrical conductivity, and molecular recognition to improve sensor sensitivity, selectivity, and long-term operational stability. Key fabrication strategies, such as electropolymerization, green nanomaterial synthesis, and surface imprinting, are critically examined for their roles in optimizing …

Barriers To Postpartum Depression Treatment: Availability And Accessibility Of Maternal Behavioral Health-Inclusive Support Groups For Low-Income Populations, Radhika S. Venkatesan

Honors Undergraduate Theses

The maternal health crisis is a prevalent and concerning issue in the United States. The lack of efficient availability and accessibility to health care services plays a significant role in augmenting this problem. One health care service that is often understudied is support groups, for prevalent issues like postpartum depression. Considering the socioeconomic burdens of low-income mothers, this paper analyzed the accessibility and availability of maternal health support groups across counties in Florida, with varying amounts of individuals below the federal poverty level (%BPL). Essentially, Florida counties were divided into one of four categories depending on their %BPL. A Fisher’s …

Prospective Evaluation Of Plasma Proteins In Relation To Surgical Endometriosis Diagnosis In The Nurses’ Health Study Ii, Naoko Sasamoto, Long H. Ngo, Allison F. Vitonis, Simon T. Dillon, Maryam Aziz, Amy Shafrir, Stacey A. Missmer, Towia A. Libermann, Kathryn L Terry

Health Sciences Faculty Publications

No abstract provided.

Clinician Perspectives On Incorporating Physical Activity And Sleep Prescriptions Using Ehealth For Youth With Comorbid Psychiatric Disorders: Qualitative Focus Group Study, Alyssa M. Button, James Slavet, Amanda E. Staiano, April Bowling

Health Sciences Faculty Publications

Background: Physical activity and sleep prescriptions are indicated for the treatment of psychiatric disorders among youth. However, there is limited clinical adoption of these practices. Exergaming (ie, games that require physical activity) is a feasible intervention to promote physical activity and sleep hygiene and is appealing to youth given their interest in video gaming. Integrating exergaming prescriptions into clinical mental health practices may offer an opportunity to expand access to these interventions, yet pragmatic considerations for adopting these programs are poorly understood.

Objective: This study aimed to gain feedback from practicing clinicians on adopting GamerFit, an app-based intervention that incorporates …

Benefits Of Early Intervention With A Certified Lymphedema Therapist For Management Of Radiation Fibrosis Syndrome (Rfs) And Axillary Web Syndrome (Aws) In Breast Cancer Patients, June Leary, June Leary

Capstone Showcase

All breast cancer treatment leads to soft tissue changes in the treated quadrant. While these changes are chronic, they are also identifiable and manageable with care from an appropriate provider. Scarring, lymphedema, radiation fibrosis syndrome (RFS), and axillary web syndrome (AWS) may all be part of the post-treatment soft tissue changes for a breast cancer survivor.

Familiarity with the likely presentation and lifelong management of a patient’s specific symptom burden is crucial. While any physical therapist can rehabilitate the neuropathies, shoulder pain, postural dysfunction, or other numerous orthopedic issues that may occur, there is an acknowledged deficit in the treatment …

Myrtillin As A Promising Immunomodulator: Molecular Modeling And Pharmacokinetic Evaluation, Adolat Manakbayeva, Timur Kerimov, I D. Ershov, E. I. Anarkulova, Pavel Alexyuk, Y Moldakhanov, Ahdrey P. Bogoyavlenskiy, Vyacheslav Dushenkov

Publications and Research

Myrtillin, an anthocyanin found in blueberry fruits, is known for its antioxidant and potentially immunomodulatory properties. In this study, molecular docking was used to evaluate its interactions with a wide panel of immune-related proteins, including pro-inflammatory cytokines (TNF-α, IL-6, IL-17), antiinflammatory mediators (IL-4, IL-10), and signaling pathway proteins (1NFK, p52/RelB). The in silico results were supported by interaction analysis, and an ADMET analysis was conducted to assess the pharmacokinetic and toxicological profile. The findings confirm the promise of Myrtillin as a natural modulator of inflammatory responses.

Flipped Classroom Versus Lecture: A Quasi-Experimental Study Evaluating The Performance Of Dental Students.”, Manal Elhijazi, Ihsane Benyahya

Health Sciences

Background: The flipped classroom is an active pedagogical modality that improves learning, autonomy and critical thinking. This work aims to evaluate the impact of the flipped classroom on student performance compared to the lecture in a biomaterials course.

Material and methods:Second-year dental students were invited to participate voluntarily in this quasi-experimental study .Thus, they were divided into two groups: one group benefited́ from the flipped classroom while the control group attended the lecture. At the end of a formative evaluation for both groups, their average grades were compared using Student's test (significance threshold set at p

Results : …

Effect Of Nonsurgical Periodontal Therapy On Oxidative Stress Biomarkers And Glycemic Control In Type 2 Diabetic Patients, Eman Taha, Eman Shawki, Fady Kyrillos, Mohamed A. Al-Shahat

Mansoura Journal of Dentistry

Objective Reactive oxygen species are increasingly being linked to the pathophysiology of periodontal tissue damage. The one of the sensitive significant markers used for assessing oxidative damage in several conditions is 8-hydroxy-deoxyguanosine (8- OHdG). The current study aims to estimate the effects of non-surgical treatment for periodontal disease on the concentrations of 8-OHdG in plasma and saliva as oxidative stress biomarker, as well as its impact on glycemic control in individuals with type 2 diabetes (T2D) and periodontitis. Subjects and Methods The study involved 50 nonsmoking patients. 20 T2D patients with periodontitis. 20 nondiabetic with periodontitis. 10 healthy non-diabetic without …

A Quantitative Study Comparing The Effects Of Physical And Digital Mandala Coloring On Anxiety In High School Students, Amy Bainton

Art Therapy | Master's Theses

Through the frameworks of Solution-Focused School Counseling (SFSC) and art therapy, this quantitative research paper compared the potential effects of using a physical versus a digital mandala coloring page with high school students experiencing test anxiety before a final exam. Participants took part in one of two experimental tasks before taking their exam, where they either used colored pencils to color a preset mandala or used a cellphone-based website to color in a mandala digitally. Participants completed a brief pretest-posttest State-Trait Anxiety Inventory (STAI) and answered an independent questionnaire to further understand their experience after artmaking. Data results were analyzed …

Mixed Methods Study On The Impact Of Coloring Mandalas On Emotional Regulation, Mindfulness, And Attachment Style In Adults, Rachel N. Faas

Art Therapy | Master's Theses

Abstract
This mixed methods study investigates the impact of coloring pre-drawn mandalas on adult emotional regulation, mindfulness, and state attachment style. Drawing from Attachment Theory and Art Therapy frameworks, the research evaluates whether adult coloring interventions—specifically structured mandala designs—can serve as accessible tools for improving psychological well-being. A sample of adult participants engaged in a mandala coloring intervention and completed pre- and post-assessments measuring emotional regulation, mindfulness, and attachment style, including qualitative interviews to capture subjective experiences. Results suggest that mandala coloring may promote increased mindfulness and adaptive emotional regulation strategies, with preliminary evidence indicating shifts toward more secure attachment …

Altered Book Making With Siblings Of Adults With Schizophrenia: A Mixed Methods Approach, Anna-Marie M. Vargas

Art Therapy | Master's Theses

Schizophrenia is a severe mental illness that affects the entire family unit. Due to deinstitutionalization, families are often left to care for their loved ones the best they can without the structured support offered by long-term hospitalization. As parents age and become less able to care for adult children with schizophrenia, the task of ongoing support in various capacities falls to the next of kin, most often, to siblings. There is limited research on the experiences of siblings of adults with schizophrenia, and to date, there have not been any published studies with this population in the field of art …

Creating A Neonatal Intensive Care Unit Evidence Based Evaluation Protocol, Mary Redlin

Occupational Therapy Capstones

Background: Neonatal Intensive Care Units (NICU) in the United States admit approximately 300,000 infants annually (Valencia et al., 2023). Upon admission, neonatal occupational therapists assess a range of factors, including neurobehavioral, neuromotor, musculoskeletal, and sensory systems, as well as family/caregiver interactions and activities of daily living (Craig et al., 2018). This comprehensive evaluation underscores the need for effective assessment tools, efficient protocols, and adequate support for therapists. However, practitioners often face challenges that impact the quality of care, such as limited resources, lack of specialized training, and inconsistent organizational standards (Kaur et al., 2021). Occupational therapy has emerged as a …

Promoting Wellness In Community-Dwelling Older Adults: An Occupational Therapy Approach Guided By The Eight Dimensions Of Wellness, Mckenzie Ulrich

Occupational Therapy Capstones

Background: Wellness is a process where an individual intentionally makes choices to support a satisfying lifestyle and is aware of their choices (Swarbrick & Yudof, 2015). In the United States, unhealthy lifestyle choices and the high prevalence of chronic conditions negatively influence one’s health, wellness, and quality of life (Li et al., 2018). Additionally, age-related changes can negatively influence one’s overall well-being. Examples of age-related changes may include changes in strength, mobility, coordination, balance, gait, and cognitive functioning (Bello-Haas et al., 2018a; Bello-Haas et al., 2018b; Judge & Dawson, 2018). Occupational therapy's role in health promotion and prevention includes promoting …

Occupational Participation Through Harm Reduction, Allie Reiffenberger

Occupational Therapy Capstones

Purpose: Individuals who have experienced homelessness face higher risks of physical disabilities, mental illnesses, and substance use disorders (SUD), which often co-occur, compared to the general population (Mosel, 2024; Parker & Scaffa, 2020; SAMHSA, 2023a). Due to past experiences and unmanaged chronic conditions, substance use, and negative health behaviors are common. The high prevalence of SUD, mental illness, and chronic health conditions in this group severely affects their ability to engage in daily activities, influencing overall health and well-being (Marshall et al., 2020a). While complete abstinence is often deemed ideal, it can be unrealistic for this population. Harm reduction seeks …

Accessibility Of Higher Education: Supporting Student Self-Advocacy, Morgan Diane Halliday

Occupational Therapy Capstones

As of the 2020-2021 academic year, 1 in 5 undergraduate students reported having a disability (National Center for Education Statistics, n.d.). College students with disabilities (CSWD) face social and physical environmental barriers to higher education due to exclusive policies, procedures, and designs. In turn, occupational engagement is decreased, inhibiting participation in education. A college education can support career opportunities, financial stability, and personal development (Plotner & May, 2019). Therefore, it is essential that CSWD have equitable access. Despite efforts from college campuses to become more accessible, gaps remain that require CSWD to be self-advocates. The purpose of this project was …

A Guide To Occupational Therapy Intervention Planning For Individuals With Migraines In Rural Communities, Angelina M. Caron

Occupational Therapy Capstones

One in ten individuals in the world experience migraines (Amari et al., 2022). Migraines are a debilitating condition that presents with symptoms of intense head pain, aura, and nausea (American Migraine Foundation, 2018; Mayo Clinic, 2023). These symptoms have a global effect on an individual’s life and affect the meaningful and necessary tasks they do each day including work, school, family and social life, and their emotional health and cognitive functioning (Buse et al., 2019; Estave et al., 2021). Occupational therapy (OT) can be used with individuals with migraine by addressing factors such as routines, migraine self-management, cognitive strategies, and …

Coming To Your Senses: A Guide For Sensory Considerations In Higher Education, Aspen D. Delano

Occupational Therapy Capstones

Background: Sensory stimuli bombard humans at every point during their day. Senses are the avenue through which humanity interacts with its world. Individuals have varying thresholds of sensory stimuli. When people face more stimuli than they can cope with, they struggle to interact with the world around them. This can pose a significant challenge for graduate-level college students due to the already strenuous mental load required for formal education. The association between sensory processing and stress has strengthened in recent years, with individuals reporting a positive feedback loop between these constructs (Harrold et al., 2024). Stress leads to greater sensory …

A Happy Medium?: Using Image Generators To Explore Solution-Focused Art Therapy’S Miracle Question, Daniel A. Hernried

Art Therapy | Master's Theses

This mixed methods, randomized, single-session study tested whether integrating text-to-image generations into Solution-Focused Brief Art Therapy alters therapeutic rapport and short-term outcomes relative to traditional artmaking materials. Participants were assigned by coin flip to create using either a text-to-image generator or convention media (23 per group), completing immediate and three-day follow-ups. Alliance was measured using DREAM (Dimensions of Regard, Empathy, and Authenticity Metric), and problems were rated pre/post; groups did not differ significantly on DREAM total or facets, and both modalities produced reliable pre-to-post reductions in problem severity. At the same time, process differences were pronounced: the AI condition showed …