Medicine and Health Sciences Commons^™

Empowering Birth: Comparing Nurse-Led Holistic And Pharmacologic Pain Relief Approaches​, Jessica C. Moore

Nursing | Student Research Posters

Childbirth is often described as one of the most meaningful experiences in a woman’s life. During this time, effective pain management is essential not only for reducing discomfort, but also for improving maternal satisfaction and minimizing unnecessary obstetric interventions. While childbirth is frequently approached as a purely physical process, it is inherently holistic, influenced by cultural, social, psychological, and emotional factors.

Growing evidence highlights the value of incorporating and educating patients and providers on non-pharmacologic strategies such as breathing techniques, massage, aromatherapy, hydrotherapy, positioning ,ambulation, and continuous emotional support.

For example, a study in Sweden that found that a group …

Developing A Nursing Early-Intervention Bundle To Decrease The Prevalence Of Post-Intensive Care Syndrome, Aneesha Biju

Nursing | Student Research Posters

Post-intensive care syndrome (PICS) has become an increasingly recognized challenge in critical care as more patients survive prolonged mechanical ventilation and lengthy ICU stays. Although lifesaving interventions support recovery from the primary illness, many patients develop new or worsened physical, cognitive, or psychological impairments after discharge. These complications often limit independence, slow recovery, and create long-term burdens for both patients and families. Research shows that early, consistent nursing interventions, such as delirium prevention, early mobility, mental health support, and family communication, can reduce the risk of PICS. The absence of a unified and standardized approach results in inconsistent practices and …

The Effects Of Strong Social And Parental Support Compared To Low Or Absent Support In Lgbtqia+ Youth Mental Health, Kassandra Bautista

Nursing | Student Research Posters

Throughout history, sexual and gender minorities have faced a range of emotional and psychological challenges shaped by their unique experiences and interactions with society, family, and peers. According to the American Psychiatric Association (APA), homosexuality was classified as a sociopathic personality disturbance in the first edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-I) in 1952, and it remained listed as a mental disorder until it was removed in 1973. Individuals that identified as lesbian, gay, bisexual, transgender, queer, or other identities within the LGBTQIA+ community were historically seen as abnormal and were often subjected to ethically problematic …

Comparing Human Milk-Derived Vs Bovine-Derived Fortifiers In Formula-Fed Preterm Infants On The Incidence Of Necrotizing Enterocolitis, Maya C. Kern

Nursing | Student Research Posters

Necrotizing enterocolitis (NEC) is one of the leading causes of death in infants < 32 weeks gestation and/or < 1500g. Human breast milk lowers NEC rates through immunologic, microbial, and gut-protective mechanisms. When maternal or donor milk is unavailable, infants require formula with fortification but the safest type of fortifiers remains unclear. Bovine-derived fortifiers may increase gut inflammation; human milk-derived fortifiers may offer more protection. Limited research exists comparing these fortifiers when infants are exclusively formula fed. Determining if human milk-derived fortifiers still reduce NEC risk could influence NICU feeding guidelines and improve outcomes.

Developing An Educational Session And Epic-Based Tools To Help Nurses Provide Culturally Sensitive Care To Their Muslim Patients, Laila Albutmeh

Nursing | Student Research Posters

Islam is currently the fastest growing religion in the world. The chances of nurses getting Muslim patients are on a rise. Islam is not just a religion but a way of life that shapes/guides every aspect of human experience. With religion being such an important part in a Muslim's life, they need nurses to be able to provide them culturally sensitive care. Nurses can do this if they are equipped with the right knowledge and tools. Implementing educational resources on how to provide culturally sensitive care to Muslim patients for nurses to use will help them be able to provide …

The Impact Of Nurse-Led Distraction Techniques On Pain And Anxiety During Cancer Treatment In Pediatric Oncology Patients: Examining Virtual Reality And Play Therapy, Alexis Abalos

Nursing | Student Research Posters

Children undergoing cancer treatment often experience pain and anxiety during procedures such as port access or peripheral catheterization. Nurse-led distraction techniques, including virtual reality and play therapy, have emerged as promising non-pharmacologic interventions to reduce pain and anxiety in pediatric oncology patients. Existing data from primary and secondary research articles reveal the effectiveness of virtual reality and play therapy on reducing pain, anxiety, and psychosocial distress in pediatric oncology patients receiving cancer treatment. This study proposes a quasi-experimental design involving 90 pediatric oncology patients aged 6–12 years diagnosed with leukemia. Participants will be placed in a nurse-led VR distraction, play …

Effectiveness Of Post-Discharge Interventions Following Psychiatric Hospitalization On Readmissions And Suicide Prevention Among Adolescents, Maria Paz Eladia Posadas

Nursing | Student Research Posters

Background: Suicide is a pervasive and far-reaching issue. Psychiatric hospitalization is often used as an intervention for individuals, including adolescents, experiencing suicidal ideation and/or behavior. However, post-discharge care may lack structure or clearly defined follow-up services, which can result in rehospitalizations and increased suicidality. Objective: The goal of the proposed research study is to investigate how implementation of peer support groups for adolescents following psychiatric hospitalization can assist in reducing readmissions and mitigating suicide risk. This can also help shape strategies for managing care after discharge. Method: The proposed research study utilizes a quantitative quasi-experimental design to determine the efficacy …

Paternal Involvement And Bonding In Neonatal Intensive Care Unit: Evaluating Daily Caregiving, Emotional Well-Being, And Father-Infant Connection, Ava G. Kinyon

Nursing | Student Research Posters

Background: Premature birth and serious neonatal conditions frequently require infants to obtain care in the NICU, producing psychological and emotional obstacles for families. Despite the fact that skin-to-skin contact has been extensively researched for its strengths in encouraging stability and bonding, there persists restricted importance and understanding on paternal participation in routine caregiving tasks such as feeding, diapering, temperature checks, and swaddling. Purpose: This study aims to evaluate paternal participation in daily NICU caregiving tasks to address gaps in comprehending how these experiences impact bonding and emotional well-being among fathers of hospitalized infants. Methods: This study will …

Early Changes In Inflammation-Related Proteins In The Cerebrospinal Fluid And Plasma Of Patients With Aneurysmal Subarachnoid Hemorrhage, David J. Braun, Kevin W. Hatton, Justin F. Fraser, Robert M. Flight, Hunter N. B. Moseley, Caleb S. Bailey, Josh M. Morganti, Bingqing Zhang, Ishara S. Ariyapala, Tae K. Kim, Linda J. Van Eldik

Sanders-Brown Center on Aging Faculty Publications

Background

Aneurysmal subarachnoid hemorrhage (aSAH) is a relatively uncommon but high mortality form of stroke that can result in long-lasting disability. A better understanding of key neuroinflammatory changes during the early phase (< 72 h) may provide potential avenues of treatment.

Methods

In an attempt to understand these early changes, we recruited 7 aSAH patients for profiling of longitudinal plasma and cerebrospinal fluid (CSF) proteins at up to 72 h post injury. We additionally compared this to control plasma obtained previously from healthy elderly volunteers. Using the Alamar Biosciences NULISAseq platform, we obtained a comprehensive picture of early peripheral and central inflammatory changes after injury.

Results

This study …

Nicorandil Treatment Improves Survival And Spatial Learning In Aged Granulin Knockout Mice, Dana M. Niedowicz, Wang-Xia Wang, Paresh Prajapati, Yu Zhong, Shuling X. Fister, Colin B. Rogers, Pradoldej Sompol, David K. Powell, Indumati Patel, Christopher M. Norris, Kathryn E. Saatman, Peter T. Nelson

Sanders-Brown Center on Aging Faculty Publications

Mutations in the human granulin (GRN) gene are associated with multiple diseases, including dementia disorders such as frontotemporal dementia (FTD) and limbic-predominant age-related TDP-43 encephalopathy (LATE). We studied a Grn knockout (Grn-KO) mouse model in order to evaluate a potential therapeutic strategy for these diseases using nicorandil, a commercially available agonist for the ABCC9/Abcc9-encoded regulatory subunit of the “K⁺ATP” channel that is well-tolerated in humans. Aged (13 months) Grn-KO and wild-type (WT) mice were treated as controls or with nicorandil (15 mg/kg/day) in drinking water for 7 months, then tested for neurobehavioral …

Gait Variability As A Marker Of White Matter Integrity In Individuals With Down Syndrome, Elizabeth M. Leach, David K. Powell, Amanda C. Glueck, Elizabeth Head, Moaz W. Ibrahim, Amelia J. Anderson-Mooney, Kathryn L. Van Pelt, Jordan P. Harp, Frederick A. Schmitt, Ahmed A. Bahrani

Sanders-Brown Center on Aging Faculty Publications

Introduction: Individuals with Down syndrome (DS) face a significant risk of neurodegeneration, and gait variability may serve as a clinical biomarker of neurological health. This longitudinal parent substudy aimed to explore relationships between gait, white matter (WM) integrity, and cognitive function in DS.

Methods: The associations were investigated between magnetic resonance imaging diffusion tensor imaging (DTI), cognition, and self-paced gait data from 22 DS participants (mean age ± SD 37 ± 7.5 years).

Results: DTI measures, such as lower fractional anisotropy (FA) and higher mean diffusivity, were correlated with greater step time variability but not normalized velocities. Lower cognitive scores …

Disrupted Calcium Dynamics In Reactive Astrocytes Occur With End Feet–Arteriole Decoupling In An Amyloid Mouse Model Of Alzheimer’S Disease, Blaine Weiss, John C. Gant, Ruei-Lung Lin, Jenna L. Gollihue, Colin B. Rogers, Susan D. Kraner, Edmund B. Rucker, Yuriko Katsumata, Yang Jiang, Peter T. Nelson, Donna M. Wilcock, Pradoldej Sompol, Olivier Thibault, Christopher M. Norris

Sanders-Brown Center on Aging Faculty Publications

While cerebrovascular dysfunction and reactive astrocytosis are extensively characterized hallmarks of Alzheimer's disease (AD) and related dementias, the dynamic relationship between reactive astrocytes and cerebral vessels remains poorly understood. Here, we used jGCaMP8f and two-photon microscopy to investigate calcium signaling in multiple astrocyte subcompartments, concurrent with changes in cerebral arteriole activity, in fully awake 7- to 8-month-old male and female 5xFAD mice, a model for AD-like pathology, and wild-type (WT) littermates. In the absence of movement, spontaneous calcium transients in barrel cortex occurred more frequently in astrocyte somata, processes, and perivascular regions of 5xFAD mice. However, evoked arteriole dilations (in …

Knee Health Is A Major Determinant Of Mobility Across The Healthspan, Brandon M. Peoples, Kenneth Harrison, Michael A. Samaan, Christopher B. Mobley, David T. Redden, Jaimie A. Roper

Kinesiology and Health Promotion Faculty Publications

Knee health constitutes a pivotal determinant of locomotor function and overall mobility throughout the healthspan. Impairments in knee function lead to a series of biomechanical and physiological alterations that pose substantial public health challenges and economic burdens worldwide. This review synthesizes evidence that delineates the complex and multifaceted relationship between knee health and mobility, emphasizing the interplay across various domains in adult populations. Knee health is conceptualized as a dynamic, interconnected system whereby structural integrity, neuromuscular mechanisms, biomechanical adaptations, and functional mobility are intricately interrelated through cascades of mechanistic processes operating across different temporal stages. A comprehensive understanding of these …

The Impacts Of Dietary And Educational Intervention In Addressing Adult Obesity In The Mexican Population, Matthew C. Servin

CMC Senior Theses

Mexico’s obesity epidemic has been an ongoing issue for the past few decades, with multiple studies attributing this to the disparities in accessing healthy food and health education. Designing a solution to Mexico’s adult obesity crisis will focus on studying the effects of an intervention plan that addresses these obesogenic factors. This proposed study will assess how a token system and health education sessions may impact the risk of obesity in the adult Mexican population. This study also will consider any limitations that arise when only one of the two intervention methods are used. As these interventions are implemented over …

Impact Of Hiv-2 Rod9 Vpx Mutations On Samhd1 Degradation And Vpx Nuclear Trafficking, Tolulope R. Oladimeji

All Graduate Theses, Dissertations, and Other Capstone Projects

Human Immunodeficiency Virus (HIV) is a leading cause of death in many parts of the world. HIV-2, endemic to West Africa, has infected over 2 million people globally. A key difference between HIV-2 and the more widespread HIV-1 is the HIV-2 protein Vpx, which facilitates infection in non-dividing cells by targeting SAMHD1, a host innate immune protein, for proteasomal degradation. This research aims to identify specific amino acid residues in HIV-2 ROD9 Vpx that are essential for mediating SAMHD1 degradation by the proteosome. I hypothesize that amino acid residues located in the C-terminal region of Vpx play a critical role …

Effective Measurement-Based Care For Depression Within Va Health Systems: A Quality Improvement Initiative, Amie L. Doyle

DNP Scholarly Projects

Background: Depression is highly common among U.S. veterans, surpassing civilian rates. Measurement-Based Care (MBC), including the Patient Health Questionnaire-9 (PHQ-9), facilitates systematic symptom monitoring and treatment enhancement. At Manchester VA Medical Center (VAMC), PHQ-9 completion in primary care was low (18.93% in May 2025) due to workflow inefficiencies, provider workload, and dependence on Mental Health Service Line (MHSL) referrals.

Local Problem: Underutilization of the PHQ-9 in primary care hampers early detection and effective treatment of depression among veterans.

Methods: Four primary care teams received training on using the Behavioral Health Laboratory (BHL) software, which facilitates pre-visit electronic completion of the …

Improving Transitions In Care: The Post-Discharge Follow-Up Process For Va Hospitalizations, Kristina Huntoon

DNP Scholarly Projects

BACKGROUND: Transitions in care from hospitalization to home are a high-risk period for patients. Without care coordination during these transitions in care, patients are left trying to manage their care without any support. The VA has a mandated two-day post-discharge contact process that requires a member of the patient’s primary care team to contact the patient within two business days of a VA discharge.

METHODS: The Plan-Do-Study-Act method of quality improvement was used for this project. Baseline assessment included review of patient medical records for 15 months before the intervention, which included 27 discharges from unit 78C. The patient medical …

Dean's Report- Winter-Spring 2025, Marina K. Holz

GSBMS Dean’s Report

No abstract provided.

Chronic Alcohol Consumption Induces Phenotypic And Functional Alterations Consistent With A Hyper-Inflammatory State In Peripheral Blood Mononuclear Cell-Derived Microglia In A Rhesus Macaque Model, Hami Hemati, Madison B. Blanton, Heather E. True, Jude Koura, Rupak Khadka, Kathleen A. Grant, Ilhem Messaoudi

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Alcohol-induced dysregulation of microglial activity is associated with neuroinflammation, cognitive decline, heightened risk for neurodegenerative diseases, alcohol dependence, and escalation of alcohol drinking. Given the challenge of longitudinally sampling primary microglia, we optimized an in vitro method to differentiate peripheral blood mononuclear cells (PBMC) from rhesus macaque (RM) into induced microglia-like cells (RM-iMGLs). The RM-iMGLs displayed transcriptional profiles distinct from monocyte progenitors and closely resembling primary microglia. Notably, morphological features showed that differentiated RM-iMGLs derived from subjects with chronic alcohol consumption (CAC), while bigger, exhibited a bipolar-like morphology. Additionally, dysregulation in key inflammatory and regulatory markers, along with increased baseline …

Perceived Obligations Of Older Partners In Living-Apart-Together Relationships, Allison M. Martin, Timothy S. Killian

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

Older and middle-aged adults are increasingly in Living-Apart-Together (LAT) relationships characterized by committed romantic relationships without marriage and cohabitation. Because of assumptions that older adults will receive family caregiving as they grow older and need caregiving, it is not clear how people are likely to perceive obligations to provide caregiving assistance. As adults move into old age and incidence rates of Alzheimer’s Disease or Related Dementia (ADRD) increase, questions about the availability of family members to provide needed assistance are complicated by LAT relationships. The purpose of this study was to examine perceived obligations to provide assistance to older adults …

Adapting A Mobile Health Intervention To Improve Prep Adherence Among Young Black Msm In Fulton County, Georgia, Kassidy Maust

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Young Black men who have sex with men (YBMSM) in the southern United States, particularly in Fulton County, Georgia, face disproportionately high rates of HIV and unique structural barriers to pre-exposure prophylaxis (PrEP) uptake and adherence. Sustained adherence among YBMSM remains low due to intersecting structural, social, and behavioral barriers. To address these disparities, this paper presents an adapted implementation of the evidence-based M-Cubed (Mobile Messaging for Men) mHealth intervention. Prior studies of M-Cubed and similar mHealth interventions have shown promising outcomes in increasing PrEP adherence among Black MSM populations. The adapted intervention integrates culturally tailored messaging specific to behaviors …

Protocol For Screening Of Small Molecules In A Cln3 Disease Patient-Specific Ipsc-Derived Neuronal Progenitor Cell Model, Ramu Venkatesan, Paul C. Trippier

Journal Articles: Pharmaceutical Sciences

Although rare, CLN3 disease is the most common neurodegenerative disorder of childhood. Here, we present a protocol for screening small molecules in a CLN3 disease patient-specific induced pluripotent stem cell (iPSC)-derived neuronal progenitor cell (NPC) model. We describe steps for converting human iPSCs (hiPSCs) to neural stem cells (NSCs) and developing NPCs using feeder-free medium and cytokine-based differentiation. We then detail procedures for achieving access to mature neurons. For complete details on the use and execution of this protocol, please refer to Simeon et al.

The Performance Of Neurologically Intact Sequential Shona-English Bilingual Speakers On The Bilingual Aphasia Test, Mcloddy R. Kadyamusuma, Antony R. Joseph

Faculty Publications – Communication Sciences and Disorders

Background
Currently, no standardized culturally and linguistically appropriate assessment tools may be used to provide speech and language assessment for Shona-English bilingual speakers.

Aims
This study examined the performance of Shona-English sequential bilingual speakers on the full versions of the Shona and English Bilingual Aphasia Test (BAT).

Methods and Procedures
The adapted BAT-Sh and BAT-E were administered to 20 neurologically intact sequential bilingual individuals 30 to 40 years of age. Each participant was administered 32 tasks to facilitate a complete assessment of language skills at all levels of processing and for all modalities.

Results
The Shona-English sequential bilingual speakers performed …

Laser-Induced Graphene Sensor For The Electrochemical Detection Of Acetaminophen, Abdellatif Ait Lahcen, Mazhar Sher, Sikander Ameer, Gymama Slaughter

Center for Bioelectronics Publications

Here we present a simple and efficient method for fabricating laser-induced graphene (LIG) electrodes for the electrochemical detection of acetaminophen (AAP), a crucial analgesic and antipyretic that can become toxic at elevated concentrations. Unlike conventional sensors that require intricate chemical modifications, the fabricated LIG-based sensor eliminates the need for functionalization, offering a streamlined sensing solution. The LIG electrodes were characterized using scanning electron microscopy, energy-dispersive spectroscopy, and Raman spectroscopy, which confirmed the formation of a highly porous graphene network with excellent purity and conductivity. Cyclic voltammetry analysis with a ferricyanide redox probe revealed a large electroactive surface area of 1.21 …

Enhancing Nursing Education: A Quality Improvement Project To Mitigate Incivility Among Faculty, Rebecca Mitschele

Doctor of Nursing Practice Projects

Incivility among nursing faculty poses a significant challenge, adversely affecting job satisfaction, mental health, and communication within academic and clinical settings. This Quality Improvement (QI) project addressed this pervasive issue by identifying faculty incivility as a key contributor to high turnover rates and burnout in faculty and students. A mixed-methods approach assessed the prevalence and types of incivility displayed, including surveys and focus group discussions with faculty. The intervention included conflict resolution training, the establishment of an anonymous reporting mechanism, and the development of a framework to revise the faculty handbook specifically to address incidents of incivility. Post-intervention results indicated …

Promoting Student Retention Through Mandatory Remediation, Randi Mccoy

Doctor of Nursing Practice Projects

This DNP Project seeks to identify and evaluate among associate degree nursing (ADN) faculty, will implementing a pilot remediation policy, compared to the current remediation policy, impact faculty perception regarding exam remediation? Exam remediation is important as it helps students understand why they missed questions, how to improve on their next exam, provides guidance and confidence. It is also essential to determine whether required remediation for students after failing an exam promotes student retention, growth, and expansion at a local university in Oklahoma in the setting of an unprecedented program. Does adding required remediation after a failed exam offer students …

Improving Nursing Faculty's Self-Efficacy For Pre-Brief In High Fidelity Simulation: A Quality Improvement Project, Jamie Herron

Doctor of Nursing Practice Projects

High-fidelity simulation (HFS) effectively allows students to practice nursing care in a safe and controlled environment with fewer chances of error or harm. The Society of Simulation in Healthcare (2021) states that best practice standards include pre-briefing, evaluation during simulation, and debriefing. A standardized pre-briefing for faculty during nursing students' high-fidelity simulation was needed in an Oklahoma associate degree nursing (ADN) program. The Society of Simulation in Healthcare (SSH) evidence-based standards of practice include providing a pre-brief before starting a high-fidelity simulation, which decreases the student's anxiety and improves learning. The PICOT question, “How does education about pre-briefing in high-fidelity …

Quality Improvement Project: Reducing Ventilator Days: Evaluating The Effectiveness Of A Nurse-Led Mechanical Ventilation Liberation Protocol In Critical Care Units, Joseph Duncan

Doctor of Nursing Practice Projects

The present study investigated the effect of intensive care unit (ICU) nurses’ knowledge and confidence in managing mechanically ventilated patients’ weaning trials, and whether innovative education can improve these clinical interventions. Current practice relies on an antiquated provider-led protocol that does not account for the nurses’ skill level or practice autonomy. This oversight consistently leads to ventilator associated complications including prolonged ventilation time, increase sedation infusion use and increase ICU length of stay. This study’s aim was to determine if innovative education could improve nursing knowledge and confidence related to ventilated patient care. Nurse participants (N=100) were randomly selected to …

Quality Improvement Project: Improving Access To Early Intervention For Prediabetic Patients In Primary Care, Jude Abam

Doctor of Nursing Practice Projects

Primary care frequently misdiagnoses prediabetes, which serves as a diabetes type 2 precursor, resulting in failed early treatment opportunities. A structured staff education program was the goal of the quality improvement project during the DNP implementation. The initiative addressed knowledge gaps alongside screening protocol standardization all to enhance early detection as well as intervention efforts. Using both Lewin’s Theory of Change and Kolb’s Theory of Experiential Learning, a pre-post-design was applied across seven weeks. Prediabetes screening and management, along with its risk factors, were taught to the staff. The demographic questionnaires helped in assessing the knowledge and self-efficacy of the …

Quality Improvement Project - Virtual Escape Rooms: A Teaching Strategy For Nurse Educators, Alisha Mcafee

Doctor of Nursing Practice Projects

Virtual escape rooms (VERs) are an active learning activity that engages students with learning materials while applying theory and knowledge to life-like patient scenarios. Nursing faculty at one nursing program required education about VER development. The problem identified for this quality improvement (QI) project was the lack of knowledge of the nursing faculty on the use and development of this active learning strategy. This QI project aimed to enhance nurse faculty knowledge and ability to utilize VERs within their courses. Faculty participated in an educational session about VERs. Completion of a pre-and post-questionnaire took place. Three Likert-scale questions were asked …