Medicine and Health Sciences Commons^™

Using Machine Learning To Predict Women At Risk Having A Child With Congenital Heart Defects, Amany M. Abdo Prof., Asmaa M. Mosallam Ms., Laila M. Abdelhamid Assoc.Prof.

Information Systems

Congenital heart defects (CHD) are heart malformations present at birth, affecting heart function and circulation, and are a leading cause of infant mortality. CHD can result from genetic, environmental, and maternal health factors, making early detection essential. Early diagnosis allows for timely intervention, reducing risks like heart failure or stroke. In countries like Egypt, CHD often remains undiagnosed due to limited healthcare resources. Artificial intelligence (AI) can improve early detection by analyzing risk factors. This study presents a predictive model for CHD using maternal and paternal health factors. Data was collected from 571 families: 260 with a CHD-affected child and …

Radiographic Assessment Of Anterior Maxillary Sites Prior To Immediate Implant Placement: A Retrospective Study On Cbct, Elissa El Alam, Abdallah Menhall, Nabil Ghosn, Pierre Lahoud

International Arab Journal of Dentistry

Objectives: The purpose of this retrospective radiographic study was to measure alveolar bone width at the alveolar crest, intraosseous root length, apical bucco-palatal bone thickness and apical bone height at the anterior maxillary teeth prior to immediate implant placement. Dehiscence and fenestration at these sites were also reported.

Methods: 50 CBCTs were included in this study. Measurements were taken on the right and left sides of the central incisor, lateral incisor, and canine using a 3d slicer program. Frequency of fenestration and dehiscence at these sites were also reported.

Results: Mean bone width at the alveolar crest of the central …

Effect Of Different Deep Margin Elevation Thicknesses Versus No Elevation On The Fracture Resistance Of Indirect Restorations: An In-Vitro Study, Fleurene Daraze, Karim Corbani, Brigitte Douaihy, Hadi Jomaah, Cynthia Kassis

International Arab Journal of Dentistry

Objectives: This in-vitro study aimed to evaluate whether different deep margin elevation (DME) thicknesses (1 mm, 2 mm, 3 mm) influence the fracture resistance and fracture type of molars restored with CAD/CAM lithium disilicate overlays, compared to no elevation.

Methods: Seventy-six extracted human molars were randomly divided into four groups (n=19) based on Deep Margin Elevation thickness: 0 mm (control), 1 mm, 2 mm, and 3 mm. Standardized Class II cavities were prepared with cervical margins extending 1 mm below the cementoenamel junction. DME was performed using a low-viscosity hybrid composite. Using a CAD/CAM workflow, overlays were designed and milled …

Effectiveness Of Different Home Bleaching Treatments On Color Change And Tooth Sensitivity: A Split-Mouth Design, Tarek Hanbali, Rim Bourgi, Carlos Enrique Cuevas-Suárez, Monika Lukomska-Szymanska, Walter Devoto, Nicolas Nassar, Naji Kharouf, Louis Hardan

International Arab Journal of Dentistry

Objectives: Dental at-home bleaching is a widely recognized and effective treatment for improving the shade of anterior teeth. However, the impact of varying application times of carbamide peroxide (CP) concentrations on whitening efficacy and tooth sensitivity (TS) remains unclear.

Methods: In this split-mouth, randomized clinical trial, 80 participants were divided into two groups (n = 40 each) to receive either 10% or 16% CP gel for home bleaching. Different application times were tested. Tooth color was measured using the Optishade colorimeter, and TS was evaluated via a five-point analog numerical rating scale. The Friedman test with post hoc Tukey test …

A Comprehensive Analysis Of The Accurate Diagnosis Of Chronic Non-Bacterial Osteomyelitis Of The Jaw In Young Patients: An Assessment Of Clinical And Laboratory Data, Alexander Yu Kugushev, Andrey V. Lopatin, Suzan Dagher

International Arab Journal of Dentistry

Objectives: Chronic non-bacterial osteomyelitis (CNO) is a rare autoinflammatory bone disorder predominantly affecting pediatric and adolescent populations. The clinical presentation is heterogeneous, with persistent pain and swelling representing the most frequent and often initial symptoms. These manifestations are commonly localized to the mandible, although involvement of other skeletal sites, including long bones, clavicle, and vertebrae, may occur in more advanced cases. Beyond localized symptoms, some patients exhibit mild systemic features such as low-grade fever, fatigue, or malaise; however, these systemic signs are generally less pronounced than those observed in infectious osteomyelitis. The diagnostic evaluation of CNO is intricate and necessitates …

The Assessment Of Ageism In Dental Hygiene Students And Dental Hygienists: A Cross-Sectional Study, Paolo Boffano, Elena Canciani, Valeria Nikolovska, Francesca Santeusanio, Andrea Melle

International Arab Journal of Dentistry

Objectives: Ageism is a common type of discrimination and prejudice that consists in the stereotyping and discrimination against individuals or groups on the basis of their age.The purpose of this study was to assess dental hygienists and dental hygiene students’ attitudes toward geriatric patients, the perceptions of curriculum suitability, and their confidence in treating geriatric patients, together with an assessment of ageism in the study population.

Methods: A survey was conducted among dental hygienists and dental hygiene students. The first part of the questionnaire contained questions related to demographics, and regarding their opinion on treatment in the geriatric population. The …

Three-Dimensional Evaluation Of Torque Expression In Maxillary Incisors: Influence Of Crown Shape And Collum Angle, Isha Singh, Achint Juneja, Divya Shetty, Monis Raza, Payal Sharma, Udit Chaudhary

International Arab Journal of Dentistry

Objectives: To evaluate the influence of crown morphology and collum angle of maxillary incisors on torque expression at common bracket-bonding landmarks using cone-beam computed tomography (CBCT).

Methods: Twenty CBCT scans of individuals aged 18–27 years were analyzed. For each central and lateral incisor, the height of maximum labial contour (HMC), height of the labial anatomic (LA) point, collum angle (CA), and alpha angle at both HMC (αc) and LA (αLA) were measured. Stone casts confirmed LA points. Independent and paired t-tests assessed inter- and intra-tooth differences (α = 0.05).

Results: The HMC was located 2.6 ± 0.3 mm (centrals) and …

Artificial Intelligence, An Aid In Teledentistry: A Review, Kavery Ittira Kuttappa, Mamatha Shetty, Upasana Reddy, Srilakshmi Mahadevan

International Arab Journal of Dentistry

The central question is whether teledentistry can effectively access and provide treatment to dental patients. This review seeks to examine how teledentistry improves oral health services through the use of various enabling technologies. This explores the integration of artificial intelligence in teledentistry in modern oral healthcare. Teledentistry expands its access to dental services, especially in remote and undeserved communities through synchronous, asynchronous and remote patient monitoring while reducing costs, logistical barriers and chairside time. It shifts its dynamic from a curative model to a proactive preventive one which focuses on patient centered care. Artificial Intelligence (AI) includes machine learning, deep …

The Effect Of Loading On The Success Of Dental Implants After Immediate Extraction Compared To Delayed Dental Implants: A Systematic Review, Hassen Merzouk, Samir Habibi, Ben Ali Boutabout

International Arab Journal of Dentistry

Introduction: The study focuses on dental implants, which are used to replace missing teeth. A key decision in implant dentistry is when to place the implant relative to tooth extraction. This review compares two main approaches: immediate implant placement (placing the implant during the same surgery as tooth removal) and delayed implant placement (placing the implant after the extraction site has healed, typically 6 to 12 months later).

Objectives: The study aims to compare the success rates and complications associated with these two-timing strategies, especially concerning the implant’s ability to withstand chewing forces. The primary objective was to compare post-extraction …

Role Of Gut Microbiome In Oncogenesis And Oncotherapies, Renuka Sri Sai Peddireddi, Sai Kiran Kuchana, Rohith Kode, Saketh Khammammettu, Aishwarya Koppanatham, Supriya Mattigiri, Harshavardhan Gobburi, Suresh K. Alahari

School of Graduate Studies Faculty Publications

The gut microbiome has emerged as a key regulator of human health, influencing not only metabolism and immunity but also the development and treatment of cancer. Mounting evidence suggests that microbial dysbiosis contributes to oncogenesis by driving chronic inflammation, producing genotoxic metabolites, altering bile acid metabolism, and disrupting epithelial barrier integrity. At the same time, the gut microbiome significantly modulates the host response to oncotherapies including chemotherapy, radiotherapy, and especially immunotherapy, where microbial diversity and specific taxa determine treatment efficacy and toxicity. This review synthesizes current evidence on the role of the gut microbiome in both oncogenesis and oncotherapies, focusing …

Metabolic Syndrome As A Risk Factor For Postoperative Complication In Patients Undergoing Spine Surgery: A Systematic Review And Meta-Analysis Of More Than 3 Million Cases, Amir-Mohammad Asgari, Farhad Shaker, Mohammad Taha Pahlevan Fallahy, Sourena Sharifkashani, Alireza Soltani Khaboushan, Dorsa Salabat, César Carballo Cuello, James Harrop, Puya Alikhani

Department of Neurosurgery Faculty Papers

OBJECTIVE: Including conditions like obesity, diabetes, hypertension, and dyslipidemia, metabolic syndrome disrupts metabolic homeostasis and impairs recovery, increasing the risk of surgical complications. This study evaluates the impact of metabolic syndrome on spine surgery outcomes, addressing inconsistencies in the existing literature.

METHODS: Four databases were searched until December 2024 for studies comparing the postoperative complication rates of spine surgeries between patients with and without metabolic syndrome. Following deduplication, 2 authors independently reviewed the studies. For each included study, demographics and incidence rates of postoperative complications were extracted separately by 2 authors. Data analysis was performed using R.

RESULTS: After deduplication, …

Synergizing Digital And Print: Leveraging Spine Surgeons' Social Media To Transform Publishing And Society Interaction, Benedikt W. Burkhardt, Kai-Uwe Lewandrowski, Choll W. Kim, Morgan P Lorio, Oscar L. Alves, Rossano Kepler Alvim Fiorelli, Sergio Luis Schmidt, Hansen A. Yuan, Alex R. Vaccaro

Department of Orthopaedic Surgery Faculty Papers

BACKGROUND: Social media has fundamentally altered how information is created, disseminated, and consumed, with growing impact on spine surgeons and professional societies. Traditional academic publishing remains the standard for research validation, but digital platforms now shape much of the real-time dialogue in spine care.

OBJECTIVE: To explore strategies for integrating spine surgeons' social media presence with traditional publishing channels to enhance knowledge dissemination, support clinical innovation, and improve member engagement within spine societies.

METHODS: This perspective reviews current patterns of social media use among spine surgeons, focusing on platforms such as X (formerly Twitter), Instagram, and LinkedIn. It analyzes benefits …

Regenerative And Wellness Medicine: A Boon Or Barrier To Surgical Innovation In Degenerative Spine Care?, Álvaro Dowling, Kai-Uwe Lewandrowski, Morgan P. Lorio, Óscar L. Alves, Rossano Kepler Alvim Fiorelli, Sergio Luis Schmidt, Hansen A. Yuan, Alexander R. Vaccaro

Department of Orthopaedic Surgery Faculty Papers

BACKGROUND: Regenerative and wellness medicine is rapidly reshaping health care, particularly in the management of degenerative spine conditions. Noninvasive or minimally invasive options such as stem cell therapy, platelet-rich plasma (PRP) injections, and holistic wellness programs are increasingly selected by patients who wish to avoid the risks, costs, and prolonged recovery associated with elective spine surgery.

PURPOSE: This perspective article examines whether regenerative and wellness approaches function primarily as a boon or a barrier to innovation in spine surgery and explores their impact on traditional, insurance-based surgical care models.

METHODS: Using a narrative, opinion-based framework, this article synthesizes current trends …

Work-Related Musculoskeletal Disorders: Epidemiology, Risk Factors, Socioeconomic Impact And Prevention - A Narrative Review, Swarna Radhakrishnan, Harini Ramendran, Priyanga Thirunavukkarasu

Digital Journal of Clinical Medicine

Abstract

Work-related musculoskeletal disorders (WMSDs) represent one of the most pervasive and costly occupational health challenges worldwide. Affecting muscles, tendons, ligaments, nerves, joints, and supporting blood vessels, these conditions arise from a complex interplay of physical, psychosocial, organizational, and individual risk factors present across diverse work environments. From factory floors and construction sites to offices and healthcare settings, WMSDs contribute substantially to pain, disability, reduced productivity, absenteeism, and diminished quality of life. This narrative review synthesizes existing literature on the epidemiology, pathophysiology, risk factors, and socioeconomic impact of WMSDs, with particular attention to high-risk occupational sectors. It further discusses prevention …

Retinal Vasculature In Schizophrenia Spectrum Disorder, Caroline Simon Sherman, Erik Gunnarsson, Nycole Hidalgo, Victoria Chen, Kevin Zhang, Shuo Chen, Hwiyoung Lee, Hugh O'Neill, L Elliot Hong, Osamah Saeedi

Faculty, Staff and Student Publications

The purpose of this research is to determine whether retinal vasculatures differ between participants with schizophrenia spectrum disorder (SSD) and controls. Ninety participants (51 SSD, mean age 35.8 ± 13.5, and 39 controls, mean age 35.5 ± 11.4) underwent 3 × 3 mm2 macular and 6 × 6 mm2 optic nerve head (ONH) optical coherence tomography angiography (OCTA) scans. En face macula and ONH region images were divided into quadrants, binarized, and then skeletonized. Skeletonized vessel densities were compared between our two groups. Additionally, the foveal avascular zone (FAZ) size and acircularity index were compared between the two groups. There …

Feeding Difficulties And Survival Outcomes In Advanced Dementia: A Multicentre Retrospective Study From Oman, Fatma Al-Shamsi, Ahmed Al-Darmaki, Said A Al-Busafi, Hamed Al-Sinawi, Ahmed Al-Harrasi, Athba Al-Ajmi, Abdullah Mohammed Al Alawi

Sultan Qaboos University Medical Journal

Objectives: Feeding problems are among the most common in patients with advanced dementia. This study aimed to assess the prevalence of feeding problems and evaluate survival outcomes following the onset of feeding problems in patients with advanced dementia. Methods: A retrospective cohort study of adults with advanced dementia identified from the electronic patient record using diagnostic codes and keyword searches was conducted. This multicentre study took place at Sultan Qaboos University Hospital, Muscat, Oman and the Royal Hospital, Muscat, Oman, from January 2010 to December 2023. Results: A total of 202 patients were included. The median age was 78.5 …

Severe Drug-Induced Gingival Overgrowth In A 21-Year-Old: A Rare Presentation And Its Surgical Resolution, Raagul Somasundaram, Sumit Malhotra, Rahul Chopra, Gaurav Das

International Arab Journal of Dentistry

Gingival overgrowth is well documented side effect associated with three major classes of drugs viz, anticonvulsants, calcium channel blockers, and immunosuppressants. Dental Surgeons need to discuss this issue with their medical colleagues and to practice care while prescribing the drugs associated with gingival overgrowth. The aim of present article is to report a rare case of gingival enlargement with long term Drug history. Drug-induced gingival enlargement often occurs due to patient’s lack of awareness about the side effects of prescribed medications. This case report presents with an unusual rare instance of massive drug-induced gingival overgrowth in a 21-year-old male, successfully …

Management Of Anterior Teeth Affected By Molar Incisor Hypomineralization Using Resin Infiltration Technique: A Case Report, Atika Bouabid, Selsebil Laajimi, Yamina Elelmi, Fatma Masmoudi, Ahlem Baaziz

International Arab Journal of Dentistry

Background: Molar-Incisor Hypomineralization (MIH) is a developmental enamel defect affecting first permanent molars and often incisors, presenting unique restorative challenges. In line with minimally invasive dentistry, the “Würzburg concept” promotes conservative management strategies with resin infiltration.

Objectives: This case report investigates the impact of modifications to the ICON resin infiltration protocol on esthetic outcomes and adhesion in MIH-affected anterior teeth.

Method: Three clinical cases involving MIH lesions on anterior teeth were treated using the Icon® resin infiltration system by DMG (Hamburg, Germany).

Results: Preconditioning hypomineralized enamel with 5.25% sodium hypochlorite followed by resin infiltration enhances the physical integrity of composite …

Comparative Evaluation Of The Solubility Of Three Commonly Used Root Canal Sealers When Exposed To Xylene And Endosolv: An In Vitro Study, Aparna Palekar, Piyush Mantri, Basawaraj Biradar, Mukund Singh, Vaidehi Joshi, Pushpal Ingle

International Arab Journal of Dentistry

Objectives: This in vitro study compared the solubility of three root canal sealers, AH Plus (epoxy resin-based), MTA Fillapex (MTA-based), and Cerafill RCS (bioceramic), in two solvents: Xylene and Endosolv.

Methods: Sixty standardized cylindrical specimens were prepared using the three sealers of interest. The specimens were divided into six groups (n = 10) and immersed in either Xylene or Endosolv for 10 minutes. Solubility was assessed by calculating the percentage weight loss before and after immersion. Data were analysed using one-way ANOVA and Tukey’s post hoc test (α= 0.05).

Results: All sealers exhibited statistically significant solubility in both solvents (p …

Effect Of Red Wine Immersion On The Flexural Strength Of Glass Ionomer Cement: An In Vitro Study, Niyola Crasta, Upasana Reddy, Jayaprakash Kukkila

International Arab Journal of Dentistry

Background: Alcoholic beverages such as red wine are widely consumed for social and cultural reasons. Ethanol and other constituents in red wine might alter the physical properties of dental restorative materials, particularly those exposed in the oral environment. Glass ionomer cements (GICs) are commonly used in restorative dentistry for their beneficial properties, but their mechanical strength under exposure to acidic or alcoholic solutions is a concern.

Objectives: To evaluate how exposure to red wine over time affects the flexural strength of glass ionomer cement (Shofu FX Ultra Mini).

Methods: Thirty rectangular specimens of glass ionomer cement (Shofu FX Ultra Mini), …

Interdisciplinary Full-Mouth Rehabilitation Addressing Midline Shift And Gingival Discrepancies Through Crown Lengthening And Root Reshaping Procedures: A Case Report, Ghida Lawand, Roudy Khayat, Stephanie Khalaf, Tamara Rebeiz, Hani Tohme

International Arab Journal of Dentistry

This report describes a minimally invasive approach to address midline deviation and gingival discrepancies in a 50-year-old patient seeking rapid aesthetic results. Treatment included prosthetic crown lengthening, selective root modification, and biologic shaping to correct a 3 mm midline shift. Digital smile design and CAD/CAM technology guided the fabrication of zirconia restorations, achieving improved midline alignment, gingival harmony, and smile aesthetics with high patient satisfaction. This technique provides an efficient alternative for complex aesthetic cases.

Exploring Cellular Heterogeneity: Single-Cell And Spatial Transcriptomics Of Alzheimer's Disease Brains And Ipsc-Derived Microglia, Anjali Garg, Sheeny Vo, Iara D De Souza, Ayslan Castro Brant, Logan Brase, Ekaterina Aladyeva, Ricardo D 'O Albanus, Aasritha Nallapu, Hongjun Fu, Oscar Harari

2020-Current year OA Pubs

BACKGROUND: Microglia, the brain’s resident immune cells, play a pivotal role in Alzheimer’s disease (AD) pathogenesis. These cells exhibit diverse transcriptional states in response to neuroinflammatory stimuli, and characterizing these states is essential for understanding AD mechanisms. METHODS: We integrated single-cell and spatial transcriptomic datasets from multiple cohorts and brain regions, encompassing both experimental models and human tissues. Findings were validated through immunostaining of human brain samples. RESULTS: Our comprehensive atlas revealed pronounced heterogeneity among microglial states, with disease-associated microglia (DAM) significantly enriched in AD brains compared to controls. Spatial transcriptomics and immunohistochemistry demonstrated that DAM predominantly localize to external …

Evaluating The Analgesic Activity Of The Ethanolic Leaf Extract Of Ipomoea Aquatica (Convolvulaceae), Blessy H. Vale, Lenny Shai Somer, Julie Mae Suico, Roselle L. Remulta, Junnin Gay Garay

Pacific Journal of Health

Ipomoea aquatica, commonly known as water spinach, is a leafy vegetable widely consumed in tropical and subtropical regions for its nutritional benefits. This study investigated the potential analgesic activity of the ethanolic leaf extract of I. aquatica, as no prior scientific evidence supports its role in acute pain management. Male Swiss albino mice were used in an acetic acid-induced writhing test, with aspirin as the positive control and plain normal saline solution (PNSS) as the negative control. The extract was administered at low, medium, and high doses. In the writhing test, I. aquatica significantly inhibited the writhing response …

Is It Rape Or Consent? College Men Just Don’T Know, Stephanie A. Navarro Silvera, Eva S. S. Goldfarb, Amanda S. Birnbaum, Lisa D. Lieberman

Department of Public Health Scholarship and Creative Works

Introduction: Women and LGBTQ+ undergraduates face higher rates of sexual assault and rape compared to cisgender male peers—the overwhelming majority of perpetrators. Federal policies have aimed to curb campus sexual violence, yet questions remain about the efficacy of consent education, particularly among cisgender heterosexual men. Methods: This study surveyed 1567 undergraduate students at a large Northeastern public university in 2017 and 2022. Responses to a nine-item consent scale were analyzed by gender, sexuality, and demographic factors. Results: Cisgender heterosexual (cis-het) men had poorer understanding of consent compared to women and LGBTQ+ students, both in 2017 and 2022. Cis-het men’s consent …

Mediapipe-Based Extraction Of Joint Rom And Position From Patient Videos For The Functional Movement Screen: An Exploratory Study, Joshua Paul Verdillo, Lily Ann Bautista

Philippine Journal of Physical Therapy

Introduction. The Functional Movement Screen (FMS) is widely used to identify movement deficiencies and potential injury risk. However, its reliance on visual inspection introduces subjectivity, requires specialized training, and necessitates face-to-face assessment. Advances in computer vision, offer opportunities to automate and better objectify functional movement assessment. This exploratory study aimed to evaluate the feasibility of using a MediaPipe-based system, Software-Optimized Movement Assessment (SOMA), to extract joint range of motion (ROM), joint position, and compensatory movement patterns from patient videos during FMS performance.

Methods. SOMA was developed using MediaPipe Pose and MediaPipe Hands libraries integrated with Python-based tools to analyze videos …

Biomechanics Of The Ribs During Respiration At The Costotransverse Joint: An In-Vivo Retrospective Pilot Study, Michael Maninang, Greg Almeter, Erik Pearson, Arvie Vitente

Philippine Journal of Physical Therapy

Introduction: Scarce in‑vivo data describe how ribs move at the costotransverse joints during quiet breathing—knowledge critical to thoracic biomechanics and pain mechanisms. This pilot study uses four‑dimensional computed tomography (4D‑CT) to quantify, for the first time, the three‑dimensional magnitude and direction of rib motion at these joints throughout quiet respiration.

Methods: This retrospective, descriptive pilot study analyzed ten 4D‑CT scans obtained from patients undergoing thoracic imaging prior to radiation therapy. End‑expiration and end‑inspiration phases were aligned with a demons deformable‑registration algorithm. For each costotransverse joint, the three‑dimensional displacement vector, its absolute magnitude, and its components along the lateral–medial (L–M), …

Standardizing Assessment Of Clinical Performance In Physical Therapy: From Good Intentions To Shared Standards, Arvie Vitente, Carmina Rafael, Rolando Lazaro

Philippine Journal of Physical Therapy

Clinical education is the crucible in which physical therapy students integrate knowledge, skills, and professional judgment into safe, ethical, and person-centered practice. Yet globally, the assessment of clinical performance remains highly variable, shaped by disparate tools, rubrics, and levels of assessor preparation. While several countries have adopted nationally standardized approaches to clinical assessment, many contexts—including the Philippines—continue to rely on locally developed or institution-specific systems, resulting in inconsistent expectations, inequitable student experiences, and limited capacity for benchmarking, research, and quality improvement. This editorial argues that good intentions alone are insufficient and that the profession must move toward shared, trustworthy standards …

Precision Education In Health Sciences Education: A Call-To-Action For Developing An Interprofessional Strategy, Arvie Vitente, Jennifer Bosworth, Robert Sweet, Rebecca Cozzi, Christopher Galloway, Piotr Szczurek, Melanie Obispo-Young, Eron Bozec, Erica Brkovic, Tina Bobo, Jennifer Lubinski

Philippine Journal of Physical Therapy

Introduction. Growing learner diversity, expanding biomedical knowledge, and rapid clinical digitization have exposed the limits of on-size-fits-all health sciences training. Competency-Based Education (CBE) has sharpened the focus on outcomes, yet many programs still move learners through fixed sequences, infrequent assessments, and retrospective remediation. Precision Education (PE) offers a complementary, data-enabled approach that uses learning analytics, artificial intelligence (AI), and continuous feedback loops. Embedded within CBE, PE converts competencies from static milestones into dynamic trajectories that can be measured, visualized, and adjusted in real time across the curriculum. This abstract highlights the need for an interprofessional strategy to design, fund, and …

A Spatiotemporal Model Of Cxcl10 As A Master Regulator Of Immune Evasion And Metastasis In Osteosarcoma, Benjamin B Gyau, Tsz-Kwong Man

Faculty, Staff and Students Publications

The C-X-C motif chemokine ligand 10 (CXCL10) is implicated in the progression of osteosarcoma (OS), the most aggressive pediatric bone malignancy. However, its role often presents a profound clinical paradox: although high circulating levels are strongly linked to poor prognosis, its canonical function is to recruit anti-tumor immune cells. This review unravels these contrasting roles by proposing a novel spatiotemporal model. We argue that in the early stages, immune-evading OS cells initiate the formation of a pre-metastatic niche (PMN) in the lungs, creating a localized inflammatory environment that becomes the primary source of elevated circulating CXCL10. As the disease progresses, …

Amino Acid Signaling In Skeletal Muscle Is Blunted By Prematurity In A Piglet Model, Antonio C Ramos Dos Santos, Agus Suryawan, Ki Beom Jang, Rosemarie D Parada, Mahmoud A Mohammad, Marta L Fiorotto, Teresa A Davis

Faculty, Staff and Students Publications

Background: Preterm (PT) infants are at increased risk for reduced postnatal lean mass accretion. We established that the feeding-induced stimulation of protein synthesis in skeletal muscle is blunted in piglets born PT compared with those born at term.

Objectives: We evaluated the extent to which key components of the amino acid-sensing pathways that regulate mechanistic target of rapamycin complex 1 (mTORC1) activation contribute to anabolic resistance in skeletal muscle of piglets born PT compared with those born term.

Methods: Piglets delivered by cesarean section 10 d PT (n = 23) or at term (n = 22) were administered total parenteral …