Medicine and Health Sciences Commons^™

Nursing Students’ Attitudes And Preparedness For Maid, Kristal Candray

Nursing | Senior Theses

Medical assistance in dying (MAiD) also known as physician-assisted suicide in addition to euthanasia is on the rise with an increase in decriminalization of the practice(s) and enactment of practice-protected policies in many countries. Ethics and morals on the subject continue to be controversial in healthcare. As student nurses enter the field as clinicians, they may encounter a patient requesting MAiD. Studies from students in other countries where MAiD and/or euthanasia is practiced found that student nurses do not feel adequately prepared to navigate such situations. However, although MAiD has been legalized in a handful of states within the United …

Nurses Current State Of Knowledge On Prion Disease, Chelsy Grande

Nursing | Senior Theses

Background: Prion disease is a rare neurodegenerative disorder that affects the central nervous system. Creutzfeldt-Jakob prion disease rapidly progresses, caused by an infectious pathogen that misfolds the normal prion protein which results in an accumulation of cellular prion proteins. Unfortunately, there is no cure for Creutzfeldt-Jakob disease, only palliative care to provide support as the disease progresses. There is a gap in providing support for the patients and their families due to the limited understanding from the nurses, which can lead to the unmet needs of patients and their families. The purpose of the study is to evaluate what nurses …

African-American Perceptions On The Importance Of Racially-Concordant Care, John Moya

Nursing | Senior Theses

Racial concordance is defined as a relationship in which a healthcare provider and patient share the same race. Racially concordant care has been, in previous research, associated with improved health outcomes, particularly in minority populations such as African-Americans Despite this, little is known about how African-American patients perceive racial concordance, and how important it is to their care. The focus of this research proposal is to determine the perceptions of African-American patients on racial concordance and racially concordant care, and how important they deem it to be to their care. The literature review delves into racial concordance and its presence …

Education On The Early Recognition Of Antepartum Sepsis For Labor And Delivery Nurses, Diana Egan

Nursing | Senior Theses

Even though rare in occurrence, sepsis in pregnancy causes high morbidity and mortality rates, most deaths preventable with timely recognition and intervention. With symptoms difficult to identify, adjusted screening tools were created. The literature review highlighted the importance of using approaches such as these tools to improve on maternal outcomes and treatment. The review displayed how nurses in other departments find difficulty defining and identifying sepsis in adults as well as education surrounding interventions in maternal sepsis and obstetrical emergencies improve knowledge deficits. In response, questions emerge about what labor and delivery nurses know about recognizing sepsis in the pregnant …

Evaluating Pulmonary Tuberculosis Knowledge Deficits Among Nursing Students In The United States, Jamie Lynn Woo

Nursing | Senior Theses

The healthcare field consistently faces patients with a wide range of diseases and illnesses. Pulmonary Tuberculosis is an infectious lung disease with established tools to prevent, detect, and treat it. Yet, there has been a significant rise in cases within the past year. Amidst this troubling situation, it is crucial that all healthcare workers, nursing students, and nurses in particular, are properly educated on caring for TB patients. This research proposal aims to determine if there are TB treatment knowledge gaps among nursing students in the United States by conducting a 20-question survey utilizing the Likert Scale. If results show …

Nurses’ Perception On The Gut-Brain Axis And Its Implications On Mental Health, Geethika Manoj, Celine Bautista

Nursing | Senior Theses

Background: Most medical interventions recommended for patients with anxiety and depression include pharmacological treatments and psychotherapy. Thus, undermining the existence of modifiable risk factors, such as diet. Despite being an area of growing research, the gut-brain axis is a very broad topic among the healthcare field. Purpose: The purpose of this study is to investigate registered nurses’ perceptions and understanding of the gut-brain axis and its implications for mental health management. Methods: This proposed exploratory descriptive study will conduct research among fifteen registered nurses, each with at least two years of experience in specialties such as gastroenterology, psychiatry, or hospital …

Cognitive Behavioral Therapy For Postpartum Depression And Suicide Prevention In Asian Women, Emily Tan

Nursing | Senior Theses

Purpose

This paper examines the impact of a culturally centered cognitive behavioral therapy (CBT) and postpartum depression (PPD) education on reducing PPD which will prevent maternal suicide among Asian American mothers. There is stigma around PPD among Asian American mothers, and there’s a lack of research on culturally sensitive interventions. This emphasized the need for nurses to promote help-seeking practices and reduce mental health stigma in this community.

Methods

This quantitative true experimental design aims to evaluate the effectiveness of culturally competent CBT in reducing PPD thus ultimately decreasing maternal suicide. The sample will consist of 120 postpartum Asian American …

Optimizing Discharge Education For Patients With Heart Failure, Connie-Rose Pangan

Nursing | Senior Theses

Noncompliance can be a result of a lack of comprehension of discharge instructions and a lack of concise, effective educational resources. Due to this deficit, patients with heart failure are less likely to comply with their discharge protocol and are therefore more likely to be readmitted to the hospital. The aim of the study is to consolidate a teaching method that accommodates one's existing educational barriers, implement follow-up to increase knowledge retention and improve self care, and prevent readmission among HF patients. Two hundred hospitalized, English-speaking patients with heart failure above 65 years old across 20 US Hospitals will be …

Implementation Of Robotics And Artificial Intelligence To Oncological Surgery, Ian Ngo

Nursing | Senior Theses

Background/ significance: Introduced in the late 20th century, robotic systems have enhanced surgeons’ capabilities by providing accurate and precise control of instruments. These systems helped minimize invasiveness in surgical procedures, providing greater precision, and gave flexibility to difficult-to-access areas of the body. Tools powered by AI help surgeons accurately identify and remove cancerous tissues, which can lead to better surgical outcomes and fewer complications. Purpose: The purpose of this study is to focus on evaluating how Robotic-Assisted Systems (RAS) and Artificial Intelligence (AI) impact surgical precision, patient recovery, and to address economic efficiencies. associated with integrating said systems into the …

The Impact Of Complementary Therapies On Postpartum Pain Relief Among Mothers Of Multiples, Jewel Thomas

Nursing | Senior Theses

The process of recovery after birth can be an arduous process for many women. Many patients experience discomfort that affects their quality of life. Especially for mothers who give birth to twins or triplets, there is additional need for support in this crucial time as they are more likely to develop postpartum complications. Current management for postpartum pain include pain control medications and heat/cold therapy. The purpose of this proposal is to examine if complementary therapies such as aromatherapy and music therapy decreases the postpartum pain levels in mothers of multiples. This paper proposes an experimental trial, in which a …

Impact Of Whole Foods Diet On Cognitive Functions In Children From Low-Income Families With Attention Deficit Hyperactivity Disorder (Adhd), Jasmine Le

Nursing | Senior Theses

Purpose

Current studies have examined dietary interventions for ADHD, emphasizing the value of good nutrition, the lack of nutritional foods in schools, and the difficulties low-income families have finding healthy options. Nutritious food has been shown to enhance cognitive abilities, yet many low-income households still lack access to it. This quantitative research will provide vital information for nurses and healthcare professionals on how they can assist these populations.

Methods

A quantitative randomized controlled design study will be conducted, with students separated into an experimental and control group. The objective will be to evaluate the effects of nursing nutrition education and …

Reducing Levels Of Compassion Fatigue Among Generation Z Hospital Nurses, Kailani Yee

Nursing | Senior Theses

Background: Compassion fatigue is a critical issue and one of the many difficulties encompassed within the nursing profession. It affects a large number of registered nurses who work in hospital settings and who are constantly exposed to the suffering of others. With more young nurses entering the workforce, it's imperative that there is a better understanding of how to properly address this issue among the youngest generation of nurses: Generation Z, or those born between 1997-2012.

Objective: This research proposal aims to explore the most effective strategies to decrease levels of compassion fatigue in Generation Z nurses working in hospital …

The Critical Role Of External Involvement In Supporting Adolescent Mothers Facing Postpartum Depression, Samantha Campopiano

Nursing | Senior Theses

Postpartum depression (PPD) is a significant mental health concern for adolescent mothers, especially those without a reliable support system. The current research demonstrates the importance of a support system, effective interventions, and prevention strategies for easier navigation of postpartum depression. Some effective interventions researched were therapy groups, personalized home visits, and using social media platforms to deliver therapy. This research proposal aims to examine the effectiveness of a nurse-led educational intervention for postpartum adolescent mothers without support. A quasi-experimental design will be used, with pre-and post-test assessments using the Edinburgh Postnatal Depression Scale (EPDS) to measure PPD symptoms in 100 …

Impact Of Non-Pharmacological Interventions On Immunization-Related Anxiety Among Pediatric Patients, Jessica Ho

Nursing | Senior Theses

Immunization-related anxiety can lead to vaccine hesitancy, which can be detrimental to public health by reducing herd immunity and increasing the spread of preventable diseases. This research proposal aims to investigate how nurses implementing non-pharmacological interventions can reduce immunization-related anxiety among pediatric patients. The literature critique focuses on examining the efficacy of various non-pharmacological interventions on reducing procedural pain, fear, and anxiety in pediatric patients. Research shows that those who received non-pharmacological interventions experienced decreased pain, fear, and anxiety levels. This proposal will use a randomized control trial design with a convenience sample of 200 pediatric patients from flu clinics …

The Impact Of A Educational Program On Depression And Anxiety For Low Socioeconomic Latina Postpartum Mothers, Lizbeth Valdez Duran

Nursing | Senior Theses

Postpartum depression (PPD) and anxiety are significant mental health challenges that affect many mothers, especially Latina women with low socioeconomic backgrounds. These mothers often face barriers to care, health literacy, and access to healthcare resources. The problem is compounded by a lack of culturally competent care, which can contribute to mistrust of healthcare providers and discourage Latina mothers from seeking help. The literature review articles highlight that health literacy plays a crucial role in managing mental health, with effective education potentially reducing negative outcomes by improving coping strategies and bringing awareness to symptoms that are associated with postpartum. This research …

Nursing Education On Sleep Health And Its Impact On Insulin Resistance In Adolescents, Salamasina Tufa

Nursing | Senior Theses

Modern-day adolescents are increasingly at risk for poor sleep quality due to rapid physical and physiological changes and stressors from technology and social media. Recent research suggests poor sleep affects endocrine function and contributes to insulin resistance (IR), a precursor to Type II Diabetes Mellitus (T2DM). This proposed quasi-experimental study will examine if a nurse-led sleep education program can improve sleep quality and decrease the incidence of IR in adolescents with poor sleep. A total of 100 participants aged 12-18 across Berkley, California who score ≥ 5 on the Pittsburgh Sleep Quality Index (PSQI) will be randomly assigned to either …

Preparing Nurses For Medical-Assistance In Dying: The Role Of Comprehensive Education And Training, Keira O'Reilly

Nursing | Senior Theses

Medical-assistance in dying (MAID) is a process in which a consenting patient self-administers lethal medications with the intent of ending their life. This process is marked with ethical, emotional, and spiritual complexities. Nurses play a key role in MAID, through providing care as well as being a patient advocate. Specifically, intensive care unit (ICU) nurses often provide care to critical or terminally ill patients. However, according to the research, little formal training or education about MAID has been put into place for ICU nurses. To investigate, primary research articles regarding healthcare professionals’ experiences with MAID, educational gaps, and current training …

Delayed And Misdiagnosed Endometriosis, Teresa Doyle

Nursing | Senior Theses

Aim: This research investigates whether targeted education can improve the early diagnosis of endometriosis, a chronic condition affecting around 10% of women of reproductive age. Unfortunately, endometriosis is often misdiagnosed, delaying treatment, prolonging discomfort, and lowering quality of life. Healthcare practitioners' knowledge gap is addressed by this study, which examines whether organized training promotes awareness and diagnostic accuracy. This research proposal evaluates an educational intervention developed to improve gynecological experts' knowledge and diagnostic skills. The main research issue is whether the intervention reduces misdiagnosis and improves patient outcomes. A quasi-experimental design will examine participants' knowledge and diagnosis accuracy before and …

Understanding Avoidant Restrictive Food Intake Disorder (Arfid) In Autistic Children Through Parent’S Lens, Lisette Oviedo

Nursing | Senior Theses

This research reviews and proposes a study to assess parents' knowledge about their children with a dual diagnosis of autism and Avoidant-Restrictive Food Intake Disorder (ARFID) with the intent to develop future care strategies that are both person-centered and family-centered.

Shadows Of Self Doubt: Exploring The Dual Threat Of Impostor Syndrome On New Nurses And Quality Care, Siona Patel

Nursing | Senior Theses

Every nursing student goes through a transition period after nursing school where they step into the role of a new graduate nurse, and adapt to the demands of the clinical setting. Their acquired knowledge and skills taught to them are now applied to high stake situations of the real world. This critical time period is often paired with a mental phenomenon known as imposter syndrome in which competent people feel doubt or fraudulently of their skill set which can affect patient care and cause burnout. This thesis explores the connection between imposter syndrome and burnout and their impact on patient …

Nursing Knowledge Regarding Pap Smears For Transgender Men, Caytlin Capulong

Nursing | Senior Theses

Cervical cancer screening (CCS) is a crucial test used for preventative measures against cervical cancer, yet transgender men (TM) experience significantly lower screening rates in comparison to cisgender women due to pain, anxiety, and systemic healthcare barriers. A major factor for deterrence is pain during speculum insertion, often because of vaginal atrophy related to testosterone usage. Other factors include fear of discrimination, mistreatment, and lack of provider awareness, particularly among nurses who play a pivotal role in patient preparation and care. This research aims to assess the extent of nurses’ knowledge regarding Pap smears for female-to-male (FTM) patients through a …

The Impact Of Workplace Stressors On Anxiety Levels And Mental Health Among Pediatric Intensive Care Nurses, Kelsey Ang

Nursing | Senior Theses

Background: Pediatric Intensive Care Unit (PICU) nurses work in a high-stress environment where they are exposed daily to traumatic situations. The demanding emotional and physical challenges contribute to significant psychological burdens, including increased stress and anxiety. Purpose: The current paper proposes a research design to examine the outcomes of stress, anxiety levels, and mental well-being on PICU nurses when workplace support and structured debriefing sessions take place following a traumatic event. Methods: Participants will be recruited from PICU hospitals in Northern California. Participation will be voluntary, and informed consent will be obtained prior to the study. The selection criteria will …

The Impact Of Maternal Mental Health On Child Development, Jessica White

Nursing | Senior Theses

Purpose

This research investigates the impact of early maternal mental health interventions on child development, focusing on cognitive, emotional, and social behaviors. The study aims to evaluate whether children whose mothers receive mental health interventions, such as support for depression and anxiety, show improved developmental outcomes compared to children whose mothers do not receive such interventions.

Methods

The study will include 100 mother-child pairs, recruited from clinics in Northern California. Child developmental outcomes will be assessed using standardized tools: Wechsler Intelligence Scale for Children (WISC-V), Strengths and Difficulties Questionnaire (SDQ), and Social Skills Improvement System Rating Scales (SSIS-RS). Follow-ups will …

The Impact Of Sleep Deprivation On Maternal Decision-Making And Risk-Taking Behavior, Stephanie Marea B. Martinez

Nursing | Senior Theses

Purpose

The purpose of this research proposal aims to explore the impact of sleep education in new mothers and their ability to manage sleep deprivation with interventions during the postpartum period.

Methods

This research proposal includes various methods to evaluate the effectiveness of sleep education and mental health screenings in new mothers. The baseline data for sleep quality, postpartum depression, and the new adaptation to motherhood will be collected using the Edinburgh Postnatal Depression Scale, actigraphy to monitor sleep patterns, and a conduction of cognitive functioning with the Mini-Mental State Examination. After interventions are put into place, follow up data …

Targeting Rna Polymerase I In Ewing Sarcoma Treatment, Alexis Bruce, Gavin Anchondo, Rebekah Carter, Sergio Guerrero Pacheco, Hema Sri Kambala, Elizabeth Cortez, Kyra Parker, Le Su

Research, Publications & Creative Work

Ewing sarcoma (ES) is a high-grade bone and soft tissue tumor in adolescents and young adults. Cytotoxic chemotherapy does not improve prognosis, especially for advanced ES patients who have a 5-year survival of 30% or less [1, 2]. Molecular targeted therapy emerges as a promising strategy to battle ES, given its unique driver mutations resulting from the fusion of the EWS and one of the ETS genes, but the feasibility of directly blocking EWS-ETS function has not yet been established [3]. To search for new therapeutic targets, we began with an analysis of the Cancer Dependency Map (DepMap) datasets that …

High-Dose Beta-Alanine Supplementation For Two Weeks Did Not Enhance Intermittent Endurance Or Sprint Performance In Trained Futsal Players, Hossein Miraftabi, Erfan Berjisian, Marzieh Nouri Dizicheh, Alireza Naderi, Masoud Bodaghi, Majid Koozehchian, Fatemeh Shabkhiz, Alvaro Lopez-Samanes

Research, Publications & Creative Work

Background: This study aimed to investigate the effects of a high-dose beta-alanine (BA) supplementation on physical performance, blood lactate concentration, and ratings of perceived exertion (RPE) in trained futsal players. Methods: Sixteen trained futsal players participated in a randomized, parallel, double- blind experiment, completing a two-week supplementation period with either 12 g/day of BA (n = 8; age: 19 ± 2 years; height: 1.78 ± 0.03 m; body mass: 68.5 ± 5.4 kg) or a placebo (PLA) (n = 8; age: 18 ± 1 years; height: 1.74 ± 0.08 m; body mass: 65.6 ± 6.4 kg). Athletes completed the futsal …

Trends In U.S. Health Care Bankruptcy: A 10-Year Retrospective, Amy Yarbrough Landry, Philip Cendoma, Kristine R. Hearld, J'Aime C. Jennings, Robert J. Landry Iii

Research, Publications & Creative Work

Background: In recent years, the United States (U.S.) healthcare system has faced financial challenges resulting from changing reimbursement models, fluctuations in sources of investment, and a global pandemic. These factors have resulted in an influx of bankruptcy filings among healthcare organizations. This study explores the number of healthcare organizations filing for bankruptcy as means to reorganize (Chapter 11) or liquidate assets (Chapter 7), and examines whether organizational size, defined by assets and liabilities, influences the success of reorganization. The research on bankruptcy among healthcare organizations has been limited to larger businesses including hospitals and nursing homes. This study investigates all …

Dose–Response Effects Of Short-Term Rhodiola Rosea (Golden Root Extract) Supplementation On Anaerobic Exercise Performance And Cognitive Function In Resistance-Trained Athletes: A Randomized, Crossover, Double-Blind, And Placebo-Controlled Study, Majid Koozehchian, Andrew T. Newton, Gina Mabrey, Faith M. Bonness, Rafaela Rafajlovska, Alireza Naderi

Research, Publications & Creative Work

Background: Rhodiola rosea (RR) is marketed as an adaptogen; however, evidence for acute/short-term effects—and especially dose–response effects—in trained adults across performance and cognition is limited.

Objective: Test whether RR improves resistance performance (strength, power) and executive function in resistance-trained adults using a randomized crossover with placebo and a capsule-free baseline.

Methods: In a randomized, double-blind, crossover trial with four conditions—no-capsule control (CON), placebo (PL), low-dose RR (LDRR), and high-dose RR (HDRR). Twenty-seven resistance-trained adults completed the conditions. Day-7 testing included bench press (BP) and leg press (LP) 1-repetition maximum (1RM); a third set to failure at 60% 1RM with set-3 …

Formulation Development Of Dual-Compartment Topical Inserts Combining Tenofovir Alafenamide And Elvitegravir For Flexible On-Demand Hiv Prevention, Vivek Agrahari, M. Melissa Peet, Neelima Chandra, Prakash Ramalingam, Pardeep K. Gupta, Sriramakamal Jonnalagadda, Onkar N. Singh, Timothy J. Mccormick, Gustavo F. Doncel, Meredith R. Clark

Department of Obstetrics & Gynecology Faculty Publications

Pre-exposure prophylaxis (PrEP) has emerged as a prominent approach for the prevention of HIV infections. While the latest advances have resulted in effective oral and injectable product options, there are still gaps in on-demand, event-driven, topical products for HIV prevention that are safe and effective. Here we describe the formulation development of a dual-compartment topical insert containing tenofovir alafenamide fumarate (TAF) and elvitegravir (EVG) that may be administered when needed, vaginally or rectally, pre- or post-coitus, for flexible HIV prophylaxis. Specifically, we describe the lab-scale formulation development, preclinical mucosal safety and pharmacokinetics (PK) testing in rabbits, long-term stability, and scale-up …

In Danger: Hiv Vaccine Research And Development In Europe, Roger Tatoud, Yves Lévy, Roger Le Grand, Jose Alcami, Giorgio Barbareschi, Christian Brander, Andrea Cara, Behazine Combadière, François Dabis, Sarah Fidler, Tomáš Hanke, Carolina Herrera, Gunilla B. Karlsson Hedestam, Hester Kuipers, Sheena Mccormack, Christiane Moog, Giuseppe Pantaleo, Laura Richert, Rogier W. Sanders, Robin Shattock, Hendrik Streeck, Rodolphe Thiebaut, Alexandra Trkola, Klaus Üeberla, Marit J. Van Gills, Ralf Wagner, Winfried Weissenhorn, Yazdan Yazdanpanah, Gabriella Scarlatti, Jean Daniel Lelièvre

Department of Obstetrics & Gynecology Faculty Publications

Highly effective antiretroviral-based HIV prevention plays an important role in ending the global HIV/AIDS epidemic. However, the sustainable control of the epidemic is hampered by unequal access to prevention options, including HIV testing, alongside with drug resistance and ongoing barriers to accessing sustainable HIV treatment. Therefore, an HIV vaccine, combined with effective prevention and treatment, remains an absolute necessity to control the epidemic. Yet, the recent discontinuation of four major vaccine efficacy studies is raising concerns about the future of HIV vaccine research and development globally, and particularly in the European region where funding for vaccine research and development has …