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2025

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Full-Text Articles in Medicine and Health Sciences

Addressing The Needs Of Jewish Clients And Students Through A Trauma-Informed Approach, Amiya Waldman-Levi, Robin Akselrud, Zahava L. Friedman, Lola Halperin, Shifra K. Leiser, Rivka Molinsky Jan 2025

Addressing The Needs Of Jewish Clients And Students Through A Trauma-Informed Approach, Amiya Waldman-Levi, Robin Akselrud, Zahava L. Friedman, Lola Halperin, Shifra K. Leiser, Rivka Molinsky

The Open Journal of Occupational Therapy

The worldwide Jewish community is notoriously nomadic because of persecution and displacement through several millennia. The diasporic experience of global Jewish communities led to traumatic events such as historical expulsion and genocide. These experiences embody all five components of occupational injustice. The recent rise in antisemitism has triggered intergenerational trauma among individuals, families, and communities. This paper, grounded in trauma-based research, aims to guide occupational therapists treating Jewish clients and/or teaching Jewish students. The paper outlines trauma-informed implications for therapist-client collaboration in the context of supporting occupational justice for diverse populations. The distinct role of occupational therapists in effectively serving …


Openness To Critique Is Essential, Brenda L. Beagan, Niki Kiepek, Heidi Lauckner, Paula W. Rushton Jan 2025

Openness To Critique Is Essential, Brenda L. Beagan, Niki Kiepek, Heidi Lauckner, Paula W. Rushton

The Open Journal of Occupational Therapy

No abstract provided.


Establishing Reliability And Validity For A Professional Development Tool For Graduate Health Care Programs, Lisa Handler, Amiya Waldman-Levi Jan 2025

Establishing Reliability And Validity For A Professional Development Tool For Graduate Health Care Programs, Lisa Handler, Amiya Waldman-Levi

The Open Journal of Occupational Therapy

Professional development ensures practitioners develop the necessary skills to succeed in multifaceted clinical roles. To provide evidence-based best practices, health practitioners need to possess critical thinking, executive functioning, and emotional intelligence skills. Study aimed to establish psychometric properties to the Inventory of Professional and Academic Reasoning (IPAR). Two cross-sectional studies of reliability and validity were used. The participants included 139 health profession students, of which 93 students participated in the first study and 46 occupational therapy students participated in the second study. Data were collected online and at fieldwork sites using a background questionnaire, IPAR, Executive Function Index, and the …


From Theory To Practice: Integrating Safe Patient Handling And Mobility Into Occupational Therapy Curriculum (Part 2/2), Kimberly Santorufo, Asha Roy Jan 2025

From Theory To Practice: Integrating Safe Patient Handling And Mobility Into Occupational Therapy Curriculum (Part 2/2), Kimberly Santorufo, Asha Roy

The Open Journal of Occupational Therapy

Occupational therapy academic institutions continue to teach manual patient handling as the standard of practice despite recent evidence, legislation, and guidelines from the American Occupational Therapy Association on hazards of manual approaches. A paradigm shift is necessary in occupational therapy academic curriculums to include didactic education and hands-on training of safe patient handling and mobility informed approaches. There is currently no standard of practice available in occupational therapy education on how to incorporate safe patient handling and mobility into preexisting curriculum, which emphasizes manual patient handling as the standard of care. The guidelines presented offer academic institutions recommendations on how …


From Theory To Practice: Integrating Safe Patient Handling And Mobility Into Occupational Therapy Curriculum (Part 1/2), Kimberly Santorufo, Asha Roy Jan 2025

From Theory To Practice: Integrating Safe Patient Handling And Mobility Into Occupational Therapy Curriculum (Part 1/2), Kimberly Santorufo, Asha Roy

The Open Journal of Occupational Therapy

Occupational therapists are at high-risk of musculoskeletal injury because of the manual and physical demands of job-related tasks. Many occupational therapists are sustaining injuries or changing careers because of an injury. Safe patient handling and mobility approaches should be used in occupational therapy practice to ensure the safety of both patient and therapist while assisting patients in meeting occupation-based and patient-centered goals. However, despite legislation, guidelines from the American Occupational Therapy Association, and recent evidence, most occupational therapy academic programs and educators continue to teach manual patient handling as the standard of practice. To ensure safety, longevity, and career-retention, academic …


Professional Behaviors As Forced Assimilation: A Critical Reflection On The U.S. History Of Education And Beyond, Quinn P. Tyminski, Karla Reese, Linn Wakeford Jan 2025

Professional Behaviors As Forced Assimilation: A Critical Reflection On The U.S. History Of Education And Beyond, Quinn P. Tyminski, Karla Reese, Linn Wakeford

The Open Journal of Occupational Therapy

Historically, education has been used as a mechanism of assimilation for marginalized identities in the United States, demanding conformity to the dominant culture and society. The occupational therapy (OT) profession is not immune and must examine and understand how our educational systems have erected and maintained barriers designed to exclude people from historically minoritized communities through the lens of professional behaviors. Professionalism and professional behaviors are not well-defined constructs in OT, and there is significant variability among educational institutions in how professional behavior standards are written, communicated, and applied. There is significant inconsistency across OT educational programs in the US …


An Academic Self-Regulation Program For First-Generation Students In Occupational Therapy: A Preexperimental Study, Pola Ham Jan 2025

An Academic Self-Regulation Program For First-Generation Students In Occupational Therapy: A Preexperimental Study, Pola Ham

The Open Journal of Occupational Therapy

First-generation students at U.S. universities have lower academic performance than their continuing-generation counterparts. They also have a lower level of academic self-regulation and academic self-efficacy. Bandura’s social cognition theory and Zimmerman’s self-regulation theory were used as theoretical frameworks to guide an intervention program relating to self-efficacy and self-regulation. A pretest and posttest survey measured changes in the participants’ use of the academic self-regulatory strategies and level of confidence in using those strategies. An open-ended questionnaire provided a detailed account of the participants’ lived experiences of the program. The researcher-facilitator designed an academic self-regulation program using Zimmerman’s (1998) self-regulated learning framework …


Comprehensive Breast Cancer-Related Lymphedema Management Programs Addressing Both Psychosocial And Physical Needs: A Scoping Review, Amanda Wheeler, Claudine Campbell, Chenchen Cui Jan 2025

Comprehensive Breast Cancer-Related Lymphedema Management Programs Addressing Both Psychosocial And Physical Needs: A Scoping Review, Amanda Wheeler, Claudine Campbell, Chenchen Cui

The Open Journal of Occupational Therapy

Background: Breast cancer is the leading cause of female cancer worldwide, which can lead to many negative sequelae, with up to a third of women developing breast cancer-related lymphedema. Breast cancer-related lymphedema requires chronic maintenance and is associated with worse physical and mental health outcomes compared to women without lymphedema. Occupational therapists are well-positioned to address the complex needs of women with breast cancer-related lymphedema. This review aimed to identify existing research that reports outcomes of lymphedema management programs addressing both physical and mental health needs of women with breast cancer-related lymphedema.

Method: A scoping review was conducted …


Linking The International Classification Of Functioning, Disability And Health (Icf) To Occupational Therapy Skilled Nursing Home Interventions, Janel Anne Belarmino, Laura Novak, Vanessa D. Jewell Jan 2025

Linking The International Classification Of Functioning, Disability And Health (Icf) To Occupational Therapy Skilled Nursing Home Interventions, Janel Anne Belarmino, Laura Novak, Vanessa D. Jewell

The Open Journal of Occupational Therapy

Background: Rehabilitation practitioners use the ICF as a framework to guide clinical decision-making, demonstrate the focus of interventions, and bridge interprofessional communication. The aim of this study was to examine occupational therapy interventions implemented with older adults for short term rehabilitation in skilled nursing facilities and link the interventions to the ICF.

Method: Through secondary analysis of previously collected field notes of skilled nursing facility occupational therapy interventions, the researchers linked 60 interventions to 133 third level ICF categories.

Results: Of the 133 categories, 62% (n = 82) were linked to Activities and Participation, 23% (n = 31) were …


The Lived Experience Of Therapists During The Covid-19 Pandemic: A Qualitative Study Using Photovoice Methodology, Alison De La Montaigne, Catana Brown, Sarah A. Anderson, Tamara Turner Jan 2025

The Lived Experience Of Therapists During The Covid-19 Pandemic: A Qualitative Study Using Photovoice Methodology, Alison De La Montaigne, Catana Brown, Sarah A. Anderson, Tamara Turner

The Open Journal of Occupational Therapy

Background: The purpose of this study was to explore the experience of therapists during the COVID-19 pandemic.

Method: A qualitative phenomenological design using photovoice methodology for collecting data was used (Wang & Burris, 1997). The study participants included twelve therapists. Using photovoice methodology, the participants used a picture to represent their experience and wrote an accompanying narrative to address the question, “How has COVID-19 impacted your life?” Thematic analysis was used to code and develop themes for the participant photovoices and the virtual focus group transcripts (Braun & Clark, 2006). Zoom was used as the virtual platform for the virtual …


An Occupational Therapy Work-Self-Efficacy Intervention For Lgbtq+ Young People In Transitional Housing, Emily K. Simpson, Monika I. Robinson Jan 2025

An Occupational Therapy Work-Self-Efficacy Intervention For Lgbtq+ Young People In Transitional Housing, Emily K. Simpson, Monika I. Robinson

The Open Journal of Occupational Therapy

Background: Lesbian, gay, bisexual, transgender, and queer (LGBTQ+) young people who are unhoused experience barriers transitioning into adult roles and responsibilities which negatively impacts workforce participation.

Methods: The purpose of this pilot study was to examine the impact of a work self-efficacy intervention on self-efficacy and goal attainment in LGBTQ+ young people at a transitional living facility (TLF). Nine residents and three staff participated in this convergent mixed methods design investigating a work intervention.

Results: The total median score on the General Self-Efficacy Scale (p = 0.042) and the Work Self-Efficacy Scale (p = 0.043) …


How Acute Care And Inpatient Occupational Therapists Describe Their Experiences With Secondary Traumatic Stress, Julie Suto, Ashley E. Lane, Rocio Torres, Emily K. Simpson Jan 2025

How Acute Care And Inpatient Occupational Therapists Describe Their Experiences With Secondary Traumatic Stress, Julie Suto, Ashley E. Lane, Rocio Torres, Emily K. Simpson

The Open Journal of Occupational Therapy

Background: The primary purpose of this research was to explore how occupational therapists in acute care and inpatient rehabilitation settings describe their experiences of secondary traumatic stress (STS).

Methods: Researchers used a convergent parallel mixed methods design. Electronic surveys (n = 181) and qualitative data collection through interviews (n = 6) and a focus group (n = 3) were used. Qualitative data were analyzed with content analysis, and quantitative data were analyzed using descriptive statistics. Both data sets were compared to identify patterns.

Results: Five main categories were identified: (a) supports to worker role, (b) barriers to worker role, (c) …


A Multisensory, Interdisciplinary Approach To Visual Neglect For Enhancement Of Visual Attention Following Basal Ganglia Hemorrhage: A Case Report, Leah G. Allan Jan 2025

A Multisensory, Interdisciplinary Approach To Visual Neglect For Enhancement Of Visual Attention Following Basal Ganglia Hemorrhage: A Case Report, Leah G. Allan

The Open Journal of Occupational Therapy

Background: This case report provides a review of the medical background and inpatient rehabilitation course of a 41-year-old female presenting with right basal ganglia hematoma in the setting of hypertension and polysubstance use. Emphasis is placed on analysis and discussion of the interdisciplinary, multisensory therapy approaches used to address her visual neglect and homonymous hemianopia.

Method: Single-patient case report

Results: On the Disability Rating Scale, the patient’s score improved from a Day 16 score of 10 to a Day 58 score of 7. On the Modified Barthel Index, her performance improved from a Day 16 score of …


Psychosocial Occupational Therapy Interventions For Pediatric Traumatic Brain Injury: A Scoping Review, Sabina Khan, Christianah Edema Jan 2025

Psychosocial Occupational Therapy Interventions For Pediatric Traumatic Brain Injury: A Scoping Review, Sabina Khan, Christianah Edema

The Open Journal of Occupational Therapy

Background: We aimed to examine the psychosocial interventions used by occupational therapists in managing pediatric TBI, and to identify unique psychosocial needs in this population.

Methods: The scoping review was guided by Arksey and O'Malley's framework. Four databases were searched for relevant studies namely: Embase (Elsevier), Medline (PubMed), Cochrane Library, and PsycNet. Included studies were studies written in English reporting on psychosocial interventions for pediatric TBI by occupational therapists and/or the psychosocial needs of children with TBI.

Results: The search identified 13 relevant studies published from 2006 to 2020. Multiple psychosocial interventions were pinpointed in these studies, …


Exploring The Relationship Between Handwriting Legibility And Praxis In Third And Fourth Grade Students, Denise K. Donica, Larymi Beck, Kathryn Mumford Jan 2025

Exploring The Relationship Between Handwriting Legibility And Praxis In Third And Fourth Grade Students, Denise K. Donica, Larymi Beck, Kathryn Mumford

The Open Journal of Occupational Therapy

Background. Research suggests praxis and sensory integration contributes to handwriting legibility in primary students. However, little research has demonstrated performance-based measures of praxis and its relationship to handwriting legibility. This study examined performance-based praxis skills of third and fourth grade students with and without handwriting difficulties (HD).

Method: Handwriting legibility and praxis were examined in 33 third and fourth grade students at a local primary school using the Handwriting Legibility Scale and five praxis tests from the Evaluation in Ayres Sensory Integration. Participants were categorized into two groups based on their handwriting legibility scores: students with HD (n = 6) …


State Of The Journal: The Importance Of Human Occupation, Diane Powers Dirette Jan 2025

State Of The Journal: The Importance Of Human Occupation, Diane Powers Dirette

The Open Journal of Occupational Therapy

No abstract provided.


Psychometric Development Of Scales Measuring Attitudes About And Interest In Integrated Healthcare Clinical Practice, Mark Cassano, Robert A. Ditomasso, Barbara A. Golden, Scott D. Glassman Jan 2025

Psychometric Development Of Scales Measuring Attitudes About And Interest In Integrated Healthcare Clinical Practice, Mark Cassano, Robert A. Ditomasso, Barbara A. Golden, Scott D. Glassman

The Journal of Integrated Primary Care

The landscape of integrated healthcare models continues to evolve, and with these changes, providers are facing the challenge of adopting approaches to care that may not have been taught in their training. With interprofessional education on the rise, some providers often struggle to modify their clinical methodology to accommodate an interdisciplinary team-based care format. In an effort to better understand the attitudes and interest levels that may affect a provider’s engagement in these models of care, the Integrated Health Attitudes and Interest Scales were developed. Using a best practices model, items for the measure were created by the investigators and …


Notalgia Paresthetica: Case Report, Emily M. Garelick, David Kasper Jan 2025

Notalgia Paresthetica: Case Report, Emily M. Garelick, David Kasper

The Journal of Integrated Primary Care

Notalgia paresthetica (NP) is a dermatologic condition that causes pruritus of the skin on the medial border of the inferior scapula and/or upper back. It is a chronic neurologic dysesthesia caused by pain from nerve fiber damage at the thoracic spine, levels two to six. Patients can also experience paresthesia, allodynia, and pruritus that is exacerbated by heat. It has been shown in multiple case reports that thoracic nerve impingement could be responsible for this problem, specifically herniated intervertebral discs, vertebral changes, and osteoarthritic lesions. Multiple methods of treatment have been reported to be effective including topical steroids and anesthetics, …


Prospective Receptivity And Acceptability Of Brief Alcohol Interventions Among Women And Racial/Ethnic Minority Veterans In Primary Care, Jacob L. Scharer, Robyn Shepardson, Brandi Roelk, Julie C. Gass, Laura Wray, Stephen A. Maisto, Jennifer Funderburk Jan 2025

Prospective Receptivity And Acceptability Of Brief Alcohol Interventions Among Women And Racial/Ethnic Minority Veterans In Primary Care, Jacob L. Scharer, Robyn Shepardson, Brandi Roelk, Julie C. Gass, Laura Wray, Stephen A. Maisto, Jennifer Funderburk

The Journal of Integrated Primary Care

Brief alcohol interventions (BAIs) are an evidence-based practice for addressing hazardous drinking among primary care patients, yet implementation of BAIs in practice has been difficult and disparities have been identified regarding implementing BAIs with women and racial/ethnic minority patients. Further, patient engagement is a commonly identified barrier to BAI implementation. This mixed methods study aimed to assess acceptability of BAIs among women and racial/ethnic minority primary care patients and to identify factors that may impact their receptivity to engaging in a BAI. Qualitative interviews were conducted with 17 patients who had screened positive for hazardous alcohol use. Patients reported neutral …


Improving Patient Engagement Through Whole Health: Veteran Perspectives On A Values Assessment Tool, Luke D. Mitzel, Robyn Shepardson, Emily M. Johnson, Jennifer Funderburk Jan 2025

Improving Patient Engagement Through Whole Health: Veteran Perspectives On A Values Assessment Tool, Luke D. Mitzel, Robyn Shepardson, Emily M. Johnson, Jennifer Funderburk

The Journal of Integrated Primary Care

Amidst rising rates of costly chronic diseases, a growing emphasis for integrated primary care settings is offering proactive, person-centered, and whole-person care. Through its Whole Health approach, the Veterans Health Administration (VA) is a leading force in this movement. VA’s Whole Health focuses on delivering patient-centered care that engages and empowers Veterans to improve health outcomes. The Personal Health Inventory (PHI) is a brief, whole-person focused, values assessment of what matters most that can lead to personalized health planning. Using a concurrent triangulation (convergent) mixed methods design, we examined the perspectives of 25 post-9/11 Veterans using semi-structured telephone interviews. Qualitative …


January 15, 2025 — Welcome Letter To Members Of The 119th Congress, American Dental Association Jan 2025

January 15, 2025 — Welcome Letter To Members Of The 119th Congress, American Dental Association

Advocacy in Action letters

No abstract provided.


Pharmacotherapeutic Efficacy Of Astaxanthin Toward Breast Cancer: A Systematic Review, Harnd Abdullah Ali, Bushra Hassan Marouf, Lanja Ibraheim Saeed, Rafl M. Kamil, Savan Mohammed Dilshad Jan 2025

Pharmacotherapeutic Efficacy Of Astaxanthin Toward Breast Cancer: A Systematic Review, Harnd Abdullah Ali, Bushra Hassan Marouf, Lanja Ibraheim Saeed, Rafl M. Kamil, Savan Mohammed Dilshad

BioMed Visions Journal

Background: Breast cancer (BC) is one of the most common malignancies in women, characterized by the malignant proliferation of breast epithelial cells that significantly impairs patients’ quality of life. Astaxanthin (ASN), a marine-derived xanthophyll carotenoid, is known for its antioxidant and anti-inflammatory properties. Emerging evidence suggests that ASN may exert anti-neoplastic effects by inhibiting tumorigenesis and suppressing the growth and progression of BC cells. This systematic review aims to critically evaluate the therapeutic potential of ASN as a pharmacological agent in the prevention and management of breast cancer.

Methodology: Following PRISMA 2020 guidelines, a comprehensive literature search was conducted in …


Insights Into Mesiodistal Teeth Alignment In Angle Class I And Ii Malocclusions Via Panoramic Radiographs, Mcqueen Mendonca Jan 2025

Insights Into Mesiodistal Teeth Alignment In Angle Class I And Ii Malocclusions Via Panoramic Radiographs, Mcqueen Mendonca

Annual Research Symposium

Knowledge of mesiodistal angulation of the teeth is a crucial aspect at various stages of orthodontic treatment and planning. Hence, it’s important to assess the mesiodistal angulation of the teeth using panoramic radiograph and also reinforce it by clinical examination of the dentition.


Detection Of Elder Abuse Through Emergency Care Technicians Screening Tool Revision For Home-Based Primary Care (Detect-Rpc): A Cluster Randomised Controlled Trial Study Protocol, Brad Cannell, Nicholas Sevey, Melvin D Livingston, Jason Burnett, Kristin Lees Haggerty, Carolyn Pickering Jan 2025

Detection Of Elder Abuse Through Emergency Care Technicians Screening Tool Revision For Home-Based Primary Care (Detect-Rpc): A Cluster Randomised Controlled Trial Study Protocol, Brad Cannell, Nicholas Sevey, Melvin D Livingston, Jason Burnett, Kristin Lees Haggerty, Carolyn Pickering

Faculty, Staff and Student Publications

Introduction: The annual prevalence of elder mistreatment (EM) in cognitively intact older adults is estimated to be 11%, yet the annual prevalence in older adults with Alzheimer's disease and related dementias (AD/ADRD) is estimated to be as high as 75%. Associated with a decrease in quality of life and increase in risk of mortality, EM represents a significant public health burden. Home-based primary care (HBPC) providers are uniquely positioned to address the critical need for robust EM screening and reporting, especially among individuals with AD/ADRD. This protocol seeks to adapt the Detection of Elder mistreatment Through Emergency Care Technicians (DETECT) …


Awareness Of Epinephrine Pen Use Among Students Of Faculty Of Applied Medical Sciences At Umm Al Qura University, Saudi Arabia 2024, Ahmed Ali Shammah Jan 2025

Awareness Of Epinephrine Pen Use Among Students Of Faculty Of Applied Medical Sciences At Umm Al Qura University, Saudi Arabia 2024, Ahmed Ali Shammah

Saudi Toxicology Journal

Introduction: Anaphylaxis is a dangerous hypersensivity reaction that is characterised by generalised allergic response. Epinephrine is significant treatment for managing anaphylaxis. Moreover, epinephrine pens consider important first-aid kits in universities. Background and Aims: This research aims to explore awareness and usage of epinephrine pen between the student in faculty of Applied Medical Science, Umm Al-Qura University, Saudi Arabia and to explore their practices and knowledge in anaphylaxis management. Methodology: A cross-sectional study conducted using a structured questionnaire distributed to students across various departments and academic years within the faculty. A quota sampling method employed to ensure diverse representation. Data were …


Adenosine-Sensitive Upper Septal Fascicular Ventricular Tachycardia Associated With Takotsubo Syndrome, Parker O'Neill, Daniel Underberg, Reginald Ho, Darius Farzad, Gregary Marhefka Jan 2025

Adenosine-Sensitive Upper Septal Fascicular Ventricular Tachycardia Associated With Takotsubo Syndrome, Parker O'Neill, Daniel Underberg, Reginald Ho, Darius Farzad, Gregary Marhefka

Department of Medicine Faculty Papers

We describe a rare case of upper septal fascicular ventricular tachycardia (VT) associated with takotsubo syndrome that failed to convert with synchronized shock but converted to normal sinus rhythm after intravenous adenosine administration. The excess catecholamine state of takotsubo syndrome likely provided substrate for cyclic adenosine monophosphate–mediated triggered activity, causing fascicular VT.


Adverse Childhood Experiences: Healing Through Storytelling And Mindful Narrative Therapy, Julie Kemp Jan 2025

Adverse Childhood Experiences: Healing Through Storytelling And Mindful Narrative Therapy, Julie Kemp

Mindfulness Studies Theses

This study presents research about the nature and prevalence of adverse childhood experiences (ACEs), the mental and physical impacts to individuals exposed to ACEs, and incorporating mindfulness practices into therapeutic approaches to treating them, particularly Mindfulness-Based Narrative Therapy (MBNT). It is important because ACEs have become a global crisis, with the potential for interfering with psychological and physical development, early mortality, and other harmful life outcomes. This thesis provides critical information for mindfulness teachers and practitioners, therapists, educators, regulators, parents, and individuals subjected to ACEs.

The methodology includes extensive literature searches for narrative therapy and mindfulness-based interventions (MBIs) in peer-reviewed …


The Big Five Personality Traits And Eating Habits Among Female Students At Zayed University, Sharifa Alblooshi, Kawther Alsabbah, Shatha Thani, Rafiq Hijazi, Ayesha S. Al Dhaheri, Falak Zeb, Leila Cheikh Ismail Jan 2025

The Big Five Personality Traits And Eating Habits Among Female Students At Zayed University, Sharifa Alblooshi, Kawther Alsabbah, Shatha Thani, Rafiq Hijazi, Ayesha S. Al Dhaheri, Falak Zeb, Leila Cheikh Ismail

All Works

Adhering to healthy dietary habits is crucial for disease prevention and improving overall quality of life. Understanding how personality traits influence eating behaviors is essential for developing effective interventions aimed at promoting healthier eating habits. Personality traits are consistent behavioral patterns that individuals typically exhibit, and the Five-Factor Model (also known as the Big Five) is widely recognized as an effective framework for predicting personality traits. This study analyzed the relationship between personality traits and eating behaviors among 425 female students using a cross-sectional design. Sociodemographic data and personality traits were assessed using an online questionnaire, while eating behaviors were …


Targeting Cytokine-Mediated Inflammation In Brain Disorders: Developing New Treatment Strategies, Rahul Mallick, Sanjay Basak, Premanjali Chowdhury, Ranjit Kumar Das, Antara Banerjee, Sujay Paul, Surajit Pathak, Asim K. Duttaroy Jan 2025

Targeting Cytokine-Mediated Inflammation In Brain Disorders: Developing New Treatment Strategies, Rahul Mallick, Sanjay Basak, Premanjali Chowdhury, Ranjit Kumar Das, Antara Banerjee, Sujay Paul, Surajit Pathak, Asim K. Duttaroy

Health & Biomedical Sciences Faculty Publications

Cytokine-mediated inflammation is increasingly recognized for playing a vital role in the pathophysiology of a wide range of brain disorders, including neurodegenerative, psychiatric, and neurodevelopmental problems. Pro-inflammatory cytokines such as interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) cause neuroinflammation, alter brain function, and accelerate disease development. Despite progress in understanding these pathways, effective medicines targeting brain inflammation are still limited. Traditional anti-inflammatory and immunomodulatory drugs are effective in peripheral inflammatory illnesses. Still, they face substantial hurdles when applied to the central nervous system (CNS), such as the blood–brain barrier (BBB) and unwanted systemic effects. This review highlights the …


A Guinea Pig Model Of Pediatric Metabolic Dysfunction-Associated Steatohepatitis: Poor Vitamin C Status May Advance Disease, Kamilla Pedersen, Ankita Poojari, Simone F. Colberg, Stine M. Mechernsee, Jo F. Iversen, Romain Barrès, Jens Lykkesfeldt, Pernille Tveden-Nyborg Jan 2025

A Guinea Pig Model Of Pediatric Metabolic Dysfunction-Associated Steatohepatitis: Poor Vitamin C Status May Advance Disease, Kamilla Pedersen, Ankita Poojari, Simone F. Colberg, Stine M. Mechernsee, Jo F. Iversen, Romain Barrès, Jens Lykkesfeldt, Pernille Tveden-Nyborg

Pacific Faculty Work

Background/Objectives: Children and teenagers display a distinct metabolic dysfunction-associated steatohepatitis (MASH) phenotype, yet studies of childhood MASH are scarce and validated animal models lacking, limiting the development of treatments. Poor vitamin C (VitC) status may affect MASH progression and often co-occurs with high-fat diets and related metabolic imbalances. As a regulator of DNA methylation, poor VitC status may further contribute to MASH by regulating gene expression This study investigated guinea pigs—a species that, like humans, depends on vitC in the diet—as a model of pediatric MASH, examining the effects of poor VitC status on MASH hallmarks and global DNA methylation …