Lifespan In Rodents With Myt1l Heterozygous Mutation, Allyson Schreiber, Raylynn G Swift, Leslie Wilson, Kristen L Kroll, Joseph D Dougherty, Susan E Maloney

2020-Current year OA Pubs

MYT1L syndrome is a newly recognized disorder characterized by intellectual disability, speech and motor delay, neuroendocrine disruptions, ADHD, and autism. In order to study this gene and its association with these phenotypes, our lab recently created a Myt1l heterozygous mutant mouse inspired by a clinically relevant mutation. This model recapitulates several of the physical and neurologic abnormalities seen in humans with MYT1L syndrome, such as weight gain, microcephaly, and behavioral disruptions. The majority of patients with this syndrome are young, and little is known about the impact of age on health and mortality in these patients. Using a Myt1l mutant …

A Neuronal Code For Object Representation And Memory In The Human Amygdala And Hippocampus, Runnan Cao, Peter Brunner, Puneeth N Chakravarthula, Krista L Wahlstrom, Cory Inman, Elliot H Smith, Xin Li, Adam N Mamelak, Nicholas J Brandmeir, Ueli Rutishauser, Jon T Willie, Shuo Wang

2020-Current year OA Pubs

How the brain encodes, recognizes, and memorizes general visual objects is a fundamental question in neuroscience. Here, we investigated the neural processes underlying visual object perception and memory by recording from 3173 single neurons in the human amygdala and hippocampus across four experiments. We employed both passive-viewing and recognition memory tasks involving a diverse range of naturalistic object stimuli. Our findings reveal a region-based feature code for general objects, where neurons exhibit receptive fields in the high-level visual feature space. This code can be validated by independent new stimuli and replicated across all experiments, including fixation-based analyses with large natural …

Enhancing Progestin Therapy With A Glucagon-Like Peptide 1 Agonist For The Conservative Management Of Endometrial Cancer, Andrea R Hagemann, Ian S Hagemann, David G Mutch, Eric J Devor, Paige K Malmrose, Yuping Zhang, Abigail M Morrison, Kristina W Thiel, Kimberly K Leslie

2020-Current year OA Pubs

OBJECTIVE: Obesity is a major risk factor for endometrial cancer. In addition to hormone therapy with progestins, glucagon like peptide-1 receptor (GLP-1R) agonists such as semaglutide may be helpful to achieve weight loss during conservative treatment of endometrial hyperplasia or cancer.

METHODS: We theorized that the combination of semaglutide and the progestin levonorgestrel would be useful as a novel treatment or prevention regimen and tested this hypothesis using endometrial cancer cell lines and patient-derived organoids (PDOs).

RESULTS: Hec50, KLE, and Ishikawa endometrial cancer cells express GLP-1R, as determined by both qPCR and Western blotting, and GLP-1R agonist treatment induces GLP-1R …

Swog S1815: A Phase Iii Randomized Trial Of Gemcitabine, Cisplatin, And Nab-Paclitaxel Versus Gemcitabine And Cisplatin In Newly Diagnosed, Advanced Biliary Tract Cancers, Rachna T Shroff, Benjamin Tan, Et Al.

2020-Current year OA Pubs

PURPOSE: SWOG S1815 was a randomized, open label phase III trial, evaluating gemcitabine, nab-paclitaxel, and cisplatin (GAP) versus gemcitabine and cisplatin (GC) in patients with newly diagnosed advanced biliary tract cancers (BTCs).

METHODS: Patients with newly diagnosed locally advanced unresectable or metastatic BTC, including intrahepatic cholangiocarcinoma (ICC) and extrahepatic cholangiocarcinoma (ECC) and gallbladder carcinoma (GBC), were randomly assigned 2:1 to either GAP (gemcitabine 800 mg/m

RESULTS: Among 452 randomly assigned participants, 441 were eligible and analyzable, 67% with ICC, 16% with GBC, and 17% with ECC. There was no significant difference in overall survival (OS) between GAP versus GC. Median …

Long-Read Sequencing Of 945 Han Individuals Identifies Structural Variants Associated With Phenotypic Diversity And Disease Susceptibility, Jiao Gong, Huiru Sun, Kaiyuan Wang, Yanhui Zhao, Yechao Huang, Qinsheng Chen, Hui Qiao, Yang Gao, Jialin Zhao, Yunchao Ling, Ruifang Cao, Jingze Tan, Qi Wang, Yanyun Ma, Jing Li, Jingchun Luo, Sijia Wang, Jiucun Wang, Guoqing Zhang, Shuhua Xu, Feng Qian, Fang Zhou, Huiru Tang, Dali Li, Chinese Pangenome Consortium (Cpc), Fritz J Sedlazeck, Li Jin, Yuting Guan, Shaohua Fan

Faculty, Staff and Students Publications

Genomic structural variants (SVs) are a major source of genetic diversity in humans. Here, through long-read sequencing of 945 Han Chinese genomes, we identify 111,288 SVs, including 24.56% unreported variants, many with predicted functional importance. By integrating human population-level phenotypic and multi-omics data as well as two humanized mouse models, we demonstrate the causal roles of two SVs: one SV that emerges at the common ancestor of modern humans, Neanderthals, and Denisovans in GSDMD for bone mineral density and one modern-human-specific SV in WWP2 impacting height, weight, fat, craniofacial phenotypes and immunity. Our results suggest that the GSDMD SV could …

Red Meat Consumption And Hypertension: An Updated Review, Tara S Allen, Michael Najem, Alexis C Wood, Danielle J Lee, Lorena S Pacheco, Lori B Daniels, Matthew A Allison

Faculty, Staff and Students Publications

PURPOSE OF REVIEW: Hypertension (HTN) is a major risk factor for cardiovascular diseases (CVD). The global prevalence of HTN and related CVD mortality continues to rise. The development of HTN is influenced by genetic predisposition and modifiable risk factors, including diet. One area of ongoing debate is the relationship between red meat consumption and risk of HTN.

RECENT FINDINGS: Processed red meat has become increasingly implicated in the pathogenesis and morbidity of HTN, though randomized control trials comparing HTN-related outcomes associated with red meat subtypes have yielded heterogenous results. This review summarizes the existing relevant literature and highlights the methodological …

Contrast-Enhanced Magnetic Resonance Imaging Based Calf Muscle Perfusion And Machine Learning In Peripheral Artery Disease, Bijen Khagi, Tatiana Belousova, Christina M Short, Addison A Taylor, Jean Bismuth, Dipan J Shah, Gerd Brunner

Faculty, Staff and Students Publications

Peripheral artery disease (PAD) remains underdiagnosed and undertreated and is associated with an increased risk for adverse cardiovascular outcomes. Imaging provides an approach to identifying patients with PAD. However, the role of integrating imaging with machine learning to identify PAD patients and potentially assess disease severity remains understudied. A total of 56 participants, including 36 PAD patients with intermittent claudication and 20 matched controls, underwent contrast-enhanced magnetic resonance imaging (CE-MRI) calf muscle perfusion scanning. CE-MRI-derived dynamic muscle perfusion maps were developed to quantify alterations of the microvascular circulation in the calf muscles based on voxel contrast enhancement. These dynamic muscle …

A Targeted Gene Expression Biomarker Predicts Clinic Low-Risk Meningioma Recurrence, Minh P Nguyen, Ramin A Morshed, Mark W Youngblood, Haley K Perlow, Calixto-Hope G Lucas, Akash J Patel, Joshua D Palmer, Craig M Horbinski, Stephen T Magill, William C Chen, David R Raleigh

Duncan NRI Faculty and Staff Publications

Background: Despite reassuring clinical and histological features, low-grade meningiomas can recur after surgery. Targeted gene expression profiling improves risk stratification of meningiomas, but the utility of this approach for clinical low-risk meningiomas is incompletely understood.

Methods: This was a multicenter retrospective cohort study of meningiomas from patients who were treated at 4 institutions from 1992 to 2023. Adult patients with newly diagnosed or recurrent World Health Organization (WHO) grade 1 meningiomas that were treated with gross total resection (GTR) or subtotal resection (STR), or newly diagnosed WHO grade 2 meningiomas that were treated with GTR, were included. A 34-gene expression …

Evaluation Of Glass Ionomer With Advanced Glass Hybrid Technology Versus Resin Modified Glass Ionomer In Adult Patients With Carious Cervical Lesions After One Year: A Randomized Clinical Trial., Aya Magdy Zayed, ِAhmed Zoheir El Hoshy, Mohamed Refaat El-Bialy

Future Dental Journal

Aim: Compared the clinical performance by using Advanced Glass Hybrid technology glass ionomer (AGH) in cervical carious lesion, versus resin modified glass ionomer (RMGI) according to modified USPHS criteria over one year. Materials and methods: An overall of 32 elevated carious index adult patients with at least one carious class V cavity on their posterior teeth had been split into 2 equal groups randomly based on the received restoration system. Two pairs of restorations were used, either; Equia Forte HT Fill (AGH) or Fuji II LC (RMGI), both materials were employed in accordance with the manufacturer's guidelines. Fillings have …

Bond Strength Of Thermally Aged Cad/Cam Hybrid Nanoceramic Repaired With Nanohybrid Resin Composite, Mostafa Aboushahba, Sara H. Younis

Future Dental Journal

Purpose. To assess shear bond strength (SBS) of nanohybrid resin composite used to repair CAD/CAM Hybrid Nanoceramic ceramic after various surface treatments.

Materials and Methods. SHOFU HC Hybrid Ceramic disks were sliced to obtain circular-shaped specimens (n= 30) were obtained. All specimens were thermocycled (5000 thermal cycles), then specimens were divided into three groups according to the surface treatment performed (sandblasting, HF acid etching, and laser irradiation) (n = 10). Repair procedure with nanohybrid resin composite was performed. SBS values were obtained, and failure modes were determined. Data were statistically analyzed (P ≤ 0.05). Results. The highest SBS …

Alterations Of Tnf-Α And Il-8 Levels In Gingival Crevicular Fluid Among Different Types Of Smoking Following Phase I Periodontal Therapy In Periodontitis Patients, Nouran Abdelmaged Dr., Nivine Ibrahim Ragy Professor, Zienab Farid Dr.

Future Dental Journal

Aim: The purpose of the current research was to evaluate the impacts of different smoking types on GCF levels of TNF-α & IL-8 after phase I periodontal therapy. The study compared between traditional cigarettes and heated tobacco products (HTPs) in contrast to non-smokers following non-surgical treatment of moderate periodontitis patients. Subjects & methods: Forty-five patients with moderate generalized chronic periodontitis had been enrolled in this research. They had been divided into 3 equal groups and received non-surgical periodontal treatment. Samples of gingival crevicular fluid had been collected from periodontal pockets at baseline & after six months. The collected …

Antibacterial Effect Of Silver Diamine Fluoride And Glass Ionomer Cement Restorations Against Streptococcus Mutans (An In Vitro Study), Shima Mahmoud Ibrahim Dr., Osama Ibrahim Elshahawy Prof Dr., Sara Ahmed Mahmoud Prof Dr., Eman Alaa Eldeen Abd Allah Associate Professor

Future Dental Journal

Objective: To determine the antibacterial effect of silver diamine fluoride and glass ionomer cement restoration against streptococcus mutans. Materials and methods: This study included 10 blood agar plates, the anti-bacterial efficacy of each matter was estimated against streptococcus mutans using agar diffusion test. Streptococcus mutans was prepared on blood gar plate. Three wells (A,B,C) with a diameter of 5 mm were performed in each plate and totally filled with one of the tested substances. The test materials were divided into three groups: group A (SDF): silver diamine fluoride, group B (GI): glass ionomer and group C (SDF+GI) were placed into …

Assessment Of Dental Anxiety And Fear In A Group Of Children And Adolescents With Molar Incisor Hypomineralisation (Mih), A Comparative Cross Sectional Study, Jumana Adel Alshafei, Osama Ibrahim El-Shahawy, Randa Youssef, Eman Alaa

Future Dental Journal

Introduction: patients with Molar Incisor Hypomineralisation are highly susceptible to caries and hypersensitivity because of the altered morphology and structure of the enamel prisms, which can result in complication in management during the treatment.

Aim: the aim of the study was to assess the Dental Fear and Anxiety in a group of Egyptian children and adolescents with MIH.

Subjects and methods: the study was a comparative cross-sectional study included 200 Egyptian children and adolescents aged from 6 to 17 years old ,100 patients diagnosed with MIH and 100 as a control group attending the Pediatric Dentistry and Dental Public Health …

Oral Health-Related Quality Of Life: A Cross-Sectional Comparison Between Dental And Non-Dental Students At Newgiza University, Fayrouz Sayed Saber, Mohamed Sabry, Alaa Nawar, Mayar El Weik

Future Dental Journal

Introduction: Evaluating oral health-related quality of life (OHRQoL) among Egyptian dental students can broaden the traditional focus on dental criteria to include social, emotional, and functional aspects. This perspective shift is vital as background knowledge influences both perceptions and behaviors regarding oral health. Comparing OHRQoL between dental and non-dental students is crucial for understanding these differences.

Aim: This study aims to compare the oral health related quality of life and oral hygiene measures between a group of dental and non-dental students at Newgiza University.

Methods: During the Oral Health Day at Newgiza University, the short form of the Oral …

Accuracy Of Dolphin Imaging Software Vs Quickceph Studio In Prediction Of The Extraction Treatment Outcomes Of Class Ii Malocclusion In Adult Patients: A Retrospective Study, Mostafa Ahmad Hashem, Hala Munir Abdel Majeed, Sameh Mohamed Talaat

Future Dental Journal

This study aimed to evaluate the accuracy of Dolphin Imaging Software and QuickCeph Studio in predicting the soft tissue profile following extraction treatment of Class II malocclusion. The study included 32 Class II patients aged 14 to 30 years who had previously undergone orthodontic treatment with extraction of first premolars. The accuracy of both software applications was evaluated using preoperative and postoperative lateral cephalometric X-rays and extra-oral photographs to compare the predicted outcomes with the actual post-treatment outcomes. Results: there was no significant difference between posttreatment and predicted regarding dolphin software while there was only a significant difference between posttreatment …

Scanning Electron Microscope Evaluation Of Enamel Damage After Bracket Debonding Using Two Techniques For Residual Resin Removal: (A Randomized Clinical Trial), Besher Maher Hawout Besher, Essam Nassef Prof. Dr., Hala Munir Prof. Dr., Faten Eid Prof. Dr.

Future Dental Journal

Introduction: The purpose of this study was evaluation of enamel damage index (EDI) immediately after adhesive removal and after exposure to intraoral fluids for a period of 3 months, using tungsten carbide burs compared to stainbuster burs.

Methods: Twenty patients were randomly assigned into 2 main groups 10 patients each, where in Group I the enamel damage index was evaluated immediately after adhesive removal and in Group II the enamel damage index was evaluated after 3 months follow up. Forty premolars in each group were randomly assigned to either TC bur or SB bur groups. In Group 2, replicas using …

P53 Tumor Suppressor Gene Expression In Ameloblastoma Subtypes: An Immunohistochemical Analysis, Yara Y. Mouselhy, Ahmed Abozekry, Iman M. Abdel Meguid, Raneem F. Obeid, Mai Abdelhalim Hamouda, Hala El-Kammar

Future Dental Journal

Background: Ameloblastoma is the most frequent of the benign epithelial odontogenic tumours. It exhibits a unique biologic behavior which demands meticulous understanding for thorough diagnosis and management. P53 tumor suppressor protein functions as a gatekeeper of cell division, inducing either cell cycle arrest or apoptosis. While mutations in the p53 gene are often detected in human cancers; the role of p53 in ameloblastoma remains elusive.

Material and methods: To investigate p53 expression in ameloblastoma, a retrospective study was designed to evaluate and compare immunohistochemical p53 protein expression patterns, in follicular ameloblastoma, plexiform ameloblastoma and unicystic ameloblastoma. Nine paraffin-embedded archival tissue …

Postoperative Pain After Different Root Canal Irrigant Activation Methods In Patients With Non-Vital Teeth (Randomized Clinical Trial), Passant Tarek El Zainy, Wael Ahmed Hessein Prof, Mahmoud Mohamed Badr

Future Dental Journal

Objective To evaluate the effect of ultrasonic irrigation or manual dynamic agitation on postoperative pain in patients with necrotic teeth with symptomatic apical periodontitis using (VAS) scale.

Methods Seventy-eight patients diagnosed with necrotic mandibular first molar with symptomatic apical periodontitis were randomly allocated into 1 of 3 separate groups (n=26); Manual Dynamic Agitation group, Ultra X group, or Navitip group (control). After a single visit root canal treatment and a specific method of agitation, depending on each group, the patients were given a questionnaire on which the patient would mark the degree of pain in a scale from 0 to …

The Effect Of Nanoparticles Incorporation On Antimicrobial And Bond Strength Properties Of Bio-Ceramic Sealer (An In Vitro Study), Hatem Tarek Dr., Wael Hussein Kamel Prof., Nehal Ezzat Sabet Prof., Adel Abdelwahed Associate Prof.

Future Dental Journal

Aim: This research intended to assess how the addition of nanoparticles impacts the antimicrobial effectiveness and bonding ability of bio-ceramic sealers when compared to resin-based sealers.. Materials and Methods: Bioactive glass nanoparticles (BG NPs) were prepared via a modified Stöber process. AH Plus and Bio-C Sealer were mixed with (BG NPs). Part I: Antibacterial tests involved 96 tubes divided into 6 main groups , tests were conducted using Enterococcus faecalis using direct contact test (DCT). Part II: Push-out tests utilized 32 extracted human permanent anterior teeth and were performed to evaluate bond strength. Results: Resin-based sealers and bio-ceramic sealers exhibited …

Assessing The Usefulness Of Solid-Phase Microextraction (Spme) For Methadone And Its Metabolites Analysis In Urine Samples Using Hplc/Spme Fibre Tips, Majidah Mahmoud Alfahmi

Saudi Toxicology Journal

Solid-phase microextraction (SPME) has been introduced as a novel, simple and single- step technique of extracting methadone (MDN), 2-ethylidene-1,5-dimethyl-3,3- diphenylpyrrolidine (EDDP) and 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline (EMDP) from urine samples. In this study, direct immersion SPME followed by high-performance liquid chromatography with ultraviolet detection (HPLC-UV) was developed to identify methadone and its metabolites. The separation was performed on a Gemini C18 (octadecyl carbon chain) analytical column (150 x 2.0 mm, 5 µm) and detected by an ultraviolet (UV) detector at 210 nm. The factors influencing the SPME procedure, such as the sample’s pH, fibre coating type, salt addition and desorption solvent type were …

Hidradenitis Suppurativa Is Associated With An Increased Risk Of Adverse Cardiac Events And All-Cause Mortality, Thomas Z. Rohan, Ramsay Hafer, Teresa Duong, Rishob Dasgupta, Sherry Yang

Department of Dermatology and Cutaneous Biology Faculty Papers

Background: Hidradenitis suppurativa (HS) has been previously associated with greater rates of major adverse cardiac events (MACEs) compared to the general population. This study aims to better elucidate the association between HS, MACEs, and other cardiovascular diseases. Methods: We utilized TriNetX, a global database of electronic health records, to conduct a retrospective cohort study. HS patients were matched on demographic and cardiovascular disease risk factors to both healthy and psoriasis groups as controls. Results: After adjusting for cardiovascular disease risk factors, HS patients had a relative risk (RR) (95% CI) of 2.06 (1.83-2.32) for myocardial infarction, 1.62 …

Neuronal Network Activation Induced By Forniceal Deep Brain Stimulation In Mice, Bin Tang, Zhenyu Wu, Qi Wang, Jianrong Tang

Faculty, Staff and Students Publications

Background: The fimbria-fornix is a nerve fiber bundle that connects various structures of the limbic system in the brain and plays a key role in cognition. It has become a major target of deep brain stimulation (DBS) to treat memory impairment in both dementia patients and animal models of neurological diseases. Previously, we have reported the beneficial memory effects of chronic forniceal DBS in mouse models of intellectual disability disorders. In Rett syndrome and CDKL5 deficiency disorder models, DBS strengthens hippocampal synaptic plasticity, reduces dentate inhibitory transmission or increases adult hippocampal neurogenesis that aids memory. However, the underlying neuronal circuitry …

Exploring The Relationship Between Psychiatric Illness And Dermatological Disorders: A Narrative Review, Alan D. Kaye, Rahib K. Islam, Abigayle M. Castine, Grace C. Wester, William T. Barham, Catherine G. Nguyen, Elena Plakotaris, Bradley Dorius, Julian Kim, Patricia Griffin, Amber Edinoff, Sahar Shekoohi, Giustino Varrassi

School of Medicine Faculty Publications

The interplay between psychiatric conditions and dermatological disorders is complex and multifaceted, often resulting in significant challenges for both diagnosis and treatment. This narrative review examines associations between specific psychiatric conditions, trichotillomania, attention deficit hyperactivity disorder, schizophrenia, bipolar disorder, and various dermatological disorders. The present investigation delves into pathophysiological mechanisms, clinical presentations, and management strategies of these comorbid conditions. Psychiatric disorders can exacerbate dermatological conditions through mechanical trauma, medication side effects, and stress-induced exacerbations, while dermatological disorders can lead to significant psychiatric morbidity. The biopsychosocial approach, emphasizing the importance of integrated care involving dermatologists and mental health professionals, is crucial …

Quantitative Characterization And Prediction Of The Binding Determinants And Immune Escape Hotspots For Groups Of Broadly Neutralizing Antibodies Against Omicron Variants: Atomistic Modeling Of The Sars-Cov-2 Spike Complexes With Antibodies, Mohammed Alshahrani, Vedant Parikh, Brandon Foley, Nishank Raisinghani, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

A growing body of experimental and computational studies suggests that the cross-neutralization antibody activity against Omicron variants may be driven by the balance and tradeoff between multiple energetic factors and interaction contributions of the evolving escape hotspots involved in antigenic drift and convergent evolution. However, the dynamic and energetic details quantifying the balance and contribution of these factors, particularly the balancing nature of specific interactions formed by antibodies with epitope residues, remain largely uncharacterized. In this study, we performed molecular dynamics simulations, an ensemble-based deep mutational scanning of SARS-CoV-2 spike residues, and binding free energy computations for two distinct groups …

Axillo-Caval Extra-Anatomic Venous Bypass Creation Via Direct Percutaneous Puncture Of The Superior Vena Cava, Stephan S. Leung, Patrick Lee, Anthony N. Hage, Robert W. Ford

Department of Radiology Faculty Papers

No abstract provided.

Trends Of Opioid Use Following Anterior Cervical Discectomy And Fusion: A 10-Year Longitudinal Study Of The Veterans Health Administration, Andrew M. Gabig, Paymon G. Rezaii, Sean C. Clark, Bela P. Delvadia, Olivia C. Lee, William F. Sherman, Mathew Cyriac

School of Medicine Faculty Publications

BACKGROUND: The United States Veteran Health Administration (VHA) cares for a substantial group of patients who are at higher risk of substance abuse in comparison to the general population. The purpose of this study was to (1) examine opioid consumption in the veteran population both pre- and postoperatively to anterior cervical discectomy and fusion (ACDF) and (2) understand the risk factors that are associated with sustained postoperative opioid use. METHODS: A retrospective database study was conducted using the Veterans Affairs Informatics and Computing Infrastructure database. Patients who underwent ACDF between 2010 and 2020 were identified and stratified into 3 groups …

Motor Pool Selectivity Of Neuromuscular Degeneration In Type I Spinal Muscular Atrophy Is Conserved Between Human And Mouse, Justin C Lee, Wendy K Chung, David J Pisapia, Christopher E Henderson

Faculty, Staff and Students Publications

Spinal muscular atrophy (SMA) is caused by low levels of the survival motor neuron (SMN) protein. Even though SMN is ubiquitously expressed, the disease selectively affects motor neurons, leading to progressive muscle weakness. Even among motor neurons, certain motor units appear more clinically resistant to SMA. To quantitatively survey selective resistance, we studied extensive neuromuscular autopsies of Type I SMA patients and age-matched controls. We found highly divergent degrees of degeneration of neighboring motor units, even within individual cranial nerves or a single anatomical area such as the neck. Examination of a Type I SMA patient maintained on life support …

Modeling Area Deprivation Index Using Non-Gaussian Fixed Rank Kriging, Edwin Kutsushi Mutimba

SDSU Data Science Symposium

The Area Deprivation Index (ADI) plays a vital role in identifying and addressing socioeconomic challenges, forming the basis for fair public health policies and resource distribution. This study explores the capabilities of both linear and non-linear statistical models, with a focus on Fixed Rank Kriging (FRK), to analyze ADI using data on U.S. Social Determinants of Health (SDOH). The model’s predictive capability is compared with Generalized Additive Models (GAM) and Generalized Additive Models for Location, Scale, and Shape (GAMLSS). The non-gaussian FRK provides a more comprehensive spatial analysis, albeit with higher computational requirements.

Machine Learning And Shap Interpretability For Chronic Disease Understanding, Nnaemeka Charles Igwe, Khandaker Mamun Ahmed

SDSU Data Science Symposium

Non-communicable diseases (NCDs), such as diabetes, are major global health concerns influenced by various health parameters and lifestyle choices. Traditional methods struggle to efficiently predict and manage these conditions due to the complexity and diversity of medical data. There is a need to leverage machine learning algorithms and modern computational tools to accurately predict diabetes, improve diagnosis, and provide actionable insights for better healthcare outcomes. In this project we study the application of machine learning methods for predicting NCDs such as diabetes. Moreover, we leverage hyperparameter tuning techniques for model development and SHapley Additive exPlanation (SHAP) for results interpretations and …

Artificial Intelligence (Ai) In Pharmacy, Giang Nguyen, Elizabeth Sartschev, John Reyes, Allie Honigford, Marisa Petrunich, Kiley Devoll, Brianna Lu, Joshua Honaker, T'Bony M. Jewell

Pharmacy and Wellness Review

Artificial Intelligence (AI) has transformed the pharmaceutical field by enabling computer software systems to learn and perform human behavior. Specifically, AI has revolutionized chronic diabetes management through continuous glucose monitoring, showcasing its immense potential in healthcare. However, alongside its transformative impact, AI’s increasing role in healthcare has prompted concerns over privacy and its premature integration. Despite these challenges, AI offers limitless opportunities to improve medication management and treatment regimens, driving advancements across various domains. From improving CT imaging to enhancing adenoma detection in colonoscopies and facilitating medication adherence, AI’s impact on healthcare is profound. Furthermore, AI plays a pivotal role …