Medicine and Health Sciences Commons^™

Comparison Of Ncaa D1 Women’S Basketball Game Day And Previous Practice Training Loads, Kyle Jean, Karissa A. Mesquita, David Clark, Yasuki Sekiguchi

International Journal of Exercise Science: Conference Proceedings

Game day training loads in NCAA Division I Women’s Basketball players differ significantly from practice loads, emphasizing the intense physical demands of competition. Analyzing these variations is crucial for optimizing training strategies, balancing workload, and enhancing recovery. PURPOSE: Examining the game day and the previous week training load before each game in NCAA D1 Women’s Basketball players. METHODS: Eleven females (Age: 22±2years, Height: 183.41±8.92cm, Weight: 84.62±18.78kg) NCAA D1 Women’s Basketball players donned accelerometer units for games and practices from October 2023 through March 2024. Variables collected by the units include Total Distance, Duration, Accumulated Acceleration Load, High Speed …

Effect Of Sodium Glucose Cotransporter 2 Inhibition On Exercise Hyperemia In Older Adults, Harrison A. Peyrovi, Steven A. Romero, Johnathan D. Tune, Ysabella Ruiz-Pick, Asim Kichloo, Gregory M. Dick, Brenda L. Gilliland

International Journal of Exercise Science: Conference Proceedings

Skeletal muscle blood flow is attenuated in older adults performing dynamic exercise which is due, in part, to impaired local vasodilatory mechanisms. Recent preclinical and clinical studies have shown that sodium-glucose cotransporter 2 (SGLT2) inhibitors improve vasodilator function at rest. However, the extent to which this improvement extends to exercise is unknown. PURPOSE: To test the hypothesis that compared with placebo, short-term administration of an SGLT2 inhibitor will increase skeletal muscle blood flow in older adults performing unilateral plantar flexion exercise via increased vascular conductance. METHODS: We utilized a randomized, single-blind, placebo-controlled crossover design. Four older adults (3 women; age …

Co-Existence Of St-Segment Depression And Exaggerated Systolic Blood Pressure Response In Older Runners, Kazumasa Manabe, Owen N. Beck, Justus Ortega, Hirofumi Tanaka

International Journal of Exercise Science: Conference Proceedings

Regular exercise is known to confer substantial benefits for cardiovascular health. However, long-distance runners with abnormal exercise electrocardiography like ST-segment depression have been reported to show a higher prevalence of exercise-induced hypertension, which may link to future cardiovascular events. In recent years, the recommendation to screen and assess cardiovascular risks has extended to various populations including chronically active and seemingly healthy older athletes. PURPOSE: In the retrospective analysis of a previous research study to evaluate walking economy in older adults, we observed a fairly high occurrence of both ST segment depression and peak systolic BP in older endurance-trained athletes. …

Non-Linear Relationship Between Mental Toughness And Anxiety In Ncaa Athletes: Unexpected Mid-Range Vulnerability, Gabriel Rollins, Ernest Rimer, Xavier Smith, Nathan Wells, Brett Hayes, Jennifer Daily, Christopher Peters, Andreas Stamatis

International Journal of Exercise Science: Conference Proceedings

Elite athletes often experience various anxiety symptoms and disorders that, if left untreated, can negatively impact their mental well-being, psychological functioning, and athletic performance. While mental toughness (MT) is generally viewed as advantageous in terms of mental health (MH) outcomes, previous research has suggested that excessively high MT levels may lead to maladaptive behaviors, such as ignoring injuries or delaying help-seeking, which can exacerbate MH challenges. Lately, official organizations (e.g., NCAA) have emphasized the need for structured and regular MH screening (e.g., anxiety) of elite athletes. PURPOSE: To investigate the relationship between MT and anxiety in NCAA student-athletes, specifically …

Vascular Responses During Steady-State Exercise In Adults With Type 1 Diabetes, Ruby A. Nyarko, Ashlesha D. Dalve, Justo Perez Iii, Pratima V. Kumar, Jasdeep Kaur

International Journal of Exercise Science: Conference Proceedings

Type 1 diabetes (T1D) is associated with widespread hyperglycemia-induced vascular damage, which affects both conduit and resistance arteries. This damage has been demonstrated by impaired vasodilatory responses to a 5-minute ischemic stimulus (flow-mediated dilation) and infusion of pharmacological vasodilators in patients with T1D. However, whether this vascular impairment affects blood flow regulation during steady-state exercise in T1D remains unclear. PURPOSE: Herein, we tested the hypothesis that adults with T1D would exhibit blunted forearm blood flow (FBF) and forearm vascular conductance (FVC) during steady-state rhythmic handgrip exercise (RHG), compared to age-matched healthy controls. METHODS: We studied 27 adults (15 …

Examining The Relationship Of E-Cigarette Vapor Exposure And Exercise Performance In Aerobically Trained Rats, Miranda N. Farrar, Nancy Morales

International Journal of Exercise Science: Conference Proceedings

Electronic cigarettes, or e-cigarettes, are alternatives to traditional cigarettes and they are rapidly growing in popularity. These electronic nicotine delivery systems heat up nicotine and vehicle liquids to deliver nicotine to the user via vapor rather than smoke. Although they are touted as a “healthier” alternative to smoking, vape use is associated with changes in heart rate and blood pressure, increased lung inflammation, and reduced mucociliary clearance. Such physiological changes may have an effect on exercise performance and athletic ability. PURPOSE: This study’s purpose was twofold: to train rats to successfully run on a treadmill, and to evaluate the …

Low-Energy Cooling Strategies To Mitigate Thermal Strain Of Older Adults Exposed To Very Hot-Dry Heat, Isa A. Farooqi, Zachary J. Mckenna, Whitley C. Atkins, Elizabeth A. Gideon, Craig G. Crandall

International Journal of Exercise Science: Conference Proceedings

Extreme heat causes morbidity and mortality, particularly among older adults. Although air conditioning can mitigate heat strain, it may be inaccessible due to limited resources, high costs, or power outages. Consequently, cooling strategies other than air-conditioning are needed to mitigate excessive elevations in core temperature and cardiovascular strain in this population. While electric fans offer a low-cost and widely available intervention, their effectiveness in very hot conditions is minimized due to potential increases in heat gain and dehydration. In contrast, skin wetting is a promising low-cost and energy-free cooling strategy that enhances evaporative heat loss. PURPOSE: We tested the hypotheses …

Reliability Of Handgrip Strength Measurements And Their Relationship With Physical Performance Outcomes In Older Women, Alexandra Khartabil, Ty B. Palmer

International Journal of Exercise Science: Conference Proceedings

Handgrip strength measurements, such as peak force and rate of force development (RFD), are effective parameters at characterizing the strength capacities of numerous muscle groups in the upper and lower extremities. Previous studies have determined the reliability of handgrip peak force and RFD in young, college-aged adults. However, the reliability of these measurements in older adults remains unclear. It is also unclear if these measurements are associated with performance during sit-to-stand and medicine ball throw tests. PURPOSE: The primary aim of this study was to examine the reliability of handgrip peak force and RFD measurements in older women. A secondary …

Music Enhances Motor Cortex Excitability In Physically Active Individuals, Anupama Thapa, Ana Carolina Panhan, Erin Lally, Joosung Kim

International Journal of Exercise Science: Conference Proceedings

Music is often used by exercisers and benefits physical performance. The positive effects of music on physical function are induced by the changes in motor cortex excitability while listening to music. Recent studies reveal that modulation of brain excitability in the hand is increased by music but is likely dependent on the characteristics of music tempo, preference, and the individual’s motivational state. No study has explicitly investigated whether music perceived as motivating for exercise creates changes in motor cortex excitability of the quadriceps. PURPOSE: This randomized crossover study examines the effect of the preferred music on motor cortex excitability …

Changes In Gait Patterns: Indicators Of Increased Fall Risk Across Diverse Age Groups, Diego Diaz-Vega, Heontae Kim, Ho Han, Jungyu Lee, Fatima Siddiqua

International Journal of Exercise Science: Conference Proceedings

Gait patterns, including measures such as velocity, step length differential, and various temporal aspects of the gait cycle, are essential indicators of an individual's mobility and balance. With aging, changes in these gait metrics are commonly observed and are closely linked to an increased risk of falls. However, detailed evidence on gait changes across different age groups remains limited, particularly in healthy adults. PURPOSE: The primary aim of this study is to identify key gait metrics and evaluate their potential as indicators of increased fall risk across diverse age groups. METHODS: A total of 252 healthy adults aged …

Accumulated Seasonal Effects Of External Training Load On Performance, Sydnei Mooring, Harsh Buddhadev, Mayrena I. Hernandez, Jennifer Bunn

International Journal of Exercise Science: Conference Proceedings

External training load (ETL), which characterizes the mechanical stress sustained during physical activity, is a key determinant of athletic performance. Understanding seasonal variations in ETL provides valuable insight for optimizing performance and reducing overuse injury risk in volleyball, a sport heavily reliant on vertical jumping actions. PURPOSE: To examine seasonal variations in ETL and performance metrics in high school volleyball athletes, with a specific focus on jump-related mechanical variables. METHODS: This study involved secondary analysis of data collected during a prospective observational study of a 6A high school volleyball team competing in the 2021 Texas University Interscholastic League. Data from …

The Effect Of Menstrual Cycle Phase On Igf-1 And Myostatin After An Acute Bout Of Anaerobic Exercise: A Preliminary Analysis, Kelsi R. Lambright, Cayla Clark, Ashley Latchford, Edwin J. Davila, Dan E. Newmire

International Journal of Exercise Science: Conference Proceedings

Hormonal fluctuations throughout the menstrual cycle influence various physiological processes, including skeletal muscle metabolism. Understanding how anabolic and catabolic pathways respond to anaerobic exercise in females is crucial for uncovering the mechanisms behind muscle adaptations. The limited research on the influence of menstrual cycle fluctuations on muscle metabolism underscores the need for this study and further exploration of exercise physiology in females. PURPOSE: The purpose of this study is to investigate the effects of menstrual cycle phases on the anabolic hormone-insulin-like growth factor-1 (IGF-1) and the catabolic regulator myostatin (GDF-8) in response to a bout of anaerobic exercise in eumenorrheic …

Body Composition Impacts Jump Performance In D1 Athletes, Veronika Kramarenko, Vipa Bernhardt, Michael D. Oldham, Brian Jones, Ouays Bakcha, Chaehyun Byun, Cheyenne Martinez, Joseph Mcclain, Marshall Tousant

International Journal of Exercise Science: Conference Proceedings

INTRODUCTION: Body composition is critical in athletic performance, influencing metrics such as jump height and force production. Variations in body composition, such as increased lean tissue mass and reduced fat mass, have been identified as strong predictors of superior jump performance due to their positive effects on power-to-weight ratios and reduced injury risk (MacDonald et al., 2013). Lean mass is strongly correlated with improved jump performance, as greater lean mass enhances muscle cross-sectional area and, consequently, the force and power generated during physical activities like countermovement jumps (CMJ) (Stephenson et al., 2015). Low body fat percentages are generally associated with …

Developing An Evidence-Based Model For Healthy Stride Length Prediction, Jungyu Lee, Ho Han, Heontae Kim, Diego Diaz-Vega

International Journal of Exercise Science: Conference Proceedings

Stride length is a vital health indicator, reflecting physical fitness and mobility status. Although several existing formulas aim to estimate stride length, many are limited by a lack of scientific validation, especially among healthy, active adults. This study addresses these limitations by developing a validated model based on healthy adults without known mobility impairments, aiming to establish a more accurate, clinically useful standard for stride length estimation. The model provides a reference range for healthy stride length, usable as a tool to identify individuals at risk of mobility issues. PURPOSE: To develop an evidence-based model for predicting stride length …

Pre- To Post-Season Changes In Body Composition And Movement Quality And Quantity In D1 Football Players, Brian Jones, Ouays Bakcha, Chaehyun Byun, Veronika Kramarenko, Cheyenne Martinez, Joseph Mcclain, Marshall Tousant, Vipa Bernhardt, Michael D. Oldham

International Journal of Exercise Science: Conference Proceedings

INTRODUCTION: Body composition may influence an individual's movement efficiency and performance outcomes. Lower body fat percentage may enable individuals, either sedentary or athletic, to perform movements more efficiently, while greater total lean mass may enhance performance in strength and power-related activities. PURPOSE: The purpose of this study was to analyze the changes in collegiate football players’ total lean mass and body fat percentage, as well as movement quantity and quality measures from preseason to postseason. METHODS: Data from a larger study were analyzed for this project. Division 1 male football players (n= 72, 19.6 ± 1.4 yrs) …

The Relationship Between Handgrip Strength And Cardiovascular Risk Factors In Older Women, Adriana N. Guerrero, Emily Sauers

International Journal of Exercise Science: Conference Proceedings

Cardiovascular disease is the leading causes of death in the world. Several clinical trials have found that handgrip strength is associated with lower cardiovascular risk and related death. PURPOSE: The purpose of this study was to explore the relationship between cardiovascular risk factors and handgrip strength. METHODS: Subjects for this study included 8 women from the Congregation of Devine Providence (78.13+7.79 yrs) at Our Lady of the Lake University. Preliminary measures included a medical history questionnaire and the CHAMPS physical activity questionnaire. On the first day of testing, subjects arrived fasted between 7-9am. After a 5-minute rest, blood pressure and …

Does Swearing Improve Exercise Performance And Pain Tolerance?: Cultural Perspective, Jide Yinka Adebiyi, Christos Kyrillou, Elijah Martinez, Anika Patel, Emily Payne, Linsheng Chen, Daroonwan Suksom, Hirofumi Tanaka

International Journal of Exercise Science: Conference Proceedings

Swearing is often generated by self or received from others (e.g., coaches) during physical exertion for various reasons including punctuating the passion, releasing frustration, and resetting the mind. However, the effects of swearing and yelling on exercise performance and pain tolerance remain largely unexplored. Additionally, it is unknown whether individuals from different cultures experience varying degrees of impact of yelling and swearing. PURPOSE: We determined the impact of self-generated and observer-generated swearing and yelling on exercise performance and pain tolerance in individuals living in the US where swearing is often used and heard and in Thailand where such occurrence is …

They’Re Faking It! Diagnosing Mtbis Using A Multimodal Approach, Dakota Muth, Priya Choudhary, Giovani Gourial, Cheryl Vanier, Alan Rodriguez, Travis Snyder

Annual Research Symposium

Purpose: Mild traumatic brain injury (mTBI) affects 69 million people annually worldwide. A significant subset of those affected will develop long-term sequelae that can seriously impact quality of life and lead to other health problems. Clinical diagnosis of mTBI is complicated by patient malingering, subjective symptomatology, and variable patient reporting. This review aimed to evaluate the potential effectiveness of combining advanced neuroimaging techniques with psychometric testing and blood biomarker analyses for developing a more objective and comprehensive mTBI assessment protocol.

Methods: A review was conducted using PubMed as the primary database, analyzing studies published between 2015 and 2023. Included studies …

Building Blocks For New Kinship Partnerships And Coalitions, Kathy L. Dial, Daniel J. Koltz, Janet Salo, Erin Beasley

GrandFamilies: The Contemporary Journal of Research, Practice and Policy

Building successful kinship partnerships and coalitions requires intentional effort to establish trust, align goals, and foster inclusivity. These collaborations are essential for addressing the unique and evolving needs of kinship families, who often face limited access to resources due to the informal nature of many caregiving arrangements. Effective partnerships prioritize clear missions, open communication, and active engagement with stakeholders, particularly those with lived experiences such as kinship caregivers. Research demonstrates that coordinated efforts among organizations enhance resource availability, improve advocacy capabilities, and strengthen service delivery. By integrating diversity, equity, and inclusion principles, coalitions can ensure that diverse perspectives shape solutions …

Polmacoxib: A Drug Review, Sakeer Hussain, Dr. Subramanian Ramaswamy , Professor, Mahabaleshwar Mamadapur Assistant Professor, Ananthu Ajikumar

International Journal of Health and Allied Sciences

Polmacoxib, a novel nonsteroidal anti-inflammatory drug (NSAID), has shown a promised therapeutic option for the management of osteoarthritis and other inflammatory conditions. This drug review mainly aims to provide a comprehensive overview of polmacoxib, focusing on its pharmacological properties, clinical efficacy, safety profile, and potential therapeutic applications. Polmacoxib is a notable drug due to its dual mechanism of action, combining selective COX-2 inhibition with inhibition of carbonic anhydrase, which may contribute to its enhanced anti-inflammatory and analgesic effects. Being a selective COX-2 inhibitor, it helps minimize gastrointestinal side effects typically caused by conventional nonselective NSAIDs. Data from clinical studies suggest …

Assessment Of Chronic Kidney Disease Awareness Among Patients In A Tertiary Care Hospital: A Questionnaire- Based Study, Jyothi Basini, Srija Sadanala, Srinivasa Yadav Poolugari, Susmitha Karakambadi, Teja Apthiri, Ram R

International Journal of Health and Allied Sciences

Chronic kidney disease (CKD) is increasingly recognized as a significant global public health concern, influenced by individuals' lifestyle choices. Despite being largely asymptomatic until advanced stages, CKD is associated with heightened risks of cardiovascular disease, premature mortality, and diminished quality of life. Particularly in developing nations like India, where precise prevalence data are scarce, the need for heightened public awareness is paramount. This study, conducted at SVIMS, Tirupati, employed a hospital-based prospective design involving adults (≥18 years) diagnosed with CKD. Through informed consent, participants underwent interviews using structured questionnaires to assess their understanding of CKD. Multivariate logistic regression analysis identified …

2025 February 18 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Perceptions Of Nurse Preceptor Program Structure, Process, And Outcomes, Shinto Thomas

Walden Dissertations and Doctoral Studies

Precepting is crucial in successfully onboarding nurses in healthcare organizations, yet challenges remain in ensuring effective preceptor development. Well-structured preceptor programs contribute to consistent and safe nursing practices, enhance job satisfaction and competency among new nurses, and improve preceptor effectiveness while minimizing turnover. This quality improvement Doctor of Nursing Practice (DNP) project evaluated a structured nurse preceptor program's structure, process, and outcomes, focusing on its impact on clinical and critical thinking skills development through enhanced training and support. A key gap in understanding the program’s effectiveness was the lack of outcome data. This study explored participants’ perceptions of the preceptor …

Safety And Efficacy Of Different Stent Strategies In Percutaneous Coronary Intervention: A Network Meta-Analysis, Waqas Ullah, Harigopal Sandhyavenu, Syeda Ramsha Zaidi, Mileydis Alonso, Muhammad Atif Khan, Irfan Ullah, Farah Yasmin, Aravind Reddy Polam, Salman Zahid, Arnav Kumar, Ewout Steyerberg, Mohammed Murtaza, Chadi Alraiesm, Jeffrey Rade

Jefferson Health - Northeast Papers (formerly Aria Health Papers)

BACKGROUND: The utility of polymer-permanent, polymer-absorbable, and polymer-free drug-eluting stents (DES) in the context of different eluting drugs in patients undergoing percutaneous coronary intervention (PCI) remains controversial.

OBJECTIVES: The purpose of this study was to compare the efficacy of different DES strategies in post-PCI patients.

METHODS: Digital databases were searched to select all randomized control trials. Different combinations of DES were directly compared with permanent-polymer sirolimus-eluting stents. The primary outcome was major adverse cardiovascular events; a composite of cardiovascular mortality, myocardial infarction (MI), and target vessel revascularization. A network meta-analysis was performed to determine the net relative risk (RR) and …

Deep5mc: Predicting 5-Methylcytosine (5mc) Methylation Status Using A Deep Learning Transformer Approach, Evan Kinnear, Houssemeddine Derbel, Zhongming Zhao, Qian Liu

Faculty, Staff and Student Publications

DNA methylations, such as 5-methylcytosine (5mC), are crucial in biological processes, and aberrant methylations are strongly linked to various human diseases. Genomic 5mC is not randomly distributed but exhibits a strong association with genomic sequences. Thus, various computational methods were developed to predict 5mC status based on DNA sequences. These methods generated promising achievements and overcome the limitations of experimental approaches. However, few studies have comprehensively investigated the dependency of 5mC on genomic sequences, and most existing methods focus on specific genomic regions. In this work, we introduce Deep5mC, a deep learning transformer-based method designed to predict 5mC methylations. Deep5mC …

Paradigm Shift In Obesity Treatment: An Extensive Review Of Current Pipeline Agents, Ecesu Çeti̇n, Brian Pedersen, Mehmet Furkan Burak

Turkish Journal of Medical Sciences

Obesity is a multifaceted disease that poses a significant public health challenge. Recent discoveries in understanding the biological pathways that regulate satiety and metabolism have led to a shift in the treatment paradigm for obesity. Thus, the gap between pharmacological and surgical interventions has diminished. The latest approved anti-obesity medications are achieving weight loss comparable to surgery. These GLP-1 analog-based therapies not only cause substantial weight loss but also improve obesity-associated comorbidities. However, there are still unmet needs in obesity care, and treatment options with alternative pathways are necessary. Whether achieved through lifestyle changes or medication, weight loss often leads …

Navigating Pregnancy With Cardiovascular Disease: Pathophysiology, Risk Stratification, And Maternal–Fetal Outcomes, Osman Türkmen, Serra Akar İnan

Turkish Journal of Medical Sciences

Pregnancy induces significant cardiovascular changes, including increases in heart rate, blood volume, and cardiac output, which may exacerbate existing heart conditions or unmask previously undiagnosed heart diseases.. This review outlines the types of cardiovascular diseases that affect pregnant women, organized by the modified World Health Organization risk classification. It covers key areas, including how pregnancy impacts the heart, common maternal and fetal complications, and effective management strategies. The review emphasizes the importance of preconception counseling, risk assessment, and continuous monitoring to ensure the best maternal and fetal outcomes. It also highlights practical guidelines for healthcare providers and discusses the latest …

Antifungal Prophylaxis In High-Risk Patients With Hematologic Malignancy:A Comparison Of Practice With Guidelines In Türkiye, Özlem Güzel Tunçcan, Seçki̇n Çağirgan, Hakan Özdoğu, Si̇nem Ci̇vri̇z Bozdağ, Fi̇li̇z Vural, Mustafa Pehli̇van, Hüseyi̇n Saffet Beköz, Yasemi̇n Esen, Tuba Koç, Petek Gi̇li̇k, Esi̇n Şenol

Turkish Journal of Medical Sciences

Background/aim: Primary antifungal prophylaxis (AFP) is recommended by guidelines as the gold standard for patients with hematologic malignancies. This study aimed to investigate the level of knowledge and translation of guideline recommendations into real-life setting among physicians in Türkiye.Materials and methods: In this prospective, observational study, the physicians’ knowledge of ΑFP guideline recommendations in patients with acute myeloid leukaemia (AML) or myelodysplastic syndrome (MDS) undergoing first remission-induction (Group I), and graft-versus-host-disease (GvHD) after allogeneic stem cell transplant (Group II), was compared with clinical practice via 11-item multiple-choice questionnaire evaluating the timing and patients in whom AFP was initiated, with AFP …

Thoracic Disc Herniations: Diagnosis, Surgical Techniques, And Complication Insights, Mehmet Deni̇zhan Yurtluk, Aydin Si̇nan Apaydin, Hakan Kina, Khoi Than

Turkish Journal of Medical Sciences

Abstract: Thoracic disc herniations (TDHs) are rare conditions, comprising 0.1% to 5% of all reported herniation cases, and affecting up to 1 in 1,000,000 individuals. The mid to lower thoracic spine, particularly between the T11 and T12 vertebrae, is most frequently affected and often associated with trauma. Conditions like Scheuermann’s disease can predispose patients to TDHs. This study explores the clinical manifestations, diagnostic methods, surgical techniques, and complications associated with TDHs. Diagnosis relies on magnetic resonance imaging and computed tomography myelography to identify the level and nature of the herniation. Various surgical approaches, including posterolateral, lateral, and anterior, have been …

Synthetic Osteobiologics In Spine Surgery: A Review, Aydin Si̇nan Apaydin, Eli Johnson, Prince Antwi, Brett Rocos, Michael M. Haglund, Christopher Shaffrey, Peter Passias, Muhammad Adb-El-Barr, Khoi Than

Turkish Journal of Medical Sciences

Background/aimOsteobiologics are increasingly used in orthopedics and spine surgery to facilitate bone healing and prevent non-union. Synthetic osteobiologics are artificial materials crafted in laboratories that aim to replicate the natural composition and functionality of bone. Notable examples, such as calcium phosphate and calcium sulfate, are engineered to mirror the mineral aspect of bone. They mimic human bone functionality, exhibiting osteoconductive, osteoinductive, and osteogenic properties. These characteristics promote cell attachment, migration, recruitment, and differentiation. Consequently, synthetic osteobiologics (osteoconductive grafts) have been introduced in bone fracture repair. The main strength of synthetic osteobiologics in spine surgery lies in improving fusion rates and …