Medicine and Health Sciences Commons^™

Demographic And Clinical Characterization Of Bone Metastases And Primary Malignant Bone Neoplasia In The Rio Grande Valley, Blake C. Martin, Neharika Penmetcha, Aun Bangash, Juan Lopez Alvarenga

Research Symposium

Background: The Rio Grande Valley (RGV) is a developing clinical research region characterized by its distinctive demographic profile that offers an opportunity to investigate diverse health issues. This pilot investigation seeks to identify the characteristics of patients diagnosed with bone metastasis and primary malignant bone neoplasia (PMBN) in the RGV. The main objective was to evaluate the demographic and clinical characteristics linked to bone metastases and PMBN in patients from the Rio Grande Valley. We hypothesized that older age and higher BMI individuals would have greater frequency of metastatic lesions compared to PMBN.

Methods: Data was gathered from the …

Demographic And Clinical Characteristics Of Patients With Benign Bone Tumors: Evidence Of Bimodal Age Distribution In A Hispanic Population, Blake C. Martin, Mohammad Khalil, Juan Lopez Alvarenga

Research Symposium

Background: As far as researchers know, there’s no way to prevent BBTs from forming. Although these tumors generally do not metastasize, they can still be dangerous as they may grow and compress healthy tissues and lead to poor outcomes. The principal objective was to evaluate the demographic and clinical characteristics linked to BBTs in individuals from the Rio Grande Valley. We hypothesized that older age, males, and higher BMI individuals would have greater frequency of BBTs.

Methods: This was a retrospective chart review and IRB approval was obtained prior to starting this study. We obtained medical charts for individuals who …

Comprehensive Management Of A High-Risk Pregnant Woman With A Meningoendothelial Meningioma: A Case Report, Blake C. Martin, Kevin Garcia Valdez, Anesu Karen Murambadoro, Tirath Patel, Bharathi S. Gadad, Kelsey Baker

Research Symposium

Background: Meningiomas are the most common CNS tumors and are associated with complications including localized neurological impairments, seizures, and reduced quality of life. These tumors have an incidence twice as high in women as in men, increasing with age and peaking in the seventh and eighth decades of life. The main risk factor for developing meningiomas is exposure to ionizing radiation, although research suggests hormones also contribute. The higher incidence in women, presence of hormone receptors in some tumors, and changes during pregnancy, the menstrual cycle, and menopause, suggest a hormonal link. While pregnancy does not increase meningioma incidence, symptoms …

Characterizing Fracture Distribution By Sex, Age, And Body Region: Insights From A Regional Population Study, Blake C. Martin, Jared Hensley, Juan Lopez Alvarenga

Research Symposium

Background: This Rio Grande Valley (RGV) region of South Texas is a unique region that is impoverished and medically underserved. We conducted this study in order to further the knowledge of orthopedics in this unique, medically underserved community. We sought to determine if certain body regions, based on sex and age, were at increased risk for fracture in this population. We hypothesized that females would have increased fracture frequency at older ages while males would have increased fracture frequency at all other ages. We also hypothesized that femur and forearm fractures would be increased in females compared to males.

Methods …

Bone And Joint Infections: A Retrospective Chart Review Of The Medically Underserved Rio Grande Valley, Blake C. Martin, Chloe Harris, Manoj Peiris

Research Symposium

Background: The Rio Grande Valley (RGV) is a demographically unique region that is impoverished and medically underserved. Because of its unique patient population, this community may be at increased risk for bone and joint infections and the morbidity and mortality that follows. The goal of this study was to analyze individuals with osteomyelitis, septic arthritis, and periprosthetic joint infections and determine which infectious bone or joint conditions are most prevalent in the Rio Grande Valley and determine if there were any demographic disparities between the various types of bone and joint infections and healthy individuals. We hypothesized that age and …

National Cancer Centers And Cancer Rates In Nevada, 2017-2021, Yashesvi Sharma, Ivan Sun, Taylor Volk, Caitlin J. Saladino, William E. Brown Jr., Fatma Nasoz

Health

This fact sheet presents data from the National Institutes of Health including the National Cancer Institute’s (NCI) “State Cancer Profiles” report and includes age-adjusted cancer incidence rates by race/ethnicity in Nevada, between 2017 and 2021. The fact sheet also shows data from the 2024 National Cancer Institute’s “NCI-Designated Cancer Centers” map, listing NCI-Designated Cancer Centers by state, and the distance to the nearest NCI-Designated Cancer Centers from the Las Vegas metro and Reno metro.

Impact Of Pausinystalia Johimbe On Cytochrome P450: A Potential Risk For Polypharmacy, Pankul Kotwal, Islam Husain, Olivia R. Dale, Suresh Chandra V. A. R. Annam, Amar G. Chittiboyina, Ikhlas A. Khan, Shabana I. Khan

Annual Poster Session 2024-2025

Pausinystalia johimbe, a tree native to West Africa, contains yohimbine as its primary active compound which was traditionally used as an aphrodisiac, has gained attention for its diverse pharmacological effects such as weight loss promotion, athletic performance enhancement, mood improvement, potential anxiety reduction and cognitive function enhancement. Recent studies have revealed that the primary mechanism of action of yohimbine is as an α2-adrenergic receptor antagonist, affecting fat metabolism, vasodilation, and sympathetic nervous system activity. PXR and AhR are xenobiotic receptors that regulate the expression of drugmetabolizing Cytochrome P450 enzymes (CYPs) and transporters like Pglycoprotien (P-gp). Concomitant consumption of phytochemicals …

The Association Between Socioeconomic Status And Appropriate Antibiotic Use Among Women With Uncomplicated Urinary Tract Infection, Nga-Weng (Ivy) Leong, Shishir Maharjan, Yi Yang

Annual Poster Session 2024-2025

Women with low socioeconomic status (SES) were more likely to develop urinary tract infections. Inappropriate antibiotic use can lead to treatment failure and future multidrugresistant infections. However, the relationship between SES and inappropriate treatment has yet to be established.

The study aims to assess the relationship between SES and guidelines-concordance antibiotic use among women with uncomplicated urinary tract infection (uUTI).

The Athletes’ Plate: Understanding Influences Of Athletes’ Eating Attitudes, Exercise Behaviors, And Body Image Satisfaction, Delanie Patterson, Brooklynn Raacke, Ryssa Schlaefli

SACAD: Scholarly Activities

Delanie Patterson¹, Brooklynn Raacke¹, and Ryssa Schlaefli²

¹Department of Psychology, Fort Hays State University

²Department of Health and Human Performance, Fort Hays State University

Faculty Sponsors: Brooke Mann¹, Ph.D. and Jessica Phelan², Ph.D.

¹Department of Psychology, Fort Hays State University

²Department of Health and Human Performance, Fort Hays State University

Hays, Kansas

Introduction: Disordered eating (DE), compulsive exercise (CE), and body image satisfaction (BIS) negatively affect male and female athletes. These variables each have a core symptomology but continue to evolve with the increased usage of social …

Use Of A Taqman Array Card For Identification Of Enterotoxins And Colonization Factors Directly From Stool Samples In An Enterotoxigenic E Coli Vaccine Study, Jie Liu, T Sakari Jokiranta, Nils Carlin, Suzanne Stroup, Jixian Zhang, Bjorn Sjostrand, Ann-Mari Svennerholm, Eric R Houpt, Anu Kantele

Faculty and Staff Publications

Enterotoxigenic Escherichia coli (ETEC) is a leading cause of childhood and travelers' diarrhea. The vaccine candidate ETVAX encompasses several ETEC colonization factors (CFs) with a hybrid LT (heat-labile toxin)/cholera toxin B subunit adjuvanted with a double-mutant LT. Stool samples from a Phase 2b ETVAX trial were tested by a PCR-based customized TaqMan Array Card (TAC), including three ETEC toxin genes (LT and heat-stable toxins, STh and STp) and 18 ETEC CFs. Stool samples were also tested with the molecular platform Amplidiag and culture, followed by GM1-enzyme-linked immunosorbent assay (ELISA) and inhibition GM1-ELISA for LT and ST and dot blot for …

Investing In Residential Real Estate: Understanding Homebuilder Exchange-Traded Fund Performance, Robert W. Mcleod, Davinder K. Malhotra

School of Business Faculty Papers

Homebuilder ETFs provide investors with a diversified portfolio of residential construction and sales companies which reduces risks associated with individual stock selection in the sector. This study examines the net monthly returns of homebuilder exchange-traded funds (ETFs) through various performance evaluation models and market situations. The results reveal that these ETFs outperformed benchmark indices in absolute returns. Despite homebuilding being part of the real estate sector, the correlation between monthly returns of homebuilder ETFs and the Dow Jones US Real Estate Index, though positive, is not very high. The performance of ETFs varied across market conditions, demonstrating both outperformance and …

Developing And Implementing Pediatric Nephrology Milestones 2.0 As An Efficient Tool For Trainee Evaluation And Just-In-Time Feedback., Caroline V. Jackson, Rebecca Hjorten, Laura Edgar, Beatrice Goilav, Roshan P. George, Darcy K. Weidemann

Manuscripts, Articles, Book Chapters and Other Papers

In 2013, the Accreditation Council for Graduate Medical Education (ACGME) implemented Milestones 1.0 as a tool to assess trainee progress towards readiness for independent practice. Critiques of Milestones 1.0 suggested its complexity made the tool difficult to quickly understand and implement in a standardized fashion. This was particularly challenging among subspecialties due to inherent differences in clinical practice settings and make-up of procedural and patient care needs. In response, ACGME launched Milestones 2.0 in 2016 to harmonize competencies applicable to all subspecialties and develop new subspecialty specific competencies to facilitate precise feedback on subspecialty specific content domains. We describe how …

Cultivating A Trauma-Informed Lens Into Outpatient Supportive Oncology Via The Interdisciplinary Team, Ramona Sitko, Msw, Lcsw

Kimmel Cancer Center Papers, Presentations, and Grand Rounds

Background
A cancer diagnosis often brings with it a profound sense of existential threat. For individuals with a history of trauma, it can activate a trauma response, manifesting as anxiety, depression, difficulty processing information, and challenges in adhering to a medical treatment plan. Health care providers in oncology settings should strive to recognize these responses to more effectively address patient concerns and help minimize potential barriers to care. Trauma Informed Care (TIC) is a framework developed by SAMHSA (Substance Abuse and Mental Health Services Administration) which can help providers realize, recognize, respond, and resist retraumatization of patients.

Objectives
Examine the …

Resolution Of Pain At Night And Improved Functional Outcomes After Arthroscopic Partial Meniscectomy, Evan T. Zheng, Koya Osada, Jillian L. Mazzocca, Natalie A. Lowenstein, Jamie E. Collins, Elizabeth G. Matzkin

SKMC Student Presentations and Publications

BACKGROUND: Arthroscopic partial meniscectomy (APM) is performed for symptomatic meniscal tears that fail conservative treatment. Patients often report pain at night, although little research has been done to evaluate corresponding outcomes.

PURPOSE: To (1) evaluate patients with and without preoperative nighttime pain who underwent APM and (2) assess postoperative resolution of symptoms and associated patient-reported outcome measures (PROMs).

STUDY DESIGN: Case series; Level of evidence, 4.

METHODS: Consecutive patients undergoing primary APM with or without chondroplasty at a tertiary academic center were prospectively enrolled in a database. Patient characteristics and PROMs were obtained pre- and postoperatively up to 2 years-including …

Heterogeneity Of Layer 1 Interneurons In The Mouse Medial Prefrontal Cortex, Chen Shen, Wanpeng Cui, Wen Cheng Xiong, Lin Mei

Faculty Scholarship

Cortical Layer 1 (L1) acts as a critical relay for processing long-range inputs. GABAergic inhibitory interneurons (INs) in this layer (Layer 1 interneurons [L1INs]) function as inhibitory gates, regulating these inputs and modulating the activity of deeper cortical layers. However, their characteristics and circuits in the medial prefrontal cortex (mPFC) remain poorly understood. Using biocytin labeling, we identified three distinct morphological types of mPFC L1INs: neurogliaform cells (NGCs), elongated NGCs (eNGCs), and single-bouquet cell-like (SBC-like) cells. Whole-cell recordings revealed distinct firing patterns across these subtypes: NGCs and eNGCs predominantly exhibited late-spiking (LS) patterns, and SBC-like cells displayed a higher prevalence …

Neighborhood Disinvestment And Racial And Ethnic Disparities In Peripartum Cardiomyopathy In California, From 2004 To 2019, Curisa M. Tucker Phd, Rn, Chen Ma, Mahasin S. Mujahid, Afshan B. Hameed, Audrey Lyndon, Elliott K. Main, Suzan L. Carmichael

Publications

BACKGROUND: Peripartum cardiomyopathy (PPCM) is a rare medical condition presenting as idiopathic heart failure. The aim of this study was to (1) examine the contribution of neighborhood disinvestment to PPCM risk and to racial and ethnic disparities in PPCM; (2) examine the extent to which sociodemographic factors and chronic hypertension explain these outcomes; and (3) describe severe maternal morbidity cases and the timing of PPCM. METHODS: We conducted an observational cohort study using vital records longitudinally linked with hospital discharge records for mothers and infants up to 9 months postpartum for births in California from 1997 to 2019. Using the …

5-Hydroxymethylcytosine Sequencing Of Plasma Cell-Free Dna Identifies Epigenomic Features In Prostate Cancer Patients Receiving Androgen Deprivation Therapies, Qianxia Li, Chiang-Ching Huang, Shane Huang, Yijun Tian, Jinyong Huang, Amirreza Bitaraf, Xiaowei Dong, Marja T. Nevalainen, Manishkumar Patel, Jodie Wong, Jingsong Zhang, Brandon J Manley, Jong Y. Park, Manish Kohli, Elizabeth M. Gore, Deepak Kilari, Liang Wang

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

BACKGROUND: We evaluated whether 5hmC signatures in cell-free DNA (cfDNA) are associated with treatment failure to androgen-deprivation therapies (ADT) among men with hormone-naive prostate cancer.

METHODS: We collected a total of 139 serial plasma samples from 55 prostate cancer patients receiving ADT at 3 time points including baseline (before initiating ADT, n = 55); 3 months (after initiating ADT, n = 55); and disease progression (n = 15) within 24 months or 24 months if no progression was detected (n = 14). We used selective chemical labeling sequencing to quantify 5hmC abundance across the genome and Kaplan-Meier analysis to assess …

The Cost-Effectiveness Of Long-Term Post-Treatment Peer Recovery Support Services In The United States, Sierra Castedo De Martell, Margaret Brannon Moore, Hannah Wang, Lori Holleran Steiker, J Michael Wilkerson, Nalini Ranjit, Sheryl A Mccurdy, H Shelton Brown

Faculty, Staff and Student Publications

Background:

Peer recovery support services (PRSS) have been widely adopted across a variety of settings, but little is known about their economic impact.

Objectives:

To conduct a cost-effectiveness analysis of long-term, PRSS delivered after specialty substance use disorder (SUD) treatment (post-treatment), and to describe the development of a free, web-based cost-effectiveness calculator based on this analysis.

Methods:

Using publicly-available data from a variety of sources, post-treatment PRSS were compared to specialty SUD treatment from the societal (broad perspective including costs like participant time) and health systems perspectives (only costs borne by health system), and in terms of quality-adjusted life years …

Privacy-Preserving Framework For Genomic Computations Via Multi-Key Homomorphic Encryption, Mina Namazi, Mohammadali Farahpoor, Erman Ayday, Fernando Pérez-González

Faculty, Staff and Student Publications

Motivation: The affordability of genome sequencing and the widespread availability of genomic data have opened up new medical possibilities. Nevertheless, they also raise significant concerns regarding privacy due to the sensitive information they encompass. These privacy implications act as barriers to medical research and data availability. Researchers have proposed privacy-preserving techniques to address this, with cryptography-based methods showing the most promise. However, existing cryptography-based designs lack (i) interoperability, (ii) scalability, (iii) a high degree of privacy (i.e. compromise one to have the other), or (iv) multiparty analyses support (as most existing schemes process genomic information of each party individually). Overcoming …

Learning Directed Acyclic Graphs For Ligands And Receptors Based On Spatially Resolved Transcriptomic Data Of Ovarian Cancer, Shrabanti Chowdhury, Sammy Ferri-Borgogno, Peng Yang, Wenyi Wang, Jie Peng, Samuel C Mok, Pei Wang

Faculty, Staff and Student Publications

To unravel the mechanism of immune activation and suppression within tumors, a critical step is to identify transcriptional signals governing cell-cell communication between tumor and immune/stromal cells in the tumor microenvironment. Central to this communication are interactions between secreted ligands and cell-surface receptors, creating a highly connected signaling network among cells. Recent advancements in in situ-omics profiling, particularly spatial transcriptomic (ST) technology, provide unique opportunities to directly characterize ligand-receptor signaling networks that power cell-cell communication. In this paper, we propose a novel statistical method, LRnetST, to characterize the ligand-receptor interaction networks between adjacent tumor and immune/stroma cells based on ST …

Scupa: Single-Cell Unified Polarization Assessment Of Immune Cells Using The Single-Cell Foundation Model, Wendao Liu, Zhongming Zhao

Faculty, Staff and Student Publications

MOTIVATION: Immune cells undergo cytokine-driven polarization in response to diverse stimuli, altering their transcriptional profiles and functional states. This dynamic process is central to immune responses in health and diseases, yet a systematic approach to assess cytokine-driven polarization in single-cell RNA sequencing data has been lacking.

RESULTS: To address this gap, we developed single-cell unified polarization assessment (Scupa), the first computational method for comprehensive immune cell polarization assessment. Scupa leverages data from the Immune Dictionary, which characterizes cytokine-driven polarization states across 14 immune cell types. By integrating cell embeddings from the single-cell foundation model Universal Cell Embeddings, Scupa effectively identifies …

Fusionpub, A Therapeutic Landscape Of Human Fusion Genes, Himansu Kumar, Abayomi Adegunlehin, Zikang Chen, Pora Kim

Faculty, Staff and Student Publications

To advance the development of fusion protein-targeting therapeutics, it is crucial to understand how patients with fusion oncoproteins have been treated and what small molecules have been studied. To fill this gap, we developed FusionPub, a knowledgebase of the therapeutic landscape of human fusion genes. We searched PubMed abstracts for 107K human fusion genes with 14K drugs. We also searched PubMed abstracts for 18K human fusion proteins, considering all gene synonyms of individual partner genes with 14K drugs. After manual curation, we found 17 342 records from 9623 PubMed abstracts. For these fusion genes and drugs, we provide a summary …

Periumbilical Perforating Pseudoxanthoma Elasticum, Ana L. Duarte-Summers, Anna Chen, Morgan E. Sussman-Mccrea, Shayan Waseh, Jason B. Lee, Sylvia Hsu

Department of Dermatology and Cutaneous Biology Faculty Papers

No abstract provided.

Addressing Health Disparities In Hematologic Malignancies: From Genes To Outreach, Christopher R Flowers, Rachel W Anantha, Veronica Leautaud, Pinkal Desai, Chancellor E Donald, Michelle A T Hildebrandt, Jean L Koff, Rulla M Tamimi, Wendy Cozen, Chijioke Nze, Ari M Melnick

Faculty, Staff and Student Publications

This review underscores our shared responsibility to champion multidimensional strategies rooted in basic and translational science, community involvement, and societal responsiveness for a meaningful impact. Unifying themes include the need to enhance collaborative infrastructure to engage laboratory researchers, epidemiologists, data scientists, clinicians, patients, community leaders, and policymakers; patient-level support services; outreach, education, and navigation for patients at the community level; recruitment and retention of underrepresented groups in the healthcare and research workforce; and funding for these efforts.

The Hepatocellular Model Of Fatty Liver Disease: From Current Imaging Diagnostics To Innovative Proteomics Technologies, Renee Hernandez, Natasha Garcia-Rodriguez, Marco A. Arriaga, Ricardo Perez, Auwal A. Bala, Ana C. Leandro, Vincent P. Diego, Marcio A. Almeida, Jason Parsons, Eron G. Manusov, Jacob Galan

School of Medicine Publications

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is a prevalent chronic liver condition characterized by lipid accumulation and inflammation, often progressing to severe liver damage. We aim to review the pathophysiology, diagnostics, and clinical care of MASLD, and review highlights of advances in proteomic technologies. Recent advances in proteomics technologies have improved the identification of novel biomarkers and therapeutic targets, offering insight into the molecular mechanisms underlying MASLD progression. We focus on the application of mass spectrometry-based proteomics including single cell proteomics, proteogenomics, extracellular vesicle (EV-omics), and exposomics for biomarker discovery, emphasizing the potential of blood-based panels for noninvasive diagnosis and …

Proteomics Of Extracellular Vesicles: Recent Updates, Challenges And Limitations, Mohini Singh, Prashant Kumar Tiwari, Vivek Kumar Kashyap, Sanjay Kumar

School of Medicine Publications

Extracellular vesicles (EVs) are lipid-bound vesicles secreted by cells, including exosomes, microvesicles, and apoptotic bodies. Proteomic analyses of EVs, particularly in relation to cancer, reveal specific biomarkers crucial for diagnosis and therapy. However, isolation techniques such as ultracentrifugation, size-exclusion chromatography, and ultrafiltration face challenges regarding purity, contamination, and yield. Contamination from other proteins complicates downstream processing, leading to difficulties in identifying biomarkers and interpreting results. Future research will focus on refining EV characterization for diagnostic and therapeutic applications, improving proteomics tools for greater accuracy, and exploring the use of EVs in drug delivery and regenerative medicine. In this review, we …

Crisis Communication About The Maui Wildfires On Tiktok: Content Analysis Of Engagement With Maui Wildfire-Related Posts Over 1 Year, Jim P Stimpson, Aditi Srivastava, Ketan Tamirisa, Joseph KeaweʻAimoku Kaholokula, Alexander N Ortega

2020-Current year OA Pubs

BACKGROUND: The August 2023 wildfire in the town of Lāhainā on the island of Maui in Hawai'i caused catastrophic damage, affecting thousands of residents, and killing 102 people. Social media platforms, particularly TikTok, have become essential tools for crisis communication during disasters, providing real-time crisis updates, mobilizing relief efforts, and addressing misinformation. Understanding how disaster-related content is disseminated and engaged with on these platforms can inform strategies for improving emergency communication and community resilience.

OBJECTIVE: Guided by Social-Mediated Crisis Communication theory, this study examined TikTok posts related to the Maui wildfires to assess content themes, public engagement, and the effectiveness …

Non-Invasive Assessment Of Vascular Damage Through Pulse Wave Velocity And Superb Microvascular Imaging In Pre-Dialysis Patients, Julia Martín-Vírgala, Beatriz Martín-Carro, Sara Fernández-Villabrille, Belinda Fernández-Mariño, Elena Astudillo-Cortés, Minerva Rodríguez-García, Carmen Díaz-Corte, José Luis Fernández-Martín, Carlos Gómez-Alonso, Adriana S Dusso, Cristina Alonso-Montes, Manuel Naves-Díaz, Sara Panizo, Natalia Carrillo-López

2020-Current year OA Pubs

No abstract provided.

Association Of Joint Disease With Demographic Factors In Clinical Populations Of The Rio Grande Valley, Blake C. Martin, Devian D. Baez, Juan C. Lopez-Alvarenga

Research Symposium

Background: The Rio Grande Valley (RGV) is a medically underserved, demographically unique population that warrants the exploration of various conditions, including joint conditions, such as osteoarthritis (OA), rheumatoid arthritis (RA), gout, ankylosing spondylitis (AS), psoriatic arthritis (PA), juvenile idiopathic arthritis (JIA), and septic arthritis (SA). We sought to determine the demographic disparities between the different types of common joint conditions in this community. We hypothesized that OA would follow national trends and be the most common joint condition in the Rio Grande Valley. We hypothesized that the demographics between the various joint conditions would vary depending on age, sex, BMI, …

Using Network Pharmacology To Systematically Deduce The Molecular Mechanism Of The Selective Perinucleolar Compartment Inhibitor Ml246, Bhuvnesh P. Sharma, Himanshu N. Singh, Bhupesh Singh, Deepak Parashar, Kuldeep K. Roy, Murali M. Yallapu, Subhash C. Chauhan, Vivek K. Kashyap

Research Symposium

Metarrestin (ML246) is an orally bioavailable synthetic molecule that selectively disrupts the perinucleolar compartment (PNC) structure, and it has showed promise in preclinical studies for metastatic cancer therapy. However, the precise molecular mechanism of ML246 remains poorly understood. We investigated the topological and protein interaction network (PIN) analyses of ML246 to determine the molecular mechanism of ML246. To determine the regulatory effect of ML246 on the rewired PIN of ML246, an intercom was constructed using 25 oncogenic key proteins. These proteins were selected using the reverse pharmacophore matching approach (based on a fit score > 0.502) using the STRING database and …