Medicine and Health Sciences Commons^™

Assessing And Addressing Distress For Informal Caregivers Caring For Oncology Patients, Megan Murphy, Carrie Ann Matyac (Project Chair)

Providence Nursing Research Conference 2023 – Present

No abstract provided.

Between A Badge Buddy And Policy: An Ebqi Tool For Critical Care Nurses, Sean Robinson

Providence Nursing Research Conference 2023 – Present

No abstract provided.

From Pressure To Prevention: Elevating Care With Air-Assisted Repositioning In The Icu, Julia Wyrick, Jillian Nichols, Caitlin Silva

Providence Nursing Research Conference 2023 – Present

No abstract provided.

I Like To Move It: Nurse Driven Protocol For Early Mobility In Icu Patients, Jenna Drazovich, Patrick Cink

Providence Nursing Research Conference 2023 – Present

No abstract provided.

Evaluating Use And Outcomes Of An Infusion Pump-Ehr Interface System, Julia Robins

Providence Nursing Research Conference 2023 – Present

Purposes/Aims: The purpose of this program evaluation is to assess the effectiveness of an infusion pump-EHR interface system, Alaris Interoperability, on the incidence of medication errors, consistency of staff utilization, accuracy of documentation, staff satisfaction and clinical outcomes in an inland northwest intensive care unit (ICU).

Rationale/Background: Medication errors are preventable events that account for nearly half of all medical injuries, with an annual global estimated cost of $42 billion USD (WHO, 2023; WHO, n.d.).

In spring 2023, a 197-bed community hospital implemented Alaris Interoperability, a program intended to standardize intravenous medication administration. This program created a virtual interface between …

Effects Of Clinical Nursing Protocol On Intravenous Piggyback Infusion (Ivpb) Practice, Kayla Smith, Sheila Doucette, Theresa Miller, Danni Sloane, Barbara (Basia) Delawska-Elliott, Michael P Simanonok

Providence Nursing Research Conference 2023 – Present

Title:

Effects of a Clinical Nursing Protocol on Intravenous Piggyback Infusion Practice

Purpose:

The purpose of our study was to review whether the introduction of a nursing protocol policy impacted adherence to best practice in utilizing secondary tubing as an Intravenous Piggyback (IVPB) set up for the administration of IV antibiotics in a 483-bed tertiary urban facility.

Background:

Without a nursing protocol policy in place, nurses did not have a standardized method for administering IVPB antibiotics prior to March 2023. Practice variability could lead to violation of the medication rights, RNs practicing outside of their scope, and cause potential patient …

You, Me, And Clinical Inquiry: An Ecg Program Evaluation, Naomi A. Leland, Jessica Mclain, Leanna Ross

Providence Nursing Research Conference 2023 – Present

No abstract provided.

Evaluating The Impact Of A Unit-Based Mentorship Program On Nurses' Intent To Stay And Retention, Koratney Speidel

Providence Nursing Research Conference 2023 – Present

No abstract provided.

Implementing And Sustaining Change In A Complex Healthcare System, Renee Rassilyer-Bomers, Diem Pham, Adam Corson

Providence Nursing Research Conference 2023 – Present

No abstract provided.

Workplace Violence Prevention Strategies For Nurses In The Acute Setting, Kelly Galbo

Providence Nursing Research Conference 2023 – Present

No abstract provided.

Skin-To-Skin Care To Decrease Length Of Stay For Late Preterm Newborns, Theresa Bowden, Colleen Applegate, Susan Stauffer, Alex Schmidt, Lisa Mcgill-Vargas, Barbara Bennett-Wolcott

Providence Nursing Research Conference 2023 – Present

No abstract provided.

Timing Of Neurologic Pupil Index Assessments In Comatose Patients Undergoing Target Temperature Management After Out-Of-Hospital Cardiac Arrest, Jill Carington, Cherie Fox, Teresa Wavra, Michael P Simanonok

Providence Nursing Research Conference 2023 – Present

No abstract provided.

I Spy Quality And Safety, Shauna Szyszkowski, Rachel Bauer

Providence Nursing Research Conference 2023 – Present

No abstract provided.

Bridging The Gap: A New Approach To Retaining Icu Nurses In Their First Year, Megan Jones, Kristen Mayberry, Sarah Sumner

Providence Nursing Research Conference 2023 – Present

No abstract provided.

Guardians Of The Catheters, Interprofessional Collaboration Reduced Cauti Rates At Phfh, Dawn Doud, Angie Shemwell, Stephanie Brown, Tobi Bryan, Georgia Gauron, Tasha Anisimov, Peter Weitzman, Emma Peterson, Tiffanie Rampley

Providence Nursing Research Conference 2023 – Present

No abstract provided.

Heterogeneity Of Rna-Binding Protein Dnd1 In G0 Male Germ Cells May Provide A Selection Process For Spermatogonial Stem Cell Development, Kayla Friedman, Talia Hatkevich, Blanche Capel

Osmosis Magazine

The ability to reproduce is dependent upon proper development of the germline. In male Mus musculus, germline development involves male germ cells (MGCs) differentiating into spermatogonial stem cells (SSCs), the precursors for male gametes. During this differentiation period, MGCs enter a quiescent phase (G0), an essential stage for SSC development. This G0 phase accompanies changes in transcription as well as chromatin accessibility and re-methylation of DNA.

Research Summary, Abigail Mcentire, Dr. Michael Norris

Osmosis Magazine

Carbon dioxide emitted from combustion has been shown to be the primary cause of climate change, leading to many environmental issues both current and predicted for the future.

The Triassic Cuddle: A Tale Of Love And Extinction, Jack Dupuy

Osmosis Magazine

An injured amphibian crawls into a burrow to escape from harsh reality. Outside, the shrieks of dying animals pierce the silence over a hellish backdrop of flowing lava and dark, ominous clouds of volcanic ash. Still recovering from broken ribs and trying its best to survive the desolate conditions, the amphibian curls up next to the burrow's owner, a mammal-like reptile. Moments later, a flash flood traps and drowns the unlikely roommates, immortalizing their relationship for the next 250 million years.

Using Machines To Guide Your Online Shopping Decisions, Daniel Verdi Do Amarante

Osmosis Magazine

I bet you’ve heard the term artificial intelligence in various conversations by now. But do you understand the process of teaching machines to develop abilities that are comparable – sometimes even better – to those of humans? At the University of Richmond, Dr. Park’s lab does just that.

An Ever-Growing Web: Spider Silk In Medicine, Andrew Watts

Osmosis Magazine

For decades, graduates from the University of Richmond have crafted a robust web of alumni spanning various regions and professions. Much like its graduates, Richmond’s famed spider mascot has been capitalizing on the strength of its own web and engineering solutions to the most pressing problems in a new and rather unexpected territory–medicine.

Spider silk has unique chemical and physical properties that allow it to be used in many different capacities.

Re-Captcha, Isabel Dilandro

Osmosis Magazine

They tried to warn us of what would come, but we didn’t listen. Why should we? For years the world had told us that we were smarter than everything else. Better. More advanced. The very science of biology existed to remind us that we were the superior race. We were untouchable. Until now. If only we hadn’t ignored the warning signs. Perhaps we could have stopped the madness before it began. Unfortunately, we neglected to put a leash on the dog because we assumed it wouldn’t bite.

Letter From The Editor, Lily Dickson

Osmosis Magazine

Dear Reader,

Welcome to this semester's issue of Osmosis! We are a student-run magazine filled with all things science. This year, this includes scientific articles, research abstracts, and even science fiction stories, all written by fellow UR students. We have a talented group of writers, editors, and designers this year, and I cannot wait to share with you our fall issue. Whatever made you open up our magazine today, whether it be the cover art or the allure of science, I hope you find something you enjoy as much as we enjoyed putting it all together.

Thanks to all who …

Osmosis Magazine - Fall 2022

Osmosis Magazine

Osmosis is a student read, led, and written publication from the University of Richmond, focusing on all aspects of healthcare and science.

Ormeloxifene-Mediated Attenuation Of Β-Catenin Signaling In Hepatocellular Carcinoma Progression, Mohammed Sikander, Shabnam Malik, Daniel Zubieta, Anyssa Rodriguez, Molly Vela, Sheema Khan, Fathi T. Halaweish, Murali M. Yallapu, Meena Jaggi, Subhash C. Chauhan

Research Symposium

Background: Hepatocellular carcinoma (HCC) is the most prevalent form of primary liver cancer, with approximately 41,000 new cases and 29,000 deaths annually in the U.S. The management of HCC poses significant challenges due to severe toxicity and inadequate responses to existing chemotherapeutic agents. Aberrant β-catenin signaling is recognized as a crucial factor influencing the differentiation grades of HCC patients. Therefore, there is an urgent need to identify more effective and non-toxic β-catenin inhibitors for cancer treatment. Notably, ormeloxifene (ORM), a clinically approved selective estrogen receptor modulator with a favorable therapeutic index, has demonstrated remarkable anticancer activity, making it a promising …

Novel Analogue Of Ormeloxifene Suppresses Epithelial-Mesenchymal Transition By Disrupting Β-Catenin Signaling In Cervical Cancer, Mohammed Sikander, Shabnam Malik, Sonam Kumari, Sheema Khan, John Apraku, Aditya Ganju, Parvez Khan, Fathi T. Halaweish, Murali Yallapu, Meena Jaggi, Subhash Chauhan

Research Symposium

Background: Cervical cancer (CxC) is a leading cause of mortality and morbidity among women worldwide. Current chemotherapeutic agents for CxC have shown systemic toxicity in CxC patients. Ormeloxifene (ORM) is a non-toxic and non-steroidal drug with well-defined pharmacokinetic and pharmacodynamic properties in humans. Studies have shown its anticancer potential in various pre-clinical mouse models. Here, we have synthesized and characterized a novel analogue of ormeloxifene, Bromo-ormeloxifene (Br-ORM), which showed more therapeutic efficacy against CxC in vitro and in vivo model systems.

Methodology: The effect of Br-ORM on CxC cells (CaSki and SiHa) growth and proliferation was determined by colony formation …

Proteomic Profiling Of Stress-Associated Proteins In Hepatocellular Carcinoma And The Hepatoprotective Effects Of Silymarin, Mohammad Shabir Hussain, Yamile A. Anaya, Amairani Sanchez, Sophia Leslie, Manish Kumar Tripathi

Research Symposium

Background: The liver is the principal organ responsible for the detoxification of exogenous and endogenous toxins, xenobiotics, and viruses and bacteria, making it susceptible to damage by various chemicals and metabolites that enter the body. In clinical relevance, Hepatocellular carcinoma (HCC) is a major global health concern, being the sixth most common cancer worldwide and third leading cause of cancer-related death. HCC accounts for 85–90% of liver cancers globally. Texas is projected to have the second-highest liver cancer-related deaths, with Hispanic populations experiencing the highest mortality rates. The liver, a vital metabolic organ, is particularly vulnerable to stress-induced damage. According …

Geographic And Ethnic Disparities In Melanoma Diagnosis Age: A Comparative Study Of The Rio Grande Valley And Other Texas Counties, Natasha N. Quailes, Smaran Marupudi, Elias Arellano Villanueva, Olivia Samaie, Angel Phillip, Jared Hensley, Maria Villegas, Bharathi Gadad

Research Symposium

Background: Melanoma, a serious skin cancer, has varied demographic, geographic, and genetic influences on diagnosis and survival. Understanding the factors contributing to age at diagnosis and survival disparities can guide public health strategies and interventions. This study examines data from the Texas Cancer Registry to assess the age of melanoma diagnosis and associated differences between individuals in the Rio Grande Valley (RGV) and other counties in Texas, focusing on Hispanic and Non-Hispanic populations.

Methodology: Using data from the Texas Cancer Registry (TCR) spanning 1995-2019, this analysis included patients categorized into two geographic groups: the RGV (Hidalgo, Cameron, Starr, and Willacy …

The Effect Of Artificial Intelligence On High Tibial Osteotomies, Mohammad Khalil, David Rakay, Mohammad Y. Karkoutly, Zayd Ayas, Omar Karkoutly

Research Symposium

Background: High tibial osteotomy (HTO) is a surgical procedure which helps in managing lower limb deformities, provides pain relief, and arrests the progression of osteoarthritis of the knee joint. This surgical method involves cutting and realignment of the tibia and this is only as effective as the accuracy with which the tibia is cut and realigned and this success is based on the understanding of the biomechanics and the anatomical characteristics of the patient. Artificial Intelligence (AI) is becoming more widespread in the field of orthopaedic surgery, with applications in diagnostics, pre-operative planning, and predictive models of outcomes following procedures. …

Return To Sport After Anterior Shoulder Stabilization Of Ncaa Football And Nfl Athletes – A Systematic Review, Yolanda V. Gutierrez, Mohammad Khalil, Aasim Ahmad, Aamir Ahmad

Research Symposium

Background: Anterior shoulder instability is an injury prevalent in contact and non-contact athletes and can result in limited movement, increased recurrence of dislocation, and decreased quality of sports activity. Notable sports that present with frequent anterior shoulder instability include wrestling, hockey, basketball, baseball, and most commonly, football. Athletes may undergo surgical management of anterior shoulder instability via arthroscopic repair, remplissage, Laterjet, or glenoid bone grafting procedures. This review aims to evaluate the return-to-sport rates among elite football athletes in the NCAA and NFL following surgical stabilization, assess post-surgical performance, and analyze the recurrence of instability or complications.

Methods: This systematic …

Incidence Of Diabetes And Obesity In Adhesive Capsulitis Cases In The Rio Grande Valley, Mohammad Khalil, Blake Martin

Research Symposium

Background: Adhesive capsulitis, or frozen shoulder, is a condition characterized by pain and restricted motion in the shoulder joint. Previous studies implicate diabetes as one of the core risk factors for the condition, along with thyroid disease, female sex, and prolonged immobilization. This study aims to investigate the incidence of diabetes and obesity in patients diagnosed with adhesive capsulitis in the Rio Grande Valley, a region with a high prevalence of metabolic disorders.

Methods: A retrospective analysis (IRB-24-0306) was conducted on 836 patients diagnosed with adhesive capsulitis. Demographic variables, including age, sex, and ethnicity, were collected. Clinical data regarding shoulder …