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Articles 16411 - 16440 of 24659
Full-Text Articles in Medicine and Health Sciences
Physical Activity, Smokeless Tobacco, Urban/Rural Status And E-Cigarette Use Among African American Young Adults, Destiny Britt
Physical Activity, Smokeless Tobacco, Urban/Rural Status And E-Cigarette Use Among African American Young Adults, Destiny Britt
Walden Dissertations and Doctoral Studies
The growing prevalence of e-cigarette use is fueled by the false belief that they are safer than traditional cigarettes. African American adults aged 18 and older are disproportionately impacted by tobacco products, including e-cigarettes. Little research focuses specifically on e-cigarette use among young African Americans, examining how factors like physical activity, smokeless tobacco, and urban/rural status influence their usage. This study aimed to investigate these influences while considering gender, academic level, alcohol and marijuana use, cigarette smoking, and anxiety/depression as controlling factors. Using the social ecological model (SEM), the research sought to understand how environmental factors interact with individual behaviors, …
Preimplantation Genetic Testing And Disorders Of Placental Implantation: A Systematic Review And Meta-Analysis, Isaac J Chamani, Lauren L Taylor, Hailie Ciomperlik, Timothy Dunn, Anna C Reynolds, Beatriz Varman, Karin A Fox, Laura Detti
Preimplantation Genetic Testing And Disorders Of Placental Implantation: A Systematic Review And Meta-Analysis, Isaac J Chamani, Lauren L Taylor, Hailie Ciomperlik, Timothy Dunn, Anna C Reynolds, Beatriz Varman, Karin A Fox, Laura Detti
Library Staff Publications
PURPOSE: To evaluate whether embryo biopsy for preimplantation genetic testing (PGT) during in vitro fertilization (IVF) increases the risk of disorders related to abnormal placental implantation.
METHODS: A systematic search of Medline, Embase, and Web of Science was performed on February 17, 2023, and identified studies on placental implantation anomalies following PGT in IVF patients. The primary outcome was placenta accreta spectrum (PAS), while secondary outcomes included placental abruption, placenta previa, preterm premature rupture of membranes (PPROM), and hypertensive pregnancy disorders. Only peer-reviewed randomized controlled trials, cohort, case-control, and cross-sectional studies in English were considered. Two reviewers independently screened citations, …
Fall Prevention In An Acute Inpatient Crisis Stabilization Unit, Kerenge Ayuk Ako-Ebot
Fall Prevention In An Acute Inpatient Crisis Stabilization Unit, Kerenge Ayuk Ako-Ebot
Walden Dissertations and Doctoral Studies
Summary The type of project was a staff education designed to increase staff knowledge through the implementation of an evidence-based fall prevention program tailored to an acute inpatient crisis stabilization unit. The practice problem was a lack of standardization in fall prevention. The project question was the following: Does staff education on fall prevention measures increase staff knowledge in an acute crisis stabilization unit? A total of 22 health care professionals, including registered nurses, certified nursing assistants, mental health technicians, and physical and occupational therapists, participated in the educational presentation. Pretest and posttest data showed a significant improvement in staff …
Are Mildly Disabled Patients Appropriate For Spine Bundles? An Application Of The Operative Value Index, Advith Sarikonda, Ashmal Sami, D. Mitchell Self, Emily Isch, Alexander Zavitsanos, Antony A. Fuleihan, Ayra Khan, Conor Dougherty, Danyal A. Quraishi, Jack Jallo, Joshua Heller, Srinivas K. Prasad, Ashwini Sharan, James Harrop, Alex R. Vaccaro, Ahilan Sivaganesan
Are Mildly Disabled Patients Appropriate For Spine Bundles? An Application Of The Operative Value Index, Advith Sarikonda, Ashmal Sami, D. Mitchell Self, Emily Isch, Alexander Zavitsanos, Antony A. Fuleihan, Ayra Khan, Conor Dougherty, Danyal A. Quraishi, Jack Jallo, Joshua Heller, Srinivas K. Prasad, Ashwini Sharan, James Harrop, Alex R. Vaccaro, Ahilan Sivaganesan
Department of Neurosurgery Faculty Papers
BACKGROUND: Many studies have evaluated the effect of preoperative disability status on functional outcomes following spine surgery. However, no research has compared the "value" (outcomes per dollar spent) of surgery for patients with different levels of diagnosis-specific disability.
METHODS: We retrospectively reviewed 429 patients who underwent neurosurgical anterior cervical discectomy and fusion. Time-driven activity-based costing was used to calculate total intraoperative costs. Neck Disability Index (NDI) scores were recorded at baseline and 3 months postsurgery. Patients were categorized into groups based on their preoperative NDI score. Our primary outcome was a novel Operative Value Index (OVI), defined as the percent …
Alcohol Use Disorder Medication Coverage And Utilization Management In Medicaid Managed Care Plans, Maureen T. Stewart, Sage R. Feltus, Christina Andrews Ph.D., Andrea Acevedo, Cindy Parks Thomas, Jeffrey Bratberg, Constance M. Horgan, Dominic Hodgkin, Rachel Sayko Adams
Alcohol Use Disorder Medication Coverage And Utilization Management In Medicaid Managed Care Plans, Maureen T. Stewart, Sage R. Feltus, Christina Andrews Ph.D., Andrea Acevedo, Cindy Parks Thomas, Jeffrey Bratberg, Constance M. Horgan, Dominic Hodgkin, Rachel Sayko Adams
Faculty Publications
IMPORTANCE Evidence-based, patient-centered treatment for alcohol use disorder (AUD) can include pharmacotherapy with naltrexone, acamprosate, or disulfiram; however, these medications are rarely used. Medicaid managed care plans (MCPs) manage health services for nearly 80% of Medicaid enrollees and are the largest payer for addiction treatment services. Little is known about Medicaid MCP policies for AUD medications.
OBJECTIVES To describe Medicaid MCPs’ coverage and management of acamprosate, naltrexone, and disulfiram for AUD and examine associations of plan characteristics and state policies with medication coverage.
DESIGN, SETTING, AND PARTICIPANTS In this cross-sectional study, a content analysis was performed of 2021 insurance benefit …
Female Patients Report Comparable Results To Males After The Implantation Of An Aragonite-Based Scaffold For The Treatment Of Knee Chondral And Osteochondral Defects: A Gender-Based Analysis Of A Rct At 4 Years' Follow-Up., Elizaveta Kon, Francesca De Caro, Vinod Dasa, Jason M Scopp, Berardo Di Matteo, David Flanigan, Nogah Shabshin, Sabrina Strickland, Nir Altschuler
Female Patients Report Comparable Results To Males After The Implantation Of An Aragonite-Based Scaffold For The Treatment Of Knee Chondral And Osteochondral Defects: A Gender-Based Analysis Of A Rct At 4 Years' Follow-Up., Elizaveta Kon, Francesca De Caro, Vinod Dasa, Jason M Scopp, Berardo Di Matteo, David Flanigan, Nogah Shabshin, Sabrina Strickland, Nir Altschuler
School of Medicine Faculty Publications
No abstract provided.
Protocol And Design Of The Repose Study: A Double-Blinded, Randomised, Placebo-Controlled Trial To Evaluate The Efficacy Of Suvorexant To Improve Postoperative Sleep And Reduce Delirium Severity In Older Patients Undergoing Non-Cardiac Surgery, John Michael Fallon, Mona Hashemaghaie, Christy E. Peterson, Dieplinh Tran, Sophie R. Wu, Jonathan M. Valdes, Nicole M. Pedicini, Melissa E. Adams, Marjorie Soltis, Wissam Mansour, Mary Cooter Wright, Karthik Raghunathan, Miriam M. Treggiari, Cina Sasannejad, Michael J. Devinney
Protocol And Design Of The Repose Study: A Double-Blinded, Randomised, Placebo-Controlled Trial To Evaluate The Efficacy Of Suvorexant To Improve Postoperative Sleep And Reduce Delirium Severity In Older Patients Undergoing Non-Cardiac Surgery, John Michael Fallon, Mona Hashemaghaie, Christy E. Peterson, Dieplinh Tran, Sophie R. Wu, Jonathan M. Valdes, Nicole M. Pedicini, Melissa E. Adams, Marjorie Soltis, Wissam Mansour, Mary Cooter Wright, Karthik Raghunathan, Miriam M. Treggiari, Cina Sasannejad, Michael J. Devinney
School of Medicine Faculty Publications
INTRODUCTION: Postoperative delirium occurs in up to 40% of older surgical patients and has been associated with prolonged hospital stays, long-term cognitive impairment and increased 1-year postoperative mortality. Postoperative sleep disturbances may increase the risk of delirium, but studies investigating pharmacotherapies to improve postoperative sleep to prevent delirium remain limited. Suvorexant is a selective antagonist of orexin 1 and 2 receptors and is approved for insomnia pharmacotherapy by the Food and Drug Administration. It has the potential to improve postoperative sleep and reduce postoperative delirium rates, but randomised controlled trials (RCTs) are needed to determine the efficacy of postoperative suvorexant …
Developing A Novel Index For Individual-Level Social Determinants And Cardiovascular Diseases In The Coronary Artery Risk Development In Young Adults (Cardia) Study, Tao Gao, Yinan Zheng, Brian Joyce, Lei Liu, Lili Liu, Catarina Kiefe, Sarah Forrester, Bing Yu, Ankeet Bhatt, Penny Gordon-Larsen, Donald Lloyd-Jones, Kai Zhang, Lifang Hou
Developing A Novel Index For Individual-Level Social Determinants And Cardiovascular Diseases In The Coronary Artery Risk Development In Young Adults (Cardia) Study, Tao Gao, Yinan Zheng, Brian Joyce, Lei Liu, Lili Liu, Catarina Kiefe, Sarah Forrester, Bing Yu, Ankeet Bhatt, Penny Gordon-Larsen, Donald Lloyd-Jones, Kai Zhang, Lifang Hou
Faculty, Staff and Student Publications
Background: Social determinants of health (SDH) have been found to contribute to cardiovascular risk and the development of cardiovascular disease (CVD). However, few studies have examined early-life exposure to SDH and the combined effect of multiple SDH measures on CVD. There is an urgent need to develop an SDH index for use in practice and clinical settings.
Methods: A total of 3189 participants from the CARDIA Study who had chest CT scans at the year-25 (Y25) visit were included in this study. Personal and parental SDH measures, including education, occupation, income, financial strain, and childhood family environment, were obtained through …
Second-Site Periprosthetic Joint Infection After Subsequent Primary Hip Or Knee Arthroplasty: Risk Factor Assessment, Daniel Aris Nikolaidis, Devin Young, Robert Runner, Mark S. Karadsheh, Andrew Steffensmeier
Second-Site Periprosthetic Joint Infection After Subsequent Primary Hip Or Knee Arthroplasty: Risk Factor Assessment, Daniel Aris Nikolaidis, Devin Young, Robert Runner, Mark S. Karadsheh, Andrew Steffensmeier
Conference Presentation Abstracts
INTRODUCTION: The risk factors for developing a periprosthetic joint infection (PJI) are well described. However, those associated with developing a second-site or metachronous PJI (MPJI) following a subsequent primary arthroplasty are poorly understood. The purpose of our study is to determine (1) prevalence and (2) risk factors associated with developing a second-site PJI in patients with a prior history of PJI who undergo a subsequent THA or TKA. METHODS: A retrospective, single-center case-control study identified 77 patients treated for an index PJI (hip or knee) between 2013-2022, and who also underwent another primary arthroplasty after completing treatment for their first …
Efficacy And Safety Of Venetoclax Plus Azacitidine For Patients With Treatment-Naive High-Risk Myelodysplastic Syndromes, Jacqueline S Garcia, Uwe Platzbecker, Olatoyosi Odenike, Shaun Fleming, Chun Yew Fong, Uma Borate, Meagan A Jacoby, Daniel Nowak, Maria R Baer, Pierre Peterlin, Brenda Chyla, Huipei Wang, Grace Ku, David Hoffman, Jalaja Potluri, Guillermo Garcia-Manero
Efficacy And Safety Of Venetoclax Plus Azacitidine For Patients With Treatment-Naive High-Risk Myelodysplastic Syndromes, Jacqueline S Garcia, Uwe Platzbecker, Olatoyosi Odenike, Shaun Fleming, Chun Yew Fong, Uma Borate, Meagan A Jacoby, Daniel Nowak, Maria R Baer, Pierre Peterlin, Brenda Chyla, Huipei Wang, Grace Ku, David Hoffman, Jalaja Potluri, Guillermo Garcia-Manero
Faculty, Staff and Student Publications
Outcomes are poor in patients with higher-risk myelodysplastic syndromes (HR MDS) and frontline treatment options are limited. This phase 1b study investigated safety and efficacy of venetoclax, a selective B-cell lymphoma 2 inhibitor, at the recommended phase 2 dose (RP2D; 400 mg for 14 days per 28-day cycle), in combination with azacitidine (75 mg/m2 for 7 days per 28-day cycle) for treatment-naive HR MDS. Safety was the primary outcome, and complete remission (CR) rate was the primary efficacy outcome. Secondary outcomes included rates of modified overall response (mOR), hematologic improvement (HI), overall survival (OS), and time to next treatment (TTNT). …
Deep Learning Models Based On Pretreatment Mri And Clinicopathological Data To Predict Responses To Neoadjuvant Systemic Therapy In Triple-Negative Breast Cancer, Zhan Xu, Zijian Zhou, Jong Bum Son, Haonan Feng, Beatriz E Adrada, Tanya W Moseley, Rosalind P Candelaria, Mary S Guirguis, Miral M Patel, Gary J Whitman, Jessica W T Leung, Huong T C Le-Petross, Rania M Mohamed, Bikash Panthi, Deanna L Lane, Huiqin Chen, Peng Wei, Debu Tripathy, Jennifer K Litton, Vicente Valero, Lei Huo, Kelly K Hunt, Anil Korkut, Alastair Thompson, Wei Yang, Clinton Yam, Gaiane M Rauch, Jingfei Ma
Deep Learning Models Based On Pretreatment Mri And Clinicopathological Data To Predict Responses To Neoadjuvant Systemic Therapy In Triple-Negative Breast Cancer, Zhan Xu, Zijian Zhou, Jong Bum Son, Haonan Feng, Beatriz E Adrada, Tanya W Moseley, Rosalind P Candelaria, Mary S Guirguis, Miral M Patel, Gary J Whitman, Jessica W T Leung, Huong T C Le-Petross, Rania M Mohamed, Bikash Panthi, Deanna L Lane, Huiqin Chen, Peng Wei, Debu Tripathy, Jennifer K Litton, Vicente Valero, Lei Huo, Kelly K Hunt, Anil Korkut, Alastair Thompson, Wei Yang, Clinton Yam, Gaiane M Rauch, Jingfei Ma
Faculty, Staff and Student Publications
Purpose: To develop deep learning models for predicting the pathologic complete response (pCR) to neoadjuvant systemic therapy (NAST) in patients with triple-negative breast cancer (TNBC) based on pretreatment multiparametric breast MRI and clinicopathological data.
Methods: The prospective institutional review board-approved study [NCT02276443] included 282 patients with stage I-III TNBC who had multiparametric breast MRI at baseline and underwent NAST and surgery during 2016-2021. Dynamic contrast-enhanced MRI (DCE), diffusion-weighted imaging (DWI), and clinicopathological data were used for the model development and internal testing. Data from the I-SPY 2 trial (2010-2016) were used for external testing. Four variables with a …
Efficacy And Safety Of Venetoclax Plus Azacitidine For Patients With Treatment-Naive High-Risk Myelodysplastic Syndromes, Jacqueline S Garcia, Uwe Platzbecker, Olatoyosi Odenike, Shaun Fleming, Chun Yew Fong, Uma Borate, Meagan A Jacoby, Daniel Nowak, Maria R Baer, Pierre Peterlin, Brenda Chyla, Huipei Wang, Grace Ku, David Hoffman, Jalaja Potluri, Guillermo Garcia-Manero
Efficacy And Safety Of Venetoclax Plus Azacitidine For Patients With Treatment-Naive High-Risk Myelodysplastic Syndromes, Jacqueline S Garcia, Uwe Platzbecker, Olatoyosi Odenike, Shaun Fleming, Chun Yew Fong, Uma Borate, Meagan A Jacoby, Daniel Nowak, Maria R Baer, Pierre Peterlin, Brenda Chyla, Huipei Wang, Grace Ku, David Hoffman, Jalaja Potluri, Guillermo Garcia-Manero
Faculty, Staff and Student Publications
Outcomes are poor in patients with higher-risk myelodysplastic syndromes (HR MDS) and frontline treatment options are limited. This phase 1b study investigated safety and efficacy of venetoclax, a selective B-cell lymphoma 2 inhibitor, at the recommended phase 2 dose (RP2D; 400 mg for 14 days per 28-day cycle), in combination with azacitidine (75 mg/m2 for 7 days per 28-day cycle) for treatment-naive HR MDS. Safety was the primary outcome, and complete remission (CR) rate was the primary efficacy outcome. Secondary outcomes included rates of modified overall response (mOR), hematologic improvement (HI), overall survival (OS), and time to next treatment (TTNT). …
Cranial Radiation Disrupts Dopaminergic Signaling And Connectivity In The Mammalian Brain, Die Zhang, Riya Thomas, Thanh Thai Lam, Ines Veselinovic, David R Grosshans
Cranial Radiation Disrupts Dopaminergic Signaling And Connectivity In The Mammalian Brain, Die Zhang, Riya Thomas, Thanh Thai Lam, Ines Veselinovic, David R Grosshans
Faculty, Staff and Student Publications
Cognitive impairment is a common and challenging side effect of cranial radiation therapy for brain tumors, though its precise mechanisms remain unclear. The mesocortical dopaminergic pathway, known to play a key role in cognitive function, is implicated in several neuropsychiatric disorders, yet its involvement in radiation-induced cognitive dysfunction is unexplored. Here, with using in vivo multi-electrode array recordings of both anesthetized and free-moving rats to monitor the firing activities of dopamine neurons in the ventral tegmental area (VTA) and local field potentials in both the prefrontal cortex (PFC) and VTA, as well as the immunofluorescence assays and western blotting, we …
Increasing Patient Age And General Anesthesia Are Risk Factors For Failure Of Same-Day Discharge Total Hip Arthroplasty, Kevin Xavier Farley, Robert Dean, Mark S. Karadsheh, Drew Douglas Moore
Increasing Patient Age And General Anesthesia Are Risk Factors For Failure Of Same-Day Discharge Total Hip Arthroplasty, Kevin Xavier Farley, Robert Dean, Mark S. Karadsheh, Drew Douglas Moore
Conference Presentation Abstracts
INTRODUCTION: As cost containment efforts in orthopedic surgery increase, there has been a rise in same-day discharge total hip arthroplasty (THA). Same-day discharge THA has been further accelerated by the COVID-19 pandemic and the removal of THA from the Medicare inpatient only list. This study sought to evaluate risk factors for readmission following same-day discharge THA. METHODS: From 2012-2021, the National Surgical Quality Improvement Project database was used to identify all patients undergoing elective THA discharged the day of surgery to their home. Demographic, comorbid, and operative variables were collected, as displayed in Table 1. Readmission within 30-days of surgery …
Developing A Novel Index For Individual-Level Social Determinants And Cardiovascular Diseases In The Coronary Artery Risk Development In Young Adults (Cardia) Study, Tao Gao, Yinan Zheng, Brian Joyce, Lei Liu, Lili Liu, Catarina Kiefe, Sarah Forrester, Bing Yu, Ankeet Bhatt, Penny Gordon-Larsen, Donald Lloyd-Jones, Kai Zhang, Lifang Hou
Developing A Novel Index For Individual-Level Social Determinants And Cardiovascular Diseases In The Coronary Artery Risk Development In Young Adults (Cardia) Study, Tao Gao, Yinan Zheng, Brian Joyce, Lei Liu, Lili Liu, Catarina Kiefe, Sarah Forrester, Bing Yu, Ankeet Bhatt, Penny Gordon-Larsen, Donald Lloyd-Jones, Kai Zhang, Lifang Hou
2020-Current year OA Pubs
BACKGROUND: Social determinants of health (SDH) have been found to contribute to cardiovascular risk and the development of cardiovascular disease (CVD). However, few studies have examined early-life exposure to SDH and the combined effect of multiple SDH measures on CVD. There is an urgent need to develop an SDH index for use in practice and clinical settings.
METHODS: A total of 3189 participants from the CARDIA Study who had chest CT scans at the year-25 (Y25) visit were included in this study. Personal and parental SDH measures, including education, occupation, income, financial strain, and childhood family environment, were obtained through …
Functional Characterization Of Cryopreserved Plasmodium Yoelii Sporozoites In Vitro, Victoria I. Mills
Functional Characterization Of Cryopreserved Plasmodium Yoelii Sporozoites In Vitro, Victoria I. Mills
USF Tampa Graduate Theses and Dissertations
Malaria is a major global health burden, contributing to morbidity and mortality across various continents. Due to challenges in malaria research and its advancements, developing novel interventions and further understanding host-parasite interactions is required for future studies. Plasmodium vivax is a human malaria species that is difficult to maintain in laboratory settings, posing obstacles in research. Cryopreservation offers a reliable method to provide a consistent supply of sporozoites for reproducible studies. Plasmodium yoelii is a rodent malaria model commonly used in studies due to its genetic similarity to human malaria species. Utilizing cryopreserved P. yoelii sporozoites potentially extends their usability …
A Scoping Review Of Sleep Disturbances In Children And Adolescents With Abdominal Pain Disorders., Hunter J. Friesen, Neha Singh, Jennifer Verrill Schurman, Amanda D. Deacy, Craig A. Friesen, Jennifer Colombo
A Scoping Review Of Sleep Disturbances In Children And Adolescents With Abdominal Pain Disorders., Hunter J. Friesen, Neha Singh, Jennifer Verrill Schurman, Amanda D. Deacy, Craig A. Friesen, Jennifer Colombo
Manuscripts, Articles, Book Chapters and Other Papers
OBJECTIVE/PURPOSE/AIM: Sleep disturbances have been implicated as contributors to chronic pain. We undertook this review to assess the current literature regarding sleep disturbances in youth with chronic abdominal pain. We assessed studies evaluating prevalence, pathophysiology, and/or outcomes to identify gaps in knowledge and to determine whether there is an evidential basis for sleep interventions in this population.
MATERIALS AND METHODS: Utilizing Google Scholar, Pub Med, SCOPUS, and Embase, we searched using the terms "sleep disturbances" AND ("abdominal pain"/exp OR "abdominal pain") AND ([adolescent]/lim OR [school]/lim). Articles were included if they contained data regarding sleep disturbance prevalence, pathophysiology, or relationships to …
Understanding Hereditary Breast And Ovarian Cancer Syndrome In Black/African American Women: Implications For Equitable Outcomes And Interventions, Alexandria E. Fletcher
Understanding Hereditary Breast And Ovarian Cancer Syndrome In Black/African American Women: Implications For Equitable Outcomes And Interventions, Alexandria E. Fletcher
Walden Dissertations and Doctoral Studies
Black/African American women face significant health disparities in hereditary breast and ovarian cancer syndrome (HBOC) due to systemic barriers to genetic counseling and testing, leading to poorer survival outcomes. Guided by the Social Determinants of Health (SDH) framework and Intersectionality Theory, this quantitative descriptive study examined disparities in access to genetic services, socioeconomic barriers, and healthcare biases. Data from the 2023 National Health Interview Survey (NHIS) included 1,357 Black/African American and White women aged 25–65 with a family history of HBOC. The Surveillance, Epidemiology, and End Results (SEER) dataset analyzed 15,684 Black/African American and 105,547 White women with breast cancer, …
Structure-Guided Design Of Partial Agonists At An Opioid Receptor, Balazs R Varga, Sarah M Bernhard, Amal El Daibani, Jhoan Aguilar, Kevin Appourchaux, Alexa Kouvelis, Amynah Pradhan, Susruta Majumdar, Tao Che, Et Al.
Structure-Guided Design Of Partial Agonists At An Opioid Receptor, Balazs R Varga, Sarah M Bernhard, Amal El Daibani, Jhoan Aguilar, Kevin Appourchaux, Alexa Kouvelis, Amynah Pradhan, Susruta Majumdar, Tao Che, Et Al.
2020-Current year OA Pubs
Chronic pain and opioid overdose deaths highlight the need for non-addictive analgesics with novel mechanisms. The δ opioid receptor (δOR) is a promising target, as it lacks the respiratory depression associated with µ opioid receptor (µOR) agonists. However, early δOR full agonists caused seizures, limiting their clinical use. Partial δOR agonists may offer more controlled receptor activation than full agonists, but their development has been hindered by uncertainty regarding the molecular mechanism of partial agonism. Here we show that C6-Quino, a bitopic ligand developed through structure-based design, acts as a selective δOR partial agonist. Functional studies reveal that C6-Quino shows …
Antibodies To Recombinant Human Alpha-L-Iduronidase Prevent Disease Correction In Cortical Bone In Mps I Mice, Sarah C Hurt, Steven Q Le, Shih-Hsin Kan, Quang D Bui, Michael D Brodt, Patricia I Dickson
Antibodies To Recombinant Human Alpha-L-Iduronidase Prevent Disease Correction In Cortical Bone In Mps I Mice, Sarah C Hurt, Steven Q Le, Shih-Hsin Kan, Quang D Bui, Michael D Brodt, Patricia I Dickson
2020-Current year OA Pubs
Mucopolysaccharidosis I (MPS I) is a lysosomal storage disorder caused by deficiency of the enzyme α-l-iduronidase (IDUA). Failure of enzyme replacement therapy (ERT) to treat skeletal disease may be due to development of anti-IDUA antibodies, found previously to alter tissue distribution of ERT in animal models. To test this hypothesis, immunocompromised (non-obese diabetic [NOD]-severe combined immunodeficiency [SCID]) MPS I mice were treated with weekly ERT from birth (ERT alone). Some mice also received weekly injections of rabbit immunoglobulin G (IgG) against IDUA (immunized rabbit immune globulin [IRIG]) concomitant with ERT, imitating antibodies developed in patients (ERT+IRIG). Mice treated with ERT+IRIG …
Differences In Plasma Metabolome Between Non-Hispanic White And Non-Hispanic Black Women, Ghazaleh Pourali, Liang Li, Myung Sik Jeon, Jingqin Luo, Chongliang Luo, Adetunji T Toriola
Differences In Plasma Metabolome Between Non-Hispanic White And Non-Hispanic Black Women, Ghazaleh Pourali, Liang Li, Myung Sik Jeon, Jingqin Luo, Chongliang Luo, Adetunji T Toriola
2020-Current year OA Pubs
BACKGROUND: To understand potential racial differences in disease susceptibility and develop targeted prevention strategies, it is essential to establish biological differences between racial groups in healthy individuals. However, knowledge about how race impacts metabolites is limited. We therefore performed a cross-sectional study using comprehensive metabolomics analysis to investigate racial differences in metabolites among 506 non-Hispanic White (NHW) women and 163 non-Hispanic Black (NHB) women.
METHODS: We performed untargeted plasma metabolomic profiling using Metabolon's platform (Durham, NC®) and identified 1074 metabolites in 9 super-pathways. We used multivariable linear regression models, adjusted for confounders, to identify associations between race and metabolites. We …
Development Of A Personal Health Recommendation System Based On Data And Machine Learning To Improve User Wellbeing, Eliyah Acantha Manapa Sampetoding, Andi Alisha Faiqihah, Yulita Sirinti Pongtambing
Development Of A Personal Health Recommendation System Based On Data And Machine Learning To Improve User Wellbeing, Eliyah Acantha Manapa Sampetoding, Andi Alisha Faiqihah, Yulita Sirinti Pongtambing
Jurnal Administrasi Bisnis Terapan
The development of personal health recommendation systems has become a significant focus of research, along with the increasing need to improve user well-being. This research critically examines options in data and data mining and Machine Learning to support the establishment of systems to recommend better and improved healthcare services. Drawing on the results of a systematic review of past literature, the study shows that the application of Machine Learning algorithms in disease opinion learning, health condition classification, and demographics is emerging as a prospect for driving clinical decisions. Various models, from Deep Learning to traditional machine learning models such as …
Influence Of Marching Band Experience On Eating Disorder Risk And Perceived Stress In Collegiate Marching Artists, Kalor Greve, Jaclyn B. Caccese, Matthew P. Brancaleone
Influence Of Marching Band Experience On Eating Disorder Risk And Perceived Stress In Collegiate Marching Artists, Kalor Greve, Jaclyn B. Caccese, Matthew P. Brancaleone
Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association
Introduction: Collegiate marching artists face severe and prevalent stressors that may contribute to poor mental health and unhealthy habits. The purpose of this study was to determine the effect of sex and years of participation in collegiate marching band on the relationship between eating disorder risk and perceived stress levels. Methods: Marching artists from an NCAA Division I university completed the Eating Disorder Questionnaire-6 (EDEQ-6) and Perceived Stress Scale (PSS-10) to obtain disordered eating behaviors and perceived stress levels, respectively. Spearman rank correlations were used to determine the relationship between PSS-10 scores and global and subscale EDEQ-6 scores, …
Barriers To The Implementation Of The Amsterdam 2022 Statement In The Secondary School Setting, Luis Torres, Jennifer L. Baldari, Fredrick A. Gardin, August M. Price
Barriers To The Implementation Of The Amsterdam 2022 Statement In The Secondary School Setting, Luis Torres, Jennifer L. Baldari, Fredrick A. Gardin, August M. Price
Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association
Introduction: Athletic trainers are reasonably expected to evolve their concussion management protocols to better align themselves with the recommendations found in the Amsterdam 2022 Statement. Secondary school athletic trainers may lack the time, training, or resources to actualize these recommendations within their protocols. The purpose of this study was to identify the barriers associated with the implementation of the Amsterdam 2022 Statement recommendations in the secondary school setting. Methods: 89 secondary school ATs (44 males, 45 females) in the NATA District 1 and District 2 regions were provided with an electronic survey using Qualtrics (Qualtrics, Provo, UT), consisting of 6 …
Identifying Factors Associated With Sleep Disorders And Treatment Avoidance Among Collegiate Student-Athletes, Allie Ziniti, Andrew W. Froehle, Brian A. Edwards
Identifying Factors Associated With Sleep Disorders And Treatment Avoidance Among Collegiate Student-Athletes, Allie Ziniti, Andrew W. Froehle, Brian A. Edwards
Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association
Introduction: Mental health concerns among collegiate students-athletes are exacerbated by poor sleep, and this population experiences elevated risk for irregular sleep patterns and associated sleep disorders. Interventions aimed at early identification of student-athletes experiencing sleep disorders and guiding them to treatment can contribute to improved mental health in this group. The present study’s objective was to clarify risk-factors associated with increased likelihood of sleep disorders and treatment avoidance in student-athletes. Methods: Data were self-reported survey responses related to sleep disorders, from US college/university varsity athletes (n=51,882) completing the 2011-2019 National College Health Assessments (NCHA). Outcomes: The primary outcomes that we …
Access To Outreach Athletic Trainers Improves Orthopedic Specialty Appointment Adherence, Katie Sniffen, Katie Smith, Michael Rozier, Katherine Stamatakis, Paula Buchanan, Leslie Hinyard
Access To Outreach Athletic Trainers Improves Orthopedic Specialty Appointment Adherence, Katie Sniffen, Katie Smith, Michael Rozier, Katherine Stamatakis, Paula Buchanan, Leslie Hinyard
Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association
Background: Adolescent sports participation carries an inherent risk of musculoskeletal injury, with an estimated 2 million injuries occurring annually among high school athletes. Navigating the healthcare system to receive appropriate care can be challenging, potentially leading to delayed treatment and poorer outcomes. Athletic trainers (ATs) may play a crucial role in facilitating timely access to specialized care. The objective of this study was to assess the relationship between referral pathways (outreach athletic trainers (OATs), non-outreach athletic trainers (ATs), urgent care (UC), and emergency department (ED)) and appointment adherence while controlling for predisposing, enabling, and need factors. Methods: Using electronic medical …
Retention Of Cpr Knowledge And Skills Among Ncaa Division Iii Athletic Coaches: A Prospective Cohort Study, Allison Hanstine, Jaclyn Tate, Chyrsten Gessel
Retention Of Cpr Knowledge And Skills Among Ncaa Division Iii Athletic Coaches: A Prospective Cohort Study, Allison Hanstine, Jaclyn Tate, Chyrsten Gessel
Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association
Objective/Context: It is crucial for athletic coaches to be proficient in cardiopulmonary resuscitation (CPR) knowledge and skill performance for the health and safety of their athletes. This research aimed to assess CPR knowledge and CPR skill retention five months post-training among athletic coaches. In addition, the study assessed whether the number of years certified in CPR had an association with CPR skill performance scores five months post-training. Design and Setting: As a part of a master’s thesis, this prospective cohort study was performed over a five-month period to align with the research timeline. Participants: The study was conducted among 19 …
A Pilot Study: Effects Of 5-Week Hamstring Training On Functional Movement Screen Scores., Julie Landrigan, Colin Tomes
A Pilot Study: Effects Of 5-Week Hamstring Training On Functional Movement Screen Scores., Julie Landrigan, Colin Tomes
Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association
Introduction. The Functional Movement Screen (FMS) can be used by clinicians to assess movement and asymmetries in their clients. Understanding FMS composite and subtest scores can be a useful way for clinicians to monitor risk of injury. The purpose of this study was to identify if eccentric hamstring stretching and Nordic hamstring curls could improve movement, FMS scores, and active straight leg raise range of motion. Methods. Participants consisted of a convenience sample of high-school athletes. All subjects participated in the intervention, performing the FMS screen pre- and post-Nordic curls and stretching. Results. This pilot study suggests that the …
Normative Performance Test Metrics In Professional Female Club Soccer, Andy Seraphin, Christi Edson, Cory Price, Barrett Jones, Amanda Jagielo, Justin Mullner
Normative Performance Test Metrics In Professional Female Club Soccer, Andy Seraphin, Christi Edson, Cory Price, Barrett Jones, Amanda Jagielo, Justin Mullner
Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association
Objective: To establish normative ranges in common performance tests for professional women’s club soccer. Setting:1st division professional women’s soccer club in the United States
Participants: Twenty-eight healthy professional women’s soccer players (Age: 27.8 ± 5.1 years; Body Mass: 66.2 ± 6.7 kg). Main Outcome Measures: Countermovement Jump, Isometric Mid-Thigh Pull, and Nordic Hamstring Curl tests were performed to obtain lower body compound strength, power, and eccentric hamstring strength. Paired-samples t tests were used to determine between-limbs differences for each outcome measure. Results: Jump height had a mean of 28.9 ± 4.2 cm. Peak vertical force (IMTP) had a …
Relationship Between E-Sports And Physical Activity Participation: Validation Of The E-Sports Addiction Scale (Esas), Olivér Szabella, Lili Kassay, Attila Szabo
Relationship Between E-Sports And Physical Activity Participation: Validation Of The E-Sports Addiction Scale (Esas), Olivér Szabella, Lili Kassay, Attila Szabo
Baltic Journal of Health and Physical Activity
Background: E-sports are becoming increasingly popular. Considering the addictive potential of video games, e-sports might be more addictive than traditional sports. This study assessed the addiction risk in regular e-sports players and its relationship with other physical exercise habits. Method: A sample of 116 (93.1% males; mean age = 23.91±4.47) e-sports players answered questions online on play and exercise habits and completed the E-sports Addiction Scale (ESAS) derived from the revised Exercise Addiction Inventory (EAI-R). Results: The ESAS showed excellent model fit, allowing researchers to assess the risk of e-sports addiction in future studies. The risk rate of e-sports addiction …