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Articles 15121 - 15150 of 24913
Full-Text Articles in Medicine and Health Sciences
The Role Of Age, Experience, And Physical Fitness In Technical Performance In Karate: An Observational Analysis, Rui Miguel Silva, Joaquim Ferreira, Georgian Badicu, Jarosław Muracki, Beata Pożarowszczyk-Kuczko, Adam Kawczyński
The Role Of Age, Experience, And Physical Fitness In Technical Performance In Karate: An Observational Analysis, Rui Miguel Silva, Joaquim Ferreira, Georgian Badicu, Jarosław Muracki, Beata Pożarowszczyk-Kuczko, Adam Kawczyński
Baltic Journal of Health and Physical Activity
Background: This study aimed to investigate the relationships between age, experience, anthropometric measures, physical fitness, and the quality of technical performance in karate practitioners. We conducted an observational cross-sectional study with 53 federated karate athletes, aged 5 to 55, affiliated with the Youth Karate Association Portugal. The participants were divided into age and experience groups to assess differences in anthropometric measures (body mass, height, BMI) and physical fitness (strength, power, flexibility). The technical performance of four specific karate techniques – kizami, gyaku zuki, mawashi geri, and ura mawashi geri – was evaluated using a custom-designed technical evaluation …
Safety Study Of Polyunsaturated Fatty Acids Extracted From New Zealand Green Lipped Mussel And Krill On Hematology And Blood Chemistry Profiles Of Healthy Dogs And Cats, Uttra Jamikorn, Panumas Kongpanna
Safety Study Of Polyunsaturated Fatty Acids Extracted From New Zealand Green Lipped Mussel And Krill On Hematology And Blood Chemistry Profiles Of Healthy Dogs And Cats, Uttra Jamikorn, Panumas Kongpanna
The Thai Journal of Veterinary Medicine
New Zealand green-lipped mussel (Perna canaliculus) is a shellfish with a green shell containing many types of fatty acids, especially polyunsaturated fatty acids (PUFAs). The aim of the present study was to investigate the safety of dietary PUFAs supplementation on blood hematology, chemistry and coagulogram pancreatic enzymes in dogs and cats. Twelve healthy beagle dogs and healthy mature cats were used in these studies. Complete randomized block and triplicate 4×4 Latin square designs were used for these dog and cat safety studies, respectively. Experimental diets composed of sham control (0X) and 3 treatment groups, including 1X, 3X, and …
Ergonomic Consulting As Fieldwork: A Pandemic Need & Beyond, Sarah Klunk, Mba, Otr/L, Sara Loesche, Ms, Otr/L, Cht, Ceas
Ergonomic Consulting As Fieldwork: A Pandemic Need & Beyond, Sarah Klunk, Mba, Otr/L, Sara Loesche, Ms, Otr/L, Cht, Ceas
Department of Occupational Therapy Posters and Presentations
Background
In March of 2020, the COVID-19 pandemic impacted clinical and educational environments accessed by occupational therapy students. Educators had to reimagine learning in virtual spaces—including fieldwork education. At the same time, workers in many industries quickly pivoted from office spaces to a work from home (WFH) environment. Most workers had to navigate this transition without employer support—especially in larger companies (Voss et al., 2021).
This project was a collaboration between the academic fieldwork coordinator (AFWC) and a faculty member (fieldwork educator) who worked to identify a need for services as a result of the shift in work environments. Then, …
Backpacks & Beyond: Applying Ergonomic Principles To Promote Wellness For School Students And Staff, Sara Loesche, Ms, Otr/L, Cht, Ceas
Backpacks & Beyond: Applying Ergonomic Principles To Promote Wellness For School Students And Staff, Sara Loesche, Ms, Otr/L, Cht, Ceas
Department of Occupational Therapy Posters and Presentations
Overview
Students in elementary and secondary educational settings encounter ergonomic risk factors due to sedentary activity, poor postural habits, backpacks, and lack of knowledge related to health and wellness. Additionally, students are still physically developing during childhood and adolescent years.
An Occupational Therapy Intervention To Enhance Social And Physical Well-Being In Young Adults With First Episode Psychosis, Sarah Zagorac, Caitlin Taylor, Nuriya Neumann, Ilyse Kramer, Tina Deangelis
An Occupational Therapy Intervention To Enhance Social And Physical Well-Being In Young Adults With First Episode Psychosis, Sarah Zagorac, Caitlin Taylor, Nuriya Neumann, Ilyse Kramer, Tina Deangelis
Department of Occupational Therapy Posters and Presentations
Background
Can Occupational Therapy (OT) increase social participation, physical well-being, and functional recovery in young adults with psychosis?
- Early Intervention Services (EIS), including Coordinated Specialty Care programs (CSC), for young adults who experience a first episode of psychosis (FEP) have been shown to reduce hospitalizations, increase quality of life, and increase global functioning.1,2,3
- Young adults who experience FEP report a need to further address physical well-being and social participation, areas of life linked with long-term functional recovery.4,5,6
- Early evidence related to the COVID-19 pandemic demonstrates the disproportionate impact on underserved youth’s psychological well-being, including decreased social participation and …
"I Know Who I Am": Draw-And-Tell Conversations With Gender-Creative Children, Eline Leemans Lenne
"I Know Who I Am": Draw-And-Tell Conversations With Gender-Creative Children, Eline Leemans Lenne
Dissertations and Theses
A growing number of children identify in various gender-creative ways, likely due to broader social awareness and affirmation of transgenderism. Gender-creative children face higher risks for adverse social, academic, mental health, and healthcare outcomes compared to non-transgender peers. Support from loved ones along with guidance from pediatric providers can mitigate poor outcomes and ensure that gender-creative children live healthy and happy lives. Young gender-creative children's perspectives about the aforementioned topics are markedly absent from the literature, which instead highlights adolescent and adult proxy perspectives.
In this participatory arts-based study anchored by a constructivist epistemology and informed by post-structuralist, queer, and …
Medical School Watercooler Newsletter - April 3, 2025, Lindsay Hughes
Medical School Watercooler Newsletter - April 3, 2025, Lindsay Hughes
Watercooler Newsletter
This is the Thursday, April 3, 2025 edition of the Frederick P. Whiddon College of Medicine's newsletter -- Watercooler.
Contents include:
- USA scientist challenges study on mitochondrial DNA inheritance
- EDGE session focuses on communication, collaboration and 'Crucial Conversations'
- Whiddon COM hosts internal medicine meeting about precision healthcare
- 'IMPROV Your Networking' event builds student confidence, connection skills
- Medical student awarded scholarship from USA Department of Neurology
- Radiology residents receive Outstanding Trainee Poster Award at Southern Radiological Conference
The Relationship Between Fear Avoidance Beliefs And Low Back Pain In Crossfit Participants, Kyle Flaten
The Relationship Between Fear Avoidance Beliefs And Low Back Pain In Crossfit Participants, Kyle Flaten
Doctorate in Kinesiology
This study aimed to examine the relationships between fear avoidance, low back pain (LBP), and disability in CrossFit (CF) participants in the greater Twin Cities area in Minnesota with correlations between the Oswestry Disability Index (ODI), the Roland Morris Disability Questionnaire (RMDQ), and Fear Avoidance Belief Questionnaire for physical activity (FABQpa). 151 CF participants voluntarily completed the survey, including demographic information, LBP characteristics, the ODI, the RMDQ, and the FABQpa. Results showed that for CF participants with current LBP, duration had a large effect on fear avoidance (ɲ = .519 and ɲ2 = .269), and for those who reported a …
A Mapping Review And Critique Of The Literature On Translation, Dissemination, And Implementation Capacity Building Initiatives For Different Audiences, Ana A Baumann, Danielle R Adams, Laura-Mae Baldwin, Rachel G Tabak, Sara Malone, Maura M Kepper, Anita D Misra-Hebert, Kathleen R Stevens, Maria E Fernandez, Sunil Kripalani
A Mapping Review And Critique Of The Literature On Translation, Dissemination, And Implementation Capacity Building Initiatives For Different Audiences, Ana A Baumann, Danielle R Adams, Laura-Mae Baldwin, Rachel G Tabak, Sara Malone, Maura M Kepper, Anita D Misra-Hebert, Kathleen R Stevens, Maria E Fernandez, Sunil Kripalani
2020-Current year OA Pubs
BACKGROUND: Capacity building is critical for research and practice as the fields of dissemination, implementation and translation science continue to grow. Some scholars state that capacity building should be grounded in competencies. However, the fields are unclear in determining which competencies are relevant for whom, including the content and appropriate level of information and skills for different roles. The goal of this study was to catalogue competencies across current D&I capacity building initiatives.
METHODS: We conducted a mapping review to examine to what extent are theories or frameworks used to guide capacity building, who is being trained, to what extent …
De Novo Variants In Cdkl1 And Cdkl2 Are Associated With Neurodevelopmental Symptoms, Ali H Bereshneh, Jonathan C Andrews, Daniel F Eberl, Guney Bademci, Nicholas A Borja, Stephanie Bivona, Wendy K Chung, Shinya Yamamoto, Michael F Wangler, Shane Mckee, Mustafa Tekin, Hugo J Bellen, Oguz Kanca
De Novo Variants In Cdkl1 And Cdkl2 Are Associated With Neurodevelopmental Symptoms, Ali H Bereshneh, Jonathan C Andrews, Daniel F Eberl, Guney Bademci, Nicholas A Borja, Stephanie Bivona, Wendy K Chung, Shinya Yamamoto, Michael F Wangler, Shane Mckee, Mustafa Tekin, Hugo J Bellen, Oguz Kanca
Duncan NRI Faculty and Staff Publications
The CDKL (cyclin-dependent kinase-like) family consists of five members in humans, CDKL1-5, that encode serine-threonine kinases. The only member that has been associated with a Mendelian disorder is CDKL5, and variants in CDKL5 cause developmental and epileptic encephalopathy type 2 (DEE2). Here, we study four de novo variants in CDKL2 identified in five individuals, including three unrelated probands and monozygotic twins. These individuals present with overlapping symptoms, including global developmental delay, intellectual disability, childhood-onset epilepsy, dyspraxia, and speech deficits. We also identified two individuals with de novo missense variants in CDKL1 in the published Deciphering Developmental Disorders (DDD) and GeneDx …
Widespread Variation In Molecular Interactions And Regulatory Properties Among Transcription Factor Isoforms, Luke Lambourne, Kaia Mattioli, Clarissa Santoso, Gloria Sheynkman, Sachi Inukai, Babita Kaundal, Anna Berenson, Kerstin Spirohn-Fitzgerald, Anukana Bhattacharjee, Elisabeth Rothman, Shaleen Shrestha, Florent Laval, Brent S Carroll, Stephen P Plassmeyer, Ryan J Emenecker, Zhipeng Yang, Deepa Bisht, Jared A Sewell, Guangyuan Li, Anisa Prasad, Sabrina Phanor, Ryan Lane, Devlin C Moyer, Toby Hunt, Dawit Balcha, Marinella Gebbia, Jean-Claude Twizere, Tong Hao, Alex S Holehouse, Adam Frankish, Josh A Riback, Nathan Salomonis, Michael A Calderwood, David E Hill, Nidhi Sahni, Marc Vidal, Martha L Bulyk, Juan I Fuxman Bass
Widespread Variation In Molecular Interactions And Regulatory Properties Among Transcription Factor Isoforms, Luke Lambourne, Kaia Mattioli, Clarissa Santoso, Gloria Sheynkman, Sachi Inukai, Babita Kaundal, Anna Berenson, Kerstin Spirohn-Fitzgerald, Anukana Bhattacharjee, Elisabeth Rothman, Shaleen Shrestha, Florent Laval, Brent S Carroll, Stephen P Plassmeyer, Ryan J Emenecker, Zhipeng Yang, Deepa Bisht, Jared A Sewell, Guangyuan Li, Anisa Prasad, Sabrina Phanor, Ryan Lane, Devlin C Moyer, Toby Hunt, Dawit Balcha, Marinella Gebbia, Jean-Claude Twizere, Tong Hao, Alex S Holehouse, Adam Frankish, Josh A Riback, Nathan Salomonis, Michael A Calderwood, David E Hill, Nidhi Sahni, Marc Vidal, Martha L Bulyk, Juan I Fuxman Bass
Faculty, Staff and Students Publications
Most human transcription factor (TF) genes encode multiple protein isoforms differing in DNA-binding domains, effector domains, or other protein regions. The global extent to which this results in functional differences between isoforms remains unknown. Here, we systematically compared 693 isoforms of 246 TF genes, assessing DNA binding, protein binding, transcriptional activation, subcellular localization, and condensate formation. Relative to reference isoforms, two-thirds of alternative TF isoforms exhibit differences in one or more molecular activities, which often could not be predicted from sequence. We observed two primary categories of alternative TF isoforms: "rewirers" and "negative regulators," both of which were associated with …
The Effect Of Different Surface Treatments On The Roughness, Translucency, And Staining Of 3d-Printed Occlusal Device Materials, Silvia Rojas Rueda, Hanna Sepsick, Mohammed Hammamy, Amir H. Nejat, Edwin Kee, Nathaniel C. Lawson
The Effect Of Different Surface Treatments On The Roughness, Translucency, And Staining Of 3d-Printed Occlusal Device Materials, Silvia Rojas Rueda, Hanna Sepsick, Mohammed Hammamy, Amir H. Nejat, Edwin Kee, Nathaniel C. Lawson
School of Dentistry Faculty Publications
OBJECTIVES: To compare surface treatments (as-printed, optical polish, resin-coated, polished) of two 3D-printed occlusal device materials (KeySplint Soft and NightGuard Flex 2) cured with or without glycerin for surface roughness, translucency, and coffee staining. MATERIALS AND METHODS: Discs (2 mm thick) from two 3D-printed occlusal resins (KeySplint Soft and NightGuard Flex 2) were printed using a DLP 3D printer (SprintRay Pro 95), cleaned (ProWash S), and cured (ProCure 2) with or without glycerin. Some specimens were printed in an optical polish tank. Specimens were either as-printed, resin-coated, or polished. Reference milled (ProArt CAD Splint) and heat-cured (Excel Formula Heat Cure …
Chronic Alcohol Withdrawal-Associated Increases In Vta Hcrtr1 Expression Are Associated With Heightened Nociception And Anxiety-Like Behavior In Female Rats, Shealan Cruise, Maria E. Secci, Leslie K. Kelley, Nathan M. Sharfman, Keishla Rodriguez-Graciani, Tiffany A. Wills, Nicholas W. Gilpin, Elizabeth M. Avegno
Chronic Alcohol Withdrawal-Associated Increases In Vta Hcrtr1 Expression Are Associated With Heightened Nociception And Anxiety-Like Behavior In Female Rats, Shealan Cruise, Maria E. Secci, Leslie K. Kelley, Nathan M. Sharfman, Keishla Rodriguez-Graciani, Tiffany A. Wills, Nicholas W. Gilpin, Elizabeth M. Avegno
School of Medicine Faculty Publications
Alcohol withdrawal is characterized by various symptoms that include pain and negative affect in the absence of the drug. The neural underpinnings of these behaviors are not entirely understood, but orexin has emerged as a candidate target for the treatment of substance use disorders. Here, we explored changes in orexin system-related gene expression in brain regions important for mediating reward and stress, including the ventral tegmental area (VTA) and extended amygdala (including the central amygdala, nucleus accumbens shell, and bed nucleus of the stria terminalis), in adolescent and adult female Wistar rats following chronic alcohol exposure. We observed higher numbers …
A Mapping Review And Critique Of The Literature On Translation, Dissemination, And Implementation Capacity Building Initiatives For Different Audiences, Ana A Baumann, Danielle R Adams, Laura-Mae Baldwin, Rachel G Tabak, Sara Malone, Maura M Kepper, Anita D Misra-Hebert, Kathleen R Stevens, Maria E Fernandez, Sunil Kripalani
A Mapping Review And Critique Of The Literature On Translation, Dissemination, And Implementation Capacity Building Initiatives For Different Audiences, Ana A Baumann, Danielle R Adams, Laura-Mae Baldwin, Rachel G Tabak, Sara Malone, Maura M Kepper, Anita D Misra-Hebert, Kathleen R Stevens, Maria E Fernandez, Sunil Kripalani
Faculty, Staff and Student Publications
Background: Capacity building is critical for research and practice as the fields of dissemination, implementation and translation science continue to grow. Some scholars state that capacity building should be grounded in competencies. However, the fields are unclear in determining which competencies are relevant for whom, including the content and appropriate level of information and skills for different roles. The goal of this study was to catalogue competencies across current D&I capacity building initiatives.
Methods: We conducted a mapping review to examine to what extent are theories or frameworks used to guide capacity building, who is being trained, to what extent …
The Effects Of Diluted Fungicide On Western Tiger Salamander (Ambystoma Mavortium) Health, Sage Veomett
The Effects Of Diluted Fungicide On Western Tiger Salamander (Ambystoma Mavortium) Health, Sage Veomett
Honors Program: Senior Projects (Public)
The Western Tiger Salamander (Ambystoma mavortium) is a species of salamander that is native to Nebraska. The Western Tiger Salamander population has been in decline, specifically in Southeast Nebraska (Ferraro, 2016). The purpose of this study was to determine whether low levels of Azoxystrobin fungicide deposited in the soil are harmful to the Western Tiger Salamander. In this study, soil in tanks containing pairs of Western Tiger Salamanders was treated with levels of Azoxystrobin 0.5x under the recommended label amount for usage. Fifteen salamanders in total were used. Four tanks of salamander pairs were treated with the Azoxystrobin …
Hif Regulates Multiple Translated Endogenous Retroviruses: Implications For Cancer Immunotherapy, Qinqin Jiang, David A Braun, Karl R Clauser, Vijyendra Ramesh, Nitin H Shirole, Joseph E Duke-Cohan, Nancy Nabilsi, Nicholas J Kramer, Cleo Forman, Isabelle E Lippincott, Susan Klaeger, Kshiti M Phulphagar, Vipheaviny Chea, Nawoo Kim, Allison P Vanasse, Eddy Saad, Teagan Parsons, Melissa Carr-Reynolds, Isabel Carulli, Katarina Pinjusic, Yijia Jiang, Rong Li, Sudeepa Syamala, Suzanna Rachimi, Eva K Verzani, Jonathan D Stevens, William J Lane, Sabrina Y Camp, Kevin Meli, Melissa B Pappalardi, Zachary T Herbert, Xintao Qiu, Paloma Cejas, Henry W Long, Sachet A Shukla, Eliezer M Van Allen, Toni K Choueiri, L Stirling Churchman, Jennifer G Abelin, Cagan Gurer, Gavin Macbeath, Richard W Childs, Steven A Carr, Derin B Keskin, Catherine J Wu, William G Kaelin
Hif Regulates Multiple Translated Endogenous Retroviruses: Implications For Cancer Immunotherapy, Qinqin Jiang, David A Braun, Karl R Clauser, Vijyendra Ramesh, Nitin H Shirole, Joseph E Duke-Cohan, Nancy Nabilsi, Nicholas J Kramer, Cleo Forman, Isabelle E Lippincott, Susan Klaeger, Kshiti M Phulphagar, Vipheaviny Chea, Nawoo Kim, Allison P Vanasse, Eddy Saad, Teagan Parsons, Melissa Carr-Reynolds, Isabel Carulli, Katarina Pinjusic, Yijia Jiang, Rong Li, Sudeepa Syamala, Suzanna Rachimi, Eva K Verzani, Jonathan D Stevens, William J Lane, Sabrina Y Camp, Kevin Meli, Melissa B Pappalardi, Zachary T Herbert, Xintao Qiu, Paloma Cejas, Henry W Long, Sachet A Shukla, Eliezer M Van Allen, Toni K Choueiri, L Stirling Churchman, Jennifer G Abelin, Cagan Gurer, Gavin Macbeath, Richard W Childs, Steven A Carr, Derin B Keskin, Catherine J Wu, William G Kaelin
Faculty, Staff and Student Publications
Clear cell renal cell carcinoma (ccRCC), despite having a low mutational burden, is considered immunogenic because it occasionally undergoes spontaneous regressions and often responds to immunotherapies. The signature lesion in ccRCC is inactivation of the VHL tumor suppressor gene and consequent upregulation of the HIF transcription factor. An earlier case report described a ccRCC patient who was cured by an allogeneic stem cell transplant and later found to have donor-derived T cells that recognized a ccRCC-specific peptide encoded by a HIF-responsive endogenous retrovirus (ERV), ERVE-4. We report that ERVE-4 is one of many ERVs that are induced by HIF, translated …
Polygenic Score Analysis Identifies Distinct Genetic Risk Profiles In Alzheimer’S Disease Comorbidities, Carlos F Hernández, Camilo Villaman, Costin Leu, Dennis Lal, Ignacio Mata, Andrés D Klein, Eduardo Pérez-Palma
Polygenic Score Analysis Identifies Distinct Genetic Risk Profiles In Alzheimer’S Disease Comorbidities, Carlos F Hernández, Camilo Villaman, Costin Leu, Dennis Lal, Ignacio Mata, Andrés D Klein, Eduardo Pérez-Palma
Faculty, Staff and Student Publications
Alzheimer’s disease (AD) is usually accompanied by comorbidities such as type 2 diabetes (T2D), epilepsy, major depressive disorder (MDD), and migraine headaches (MH) that can significantly affect patient management and progression. As AD, these comorbidities have their own cumulative common genetic risk component that can be explored in a single individual through polygenic scores. Utilizing data from the UK Biobank, we investigated the correlation between polygenic scores (PGS) for these comorbidities and their actual presentation in AD patients. We show that individuals with higher PGS values showed an elevated risk of developing T2D (OR 2.1, p = 1.07 × 10−11) …
Efficacy Of Early Adl’S In The Post Operative Total Joint Replacement Population, Lee Ann Phillips Ms, Otr/L, Ryan Vetter Ms-Otr/L
Efficacy Of Early Adl’S In The Post Operative Total Joint Replacement Population, Lee Ann Phillips Ms, Otr/L, Ryan Vetter Ms-Otr/L
Department of Medicine
No abstract provided.
Biochemical Profiling And Structural Basis Of Adar1-Mediated Rna Editing, Xiangyu Deng, Lina Sun, Min Zhang, Rashmi Basavaraj, Jin Wang, Yi-Lan Weng, Yang Gao
Biochemical Profiling And Structural Basis Of Adar1-Mediated Rna Editing, Xiangyu Deng, Lina Sun, Min Zhang, Rashmi Basavaraj, Jin Wang, Yi-Lan Weng, Yang Gao
Faculty, Staff and Students Publications
ADAR1 regulates RNA-induced immune responses by converting adenosine to inosine in double-stranded RNA. Mutations in ADAR1 are associated with human autoimmune disease, and targeting ADAR1 has been proposed for cancer immunotherapy. However, the molecular mechanisms underlying ADAR1-mediated editing remain unclear. Here, we provide detailed biochemical and structural characterizations of human ADAR1. Our biochemical profiling reveals that ADAR1 editing is both sequence and RNA-duplex-length dependent but can well tolerate mismatches near the editing site. High-resolution ADAR1-RNA complex structures, combined with mutagenesis, elucidate RNA binding, substrate selection, dimerization, and the essential role of RNA-binding domain 3. The ADAR1 structures also help explain …
Open Access Dataset And Common Data Model For Pulse Oximeter Performance Data, Nicholas Fong, Michael S Lipnick, Ella Behnke, Yu Chou, Seif Elmankabadi, Lily Ortiz, Christopher S Almond, Isabella Auchus, Garrett W Burnett, Ronald Bisegerwa, Desireé R Conrad, Carolyn M Hendrickson, Shubhada Hooli, Robert Kopotic, Gregory Leeb, Daniel Martin, Eric D Mccollum, Ellis P Monk, Kelvin L Moore, Leonid Shmuylovich, J Brady Scott, An-Kwok Ian Wong, Tianyue Zhou, Romain Pirracchio, Philip E Bickler, John Feiner, Tyler J Law
Open Access Dataset And Common Data Model For Pulse Oximeter Performance Data, Nicholas Fong, Michael S Lipnick, Ella Behnke, Yu Chou, Seif Elmankabadi, Lily Ortiz, Christopher S Almond, Isabella Auchus, Garrett W Burnett, Ronald Bisegerwa, Desireé R Conrad, Carolyn M Hendrickson, Shubhada Hooli, Robert Kopotic, Gregory Leeb, Daniel Martin, Eric D Mccollum, Ellis P Monk, Kelvin L Moore, Leonid Shmuylovich, J Brady Scott, An-Kwok Ian Wong, Tianyue Zhou, Romain Pirracchio, Philip E Bickler, John Feiner, Tyler J Law
Faculty, Staff and Students Publications
The OpenOximetry Dataset stores clinical and lab pulse oximetry data. It supports measurements of arterial oxygen saturation (SaO2) by arterial blood gas co-oximetry and pulse oximetry (SpO2), alongside processed and unprocessed photoplethysmography (PPG) data and other metadata. This includes skin color measurements, finger diameter, vital signs (e.g., arterial blood pressure, end-tidal carbon dioxide), and arterial blood gas parameters (e.g., acid-base balance, hemoglobin concentration). All data, from desaturation studies to clinical trials, are collected prospectively to ensure accuracy. A common data model and standardized protocols for consistent archival and interpretation ensure consistent data archival and interpretation. The dataset aims to facilitate …
Clinical Validation Of Rna Sequencing For Mendelian Disorder Diagnostics, Sen Zhao, Kristina Macakova, Jefferson C Sinson, Hongzheng Dai, Jill Rosenfeld, Gladys E Zapata, Shenglan Li, Patricia A Ward, Christiana Wang, Chunjing Qu, Becky Maywald, Brendan Lee, Christine Eng, Pengfei Liu
Clinical Validation Of Rna Sequencing For Mendelian Disorder Diagnostics, Sen Zhao, Kristina Macakova, Jefferson C Sinson, Hongzheng Dai, Jill Rosenfeld, Gladys E Zapata, Shenglan Li, Patricia A Ward, Christiana Wang, Chunjing Qu, Becky Maywald, Brendan Lee, Christine Eng, Pengfei Liu
Faculty, Staff and Students Publications
Despite rapid advancements in clinical sequencing, over half of diagnostic evaluations still lack definitive results. RNA sequencing (RNA-seq) has shown promise in research settings for bridging this gap by providing essential functional data for accurate interpretation of diagnostic sequencing results. However, despite advanced research pipelines, clinical translation of diagnostic RNA-seq has not yet been realized. We have developed and validated a clinical diagnostic RNA-seq test for individuals with suspected genetic disorders who have existing or concurrent comprehensive DNA diagnostic testing. This diagnostic RNA-seq test processes RNA samples from fibroblasts or blood and derives clinical interpretations based on the analytical detection …
Nitrous Oxide Activates Layer 5 Prefrontal Neurons Via Sk2 Channel Inhibition For Antidepressant Effect, Joseph Cichon, Thomas T Joseph, Xinguo Lu, Andrzej Z Wasilczuk, Max B Kelz, Steven J Mennerick, Charles F Zorumski, Peter Nagele
Nitrous Oxide Activates Layer 5 Prefrontal Neurons Via Sk2 Channel Inhibition For Antidepressant Effect, Joseph Cichon, Thomas T Joseph, Xinguo Lu, Andrzej Z Wasilczuk, Max B Kelz, Steven J Mennerick, Charles F Zorumski, Peter Nagele
2020-Current year OA Pubs
Nitrous oxide (N
Breaking The Synaptic Vesicle Cycle: Mechanistic Insights Into Presynaptic Dysfunctions In Epilepsy, Kevin Jiang, Lu-Tang Yang, Mingshan Xue
Breaking The Synaptic Vesicle Cycle: Mechanistic Insights Into Presynaptic Dysfunctions In Epilepsy, Kevin Jiang, Lu-Tang Yang, Mingshan Xue
Duncan NRI Faculty and Staff Publications
Synaptic dysfunction is a hallmark of many neurological disorders including epilepsy. An increasing number of epilepsy-causing pathogenic variants are being identified in genes encoding presynaptic proteins that affect every step of the synaptic vesicle cycle, from vesicle loading, tethering, docking, priming, calcium sensing, fusing, to recycling. These different molecular dysfunctions result in converging impairment of presynaptic neurotransmitter release, yet lead to diverse epileptic disorders. This review focuses on representative monogenic epileptic disorders caused by pathogenic variants of key presynaptic proteins involved in different stages of the synaptic vesicle cycle: SYN1 (vesicle pool regulation), STXBP1 (vesicle docking, priming, and fusion), and …
Open Access Dataset And Common Data Model For Pulse Oximeter Performance Data, Nicholas Fong, Leonid Shmuylovich, Et Al.
Open Access Dataset And Common Data Model For Pulse Oximeter Performance Data, Nicholas Fong, Leonid Shmuylovich, Et Al.
2020-Current year OA Pubs
The OpenOximetry Dataset stores clinical and lab pulse oximetry data. It supports measurements of arterial oxygen saturation (SaO2) by arterial blood gas co-oximetry and pulse oximetry (SpO2), alongside processed and unprocessed photoplethysmography (PPG) data and other metadata. This includes skin color measurements, finger diameter, vital signs (e.g., arterial blood pressure, end-tidal carbon dioxide), and arterial blood gas parameters (e.g., acid-base balance, hemoglobin concentration). All data, from desaturation studies to clinical trials, are collected prospectively to ensure accuracy. A common data model and standardized protocols for consistent archival and interpretation ensure consistent data archival and interpretation. The dataset aims to facilitate …
Exploring The Impact Of Social Media And Social Networks On Juvenile Sexual Behavior Problems: A Scoping Review, Shaleen Clay
Exploring The Impact Of Social Media And Social Networks On Juvenile Sexual Behavior Problems: A Scoping Review, Shaleen Clay
LSU Master's Theses
The issue of juvenile problematic sexual behavior has become a pervasive problem, and little research exists on the topic. How social media and social networks impact problematic sexual behaviors in juveniles is even less known and understood. The objective of this scoping review was to determine what is known about the impact of social media and social networks on juvenile sexual behavior problems. Four key themes appeared in the literature including the use of adult terminology, rather than juvenile, to describe juvenile relationships; the normalization of abusive behaviors within adolescent relationship; the influence of social networks/peer groups on aggression and …
Growing The Good: A Communal Garden Case Study Among Marginalized, Rural Populations, Claire Barbier
Growing The Good: A Communal Garden Case Study Among Marginalized, Rural Populations, Claire Barbier
LSU Master's Theses
Community and Communal gardens (CG) have been documented as early as the late 1800s during periods of economic recessions and high food insecurity (The MIT Press Reader, 2022). However, C.G. adoption rates are expanding on a global scale as communities and municipalities see the potential for the tool to bring relief to environments in dire need of additional resources. Utilizing a communal garden can be used to address a surplus of systemic barriers a community faces; it has a significant opportunity to bring forth the interconnected tiers of public health altogether (Twiss et. al, 2003). Modernized C.G projects bring forth …
Oral Hygiene And Cardiovascular Health, Md. S. Zaman, S. M. Golam Alam, Mohammed S. Razzaque
Oral Hygiene And Cardiovascular Health, Md. S. Zaman, S. M. Golam Alam, Mohammed S. Razzaque
School of Medicine Publications
The human oral microbiome plays a vital role in maintaining oral and systemic health. This diverse microbial community includes over 700 bacterial species, some of which are implicated in developing systemic diseases, particularly cardiovascular diseases (CVDs). Research highlights a strong association between periodontal disease and increased cardiovascular risk, suggesting that good oral hygiene practices may reduce the incidence of CVDs. Porphyromonas gingivalis and Fusobacterium nucleatum drive chronic inflammation in periodontal disease; these bacteria can extend beyond the mouth and contribute to systemic inflammatory responses. The inflammatory factors, including C-reactive protein (CRP), interleukins (IL-1, IL-6), and tumor necrosis factor-alpha (TNF-α), damage …
Heroes At The Clinic, Dalila Ulloa Perez
Heroes At The Clinic, Dalila Ulloa Perez
FUSION
This project explores different themes of heroism as seen through comparing my volunteer experience at the Veterinary Clinic at the Avenues in Marietta with major works of World Literature. It is shown how dedicated and selfless the staff are, as well as how strong and content the animals are. It puts an emphasis on how little acts of service can truly make a meaningful impact as it helps to create a broader understanding of heroism in our society.
For this assignment, students were asked to examine modern and ancient literary definitions of heroism by completing community service hours in person …
Staff Education Program On Pressure Ulcer Prevention, Khadijah Y. Ndiaye
Staff Education Program On Pressure Ulcer Prevention, Khadijah Y. Ndiaye
Walden Dissertations and Doctoral Studies
This staff education program was aimed at improving pressure ulcer prevention practices in long-term care settings by increasing staff knowledge. Pressure ulcers remain a significant issue in long-term care facilities, leading to adverse patient outcomes and increased healthcare costs. Addressing this problem is critical within nursing practice to ensure patient safety, enhance quality care, and reduce preventable harm. The practice-focused question was: What is the effectiveness of a staff education program on pressure ulcer prevention in increasing staff knowledge in long-term care settings? The purpose of this doctoral project is to design and evaluate a comprehensive staff education intervention, incorporating …
Examining Hearing Protection Use In Applied Technology: Frequency, Barriers, And Evidence Of Hearing Loss, Brock Blessing, Cassi Pinto, Willow Ludwig, Blake Roth
Examining Hearing Protection Use In Applied Technology: Frequency, Barriers, And Evidence Of Hearing Loss, Brock Blessing, Cassi Pinto, Willow Ludwig, Blake Roth
SACAD: Scholarly Activities
This study investigated the prevalence of hearing protection usage among applied technology instructors and students and explored factors contributing to non-compliance. Survey data was collected in addition to the completion of basic audiometry screening procedures. Results indicated that while hearing protection devices were as readily available as head and eye protection, they were worn less frequently. Many participants found hearing protection inconvenient or believed it interfered with communication. A gap in education and resources was identified. These findings highlight the need for improved education and reinforcement of hearing conservation practices to increase compliance among applied technology instructors and students.