Medicine and Health Sciences Commons^™

The Relationship Between Maternal Dental Anxiety And Children's Dental Anxiety: A Cross-Sectional Study, Mariam I. Sharaf, Mayssoon A. Dashash

Arabian Journal of Pediatric Dentistry

Background and aim of the study: Dental fear and anxiety are one of the main challenges in pediatric dentistry, and dental fear and anxiety are a common reason for avoiding dental treatments, which may lead to deterioration of oral health status over time. Many researchers have shown that the relationship between parents and children has a direct impact on dental anxiety in children, so this study was conducted with the aim of evaluating the relationship between dental anxiety in mothers and dental anxiety in children.

Materials and methods: This cross-sectional study was conducted on 60 children and their mothers …

Evaluating The Effectiveness Of Cinnamon Oil On Pain Severity Caused By Needle Pick During Inferior Alveolar Nerve Block In Children, Hiba N. Khalouf, Mohammad Bashier Al Monaqel

Arabian Journal of Pediatric Dentistry

Objectives: Despite the great development witnessed by dentistry, pain during the insertion of a local anesthesia needle is still the main cause of fear and anxiety in children, and with the spread of many methods to relieve pain, research is still ongoing to find an effective surface anesthetic to relieve pain well, so the aim of this research was to take advantage of the available and cheap non-pharmacological natural materials in achieving this goal.

Materials and Methods: A randomized, double-blind clinical study was conducted involving 60 children from the Pediatric Dentistry Department of Damascus University. Cooperative children were selected …

Comparing Two Types Of Distraction (Passive And Active) During Primary Mandibular Molar Pulpotomy (Randomized Controlled Trial), Ekram A. Alsibai, Nada Bshara

Arabian Journal of Pediatric Dentistry

Objectives: The aim of this study was to compare the types of passive distraction - by watching cartoons - and active distraction - by video games - during pulpotomy on the primary mandibular molars in children.

Materials and Methods: The research sample consisted of 70 children who were randomly divided into two groups according to the distraction method used:

Group (1): 35 children who used the active distraction technique by video games through a wireless gaming handpiece.

Group (2): 35 children who used the passive distraction technique by watching cartoons films.

Children were selected from the Department of Pediatric Dentistry …

Impact Of An Oral Health Education Program On Institutionalized Visually Impaired Children In Syria, Batool M. Al Mughrabi, Yusra H. Haddeh, Mayssoon A. Dashash

Arabian Journal of Pediatric Dentistry

Background: Children with visually impairments encounter numerous challenges in maintaining adequate oral hygiene. Their reliance on caregivers limits their ability to utilize visual aids and engage with the medical instructions typically found in standard dental health education programs.

Aim: The aim of this study was to evaluate the effectiveness of oral health education (OHE) delivered through two different methods: audio and tactile, on the Knowledge – attitude – behavior (KAB) related to oral health, as well as the oral health status of visually impaired children.

Material and Methods: A total of sixty-six visually impaired children, aged 5-18 years, residing at …

Heterozygous Hereditary Vitamin D-Dependent Rickets Type 2a (Vddr2a) In A Patient Presenting With Pseudoarthrosis, Risa Goldberg, Gunjan Umarji, Serge Jabbour

Division of Endocrinology, Diabetes and Metabolic Diseases Faculty Papers

This case report is centered on an atypical presentation of Hereditary Vitamin D-dependent Rickets 2A (VDDR2A), a rare disorder caused by defects in the gene encoding the vitamin D receptor (VDR). While this disorder is primarily autosomal recessive in inheritance, this case demonstrates that a single heterozygous variant in the VDR gene could be linked to both phenotypic and laboratory manifestations of this condition. To understand the pathogenesis of this condition, one must know the typical roles of vitamin D, calcium, and parathyroid hormone (PTH) in maintaining homeostasis in the body. This case report focuses on the underlying pathogenesis of …

Hdac5 Enzymatic Activity Regulates Scn4b Expression To Control Relapse-Like Cocaine Seeking, Daniel J. Wood

MUSC Theses and Dissertations

Substance Use Disorder (SUD) is a relapsing disorder characterized by repeated seeking and use of psychoactive substances despite negative consequences to the individual. Epigenetic changes within the medium spiny neurons (MSNs) of the nucleus accumbens (NAc) are thought to underly the lasting propensity to relapse in SUD. The epigenetic enzyme histone deacetylase 5 (HDAC5) in NAc MSNs limits the formation of reward-cue associations in rodent models of drug seeking, but not sucrose seeking, leading to decreased relapse-like behavior. However, whether HDAC5 reduces drug seeking behavior through its own deacetylase activity or through the recruitment of co-repressors is unknown. Furthermore, these …

Ready To Shine: A Framework For Coaching K-12 Educators To Support Diverse Learners, Kathleen Childs, Angela Blackwell, Katie Gebhart

Spring 2025 OTD Capstone Symposium

The Ready to Shine: A Framework for Coaching K-12 Educators to Support Diverse Learners is meant to guide occupational therapy practitioners in training and coaching educators to implement strategies to support students with social-emotional, behavioral, sensory, or other unique needs. Through this framework, practitioners will aim to equip educators with the confidence, self-efficacy, and competence to use tools and/or techniques that promote participation and performance among their students.

An Independent Living Skills Training Guide For Direct Support Professionals Working With People With Intellectual Or Developmental Disabilities, Nigel Yeo, Steven Gerardi Phd, Otd, Mss, Otr

Spring 2025 OTD Capstone Symposium

Direct Support Professionals (DSPs) serve an important role in assisting people with intellectual and developmental disabilities (IDD) in many aspects of their lives through the provision of care and support. Despite lacking in knowledge and training to support the potentially complex and varied presentation of people with IDD, DSPs are in a position to help their clients address and improve on their independent living skills that are important for autonomy and overall well-being. The capstone project developed the Independent Living Skills Teaching Guide (ILSTG), as a tool for DSPs, containing activity plans related to independent living skills, activity modifications based …

Building Bridges: A Community Health Worker Training Course, Taylor A. Ramsey, Lesley Khan-Farooqi, Phd, Otd, Otr, Dr. Sharita Ambrose, Dhed., Mph, Ches, Chwi

Spring 2025 OTD Capstone Symposium

Building Bridges: A Community Health Worker Training Course is a comprehensive 20-hour continuing education course designed for community health workers (CHWS) who work with Black pregnant women. This training course was developed for and in collaboration with Allure Alliance Incorporated, a non-profit organization whose mission is to improve the lives of Black women through community programming, education, and advocacy. This training course reflects an interprofessional collaborative approach to addressing the racial disparities in the Black maternal health population in the U.S. The course includes evidence-based strategies and health management interventions derived from the Occupational Therapy Practice Framework, 4th Edition (OTPF-4), …

Enhancing Concussion Management: Addressing The Needs Of Student-Athletes, Coaches, And Occupational Therapy Practitioners, Anya Vernon, Lesley Khan-Farooqi, Tyra Lea

Spring 2025 OTD Capstone Symposium

There are limited educational resources available on concussion management for occupational therapy practitioners, coaches, and student-athletes which can limit access to comprehensive occupational therapy services for clients who have sustained a concussion, ultimately hindering participation in sport and overall wellbeing. The purpose of this capstone was to develop a comprehensive guidebook for coaches and student-athletes and a comprehensive handbook for occupational therapy practitioners to raise awareness in concussion education and clarify occupational therapy's role on a multidisciplinary concussion management team. This project addresses the growing need for concussion education among student-athletes and coaches, improves understanding of concussion signs and symptoms, …

The Role Of Occupational Therapy In The Care Of Informal Caregivers Of People With Dementia: A Concept Analysis, Ashley M. Taylor, Steven M. Gerardi, Elizabeth Deluca-Berg

Spring 2025 OTD Capstone Symposium

Informal caregivers (care partners) are people, such as family members, who provide care to those who cannot care for themselves, including people with dementia (PwD). Care partners assist PwD in their daily occupations, often without training. Caring for PwD can lead to emotional, physical, financial, and occupational challenges for care partners. Occupational therapy (OT) has a role to play in the care of PwD. However, if clinicians do not operate from a dyadic model, care partners’ needs may be overlooked. Problem: Although addressing the care partner dyad is important to the delivery of OT, the role of OT in the …

Enhancing Psychosocial Well-Being For Pediatric Oncology Clients: A Guidebook For Occupational Therapists, Marzia Khan, Lesley Khan-Farooqi, Brooke Weber

Spring 2025 OTD Capstone Symposium

This capstone project addressed the critical gap in psychosocial support for pediatric oncology clients by developing an evidence-based guidebook for occupational therapy (OT) practitioners. Grounded in the Model of Human Occupation (MOHO), the guidebook provides therapists with developmentally appropriate strategies to enhance emotional regulation, social participation, and engagement in meaningful activities for children aged 3 to 12 undergoing cancer treatment. The project identified key psychosocial challenges through qualitative interviews, needs assessments, and real-time clinical feedback and designed targeted interventions aligned with OT principles. The digital guidebook provides accessible, structured resources to support holistic, client-centered care and improve the quality of …

Optimizing Care For Heart Failure Patients With Reduced Ejection Fraction: A Quality Improvement Project On Guideline Directed Medical Therapy Adherence, Leonie Campbell-Williams

DNP Projects

Significance and Background: Heart failure with reduced ejection fraction (HFrEF) remains a major cause of hospital readmissions, increasing both healthcare utilization and patient morbidity. Guideline-Directed Medical Therapy (GDMT) has been proven to reduce mortality and hospitalizations; however, adherence to these evidence-based guidelines remains inconsistent (Yancy et al., 2022).

Purpose: This quality improvement project aimed to evaluate whether enhancing GDMT adherence in an outpatient heart failure clinic could reduce emergency room (ER) admissions among patients with HFrEF.

Methods: A structured intervention was implemented at a local healthcare system Cardiology Clinic, focusing on optimizing adherence to GDMT in 60 patients with HFrEF. …

The Impact Of Digital Inequities On Oropharyngeal Cancer Disparities In The United States, David J. Fei-Zhang, Achilles A. Kanaris, Camaren M. Cuenca, Sydney A. Fleishman, Jill N. D'Souza, Anthony M. Sheyn, Daniel C. Chelius, Jeffrey C. Rastatter

School of Medicine Faculty Publications

Objective: To assess associations of digital inequity with oropharyngeal cancer (OPC) prognostic and care outcomes in the United States while adjusting for traditional social determinants/drivers of health (SDoH). Study Design: Retrospective cohort study. Setting: United States. Methods: In total, 70,604 patients from 2008 to 2017 were assessed for regression trends in long-term follow-up period, survival, prognosis, and treatment across increasing overall digital inequity, as measured by the Digital Inequity Index (DII). DII is based on 17 census-tract level variables derived from the American Community Survey and Federal Communications Commission. Variables were categorized as infrastructure-access (ie, digital-related variables) or sociodemographic (ie, …

Occupational Therapy In Upper Limb Loss, Prosthetics, And Rehabilitation: A Video Training Series For Entry-Level Occupational Therapy Practitioners, Bailey M. Brown, Lesley Khan-Farooqi

Spring 2025 OTD Capstone Symposium

The purpose of this capstone project was to deepen my understanding of upper limb prosthetics, observe patient care, and identify gaps in occupational therapy education related to upper limb loss, prosthetic use, and rehabilitation. A key objective was to support the Hanger Clinic by increasing the number of completed Upper Limb Prosthetic User Outcome Forms, as well as to capture photos and videos—separate from this video training series—to contribute to Hanger’s educational library. Additionally, the project aimed to develop practical resources for both patients and clinicians navigating upper limb loss. Insights gained throughout this experience informed the creation of a …

Sound Asleep: A Manual For Occupational Therapy Practitioners (Otp) Addressing Sleep-Related Challenges In Young Children, Lorie-Ann Love, Ellen M. Pope Otd, Otr/L, Angela L. Blackwell Phd, Otr

Spring 2025 OTD Capstone Symposium

This capstone project sought to address the limited competence and confidence of occupational therapy practitioners (OTP) in providing services for children and families facing sleep-related challenges. The objective was to enhance OTP knowledge and skills in delivering specialized sleep interventions through the development of an educational resource. The project was implemented across two settings: telehealth and an outpatient pediatric service, integrating both virtual and outdoor environments for occupational therapy (OT). Participants include OTP, OT students, and families of young children (ages 0-5) experiencing sleep disturbances.

The project followed a structured four-phase approach: strengths and needs assessment, development of an educational …

Learning What To Say Through Theater And Play: A Theater Arts Communication And Conflict Resolution Program For Neurodivergent Children, Elena Corsair, Steven M. Gerardi

Spring 2025 OTD Capstone Symposium

Joshua’s Stage is a theater-based enrichment program for children with special needs. Joshua’s Stage provides developmentally appropriate activities for their students, but they do not address clinical or functional problems. Problem: Joshua’s Stage does not provide specialized programming to meet the needs of neurodivergent children with communication problems and conflict resolution, making it difficult for these children to participate fully. Purpose: The purpose of this project was to create a theater arts communication and conflict resolution program for neurodivergent children to be integrated into Joshua’s Stage enrichment program. A four-week program, consisting of eight sessions, was developed over a 14-week …

The Role Of Occupational Therapy In Bladder And Bowel Management For Individuals With Spinal Cord Injuries: An Educational Video Series, Julia Ryan, Steven Gerardi, Heather Rennerfeldt

Spring 2025 OTD Capstone Symposium

Occupational therapy (OT) practitioners are uniquely positioned to support individuals with spinal cord injury (SCI) in developing effective bowel and bladder management (BBM) routines. However, most existing literature approaches BBM from a medical perspective, offering limited guidance on how to translate occupation-based strategies into OT practice. This lack of discipline-specific resources contributes to reduced confidence among generalist practitioners and hinders the consistent implementation of BBM interventions across inpatient and community settings. To address this gap, a nine-part educational video series was developed to enhance OT practitioners’ knowledge, clinical reasoning, and confidence in delivering BBM interventions for clients with SCI. The …

Graded Habilitation Activities For Direct Support Professionals: An Educational Video Series, Christi Cantu, Steven M. Gerardi, Daniel J. Burt

Spring 2025 OTD Capstone Symposium

This capstone project was created for direct support professionals (DSPs) to have a new resource for education and training on how to properly apply the concept of graded habilitation activities based on the Allen’s cognitive levels to the DSPs sessions. This capstone project was a need in the DSP community for DSPs provide direct care to people with intellectual or development disabilities (IDD). Therefore, this capstone project supports education and training DSPs need to optimally apply graded habilitation activities, based on participants’ cognitive level, to provide optimal services for people with IDD. Problem: DSPs lack knowledge of and education/training …

Bridges To Asd: Building Resilience, Self-Efficacy And Capacity In Belizean Caregivers Of Children With Autism Spectrum Disorder (Asd), Katherine B. Anderton, Amy Satterthwaite, Angela Labrie Blackwell

Spring 2025 OTD Capstone Symposium

The Bridges to ASD program was a capstone project that contributed to the nonprofit clinic in a developing country by providing resources and training sessions that potentially helped to unify the caregivers, the teachers and the therapists in their common goals to better support their children in the community with ASD.

Occupational Therapy For Participation In Spirituality For Individuals With Cancer: A Scoping Review, Natalie Fernandez, Lesley Khan-Farooqi, Steven Gerardi

Spring 2025 OTD Capstone Symposium

The incidence of cancer continues to rise. For many individuals with cancer, spirituality is an important part of life. Spirituality impacts the individual’s meaning, purpose, self-identity, occupational engagement, occupational performance, and quality of life. However, there are sometimes barriers to participation in religions activities. Occupational therapy (OT) is indicated when people have barriers to participation. However, spirituality is not consistently addressed in OT practice and OT practitioners may not feel comfortable in addressing barriers to participation in spiritual activities among their clients with cancer. Objective: Scoping review methodology was used to answer the research question, how are OT practitioners addressing …

A Training Toolkit For Introducing Stem Cell Transplantation To The Inpatient Oncology Nurse, Susan G. Berg Bsn, Rn, Cmsrn, Ocn, Jenna Ruggiero Bsn, Rn, Jordan Mellinger Kish Msn, Rn, Lisa Russo Msn, Rn, Gavin Bauer Bsn, Rn, Tammy Selby Rn

Hematology-Medical Oncology Division

No abstract provided.

Planning And Dissemination Of Quality Improvement Activities: A Qualitative Study Evaluating Barriers And Enablers To Implementation Of The Squire 2.0 Guidelines, Jessica Rose Phillips

Doctor of Philosophy in Translational Health Sciences Dissertations

Background: Quality improvement (QI) initiatives aim to systematically improve the efficiency and safety of healthcare provided to patients. These data-driven projects also seek to improve processes within the healthcare industry. Potential goals for quality improvement projects (QIPs) can include improving patient outcomes, improving healthcare access, increasing efficiency, and enhancing patient safety. While essential to improve care at the local level, QIPs are not without challenges. Currently, healthcare organizations plan and report the findings of these QIPs in non-standardized ways. This can lead to missing key details and the sharing of inaccurate results, among other things. The Standards for Quality Improvement …

The Association Of Sleep Quality And Depression On Having Three Vs. All Five Diagnostic Criteria Of Metabolic Syndrome, Nina Pollard

Walden Dissertations and Doctoral Studies

Metabolic syndrome is increasing in prevalence in the United States. To be diagnosed, three of the five diagnostic criteria must be met. There is a higher risk of metabolic syndrome due to lifestyle and social factors, with increased criteria occurring as an individual has unmet social determinants of health. This quantitative quasi-experimental/quasi-comparative study examined the association between education level, with sleep quality and depression as moderators, on a diagnosis of metabolic syndrome with all five criteria versus three criteria using a binary logistic regression while controlling for age, race, gender, income, employment, and marital status. Bronfenbrenner’s social ecological theory served …

Association Of Clonal Hematopoiesis Of Indeterminate Potential With Cardiovascular Events In Patients With Ckd, James E Hixson, Do-Kyun Kim, Alexander Bick, Bryan Kestenbaum, Michael Chong, Guillaume Paré, Michael Rauh, Adeera Levin, James P Lash, Manjula Kurella Tamura, Debbie L Cohen, Jiang He, Lee Hamm, Rajat Deo, Zeenat Bhat, Panduranga Rao, Dawei Xie, Pradeep Natarajan, Cassianne Robinson-Cohen, Matthew B Lanktree

Faculty, Staff and Student Publications

Key Points:

1. In patients with CKD, non-DNMT3A clonal hematopoiesis of indeterminate potential (CHIP) was associated with higher risk of cardiovascular events.

2. There was no significant difference in the CHIP–cardiovascular disease association based on baseline eGFR, diabetes status, or race.

3. The protective effect of IL6R p.Asp358Ala on non-DNMT3A CHIP cardiovascular risk was similar to the general population.

Background: Patients with CKD are at higher risk of cardiovascular disease. Clonal hematopoiesis of indeterminate potential (CHIP) has been associated with cardiovascular disease in the general population, with a causal role observed in animal models. In the general population, the effect of …

The Medial Olivocochlear Efferent Pathway Potentiates Cochlear Amplification In Response To Hearing Loss, Ariadna Cobo-Cuan, Marcela A Morán, Bong Jik Kim, Clayton B Walker, Michael J Serafino, Frank Macias-Escriva, Juemei Wang, James B Dewey, Brian E Applegate, Matthew J Mcginley, John S Oghalai

Faculty, Staff and Students Publications

The mammalian cochlea receives efferent feedback from the brain. Many functions for this feedback have been hypothesized, including on short timescales, such as mediating attentional states, and long timescales, such as buffering acoustic trauma. Testing these hypotheses has been impeded by an inability to make direct measurements of efferent effects in awake animals. Here, we assessed the role of the medial olivocochlear (MOC) efferent nerve fibers on cochlear amplification by measuring organ of Corti vibratory responses to sound in both sexes of awake and anesthetized mice. We studied long-term effects by genetically ablating the efferents and/or afferents. Cochlear amplification increased …

Mitochondrial Responses To Conventional And Ultra-High Dose Rate (Flash) Radiation, Kevin Liu, Henry Gatica-Gutierrez, Sofía Vargas-Hernández, Nefetiti Mims, Ariana Acevedo-Diaz, Brett Velasquez, Denae Neil, Edgardo Aguilar, Matthew D Meyer, Gloria V Echeverria, Albert C Koong, Michael T Spiotto, Anna-Karin Gustavsson, Emil Schüler

Faculty, Staff and Students Publications

Purpose: Ultra-high dose rate (>40 Gy/s, FLASH) radiation therapy (RT) provides equivalent tumor control while reducing normal tissue toxicity relative to conventional dose rate (CONV) RT. However, the mechanisms underlying the observed FLASH effect are unknown. We hypothesized that the preservation of mitochondrial integrity in nontumorigenic cells by FLASH RT could be a key factor in reducing normal tissue toxicity and improving overall treatment outcomes.

Methods: We examined mitochondrial health and function after CONV and FLASH in vitro, ex vivo, and in vivo through assays of metabolic flux, mitochondrial membrane potential, mitochondrial reactive oxygen species (ROS), mitochondrial DNA damage …

An Unsupervised Map Of Excitatory Neuron Dendritic Morphology In The Mouse Visual Cortex, Timo Lüddecke, Brendan Celii, Paul G Fahey, Eric Y Wang, J Alexander Bae, Agnes L Bodor, Derrick Brittain, Joann Buchanan, Daniel J Bumbarger, Manuel A Castro, Forrest Collman, Nuno Maçarico Da Costa, Sven Dorkenwald, Leila Elabbady, Akhilesh Halageri, Zhen Jia, Chris Jordan, Dan Kapner, Nico Kemnitz, Sam Kinn, Kisuk Lee, Kai Li, Ran Lu, Thomas Macrina, Gayathri Mahalingam, Eric Mitchell, Shanka Subhra Mondal, Shang Mu, Barak Nehoran, Sergiy Popovych, R Clay Reid, Casey M Schneider-Mizell, H Sebastian Seung, William Silversmith, Marc Takeno, Russel Torres, Nicholas L Turner, William Wong, Jingpeng Wu, Wenjing Yin, Szi-Chieh Yu, Jacob Reimer, Philipp Berens, Andreas S Tolias, Alexander S Ecker

Faculty, Staff and Students Publications

Neurons in the neocortex exhibit astonishing morphological diversity, which is critical for properly wiring neural circuits and giving neurons their functional properties. However, the organizational principles underlying this morphological diversity remain an open question. Here, we took a data-driven approach using graph-based machine learning methods to obtain a low-dimensional morphological "bar code" describing more than 30,000 excitatory neurons in mouse visual areas V1, AL, and RL that were reconstructed from the millimeter scale MICrONS serial-section electron microscopy volume. Contrary to previous classifications into discrete morphological types (m-types), our data-driven approach suggests that the morphological landscape of cortical excitatory neurons is …

Co-Designing A Web-Based And Tablet App To Evaluate Clinical Outcomes Of Early Psychosis Service Users In A Learning Health Care Network: User-Centered Design Workshop And Pilot Study, Kathleen E Burch, Adam B Wilcox, Et Al.

2020-Current year OA Pubs

BACKGROUND: The Early Psychosis Intervention Network of California project, a learning health care network of California early psychosis intervention (EPI) programs, prioritized incorporation of community partner feedback while designing its eHealth app, Beehive. Though eHealth apps can support learning health care network data collection aims, low user acceptance or adoption can pose barriers to successful implementation. Adopting user-centered design (UCD) approaches, such as incorporation of user feedback, prototyping, iterative design, and continuous evaluation, can mitigate these potential barriers.

OBJECTIVE: We aimed to use UCD during development of a data collection and data visualization web-based and tablet app, Beehive, to promote …

Activation Of Endoplasmic Reticulum-Localized Metabotropic Glutamate Receptor 5 (Mglu5) Triggers Calcium Release Distinct From Cell Surface Counterparts In Striatal Neurons, Yuh-Jiin I Jong, Steven K Harmon, Karen L O'Malley

2020-Current year OA Pubs

Metabotropic glutamate receptor 5 (mGlu