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2025

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Articles 10561 - 10590 of 24914

Full-Text Articles in Medicine and Health Sciences

Home-Based Transcranial Direct Current Stimulation For Major Depressive Disorder: 6-Month Follow-Up From Randomised Sham-Controlled Trial And Open-Label Treatment Phases, Rachel D Woodham, Sudhakar Selvaraj, Nahed Lajmi, Harriet Hobday, Gabrielle Sheehan, Ali-Reza Ghazi-Noori, Peter J Lagerberg, Rodrigo Machado-Vieira, Jair C Soares, Allan H Young, Cynthia H Y Fu Jun 2025

Home-Based Transcranial Direct Current Stimulation For Major Depressive Disorder: 6-Month Follow-Up From Randomised Sham-Controlled Trial And Open-Label Treatment Phases, Rachel D Woodham, Sudhakar Selvaraj, Nahed Lajmi, Harriet Hobday, Gabrielle Sheehan, Ali-Reza Ghazi-Noori, Peter J Lagerberg, Rodrigo Machado-Vieira, Jair C Soares, Allan H Young, Cynthia H Y Fu

Faculty, Staff and Student Publications

Transcranial direct current stimulation (tDCS) is a potential home-based treatment for major depressive disorder (MDD). In our double-blind randomised controlled trial (RCT) (n = 174; UK and USA), a 10-week course of home-based tDCS demonstrated clinical efficacy (clinical response: 58.3 % active treatment arm and 37.8 % sham (p = 0.017). tDCS was delivered in a bifrontal montage, with anode over left dorsolateral prefrontal cortex (DLPFC) and cathode over right DLPFC. Each session was 30 min, with active stimulation at 2 mA and sham at 0 mA, incorporating brief ramp-up and ramp-down phased. Following the 10-week RCT, all participants were …


Emerging Technologies Of Single-Cell Multi-Omics, Yi June Kim, Koichi Takahashi Jun 2025

Emerging Technologies Of Single-Cell Multi-Omics, Yi June Kim, Koichi Takahashi

Faculty, Staff and Student Publications

The heterogeneity of the hematopoietic system was largely veiled by traditional bulk sequencing methods, which measure the averaged signals from mixed cellular populations. In contrast, single-cell sequencing has enabled the direct measurement of individual signals from each cell, significantly enhancing our ability to unveil such heterogeneity. Building on these advances, numerous single-cell multi-omics techniques have been developed into high-throughput, routinely accessible platforms, delineating the precise relationships among different layers of the central dogma in molecular biology. These technologies have uncovered the intricate landscape of genetic clonality and transcriptional heterogeneity in both normal and malignant hematopoietic systems, highlighting their roles in …


Cost Savings Associated With Aspirin Deprescribing Among Patients Receiving Warfarin, Virginia Falvello, Geoffrey D. Barnes, Josh Errickson, Xiaokui Gu, Ang Li, Mona Ali, Brian Haymart, Scott Kaatz, James B. Froehlich, Bonnie Cheng, Michael Thompson, Jordan Schaefer Jun 2025

Cost Savings Associated With Aspirin Deprescribing Among Patients Receiving Warfarin, Virginia Falvello, Geoffrey D. Barnes, Josh Errickson, Xiaokui Gu, Ang Li, Mona Ali, Brian Haymart, Scott Kaatz, James B. Froehlich, Bonnie Cheng, Michael Thompson, Jordan Schaefer

Conference Presentation Abstracts

Background : From 2017-2018 the Michigan Anticoagulation Quality Improvement Initiative (MAQI2) implemented a multicenter quality improvement project to improve guideline concordant aspirin use among warfarin treated patients with atrial fibrillation and/or venous thromboembolic disease. After 48 months of follow-up, this intervention was associated with reduced bleeding but no increase in thrombosis. The cost savings of this intervention has not been assessed. Aims : To determine insurance payments associated with adverse bleeding and thrombotic events and estimate the potential reduction in payments associated with aspirin deprescribing. Methods : Insurance reimbursement data from the MAQI2 cohort was identified by perfect match of …


Long Term Outcomes Of A Multicenter Aspirin Deprescribing Intervention, Avilasha Sinha, Josh Errickson, Xiaokui Gu, Mona Ali, Christopher Giuliano, Brian Haymart, Scott Kaatz, Deborah Decamillo, Noelle Ryan, James Froehlich, Geoffrey Barnes, Jordan Schaefer Jun 2025

Long Term Outcomes Of A Multicenter Aspirin Deprescribing Intervention, Avilasha Sinha, Josh Errickson, Xiaokui Gu, Mona Ali, Christopher Giuliano, Brian Haymart, Scott Kaatz, Deborah Decamillo, Noelle Ryan, James Froehlich, Geoffrey Barnes, Jordan Schaefer

Conference Presentation Abstracts

Background : From 2017 – 2018, the Michigan Anticoagulation Quality Improvement Initiative (MAQI2) implemented a multicenter quality improvement project to reduce excess aspirin use among patients on warfarin. Analysis 24 months post-intervention showed significant reductions in aspirin use and the intervention was associated with improved bleeding outcomes. It was unclear if these outcomes would be sustained. Aims : To evaluate pre- and post- intervention aspirin use, bleeding, and thrombotic outcomes, now with up to 84 months of follow-up data. Methods : Included patients were adults on long-term warfarin for atrial fibrillation and/or venous thromboembolism without an apparent indication for aspirin. …


Validity And Reliability Of The Tampa Scale For Kinesiophobia For Adolescents With Heart Disease., David A. White, William R. Black, Emily Cramer, Lindsey Malloy-Walton, Mollie Walton, Laura Martis, Brandy Enneking, Kelli M. Teson, Jessica S. Watson, Jami Gross-Toalson Jun 2025

Validity And Reliability Of The Tampa Scale For Kinesiophobia For Adolescents With Heart Disease., David A. White, William R. Black, Emily Cramer, Lindsey Malloy-Walton, Mollie Walton, Laura Martis, Brandy Enneking, Kelli M. Teson, Jessica S. Watson, Jami Gross-Toalson

Manuscripts, Articles, Book Chapters and Other Papers

PURPOSE: To assess the validity and reliability of a newly adapted Tampa Scale for KP for adolescents with HD (TSK-Heart-A).

METHODS: The TSK-Heart-A survey consists of 17 Likert scale items, producing a summary score (SS) ranging from 17 (low KP) to 68 (high KP). Following content and face validity, adolescents (age 12-18 yr) with arrhythmia disorders or Fontan palliation were recruited. The PROMIS pediatric anxiety and depression short forms, Pediatric Quality of Life Inventory (PedsQL) generic core and cardiac module, and a PA questionnaire for adolescents (PAQ-A) were used for criterion validity. The TSK-Heart-A was completed twice (20.4 ± 6.3 …


Adapting To Hyflex Delivery, Therese M. Murphy Jun 2025

Adapting To Hyflex Delivery, Therese M. Murphy

Case studies: Digital Education

I deliver a face-to-face Bioinformatics module to third-year TU866 students. This module includes online, open-book, summative quizzes following each workshop. On one occasion a student was unable to attend a workshop and quiz session due to testing positive for COVID-19. Although the student was asymptomatic, she chose to avoid potentially spreading the virus to her peers. In response, I promptly adapted the workshop and assessment to a hyflex delivery format. The student participated online with her camera on via Bongo. The student attended the workshop and completed the quiz online, in parallel with their classmates. The quiz, being open-book but …


Flexible Pathways In Medical Science - Evaluating The Impact Of Hyflex Teaching Modes, Aine Balfe Jun 2025

Flexible Pathways In Medical Science - Evaluating The Impact Of Hyflex Teaching Modes, Aine Balfe

Case studies: Digital Education

The HyFlex teaching model has been implemented in the part-time TU088 Higher Diploma in Medical Science programme to support students who work as hospital laboratory aides. This flexible approach reduces on-site attendance requirements while maintaining academic standards. TU088 runs concurrently with two full-time programs - TU867 BSc in Medical Science and TU888 HDip in Medical Science—and shares key modules delivered in HyFlex mode in stage 2 and stage 4. Additionally, HyFlex is employed in a final-year research module co-taught across TU867, TU866 BSc in Biomedical and Molecular Diagnostics, and TU886 BSc in Biomolecular Science. This supports students completing research projects …


Supporting The Mental Health Of Adolescent Mothers In Kenya And Mozambique: Pilot Protocol For The Thriving Mamas Programme, Tatiana Taylor Salisbury, Maria Suzana Bata Maguele, Fernando Chissale, Málica De Melo, Margrette Hanselmann, Kethakie Lamahewa, Evaline Chepchirchir Langat, Flávio Mandlate, Lucy Nyaga, Marleen Temmerman Jun 2025

Supporting The Mental Health Of Adolescent Mothers In Kenya And Mozambique: Pilot Protocol For The Thriving Mamas Programme, Tatiana Taylor Salisbury, Maria Suzana Bata Maguele, Fernando Chissale, Málica De Melo, Margrette Hanselmann, Kethakie Lamahewa, Evaline Chepchirchir Langat, Flávio Mandlate, Lucy Nyaga, Marleen Temmerman

Centre of Excellence in Women and Child Health

Background: Poor mental health among adolescent girls during pregnancy and the year after birth (the perinatal period) has been found to have a significant detrimental effect on girls and their children. The Innovative approaches to adolescent perinatal wellbeing (INSPIRE) project co-designed an intervention (Thriving Mamas) to improve adolescent perinatal mental health in Kenya and Mozambique. The aim of the current study is to pilot test the co-designed intervention to understand how it can be adapted for further testing or scale-up.

Methods :A mixed-method, pilot cluster-randomised, efectiveness-implementation Hybrid Type II trial will be conducted among 80 adolescent girls (aged 15–19 years) …


Do-It-Yourself Flavored Capsule Cigarettes: Exploiting Potential Regulatory Loopholes?, Page Daniel Dobbs, Eric K. Soule, Margaret Mahoney Jd, Mufazzela Tabassum, Nia Burgess, Lisa Henricksen Jun 2025

Do-It-Yourself Flavored Capsule Cigarettes: Exploiting Potential Regulatory Loopholes?, Page Daniel Dobbs, Eric K. Soule, Margaret Mahoney Jd, Mufazzela Tabassum, Nia Burgess, Lisa Henricksen

Health, Human Performance and Recreation Faculty Publications and Presentations

Introduction

Capsule cigarettes allow users to crush liquid-filled capsules to release flavors into cigarettes’ filters. New devices are emerging across the globe that allow people who smoke to circumvent tobacco flavor restrictions via injectable capsules. This study examined TikTok videos marketing flavored capsule injector devices.

Methods

TikTok videos (n = 832) posted worldwide between July 6, 2021, and December 28, 2023, that used hashtags #injectorflavor, #flavourclickball, #flavorball, and #injectorballcigarette were collected using a TikTok application programing interface. A codebook was developed using a systematic iterative approach, identifying six codes: flavor capsules, promotes flavors (i.e., fruit, mint or menthol flavors, …


Towards Combining Self-Organizing Maps (Som) And Convolutional Neural Network (Cnn) For Improving Model Accuracy: Application To Malaria Vectors Phenotypic Resistance, Komi Mensah Agboka, Elfatih M. Abdel-Rahman, Daisy Salifu, Brian Kanji, Frank T. Ndjomatchoua, Ritter A.Y. Guimapi, Sunday Ekesi, Landmann Tobias Jun 2025

Towards Combining Self-Organizing Maps (Som) And Convolutional Neural Network (Cnn) For Improving Model Accuracy: Application To Malaria Vectors Phenotypic Resistance, Komi Mensah Agboka, Elfatih M. Abdel-Rahman, Daisy Salifu, Brian Kanji, Frank T. Ndjomatchoua, Ritter A.Y. Guimapi, Sunday Ekesi, Landmann Tobias

All Peer-Reviewed Publications

This study introduces a hybrid approach that combines unsupervised self-organizing maps (SOM) with a supervised convolutional neural network (CNN) to enhance model accuracy in vector-borne disease modeling. We applied this method to predict insecticide resistance (IR) status in key malaria vectors across Africa. Our results show that the combined SOM/CNN approach is more robust than a standalone CNN model, achieving higher overall accuracy and Kappa scores among others. This confirms the potential of the SOM/CNN hybrid as an effective and reliable tool for improving model accuracy in public health applications. • The hybrid model, combining SOM and CNN, was implemented …


Intersecting Inequities: Latinx Access To Mental Health Services, Melissa Thorson Jun 2025

Intersecting Inequities: Latinx Access To Mental Health Services, Melissa Thorson

Dissertations

This study examined barriers to mental health service utilization among Latinx populations using data from the 2022 National Survey on Drug Use and Health (NSDUH). Through the theoretical frameworks of Minority Stress Theory and Toxic Stress Theory, the study investigated the relationships between age, language proficiency, socioeconomic status, and mental health service access among different Latinx subgroups. Statistical analyses included chi-square tests, multiple regression, and mediation analyses on a sample of Latinx adults (N = 9,852). Results indicated associations between age and English proficiency (χ² = 145.23, p < .001, Cramer's V = 0.38), with 45% of adults aged 50 and older reporting limited English proficiency. Socioeconomic analysis revealed that 32% of older Latinx adults reported family incomes below $20,000, with insurance status partially mediating the relationship between income and service utilization (indirect effect = 0.15, 95% CI [0.08, 0.23]). differences in utilization rates emerged among Latinx subgroups (F(6, 1243) = 8.76, p < .001, η² = 0.12), with Mexican-origin individuals showing higher utilization (10%) compared to Puerto Rican individuals (2-3%). Age and socioeconomic status demonstrated interaction effects (β = 0.18, p < .01), while language proficiency moderated the relationship between age and service utilization (β = 0.24, p < .001). These findings suggest that barriers to mental health service utilization among Latinx populations are complex and interconnected, requiring multilevel interventions that address linguistic, cultural, and socioeconomic factors simultaneously. Implications for healthcare policy and service delivery are discussed, emphasizing the need for culturally responsive and linguistically appropriate mental health services.


Assessment Of Mental Wellbeing Programs In The Construction Industry, Evan James Olszak Jun 2025

Assessment Of Mental Wellbeing Programs In The Construction Industry, Evan James Olszak

Construction Management

Mental health problems are very prevalent within the construction industry, and there is not enough attention put towards the mental wellbeing of employees in the industry. The construction industry is ranked #2 for deaths by suicide, and #1 when mining and extraction are included (CDC, 2021). Previous research has been done to understand the severity of the issue, and some programs have been started to spread awareness and train employees. The issue arises in a lack of analysis of these programs. The programs that are being used are still in their infancy and require a comprehensive review to understand the …


Awareness, Knowledge, And Motivations About Lifespan, Healthspan, And Healthy Longevity Medicine In The General Population: The Healthy Longevity (Helo) Conceptual Framework, Belinda Wang, Anna Szucs, Elena Sandalova, E. J. Horberg, Paul A. O'Keefe, Louis Island, Hans J. Meij, Sonny Rosenthal, Andrea B. Maier Jun 2025

Awareness, Knowledge, And Motivations About Lifespan, Healthspan, And Healthy Longevity Medicine In The General Population: The Healthy Longevity (Helo) Conceptual Framework, Belinda Wang, Anna Szucs, Elena Sandalova, E. J. Horberg, Paul A. O'Keefe, Louis Island, Hans J. Meij, Sonny Rosenthal, Andrea B. Maier

Research Collection College of Integrative Studies

The global population is ageing and the gap between lifespan (total years lived) and healthspan (years lived free of diseases) is increasing. Healthy Longevity Medicine (HLM) is an approach to optimise health and healthspan, and it has substantial public health implications. Despite those implications, the understanding of public perspectives on this field is lacking. The HEalthy LOngevity (HELO) framework was developed through a literature review guided by expert discussions across disciplines to include evidence-based concepts of health-related decision-making, ageing, and HLM. The framework organises concepts into three components. The first two components, awareness and knowledge, explore public perception and understanding …


Cardiovascular And Thromboembolic Events In Children And Adults With Glomerular Disease: Findings From The Cure Glomerulonephropathy (Curegn) Network., Shikha Wadhwani, Sarah A. Mansfield, Abigail R. Smith, Bruce M. Robinson, Eman Abdelghani, Amira Al-Uzri, Isa F. Ashoor, Sharon M. Bartosh, Aftab S. Chishti, Salim S. Hayek, Michelle A. Hladunewich, Bryce A. Kerlin, Siddharth S. Madapoosi, Laura H. Mariani, Amy K. Mottl, Michelle N. Rheault, Michelle M. O'Shaughnessy, Christopher John Sperati, Tarak Srivastava, David T. Selewski, Chia-Shi Wang, Craig S. Wong, Donald J. Weaver, Myda Khalid, Glomerulonephropathy (Curegn) Study Consortium Jun 2025

Cardiovascular And Thromboembolic Events In Children And Adults With Glomerular Disease: Findings From The Cure Glomerulonephropathy (Curegn) Network., Shikha Wadhwani, Sarah A. Mansfield, Abigail R. Smith, Bruce M. Robinson, Eman Abdelghani, Amira Al-Uzri, Isa F. Ashoor, Sharon M. Bartosh, Aftab S. Chishti, Salim S. Hayek, Michelle A. Hladunewich, Bryce A. Kerlin, Siddharth S. Madapoosi, Laura H. Mariani, Amy K. Mottl, Michelle N. Rheault, Michelle M. O'Shaughnessy, Christopher John Sperati, Tarak Srivastava, David T. Selewski, Chia-Shi Wang, Craig S. Wong, Donald J. Weaver, Myda Khalid, Glomerulonephropathy (Curegn) Study Consortium

Manuscripts, Articles, Book Chapters and Other Papers

RATIONALE & OBJECTIVE: Cardiovascular (CV) and thromboembolic (TE) events are known complications of glomerular disease (GD), but their incidence and risk factors are poorly characterized. This analysis describes CV and TE outcomes in the Cure GlomeruloNephropathy (CureGN) Network.

STUDY DESIGN: Prospective cohort study.

SETTING & PARTICIPANTS: CureGN is a prospective cohort study of children and adults with biopsy-proven minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN), or IgA nephropathy (IgAN)/vasculitis (IgAV). Data from 2,545 children and adults (23% MCD, 23% MN, 25% FSGS, 29% IgAN/IgAV) was analyzed.

EXPOSURE: Estimated glomerular filtration rate (eGFR), proteinuria, serum albumin, tobacco …


Covid-19 Pandemic Impacts On Behavioral And Emotional Health Of Young Children With Autism., Olivia M. Pokoski, Hayley M. Crain, Sarah M. Furnier, Ronald E. Gangnon, Cy Nadler, Eric J. Moody, Karen Pazol, Maria A. Stanley, Lisa D. Wiggins, Maureen S. Durkin Jun 2025

Covid-19 Pandemic Impacts On Behavioral And Emotional Health Of Young Children With Autism., Olivia M. Pokoski, Hayley M. Crain, Sarah M. Furnier, Ronald E. Gangnon, Cy Nadler, Eric J. Moody, Karen Pazol, Maria A. Stanley, Lisa D. Wiggins, Maureen S. Durkin

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: To test initial hypotheses that the coronavirus disease 2019 (COVID-19) pandemic was associated with decreases in adaptive behavior and increases in behavioral and emotional problems of children with autism; greater impacts for children who lost specialty services; and greater behavioral and emotional problems for children with autism vs control participants.

METHOD: Eligible participants (N = 1,158) enrolled in phase 3 of the multisite, case-control Study to Explore Early Development (SEED) before March 31, 2020, were between 2 and 5 years old, and completed follow-up assessments between January and July 2021. Caregivers completed a COVID-19 Impact Assessment Questionnaire, Vineland Adaptive …


A Rare Sequela Of Untreated Streptococcus Pharyngitis: A Case Report., Meredith Hiltbrand Lehoe, Emily Cushing Jun 2025

A Rare Sequela Of Untreated Streptococcus Pharyngitis: A Case Report., Meredith Hiltbrand Lehoe, Emily Cushing

Ambulatory and Primary Care Articles

Pharyngitis is commonly caused by the gram positive bacteria, streptococcus. Given the potential morbid complications of untreated streptococcal pharyngitis, antibiotics are critical. One of the rarer complications is pulmonary-renal syndrome (PRS), defined as rapidly progressive glomerulonephritis and diffuse alveolar hemorrhage. PRS is associated with high rates of morbidity and mortality, making swift diagnosis and treatment imperative for survival. More common causes of PRS are tied to autoimmune diseases. This case describes a novel progression of PRS caused by streptococcus. A 26-year-old male with no significant medical history presented to our emergency department with streptococcal group A-positive sore throat. After discontinuing …


The Glim Consensus Approach To Diagnosis Of Malnutrition: A 5-Year Update., Tommy Cederholm, Gordon L Jensen, M Isabel T D Correia, M Cristina Gonzalez, Ryoji Fukushima, Veeradej Pisprasert, Renee Blaauw, Diana Cardenas Braz, Fernando Carrasco, Alfonso J Cruz Jentoft, Cristina Cuerda, David C Evans, Vanessa Fuchs-Tarlovsky, Leah Gramlich, Han Ping Shi, Jeanette M Hasse, Michael Hiesmayr, Naoki Hiki, Harriët Jager-Wittenaar, Shukri Jahit, Anayanet Jáquez, Heather Keller, Stanislaw Klek, Ainsley Malone, Kris M Mogensen, Naoharu Mori, Manpreet Mundi, Maurizio Muscaritoli, Doris Ng, Ibolya Nyulasi, Matthias Pirlich, Stephane Schneider, Marian De Van Der Schueren, Soranit Siltharm, Pierre Singer, Alison Steiber, Kelly A Tappenden, Jianchun Yu, André Van Gossum, Jaw-Yuan Wang, Marion F Winkler, Rocco Barazzoni, Charlene Compher Jun 2025

The Glim Consensus Approach To Diagnosis Of Malnutrition: A 5-Year Update., Tommy Cederholm, Gordon L Jensen, M Isabel T D Correia, M Cristina Gonzalez, Ryoji Fukushima, Veeradej Pisprasert, Renee Blaauw, Diana Cardenas Braz, Fernando Carrasco, Alfonso J Cruz Jentoft, Cristina Cuerda, David C Evans, Vanessa Fuchs-Tarlovsky, Leah Gramlich, Han Ping Shi, Jeanette M Hasse, Michael Hiesmayr, Naoki Hiki, Harriët Jager-Wittenaar, Shukri Jahit, Anayanet Jáquez, Heather Keller, Stanislaw Klek, Ainsley Malone, Kris M Mogensen, Naoharu Mori, Manpreet Mundi, Maurizio Muscaritoli, Doris Ng, Ibolya Nyulasi, Matthias Pirlich, Stephane Schneider, Marian De Van Der Schueren, Soranit Siltharm, Pierre Singer, Alison Steiber, Kelly A Tappenden, Jianchun Yu, André Van Gossum, Jaw-Yuan Wang, Marion F Winkler, Rocco Barazzoni, Charlene Compher

Ambulatory and Primary Care Articles

BACKGROUND: The Global Leadership Initiative on Malnutrition (GLIM) introduced an approach for malnutrition diagnosis in 2019 comprised of screening followed by assessment of three phenotypic criteria: weight loss, low BMI, and low muscle mass, and two etiologic criteria: reduced food intake/assimilation, and inflammation/disease burden. This planned update reconsiders the GLIM framework based on published knowledge and experience over the past five years.

METHODS: A GLIM working group (n = 43 members) conducted a literature search spanning 2019-2024 using the keywords "Global Leadership Initiative on Malnutrition or GLIM". Prior GLIM activities providing guidance for use of the criteria on muscle mass …


Enhanced Hair Regrowth With Five Monthly Sessions Of Minoxidil-Dutasteride-Copper Peptides Tattooing For Androgenetic Alopecia Assessed By Artificial Intelligence And Blinded Evaluators., Guilherme Kuceki, Austin J Coppinger, Sara D Ragi, Luke S Johnson, Andy Goren, Luiza L Kalil, Pablo Cirino, Carlos G Wambier Jun 2025

Enhanced Hair Regrowth With Five Monthly Sessions Of Minoxidil-Dutasteride-Copper Peptides Tattooing For Androgenetic Alopecia Assessed By Artificial Intelligence And Blinded Evaluators., Guilherme Kuceki, Austin J Coppinger, Sara D Ragi, Luke S Johnson, Andy Goren, Luiza L Kalil, Pablo Cirino, Carlos G Wambier

Ambulatory and Primary Care Articles

No abstract provided.


Exploring Teacher Behaviors That Support Student Self-Regulated Learning In The Clinical Environment, Stephanie B Corliss, Emily K Vinas, Andrew D Bergemann, Jonathan A Macclements, Elizabeth A Nelson Jun 2025

Exploring Teacher Behaviors That Support Student Self-Regulated Learning In The Clinical Environment, Stephanie B Corliss, Emily K Vinas, Andrew D Bergemann, Jonathan A Macclements, Elizabeth A Nelson

Faculty and Staff Publications

Introduction: With rapidly evolving clinical practice and medical knowledge, future doctors must be independent lifelong learners. Self-regulated learning (SRL) represents a formalized approach to lifelong learning, involving cycles of planning, learning, assessment, and adjustment. Medical schools can create clinical environments where learners are instructed in SRL and encouraged to routinely practice using it. Clinical educators can provide guidance in SRL by co-regulating learning with students. The purpose of this study is to explore how clinical teachers co-regulate the learning process with students during clinical clerkships.

Methods: Data was analyzed from student evaluations of clinical teaching faculty and residents during clinical …


In Vitro Evaluation Of A Novel Computationally Designed Anticancer Peptide In Ovarian Cancer Cell Models, Basma A. Shaala Jun 2025

In Vitro Evaluation Of A Novel Computationally Designed Anticancer Peptide In Ovarian Cancer Cell Models, Basma A. Shaala

Theses and Dissertations

Ovarian cancer remains one of the leading causes of cancer-related mortality among

women, highlighting the need for novel therapeutic agents with improved selectivity and

reduced toxicity. Anticancer peptides (ACPs) have emerged as promising candidates

due to their ability to selectively target cancer cells. In this study, the anticancer activity

of a computationally designed ACP was evaluated in vitro using the SKOV-3 ovarian

cancer cell line, with HEK cells employed as a non-cancerous control.

Cell viability was assessed using the MTT assay, and cytotoxicity was further confirmed

by the trypan blue exclusion method. Apoptosis and necrosis were analyzed using

Annexin V-FITC/Propidium …


Epidemiology Of Shigella Species And Serotypes In Children: A Retrospective Substudy Of The Mal-Ed Observational Birth Cohort Study, Elizabeth T. Rogawski Mcquade, Jie Liu, Mustafa Mahfuz, Alexandre Havt, Furqan Kabir, Adil Kalam, Fatima Aziz, Sahrish Muneer, Najeeha Talat Iqbal, Zulfiqar Ahmed Bhutta Jun 2025

Epidemiology Of Shigella Species And Serotypes In Children: A Retrospective Substudy Of The Mal-Ed Observational Birth Cohort Study, Elizabeth T. Rogawski Mcquade, Jie Liu, Mustafa Mahfuz, Alexandre Havt, Furqan Kabir, Adil Kalam, Fatima Aziz, Sahrish Muneer, Najeeha Talat Iqbal, Zulfiqar Ahmed Bhutta

Department of Paediatrics and Child Health

Background: Shigellosis is a leading cause of diarrhoea in children globally. We aimed to assess the burden of specific Shigella species and Shigella flexneri serotypes, characterise their clinical syndromes and natural immunity, and evaluate their relevance as causes of diarrhoea and linear growth faltering.
Methods: In the MAL-ED birth cohort study, children younger than 17 days were enrolled from Nov 3, 2009, to Feb 29, 2012, in Bangladesh, Brazil, India, Nepal, Pakistan, Peru, Tanzania, and South Africa and were followed up for 2 years. In this retrospective substudy, we retested Shigella quantitative PCR-positive diarrhoeal and non-diarrhoeal stool samples with molecular …


Extracellular Matrix Repair And Organization Of Chronic Infected Diabetic Wounds Treated With Methacrylated Chitosan-Based Hydrogels, Nic D. Leipzig, Shahrzad Abri, Hannah A. Durr, Samuel D. Salinas Jun 2025

Extracellular Matrix Repair And Organization Of Chronic Infected Diabetic Wounds Treated With Methacrylated Chitosan-Based Hydrogels, Nic D. Leipzig, Shahrzad Abri, Hannah A. Durr, Samuel D. Salinas

University Research

Diabetic foot ulcers (DFUs) are a multifactorial medical problem that require multifaceted approaches for effective healing. Most research on DFU healing has concentrated on promoting wound closure, with less emphasis on the quality of repaired tissue. This is problematic, however, since quality of the repaired tissues can have potential to improve wound healing outcomes and limit re-ulceration. If more functionally active dermis replaces the lost tissue, this can effectively maximize strength, organization, and overall structure of the plantar surface. Additionally, DFUs commonly show multi-strain infection, which further exacerbates the non-healing status of these wounds. Treatment of chronic wounds can be …


Intersectoral Interventions: Integration For Impact On Preterm Birth, Etienne V. Langlois, Maria El Bizri, Kelly Thompson, Amy Reid, Merette Khalil, Giulia Gasparri, Joy E. Lawn, Teesta Dey, Judith Robb-Mccord, Marleen Temmerman Jun 2025

Intersectoral Interventions: Integration For Impact On Preterm Birth, Etienne V. Langlois, Maria El Bizri, Kelly Thompson, Amy Reid, Merette Khalil, Giulia Gasparri, Joy E. Lawn, Teesta Dey, Judith Robb-Mccord, Marleen Temmerman

Centre of Excellence in Women and Child Health

Progress: The last two decades have seen a growing focus on intersectoral interventions to improve maternal and newborn health and well-being outcomes, as refected in eforts to achieve the Millennium Development Goals (MDGs) and advance the Sustainable Development Goals (SDGs). Preterm births are linked to cross-sectoral determi‑ nants that afect health outcomes and human capital across the life-course, necessitating an intersectoral approach that addresses these multifaceted challenges.

Programmatic priorities: Recognizing that social, biological and economic determinants signifcantly infuence health outcomes, it is critical that robust health systems are reinforced by a comprehensive intersectoral approach. Evidence suggests that the factors infuencing …


The Impact Of Implementing The Women's Reproductive Rights Agenda On Climate Change, Marleen Temmerman, Emilie Peeters, Celine Delacroix, Malachi Arunda, Sara Khalid, Claudia Hanson, Samuel Ojong Jun 2025

The Impact Of Implementing The Women's Reproductive Rights Agenda On Climate Change, Marleen Temmerman, Emilie Peeters, Celine Delacroix, Malachi Arunda, Sara Khalid, Claudia Hanson, Samuel Ojong

Centre of Excellence in Women and Child Health

The 1994 International Conference on Population and Development (ICPD) established sexual and reproductive health and rights (SRHR) as foundational to sustainable development. Thirty years later, advancing women's reproductive rights (WRR), encompassing agency, decision-making autonomy, and universal access to family planning—remains critical not only for health and gender equity but also for mitigating environmental degradation. By reducing unintended pregnancies and empowering women to align childbearing with personal and ecological capacity, WRR alleviates ecological stressors such as deforestation while enhancing health resilience in climate-vulnerable communities. Yet, despite well-documented linkages between population dynamics and environmental change, contemporary climate policies and funding mechanisms persistently …


Dean's Update, June 2025, Neil W. Schluger Jun 2025

Dean's Update, June 2025, Neil W. Schluger

SOM Dean's Research Newsletter

No abstract provided.


Factors Associated With Perceived Medication Safety During Transitions Of Care In Patients With Cancer: A Secondary Data Analysis Of A Cross-Sectional Survey, Youmin Cho, Misun Hwang, Yang Gong, Yun Jiang Jun 2025

Factors Associated With Perceived Medication Safety During Transitions Of Care In Patients With Cancer: A Secondary Data Analysis Of A Cross-Sectional Survey, Youmin Cho, Misun Hwang, Yang Gong, Yun Jiang

Faculty, Staff and Student Publications

Purpose: This study aimed to investigate perceived medication safety in patients with cancer during transitions of care and identify factors associated with their safety perceptions.

Methods: A secondary data analysis was performed on a cross-sectional survey data of from patients with four types of cancer (i.e., colorectal, lung, prostate, and breast). Perceived medication safety was measured by the sum score of four survey items that assessed patients' feelings about medication safety during transitions of care. Potential associated factors included sociodemographic and clinical factors (i.e., cancer types, taking oral anticancer agents), self-rated health, perceived safety in communicating with clinicians, beliefs about …


Computerized Diagnostic Decision Support Systems-Isabel Pro Versus Chatgpt-4 Part Ii, Joe M Bridges, Xiaoqian Jiang, Michael Ige, Oluwatoniloba Toyobo Jun 2025

Computerized Diagnostic Decision Support Systems-Isabel Pro Versus Chatgpt-4 Part Ii, Joe M Bridges, Xiaoqian Jiang, Michael Ige, Oluwatoniloba Toyobo

Faculty, Staff and Student Publications

Objective: Does a Tree-of-Thought prompt and reconsideration of Isabel Pro's differential improve ChatGPT-4's accuracy; does increasing expert panel size improve ChatGPT-4's accuracy; does ChatGPT-4 produce consistent outputs in sequential requests; what is the frequency of fabricated references?

Materials and methods: Isabel Pro, a computerized diagnostic decision support system, and ChatGPT-4, a large language model. Using 201 cases from the New England Journal of Medicine, each system produced a differential diagnosis ranked by likelihood. Statistics were Mean Reciprocal Rank, Recall at Rank, Average Rank, Number of Correct Diagnoses, and Rank Improvement. For reproducibility, the study compared the initial expert panel run …


Perception, Usage, And Concerns Of Artificial Intelligence Applications Among Postgraduate Dental Students Cross-Sectional Study, Dalia Ghalwash, Asmaa Abou-Bakr, Susan Sarhan, Amira Badra, Hadeel Almalahy Jun 2025

Perception, Usage, And Concerns Of Artificial Intelligence Applications Among Postgraduate Dental Students Cross-Sectional Study, Dalia Ghalwash, Asmaa Abou-Bakr, Susan Sarhan, Amira Badra, Hadeel Almalahy

Dentistry

Background

Future dental applications of artificial intelligence (AI) are anticipated to be widely adopted across all dental specialities. However, there are some concerns among many users about the accuracy of the given information. Therefore, this study aimed to investigate postgraduate’ dental students’ perception, usage, and concerns towards AI systems’ applications.

Materials and methods

An online self-administered survey, consisting of 19 closed-ended questions in the English language, and a 3-point Likert-type scale was used to obtain a simple and straightforward response from participants in a “forced-choice” response format that was distributed to postgraduate dental students in the faculty of dentistry of …


Encoding 3d Information In 2d Feature Maps For Brain Ct-Angiography, Uma M Lal-Trehan Estrada, Sunil Sheth, Arnau Oliver, Xavier Lladó, Luca Giancardo Jun 2025

Encoding 3d Information In 2d Feature Maps For Brain Ct-Angiography, Uma M Lal-Trehan Estrada, Sunil Sheth, Arnau Oliver, Xavier Lladó, Luca Giancardo

Faculty, Staff and Student Publications

We propose learnable 3D pooling (L3P), a CNN module designed to compress 3D information into 2D feature maps using anisotropic convolutions and unidirectional max pooling. Specifically, we used L3P followed by a 2D network to generate predictions from 3D brain CT-Angiography (CTA) in the context of large vessel occlusion (LVO). To further demonstrate its versatility, we extended its application to 3D brain MRI analysis for brain age prediction. First, we designed an experiment to classify the LVO-affected hemisphere (left or right), projecting the input CTA into the sagittal plane, which allowed to assess the ability of L3P to encode the …


Building Community Through Data: The Value Of A Researcher Driven Open Science Ecosystem, Meredith C B Adams, Carla M Bann, Emine Ozgur Bayman, Maria Chao, Georgene W Hergenroeder, Charles Knott, Martin A Lindquist, Z David Luo, Rosemarie Martin, Maryann E Martone, John Mccarthy, Micah Mccumber, Sharon B Meropol, Ty A Ridenour, Lissette M Saavedra, Abeed Sarker, Kevin J Anstrom, Wesley K Thompson Jun 2025

Building Community Through Data: The Value Of A Researcher Driven Open Science Ecosystem, Meredith C B Adams, Carla M Bann, Emine Ozgur Bayman, Maria Chao, Georgene W Hergenroeder, Charles Knott, Martin A Lindquist, Z David Luo, Rosemarie Martin, Maryann E Martone, John Mccarthy, Micah Mccumber, Sharon B Meropol, Ty A Ridenour, Lissette M Saavedra, Abeed Sarker, Kevin J Anstrom, Wesley K Thompson

Faculty, Staff and Student Publications

No abstract provided.