Medicine and Health Sciences Commons^™

Synergistic Potential Of Sipuleucel-T In Enhancing Immunotherapy For Metastatic Castration-Resistant Prostate Cancer, Kavita Rawat, Varnika Punia, Parker Mathews, Sara Mccoy, Wilbur Song, Muhammad A Saeed, Russell K Pachynski

2020-Current year OA Pubs

Clinical trials of immunotherapy in metastatic castration-resistant prostate cancer (mCRPC) have largely been unsuccessful despite promising preclinical studies and proven efficacy in other solid tumors. These disappointing clinical outcomes have been attributed to an immunosuppressive tumor microenvironment, a relative lack of infiltrating immune effector cells, and tumor-related and host-related factors, which collectively render prostate cancer a relatively immunologically "cold" tumor. Sipuleucel-T (Provenge), an autologous cellular immunotherapy, induces an immune response targeted against prostatic acid phosphatase. It received approval from the US Food and Drug Administration in 2010, marking the first immunotherapy to show an overall survival benefit in patients with …

Patient-Centered Televisit For Chronic Obstructive Pulmonary Disease Discharge Transitions: User-Centered Design Study, Joanna Abraham, Alicia Meng, Nicolas Caravelli, Leah Traeger, May Nguyen, Vineet Arora, Valerie G Press

2020-Current year OA Pubs

BACKGROUND: Chronic obstructive pulmonary disease (COPD) affects approximately 16 million Americans and often results in avoidable readmissions due, in part, to medication errors and lack of education. Telehealth interventions can support medication reconciliation and inhaler education following hospital discharge for patients with COPD.

OBJECTIVE: This study aimed to design and prototype TELE-TOC (Telehealth Education: Leveraging Electronic Transitions of Care), a post-discharge, in-home, televisit intervention, and to map its workflow to ensure integration into the routine discharge care transition process for patients with COPD.

METHODS: A user-centered design approach across 3 phases was followed to develop and prototype TELE-TOC. Participants included …

Increased Intermembrane Space [Ca2+] Drives Mitochondrial Structural Damage In Cpvt, Shanna Hamilton, Radmila Terentyeva, Roland Veress, Fruzsina Perger, Zuzana Nichtova, Mark Bannister, Jinxi Wang, Sage Quiggle, Rachel Battershell, Matthew Gorr, Sandor Györke, Bum-Rak Choi, Christopher George, Andriy Belevych, György Csordás, Dmitry Terentyev

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Mitochondrial dysfunction caused by abnormally high RyR2 (ryanodine receptor) activity is a common finding in cardiovascular diseases. Mechanisms linking RyR2 gain of function with mitochondrial remodeling remain elusive. We hypothesized that RyR2 hyperactivity in cardiac disease increases [Ca 2+ ] in the mitochondrial intermembrane space (IMS) and activates the Ca 2+ -sensitive protease calpain, driving remodeling of mitochondrial cristae architecture through cleavage of structural protein OPA1 (optic atrophy protein 1).

METHODS: We generated a highly arrhythmogenic rat model of catecholaminergic polymorphic ventricular tachycardia, induced by RyR2 gain-of-function mutation S2236L(Ser2336Leu)(+/-) . We created a new biosensor to measure IMS-[Ca2+ ] …

Radiation-Induced Brachial Plexopathy: Current Understanding, Diagnosis, And Treatment Options, Alex G. Lambi, Tomas Holly, Ryan E. Tomlinson, Mary F. Barbe

Department of Orthopaedic Surgery Faculty Papers

Radiation-induced brachial plexopathy (RIBP) is a gruesome complication of cancers treated with radiation therapy around the lung and chest wall, head and neck, and breast and axilla. It can occur in an early-onset (transient) or a late-onset (chronic) fashion. The diagnosis involves exclusion of a compressive neoplastic process, either new or recurrent, and relies largely on patient symptomatology without well-validated, objective scoring systems. Treatment options remain limited as no major advances have been made to prevent or halt disease progression. This article reviews the background incidence, pathophysiology, and diagnosis of RIBP. In addition to surgical treatment options, nonsurgical modalities, often …

Protein-Protein Interaction–Interfering Peptide Rescues Dysregulated Nmda Receptor Signaling, Robert E. Featherstone, Hongbin Li, Ameet S. Sengar, Karin E. Borgmann-Winter, Olya Melnychenko, Lindsey M. Crown, Ray L. Gifford, Felix Amirfathi, Anamika Banerjee, Aivi Tran, Krishna Parekh, Margaret Heller, Wenyu Zhang, Robert J. Gallop, Adam D. Marc, Pragya Komal, Michael W. Salter, Steven J. Siegel, Chang-Gyu Hahn

Farber Institute for Neuroscience Faculty Papers

The complex and heterogeneous genetic architecture of neuropsychiatric illnesses compels us to look beyond individual risk genes for therapeutic strategies and target the interactive dynamics and convergence of their protein products. A mechanistic substrate for convergence of synaptic neuropsychiatric risk genes are protein-protein interactions (PPIs) in the N-methyl-D-aspartate receptor (NMDAR) complex. NMDAR hypofunction in schizophrenia is associated with hypoactivity of Src kinase, resulting from convergent alterations in PPIs of Src with its partners. Of these, the association of Src with PSD-95, which inhibits the activity of this kinase in the NMDAR complex, is known to be increased in schizophrenia. Here, …

G6pd Deficiency, Annette C. Osias Arredondo

Honors Capstones

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked recessive enzyme disorder affecting over 400 million people worldwide.G6PD is essential for producing NADPH, which maintains reduced glutathione (GSH)—the RBC’s primary defense against oxidative damage. When G6PD activity is low, RBCs cannot neutralize oxidants, leading to hemoglobin oxidation, Heinz body formation, and subsequent bite cells and hemolysis. Symptoms range from asymptomatic to acute hemolytic crises, especially after exposure to oxidative triggers such as infections, certain drugs, or fava beans.

A Quality Improvement Project: Faculty Education On Diversity, Equity, And Inclusion Principles, Ashley Mcdoulett

Doctor of Nursing Practice Projects

According to the literature, social injustices, inequities, and implicit bias influence health outcomes in marginalized populations. To eliminate health disparities, nurses should be prepared to provide care that addresses these issues, and faculty should be able to effectively integrate diversity, equity, and inclusion (DEI) principles into the nursing curriculum. A literature review suggests the integration of DEI into nursing education is lacking, and by offering an educational session for faculty on best practices for curriculum incorporation, this project aimed to address that gap. The Reach, Effectiveness, Adoption, Implementation, Maintenance (RE-AIM) model guided this project. RE-AIM emphasizes targeting a population to …

Asian College Students' Well-Being During A Period Of Rising Anti-Asian Sentiment, Kyuhan Choi, Ying Shi, Maria Zhu

Center for Policy Research

We use a large survey of students in U.S. colleges to study the distinct ways in which the COVID-19 pandemic and accompanying anti-Asian rhetoric shaped the experiences of Asian and Pacific Islanders (APIs). Using a difference-in-differences approach, we find that the pandemic led to Asian students experiencing more discrimination, feeling less safe during the day, and using fewer mental health services compared to White peers. The increase in discrimination and the perceived lower safety are concentrated among East and Southeast Asians, while South Asians were not affected. Despite these effects, we detect no relative deterioration in severe psychological distress or …

Comprehensive Analysis Platform To Understand, Remedy, And Eliminate Amyotrophic Lateral Sclerosis (Capture Als): Study Protocol For A Canadian Multicenter, Multimodal, Longitudinal Observational Study, Natalie Saunders, Claire Magnussen, Hyungmo Kang, Mathieu Blais, Harpreet Bhinder, Gerald Pfeffer, Shelagh K. Genuis, Liziane Bouvier, Tanushka Anand, Tania M. Bubela

Office of the Provost

Background: The marked heterogeneity of Amyotrophic Lateral Sclerosis (ALS) combined with a lack of biomarkers are key contributing factors to the lack of disease-modifying treatments. The Comprehensive Analysis Platform to Understand Remedy and Eliminate ALS (CAPTURE ALS) is a Canadian platform designed to create the most comprehensive picture of people living with ALS with the objective of facilitating ALS research initiatives worldwide.
Objectives: The main aims of CAPTURE ALS include: (1) to characterize ALS and healthy controls with biosamples and data in order to provide the most comprehensive picture of individuals living with ALS to date; (2) to create a …

Universal School Meal Policies And Perceived Stigma: Quantitative Evidence From Eight Us States, Dania Orta-Aleman, Monica D. Zuercher, Leah Chapman, Marlene B. Schwartz, Caitlin D. French, Anisha I. Patel, Lorrene D. Ritchie, Juliana Cohen, Wendi Gosliner

Health Sciences Faculty Publications

Background

Universal school meals (USMs) policies, which provide free meals to all students regardless of income, have the potential to improve child nutrition and reduce stigma. Quantitative evidence on the association between USM and stigma is limited.

Methods

Leveraging a natural policy variation in state‐level USM implementation, we surveyed 1066 middle and high school students from eight US states (four with USM, four without) during the 2022–2023 school year. Stigma was measured as self‐reported embarrassment about eating school lunch. We used generalized estimating equations to examine the associations between USM, embarrassment, and lunch participation.

Results

Overall about one in nine …

Changing Trends In Paediatric Acute Respiratory Infections: Pre- And Post-Covid-19 Presenting To An Emergency Department In An Academic Tertiary Hospital In Oman, Awatif K Alsarrai Al-Alawi, Aalia Adnan Alwahshi, Darpanarayan Hazra, Usama Al Khalasi, Amal Al-Shibli, Azhaar Al Harrasi, Sumaira Iram

Sultan Qaboos University Medical Journal

Objectives: The COVID-19 pandemic disrupted seasonal paediatric respiratory infections due to widespread non-pharmaceutical interventions, sharply reducing viral circulation. This study aimed to compare paediatric viral acute respiratory infection (ARI) patterns and outcomes pre- and post-COVID-19 using hospital-based data from Oman. Methods: This retrospective cross-sectional study was conducted at the Paediatric Emergency Department, Sultan Qaboos University Hospital in Muscat, Oman. Paediatric patients who underwent PCR testing for respiratory viruses before (December 1, 2018 to December 31, 2019) and after (April 1, 2022 to April 30, 2023) the pandemic. Quantitative data is presented as means ± standard deviations and qualitative data as …

Associations Between County-Level E-Cigarette-Inclusive Tobacco 21 Law Population Coverage And E-Cigarette Use Behaviors Among United States Adolescents In Monitoring The Future, James H. Buszkiewicz, Catherine A. Vander Woude, Yanmei Xie, Steven Cook, Bukola Usidame, Megan E. Patrick, Michael R. Elliott, James F. Thrasher, Nancy L. Fleischer

Department of Health and Kinesiology Faculty Publications

Background and aims

In the United States (US), Tobacco 21 (T21) laws set the minimum legal sale age for all tobacco products to 21 years. This study aimed to examine whether e-cigarette-inclusive T21 laws were associated with e-cigarette use behaviors and related disparities among US adolescents.

Design

We used nationally representative, repeated cross-sectional Monitoring the Future data to compare self-reported current e-cigarette use (2014–2022) and first e-cigarette initiation (2015–2022) among adolescents in counties with 100% ('full') versus < 100% ('partial or no') e-cigarette-inclusive T21 law population coverage using modified Poisson regression, examining differences by sex, race and ethnicity, parental educational attainment and college educational expectations through interactions.

Setting

United States.

Participants

8th, 10th and 12th graders.

Measurements

County-level e-cigarette-inclusive T21 law population coverage was determined using Tobacco 21 Population Coverage …

Prevalence And Factors Associated With Alcohol And Illicit Drug Use Among Brazilian Youth: A Multicenter Cross-Sectional Study, Emerson Brito, Marina Bessel, Natalia Luiza Kops, Lucas Albrechet-Souza, Flavia Moreno, Alexis Koskan, Thayane Martins Dornelles, Ben Hur Graboski Pinheiro, Suelen Basgalupp, Eliana Wendland

School of Medicine Faculty Publications

This study examined alcohol and illicit drug use among Brazilian youth aged 16 to 25 during the transition to adulthood. A multicenter, cross-sectional survey was conducted between Sep-2016 and Dec-2017 across all 26 Brazilian state capitals and the Federal District. A total of 8,581 participants completed structured interviews on substance use and sociodemographic characteristics. Lifetime prevalence was 71.6% for alcohol and 30% for illicit drugs. Frequent alcohol use was more common among males, while the most used illicit substances were cannabis (27.4%) and cocaine (9.9%). Participants without a partner had higher rates of alcohol and hallucinogen use, while those with …

Laboratory Monitoring In Patients With Moderate To Severe Plaque Psoriasis, Jonathan M. Fenkel, John A. Osborne, April W. Armstrong, Bruce Strober, Linda Stein Gold, Michael Cameron, Mark Lebwohl

Department of Medicine Faculty Papers

OBJECTIVES: Plaque psoriasis is a common immune-mediated disease associated with various comorbidities, including cardiovascular disease, diabetes, psoriatic arthritis, liver disease, and mood disorders. Biologic and small-molecule therapies are efficacious and well tolerated in adults with moderate to severe plaque psoriasis. However, dermatologists may be uncertain about appropriate laboratory monitoring in patients treated with these therapies, especially those with comorbidities.

METHODS: This review summarizes prescribing information and provides expert recommendations based on real-world experience in the monitoring of concerning laboratory values in patients with psoriasis.

RESULTS: Individualized monitoring is essential for maximizing the benefits and minimizing the risks associated with biologic …

The Differential Effects Of Fast Walking Speed On Muscle Coactivation In The Paretic And Non-Paretic Extremities Post-Stroke, Natalia Sánchez, Andrian Kuch, Samantha N. Jeffcoat, Andrew Hooyman, Aria Haver-Hill, Christina K. Holl, Kristan A. Leech

Physical Therapy Faculty Articles and Research

Background:

Clinical practice guidelines for walking recovery post-stroke recommend high aerobic intensity training, which usually involves walking at fast speeds. However, the acute effect of fast speeds on the neuromuscular control of walking is unclear.

Objectives:

(1) Assess the criterion validity of the Dynamic Motor Control Index (WalkDMC) as a measure of coactivation post-stroke. (2) Assess acute speed-dependent coactivation post-stroke. (3) Assess how clinical characteristics shape the speed-dependent coactivation response. (4) Assess the relationship between heart rate and coactivation post-stroke. We hypothesized that WalkDMC is correlated with function and impairment measures. We also hypothesize that coactivation measured via the WalkDMC …

Primary Care Provider Communication Barriers With College-Aged Students, Mckenna Mahakian, Sharon Schaeffer, Rachel Immel

Honors Projects

As both a researcher and a college student, I’ve noticed that my peers and I share a common negative sentiment toward scheduling and attending routine doctor’s appointments. There are unique barriers in place for the age demographic; college students encountering the medical system and Primary Care Providers (PCPs) seem to have unique challenges in communication. I released a qualitative, anonymous survey to Bowling Green State University students to gauge opinionated responses on sentiments regarding how they felt about the level of communication between themselves and their provider, how the pediatric switch to a regular doctor impacted their inpatient care, how …

Methylene Blue Associated Retinal Toxicity, Sidra Zafar, Martin Calotti, Timothy T. Xu, Justin Muste, Theodore Bowe, Luis Acaba-Berrocal, Brian Cheng, Samir Patel, Yoshihiro Yonekawa, Jose S. Pulido, Jordan D. Deaner

Wills Eye Hospital Papers

BACKGROUND: To describe a case of inadvertent methylene blue use during pars plana vitrectomy (PPV) for an epiretinal membrane (ERM).

CASE: A 69-year-old man presented with 1 day of severe vision loss in his left eye. Two days prior to presentation, he had undergone PPV that was complicated by accidental methylene blue use. Visual acuity (VA) at presentation to our institution was CF from his baseline VA of 20/60. Optical coherence tomography (OCT) demonstrated diffuse hyperreflectivity and thickening of the inner retinal layers. The patient was started on oral prednisone with no improvement. On postoperative month 1, VA was HM. …

Clinical Practice Guideline On Reducing Catheter -Associated Urinary Tract Infections (Cautis), Nkechi Christiana Udah

Walden Dissertations and Doctoral Studies

The project was a clinical practice guideline (CPG) for early catheter removal to prevent catheter-associated urinary tract infections (CAUTIs). At the project site, the practice gap was the surgical nurses’ nonadherence to clinical guidelines for reducing CAUTIs. This gap resulted in inconsistent catheter care practices and delays in catheter removal. The purpose of this CPG was to enhance surgical nurses’ knowledge and adherence to clinical guidelines for reducing CAUTI rates. The following practice-focused question guided the project: In hospitalized patients in acute care settings, does early removal of the urinary catheter compared to leaving the catheter until discharge reduce the …

Staff Education For Enhancing Providers’ Knowledge Of Long Acting Injectables (Lais) Antipsychotics In The Outpatient Mental Health Clinic, Belinda Okoruwa

Walden Dissertations and Doctoral Studies

This doctoral study is a quality-improvement educational program in an outpatient mental health clinic designed to address the underutilization of long-acting injectable (LAI) antipsychotics due to gaps in providers’ knowledge. The project question centered on whether structured education on LAIs antipsychotics increases providers’ knowledge in an outpatient mental health setting. The purpose of this project is to increase LAI antipsychotic utilization by educating providers about the advantages, safety, and appropriate administration to promote consistent implementation. In this project, I used a single-group pre/post design including six participants, incorporating a 12-item questionnaire and 5-point Likert scale questions (Not at all/Somewhat/Very Much). …

The Effect Of Community-Based Exercise For Individuals With Pre-Existing Health Conditions, Amy M. Stahl

Doctoral Dissertations and Projects

Physical inactivity is a growing problem for the health and wellbeing of the world’s population. Increases in physical activity may help to improve health outcomes for the general population of the United States. This study is two-fold and seeks to determine if community-based exercise groups are successful in improving the health of people with preexisting conditions and encouraging community members to adhere to an exercise program. A quasi-experimental 12-week comparison study consists of a control group of standard care and an intervention group that participates in a three-day a week community walking group. The purpose of the group is to …

Examining Social Determinants Of Health And The Impact On Hiv Outcomes In Black People In The United States, Triscia G. Martin

Doctoral Dissertations and Projects

Black people are disproportionately affected by HIV as evidenced by poor clinical outcomes and mortality. Clinical outcomes may be potentiated by patient factors, compounded by social determinants of health. This cross-sectional study sought to examine the impact of social determinants of health on AIDS mortality in the United States. Deidentified HIV data from the CDC NCHHSTP Atlas Plus repository and CDC WONDER population data were utilized to examine the association of race, sex, transmission category and geography on AIDS mortality in 43 states during 2018 to 2022. AIDS mortality was further examined through the lens of HIV stigma and housing …

Do Games Play A Role In Personal Socialization?, Jasmine Reyna Landry

Doctoral Dissertations and Projects

The purpose of this descriptive phenomenological study was to explore how online gamers aged 20 to 40 experience the impact of socialization on self-verification and personal purpose. Semi-structured interviews with eleven participants were conducted, and data were analyzed using Colaizzi’s method to capture the essence of participants lived experiences and the sample population consisted of 12 participants. Findings revealed two overarching themes and in the themes several subthemes that include: Emotional Regulation, Social Presence, Stress Relief, Gaming as Social Connection and Maintenance and lifestyle balance. Participants described gaming as central to sustaining meaningful relationships, regulating stress, exploring identity, and receiving …

Healthcare Disparities Related To Income In South Carolina, Rebekka Byrd

Doctoral Dissertations and Projects

Low-income individuals and families in South Carolina face significant barriers to accessing healthcare, despite the presence of public health programs like Medicaid. Many fall into the healthcare coverage gap, earning too much to qualify for Medicaid but too little to afford private insurance. This study explored the consequences of the healthcare coverage gap by examining the relationships between income, healthcare access, and the ability to afford healthcare services among 500 adults aged 19–64 who participated in the National Health Interview Survey between 2018 and 2023. Utilizing a retrospective quantitative analysis of secondary data from the National Health Interview Survey (NHIS) …

Investigation In The Association Of Opioid Administration And Access To A Primary Care Provider In Patients Who Frequently Use The Emergency Department In A Rural And Urban Hospital In Arkansas, Cheyenne Star Lowrey-Lagrone

Doctoral Dissertations and Projects

The overuse of emergency department (ED) services presents challenges for hospitals and communities as valuable resources are funneled repeatedly into the same patients. Frequent ED users account for a significant portion of used resources, and efforts have been made to address this public health concern. This paper sought to identify associations between opioid administration and access to a PCP in one rural and one urban hospital in Arkansas. Through an investigation of 200 medical records of ED users identified as frequent users of one rural (n=100) and one urban (n=100) hospital between 2018 and 2023, the researcher identified associations between …

Implementation Of Enhanced Recovery After Surgery Protocols To Improved Maternal Pain Management, Stefanie Sherman

Doctoral Dissertations and Projects

Cesarean sections remain the most common surgical procedures in the United States, but they come with significant risks, including increased pain, infection, longer recovery, and higher health care costs. Enhanced Recovery After Surgery (ERAS) guidelines outline an evidence- based, multidisciplinary approach that optimizes surgical recovery and improves outcomes. The primary goal of this project was to evaluate the impact of the implementation of ERAS guidelines in a community hospital with women undergoing scheduled cesarean sections on postoperative pain management as measured by aggregate pain scores. The Iowa Model of Evidence-Based Practice was used to guide this quasi-experimental pre-post project, which …

An Assessment Of Cognitive Fatigue Among Emergency Medical Services (Ems) Professionals In The State Of Georgia, Charlotte L. Bush

Doctoral Dissertations and Projects

The purpose of this dissertation was to delve into the urgent and pervasive issue of cognitive fatigue in Emergency Medical Services (EMS) personnel, a critical yet often overlooked aspect of healthcare delivery. EMS personnel operate in high-stress, unpredictable environments, frequently working long hours and overnight shifts, which can lead to significant fatigue. This study aimed to identify the primary causes of cognitive fatigue in this population, examine its impact on decision-making abilities and patient care outcomes, and evaluate the effectiveness of current fatigue management strategies. The research employed a comprehensive mixed-methods approach, combining quantitative data from surveys and qualitative data …

The Effects Of Escape Room Simulations On Stress Levels Of Sophomore Baccalaureate Nursing Students: An Experimental Study, Bethany L. Mcfann

Doctoral Dissertations and Projects

The purpose of this quantitative experimental pretest -posttest design using an experimental and control group was to determine if gaming escape room simulation will decrease BSN nursing students' stress in high fidelity simulation (HFS). The sample size of 64 students had 32 students randomly assigned to each group, the control and the experimental group. The first-year sophomore Bachelor of Science in nursing (BSN) students at a state university were randomly assigned to either traditional or escape room simulation scenarios. Stress levels of each group were measured using the State-Trait Anxiety Inventory (STAI) tool before and after the simulations with statistical …

Exploring The Relationship Between Maternal-Fetal Training And Maternal Desert Workers’ Compassion Fatigue: A Predictive Correlational Study, Marissa Lemley Brown

Doctoral Dissertations and Projects

The purpose of this quantitative, predictive correlational study was to explore the relationship between maternal-fetal training and maternal desert workers’ compassion satisfaction, burnout, and secondary traumatic stress in the southeastern region of the United States. Maternal deserts are defined as areas without dedicated obstetric services and impact more than 28 million childbearing-age women. These areas are becoming more prevalent, leaving healthcare workers to face caring for maternal-fetal health concerns in generalist areas. The study utilized a predictive correlational design to analyze relationships where multiple variables could influence the study. Stamm’s Professional Quality of Life V-5 (ProQOL) scale was used to …

The Lived Experiences Of Mothers Of Children With Down Syndrome Using Teleot Services: A Phenomenological Study, Tumini Umukoro

Doctoral Dissertations and Projects

In response to the COVID-19 lockdown in the United States, therapy services for children with developmental delays transitioned to telehealth services. The purpose of this qualitative study was to explore the lived experiences of mothers of children diagnosed with Down syndrome (DS) who received occupational therapy services through telehealth (teleOT) using interpretative phenomenological analysis (IPA). Bronfenbrenner's ecological system theory was the framework used to address the research questions: RQ1: What are the lived experiences of mothers of children with DS regarding teleOT services? RQ2: How do mothers of children with DS perceive the benefits and challenges of telehealth OT services? …

Information About Task Duration Influences Energetic Cost During Split-Belt Adaptation And Retention Of Walking Patterns Post-Adaptation, Samantha N. Jeffcoat, Adrian Aragon, Andrian Kuch, Shawn Farrokhi, Andrew Hooyman, Russell Johnson, Natalia Sanchez

Physical Therapy Faculty Articles and Research

Studies of locomotor adaptation have shown that adaptation can occur in short bouts and can continue for long bouts or across days. Information about task duration might influence the adaptation of gait features, given that task duration influences the time available to explore and adapt the aspects of gait that reduce energy cost. We hypothesized that information about task duration and frequency of updates influences adaptation to split-belt walking based on two competing mechanisms: individuals anticipating a prolonged adaptation period may either (1) extend exploration of energetically suboptimal gait patterns, or (2) adapt toward a more energy-efficient pattern earlier to …