Medicine and Health Sciences Commons^™

The Role Of 3d Printing Technology To Achieve Egypt 2030 Sustainable Development Vision, أسماء أحمد عزه صبحي, مي مدكور

Journal of Engineering Research

هذه الدراسة تركز علي فهم تأثير تكنولجيا الطباعة ثلاثية الأبعاد علي مجال العمارة والبناء المستدام، مع التركيز على جوانب الاستدامة البيئية الاقتصادية والاجتماعية كما توضح الدراسات السابقة المعتمده علي التحليل النقدي أن الطباعة ثلاثية الأبعاد بديلاً مستدامًا مع ما يصل إلى 49% أقل من البصمة البيئية و78% أكثر فعالية من حيث التكلفة مقارنة بتقنيات البناء التقليدية وتواجه صناعة البناء في جمهورية مصر العربية مجموعة من التحديات مثل عدم دمج تقنيات الطباعة ثلاثية الأبعاد في صناعة البناء في مصر بما توفره من إمكانيات تساعد في الوصول لمباني أكثر استدامة بما يحقق متطلبات رؤية مصر 2030 للتنمية المستدامة بالاضافة …

A Comparative Analysis In Energy Efficiency In Buildings To Support Clean Energy Transitions In Architecture, Nourhane M. El-Haridi

Journal of Engineering Research

Over the past few decades, there has been a growing recognition of the importance of energy efficiency policies in designing buildings for supporting clean energy transitions. Buildings account for a significant share of global energy consumption and greenhouse gas emissions, and improving their energy efficiency in the design phase can reduce energy use and emissions, while also providing numerous other benefits such as cost savings, improved comfort and health, and job creation. Many countries have already implemented energy efficiency policies in buildings, such as building codes, standards, labeling schemes, and financial incentives in addition to governmental regulations. Since the governments …

Activating Urban Spaces To Achieve Social Sustainability In Closed Residential Communities, ولاء أحمد نو زة صبحي السقا , أحمد السيد الشناوي , سارة حسني شعلان

Journal of Engineering Research

تماشيا مع توجهات الجمهورية الجديدة و رؤية مصر 2030 من أجل خلق مجتمعات سكنية مستدامة تلبي احتياجات سكانيها الاجتماعية .وقد ادي انتشار المجتمعات السكنية المغلقة الي وجود مشكلة اجتماعية لسكانها من عزلة و انحصارهم داخلها وانفصالهم عن المجتمع المحيط بهم وعن سكان باقي المدينة وبالتالي ظهرت مشاكل اجتماعية مثل العزلة و الشعور بالوحدة وفقدان الانتماء الاجتماعي وزيادة الانفصال.لذلك يتناول البحث تفعيل دور الفراغات العمرانية وتاثيرها علي العلاقة الاجتماعية بين ساكني تلك التجمعات المغلقة والتاكيد علي ضرورة تطبيق تلك المعايير التصميمية لتلبية احتياجات السكان الاجتماعية. لما للفراغ العمراني من دور مهم في ممارسة الانشطة و الفاعليات التي من شانها تحقيق التواصل …

Evaluation Of The Built Environment Performance In Light Of Sustainable And Universal Design: Criteria And Methods, N.A.Mohamed E. A. Morghany, M. E. Khalil

Journal of Engineering Research

Egypt's Vision 2030 for Sustainable Development Strategy (SDS) emphasizes social inclusion and accessibility. The concept of Universal Design (UD) is crucial in achieving the goals of SDS by facilitating utilization and access to the built environment for all.

Palm Agricultural Residues As A Sustainable Local Construction Material For Siwa House: One Click Life Cycle Assessment Perspective, Nader Mohamed Gharib,

Journal of Engineering Research

This study focuses on conducting a life cycle assessment (LCA) of using green agricultural waste as a sustainable local building material compared to conventional materials. Agricultural residues present a major waste management issue, however they can be repurposed as renewable construction resources. The aim is to quantify the environmental impacts of an experimental palm midribs roof design versus a traditional reinforced concrete roof. by using One Click LCA software to model the two design scenarios and analyze key sustainability indicators including carbon emissions. By comparing the LCA results, the study benchmarks the global warming potential and identifies opportunities to promote …

The Role Of Interior Architecture In Developing Sustainable Educational Building Spaces And Its Impact On Users In University Institutions, زينب ناجي¹ ريم الحداد

Journal of Engineering Research

يهدف البحث الى تسليط الضوء على أهمية الاستدامة في التصميم وما تحققه من جوانب ايجابية على الفرد والمجتمع، حيث أن أبنية العمارة المستدامة هي التي يتم تصميمها وإنشاءها بطرق ومواد البناء المحلية والتي لا تؤثر سلبيا على البيئة وصحة المستعملين والقائمين بالبناء وتحافظ على حقوق الأجيال القادمة، وتتناول الأبنية المستدامة العديد من الإعتبارات ومنها إستعمالات الأراضي والتأثير على الموقع والبيئة المحيطة وإستنزاف الطاقة والمياه. و يصبح المبنى الذي يبنى على أساس العمارة المستدامة مفيد لأنه يعتمد على تحسين كفاءة الطاقة المستخدمة وبالتالي توفير المال، والحد من التلوث بزيادة نقاء الهواء الذي يوفر لمستخدمي المبنى بيئة صحية سليمة بالإضافة الى المحافظة …

Opportunities And Challenges For Achieving Sustainable Architectural Education In Egypt, In Light Of Universal Design Approach., مي عيد خليل أحمد م/ هناء شعبان حسن

Journal of Engineering Research

الملخص يعتبر التعليم الجامعي هو المفتاح لتغيير الثقافة المهنية في مجالات التصميم، لذا يقع على عاتق المؤسسات التعليمية مسؤولية التعليم والتثقيف للطلاب الجامعيين، حيث يقدم التعليم المعماري حلولاً مجدية للقضايا الدولية الملحة من خلال تحقيق أهداف التنمية المستدامة والتي صاغتها الأمم المتحدة، يمكن التغلب على هذه القضايا من خلال تطبيق مفهوم التصميم العالمي (الشامل) UD والذي يسعي لتبسيط الحياه علي الجميع وتحقيق الوصول والاستخدام اليسير للجميع بغض النظر عن القدرات البدنية والأعمار.

Challenges Of New And Renewable Energy In The Face Of Climate Change: An Introduction To Evaluating The Egyptian Experience, نهي أحمد عبد المنعم السيد, شاهيناز محمد علي طايع Dr, Nevine Gado Dr.

Journal of Engineering Research

أصبحت التغيرات المناخية وما يترتب عليها من المخاطر البيئية قضية من القضايا الحيوية والتي عقدت لها عدة مؤتمرات دولية مثل مؤتمر المناخ العالمي COP 27 والذي استضافته مصر في عام 2023 لوضع الحلول لتلك الأزمة. ومن أجل ذلك أصبح مردود الطاقة الجديدة والمتجددة احدى اليات وادوات التعامل مع هذه القضية الحيوية كبديل مستدام وصديق للبيئة.

The Impact Of Digital Twin On Real Estate Marketing, نوران عاطف محمد غانم Eng, مروة أحمد قمر الدولة أ.د أحمد عبد الوهاب أحمد رزق

Journal of Engineering Research

يتناول هذا البحث أولا الدراسات النظرية الأكثر حداثة التي تناولت تقنية التوأمة الرقمية وعلاقتها بالعقارات وتسويقها ونشأتها ومفهومها ومكوناتها، ثم انتقلنا الي الدراسات المخصصة لاستخداماتها في قطاع العقارات وأهميتها، ومن بعد تناولنا استخدامتها في التسويق العقاري بصفة خاصة من حيث المشاريع والبرامج. ومن ثم وضحنا أهمية تقنية التوأمة وتأثيرها علي التسويق العقاري من حيث العملاء والشركات والأسواق، وبعد ذلك تناولنا تطبيق للتسويق العقاري باستخدام تقنية التوأمة الرقمية علي التخطيط العمراني وكيفية تأثيره علي تسويق المشروع. ومن خلال القيام بدراسة استبيان لقياس أهمية تأثير تقنية التوأمة الرقمية علي أراء العملاء وتفضيلاتهم في اتخاذ القرارات واختيارهم للشركات حين ذاك، وربط تقنية التوأمة …

Sensory Garden Preferences For Autism Spectrum: Insights From Psychologists And Urban Designers, Maram Adel Ebaid

Journal of Engineering Research

Sensory gardens are outdoor environment that stimulate the senses and promote well-being for people with autism spectrum disorder (ASD). In Egypt, there is an absence of gardens, compounded by a limited understanding of the design principles aligned with the needs of people with ASD. The research explores sensory garden features and the specific challenges faced by people with ASD. To bridge this gap, the methodology depends on qualitative approach through interviews with psychology and urban design experts. The results highlight the correlation between prevalent strategies among people with ASD and the elements of sensory gardens, considering both soft and hard …

Incorporation Of Bim Techniques In The Architectural Engineering Curriculum, Ahmed Ahmed M. Saleh, Sherif S. Abdalla

Journal of Engineering Research

In this era, the age of the digital revolution, Egyptian engineering universities and academies compete by integrating new technologies such as building information modeling (BIM) inside the educational curriculum. The research aims to examine and integrate BIM techniques within the course specifications in Egyptian universities and academies, majoring in architectural engineering pathing through the four levels of credit hours system so that, teaching the BIM courses is not limited to one or two only. Furthermore, the current situation of BIM maturity levels, dimensions, and tools implementation in some architecture universities and academies curriculum will be determined and monitored. As a …

Operating Efficiency In Accommodation Units And Its Impact On The Design Of Comprehensive Single Patient Rooms In Hospitals, نهال نبيل محمد مصطفي ، احمد هلال محمد محمد ، نادي مصطفي عبد الكريم

Journal of Engineering Research

هناك الكثير من التحديات التشغيلية والتنظيمية التي تواجهها المجموعات المهنية المختلفة داخل وحدات الإقامة في المستشفيات بسبب عدم كفاية معايير التصميم الموضوعة بالاحتياجات المطلوبة خاصة بغرف المرضي، ومن اهم التحديات التي يواجهها الاطباء وفرق التمريض والفنيين وغيرهم. القدرة السلسة على دخول غرفة المريض والتفاعل مع عناصر الغرفة بشكل واضح دون حدوث تصادمات او احتكاكات، كذلك القدرة علي القيام بالأعمال التحضيرية المتعلقة بالأنشطة التمريضية المطلوبة داخل غرف المرضي وتشمل كافة الأنشطة التي يقوم بها الشخص المهني سواء اكان طبيب ام تمريض ام فني منذ لحظة دخوله غرفة المريض وحتي اداءه المهمة المطلوبة. ويجب ان تتم هذه المهام بشكل مريح وباستجابة سريعة …

Health Policy: Food Allergy Restaurant Education Law, Joanna Ko

Doctor of Nursing Practice Projects

Food allergies are a rising public health concern with no indication of deceleration. The purpose of this Doctor of Nursing Practice (DNP) project is to enact an Arkansas state law to protect the food allergy community in dining out at restaurants to increase quality of life and decrease adverse allergic reactions. The current Arkansas state legislation for restaurant food allergy employee training is absent and action needs to be taken to safeguard the food allergy community from life-threatening reactions. The methodology involved contacting the six states that have previously implemented similar food allergy legislation. It encompassed performing a thorough search …

Apomorphine Titration With And Without Anti-Emetic Pretreatment In Patients With Parkinson’S Disease Experiencing Off Episodes: A Modified Delphi Panel, Stuart H. Isaacson, Richard Dewey, Robert A. Hauser, Daniel Kremens, Rajeev Kumar, Mark Lew, William Ondo, Fernando Pagan, Kelly E. Lyons, Rajesh Pahwa

Department of Neurology Faculty Papers

INTRODUCTION: In the United States (US), prophylactic treatment with the antiemetic trimethobenzamide has been used before initiating apomorphine therapy. However, US trimethobenzamide stores have been depleted, leaving uncertainty regarding whether antiemetic pretreatment is needed.

METHODS: This modified Delphi panel aimed to inform circumstances when apomorphine is initiated without antiemetic pretreatment. During Round 1, a panel of 9 US movement disorder specialists rated the appropriateness of prescribing apomorphine therapy with and without antiemetic pretreatment across 192 patient scenarios and were able to review their scores in relation to other scores. During the Round 2, consensus was defined for each scenario as …

Voices Of Wisdom: Geriatric Interviews On Self-Management Of Type 2 Diabetes In The United States-A Systematic Review And Metasynthesis, David F Lo, Ahmed Gawash, Kunal P Shah, Jasmine Emanuel, Brandon Goodwin, Don D Shamilov, Gaurav Kumar, Nathan Jean, Christian P White

Rowan-Virtua School of Osteopathic Medicine Departmental Research

This review is aimed at unraveling the intricacies of diabetic self-management among geriatric people, drawing on current insights and understanding the complex paths geriatric people navigate. A wide search was conducted in health-oriented databases, including CINAHL, Embase, PsycINFO, MEDLINE, PubMed, Web of Science, and Cochrane Library, while gray literature was excluded. The search combined keywords and subject headings, focusing on the geriatric population, diabetes, self-management, and qualitative research. A three-tiered screening process was employed, with titles and then abstracts initially reviewed. Full-text analysis followed, with disagreements resolved among reviewers. In total, there were 248 participants included across these eight studies. …

The Effect Of Cesarean Delivery On The Neonatal Gut Microbiome In An Under-Resourced Population In The Bronx, Ny, Usa, Sandra E Reznik, Ayodele J Akinyemi, David Harary, Mariam S Latuga, Mamta Fuloria, Maureen J Charron

SKMC Student Presentations and Publications

BACKGROUND: Neonatal and early-life gut microbiome changes are associated with altered cardiometabolic and immune development. In this study, we explored Cesarean delivery effects on the gut microbiome in our high-risk, under-resourced Bronx, NY population.

RESULTS: Fecal samples from the Bronx MomBa Health Study (Bronx MomBa Health Study) were categorized by delivery mode (vaginal/Cesarean) and analyzed via 16 S rRNA gene sequencing at four timepoints over the first two years of life. Bacteroidota organisms, which have been linked to decreased risk for obesity and type 2 diabetes, were relatively reduced by Cesarean delivery, while Firmicutes organisms were increased. Organisms belonging to …

Adapting An Intervention To Address Barriers To Pain Management In Hospice: Formative Research To Inform Empower-D For Dementia Caregivers, Karla T Washington, Morgan L Van Vleck, Todd D Becker, George Demiris, Debra Parker Oliver, Paul E Tatum, Jacquelyn J Benson, John G Cagle

2020-Current year OA Pubs

BACKGROUND: Nearly half of more than 1.7 million older Americans who receive hospice care each year have a primary or comorbid diagnosis of dementia. Pain is often undertreated in this patient population owing to myriad factors, including unmet informational needs among family caregivers.

OBJECTIVE: We sought to inform the adaptation of a pain education intervention for hospice family caregivers to the context of dementia by eliciting feedback on the educational content covered in adapted intervention materials.

DESIGN: We conducted a multimethod, formative research study to inform the adaptation of an existing, evidence-based intervention.

SETTING/SUBJECTS: The study included a purposively recruited …

Toward Concurrent Identification Of Human Activities With A Single Unifying Neural Network Classification: First Step, Andrew Smith, Musa Azeem, Chrisogonas O. Odhiambo, Pamela J. Wright Phd, Ms, Med, Rn, Cen, Hanim E. Diktas, Spencer Upton, Corby K. Martin, Brett Froeliger, Cynthia F. Corbett, Homayoun Valafar

Publications

The characterization of human behavior in real-world contexts is critical for developing a comprehensive model of human health. Recent technological advancements have enabled wearables and sensors to passively and unobtrusively record and presumably quantify human behavior. Better understanding human activities in unobtrusive and passive ways is an indispensable tool in understanding the relationship between behavioral determinants of health and diseases. Adult individuals (N = 60) emulated the behaviors of smoking, exercising, eating, and medication (pill) taking in a laboratory setting while equipped with smartwatches that captured accelerometer data. The collected data underwent expert annotation and was used to train a …

Towards Addressing Mental Health In Rural Louisiana: Blueberry Supplementation As A Natural Intervention, Katy E. Venable

LSU Doctoral Dissertations

Depression and anxiety are major public health issues; however, there is an unmet need for novel effective and accessible treatments, particularly in rural communities. Blueberries are an unexplored nutraceutical for these conditions due to their excellent nutritional profile, with particularly high levels of polyphenols and anthocyanins and benefits on mood, cognition, and health. Therefore, we conducted a double-blind, randomized pilot study in a rural population. We employed a cross-over design to test the effects of 12 weeks daily ingestion of 24 g of whole freeze-dried blueberry powder versus placebo on symptoms of depression and anxiety in those diagnosed with depression …

Set-Based Tests For Genetic Association Studies With Interval-Censored Competing Risks Outcomes, Zhichao Xu, Jaihee Choi, Ryan Sun

Faculty, Staff and Student Publications

Over the past decade, massive genetic compendiums such as the UK Biobank have gathered extensive genetic and phenotypic data that hold the potential to provide unparalleled insight into the genetic etiologies of various complex diseases. However, much of the disease information is collected as time-to-event outcomes in interval-censored form, and conventional tools for genetic association analysis are often not available for this type of data. For example, set-based inference for common and rare variants analysis is a fundamental investigation in germline genetics studies, but there is a lack of approaches that can perform set-based testing when the interval-censored outcome of …

Wearable Device Case-Study: Unveiling Physiological Stress Patterns In A Neurosurgeon Operating Multiple Surgeries, Andy Suarez, Justin Braun, Gabriel J. Sanders, Yoav Ritter, Steven Vanni, Jaime Tartar, Corey A. Peacock

Journal for Sports Neuroscience

Introduction

Utilizing a wearable device, this case study aims to measure stress at different surgical durations to bridge the gap in research regarding the physiological stress of surgery. Significant stress variations throughout the surgeries are anticipated, which will provide valuable insight into the patterns of physiological stress experienced by our neurosurgeon.

Materials and Methods

One male neurosurgeon subject (n=1; age: 48; height: 188 cm; weight: 87.3 kg) conducted 82 surgeries (2023-2024). A wearable device (Whoop 4, Boston, MA) was used to monitor maximum heart rate (MAXHR), average heart rate (AVGHR), calories (CAL), strain (STR) and surgery duration (MIN). Surgeries were …

Medical School Watercooler Newsletter - July 12, 2024, Lindsay Hughes

Watercooler Newsletter

This is the July 12, 2024 edition of the Frederick P. Whiddon College of Medicine’s newsletter - Watercooler.

Contents Include

• USA scientist receives $300,000 grant for Alzheimer’s pilot study
• Medical students teach campers lessons in STEM and life
• Whiddon COM employees participate in staff retreat
• Pathology celebrates graduating residents, research symposium winners announced

Medial Patellofemoral Ligament Augmented With A Reinforced Bioinductive Implant Is Biomechanically Similar To The Native Medial Patellofemoral Ligament At Time Zero In A Cadaveric Model, Sean Mcmillan, Seth Sherman, Zachary Brown, Erik Brewer, Elizabeth Ford

Rowan-Virtua School of Translational Biomedical Engineering & Sciences Departmental Research

Purpose: To biomechanically compare primary medial patellofemoral ligament (MPFL) repair (MPFLr) augmented with a reinforced bioinductive implant (RBI) to the native MPFL ligament and a semitendinosus (semi-T) MPFL reconstruction (MPFLR) at time zero. Methods: Four fresh-frozen matched pair cadavers (8 knees) were used to biomechanically compare the native MPFL to augmented MPFLr (n = 4) and semi-T MPFLR (n = 4). The native MPFL (n = 8) was isolated, preserving the femoral and patellar attachments, and pulled to failure. The semi-T was harvested from 1 of the matched pairs and whipstitched, as was a 250-mm × 5-mm RBI. A standard …

Ergonomics And Musculoskeletal Disorders: An Evaluation Of Self-Assessment Using Surveys, Shannon L. Sherman

Dental Hygiene ETDs

Musculoskeletal disorders, MSDs, are a serious issue many dental professionals experience. It is understood that improper ergonomics are a contributing factor to developing MSDs. Several factors can be implemented into a dental hygienist’s everyday routine to help decrease the risk of developing musculoskeletal disorders. The purpose of this study was to investigate how many practicing dental hygienists experience musculoskeletal pain from daily hygiene practice and how ergonomics contributes to their level of pain. The study also discovered through self-assessment, areas participating dental hygienists would be willing to improve on in their daily ergonomic practice to potentially help decrease or prevent …

Dental Hygiene Burnout In Clinical Practice From Covid-19; A Pilot Study Using Self-Reported Questionaire, Yvette Valladares

Dental Hygiene ETDs

The purpose of this study was to determine if the Covid-19 pandemic had increased feelings of burnout in registered dental hygienists who were employed in clinical practice before and during 2020. A survey of registered dental hygienists in California was employed. Participants completed a modified Maslach Burnout Inventory, to evaluate emotional exhaustion (EE), depersonalization (DP), and personal accomplishment (PA). One open-ended question explored specific aspects of Covid-19 contributing to burnout. 162 surveys were completed and 139 met the inclusion criteria. Data analysis revealed that 40.29% reported high Emotional Exhaustion, 43.17% experienced low Depersonalization, and 85.61% reported high Personal Achievement. Lastly, …

Real-World Evidence Study On The Early Use Of Cemiplimab In The Uk: React-Cemi (Real World Evidence Of Advanced Cscc Treatment With Cemiplimab), Amarnath Challapalli, Grant Stewart, Heather Shaw, Peter John Davies, Juan Carlos Lopez-Baez, Edward C Ottley, Stephen Kelly

Faculty, Staff and Student Publications

BACKGROUND: Cemiplimab was licensed in the United Kingdom (UK) in 2019 for the treatment of patients with locally advanced and metastatic CSCC not suitable for curative surgery or radiotherapy (advanced CSCC [aCSCC]). No UK multi-center studies have investigated the real-world experience of cemiplimab post marketing authorization in aCSCC.

METHODS: This non-interventional retrospective study (10 UK centers) involved data collection from medical records of patients with aCSCC who initiated cemiplimab treatment between 2 July 2019 and 30 November 2020. The study period was a minimum of 12 and a maximum of 36 months post cemiplimab initiation. The primary objective was to …

East African Refugee Women Seeking Health Care After Government Assistance Ends, Sylivia Chelimo

Walden Dissertations and Doctoral Studies

East African refugee women arrive as a vulnerable population in their host country. Before coming to the United States, refugee women may have experienced varying levels of trauma due to civil wars, genocide, sexual assault, deaths of loved ones, terrorist attacks, being taken hostage, and torture in their home country. The purpose of this generic qualitative study was to explore the experiences of refugee women from East African countries seeking health care in the Central United States when government assistance ends. The framework of the behavioral model of health was the guide for examining the experiences of the participant refugee …

Experiences Of Black Males With Generalized Anxiety Disorder During The Covid-19 Pandemic, Cynthia Lynn Williams

Walden Dissertations and Doctoral Studies

This qualitative research dissertation involved exploring the intersection of race, gender, and mental health via lived experiences of Black males who were diagnosed with generalized anxiety disorder during the COVID-19 pandemic to provide a comprehensive understanding of how the unique sociocultural context of the pandemic influenced their experiences with anxiety. Using a qualitative Interpretive Phenomenological Analysis research design and semi-structured interviews with a diverse sample of seven Black males living in various regions of the United States the interviews involved their personal experiences, coping mechanisms, and perceptions of societal and systemic factors that affected their mental health during the pandemic. …

Genetic And Multi-Omic Resources For Alzheimer Disease And Related Dementia From The Knight Alzheimer Disease Research Center, Maria Victoria Fernandez, Menghan Liu, Aleksandra Beric, Matt Johnson, Arda Cetin, Maulik Patel, John Budde, Pat Kohlfeld, Kristy Bergmann, Joseph Lowery, Allison Flynn, William Brock, Brenda Sanchez Montejo, Jen Gentsch, Nicholas Sykora, Joanne Norton, Jen Gentsch, Olga Valdez, Priyanka Gorijala, Jessie Sanford, Yichen Sun, Ciyang Wang, Dan Western, Jigyasha Timsina, Tassia Mangetti Goncalves, Anh N Do, Yun Ju Sung, Guoyan Zhao, John C Morris, Krista Moulder, David M Holtzman, Randall J Bateman, Celeste Karch, Jason Hassenstab, Chengjie Xiong, Suzanne E Schindler, Joyce Joy Balls-Berry, Tammie L S Benzinger, Richard J Perrin, Andrea Denny, B Joy Snider, Susan L Stark, Laura Ibanez, Carlos Cruchaga

2020-Current year OA Pubs

The Knight-Alzheimer Disease Research Center (Knight-ADRC) at Washington University in St. Louis has pioneered and led worldwide seminal studies that have expanded our clinical, social, pathological, and molecular understanding of Alzheimer Disease. Over more than 40 years, research volunteers have been recruited to participate in cognitive, neuropsychologic, imaging, fluid biomarkers, genomic and multi-omic studies. Tissue and longitudinal data collected to foster, facilitate, and support research on dementia and aging. The Genetics and high throughput -omics core (GHTO) have collected of more than 26,000 biological samples from 6,625 Knight-ADRC participants. Samples available include longitudinal DNA, RNA, non-fasted plasma, cerebrospinal fluid pellets, …

Pulmonary Osteoclast-Like Cells In Silica Induced Pulmonary Fibrosis, Yoshihiro Hasegawa, Steven L Teitelbaum, Et Al.

2020-Current year OA Pubs

The pathophysiology of silicosis is poorly understood, limiting development of therapies for those who have been exposed to the respirable particle. We explored mechanisms of silica-induced pulmonary fibrosis in human lung samples collected from patients with occupational exposure to silica and in a longitudinal mouse model of silicosis using multiple modalities including whole-lung single-cell RNA sequencing and histological, biochemical, and physiologic assessments. In addition to pulmonary inflammation and fibrosis, intratracheal silica challenge induced osteoclast-like differentiation of alveolar macrophages and recruited monocytes, driven by induction of the osteoclastogenic cytokine, receptor activator of nuclear factor κΒ ligand (RANKL) in pulmonary lymphocytes, and …