Medicine and Health Sciences Commons^™

Clinical-Transcriptional Prioritization Of The Circulating Proteome In Human Heart Failure, Andrew S Perry, Junedh Amrute, Kory J Lavine, Et Al.

2020-Current year OA Pubs

Given expanding studies in epidemiology and disease-oriented human studies offering hundreds of associations between the human "ome" and disease, prioritizing molecules relevant to disease mechanisms among this growing breadth is important. Here, we link the circulating proteome to human heart failure (HF) propensity (via echocardiographic phenotyping and clinical outcomes) across the lifespan, demonstrating key pathways of fibrosis, inflammation, metabolism, and hypertrophy. We observe a broad array of genes encoding proteins linked to HF phenotypes and outcomes in clinical populations dynamically expressed at a transcriptional level in human myocardium during HF and cardiac recovery (several in a cell-specific fashion). Many identified …

Vglut2-Based Glutamatergic Signaling In Central Noradrenergic Neurons Is Dispensable For Normal Breathing And Chemosensory Reflexes, Yuan Chang, Savannah Lusk, Andersen Chang, Christopher S Ward, Russell S Ray

Faculty, Staff and Students Publications

Central noradrenergic (NA) neurons are key constituents of the respiratory homeostatic network. NA dysfunction is implicated in several developmental respiratory disorders including Congenital Central Hyperventilation Syndrome (CCHS), Sudden Infant Death Syndrome (SIDS), and Rett Syndrome. The current unchallenged paradigm in the field, supported by multiple studies, is that glutamate co-transmission in subsets of central NA neurons plays a role in breathing control. If true, NA-glutamate co-transmission may also be mechanistically important in respiratory disorders. However, the requirement of NA-derived glutamate in breathing has not been directly tested and the extent of glutamate co-transmission in the central NA system remains uncharacterized. …

Host-Derived Ceacam-Laden Vesicles Engage Enterotoxigenic Escherichia Coli For Elimination And Toxin Neutralization, Alaullah Sheikh, Debayan Ganguli, Tim J Vickers, Marjahan Akhtar, Nazia Khatoon, Bipul Setu, Supratim Basu, Wandy L Beatty, James M Fleckenstein, Et Al.

2020-Current year OA Pubs

Enterotoxigenic

Myotube Guidance: Shaping Up The Musculoskeletal System, Aaron N Johnson

2020-Current year OA Pubs

Myofibers are highly specialized contractile cells of skeletal muscles, and dysregulation of myofiber morphogenesis is emerging as a contributing cause of myopathies and structural birth defects. Myotubes are the myofiber precursors and undergo a dramatic morphological transition into long bipolar myofibers that are attached to tendons on two ends. Similar to axon growth cones, myotube leading edges navigate toward target cells and form cell-cell connections. The process of myotube guidance connects myotubes with the correct tendons, orients myofiber morphology with the overall body plan, and generates a functional musculoskeletal system. Navigational signaling, addition of mass and volume, and identification of …

Adamts12 Promotes Fibrosis By Restructuring Extracellular Matrix To Enable Activation Of Injury-Responsive Fibroblasts, Konrad Hoeft, Benjamin D. Humphreys, Et Al.

2020-Current year OA Pubs

Fibrosis represents the uncontrolled replacement of parenchymal tissue with extracellular matrix (ECM) produced by myofibroblasts. While genetic fate-tracing and single-cell RNA-Seq technologies have helped elucidate fibroblast heterogeneity and ontogeny beyond fibroblast to myofibroblast differentiation, newly identified fibroblast populations remain ill defined, with respect to both the molecular cues driving their differentiation and their subsequent role in fibrosis. Using an unbiased approach, we identified the metalloprotease ADAMTS12 as a fibroblast-specific gene that is strongly upregulated during active fibrogenesis in humans and mice. Functional in vivo KO studies in mice confirmed that Adamts12 was critical during fibrogenesis in both heart and kidney. …

Design Considerations For Self-Management Technologies For People Living With Dementia And Informal Carers – Perspectives Of Healthcare Professionals And Charity Workers, Dympna O'Sullivan

Conference papers

Dementia is a neurodegenerative disorder that leads to decline in memory, language, reasoning, and the ability to perform daily activities. It is linked to poorer quality of life for the person with dementia and their informal (unpaid) carers. While early intervention and access to adequate care are critical in slowing dementia's progression and better managing associated symptoms, dementia is frequently only diagnosed at an advanced stage and care is often fragmented. To better understand how to meet the complex needs of persons living with dementia and their informal carers, 10 healthcare professionals and 10 charity workers from relevant community and …

Wmdds Bulletin Summer 2020

West Michigan District Dental Society Bulletin

In the Summer 2020 issue, the reader will find the following feature articles:

• Ask an Expert: What Does This New Legislation Around PPP Mean for Me?
• COVID-19 Pandemic Results in Severe Operating Room Access Limitations for Pediatric Dentists

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.

Wmdds Bulletin Winter 2020

West Michigan District Dental Society Bulletin

In the Winter 2020 issue, the reader will find the following feature articles:

• 2020 Silent Bell Recipient: W. Erick Rupprecht, DDS
• Dentists Beyond the Chair: Aquarist and Fish Breeder – Chase Klinesteker, DDS

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.

Wmdds Bulletin Spring 2020

West Michigan District Dental Society Bulletin

In the Spring 2020 issue, the reader will find the following feature articles:

• Treating Emergency Patients During the COVID-19 Pandemic
• Expanding the ”Quaranteam"
• Dentists Beyond the Chair: Competitive Dancers – David Armbrecht, DMD, and Sally Kotani, DDS

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.

Wmdds Bulletin Holiday 2020

West Michigan District Dental Society Bulletin

In the Holiday 2020 issue, the reader will find the following feature articles:

• Evidence-Based Dentistry: Learning from a Local Expert
• Dentists Doing Good: Dr. Dan Armstrong, Exalta Health
• Dentists Beyond the Chair: Chairman of Board of Directors for Pankey Institute

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.

Wmdds Bulletin Fall 2020

West Michigan District Dental Society Bulletin

In the Fall 2020 issue, the reader will find the following feature articles:

• Looking to Leadership: Personal Experiences During the Pandemic
• Dentists Doing Good: WMDF Golf Outing
• Dentists Beyond the Chair: Maintaining a Pollinator Habitat and 52 Acre Farm
• 2020 WMDDS Directory Corrections/Additions

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.

Wmdds Bulletin Directory 2020

West Michigan District Dental Society Bulletin

In the 2020 WMDDS Directory issue, the reader will find a comprehensive listing of WMDDS members for 2020.

Wmdds Bulletin Directory 2021

West Michigan District Dental Society Bulletin

In the 2021 WMDDS Directory issue, the reader will find a comprehensive listing of WMDDS members for 2021.

Wmdds Bulletin Directory 2022

West Michigan District Dental Society Bulletin

In the 2022 WMDDS Directory issue, the reader will find a comprehensive listing of WMDDS members for 2022.

Partial Purification Of Alzheimer’S Amyloid-𝛽 Specific Antibody Using Ammonium Sulfate, Noor Yousaf

Undergraduate Research Symposium

Alzheimer's disease (AD) is the most common neurodegenerative disease. The trigger for AD is the accumulation of amyloid-beta protein (Aβ) as senile plaques in the brain. Prior to forming the fiber-like structures found in the plaques, Aβ undergoes an oligomerization process that produces intermediate structures called protofibrils. Substantial data from the Nichols laboratory demonstrated that soluble Aβ protofibrils were highly inflammatory compared to other forms of Aβ. Based on these findings, a serum polyclonal antibody, named Antibody St. Louis or AbSL, was developed to target Aβ protofibrils. A significant challenge with serum antibodies is the presence of many other biological …

Wmdds Bulletin Spring 2023

West Michigan District Dental Society Bulletin

In the Spring 2023 issue, the reader will find the following feature articles:

• ADA Dentist and Student Lobby Day
• Practice Perspective: Missional Dentist
• Dentists Doing Good

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.

Wmdds Bulletin Winter 2023

West Michigan District Dental Society Bulletin

In the Winter 2023 issue, the reader will find the following feature articles:

• Congress and the State Legislature: Is There a Difference?
• 2023 Silent Bell Recipient: Debra A. Peters, DDS
• 2023 Silent Bell Awards Night and Celebration Highlights
• Practice Perspective: My Journey into Public Health Dentistry
• Kent County Low Cost Dental Clinics

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.

Wmdds Bulletin Directory 2023

West Michigan District Dental Society Bulletin

In the 2023 WMDDS Directory issue, the reader will find a comprehensive listing of WMDDS members for 2023.

Wmdds Bulletin Summer 2023

West Michigan District Dental Society Bulletin

In the Summer 2023 issue, the reader will find the following feature articles:

• Advocacy in Action: Network Leasing
• Practice Perspective: Transitions in Dental Practice

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.

Wmdds Bulletin Holiday 2023

West Michigan District Dental Society Bulletin

In the Holiday 2023 issue, the reader will find the following feature articles:

• Advocacy in Action: What is the CGIA?
• Volunteer in Your Own Office — Join the Work of the Interfaith Dental Program
• Practice Perspective: Practice Ownership as a New Parent
• Beyond the Chair: Douglas Orzel, DDS

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.

Wmdds Bulletin Fall 2023

West Michigan District Dental Society Bulletin

In the Fall 2023 issue, the reader will find the following feature articles:

• Reflections on ADA Delegation
• Advocacy in Action: Network Leasing Part II
• Practice Perspective: Life as a Dental Student in 2023

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.

A Rare Case Of Recurrent Ocular Surface Squamous Neoplasia, Ananya Verma, Keerthan Rao

Vedam- 2024, The Academic Fest and Undergraduate Medical Conference of KMC, Manipal

No abstract provided.

Mucinous Tubular And Spindle Cell Carcinoma With Membranoproliferative Glomerulonephritis: A Case Report And Review Of Literature, Ashirbad Ota, Mary Mathew

Vedam- 2024, The Academic Fest and Undergraduate Medical Conference of KMC, Manipal

No abstract provided.

What’S Behind The Eye? A Detailed Case Analysis Of Orbital Lymphoma, Sai Sriya Yadavalli, Soumya S

Vedam- 2024, The Academic Fest and Undergraduate Medical Conference of KMC, Manipal

No abstract provided.

Hpv-Associated Branchiogenic Carcinoma: A Unique Case With Clinical Insights And Implications, Shan Rajesh, Arya Jayan

Vedam- 2024, The Academic Fest and Undergraduate Medical Conference of KMC, Manipal

No abstract provided.

Doubly Rare, Pleomorphic Adenoma Of The Submandibular Gland In A Child, Rhea Maria D’Souza, Sundeep P T, Nitin Pai

Vedam- 2024, The Academic Fest and Undergraduate Medical Conference of KMC, Manipal

No abstract provided.

A Case Study Of Rare Submandibular Gland Swelling: Spindle Cell Neoplasm, Utkarsh Raj, Krishna Prasad K, Pramodh K N, Kalyani R

Vedam- 2024, The Academic Fest and Undergraduate Medical Conference of KMC, Manipal

No abstract provided.

Heart Off-Site Making Diagnosis Right" - A Case Report On Kartagener Syndrome, Riya ., Hanumanthakari Prudhvirajrana

Vedam- 2024, The Academic Fest and Undergraduate Medical Conference of KMC, Manipal

No abstract provided.

A Diagnostic Challenge In Midbrain Lesions: Nothnagel Syndrome, Sanjith Krishna S, Lokesh M

Vedam- 2024, The Academic Fest and Undergraduate Medical Conference of KMC, Manipal

No abstract provided.

An Unusual Cause Of Stroke In A Middle Aged Female, Shines Mariya Shaji P, Krishnan Balagopal

Vedam- 2024, The Academic Fest and Undergraduate Medical Conference of KMC, Manipal

No abstract provided.