Medicine and Health Sciences Commons^™

Postoperative Conundrum: Horner Syndrome Secondary To Anterior Cervical Discectomy And Fusion Procedure, Nicholas Mynarski, Sabrina M. Johnson, Aanchal Sawhney, Christine Giesa Do, Rachel Odeyemi Do

Transformative Medicine

IntroductionHorner syndrome is a rare complication following anterior cervical discectomy and fusion (ACDF) surgeries, with an incidence rate of

Case DescriptionWe report a case of a 45-year-old female with a history of non-Hodgkin's lymphoma and chronic obstructive pulmonary disease who developed Horner syndrome post-ACDF. Initially admitted for suspected cholecystitis found on imaging following a fall, the patient's clinical course was complicated by worsening cervical and lumbar pain. This prompted MRI evaluation revealing cervical stenosis at C5-C6 and ACDF was performed without intraoperative complications. However, on postoperative day three, the patient developed left eye ptosis and miosis, consistent with …

Uncontrolled Hypertension Or A Bad Medication Interaction? The Importance Of Reviewing Over-The-Counter Medications During Medication Reconciliation, Shefali Amin Do, Caitlyn R. Moss Md

Transformative Medicine

Introduction: In the management of chronic conditions, review of the complete medication list for potential drug-drug interactions is crucial. This case involves a patient taking activated charcoal for unclear reasons, leading to misdiagnosed uncontrolled hypertension.

Case Description: We present the case of an elderly male with uncontrolled hypertension who had been placed on multiple chronic antihypertensives for years. On further review, he was found to be taking activated charcoal twice daily thereby inactivating his five oral antihypertensive medications and making his blood pressure difficult to control. Discontinuation of the activated charcoal led to significant improvement in his blood …

Relationship Of Amphetamines In Reducing Substance Abuse Risks Among Adhd Patients, Ashley Deng, Eduardo Espiridion Md

Transformative Medicine

Introduction: Attention-deficit-hyperactivity disorder (ADHD) affects a substantial portion of the global population, influencing cognitive and behavioral function. Current treatments often involve stimulant medications like amphetamines, which are controlled substances due to their addiction potential. Non-stimulant options, such as atomoxetine, are typically considered secondary therapies. This study examines the relationship between ADHD medication use and the subsequent development of psychoactive, stimulant, and cocaine-related substance use disorders. Methods: Using the TriNetX database, we conducted a retrospective cohort study to compare ADHD patients prescribed amphetamines to those receiving atomoxetine or no medication. Propensity score matching was employed to control for confounding variables, followed …

The Camden Study - A Pregnancy Cohort Study Of Pregnancy Complications And Birth Outcomes In Camden, New Jersey, Usa., Stephanie Shiau, Xinhua Chen, Ayana April-Sanders, Ellen C Francis, Shristi Rawal, Megan Hansel, Kehinde Adeyemi, Zorimar Rivera-Núñez, Emily S Barrett

Rowan-Virtua School of Osteopathic Medicine Departmental Research

BACKGROUND: Pregnancy is a unique stage of the life course characterized by trade-offs between the nutritional, immune, and metabolic needs of the mother and fetus. The Camden Study was originally initiated to examine nutritional status, growth, and birth outcomes in adolescent pregnancies and expanded to study dietary and molecular predictors of pregnancy complications and birth outcomes in young women.

METHODS: From 1985-2006, 4765 pregnant participants aged 12 years and older were recruited from Camden, NJ, one of the poorest cities in the US. The cohort reflects a population under-represented in perinatal cohort studies (45% Hispanic, 38% non-Hispanic Black, 17% White …

"Does Anyone Believe Me"?: The Traumatization Of Domestic Violence Survivors In The Criminal Justice System, Olivia Depalma

Master of Arts in Human Services

Survivors of domestic violence are often subject to chronic trauma as well as a heightened risk of injuries and mental health problems and disorders. The intention of the author is to focus on how trauma impacts a survivor’s ability to maneuver and interact with the criminal justice system (CJS). Prior studies have shown how survivor’s behaviors, usually the result of trauma, can lead to misconceived notions and beliefs in court officials and those involved in the CJS. Survivors will often face judgment, doubt, and criticism in the CJS, and this can impact their willingness to come forward, report the abuse, …

Real-World Assessment Of Listener Preference For Hearing Aid Technology Levels In Socially Involved Situations, Danielle Glista, Robin O'Hagan, Krystal Beh, Jeff Crukley, Susan Scollie, Leonard Cornelisse

Communication Sciences and Disorders Publications

Introduction: Current hearing aids have an abundance of feature options and technologies. It is important to understand the clinical impact of hearing aid technology selection and how to individualize fittings to optimize hearing aid performance according to listening environment. To probe the naturalistic listening experiences researchers can use in-situ outcome measures. Survey based real-world assessments can increase knowledge of hearing aid users’ everyday scenarios, beyond the limits of lab-based scenarios. This study aimed to assess the relationship between subjective preference ratings of adult listeners and hearing aid technology level using Ecological Momentary Assessment (EMA). A secondary research question explored survey …

The Pulse - December 19, 2024, Unm Hsc Marketing & Communications

The Pulse

Weekly newsletter of the UNM Health Sciences Center.

Novel Approach To Advance Directive Training: Hospice And Palliative Care Fellow Led Workshop Feasible And Effective In Increasing Confidence In End Of Life Conversations, Chelsea Chang, Jose Cano, Juan Lopez-Alvarenga, Josenny Rodriguez Paez, Sonya R. Montes, Rosa White, Meghana Rao

School of Medicine Publications

Despite the benefits of Advance directives, approximately only 1 in 3 U.S adults have documented advance directives. In medical school and residency, learners are often not taught or given very brief information on conducting end-of-life planning conversations with patients. Due to this deficiency, some institutions have conducted advance directive workshops but not many have been both palliative fellow and resident led, though some have been led by a geriatric fellow. Therefore, we approached advance directives with a resident and palliative fellow-led workshop. We aimed to develop and conduct a workshop on advance directives to assess feasibility and effectiveness in raising …

Cognitive Behavioral Therapy (Cbt) Interventions For Group Therapy For College Students Experiencing Depression, Ty Ogren

Dissertations, Theses, and Projects

This group manual was created to support college students struggling with a depressive mood disorder such as Major Depressive Disorder. The instance of mental health concerns, including depression, have increased greatly over the last several years. Depression is the most common mental health concern for college students, and the rate at which they experience depressive symptoms has exceeded that of the general population. Depressive symptoms in college students can lead to many concerns like poor academic achievement, self-isolation, poor diet and nutrition, and suicidal ideation (Liu et al., 2022). This group manual aims to equip college students struggling with depression …

Proteoglycan 4 (Lubricin) And Regulation Of Xanthine Oxidase In Synovial Macrophage As A Mechanism Of Controlling Synovitis, Khaled A. Elsaid, Ling X. Zhang, Thomas Zhao, Ava Marks, Derek Jenkins, Tannin A. Schmidt, Gregory D. Jay

Pharmacy Faculty Articles and Research

Background

Synovial macrophages (SMs) are important effectors of joint health and disease. A novel Cx3CR1 + TREM2 + SM population expressing the tight junction protein claudin-5, was recently discovered in synovial lining. Ablation of these SMs was associated with onset of arthritis. Proteoglycan 4 (PRG4) is a mucinous glycoprotein that fulfills lubricating and homeostatic roles in the joint. The aim of this work is to study the role of PRG4 in modulating synovitis in the context of SM homeostasis and assess the contribution of xanthine oxidase (XO)-hypoxia inducible factor alpha (HIF-1a) axis to this regulation.

Methods

We used Prg4FrtloxP/FrtloxP …

Analyzing Errors Across Nonword Repetition Tasks For Clinical Utility Among Children Who Speak African American English, Tatum Carver-Dews

LSU Master's Theses

Purpose

Within the context of African American English (AAE), this study aimed to examine the clinical utility of three different types of NWR tasks to differentiate children with Developmental Language Disorder (DLD) from those who are typically developing (TD), by percentage of phonemes correct (PPC) and by type of error (e.g., consonants or vowels; omissions or substitutions). Additionally, this study allowed for examination of the relationship between the children’s NWR performance and their density of dialect-specific forms.

Methods

The data came from 50 kindergarteners (25 females, 25 males) who had participated in a multi-year study of childhood DLD within the …

Racial And Ethnic Differences In Outcomes Of Neonates Born At Less Than 30 Weeks' Gestation, 2018-2022, Nansi S. Boghossian, Marco Geraci, Erika M. Edwards, Jeffrey D. Horbar

Faculty Publications

Importance: Previous research has examined outcomes among very preterm newborns by the birthing parent's race and ethnicity, but knowledge about these trends during the COVID-19 pandemic is limited. Objective: To examine trends in outcomes among Black, Hispanic, and Asian preterm newborns compared with White preterm newborns. Design, Setting, and Participants: This cohort study (2018-2022) took place at 774 neonatal intensive care units in the Vermont Oxford Network. Participants were newborns born at 22 to 29 weeks' gestation. Exposure: Race and ethnicity. Main Outcomes and Measures: The primary outcomes were mortality and complications, including respiratory distress syndrome, necrotizing enterocolitis (NEC), early-onset …

Assessing Tolerability With The Functional Assessment Of Cancer Therapy Item Gp5: Psychometric Evidence From Libretto-531, A Phase 3 Trial Of Selpercatinib In Medullary Thyroid Cancer, Antoine Regnault, Laurine Bunod, Angely Loubert, Marcia S. Brose, Lisa M. Hess, Patricia Maeda, Yan Lin, Rebecca M. Speck, Adrienne M. Gilligan, Nalin Payakachat

Department of Medical Oncology Faculty Papers

BACKGROUND: This psychometric analysis generated evidence to support the use of the Functional Assessment of Cancer Therapy item GP5 (GP5) as a measure of tolerability and confirms the appropriateness of categorizing "high side-effect burden" using a rating of 3 or 4 (score ranges 0-4) in patients with advanced/metastatic RET-mutant medullary thyroid cancer (MTC).

METHODOLOGY: Blinded, pooled interim data from the safety population (n=290) enrolled in the phase 3 LIBRETTO-531 trial (NCT04211337) were used. Intraclass correlation coefficients (ICC) were calculated for test-retest reliability using data from cycles 1-2 post-baseline. Construct validity was evaluated by examining the correlations of GP5 ratings with …

Assistive Technology Abandonment With Veterans And Leisure Activities, Tara Lamson, Lee Ann Hoffman, Mary Greer

Fall 2024 OTD Capstone Symposium

Veterans using assistive technology (AT) often face barriers that limit their participation in meaningful leisure activities, negatively impacting their mental health and quality of life. This project aimed to address these challenges by developing an educational program focused on improving AT management, reducing abandonment, and promoting leisure engagement. A needs assessment of veterans in Abilene, TX, revealed critical issues, including barriers to leisure, limited community involvement, and gaps in AT maintenance education. The program delivered web-based and in-person resources on AT use, adaptive leisure strategies, and equipment recycling. Key outcomes included enhanced social participation, improved independence, and sustainable solutions for …

Life Skills Program For Young Adult Males In A Transitional Living Facility, Victoria Burleson, Lesley Khan-Farooqi Phd, Otd, Otr

Fall 2024 OTD Capstone Symposium

This capstone project was created to bring awareness and provide skills to young adult males living within a transitional living facility to increase their independence, well-being and quality of life. The role of OT in transitional living facilities exists however the lack of literature allows for OT services to be expanded in non-traditional setting. This project and others similar benefit the young men to have positive outcomes and address obstacles this population faces,

To-Do List: A Chore Program For Children With Autism Spectrum Disorder, Mariah Gad, Mary Jan Greer, Danielle Howerton

Fall 2024 OTD Capstone Symposium

Many children with autism spectrum disorder do not have the exposure to age-appropriate chore tasks because their parents may be unaware of how to actively get their child involved with household tasks. The overarching goal of this project was to develop a chore program for children with autism to gain responsibilities and learn functional living skills through the use of household chores to aid in the transition process to adulthood.

Opportunities To Address Health Disparities In Suicidality For Sexual And Gender Minority Youth In Public Systems, Dana M. Prince, Kathleen Lewis, Peter S. Hovmand

Faculty Scholarship

No abstract provided.

Strengthening Tobacco Control Research: Key Factors Impacting Policy Outcomes And Health Equity, Bukola Usidame, Natalie Mcarthur, Andrea Titus

Department of Health and Kinesiology Faculty Publications

In this policy brief, we explore several potential drivers of heterogeneity in policy outcomes that can be examined in tobacco control policy evaluations, expanding the evidence base to contribute to continued, equitable progress in reducing tobacco-related health outcomes. We discuss these factors in the context of a hypothetical evaluation of the impact of smoke-free laws on current smoking and quit attempts in the Tobacco Nation. Despite a similar policy environment within the Tobacco Nation, there is variation in the strength of smoke-free law coverage across states. This commentary considers how policy design and other contextual factors, including co-occurring policies, and …

Epilepsy Therapies Symposium | Do We Really "Outgrow" Seizures?, Adam Ostendorf, Genna J Waldman, Lara Jehi, Mohammed Ilyas, Dean Naritoku, Alica M Goldman

Faculty, Staff and Students Publications

Initiation and maintenance of antiseizure therapy can be relatively straightforward in most patients. Depending on epilepsy type, patients may be more or less likely to enter remission or a resolution of their epilepsy and the International League Against Epilepsy developed clinically guiding definitions in this regard. The mechanisms by which resolution or remission are achieved are poorly understood which complicates clinical decision making and risk estimate for future seizure relapse. The impetus for the maintenance of medical therapy in a seizure-free patient is also age-dependent. In children, one ought to consider the unknown effects of antiseizure medications on the developing …

Six-Month Follow-Up Comparing Ait And Eft In The Reduction Of Negative Emotions Associated With A Past Memory, Gregory Brown, Kavita Batra, Emily Dorin, Andrew Han, Arianna Palermini, Robert Sottile, Sherine Khanbijian

Psychiatry & Behavioral Health Faculty Research

Statistics have shown that about sixty percent of individuals with psychiatric illness do not respond adequately to standard treatments, yet only 1% of research studies are focused on developing new therapeutic strategies for these patients (McIntyre et al., 2023). This study investigated the long-term efficacy of Advanced Integrative Therapy (AIT) as compared to Emotional Freedom Techniques (EFT), specifically evaluating the durability of the resolution of emotional distress tied to a single memory six months post-treatment. The study began with 72 participants: and 51 completed a follow-up survey, resulting in a response rate of 70.8%. The sample was predominantly female (65%), …

Health Equity Innovation In Precision Medicine: Data Stewardship And Agency To Expand Representation In Clinicogenomics, Patrick J Silva, Vasiliki Rahimzadeh, Reid Powell, Junaid Husain, Scott Grossman, Adam Hansen, Jennifer Hinkel, Rafael Rosengarten, Marcia G Ory, Kenneth S Ramos

Center for Medical Ethics and Health Policy Staff Publications

Most forms of clinical research examine a very minute cross section of the patient journey. Much of the knowledge and evidence base driving current genomic medicine practice entails blind spots arising from underrepresentation and lack of research participation in clinicogenomic databases. The flaws are perpetuated in AI models and clinical practice guidelines that reflect the lack of diversity in data being used. Participation in clinical research and biobanks is impeded in many populations due to a variety of factors that include knowledge, trust, healthcare access, administrative barriers, and technology gaps. A recent symposium brought industry, clinical, and research participants in …

Il-12 Encoding Ondv Synergizes With Car-T Cells In Orthotopic Models Of Non-Small Cell Lung Cancer, Amanda Rosewell Shaw, Daisuke Morita, Caroline E Porter, Eric Tu, Greyson W Biegert, Sonia Agrawal, Nicholas Durham, Malcolm K Brenner, Masataka Suzuki

Faculty, Staff and Students Publications

Systemic administration of oncolytic viruses (OVs) is a promising approach for targeting metastatic solid tumors, but their anti-tumor activity is limited by pre-existing neutralizing antibodies against common human viruses. Therefore, investigators have developed OVs derived from non-human host viruses. Successful implementation of this strategy requires that the viral vector selectively infects and replicates within human cancer cells. Newcastle disease virus (NDV) is an avian paramyxovirus that, as NDV-based OVs (oNDVs), has demonstrated safety and activity against multiple human tumors in clinical trials. Their use as a single agent, however, is insufficient to cure tumors. Similarly, chimeric antigen receptor-modified T cells …

Implementation Strategies To Improve Medication Adherence In Adolescents (Aged 13 To 17 Years) With Antipsychotic Induced Weight Gain: Educational Toolkit For Clinicians, Joy Asike

Doctoral Dissertations and Projects

Nonadherence to medication leads to relapses of condition, frequent hospitalization and poor outcomes. Although antipsychotics are effective in the management of mental disorders and psychosis, the side effects, especially weight gain negatively influence medication compliance. Anti-psychotics related to weight gain is one of the most concerning treatment-emergent side leading to a great burden on patients, parents, and clinicians. Obesity and antipsychotic-related weight gain increase the risks to short- and long-term physical health problems such as metabolic syndrome, dyslipidemia, diabetes, hypertension. Evidence has shown that there is generally low guideline adherence regarding the monitoring of antipsychotics, especially in children and adolescents. …

A Quantitative Approach To Determining The Reduction Rate Of Cassette Labeling Errors Within A Surgical Pathology Diagnostic Laboratory, Kiaya Symonné Pruitt

Doctoral Dissertations and Projects

Cassette labeling errors within a surgical pathology laboratory can affect patient safety variously, including invalid patient results. In order to diminish these errors, automated systems have been placed in surgical pathology laboratories. However, there is no current research on reducing cassette labeling errors within a surgical pathology laboratory that possesses a partial automated system without a LIS connection. Therefore, the current study aimed to determine if there is a statistically significant reduction in pathology cassette labeling errors during different phases of the barcode system (an automated system) implementation for cassette creation. A nonexperimental correlational design was used for the current …

Implementing A Patient Decision Aid Tool To Improve Knowledge Of Lung Cancer Screening And Lung Cancer Screening Rates In A Primary Care Setting, Emily Evans Brown

Doctoral Dissertations and Projects

It is well known that lung cancer is a devastating disease affecting many individuals in the United States. Through education and early screening efforts, lung cancers can be identified earlier when they can be more easily treated. This evidence-based practice project was developed for the purpose of improving patient and provider knowledge of lung cancer screening and to increase lung cancer screenings in primary care. The evidence-based lung cancer screening educational tool, referred to as a patient decision aid tool, was implemented in a family medicine practice setting over a 10-week period. After the 10-week implementation, there was an increase …

The Role Of Camaraderie In The Moods Of African American U.S. Military Veterans With Ptsd: A Qualitative Phenomenological Study, Virginia K. Thompson

Doctoral Dissertations and Projects

The purpose of this qualitative phenomenological study was to understand the essence of the collective lived experiences of United States military veterans of African American ethnicity who were diagnosed with posttraumatic stress disorder (PTSD) and the role that camaraderie plays in their moods. Veterans are a marginalized group who often feel they are rejected by society, but as Christians, we should be interested in human beings, promoting their well-being, and practicing psychology as an act of love. Guided by social identity theory and social justice theory, this study was aimed to gain understanding of how group memberships and social categorization …

Accessing Cancer Care Through A Community Diagnostic Clinic, Joy Lynn Bartholomew

Doctoral Dissertations and Projects

Access to diagnostic centers, innovative cancer research and best clinical practices is limited outside metropolitan areas and academic institutions. Cancer patients in rural communities are a marginalized population faced with unique barriers to high quality care from early detection through screening, streamlined diagnostics, and participation in clinical trials. One-stop clinics (OSC) in the community setting may lessen the diagnostic interval (DI), reduce the economic burden of unnecessary imagining or procedures, minimize sociodemographic discrepancies, and positively affect time to treatment and clinical trial participation. The first step is to better understand the community cancer population and their diagnostic journey. Next, an …

Pancreaticoduodenectomy In Trauma Patients With Grade Iv-V Duodenal Or Pancreatic Injuries: A Post Hoc Analysis Of An East Multicenter Trial, Rachel Leah Choron, Charoo Piplani, Julia Kuzinar, Amanda L. Teichman, Christopher Bargoud, Jason D. Sciarretta, Randi N. Smith, Dustin Hanos, Iman N. Afif, Jessica H. Beard, Navpreet Kaur Dhillon, Ashling Zhang, Mira Ghneim, Rebekah Devasahayam, Oliver Gunter, Alison A. Smith, Brandi Sun, Chloe S. Cao, Jessica K. Reynolds, Lauren A. Hilt, Daniel N. Holena, Grace Chang, Meghan Jonikas, Karla Echeverria-Rosario, Nathaniel S. Fung, Aaron Anderson, Caitlin A. Fitzgerald, Ryan Peter Dumas, Jeremy H. Levin, Et Al

School of Medicine Faculty Publications

INTRODUCTION: The utility of pancreaticoduodenectomy (PD) for high-grade traumatic injuries remains unclear and data surrounding its use are limited. We hypothesized that PD does not result in improved outcomes when compared with non-PD surgical management of grade IV-V pancreaticoduodenal injuries. METHODS: This is a retrospective, multicenter analysis from 35 level 1 trauma centers from January 2010 to December 2020. Included patients were ≥ 15 years of age with the American Association for the Surgery of Trauma grade IV-V duodenal and/or pancreatic injuries. The study compared operative repair strategy: PD versus non-PD. RESULTS: The sample (n=95) was young (26 years), male …

Factors Associated With Cognitive Flexibility In People With Opioid-Use Disorder: A Pilot Study, Paul S. Regier, Thais Costa Macedo De Arruda, Laura Sinko, Anne M. Teitelman, Anna Rose Childress

College of Nursing Faculty Papers & Presentations

The ability to adapt to changing circumstances has strong survival value. Individuals with substance use disorders tend to get "stuck" over-responding to drug-reward signals and pursuing drugs despite negative consequences. A lack of flexibility may be tied to impairments in neurocognition, including learning, memory, and executive function. However, results are often mixed, potentially due to heterogeneity in factors such as mental health, personality traits, or prior adversity. This study aimed to identify which factors influence neurocognitive variations within the opioid use disorder (OUD) population. Based on prior literature, we hypothesized that individuals with OUD would show deficits (vs. controls) in …

Author Correction: Single-Cell And Spatial Proteo-Transcriptomic Profiling Reveals Immune Infiltration Heterogeneity Associated With Neuroendocrine Features In Small Cell Lung Cancer, Ying Jin, Yuefeng Wu, Alexandre Reuben, Liang Zhu, Carl M Gay, Qingzhe Wu, Xintong Zhou, Haomin Mo, Qi Zheng, Junyu Ren, Zhaoyuan Fang, Teng Peng, Nan Wang, Liang Ma, Lungevity Panshi Initiative Consortium, Yun Fan, Hai Song, Jianjun Zhang, Ming Chen

Faculty, Staff and Student Publications

No abstract provided.