Medicine and Health Sciences Commons^™

Effect Of Modified Smart Extender On Sperm Longevity And Frozen-Thawed Semen Quality In Bantam Chicken (Gallus Gallus), Nattaporn Chaysakul, Naruephon Leeamnuaycharoen, Marvin Bryan Salinas, Teepakorn Lertwichaikul, Chakorn Kunkaew, Jureerat Sumretprasong, Anucha Sathanawongs

The Thai Journal of Veterinary Medicine

The round body shape and short legs of Bantam chickens (Gallus gallus) pose breeding challenges, making artificial insemination critical for these animals. To contribute to such assisted reproductive technology in avians, this study assessed the effect of a modified simple medium for assisted reproductive technology (SMART) extender on sperm longevity and frozen-thawed semen quality compared to the Blumberger Hahnen Sperma Verdünner (BHSV) extender. Sperm motility and viability were measured in 20 roosters at fresh and chilled conditions at 4-, 24-, and 48-hour intervals. For the subsequent freezing step, 6% and 9% DMA were added to both extenders as …

Morphological And Morphometric Variations Of The Tympanic Bulla Between Domestic Shorthair And Brachycephalic Cats Utilizing Computed Tomography, Naparee Srisowanna, Damri Darawiroj, Nan Choisunirachon, Chutimon Thanaboonnipat, Sirinun Pisamai Tabtieang

The Thai Journal of Veterinary Medicine

Tympanic morphology of the dogs was reported to be varied due to the characteristics of the skull types. The small tympanic bulla is normally seen in brachycephalic dogs. However, this variation in narrowed-skull shaped cats has not been unveiled yet. The objective of this study was to describe the tympanic morphology of cats between brachycephalic and domestic shorthair (DSH) cats. Computer tomography (CT)-skull images of 15 domestic shorthair cats and 11 brachycephalic cats were evaluated for tympanic dimension on transverse and dorsal planes and the tympanic bone thickness. All parameters were compared between both groups. The results revealed that all …

Research Progress On The Structure And Function Of The Main Glycoproteins Of Bovine Infectious Rhinotracheitis Virus, Xin Zhang, Ruizhen Jian, Weijuan Jia, Yunjiao Chen, Qinglei Meng, Fang Yang, Jianjian Han, Zhilin Liu, Zelin Jia, Jiayu Cui, Xueli Wang

The Thai Journal of Veterinary Medicine

Infectious bovine rhinotracheitis (IBR) is an acute, febrile, and contact infectious disease. Bovine infectious rhinotracheitis is endemic in China and even the world, which not only restricts the development of the cattle industry but also brings significant economic losses to farms. Infectious bovine rhinotracheitis virus (IBRV) contains 25 - 33 structural proteins, of which glycoproteins gB, gC, gD, gE, gG, gH, gI, gK, gL, and gM are the major structural glycoproteins of bovine rhinotracheitis virus, and all of these glycoproteins are interconnected with the assembly, invasion, release, and replication of the virus, and the only glycoproteins that are known …

A Systematic Literature Review Of Granulocytes-Colony Stimulating Factor Treatment In Animals, Syahirah Ahmad Affandi, Nurul Hayah Khairuddin, Mohammed Sadiq Babatunde, Azalea Hani Othman, Collin Looi Seng Kim, Siti Sarah Othman, Sharifah Roohi Syed Waseem Ahmad

The Thai Journal of Veterinary Medicine

This study presents a systematic literature review (SLR) on the efficacy of granulocytes-colony stimulating factor (G-CSF) as a treatment component in relation to clinicopathological parameters and overall outcomes. Using the PICO approach, a research question development tool, the SLR was designed to identify the animals in which G-CSF had been used, the types of G-CSF utilized and their effectiveness as a therapeutic agent in stimulating haematological parameters, as well as their potential adverse effects. Three primary keywords associated with the review topic were selected and incorporated into the search query to retrieve pertinent literature from three databases: Scopus, Science Direct, …

Challenges And Barriers Faced By Healthcare Workers In Implementing Strategies To Reduce Teenage Pregnancy In Iligan City, Elise Janella A. Denila, Jydel Anne P. Dalangin, Wynne Nicole P. Englatiera, Dave William E. Almonia, Ian C. Abordo, Donna Belle P. Sumugat Rn, Man, Raymond M. Salvador

Pacific Journal of Health

Aims: To investigate nursing strategies and their perceived barriers in reducing teenage pregnancy among barangays in Iligan City with high incidence of teenage pregnancy.

Study Design: This study uses qualitative, exploratory research design. This design is ideal for delving into complex issues and understanding phenomena in their real-world context.

Place and Duration of the Study: Iligan City Philippines, between September 2023 and May 2024

Methods: This study includes 6 healthcare workers experienced in handling teenage pregnancy and 25 teenagers who have experienced it. Participants were selected using purposive sampling to ensure they had relevant experiences. Data was collected through face-to-face, …

Impact Of County-Level Urbanicity On Quality Of Life For People With Intellectual And Developmental Disabilities In A Rural State., Alyssa M. Smith, Allison Caudill

Developmental Disabilities Network Journal

People with intellectual and developmental disabilities (IDD) face challenges, such as decreased access to physical, environmental, and social health-related services that can negatively impact their overall quality of life (QoL). Additionally, people living in rural communities may experience geographic distancing and other factors, like decreased transportation and available housing, that contribute to increased isolation and decreased health outcomes, overall. It is important to consider the QoL of people with IDD living in these communities given the additional intersectional constraints of rurality and having an intellectual disability or other co-occurring conditions. A secondary data analysis reviewed closed and open-ended survey data …

Impact Of A Narrative Language Intervention On Language, Behavior, And Self-Concept Among Bilingual Children With Developmental Language Disorder, Nancy Tarshis Ma, Ms, Ccc-Slp, Kathleen Mcgrath Mss, Lsw, Ida Barresi Ma, Ccc-Slp, Risa Battino Ms, Ccc-Slp, Bcs-F, Sarah Henderson Msed, Ms, Ccc-Slp, Shankar Viswanathan Drph, Jee-Young Moon Phd, Karen Bonuck Phd

Developmental Disabilities Network Journal

The growing research on narrative interventions is promising but has gaps regarding cultural/linguistic diversity and outcomes beyond language. We evaluated whether a structured, oral narrative intervention affects narrative language, problem behaviors, and self-concept in a diverse group of children with developmental language disorder. A 10-session intervention was implemented within routine care. Baseline and follow-up data included: (a) Narrative recordings—coded by therapists using the CUBED Narrative Language Measure, (b) Child Behavior Checklist—a parent-reported behavioral assessment, and (c) the Piers-Harris Children’s Self-Concept Scale. Among the sample’s n = 33 children, aged 6-16, 55.6% were bilingual. Post intervention, participants’ narrative language scores improved …

Disability Education In Medical Schools: A Paradigm Shift For Inclusive Care, Hannah Ship Md, Mph, Sahana Shankar M.D., Rochelle Baer Lcsw, Jeffrey Brosco M.D., Ph.D., Jairo Arana, Damian Gregory, Robert Irwin M.D., Gauri Agarwal M.D., Sabrina Taldone Md, Mba, Sheryl Eisenberg Michalowski Ma, Daniel Quintero M.D., Anna Shah M.D., Frank Woo M.D., Michelle Schladant Ph.D., Ashley Falcon Phd, Mph

Developmental Disabilities Network Journal

Disability education for medical students is often insufficient and can contribute to health disparities for people with disabilities. Our interdisciplinary curriculum development team created a longitudinal 4-year disability education model aimed at improving patient care for people with disabilities. Central to our curriculum are progressive sessions aligned with students' medical journey, including three required sessions covering interdisciplinary healthcare teams, implicit bias, health disparities, disability culture, shared decision-making, communication, and self-determination. Through the inclusion of people with disabilities, an interdisciplinary curriculum development team, and trainee-driven advocacy, our longitudinal multi-phasic disability education curriculum seeks to mitigate health disparities. Our innovative approach addresses …

Applying A Framework Of Epistemic Injustice To Understand The Impact Of Covid-19 On People With Intellectual And Developmental Disabilities, Sarah Lineberry, Matthew Bogenschutz

Developmental Disabilities Network Journal

Epistemic injustice, the theory of unfairness related to knowledge, is a useful framework for understanding the ways in which historic and ongoing marginalization and stereotypes have shaped the ways that people with intellectual and developmental disabilities (IDD) have been impacted by the COVID-19 pandemic. We conducted a scoping review of the literature and divided findings into physical health (cases, hospitalization, and death) and psychosocial outcomes (access to services, mental health symptoms, community participation, etc.). Impacts were then analyzed using the key principles of epistemic injustice. Findings suggest that people with intellectual and developmental disabilities (IDD) experienced high rates of negative …

Barriers To Health Care Among Adults With Disabilities In Connecticut, Mary Beth Bruder Phd, Tara M. Lutz Phd, Kelly E. Ferreira Phd

Developmental Disabilities Network Journal

It is estimated that 25% of adults in the US are living with one or more disabilities. Persons with disabilities (PWD) have unmet health care needs, experience health disparities compared to those without disabilities. Barriers to quality health care include structural barriers such as access to transportation, physical access to facilities, and lack of accessible medical equipment. Other barriers include the knowledge, skills, beliefs, and attitudes of health care providers to meet the needs of PWD. To examine the barriers to health care experienced by adults with disabilities in Connecticut, the University of Connecticut Center for Excellence in Developmental Disabilities …

Consensus Of The National Heart Center In Collaboration With The Saudi Arabian Cardiac Interventional Society On The Clinical Use Of Intracoronary Imaging, Mirvat Alasnag, Mognee Alameer, Ahmed Alshehri, Hind Alosaimi, Faisal Alqoofi, Hussain Alzayer, Wail Alkashkari, Adel Tash, Waqar H Ahmed

Journal of the Saudi Heart Association

Objectives: Studies show that intracoronary imaging (ICI)-guided PCI is associated with a significantly lower risk of stroke, Q-wave myocardial infarction, and death compared to angiography-guided PCI in the management of acute coronary syndromes, complex coronary lesions and left-main interventions. Despite these well-established clinical benefits, the utilization of ICI-guided PCI in Saudi Arabia remains suboptimal.

Methods: The National Heart Center (NHC) and the Saudi Arabian Cardiac Interventional Society (SACIS) gathered national experts to develop a consensus document on how to integrate ICI-guided PCI in routine clinical practice in Saudi Arabia. The consensus was based on the nominal group technique, whereby a …

Outcomes In Dogs Undergoing Surgical Correction For Septic Peritonitis: A Retrospective Study In 61 Cases (2019-2022), Krishaporn Kradangnga, Naipaporn Kongrattanachat, Wichulada Suwansukroj, Jiraporn Supasombatolan, Chayanon Tiaraksa

The Thai Journal of Veterinary Medicine

This retrospective study described clinical parameters, evaluated the chance of death (hazard ratio) and compared outcomes until hospital discharge in septic peritonitis dogs that underwent surgery in 61 cases at a single academic referral hospital population. The surgical records of 223 dogs with suspected septic peritonitis requiring surgical intervention were reviewed and a total of 61 dogs, primarily mixed breed (34.43%), with intraoperative gross lesions and cytology confirmed septic peritonitis were included in the study. The gastrointestinal tract was the most common source of septic peritonitis (52.46%). The overall survival to hospital discharge was 52.46%. Admission time until surgery, drain …

Novel Cyclic Homogeneous Oscillation Detection Method For High Accuracy And Specific Characterization Of Neural Dynamics, Hohyun Cho, Markus Adamek, Jon T Willie, Peter Brunner

2020-Current year OA Pubs

Determining the presence and frequency of neural oscillations is essential to understanding dynamic brain function. Traditional methods that detect peaks over 1/

Treatment Of Acute Myeloid Leukemia In The Community Setting, Taha Al-Juhaishi, Servillano Dela Cruz, Rohan Gupta, Gina Keiffer, Vicki Morrison, Iuliana Shapira, Ashley Woods, Kelly Norsworthy, Romeo Angelo De Claro, Marc Theoret, Ravin Garg, Elizabeth Dianne Pulte

Kimmel Cancer Center Faculty Papers

The treatment landscape for acute myeloid leukemia (AML) is rapidly changing. Many new agents and lower-intensity regimens have been approved and can be safely used by hematologists and oncologists in both academic and community settings. The US Food and Drug Administration (FDA) held a virtual symposium on AML treatment in the community in November 2022. Several members of the FDA, along with practicing hematologists and oncologists in both academic and community settings, participated in the symposium. The goal of the symposium was to discuss challenges and opportunities in the treatment of patients with AML in community oncology settings. A summary …

Exploring The Use Of Bimodal Transcranial Direct Current Stimulation To Enhance Movement In Individuals With Patellofemoral Pain—A Sham-Controlled Double Blinded Pilot Study, Kai-Yu Ho, Connan Wallace, Jeno Aquino, Bryce Broadwell, Makenzie Whimple, Jing Nong Liang

Physical Therapy Faculty Publications

Introduction: In individuals with patellofemoral pain (PFP), addressing increased knee valgus during weight-bearing activities typically involves strengthening weak hip muscles. However, recent literature highlights the role of altered descending central control in abnormal movements associated with PFP. While transcranial direct current stimulation (tDCS) has demonstrated the capacity to enhance neuroplasticity, its application targeting the corticomotor function of gluteal muscles in PFP remains unexplored. This study aimed to investigate the effects of combining bimodal tDCS with exercise on frontal plane kinematics in individuals with PFP. The hypothesis was that bimodal tDCS, specifically targeting the corticomotor function of the gluteal muscles, would …

Evaluation For Mothers' Knowledge Of Childhood Tonsillitis, Ali Tahssen Alwan, Shukiryia Shadhan Chyad, Sahira Ayyed Abdul-Sahib

Maaen Journal for Medical Sciences

Background: the inflammation of the tonsils is known as Tonsillitis; it is a well-known clinical condition that an infection of either virus or bacteria. It significantly affects children especially.

The aim of the present study was to identify knowledge of mother toward childhood tonsillitis and to find the relationship between mothers' knowledge of childhood of tonsillitis and some variables.

Methods: A cross section study design was adopted in order to achieve the objectives of study. data collection began from 17th September 2023 until 30th January 2024. A non-probability convenience sample of 160 mothers were recruited to the study. …

Using Clear Aligners To Correct Severe Unilateral Lower Premolar Tilting By Lower Arch Expansion, Yu-Chen Cheng, Huei-Mei Tsai, Yi-Min Liu, Tzu-Wen Su, Yu-Ling Cheng

Taiwanese Journal of Orthodontics

This case report describes the treatment of a young female adult presenting with a moderate mandibular overgrowth relative to the maxilla. Accompanying malocclusion included procumbent upper anterior teeth, deep overbite, a complete buccal crossbite at the upper left molar, and tilted lower right premolar. The upper dental arch exhibited a tapered form, the lingually blocked-out premolar contributed to a collapsed alveolar ridge. The patient was treated with clear aligners instead of fixed appliances.

Correct The Skeletal Class Iii Malocclusion With Severe Dental Compensation And Lateral Open Bite By Indirect Use Of Maxillary Tads, Jui-Hsien Yang, Jane Kuo, Fu-Hui Tsai, Yun-Yun Wu

Taiwanese Journal of Orthodontics

The case reports a young woman with skeletal Class III (ANB= −0.5°) who was successfully treated with camouflage orthodontics even she already had severe dental compensation. A nonsurgical approach was adopted because of patient and parental concerns regarding surgical risk. Bilateral maxillary temporary anchorage devices (TADs) were inserted at the infrazygomatic crest, and Class III elastics were used to connect the bilateral lower arch canines to the miniscrews during arch leveling. The treatment resulted in a Class I molar relationship and a +3.0 mm overbite and improved the skeletal Class III relationship (ANB =+2.0°); with notable success in lower arch …

Improved Super-Elastic Ti-Ni Alloy Wire For The Treatment Of Angle Class Ii Malocclusion Combined With 3 Lower Incisors And Scissors Bite Case, Yu-Hsiang Chang, Yuan-Hou Chen, Tzu-Hsin Lee, Yu-Cheng Lo, Jian-Hong Yu

Taiwanese Journal of Orthodontics

A 16-year-old male adolescent came to our orthodontic clinic with a chief complaint of poor dental alignment. Clinical examination revealed Angle Class II malocclusion with tooth #12 blocked-in and tooth #41 congenital missing. Large anterior overjet and posterior buccal crossbite between #17 and #47 were also noted. Cephalometric analysis indicated a low mandibular plane angle. To acquire a harmonious arch coordination and to relieve anterior crowding, teeth #14 and #24 were extracted. Mechanism involved intermaxillary elastics for a better intercuspal interdigitation, mechanical stress for tooth #12 alignment, and vertical offset to eliminate antagonistic interference for easy correction of scissors bite. …

Timing Of Orthodontic Treatment (Part I), Ib Leth Nielsen

Taiwanese Journal of Orthodontics

The need and demand for orthodontic treatment has been studied in many countries around the world. Much of the discussion of this topic has centered around who should receive treatment and at what age. The examinations of school children have mostly been done by orthodontists with assistance from residents and outcomes have varied from country to country. In this review we will look at some of these studies and their findings to get a better idea of the size of the problem and what criteria have been used. Much has been said and written about the timing and in recent …

Relationship Between Posterior Cranial Base Inclination And Skeletal Jaw Patterns, Ratna Sugiartati Arif, Maria Purbiati, Krisnawati E. Tarman

Taiwanese Journal of Orthodontics

Introduction: Variations in nasion (N) could influence the measurement of ANB, thus affecting the interpretation of skeletal jaw relationship. Points sella (S) and N represent the anterior cranial base, a crucial role in determining the skeletal jaw patterns. Improper S-N line can affect results of lateral cephalometric analysis, as a highly tilted S-N line relative to the Frankfort Horizontal Plane (FHP) can lead to discrepancies between the analysis results and true morphology. Therefore, alternative methods, such as analysing the posterior cranial base (sella to basion, S-Ba), are needed to establish a diagnosis.

Objective: To determine relationship between posterior …

Strength And Conditioning Habits Of Polish Amateur Endurance Runners, Zbigniew Jost, Maciej Chroboczek

Baltic Journal of Health and Physical Activity

Introduction: Correctly performed Strength & Conditioning (S&C) training is important in terms of improving sports performance. This survey was to check S&C habits among amateur runners in Poland. Materials and Methods: The questionnaire dealt with 1) personal and anthropometric data, 2) advancement / fitness level and 3) training habits, which was correctly filled in by 923 people. The participants were matched to five fitness levels (LG1–LG5) depending on sex (W/M) and the selected distance (5K/10K/Half-Marathon). Results: More than half of the respondents (n = 467, 50.6%) considered S&C as very important. The most frequently used S&C activities were uphill runs …

The Effect Of 6-Week Eeg-Biofeedback Training In Normobaric Hypoxia And Normoxia Conditions On Reaction Time In Elite Judo Athletes, Magdalena Prończuk, Joanna Motowidło, Ewelina Lulińska, Dariusz T. Skalski, Jarosław Markowski, Jan Pilch, Maciej Kostrzewa, Artur Terbalyan, Karol Skotniczny, Adam Maszczyk

Baltic Journal of Health and Physical Activity

Introduction: The purpose of this study was to evaluate the effect of Biofeedback Training in normoxic and normobaric hypoxic conditions on reaction times in judo athletes. Material and methods: The participants in the experimental group underwent thetha/beta1 training under simulated hypoxic conditions in a laboratory equipped with a normobaric hypoxia generation system (LOS-HYP1/3NU, Lowoxygen Systems, Germany), at a simulated altitude of 2500m above sea level (FiO₂ = 15.5%). Each cycle of the study consisted of 15 training sessions. The training sessions lasted for 20 minutes, with 4 sets of 4 minutes each and a 1-minute break in between. In …

The Scaffolding Function Of Lsd1 Controls Dna Methylation In Mouse Escs, Sandhya Malla, Kanchan Kumari, Carlos A García-Prieto, Jonatan Caroli, Anna Nordin, Trinh T T Phan, Devi Prasad Bhattarai, Carlos Martinez-Gamero, Eshagh Dorafshan, Stephanie Stransky, Damiana Álvarez-Errico, Paulina Avovome Saiki, Weiyi Lai, Cong Lyu, Ludvig Lizana, Jonathan D Gilthorpe, Hailin Wang, Simone Sidoli, Andre Mateus, Dung-Fang Lee, Claudio Cantù, Manel Esteller, Andrea Mattevi, Angel-Carlos Roman, Francesca Aguilo

Student and Faculty Publications

Lysine-specific histone demethylase 1 (LSD1), which demethylates mono- or di- methylated histone H3 on lysine 4 (H3K4me1/2), is essential for early embryogenesis and development. Here we show that LSD1 is dispensable for mouse embryonic stem cell (ESC) self-renewal but is required for mouse ESC growth and differentiation. Reintroduction of a catalytically-impaired LSD1 (LSD1MUT) recovers the proliferation capability of mouse ESCs, yet the enzymatic activity of LSD1 is essential to ensure proper differentiation. Indeed, increased H3K4me1 in Lsd1 knockout (KO) mouse ESCs does not lead to major changes in global gene expression programs related to stemness. However, ablation of LSD1 but …

Targeting Igf2 To Reprogram The Tumor Microenvironment For Enhanced Viro-Immunotherapy, Min Hye Noh, Jin Muk Kang, Alexandra A Miller, Grace Nguyen, Minxin Huang, Ji Seon Shim, Alberto J Bueso-Perez, Sara A Murphy, Kimberly A Rivera-Caraballo, Yoshihiro Otani, Eunju Kim, Seung-Hee Yoo, Yuanqing Yan, Yeshavanth Banasavadi-Siddegowda, Hiroshi Nakashima, E Antonio Chiocca, Balveen Kaur, Zhongming Zhao, Tae Jin Lee, Ji Young Yoo

Student and Faculty Publications

BACKGROUND: The FDA approval of oncolytic herpes simplex-1 virus (oHSV) therapy underscores its therapeutic promise and safety as a cancer immunotherapy. Despite this promise, the current efficacy of oHSV is significantly limited to a small subset of patients largely due to the resistance in tumor and tumor microenvironment (TME).

METHODS: RNA sequencing (RNA-Seq) was used to identify molecular targets of oHSV resistance. Intracranial human and murine glioma or breast cancer brain metastasis (BCBM) tumor-bearing mouse models were employed to elucidate the mechanism underlying oHSV therapy-induced resistance.

RESULTS: Transcriptome analysis identified IGF2 as one of the top-secreted proteins following oHSV treatment. …

How Does Your Garden Grow? Development Of A Calculator To Evaluate The Economic And Dietary Impact Of Edible Gardens, Sofia O. Sanchez, Katie Funderburk, Erin Reznicek, Sondra M. Parmer

The Journal of Extension

Edible gardens can increase fruit and vegetable availability and access. Weighing produce is a method to evaluate gardens, however there are limited methods that translate garden yields to dietary yields and that document Supplemental Nutrition Assistance Program – Education (SNAP-Ed) garden yields. We developed a Garden Harvest Calculator to evaluate edible garden economic and dietary impact. Over three spring-to-summer growing seasons, 12 – 18 gardens produced 6,499 pounds of produce worth $11,606.95. This equates to 24,922 cups, enough for 4,984 adults to meet dietary recommendations. SNAP-Ed supported gardens may positively contribute to dietary needs while reducing barriers to food access.

The Effects Of An Abdominal Vibration Stimulation Program On The Quality Of Bowel Preparation In Patients Undergoing Screening And Surveillance Colonoscopy: A General Surgeons Blinded, Randomised Controlled Trial, Waraporn Sansaard, Usavadee Asdornwised, Rattima Sirihorachai, Varut Lohsiriwat

Journal of Perioperative Nursing

Background: Effective colonoscopy is considered accurate and safe when there is good quality bowel preparation. In this study, we aimed to evaluate the effectiveness of an abdominal vibration stimulation program on the quality of bowel preparation in patients undergoing screening and surveillance colonoscopy.

Design: This study was a single-centre, randomised, controlled trial.

Methods: The participants consisted of 72 patients who received elective in-patient screening and surveillance colonoscopy at a tertiary hospital in central Thailand. Patients were randomly assigned to two groups: an experimental group (n=38) and a control group (n=34). Both groups received the same bowel cleansing regimen of 90 …

Efficacy Of Parp Inhibitor Therapy After Targeted Braf/Mek Failure In Advanced Melanoma, Jordan Phillipps, George Nassief, Renee Morecroft, Tolulope Adeyelu, Andrew Elliott, Farah Abdulla, Ari Vanderwalde, Soo Park, Omar Butt, Alice Zhou, George Ansstas

2020-Current year OA Pubs

Modern advancements in targeted therapy and immunotherapy have significantly improved survival outcomes for advanced melanoma; however, there remains a need for novel approaches to overcome disease progression and treatment resistance. In recent years, PARPi therapy has shown great promise both as a single regimen and in combination with other therapeutics in melanoma. Here, we describe three unique cases of advanced BRAF V600 mutated melanoma that progressed on targeted BRAF/MEK agents that subsequently exhibited partial to near-complete responses to combinatory PARPi and BRAF/MEK inhibitors. This highlights both a potential synergy underlying this combinatory approach and its efficacy as a treatment option …

The Psychological And Social Experiences Of Hospitalised Covid-19 Patients: A Qualitative Study, Fatma Kantaş Yılmaz, Zeynep Koca, Zuhal Kunduracılar

Makara Human Behavior Studies in Asia

Individuals infected with COVID-19 have experienced torrents of problems associated with the pandemic, impairing their health, mental, social and economic conditions. The study aims to determine the psychological reactions and emotions of infected patients and the social consequences during hospitalization for COVID-19. The current study used a qualitative and phenomenological design at a Training and Research Hospital in Istanbul/Turkey. The study sample included 17 patients (41.6 ± 16.5 years) who had been discharged after treatment for COVID-19. The information gathered was classified into two main domains (social and psychological) and relevant themes and subthemes using a content analysis and classification …

Taste Masked Of Eplerenone Using Egg Box Method, Asmaa Mohammed Rashid

Maaen Journal for Medical Sciences

Eplerenone is a selective mineralocorticoid receptor antagonist employed to manage hypertension, central serous retinopathy, and chronic heart failure. It has a highly bitter taste, which reduces patient compliance with the drug.

The aim of this study was masking the very bitter taste of the eplerenone to improve patient compliance especially for geriatric patient.

The medication was encapsulated utilizing the ionic gelation process, in which a 1% w/w sodium alginate solution was utilized to form egg box structures.Two different concentrations of CaCl2 (0.5.1%w/v) were used as cross-linkers, and different drug: polymer ratios were tested. The formulas were evaluated based on their …