Comparing Methods For Risk Prediction Of Multicategory Outcomes: Dichotomized Logistic Regression Vs. Multinomial Logit Regression, Lei Li, Matthew A Rysavy, Georgiy Bobashev, Abhik Das

Faculty, Staff and Student Publications

Background: Medical outcomes of interest to clinicians may have multiple categories. Researchers face several options for risk prediction of such outcomes, including dichotomized logistic regression and multinomial logit regression modeling. We aimed to compare these methods and provide guidance needed for practice.

Methods: We described dichotomized logistic regression, multinomial continuation-ratio logit regression, which is an alternative to standard multinomial logit regression for ordinal outcomes, and logistic competing risks regression. We then applied these methods to develop prediction models of survival and neurodevelopmental outcomes based on the NICHD Extremely Preterm Birth Outcome Tool model. The statistical and practical advantages and flaws …

Findings From The Mighty Girls Efficacy Trial: Changes In Acceptance Of Dating Violence., Michael L Hecht, Anne E Norris, Daniel Max Crowley, Jeff R Temple, Hye Jeong Choi

Faculty, Staff and Student Publications

Background/objectives: Test efficacy of the social emotional learning (SEL)-based Mighty Girls program, a program culturally tailored for English-speaking Hispanic/Latino girls in seventh grade comprised of classroom sessions and a virtual reality computer game. We hypothesized that the curriculum would decrease risky sexual behaviors in a program that can be used as part of a comprehensive sex education curriculum or as a stand-alone program.

Methods: A randomized group trial was conducted in which 22 low-income, predominately Hispanic schools within the Miami-Dade County Public School System were randomly assigned to intervention (consented n = 335) and control (consented n = 217) conditions. …

Hubungan Tingkat Risiko Postur Kerja Dan Faktor Individu Dengan Keluhan Musculoskeletal Disorders Pekerja Mebel Tunjungsekar, Aquila Ghafril Azizah, Mochamad Yusuf, Anita Sulistyorini, Agung Kurniawan

National Journal of Occupational Health and Safety

The high poverty rate in Indonesia can be addressed through the contribution of Micro, Small, and Medium Enterprises (MSMEs), which absorb approximately 57.78% of the workforce in the informal sector. However, this sector faces risks of workplace accidents and occupational diseases that can impact workers' productivity and well-being. Musculoskeletal Disorders (MSDs) account for 42% to 58% of all recorded occupational diseases globally. Preliminary observations identified symptoms of MSDs, such as neck stiffness and back pain, among furniture workers in the informal sector of Tunjungsekar. This study aims to determine the relationship between the risk levels of work posture and individual …

Manajemen Rumah Sakit Dalam Kesiapsiagaan Menghadapi Bencana Di Rsud Balaraja: Metode Hospital Safety Index, Puspita Gaharu Nisaa, Robiana Modjo

National Journal of Occupational Health and Safety

Hospitals are required to provide health services under disaster conditions, serving as the front line to help survivors and patients. RSUD Balaraja of Tangerang Regency, the only Type B hospital owned by the Regency Government, is exposed to high potential disaster hazards, including floods, extreme waves, abrasions and tsunamis, as well as moderate risk of earthquakes. This study aims to analyse hospital management in disaster preparedness using a cross-sectional design with quantitative and qualitative approaches through Module 4 of the Hospital Safety Index and a phenomenological approach. The results showed that hospital management was rated as moderately safe in disaster …

Gambaran Persepsi Pengawas Terhadap Efektivitas Geotab Dalam Mengendalikan Risiko Kecelakaan Kendaraan Ringan Di Divisi X, Aisyah Yasmin Zafirah, Chandra Satrya

National Journal of Occupational Health and Safety

This study aims to understand supervisors' perceptions of the effectiveness of Geotab as a control measure for mitigating the risk of collisions involving light vehicles. Conducted in Division X of PT. X, a mining industry, from February to June 2023, this descriptive, semi-qualitative study collected data through control effectiveness questionnaires, interviews, and document review. The variables studied include the relevance, coverage, reliability, reactivity, resource competence, and supervision system of Geotab. Questionnaire results showed supervisor perception scores of 3.09 for relevance (appropriate), 3.10 for coverage (appropriate), 3.06 for reliability (appropriate), 2.99 for reactivity (appropriate), 2.93 for resource competence, and 2.95 for …

Takotsubo Syndrome: An International Expert Consensus Report On Practical Challenges And Specific Conditions (Part-2: Specific Entities, Risk Stratification And Challenges After Recovery), Kenan Yalta, John E Madias, Nicholas G Kounis, Shams Y-Hassan, Marija Polovina, Servet Altay, Alexandre Mebazaa, Mehmet Birhan Yilmaz, Yuri Lopatin, Mamas A Mamas, Robert J Gil, Ritu Thamman, Abdallah Almaghraby, Biykem Bozkurt, Gani Bajraktari, Thomas Fink, Vassil Traykov, Stephane Manzo-Silberman, Ulvi Mirzoyev, Sekib Sokolovic, Zviad V Kipiani, Cecilia Linde, Petar M Seferovic

Faculty, Staff and Students Publications

Takotsubo syndrome (TTS) still remains as an enigmatic phenomenon. In particular, long-term challenges (including clinical recurrence and persistent symptoms) and specific entities in the setting of TTS have been the evolving areas of interest. On the other hand, a significant gap still exists regarding the proper risk-stratification of this phenomenon in the short and long terms. The present paper, the second part (part-2) of the consensus report, aims to discuss less well-known aspects of TTS including specific entities, challenges after recovery and risk-stratification.

Ten-Year Outcomes After Bariatric Surgery In Adolescents, Justin R Ryder, Todd M Jenkins, Changchun Xie, Anita P Courcoulas, Carroll M Harmon, Michael A Helmrath, Stephanie Sisley, Marc P Michalsky, Mary Brandt, Thomas H Inge

Faculty, Staff and Students Publications

No abstract provided.

Opioid Use In Thoracic Surgery: A Retrospective Study On Postoperative Complications, Jerry Xiao, Duc T Nguyen, Zoe K Lichtenberg, Elsie Rizk, Leonora M Meisenbach, Ray Chihara, Edward A Graviss, Min P Kim

Faculty, Staff and Students Publications

Background: Opioids are important medications that are used to control postoperative pain. The enhanced recovery after surgery (ERAS) program has reduced opioid use after surgery. In a surgical practice with a robust ERAS program, we wanted to determine if there was a relationship between in-hospital opioid use and postoperative complications.

Methods: We performed a retrospective nested case-control study of patients who underwent thoracic surgical intervention at the Houston Methodist Hospital (HMH) between 11/2020 and 11/2021 from the thoracic surgery database with hospital morphine milligram equivalent (MME) information, comparing patients who did and did not experience postoperative complications. We determined the …

Takotsubo Syndrome: An International Expert Consensus Report On Practical Challenges And Specific Conditions (Part-1: Diagnostic And Therapeutic Challenges), Kenan Yalta, John E Madias, Nicholas G Kounis, Shams Y-Hassan, Marija Polovina, Servet Altay, Alexandre Mebazaa, Mehmet Birhan Yilmaz, Yuri Lopatin, Mamas A Mamas, Robert J Gil, Ritu Thamman, Abdallah Almaghraby, Biykem Bozkurt, Gani Bajraktari, Thomas Fink, Vassil Traykov, Stephane Manzo-Silberman, Ulvi Mirzoyev, Sekib Sokolovic, Zviad V Kipiani, Cecilia Linde, Petar M Seferovic

Faculty, Staff and Students Publications

In the recent years, there has been a burgeoning interest in Takotsubo syndrome (TTS), which is renowned as a specific form of reversible myocardial dysfunction. Despite the extensive literature available on TTS, clinicians still face several practical challenges associated with the diagnosis and management of this phenomenon. This potentially results in the underdiagnosis and improper management of TTS in clinical practice. The present paper, the first part (part-1) of the consensus report, aims to cover diagnostic and therapeutic challenges associated with TTS along with certain recommendations to combat these challenges.

Documenting Adaptations To An Evidence-Based Intervention In 58 Resource-Variable Pediatric Oncology Hospitals Across Implementation Phases, Alejandra Catalina Quesada-Stoner, Sayeda Islam, Sara Malone, Kim Prewitt, Bobbi J Carothers, Douglas A Luke, Virginia R R Mckay, Et Al.

2020-Current year OA Pubs

BACKGROUND: Adaptation of evidence-based interventions (EBIs) often occurs when implemented in new local contexts and settings. It is unclear, however, during which phase of implementation adaptations are most frequently made and how these changes may impact the fidelity, effectiveness, and sustainability of the EBI. Pediatric Early Warning Systems (PEWS) are EBIs for early identification of deterioration in hospitalized children with cancer. This study evaluates adaptations of PEWS made among resource-variable pediatric oncology hospitals in Latin America implementing and sustaining PEWS.

METHODS: We conducted a cross-sectional survey among pediatric oncology centers participating in Proyecto Escala de Valoración de Alerta Temprana (EVAT), …

Csf Proteomics Identifies Early Changes In Autosomal Dominant Alzheimer's Disease, Yuanyuan Shen, Jigyasha Timsina, Gyujin Heo, Aleksandra Beric, Muhammad Ali, Ciyang Wang, Chengran Yang, Yueyao Wang, Daniel Western, Menghan Liu, Priyanka Gorijala, John Budde, Anh Do, Haiyan Liu, Brian Gordon, Jorge J Llibre-Guerra, Nelly Joseph-Mathurin, Richard J Perrin, Dario Maschi, Eric Mcdade, John C Morris, Randall J Bateman, Laura Ibanez, Yun Ju Sung, Carlos Cruchaga, Et Al.

2020-Current year OA Pubs

In this high-throughput proteomic study of autosomal dominant Alzheimer's disease (ADAD), we sought to identify early biomarkers in cerebrospinal fluid (CSF) for disease monitoring and treatment strategies. We examined CSF proteins in 286 mutation carriers (MCs) and 177 non-carriers (NCs). The developed multi-layer regression model distinguished proteins with different pseudo-trajectories between these groups. We validated our findings with independent ADAD as well as sporadic AD datasets and employed machine learning to develop and validate predictive models. Our study identified 137 proteins with distinct trajectories between MCs and NCs, including eight that changed before traditional AD biomarkers. These proteins are grouped …

A Large Scale Multi Institutional Study For Radiomics Driven Machine Learning For Meningioma Grading, Mert Karabacak, Shiv Patil, Rui Feng, Raj K. Shrivastava, Konstantinos Margetis

Department of Medicine Faculty Papers

This study aims to develop and evaluate radiomics-based machine learning (ML) models for predicting meningioma grades using multiparametric magnetic resonance imaging (MRI). The study utilized the BraTS-MEN dataset's training split, including 698 patients (524 with grade 1 and 174 with grade 2-3 meningiomas). We extracted 4872 radiomic features from T1, T1 with contrast, T2, and FLAIR MRI sequences using PyRadiomics. LASSO regression reduced features to 176. The data was split into training (60%), validation (20%), and test (20%) sets. Five ML algorithms (TabPFN, XGBoost, LightGBM, CatBoost, and Random Forest) were employed to build models differentiating low-grade (grade 1) from high-grade …

Comparing Student And Np Faculty Simulation Satisfaction And Confidence Following Debriefing, Rhonda D'Agostino

Doctor of Nursing Practice Scholarly Project

The utilization of simulation technology can increase critical thinking, as well as advance practice skills, satisfaction and confidence in learning. The purpose of this research was to evaluate the impact of in-person student debriefing on students and NP faculty confidence and satisfaction in student learning utilizing standardized patient simulation. The study was open to the 50 enrolled students and 10 faculty participating in the summative SP simulation for advanced health assessment at Pace University’s Pleasantville campus. Students were randomly selected to undergo in-person debriefing by faculty. After simulation, students and faculty participated in a survey. Of the 33 students, 15 …

Staff Education To Nurses Of Five Departments Performing Point-Of-Use Treatment, Natalia G. Nunez

Walden Dissertations and Doctoral Studies

Staff Education to Nurses of Five Departments Performing Point-of-Use Treatment by Natalia G. Nunez MPH, Walden University, 2019 BS, Florida International University, 2011 Project Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Nursing Practice Walden University November 2024 Point-of-use treatment (POU) treatment is the first step of sterilization, and it is critical for staff performing this process to undergo proper education and training as noted by the Centers for Disease Control and Prevention (CDC). Performing proper POU treatment reduces the risk of infections in patients and extends the life of the instruments and devices. A …

Moving Teamwork Into Teaming: Evaluating A Team-Based Model Of Nursing Care, Katie Lynn Maloney

Walden Dissertations and Doctoral Studies

Nursing practice faces staffing shortages, complex patient care, and a need to develop creative ways to fill staffing holes within the acute care clinical setting (Beckett et al., 2021). A hospital in New Hampshire, United States implemented a team-based nursing care model on a geriatric psychiatric unit in January 2023. The model has been in place for 18 months. The focus of this Doctor of Nursing Practice (DNP) quality improvement (QI) evaluation project was to determine if implementing the team-based nursing model of care improved patient outcomes such as falls, restraint use, and hospital-acquired pressure injuries and reduced the number …

A Validated Method For Non-Invasive Urine Collection In Sodium Polyacrylate-Based Diapers For Pcr Detection Of Uropathogens, Tyler Vine, Rob E. Carpenter, Debbie Bridges

Human Resource Development Faculty Publications and Presentations

This dataset provides information from a study that validates a method for non-invasive urine collection utilizing sodium polyacrylate-based diapers, designed for polymerase chain reaction (PCR) detection of uropathogens. The dataset includes samples from 17 participants, comprising seven clinically contrived samples inoculated with known uropathogens and ten samples collected from volunteers wearing sodium polyacrylate-based diapers. The study involved optimizing urine extraction from the diaper matrices, ensuring minimal loss of diagnostic sensitivity for downstream quantitative PCR (qPCR) analysis. The qPCR targeted 22 uropathogens, six fungal species, and 18 antimicrobial resistance (AMR) genes, providing comprehensive molecular characterization of urinary pathogens. Comparative analyses were …

12-05-24 Hsc Committee Meeting Notice, Patricia Serna

HSC Committee (A subcommittee of the UNM Board of Regents)

12-05-24 HSC Committee Meeting Notice

Preventing Delays In Initiation Of Radiation Therapy Following Breast Conserving Surgery – A Process Improvement, Catherine Oplinger, Msn, Rn, Ocn, Amb-B, Margaret Wight, Ba, Ods-C

Kimmel Cancer Center Papers, Presentations, and Grand Rounds

Background

• In July of 2023 new guidelines were released by Commission on Cancer (COC) related to start of radiation treatment following definitive breast conserving surgery for patients who were not previously treated. (1)
• Previous tracking at our institution was reflective which did not allow for prevention of start of radiation falling outside of the sixty-day window recommended in the new guidelines.
• Discussion at a weekly tumor board indicated that a process improvement could benefit our patient outcomes by assuring start of radiation within the recommended guidelines.
• Clinical reasons such as chemotherapy following surgery, seroma, healing issues, or infection are acceptable …

Strategies To Reduce Meditation Errors Hospitals, Elizabeth Davies

Walden Dissertations and Doctoral Studies

Each year, nearly 100,000 patients in the United States die as a result of medication errors. Medication errors are a concern to hospital leaders, resulting in increased expenses, extended hospital stays, and patient harm. Grounded in the Lean Six Sigma quality model, the purpose of this qualitative single case study was to explore the strategies three hospital managers in one hospital system in the eastern United States used to reduce medication errors. Data were collected through semistructered interviews, archival hospital documents, and analyzed using Yin's 5-step approach. The findings revealed key themes, including prioritizing staff training, building a safety culture, …

Question Answering For Electronic Health Records: Scoping Review Of Datasets And Models, Jayetri Bardhan, Kirk Roberts, Daisy Zhe Wang

Faculty, Staff and Student Publications

Background: Question answering (QA) systems for patient-related data can assist both clinicians and patients. They can, for example, assist clinicians in decision-making and enable patients to have a better understanding of their medical history. Substantial amounts of patient data are stored in electronic health records (EHRs), making EHR QA an important research area. Because of the differences in data format and modality, this differs greatly from other medical QA tasks that use medical websites or scientific papers to retrieve answers, making it critical to research EHR QA.

Objective: This study aims to provide a methodological review of existing works on …

Risk-Stratified Treatment For Drug-Susceptible Pulmonary Tuberculosis, Vincent K Chang, Marjorie Z Imperial, Patrick P J Phillips, Gustavo E Velásquez, Payam Nahid, Andrew Vernon, Ekaterina V Kurbatova, Susan Swindells, Richard E Chaisson, Susan E Dorman, John L Johnson, Marc Weiner, Amina Jindani, Thomas Harrison, Erin E Sizemore, William Whitworth, Wendy Carr, Kia E Bryant, Deron Burton, Kelly E Dooley, Melissa Engle, Pheona Nsubuga, Andreas H Diacon, Nguyen Viet Nhung, Rodney Dawson, Radojka M Savic, Aids Clinical Trial Group, Tuberculosis Trials Consortium

Faculty, Staff and Student Publications

The Phase 3 randomized controlled trial, TBTC Study 31/ACTG A5349 (NCT02410772) demonstrated that a 4-month rifapentine-moxifloxacin regimen for drug-susceptible pulmonary tuberculosis was safe and effective. The primary efficacy outcome was 12-month tuberculosis disease free survival, while the primary safety outcome was the proportion of grade 3 or higher adverse events during the treatment period. We conducted an analysis of demographic, clinical, microbiologic, radiographic, and pharmacokinetic data and identified risk factors for unfavorable outcomes and adverse events. Among participants receiving the rifapentine-moxifloxacin regimen, low rifapentine exposure is the strongest driver of tuberculosis-related unfavorable outcomes (HR 0.65 for every 100 µg∙h/mL increase, …

Executive Summary: Clinical Practice Guideline Obstetrics Diabetes Management, Carole N. Louis

Walden Dissertations and Doctoral Studies

Summary A clinical practice guideline (CPG) was developed because the perinatal department lacked standardized management of pregestational and gestational diabetes. The practice issue is relevant since managing maternal glucose ranges during pregnancy mitigates adverse maternal and neonatal outcomes. The practice-focused question asks, “What are the best practices to manage diabetes in the intrapartum and postpartum settings?” The project was designed to develop an evidence-based protocol to provide standardized management for nurses and providers. Most studies in the literature search were quantitative sources with either A or B overall quality ratings. Based on the evidence, the intrapartum target maternal glucose range …

Home And Community-Based Case Manager Job Satisfaction During The Covid-19 Public Health Emergency, Timothy Frederick Conroy

Walden Dissertations and Doctoral Studies

There is limited information on the impact on Home and Community-Based Services (HCBS) case managers’ job satisfaction as COVID-19 policies altered the way their jobs were performed. Many HCBS case managers in the United States experience high levels of turnover and burnout, resulting in difficulty maintaining appropriate service levels. Public health emergency (PHE) policies used to limit exposure of high-risk community-based individuals to COVID-19 resulted in various adjustments to traditional job responsibilities. The purpose of this research was to qualitatively study the impact of HCBS policy changes on the job satisfaction of HCBS case managers prior to and throughout the …

The Relationship Of Dietary Pattern And Physical Activity On Cholesterol Level In Young Adults, Wahyuni Sammeng

Indonesian Journal of Public Health Nutrition (IJPHN)

High blood cholesterol levels are a serious problem because they are one of the risk factors for degenerative diseases such as cardiovascular. Research data shows that in Ambon City, 32.49% of the population has the habit of consuming fatty/cholesterol/fried foods ≥1 time per day. The purpose of this study was to determine the relationship between dietary habit and physical activity with blood cholesterol levels. The type of research used was quantitative, sampling technique used was convenience sampling for 30 people. The independent variables in this study were dietary intake (amount, frequency, and type) measured using a semi-quantitative FFQ and physical …

Different Food Coping Strategies In Urban And Semi-Urban Areas During Coronavirus Disease 2019 (Covid-19) Pandemic, Sandra Fikawati, Ahmad Syafiq, Rizna Notarianti, Syilga Cahya Gemily

Indonesian Journal of Public Health Nutrition (IJPHN)

Consumption-related behavior implemented as an effort to maintain household food security is referred to as a food coping strategy (FCS). This study aims to describe the selection of FCS by families in urban and semi-urban areas in Indonesia during the COVID-19 pandemic. This research is a cross-sectional study with a total sample of 517 people who live in urban (Jakarta) and semi-urban (Depok) areas. The research data was taken from primary research data that had been collected online and purposively through Posyandu cadres who had access to family/community in October-December 2020. Data analysis used the chi-square test and multiple logistic …

The Effect Of Giving Calliandra Honey Water On Increasing Vo2max In Soccer Athletes, Masako Christina, Diah Mulyawati Utari

Indonesian Journal of Public Health Nutrition (IJPHN)

Soccer athletes need to have good cardiorespiratory endurance because they are required to move from one place to another in order to keep up with opponents who move with or without the ball. However, in 2020, the majority (47%) of teenage athletes in game sports had VO2max score in the lower category. VO2max is used as the gold standard in determining a person's cardiorespiratory endurance. The higher the VO2max value, the better a person's cardiorespiratory endurance. This study aims to determine the relationship of consumption of calliandra honey water and VO2max value in soccer athletes in PPOP DKI Jakarta Province …

Experimental And Modeling Approaches To Determine Drug Diffusion Coefficients In Artificial Mucus, Ashley C. Wynne, Brandon S. Abbott, Reza Niazi, Kayla Ann Foley, Keisha Walters

Chemical Engineering Faculty Publications and Presentations

Asthma, usually characterized by inflammation and mucus accumulation, causes restricted airflow and impaired lung function. The physiological and biochemical characteristics of mucus pose a strong barrier for drugs administered orally or via the pulmonary route for asthma treatment. In this study, two drugs commonly employed in the treatment of asthma, theophylline and albuterol, were placed in contact with an artificial mucus layer, measuring their interface concentrations, and modeling the concentration profiles to determine their diffusion coefficients. To monitor the diffusion process, the upper surface of a mucus layer was placed in contact with the drug solutions and the lower …

Tumor-Associated Tractography Derived From High-Angular-Resolution Q-Space Mri May Predict Patterns Of Cellular Invasion In Glioblastoma, Owen P Leary, John P Zepecki, Mattia Pizzagalli, Steven A Toms, David D Liu, Yusuke Suita, Yao Ding, Jihong Wang, Renjie He, Caroline Chung, Clifton D Fuller, Jerrold L Boxerman, Nikos Tapinos, Richard J Gilbert

Faculty, Staff and Student Publications

BACKGROUND: The invasion of glioblastoma cells beyond the visible tumor margin depicted by conventional neuroimaging is believed to mediate recurrence and predict poor survival. Radiomic biomarkers that are associated with the direction and extent of tumor infiltration are, however, non-existent.

METHODS: Patients from a single center with newly diagnosed glioblastoma (

RESULTS: In the principal enrollment cohort of patients with glioblastoma, all cases displayed tractography patterns with tumor-intersecting tract bundles extending into brain parenchyma, a phenotype which was reproduced in PDX mice as well as in a larger comparison cohort of glioblastoma patients (

CONCLUSIONS: QSI discriminates tumor-specific patterns of …

Volumetric Ct Assessment Of In Situ Induced Hepatic Lesions In A Transgenic Swine Model, Derek Smetanick, Danielle Stolley, David Fuentes, Natalie W Fowlkes, Faith Shakoor, Maria Sophia Stenkamp, Samantha Hicks, Steve Parrish, Erik Cressman

Faculty, Staff and Student Publications

The growth rate of in situ-induced hepatic lesions in an Oncopig large animal model is quantitatively assessed. Oncopigs (n = 9) received baseline triple-phase CT scans prior to lesion induction. Lesions were subsequently induced by delivering the Ad-Cre vector to four locations in the liver. Triple-phase CT scans were obtained weekly to track the growth of the lesions. Animals were sacrificed at 14, 21, or 28 days (n = 3 in each group). The overall success rate of lesion generation was ~78%. Histopathology sections consistently revealed lesions that were highly inflammatory and consisted of a large leukocyte population without clear …

Type I Met Inhibitors Cooperate With Pd-1 Blockade To Promote Rejection Of Hepatocellular Carcinoma, Ricardo Deazevedo, Madeline Steiner, Broderick X Turner, Arthur Liu, Sherwin Newton, Joanna Schmidt, Rachel Fleming, Angelica Tolentino, Ahmed O Kaseb, Michael A Curran

Faculty, Staff and Student Publications

Blockade of the immune checkpoints programmed death-1 (PD-1) and cytotoxic lymphocyte antigen 4 has improved outcomes for patients with hepatocellular carcinoma (HCC), yet most still fail to achieve objective clinical benefit. MET plays key roles in both HCC tumorigenesis and immunosuppressive conditioning; however, inhibition of MET causes upregulation of PD-ligand 1 (PD-L1) suggesting the use of these inhibitors in the context of PD-1 blockade. We sought to investigate across the Hepa1-6, HCA-1 and diethylnitrosamine (DEN) models of HCC whether the combination of more specific type I versus more pleiotropic type II MET inhibitors would confer superior outcomes in combination with …