Medicine and Health Sciences Commons^™

Determining The N-Glycan And Collagen/Extracellular Matrix Protein Compositions In A Novel Outcome Cohort Of Prostate Cancer Tissue Microarrays Using Maldi-Msi, Jordan P Hartig, Joseph E Ippolito, Et Al.

2020-Current year OA Pubs

Using matrix-assisted laser desorption/ionization mass spectrometry imaging techniques on a unique cohort of prostate cancer tissues, we highlighted several molecular characteristics of matrix that have potential to act as early predictors of prostate cancer metastasis.

Essentials Of Genomics In Nursing Undergraduate Education: A Discussion Paper, Sarah L. Dewell, Kathleen A. Muglia, Letitia Y. Graves, Rachel Joseph, Kara L. Mangold, Laura Grayson Roselli, Anne L. Ersig, Trina K. Walker

College of Nursing Faculty Research and Publications

Aim

To map the 2021 American Association of Colleges of Nursing Essentials to the American Nurses Association Essentials of Genomic Nursing for all nurses and provide resources for nursing faculty to support the seamless integration of genomics into existing undergraduate curricula.

Background

Since the completion of the Human Genome Project in 2003, rapid advancements in genomic science leading to practical applications of genomics have revolutionized all areas of healthcare. Nursing is built on foundational life sciences, including genomics. As the largest segment of the healthcare workforce, who spend the most time with patients and families, nurses play a critical role …

Anti-Egfr Aptamer Exhibits Direct Anti-Cancer Effects In Nsclc Cells Harboring Egfr L858r Mutations, Brian J. Thomas, Sania Z. Awan, Trupti Joshi, Mark A. Daniels, David Porciani, Donald H. Burke

Biomedical Sciences

Non-small cell lung cancer (NSCLC) adenocarcinoma (LUAD) is a leading cause of death worldwide. Activating mutations in the tyrosine kinase domain of the oncogene epidermal growth factor receptor (EGFR) are responsible for ~10–50% of all LUAD cases. Although tyrosine kinase inhibitors (TKIs) have been effective in prolonging patient survival and quality of life, acquired resistance and disease progression are inevitable, presenting a clear unmet need for alternative or adjuvant therapeutics. Here we show that an anti-EGFR aptamer (EGFRapt) decreases viability and tumor growth of LUAD cell lines harboring the L858R ± T790M mutation in EGFR. Additionally, we elucidate …

Small And Long Non-Coding Rna Analysis For Humantrophoblast-Derived Extracellular Vesicles And Their Effect On The Transcriptome Profile Of Human Neural Progenitor Cells, Jessica A. Kinkade, Pallav Singh, Mohit Verma, Teka Khan, Toshihoko Ezashi, Nathan J. Bivens, R. Michael Roberts, Trupti Joshi, Cheryl S. Rosenfeld

Biomedical Sciences

In mice, the fetal brain is dependent upon the placenta for factors that guide its early development. This linkage between the two organs has given rise to the term, the placenta–brain axis. A similar interrelationship between the two organs may exist in humans. We hypothesize that extracellular vesicles (EVs) released from placental trophoblast (TB) cells transport small RNA and other informational biomolecules from the placenta to the brain where their contents have pleiotropic effects. Here, EVs were isolated from the medium in which human trophoblasts (TBs) had been differentiated in vitro from induced pluripotent stem cells (iPSC) and from cultured …

Comprehensive Clinical Implementation, Workflow, And Fmea Of Bespoke Silicone Bolus Cast From 3d Printed Molds Using Open-Source Resources, Dean Hobbis, Michael D Armstrong, Samir H Patel, Riley C Tegtmeier, Brady S Laughlin, Shadi Chitsazzadeh, Edward L Clouser, Jennifer L Smetanick, Justin Pettit, Justin D Gagneur, Joshua B Stoker, Yi Rong, Courtney R Buckey

2020-Current year OA Pubs

BACKGROUND: Bolus materials have been used for decades in radiotherapy. Most frequently, these materials are utilized to bring dose closer to the skin surface to cover superficial targets optimally. While cavity filling, such as nasal cavities, is desirable, traditional commercial bolus is lacking, requiring other solutions. Recently, investigators have worked on utilizing 3D printing technology, including commercially available solutions, which can overcome some challenges with traditional bolus.

PURPOSE: To utilize failure modes and effects analysis (FMEA) to successfully implement a comprehensive 3D printed bolus solution to replace commercial bolus in our clinic using a series of open-source (or free) software …

Precision Functional Mapping To Advance Developmental Psychiatry Research, Alyssa K Labonte, M Catalina Camacho, Julia Moser, Sanju Koirala, Timothy O Laumann, Scott Marek, Damien Fair, Chad M Sylvester

2020-Current year OA Pubs

Many psychiatric conditions have their roots in early development. Individual differences in prenatal brain function (which is influenced by a combination of genetic risk and the prenatal environment) likely interact with individual differences in postnatal experience, resulting in substantial variation in brain functional organization and development in infancy. Neuroimaging has been a powerful tool for understanding typical and atypical brain function and holds promise for uncovering the neurodevelopmental basis of psychiatric illness; however, its clinical utility has been relatively limited thus far. A substantial challenge in this endeavor is the traditional approach of averaging brain data across groups despite individuals …

Limitations And Potential Of Κor Biased Agonists For Pain And Itch Management, Amal El Daibani, Manish K Madasu, Ream Al-Hasani, Tao Che

2020-Current year OA Pubs

The concept of ligand bias is based on the premise that different agonists can elicit distinct responses by selectively activating the same receptor. These responses often determine whether an agonist has therapeutic or undesirable effects. Therefore, it would be highly advantageous to have agonists that specifically trigger the therapeutic response. The last two decades have seen a growing trend towards the consideration of ligand bias in the development of ligands to target the κ-opioid receptor (κOR). Most of these ligands selectively favor G-protein signaling over β-arrestin signaling to potentially provide effective pain and itch relief without adverse side effects associated …

Transmembrane Protein 53 Craniotubular Dysplasia (Omim # 619727): The Skeletal Disease And Consequent Blindness Of This New Disorder, Michael P Whyte, Robert S Weinstein, Paul H Phillips, William H Mcalister, Raghuhr H Ramakrishnaiah, G Bradley Schaefer, Rongsheng Cai, Michele R Hutchison, Shenghui Duan, Gary S Gottesman, Steven Mumm

2020-Current year OA Pubs

Craniotubular dysplasia, Ikegawa type (OMIM #619727) denotes the autosomal recessive skeletal disease identified in 2021 featuring blindness acquired in childhood. Five young members of four Indian families harbored a homozygous indel within TMEM53 (OMIM *619722), the gene that encodes transmembrane protein 53 (TMEM53). When intact, TMEM53 spans the nuclear envelope of osteoprogenitor cells, dampens BMP-SMAD signaling, and thereby slows bone formation. Consequently, defective TMEM53 accelerates osteogenesis. Herein, an American boy is compound heterozygous for a novel deletion and a novel missense mutation within TMEM53. His vision and sensorineural hearing became impaired. Radiographic survey revealed diploic thickening of his skull, broad …

Cohort Expansion And Genotype-Phenotype Analysis Of Rab11a-Associated Neurodevelopmental Disorder, Maria Carla Borroto, Jorge L Granadillo, Et Al.

2020-Current year OA Pubs

BACKGROUND: GTPases of the Rab family are important orchestrators of membrane trafficking, and their dysregulation has been linked to a variety of neuropathologies. In 2017, we established a causal link between RAB11A variants and developmental and epileptic encephalopathy. In this study, we expand the phenotype of RAB11A-associated neurodevelopmental disorder and explore genotype-phenotype correlations.

METHODS: We assessed 16 patients with pathogenic or likely pathogenic RAB11A variants, generally de novo, heterozygous missense variants. One individual had a homozygous nonsense variant, although concomitant with a pathogenic LAMA2 variant, which made their respective contributions to the phenotype difficult to discriminate.

RESULTS: We reinforce the …

The Intersection Of Substance Use Stigma And Anti-Black Racial Stigma: A Scoping Review, Rashmi Ghonasgi, Maria E Paschke, Rachel P Winograd, Catherine Wright, Eva Selph, Devin E Banks

2020-Current year OA Pubs

BACKGROUND: Substance use stigma poses a barrier to treatment and recovery from substance use disorder. Stigma is amplified when intersecting with other stigmatized identities, particularly Black racial identity. Despite increasing attention to the intersecting roles of racial and substance use stigma, it is unknown how these stigmas interact to impact treatment and health outcomes among Black people who use drugs. This scoping review examines empirical research documenting differential impacts of race and racism on substance use stigma.

METHODS: We systematically searched PsychInfo and PubMed databases. Eligible studies were conducted in the U.S.; examined a Black sample, subsample, or experimental condition/variable …

Diclofenac Sensitizes Multi-Drug Resistant Acinetobacter Baumannii To Colistin, Fabiana Bisaro, Clay D. Jackson-Litteken, Jenna C. Mcguffey, Anna J. Hooppaw, Sophie Bodrog, Leila Jebeli, Manon Janet-Maitre, Juan C. Ortiz-Marquez, Tim Van Opijnen, Nichollas E. Scott, Gisela Di Venanzio, Mario F. Feldman

2020-Current year OA Pubs

Acinetobacter baumannii causes life-threatening infections that are becoming difficult to treat due to increasing rates of multi-drug resistance (MDR) among clinical isolates. This has led the World Health Organization and the CDC to categorize MDR A. baumannii as a top priority for the research and development of new antibiotics. Colistin is the last-resort antibiotic to treat carbapenem-resistant A. baumannii. Not surprisingly, reintroduction of colistin has resulted in the emergence of colistin-resistant strains. Diclofenac is a non-steroidal anti-inflammatory drug used to treat pain and inflammation associated with arthritis. In this work, we show that diclofenac sensitizes colistin-resistant A. baumannii clinical strains …

A Case Report Of An Unprovoked Neonatal Pulmonary Embolism: Management Strategies And Cardiopulmonary Complications, Aashana Dhruva Cowan, Ezinwanne Rosemary Emelue, George Spyropoulos, Mehul Thakkar, Jorge Di Paola, Andrew Glatz, Edon J Rabinowitz

2020-Current year OA Pubs

BACKGROUND: Neonatal pulmonary embolism is a rare occurrence, especially when idiopathic, instead occurring in patients with identifiable risk factors including severe dehydration, presence or history of a central venous line, or identifiable genetic causes. Given the rarity of paediatric and neonatal pulmonary emboli, few guidelines exist to support the clinician in both the initial resuscitation and ongoing management of the critically ill patient with pulmonary emboli.

CASE SUMMARY: We present a 5-day-old female with unprovoked massive pulmonary embolism and associated haemodynamic compromise. She presented with central cyanosis and weak respiratory effort with hypoxaemia, persistent tachycardia, and hypotension despite initial fluid …

The Known And Unknown Reality Of Knee Dislocations: A Systematic Review, Zachary D Randall, Matthew J Strok, Jacob W Mazzola, Ravi Agrawal, Lauren H Yaeger, Marschall B Berkes

2020-Current year OA Pubs

BACKGROUND: Knee dislocations (KD) are limb threatening injuries known to cause significant dysfunction and disability. This review aims to summarize KD knowledge and uncover areas where more research is needed.

METHODS: The published literature was queried according to PRISMA guidelines. Studies eligible for inclusion were clinical studies of knee dislocations. Studies published before 1990, or that focused on patellofemoral dislocation were excluded.

RESULTS: A total of 132 studies involving 43,869 knee dislocations were analyzed. The majority of patients were young adult males, with high-velocity trauma, particularly motor vehicle accidents, being the most common cause. Substance use and alcohol involvement were …

Hook Of Hamate Regrowth After Surgical Excision: A Report Of Two Cases, Michele Christy, Charles A Goldfarb, Douglas Carlan

2020-Current year OA Pubs

Two high-level baseball players sustained a hook of hamate fracture while batting and were treated with excision of the fragment. Both players returned to play, and both had repeat fractures through a regenerated hook. This phenomenon of hook of hamate regeneration has not been well described in the literature. In conclusion, hook of hamate regeneration can occur after fracture fragment excision. The incidence and risk of this sequela as well as its association with surgical technique is uncertain.

Influence Of Physical Activity Measurement On The Association Between Life's Essential 8 And Incident Cardiovascular Disease In Older Women, Eric T Hyde, Steve Nguyen, Michael J Lamonte, Chongzhi Di, John Bellettiere, Lesley F Tinker, Randi E Foraker, Hilary A Tindle, Marcia L Stefanick, Andrea Z Lacroix

2020-Current year OA Pubs

OBJECTIVE: The American Heart Association's Life's Essential 8 (LE8) metric includes self-reported physical activity as one of the metrics for assessing cardiovascular health. Self-reported physical activity is prone to misclassification, whereas accelerometer measures are less biased. We examined associations of LE8 and incident cardiovascular disease (CVD) using self-reported and accelerometer-measured physical activity.

METHODS: Participants in the Women's Health Initiative (WHI) Objective Physical Activity and Cardiovascular Health Study (n = 4,243; mean age = 79 ± 7 years) with no CVD history completed the WHI physical activity questionnaire and the Community Healthy Activities Model Program for Seniors (CHAMPS) questionnaire prior to …

Reach Out When Help Is Needed, Michelle C. Dziurgot Dds

The Journal of the Michigan Dental Association

This editorial emphasizes the importance of recognizing signs of emotional distress, particularly in the dental field, where long work hours and patient stress can take a toll. It highlights the need for suicide prevention and awareness training, advocating for open communication and mental health support within work families.

The author shares a personal story of losing a colleague and stresses the value of the American Dental Association's Postvention Toolkit. The Michigan Dental Association’s Member Assistance Program is also recommended as a resource for mental health and emotional support.

The New Professional: Starting A Practice Vs. Buying: What’S Right For You?, Amrita Patel Dds

The Journal of the Michigan Dental Association

This month's New Professional column explores the key decision of whether to start a new dental practice or purchase an existing one. Starting a practice offers flexibility in creating a brand and using the latest technology but requires building a patient base from scratch and managing upfront costs. Purchasing an existing practice provides immediate cash flow and an established patient base but requires more upfront investment and adapting to existing systems. Dentists should consider financial readiness, long-term goals, and work-life balance when making this decision.

The Back Page: Connection And Support: It’S A Family Thing, Kristen Kemmer Dds

The Journal of the Michigan Dental Association

In March 2023, the author welcomed her second daughter while managing the challenges of being a solo dental practice owner. With a supportive team, family, and a strong network of local dental colleagues, she successfully navigated maternity leave. Her dental team handled patient care seamlessly, and she leaned on friends and fellow practitioners for advice and emergency coverage. Online support and planning helped her manage financially, while collaboration within local dental groups ensured patient needs were met. The experience reinforced the importance of connection, support, and community in balancing motherhood and practice ownership.

Mda Foundation: How Your Donations Help Support The Vina Dental Clinic -- And Other Programs, Too, Anne Berquist

The Journal of the Michigan Dental Association

In 2007, Dr. Fredric Bonine and Dr. Sam Daniels founded the VINA Community Dental Center in Brighton, Michigan, to provide affordable dental care to low-income residents. The clinic opened in 2008, charging minimal fees for cleanings and appointments. Serving 1,500 to 2,000 patients annually, the clinic relies on volunteer dentists, partnerships with educational institutions, and grants. Notably, the University of Michigan’s Victors for Veterans program offers free dental care to qualifying veterans. The MDA Foundation supports the clinic through grants, contributing to VINA’s $250,000 annual budget. Donations to the MDA Foundation fund these efforts, ensuring continued access to affordable dental …

Your Mda Team: Working For You, John Tramontana Ms, Cae

The Journal of the Michigan Dental Association

This month's cover feature introduces the Michigan Dental Association (MDA) team based in Okemos, highlighting their dedication to providing exceptional service and value to MDA members.

The team, many of whom have decades of experience, is always available to answer questions and offer support. With a focus on delivering top-notch service, the MDA staff strives to be the best dental association in the country. The article includes an overview of the team members, their roles, and a helpful "Who to Call" guide for members seeking assistance.

The executive director emphasizes the team's expertise and institutional knowledge, inviting members to reach …

J Mich Dent Assoc November 2024

The Journal of the Michigan Dental Association

Each month, The Journal of the Michigan Dental Associationprovides news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 6,200+ members. It stands as the primary publication reaching Michigan dentists. The November issue includes:

• Clinical Feature on discontinuation of lead apron use for dental radiology
• An introduction to the MDA Team and how they can be contacted to serve specific member needs
• A Back Page article on beginning practice and family
• Regular Departments: New Dentist Column, Updates on the MDA Foundation, MDA Services, Dentistry and the Law, Staff Matters

This month we welcome …

Impact Of Artificial Intelligence-Based Autosegmentation Of Organs At Risk In Low- And Middle-Income Countries, Solomon Kibudde, Awusi Kavuma, Yao Hao, Tianyu Zhao, Hiram Gay, Jacaranda Van Rheenen, Pavan Mukesh Jhaveri, Minjmaa Minjgee, Enkhsetseg Vanchinbazar, Urdenekhuu Nansalmaa, Baozhou Sun

2020-Current year OA Pubs

PURPOSE: Radiation therapy (RT) processes require significant human resources and expertise, creating a barrier to rapid RT deployment in low- and middle-income countries (LMICs). Accurate segmentation of tumor targets and organs at risk (OARs) is crucial for optimal RT. This study assessed the impact of artificial intelligence (AI)-based autosegmentation of OARs in 2 LMICs.

METHODS AND MATERIALS: Ten patients, comprising 5 head and neck (HN) cancer patients and 5 prostate cancer patients, were randomly selected. Planning computed tomography images were subjected to autosegmentation using an Food and Drug Administration-approved AI software tool and manual segmentation by experienced radiation oncologists from …

Assessing Radiology And Radiation Therapy Needs For Cancer Care In Low-And-Middle-Income Countries: Insight From A Global Survey Of Departmental And Institutional Leaders, Stephanie A Parker, Yao Hao, Et Al.

2020-Current year OA Pubs

PURPOSE: The global cancer burden and mortality rates are increasing, with significant disparities in access to care in low- and middle-income countries (LMICs). This study aimed to identify radiology and radiation therapy needs in LMICs from the perspective of departmental and institutional leaders.

METHODS AND MATERIALS: A survey was developed and conducted by the American Association of Physicists in Medicine Global Needs Assessment Committee and the American Association of Physicists in Medicine International Council. The survey, organized into 5 sections (Introduction, Infrastructure Needs, Education Needs, Research Needs, and General Information), was open to respondents from March 1, to August 16, …

Relationship Between Mri Brain-Age Heterogeneity, Cognition, Genetics And Alzheimer's Disease Neuropathology, Mathilde Antoniades, Pamela Lamontagne, Tammie Benzinger, Daniel S Marcus, John C Morris, Et Al.

2020-Current year OA Pubs

BACKGROUND: Brain ageing is highly heterogeneous, as it is driven by a variety of normal and neuropathological processes. These processes may differentially affect structural and functional brain ageing across individuals, with more pronounced ageing (older brain age) during midlife being indicative of later development of dementia. Here, we examined whether brain-ageing heterogeneity in unimpaired older adults related to neurodegeneration, different cognitive trajectories, genetic and amyloid-beta (Aβ) profiles, and to predicted progression to Alzheimer's disease (AD).

METHODS: Functional and structural brain age measures were obtained for resting-state functional MRI and structural MRI, respectively, in 3460 cognitively normal individuals across an age …

Comparison Of Accuracy Of Different Dental Age Estimation Methods In Finnish And Turkish Populations, Aysima Darici, Merih Seval Olmez, H. Cem Güngör, Paivi Rajavaara, Annina Sipola, Vuokko Anttonen, Jari Pakkila

School of Dentistry Faculty Research and Publications

Objective: The aims of this study were to assess the accuracy of Cameriere’s and Demirjian’s methods in Finnish children, and compare the findings with those of the Turkish children according to dental age.

Material and methods: Dental panoramic tomography (DPT) of children (482 Finnish, 423 Turkish) aged between 5 and 15 years were evaluated. Comparison of mean difference between estimated and chronological age was evaluated. The difference between two means was analysed using paired t-test at 95% confidence interval (CI). Pearson correlation coefficients were used to estimate the correlation between chronological and estimated ages.

Results: Demirjian’s method resulted in …

Short- And Long-Term Effects Of Conventional And Miniscrew-Assisted Rapid Palatal Expansion On Hard Tissues Using Voxel-Based Superimposition Of Serial Cone-Beam Computed Tomography Scans, Isaac R. Empson, Marinho Del Santo Jr., Chia-Ling Kuo, Manuel Lagravere Vich, Dawei Liu, Sumit Yadav, Shivam Yogesh Mehta

School of Dentistry Faculty Research and Publications

Introduction

The objective of this study was to evaluate the short-term and long-term hard-tissue changes with miniscrew-assisted rapid palatal expansion (MARPE) and rapid palatal expansion (RPE) compared with a matched control group with voxel-based superimposition using 3-dimensional cone-beam computed tomography (CBCT) scans.

Methods

A total of 180 CBCT scans were analyzed for 60 patients with a mean age of 13.9 years at 3 time points: pretreatment (T1), postexpansion (T2), and posttreatment (T3). Patients were divided into 3 groups: MARPE, RPE, and controls. Voxel-based superimposition was performed for CBCTs from T1 to T2 and T1 to T3 using the anterior cranial …

Health Outcomes In Children With Prenatal Opioid Exposure With And Without Neonatal Abstinence Syndrome In The First Seven Years Of Life: An Observational Cohort Study, Joshua Lambert, Sara Arter, Henry Ofori Duah, Teenu Xavier, Jon E. Sprague

College of Nursing Faculty Research and Publications

Introduction Prenatal opioid exposure (POE) is a major public health consequence of the opioid epidemic. Long-term health outcomes associated with POE remain unclear, especially for children with POE without a diagnosis of neonatal abstinence syndrome (NAS). Here, we aimed to describe the health outcomes of children with POE and with POE and NAS compared to unexposed children during the first 7 years of life. Design In this retrospective observational cohort study, children born between 2015 and 2022 were identified from the Maternal and Infant Data Hub (MIDH), a data repository that continuously integrates maternal, neonatal, and pediatric records from two …

Discontinuing The Use Of Lead Aprons And Thyroid Collars In Dental Imaging: Evidence-Based Guidance For Michigan Clinicians, Erika Benavides Dds, Phd, Fabiana Soki Dds, Mdsc, Phd, James R. Geist Dds, Ms, Dennis Palmieri Mph, Jd

The Journal of the Michigan Dental Association

Recent guidelines from the AAOMR and ADA recommend discontinuing the routine use of lead aprons and thyroid collars during dental imaging, citing negligible radiation exposure from modern technologies and the ineffectiveness of these shields against internal scatter radiation. Despite strong evidence, Michigan clinicians may face challenges in adopting this change due to patient concerns and outdated regulations.

This article offers practical guidance for transitioning to these updated standards, emphasizing the importance of patient communication and education while highlighting Michigan's current regulatory framework.

Malignant Transformation And Tumour Recurrence In Sacrococcygeal Teratoma: A Global, Retrospective Cohort Study., Lieke J. Van Heurn, Joep P M Derikx, Nigel Hall, Jennifer H. Aldrink, Maria M. Bailez, Lohfa B. Chirdan, Shigehisa Fumino, Afua Hesse, Tuktu Soyer, Shawn D. St Peter, Jos Twisk, Tianyou Yang, Ernst L W Van Heurn, Sct-Study Consortium

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Sacrococcygeal teratoma (SCT) is a rare congenital tumour. The risk of malignancy and recurrence are not well defined. Previous studies are small and report differing conclusions about the timing of surgery and the duration of follow-up. We studied the risk of malignant transformation and SCT recurrence after surgery to address these gaps.

METHODS: This was a global retrospective cohort study. Data of consecutive SCT patients was obtained from 145 institutes in 62 countries. Malignant transformation, defined as malignancy at initial resection, malignant recurrence or death due to malignancy, and its risk factors were analysed.

RESULTS: Of the 3612 included …

Seasons Of Kawasaki Disease During The Covid-19 Pandemic., Todd T. Nowlen, Ashraf S. Harahsheh, Geetha Raghuveer, Simon Lee, Anji T. Yetman, Nagib Dahdah, Michael A. Portman, Supriya S. Jain, Michael Khoury, Selemet Tierney, Cedric Manlhiot, Pedrom Farid, Brian W. Mccrindle

Manuscripts, Articles, Book Chapters and Other Papers

The incidence of Kawasaki Disease has a peak in the winter months with a trough in late summer/early fall. Environmental/exposure factors have been associated with a time-varying incidence. These factors were altered during the COVID-19 pandemic. The study was performed through the International Kawasaki Disease Registry. Data from patients diagnosed with acute Kawasaki Disease and Multiple Inflammatory Syndrome-Children were obtained. Guideline case definitions were used to confirm site diagnosis. Enrollment was from 1/2020 to 7/2023. The number of patients was plotted over time. The patients/month were tabulated for the anticipated peak Kawasaki Disease season (December-April) and non-peak season (May-November). Data …