Medicine and Health Sciences Commons^™

Human Immunodeficiency Virus-1 Genome From Patient With Fever, Nepal, Eans Tara Tuladhar, Bimal Sharma Chalise, Binod Khadka, Mamta Tamang, Jenish Neupane, Shankar Poudel, Lindsay Droit, Kathie A Mihindukulasuriya, Annie Elong Ngono, Yuba Nidhi Basaula, Sujan Shresta, David Wang, Krishna Das Manandhar

2020-Current year OA Pubs

A patient with fever presented to the referral infectious disease hospital in Kathmandu, Nepal. Metagenomic sequencing of the patient's serum recovered a near-complete genome of human immunodeficiency virus-1 (HIV-1), distinct from previous HIV-1 genomes from Nepal in GenBank. It shared 92.48% nucleotide identity with an HIV-1 subtype C isolate from India.

Identification And Characterization Of The Lipoprotein N-Acyltransferase In Bacteroides, Krista M Armbruster, Jiawen Jiang, Mariana G Sartorio, Nichollas E Scott, Jenna M Peterson, Jonathan Z Sexton, Mario F Feldman, Nicole M Koropatkin

2020-Current year OA Pubs

Members of the Bacteroidota compose a large portion of the human gut microbiota, contributing to overall gut health via the degradation of various polysaccharides. This process is facilitated by lipoproteins, globular proteins anchored to the cell surface by a lipidated N-terminal cysteine. Despite their importance, lipoprotein synthesis by these bacteria is understudied. In

Evaluation Of Prognostic Factors In Patients With High-Risk Classical Hodgkin Lymphoma Undergoing Autologous Transplantation, Narendranath Epperla, Amanda F Cashen, Et Al.

2020-Current year OA Pubs

There are limited data assessing the risk scores for primary treatment failure (PTF) in patients with classical Hodgkin lymphoma (cHL; PTF-cHL) undergoing autologous hematopoietic cell transplantation (auto-HCT). ECLIPSE (Evaluation of Classical Hodgkin Lymphoma patients wIth Primary treatment failure and analySis of outcomEs) is a multicenter retrospective cohort of patients with PTF-cHL (aged ≥15 years) diagnosed on or after 1 January 2005, at 15 US medical centers. PTF was defined as 1 of the following patterns of failure: (1) progressive disease by imaging during or within 6 weeks of completion of frontline chemotherapy (primary progression [PP]); (2) partial response (PR) or …

The Effect Of Nerolidol On The Renal Dysfunction Following Bilateral Ureteral Obstruction In The Rat, Harun Rashed Toumi

Thesis/ Dissertation Defenses

This thesis addressed nerolidol’s potential therapeutic and protective effects on bilateral ureteral obstruction-induced uropathy in rats. Obstructive uropathy stands as a notable contributor to acute kidney injury (AKI), accounting for 5-10% of all AKI cases worldwide, with a particularly high prevalence among the elderly, constituting 22% of AKI cases in this age group. Urinary tract obstruction, often attributed to factors such as kidney stones, urinary tract deformities and benign/malignant growths such as benign prostatic hyperplasia (BPH) in older men can lead to detrimental outcomes if left untreated, potentially progressing to kidney failure and even mortality. The severity of the kidney …

Dental Therapy In Washington State: Exploring Dental Hygienists’ Perceptions And Attitudes Towards An Emerging Workforce Model, Soy Mouy Gearheart

Dental Hygiene ETDs

Purpose: This study examines dental hygienists' perceptions of dental therapy in Washington State. Methods: A cross-sectional survey utilizing a Likert-scale questionnaire was conducted among dental hygienists recruited from Washington State Dental Jobs Facebook groups. Descriptive statistics and cross-tabulation analysis examined key variables. Results:Of the 46 participants (n=46), 72% reported that they believed dental therapy could improve access to care in underserved areas. Concerns about current educational standards for safe practice were noted. 11% expressed interest in pursuing a dental therapy degree within the next five years, motivated by interest and career opportunities. Notably, 67% of all male respondents indicated …

Educating Project Site Hospital Nurses On The Code Lavender, Jennifer Swendsen

Walden Dissertations and Doctoral Studies

With this staff education project, I aimed to educate nurses at the project site hospital about the Code Lavender program, a mental health intervention designed to address nurse burnout. Nurse burnout has risen significantly post-COVID-19 pandemic, contributing to high turnover rates and compromising patient care. Nurses are experiencing increased levels of stress, depression, and suicidal ideation, which has led to feelings of being overwhelmed, overworked, and quitting the profession, exacerbating staffing shortages and patient care hazards. The central question of this project was whether staff education on the Code Lavender program would increase nurses’ knowledge, as evidenced by improved posttest …

Intouch Week Of November 11, 2024, New York Medical College

InTouch

• More than $16,000 Raised by NYMC SOM Marathon Runners
• Department of Pediatrics Hosts Leonard Newman, M.D. ’70, Assistant Professor Research Symposium
• Jonathan Fisher, Ph.D., Presents at the Neighborhood Science Seminar Series
• NYMC Community Visits New York Historical Society Museum
• NYMC SNMA Brings Hope to Tampa Residents Impacted by Hurricanes
• NYMC Blood Drive Brings Community Together to Save Lives
• Health Literacy Club Hosts Educational Vegetable Stand
• Student Spotlight: SOM Student Takes Second Place in International Neurosurgery Innovation Competition
• Faculty Spotlight: From Pupil to Professor: Alumni Lighting the Way at NYMC

Best Practice Toolkit For Nursing Staff Caring For Ventilated Patients, Erin Belisle

Student Scholarly Projects

Practice Problem: Best practice tool kits are used to guide better outcomes for ventilated patients and staff members. Many reasons can contribute to requiring a patient to be on mechanical ventilation, but the most common reasons are a trauma event and infection.

PICOT: The PICOT question that guided this project was: In critical care staff such as nurses, respiratory therapists (RT), and critical care providers caring for mechanically ventilated patients (P), what is the effect of implementing a best practice coordination toolkit (I) compared to standard care procedures (C) on the adherence to best practices by critical care providers (O)? …

Shifting Employment And Perceptions Of Household Responsibilities During Early Stages Of The Covid-19 Pandemic In Nevada, Usa, Courtney Coughenour, Lung-Chang Chien, Brian Labus, Maxim Gakh, Pashtana Usufzy

School of Public Health Faculty Research

Background: Employment and household responsibility are critical health determinants. The COVID-19 pandemic altered the work and social landscapes in Nevada, USA through closures of workplaces and schools/childcare centers, changing patterns of employment, and household responsibilities. This study aimed to measure changes in employment status and perceived housework responsibilities among Nevada adults in December 2020, before widespread availability of COVID-19 vaccines in a pandemic-affected economy.

Methods: Using a cross-sectional telephone survey of 1,000 Nevada adults, this study compared respondent experiences and perceptions of employment and time spent on housework in December 2020 to pre-pandemic using multinominal logistic, proportional odds, and logistic …

Staff Education To Improve Medical Adherence Among African American Males With Hypertension, Veronica Ebere Ani

Walden Dissertations and Doctoral Studies

Hypertension (HTN) is the chief cause of cardiovascular disease in the United States. Due to the mortality and morbidity and the increased healthcare costs associated with HTN, nursing staff need to have knowledge to control and help patients manage the condition. HTN disproportionately affects African American men due to non-adherence to medication, lifestyle issues, and health disparities. Nurses can only support patients managing HTN if they have current evidence-based knowledge. Staff knowledge deficit was a significant issue affecting the clinic's management and control of HTN. Providers' knowledge gap was considered a leading factor in patient nonadherence to prescribed antihypertensive medications. …

Exth-52. Simultaneous Targeting Of Tumor Cells And Tumor-Associated Macrophages To Reprogram Glioblastoma By Tumor-Suppressive Microrna, Grace Nguyen, Minhye Noh, Alexandra Miller, Minxin Huang, Yulin Dai, Zhongming Zhao, Ji Young Yoo, Tae Jin Lee

Faculty, Staff and Student Publications

Glioblastoma (GBM) is the most aggressive type of primary brain tumors due in part to cell-intrinsic and cell-extrinsic mechanisms. The ability of GBM tumor to not only resist conventional therapies but also induce an immunosuppressive tumor microenvironment (TME) is thought to underlie the failure of immunotherapies. Thus, strategies to target both tumor cells and immunosuppressive immune cells, such as tumor-associated macrophages (TAMs), are of great interest. The ability of microRNA (miRNA) to target multiple genes is favorable to alter the character of the TME and cancer cells. Previously, we have shown that tumor suppressive miRNA, miR-138, can effectively regulate the …

11.11.2024 Orsp Connect, Liz Williamson

ORED Newsletter

Radiation Safety Committee Updates

Getting Started with PIVOT_RP

Small Grants Program

Predictive Association Between End-Of-Third Year Osce Scores And Achievement On Acgme Milestones During Intern Year, Katherine Berg, Jillian Zavodnick, Sally Santen, Yoon Soo Park, Anita Wilson

JeffMD Academic Affairs

Purpose

The Objective Structured Clinical Examinations (OSCEs) administered in medical school have increased in importance with the elimination of USMLE Step 2 Clinical Skills (CS)1, 2. The purpose of this study is to understand the association between student performance on an end-ofthird- year OSCE and the relevant Accreditation Council for Graduate Medical Education (ACGME) Internal Medicine (IM) Milestone 1.0 sub-competencies: Patient Care (PC1 and PC2) and Interpersonal and Communication Skills 1 (ICS1 and ICS2).

Understanding Faculty Perspectives On Health Equity Curriculum Implementation In Graduate Medical Education: A Qualitative Study, Krys Foster, Dhruvi Shah, Quinn Plunkett, Randa Sifri

Department of Family & Community Medicine Faculty Papers

BACKGROUND: Despite increased awareness of persistent healthcare disparities, integrating health equity education into medical residency curricula needs urgent expansion. The Accreditation Council for Graduate Medical Education (ACGME) mandates addressing healthcare disparities and social determinants of health, but implementation remains insufficient due to pervasive barriers.

OBJECTIVE: To explore residency faculty perspectives at one institution surrounding implementing a health equity curriculum within their programs.

METHODS: Between November 2022 and April 2023, qualitative interviews and focus groups were conducted with residency faculty participants (n = 13) from a large academic medical institution. Participants were recruited via an internal email list directory of program …

Serca Modulators Reveal Distinct Signaling And Functional Roles Of T Lymphocyte Ca2+ Stores, Md N. Uddin, David W. Thomas

Pacific Faculty Work

The allosteric SERCA (Sarcoplasmic/Endoplasmic Reticulum Ca²⁺-ATPase) activator CDN1163 has been recently added to the group of pharmacological tools for probing SERCA function. We chose to investigate the effects of the compound on T lymphocyte Ca²⁺ stores, using the well-described Jurkat T lymphocyte as a reliable cell system for Ca²⁺ signaling pathways. Our study identified the lowest concentrations of the SERCA inhibitors thapsigargin (TG) and 2,5-di-(tert butyl)-1,4-benzohydroquinone (tBHQ) capable of releasing Ca²⁺, permitting the differentiation of the TG-sensitive SERCA 2b Ca²⁺ store from the tBHQ-sensitive SERCA 3 Ca²⁺ store. We proceeded to test …

Hypothermia In Patients With Traumatic Injuries: An Integrative Review, Andrew P. Gribble, David J. Saucedo

Master's Projects

Abstract

Background: An estimated 30-50% of severely injured patients with traumatic injuries will experience hypothermia. As a result of hypothermia, several clinical manifestations such as impaired coagulation, dissociation of the oxygen curve, cardiac arrhythmias, reduced cardiac output and death. Little evidence has been published promoting specific patient re-warming protocols and the best rewarming methods, active versus passive. Few studies have focused on the pre-hospitalization treatment for hypothermia and the overall effectiveness of interventions to mitigate hypothermia to reduce morbidity and mortality. Given this knowledge, the aim of this integrative review (IR) is to research and evaluate current practices regarding hypothermia …

Genetically Determined Telomere Length In Monoclonal Gammopathy Of Undetermined Significance, Multiple Myeloma Risk And Outcome, Matteo Giaccherini, Alyssa I Clay-Gilmour, Romano Liotti, Angelica Macauda, Manuel Gentiluomo, Elizabeth E Brown, Mitchell J Machiela, Stephen J Chanock, Michelle A T Hildebrandt, Aaron D Norman, Elisabet Manasanch, S Vincent Rajkumar, Jonathan N Hofmann, Sonja I Berndt, Parveen Bhatti, Graham G Giles, Elad Ziv, Shaji K Kumar, Nicola J Camp, Wendy Cozen, Susan L Slager, Federico Canzian, Federica Gemignani, Celine M Vachon, Daniele Campa

Faculty, Staff and Student Publications

No abstract provided.

Beta-Blocker Use In Patients Undergoing Non-Cardiac Surgery: A Systematic Review And Meta-Analysis, Doménica Herrera Hernández, Bárbara Abreu, Tania S. Xiao, Andreina Rojas, Kevin López Romero, Valentina Contreras, Sol Villa Nogueyra, Zulma Sosa, Samantha M. Alvarez, Camila Sánchez Cruz, Ernesto Calderón Martinez

Department of Radiology Faculty Papers

BACKGROUND: The use of beta-blockers in the perioperative period has been widely investigated due to their potential to reduce the risk of major adverse cardiovascular and cerebrovascular events (MACCE) and mortality; yet their overall impact on various postoperative outcomes remains debated. This study constitutes a systematic review and meta-analysis of the impact of beta-blockers on mortality, MI, stroke, and other adverse effects such as hypotension and bradycardia in patients undergoing non-cardiac surgery.

METHODS: A comprehensive systematic review and meta-analysis were conducted according to PRISMA 2020 guidelines. Searches were performed across PubMed, Cochrane, Web of Science, Scopus, EMBASE, and CINAHL databases; …

Staff Education To Increase Staff Awareness On How Personal Trauma Affects Responses During Restraints, Marygoretti Kibe

Walden Dissertations and Doctoral Studies

The emotional and or physical trauma that individuals sustained while growing up may continue to adversely affect their health as adults, leading to mental health issues, depression, substance use, anxiety and secondary trauma. The prevalence of this trauma widely unacknowledged among mental healthcare staff. Trauma prevention is crucial and can be achieved through educational interventions. In clinical settings, this can prevent staff high turnover, leaving the profession, disengagement, hypervigilance, and overinvolvement. In a mental health clinical setting, this trauma can lead to overuse or misuse of restraints as the trauma staff bring to these situations drives their reactions.

Executive Summary: Staff Education Improving Cultural Competence In Mental Health Providers, Mary Osagie

Walden Dissertations and Doctoral Studies

In the current healthcare environment, providers care for an increasingly diverse patient population and are challenged with the need for cultural competency skills. Evidence indicates that there are gaps related to cultural competency among healthcare providers across all specialties and settings. This paper describes a staff education project that addressed limited cultural competence skills among nurses and staff at an ambulatory mental health clinic on the East Coast. The purpose of the project was to develop, implement, and evaluate a staff education program on cultural competency. The goal was for participants to become more culturally aware and gain knowledge in …

Develop An Education Program Related To Evidence-Based Strategies Nurses Can Use To Decrease Medication Errors In A Nursing Home, Ann N. Akwaraonwu

Walden Dissertations and Doctoral Studies

These medication errors have posed an immense threat to patient safety, regulatory compliance, and staff confidence in healthcare. Therefore, the improved understanding of nursing staff and reduction in medication error rates required targeted education of nursing staff, thus the basis upon which this quality improvement project was implemented at a nursing home facility located in the Northeastern United States. This evidence-based intervention was developed from feedback that indicated a gap in knowledge on best practices related to the administration of medication among nursing staff. These were eight in number: registered nurses, licensed practical nurses, and certified nursing assistants, who had …

Tmic-58. Leveraging Viro-Immunotherapy By Targeting Igf2-Igf1r Signaling, Minhye Noh, Jin Muk Kang, Grace Nguyen, Ji Seon Shim, Alberto J. Bueso-Perez, Sara Murphy, Kimberly A. Rivera-Caraballo, Yoshihiro Otani, Eun Ju Kim, Seung-Hee Yoo, Yuanqing Yan, Yeshavanth Banasavadi-Siddegowda, Hiroshi Nakashima, E Antonio Chiocca, Balveen Kaur, Zhongming Zhao, Tae Jin Lee, Ji Young Yoo

Faculty, Staff and Student Publications

While an FDA-approved oncolytic herpes simplex-1 virus (oHSV) has shown therapeutic promise with superior safety, accumulating clinical data revealed that its therapeutic efficacy is observed in a small subset of patients. Here, we show that NFκB-mediated Insulin-like Growth Factor 2 (IGF2)/Insulin-like Growth Factor-1 Receptor (IGF1R) signaling pathway as a key modulator for oHSV therapy-mediated tumor resistance. RNA sequencing on the oHSV-infected primary glioblastoma (GBM) and breast cancer (BC) cells identified IGF2 as one of the top 10 upregulated secretomes. Transcriptomic analysis also revealed significant upregulation/enrichment of genes related to IGF2-IGF1R-MAPK pathway in oHSV-treated tumor cells. Infection with oHSV in GBM …

Examining Ptsd Prevalence Among Underserved Populations In The Integrated Community Mental Health Setting 2019 To 2022, Siran Koroukian, Stephen Zyzanski, Kurt C. Stange

Faculty Scholarship

Background: The prevalence of Post Traumatic Stress Disorder (PTSD) has been rising since the start of the COVID-19 pandemic, and affects females, sexual and gender minorities, and individuals with social risks at higher rates. Objective: This study examines if the prevalence of PTSD increased from 2019 to 2022 among patients who received care in a national network of safety-net, community-based health centers with integrated behavioral health programs that serve patients at high risk for PTSD. Methods: We analyzed electronic health record data from patients with 1 or more behavioral health visits during 2019 to 2022 using repeated cross-sectional data to …

Effectiveness Of Mailed Outreach And Patient Navigation To Promote Hcc Screening Process Completion: A Multicentre Pragmatic Randomised Clinical Trial, Amit G Singal, Manasa Narasimman, Darine Daher, Sruthi Yekkaluri, Yan Liu, Minjae Lee, Vanessa Cerda, Aisha Khan, Karim Seif El Dahan, Jennifer Kramer, Purva Gopal, Caitlin Murphy, Ruben Hernaez

Faculty, Staff and Students Publications

Background: Hepatocellular carcinoma (HCC) is plagued by failures across the cancer care continuum, leading to frequent late-stage diagnoses and high mortality. We evaluated the effectiveness of mailed outreach invitations plus patient navigation to promote HCC screening process completion in patients with cirrhosis.

Methods: Between April 2018 and September 2021, we conducted a multicentre pragmatic randomised clinical trial comparing mailed outreach plus patient navigation for HCC screening (n=1436) versus usual care with visit-based screening (n=1436) among patients with cirrhosis at three US health systems. Our primary outcome was screening process completion over a 36-month period, and our secondary outcome was the …

Epidemiology Of Β-Blocker Use Among Critically Iii Patients During And After Septic Shock, Stuthi Iyer, Jason N Kennedy, Peter C Nauka, Mourad H Senussi, Christopher W Seymour

Faculty, Staff and Students Publications

No abstract provided.

Characteristics Of Exacerbators In The Us Bronchiectasis And Ntm Research Registry: A Cross-Sectional Study, Nicole C. Lapinel, Radmila Choate, Timothy R. Aksamit, Joseph Feliciano, Kevin L. Winthrop, Andreas Schmid, Sebastian Fucile, Mark L. Metersky

School of Medicine Faculty Publications

BACKGROUND: Exacerbations of noncystic fibrosis bronchiectasis (bronchiectasis) are associated with reduced health-related quality of life and increased mortality, likelihood of hospitalisation and lung function decline. This study investigated patient clinical characteristics associated with exacerbation frequency. METHODS: A cross-sectional cohort study of patients ≥ 18 years with bronchiectasis enrolled in the US Bronchiectasis and Nontuberculous Mycobacteria (NTM) Research Registry (BRR) September 2008-March 2020. Patients were stratified by exacerbation frequency in their 2 years before enrolment. Patient demographics, respiratory symptoms, healthcare resource utilisation, microbiology, modified bronchiectasis severity index (mBSI) and select comorbidities were collected at enrolment. Patient characteristics associated with exacerbation frequency …

Impact Of Socioeconomic Deprivation On Care Quality And Surgical Outcomes For Early-Stage Non-Small Cell Lung Cancer In United States Veterans, Steven Tohmasi, Brendan T Heiden, Nikki E Rossetti, Ana A Baumann, Theodore S Thomas, Su-Hsin Chang, Nahom Seyoum, Yan Yan, Whitney S Brandt, Bryan F Meyers, Benjamin D Kozower, Varun Puri, Et Al.

2020-Current year OA Pubs

No abstract provided.

Immunofluorescence Use And Techniques In Glomerular Diseases: A Review, Nidia Messias

2020-Current year OA Pubs

BACKGROUND: Immunofluorescence (IF) studies play an essential role in the evaluation of medical renal biopsies. Particularly, in the study of renal glomerular diseases, where it provides fundamental data for the diagnosis, classification, and etiology of the glomerular pathologies. Diverse techniques may be used to optimize the utilization of IF studies, from variations on the test methodologies to expertise on the interpretation of the results and knowledge of potential pitfalls.

SUMMARY: This manuscript presents a brief review on the history of IF and its utilization in kidney pathology, followed by a description of the IF methods, including the use of IF …

Length Of Hospital And Intensive Care Unit Stay In Patients With Invasive Candidiasis And/Or Candidemia Treated With Rezafungin: A Pooled Analysis Of Two Randomised Controlled Trials, Patrick M Honoré, Matteo Bassetti, Oliver A Cornely, Herve Dupont, Jesús Fortún, Marin H Kollef, Peter Pappas, John Pullman, Jose Vazquez, Inga Bielicka, Sara Dickerson, Nick Manamley, Taylor Sandison, George R Thompson

2020-Current year OA Pubs

BACKGROUND: Invasive candidiasis/candidemia (IC/C) is associated with a substantial health economic burden driven primarily by prolonged hospital stay. The once-weekly IV echinocandin, rezafungin acetate, has demonstrated non-inferiority to caspofungin in the treatment of IC/C. This paper reports a post hoc pooled exploratory analysis of length of stay (LoS) for hospital and intensive care unit (ICU) stays in two previously published clinical trials (ReSTORE [NCT03667690] and STRIVE [NCT02734862], that compared rezafungin with daily IV caspofungin (stable patients in the caspofungin group who met relevant criteria could step down to fluconazole after 3 days or more).

METHODS: LoS outcomes were analysed descriptively …

Collaboration Strategies Affecting Implementation Of A Cross-Systems Intervention For Child Welfare And Substance Use Treatment: A Mixed Methods Analysis, Emmeline Chuang, Byron J Powell, Et Al.

2020-Current year OA Pubs

BACKGROUND: Collaboration strategies refer to policies and practices used to align operations and services across organizations or systems. These strategies can influence implementation of cross-system interventions focused on improving integration of care, but remain under-specified and under-examined. This study identifies collaboration strategies and the conditions under which they affected implementation of Sobriety Treatment and Recovery Teams (START), an evidence-based intervention focused on integrating child welfare and behavioral health services for families involved with both systems.

METHODS: Our study sample included 17 county child welfare agencies that implemented START. Data on collaboration strategies and organizational context were obtained from key informant …