Medicine and Health Sciences Commons^™

Efficacy And Safety Profile Of The Maternal Rsv Vaccine, Abrysvo, Dhanvi Patel

HCA-NSU MD Research Day

Efficacy and safety profile of the maternal RSV vaccine, Abrysvo Dhanvi Patel1, Jyotsna Chawla2, Cyril Blavo3 Department of Medicine, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Clearwater, USA Department of Foundational Sciences, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Clearwater, USA Department of Public Health, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Clearwater, USA Abstract: Objective: To study the vaccine efficacy and safety of the FDA-approved maternal respiratory syncytial virus (RSV) vaccine, Abrysvo, manufactured by Pfizer. Background: RSV-associated lower respiratory infections are the leading cause of hospitalizations in …

A Systematic Review Of Surgical Thyroid Storm, Skendi Lile, Vicky Zhang Md, Mohammadali Shoja Md

HCA-NSU MD Research Day

Objective. This systematic review was performed to highlight complications in non-thyroid surgeries amongst patients with undiagnosed hyperthyroidism. Background. Surgical thyroid storm can pose an emergent operative and postoperative complication that mimics the presentation of myocardial infarction, pulmonary embolism, and cerebrovascular accidents. This disease process can be elicited in both thyroid and non-thyroid surgeries and the diagnosis of such pathology can be difficult. In this review, we have reviewed the literature and analyzed cases of thyroid storms in non-thyroid operations. Methods. This systematic review utilized the PRISMA protocol and articles were obtained via Medline/PubMed, EMBASE, and WoS. Key phrases were used …

Emerging Diagnostics And Therapeutics For Non-Alcoholic Fatty Liver Disease, Kiarra Krulikowski, Jake Darbhanga, Suzanne Riskin

HCA-NSU MD Research Day

Introduction: The obesity epidemic has pushed fatty liver disease to the forefront of the 21st century. Disease identification can be done invasively with a liver biopsy or noninvasively through elastography and measurements of biomarkers. Presently, there are no FDA-approved drugs on the market to treat the disease. Alternative medicinal treatments have been investigated, which include altering the intestinal microbiota and consuming anti-inflammatory, herbal-based, vitamin-based, and plant-based medications. Methods: In this study, multiple databases were used to identify articles pertaining to fatty liver disease (FLD). All articles gathered from the databases were peer-reviewed and less than 10 years old to ensure …

Nosebleed No More: Recognizing And Diagnosing Factor Viii Inhibitor, Salam Harb, Leidy Huie Martinez Md, Jose Alvarado Md, Ajit Koli Do, Hazem Nasef Ms4

HCA-NSU MD Research Day

Acquired hemophilia is a condition characterized by the unexpected onset of severe bleeding due to an issue with coagulation factors. Typically, this disorder results from the production of autoantibodies against the Factor VIII coagulation factor. Although acquired hemophilia is an extremely rare condition, with an annual incidence of just 1.5 cases per million, it is crucial to recognize and understand it. This is because diagnosing this disorder is intricate, and if left undiagnosed and untreated, it can lead to high levels of morbidity and mortality. This case stands out as the condition typically targets older adults, with around 80% of …

Case Study: Navigating The Complexities Of Variegate Porphyria, Derek Weimer, Tanya Ramadoss, Una Milovanovic, Sydney Risman, Amber Fouts, Syed Hakeem Shah Md

HCA-NSU MD Research Day

Introduction. Variegate Porphyria (VP) is a rare autosomal dominant disorder characterized by mutations in the protoporphyrinogen oxidase (PPOX) gene, leading to dysfunctional heme biosynthesis. The clinical manifestations of VP are highly variable, including significant neurovisceral symptoms and cutaneous photosensitivity. This variability reflects the disease's ability to often go undiagnosed, especially in pediatric populations where the disease is not frequently seen in clinical practice. Case Presentation. This case study focuses on a 12-year-old male who presented with persistent photosensitivity, painful blistering, severe abdominal pain, and dark-colored urine. Despite normal renal and liver serology testing, elevated porphyrin levels in both urine and …

Common And Atypical Hand Infections: A Pictorial Review, Una Milovanovic, Melissa Ricardo, Drew Johnston, Parker Melnick, Jonathan Melnick, Gary Schwartz Md

HCA-NSU MD Research Day

Objective: To provide a comprehensive visual guide to diagnosing and managing various hand infections, emphasizing the correlation between clinical signs and imaging findings for accurate diagnosis and treatment. Background: Hand infections present a clinical challenge due to diverse etiologies and presentations. Early and accurate diagnosis is essential to prevent complications and optimize treatment. This review provides clinicians with a concise summary of key visual findings, radiographic images, clinical features, and management strategies for hand infections. Methods: This review is based on a retrospective analysis of clinical cases involving hand infections of various etiologies. The cases include clinical photographs, X-rays, and …

Flexor Tenosynovitis Of The Wrist And Hand Due To Non-Tuberculous Mycobacteria, Mariafe Reyes, Tatevik Malisetyan, Skylar Harmon, Mohammadali M. Shoja Md, Gary B. Schwartz Md

HCA-NSU MD Research Day

Title: Flexor Tenosynovitis of the Wrist and Hand Due to Non-tuberculous Mycobacteria Authors: Mariafe Reyes1,Tatevik Malisetyan1, Skylar Harmon1, Mohammadali M. Shoja, MD1 Gary B. Schwartz, MD1 1Nova Southeastern University Dr. Kiran C. Patel College of Allopathic Medicine, Fort Lauderdale, USA INTRODUCTION: Non-tuberculous mycobacteria (NTM) are a group of bacteria, including Mycobacterium marinum, Mycobacterium kansasii, and Mycobacterium avium intracellulare (MAI), that usually exist in the soil and water sources. The most common site of infection is the lungs, but extra-pulmonary involvement of the skin and rarely the musculoskeletal (MSK) system does occur, especially the hands and wrists. CASE PRESENTATION: A 45-year-old, …

Recent Developments In Tirzepatide's Role In Reducing Cardiovascular Disease Risk Factors In Adults With Type 2 Diabetes, Talaya Jones, Zaneh Kahook, Carina Bryan, Mayur Parmar

HCA-NSU MD Research Day

Objective: This literature review aims to investigate recent developments in tirzepatide’s ability to lessen CVD risk factors for adults with increased risk of major adverse cardiovascular events. Background: Tirzepatide is an FDA - approved medication primarily used to treat adults with type 2 diabetes mellitus (T2DM) by reducing A1C and chronic weight management, however its efficacy for reducing CVD risk factors is under examination. Methods: This review synthesizes data from recent early findings published by the pharmaceutical company, which has not yet undergone peer review, alongside existing literature on tirzepatide. Additional sources were identified through a systematic search of PubMed, …

Triaging The Clinical Dilemma Of A Suicidal Attempt With Sotalol Overdose Presenting With Ventricular Tachycardia, Asystole And Torsades De Pointes, Ambika Kapil, Sahara Abdelmoneim, Manuel De Cruz, Odalys Frontela, Sabas Gomez, Ambika Kapil

HCA-NSU MD Research Day

INTRODUCTION: Beta-blockers are widely prescribed for managing various conditions, including hypertension, heart failure, ischemic heart disease, arrhythmias, and off-label uses for tremors, migraines, and anxiety. They are classified into cardioselective and non-cardioselective. Although generally well-tolerated with mild side effects, beta-blocker overdose can lead to severe cardiac instability and potentially fatal outcomes. CASE PRESENTATION: To illustrate, we present a 59-year-old woman who arrived at the Emergency Room with anxiety after ingesting 15 Sotalol tablets (120 mg). Per the husband, the patient exhibited paranoid ideas for the past 3 days. The review of systems was negative. Vitals on admission: Blood Pressure 128/76 …

Revisiting The Marginal Artery Of Drummond: A New Insight Into The Anatomy Of Colonic Arterial Supply, Jeams Richard Costa, Michael Kitiashvili, Jack Stensland, Mohammadali Shoja

HCA-NSU MD Research Day

OBJECTIVE: This study was conducted to challenge the assumption that the marginal artery (MA) of Drummond is fully continuous. BACKGROUND: The MA is a crucial arterial anastomosis that runs along the inner margin of the colon. Despite its importance, the continuity of the MA has been insufficiently evaluated in the literature. METHODS: We dissected the mesentery in 18 cadavers to explore the formation and identify any areas of discontinuity in the MA. RESULTS: Varying degrees of MA discontinuity was observed among individuals. Complete continuity of the MA was observed in only one case. In one specimen, the MA was completely …

Hans Holbein's Portrait Of Henry Viii: England's Own Personal Jesus, Amy Pitsor

Best Integrated Writing

Pitsor explores the possibility that Holbein’s late-stage change in the composition of the portrait from a three-quarter view of Henry to a frontal view held a motive to present Henry as the head of the newly established Church of England and as equal to the pope, and possibly to Christ himself.

La Falta De Los Supermercados En El Oeste De Dayton: Cómo Obtienen Los Estudiantes Comida Fresca En Los Desiertos Alimentarios (Un Ensayo Expositivo-Argumentativo, Catherine Iacobacci

Best Integrated Writing

After having learned about how poverty can affect children’s educational outcomes in one of her classes, Iacobacci wanted to learn more about how the issue affected the area where she lived and went to school. What she found out was incredibly shocking, and only furthered the idea that students are struggling with opportunity gaps, not achievement ones. Unfortunately, due to discriminatory loan practices from long ago, children from the 21st century are suffering physically, emotionally, and academically.

The Journey Within: My Travel Journel, Devonique Jones

Best Integrated Writing

This project is a multigenre research exploration that delves into Jones's personal journey of self discovery and growth during her first solo trip.

Investigation Of Ndv In Southern African Waterfowl Reveal Insightful Geographic And Biodiversity Trends To Help Contain The Virus, Lauren Goodwill

Best Integrated Writing

This study assesses the infection rates and trends of Newcastle disease in southern African waterfowl, a project carried out by Emily Murphy in Dr. Jeffrey Peters’ laboratory

Analysis Of The Integration Of Race And Cultural Concordant Doulas Into The Birth Experience Of African American Women, Cherissa Garcia

Best Integrated Writing

Garcia's study looks at how integrating race and cultural-concordant doulas into the birth experience of African American women would impact outcomes. She found similar studies that provided strong evidence to support doula integration. However, most did not select study populations that appropriately reflected the African American women at increased risk of poor outcomes. As a result, Garcia designed a study that looked at race and cultural concordance between doulas and patients from a wide range of SES backgrounds and varying degrees of pregnancy risk.

The Foreigner In Our Midst: Jewish Rights Debates In Revolutionary France, William Evans

Best Integrated Writing

The debates surrounding Jewish rights during the French Revolution concerned many of the same subjects that divide the Western world today. The fear of the other, immigration as a political tool, and the disagreements over assimilation are all subjects which feature prominently today. In this essay Evans sets out to explore these debates while fairly assessing the historical informants.

Junebug In January: A Novel Excerpt, Hannah Carson

Best Integrated Writing

This section of Junebug in January is the beginning of a much longer story that follows eighteen-year-old June and her small family as she attempts to survive the harsh reality of living in the era of the Great Depression and her attempts to survive her Papa’s tasks for her. This story challenges the boundaries of family loyalty, investigates the concept of “saving yourself,” and explores the limits of redemption.

Best Integrated Writing Fall 2024 - Complete Edition, Wright State University School Of Humanities And Cultural Studies, Kristie Mckiernan, Tracy Smith

Best Integrated Writing

Best Integrated Writing includes excellent student writing from Integrated Writing courses taught at Wright State University.

Comparison Of Bacterial Meningitis Complicated By Stroke In Adults Versus Children: A Scoping Review, Isabella Cook, Apurva Ramanujam, Afrida Sara, Arjun Nair, Sabina Chon, Erick Boldt, Miranda Londono, Alan Wang, Sarah Mohamed, Shivani Dave, Yuri Zagvazdin

HCA-NSU MD Research Day

Title: Comparison of Bacterial Meningitis Complicated by Stroke in Adults versus Children: A Scoping Review Authors: Isabella Cook, OMS-II; Apurva Ramanujam, OMS-II; Afrida Sara, OMS-II; Arjun Nair, OMS-II; Sabina Chon, OMS-II, M.S.; Erick Boldt, OMS-II; Miranda Londono, OMS-II; Alan Wang, OMS-II, M.A.; Sarah Mohamed, OMS-II; Shivani Dave, OMS-II; Yuri Zagvazdin, Ph.D. Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Davie, Florida Background: Bacterial meningitis (BM) complicated by stroke in adults include distinct manifestations compared to children. Although there are notable differences in presentations between children and adults, there is limited availability in research defining a protocol for …

When Aml Strikes Twice: A Case Of Acute Myeloid Leukemia With Concurrent Myopericarditis And Acute Pancreatitis, Veronica Benitez, Gabriella A. Morey, Veronica Benitez, Roberto H. Ruiz

HCA-NSU MD Research Day

Introduction: Acute myeloid leukemia (AML) is a hematological malignancy characterized by the proliferation of undifferentiated hematopoietic stem cells, leading to symptoms like fatigue, fever, and bleeding. While AML can infiltrate various organs, myocardial and pancreatic involvement are extremely rare, with myopericarditis and acute pancreatitis being particularly uncommon. Case Description: A 72-year-old hispanic female with a history of pancreatitis and autoimmune disorders presented with worsening lower abdominal pain, dysuria, nausea, and vomiting. Her pancreatitis resolved, but she subsequently developed chest pain and was diagnosed with acute pericarditis. Her elevated white blood cell count, predominantly monocytic, led to the diagnosis of AML …

Intestinal Protozoan Parasites & Gut Microenvironment Disruption In Crohn's Disease, Jowana Ghazzawi, Jyotsna Chawla Assistant Professor, Microbiology, Cyril Blavo

HCA-NSU MD Research Day

Crohn’s Disease (CD) is a chronic inflammatory disorder that can affect any part of the gastrointestinal tract. Despite the unknown etiology, a combination of genetic, environmental, bacterial, viral, and other microbial factors are believed to play a role in its development. While the impact of bacterial agents on CD has been extensively studied, the influence of intestinal protozoan parasites is an emerging area of interest. This study investigates the role of these parasites in disrupting the gut microenvironment and their contribution to the pathological and physiological changes observed in CD. Understanding these interactions may offer new insights into disease mechanisms …

The Role Of Kctd13 In Androgen Receptor Ubiquitination​, Faith Abraham, Ahmed Chahdi, Phd, Carolina Jorgez, Phd, Abhishek Seth

HCA-NSU MD Research Day

The Role of KCTD13 in Androgen Receptor Ubiquitination Faith Abraham1, Ahmed Chahdi, PhD2, Caroline Jorgez, PhD3, and Abhishek Seth, MD2 1Class of 2024, Dr. Kiran C. Patel College of Osteopathic Medicine, 2Urology, Nemours Children’s Hospital, Orlando, FL 3Urology, Baylor College of Medicine, Houston, TX Objective: This study was conducted to determine the effect of the KCTD13 gene on major protein effectors of common genitourinary (GU) defects. Background: Hypospadias, characterized by the ventral positioning of the urethral opening, occurs in approximately 1 out of 125 live births. Cryptorchidism, or undescended testes (UDT), is the most common GU birth defect, affecting around …

Nourishing Skin Health: The Impact Of A Balanced Diet On Chronic Inflammatory Skin Conditions, Archana Banda

HCA-NSU MD Research Day

Objective: This study was conducted to determine the influence a balanced diet has on the outcome of specific dermatologic conditions notably psoriasis, atopic dermatitis, and rosacea. Background: Nutritional status is pivotal in shaping holistic wellness, which extends to skin health. Adequate nutrition can prevent the worsening of inflammatory conditions. Methods: A literature review was conducted to analyze how specific dietary habits for selected chronic inflammatory cutaneous conditions influence the presentation and overall clinical outcome. Results: The analysis indicates a higher incidence of flare-ups with diets heavily consisting of carbohydrates, red meat, alcohol, and fats. Specific diets, such as the Western …

Lifestyle Effects On An Unusual Presentation Of Syncope: A Case Report, Rishma Gattu, Nisarg Shah, Ramya Ravulapalli, Vania Rodriguez, Gary Merlino

HCA-NSU MD Research Day

Introduction: This case study explores a unique presentation of syncope with a multifactorial etiology and discusses the impact of lifestyle behaviors on syncope exacerbation. Scant literature exists on behavioral modifications affecting cardiogenic responses. Case Presentation: We present a 53 year old Hispanic male with a past history of palpitations and chronic marijuana use coming to the emergency department (ED) with three episodes of sudden loss of consciousness that occurred after starting his job as a night shift worker, which led to severe chronic sleep deprivation. These episodes lacked prodromal (chest pain, shortness of breath, palpitations, diaphoresis) and postictal (drowsiness, nausea, …

Crush Injuries: A Review And Case Series, Daniel Gonzales-Portillo, Maria Fe Reyes, Josef Maselli, Gary B. Schwartz

HCA-NSU MD Research Day

Crush Injuries: A Review and Case Series Daniel Gonzales-Portillo1, Maria Fe Reyes1, Josef Maselli1, Gary Schwartz1 1Nova Southeastern University Dr. Kiran C Patel College of Allopathic Medicine, Fort Lauderdale, USA Objective: The goal was to discern patterns between different presentations of crush injuries to the hand and what treatment decisions lead to improved functional outcomes and increased patient satisfaction. Background: The compressive force from crush injuries in this small region of the body causes extremely variable damage to tissues, complicating treatment due to difficulty in staging and precise identification of structures capable of recovery. The timeline and mechanism of injury …

Impact Of Proxymetacaine On The Dynamics Of Cyclopentolate In White 6- To 7-Year-Olds, Megan Doyle, Veronica O'Dwyer, Siofra Harrington

Articles

Purpose

This study compared the efficacy of cyclopentolate hydrochloride at 10-, 20- and 30-min post-instillation in White 6- to 7-year-olds, with and without prior instillation of proxymetacaine hydrochloride. The primary aim was to determine if accurate autorefraction values can be obtained sooner than the current standard of 30-min post-cycloplegia. The secondary aim was to investigate whether proxymetacaine hydrochloride enhances the efficiency of cyclopentolate.

Methods

Participants were 112 White 6- to 7-year-olds from the Child Eye Health Study. The right eye received 0.5% proxymetacaine hydrochloride and 1.0% cyclopentolate hydrochloride, and the left eye received only 1.0% cyclopentolate hydrochloride. Non-cycloplegic and cycloplegic …

Effects Of Sex And Estrous Cycle On Extended-Access Oxycodone Self-Administration And Cue-Induced Drug Seeking Behavior, Bhumiben P Patel, Jessica A Loweth

Rowan-Virtua School of Osteopathic Medicine Departmental Research

INTRODUCTION: Increasing evidence indicates that sex is a factor that impacts the abuse liability and relapse vulnerability of prescription opioids like oxycodone. However, while women are more likely than men to be prescribed and to use these drugs, the impact of sex and ovarian hormones on prescription opioid use and relapse vulnerability remains unclear. Accurately assessing these measures is complicated by the fact that chronic opioid exposure can lower ovarian hormone levels and cause cycle irregularities.

METHODS: Adult male and female Sprague-Dawley rats self-administered oxycodone (0.1 mg/kg/infusion) under extended-access conditions (6 h/day, 10 days) followed by forced abstinence. Separate groups …

Fpa (Ylan) Is An Iron(Ii) Binding Protein That Functions To Relieve Fur-Mediated Repression Of Gene Expression In, Jeffrey M Boyd, Kylie Ryan Kaler, Karla Esquilín-Lebrón, Ashley Pall, Courtney J Campbell, Mary E Foley, Gustavo Rios-Delgado, Emilee M Mustor, Timothy G Stephens, Hannah Bovermann, Todd M Greco, Ileana M Cristea, Valerie J. Carabetta, William N Beavers, Debashish Bhattacharya, Eric P Skaar, Lindsey N Shaw, Timothy L Stemmler

Cooper Medical School of Rowan University Departmental Research

Iron (Fe) is a trace nutrient required by nearly all organisms. As a result of the demand for Fe and the toxicity of non-chelated cytosolic ionic Fe, regulatory systems have evolved to tightly balance Fe acquisition and usage while limiting overload. In most bacteria, including the mammalian pathogen Staphylococcus aureus, the ferric uptake regulator (Fur) is the primary transcriptional regulator controlling the transcription of genes that code for Fe uptake and utilization proteins. Fpa (formerly YlaN) was demonstrated to be essential in Bacillus subtilis unless excess Fe is added to the growth medium, suggesting a role in Fe homeostasis. …

Clinical Practice Guideline For Evidence-Based Patient Appointment Reminders, Rohan Matthews

Walden Dissertations and Doctoral Studies

Clinical practice guidelines (CPGs) are health care interventions used for best care outcomes. With this CPG project, I addressed a practice gap regarding the lack of a systematic approach to patient appointment reminders that resulted in disruption to patient health maintenance in an outpatient community clinic setting. Community and population health are improved with preventative care, wellness, and appropriate health maintenance measures. The practice-focused question central to this CPG was: Will a guideline on patient reminders designed to reduce the frequency of missed appointments in a clinic setting, be approved by a panel of clinical experts for future implementation? The …

Predictors Of Study Dropout In Cognitive-Behavioural Therapy With A Trauma Focus For Post-Traumatic Stress Disorder In Adults: An Individual Participant Data Meta-Analysis, Simonne Wright, Eirini Karyotaki, Pim Cuijpers, Jonathan Bisson, Davide Papola, Anke B Witteveen, Sudie E Back, Dana Bichescu-Burian, Liuva Capezzani, Marylene Cloitre, Grant J Devilly, Thomas Elbert, Marcelo Mello, Julian D Ford, Damion Grasso, Pedro Gamito, Richard Gray, Moira Haller, Nigel Hunt, Rolf J Kleber, Julia König, Claire Kullack, Jonathan Laugharne, Rachel Liebman, Christopher William Lee, Jeannette Lely, John C Markowitz, Candice Monson, Mirjam J Nijdam, Sonya B Norman, Miranda Olff, Tahereh Mina Orang, Luca Ostacoli, Nenad Paunovic, Eva Petkova, Patricia Resick, Rita Rosner, Maggie Schauer, Joy M Schmitz, Ulrich Schnyder, Brian N Smith, Anka A Vujanovic, Yinyin Zang, Érica Panzani Duran, Francisco Lotufo Neto, Soraya Seedat, Marit Sijbrandij

Faculty, Staff and Student Publications

Background: Available empirical evidence on participant-level factors associated with dropout from psychotherapies for post-traumatic stress disorder (PTSD) is both limited and inconclusive. More comprehensive understanding of the various factors that contribute to study dropout from cognitive-behavioural therapy with a trauma focus (CBT-TF) is crucial for enhancing treatment outcomes.

Objective: Using an individual participant data meta-analysis (IPD-MA) design, we examined participant-level predictors of study dropout from CBT-TF interventions for PTSD.

Methods: A comprehensive systematic literature search was undertaken to identify randomised controlled trials comparing CBT-TF with waitlist control, treatment-as-usual or another therapy. Academic databases were screened from conception until 11 January …