Medicine and Health Sciences Commons^™

Mental Health Prevention And Treatment Programs For Infants Experiencing Homelessness: A Systematic Review, Megan M Hare, Taylor D Landis, Melissa Hernandez, Paulo A Graziano

Faculty, Staff and Student Publications

Experiencing homelessness in infancy has been linked to negative physical and mental health outcomes. Parental well-being and the parent-infant relationship can also be negatively impacted by experiencing homelessness. While numerous parent-based infant mental health programs have been identified by a recent review, the goal of this study was to further determine the extent to which these existing programs were developed and/or examined with at-risk populations such as families experiencing homelessness. Out of 60 programs identified by Hare et al., in press, only three had been implemented specifically in shelter settings with infants 0-12 months (Parent-Infant Psychotherapy, New Beginnings, and My …

Dual Suppression Of Glossina Pallidipes Using Entomopathogenic Fungal-Based Biopesticides And Sterile Insect Technique, Fidelis L.O. Ombura, Adly M.M. Abd-Alla, Komivi S. Akutse, Steven Runo, Paul O. Mireji, Rosemary Bateta, Joseck E. Otiwi, Inusa J. Ajene, Fathiya M. Khamis

All Peer-Reviewed Publications

Tsetse flies and trypanosomosis significantly impact bovine production and human health in sub-Saharan Africa, exacerbating underdevelopment, malnutrition, and poverty. Despite various control strategies, long-term success has been limited. This study evaluates the combined use of entomopathogenic fungi (EPF) and the sterile insect technique (SIT) to combat tsetse flies. Eleven EPF isolates were tested against teneral males of Glossina pallidipes, focusing on mortality rates, radial growth, and impacts on fly fitness. Temperature effects on conidial growth, sporulation, and spore yield of SIT-compatible/tolerant strains were also assessed. The fungal isolates significantly influenced mortality rates in both unirradiated and irradiated (SIT-treated) males (p <  0.0001). Metarhizium anisopliae strains ICIPE 20, ICIPE 32, ICIPE 41, ICIPE 62, ICIPE 78, and Beauveria bassiana ICIPE 603 showed higher SIT compatibility/tolerance with LT50 values of 11–30 days, compared to other more virulent isolates with LT50 values of 4–9 days. Temperature significantly affected the radial growth of SIT-compatible EPF strains (p <  0.0001), with M. anisopliae ICIPE 78 exhibiting the fastest conidia growth at 25°C. Spore yield varied significantly across temperatures (15–40°C), and the thermal range for conidia germination of SIT-compatible strains was 8.1–45.4°C, with an optimal range of 26.7–31.1°C. Moreover, infected unirradiated females and irradiated males (donors) successfully transmitted conidia to untreated flies (receivers) without significant differences in survival rates (p = 0.6438) and no observed sex dimorphism. Our findings highlight the potential of combining EPF and SIT as a novel dual approach that could effectively and synergistically suppress tsetse fly populations.

Tissue-Specific Localization Of Tick-Borne Pathogens In Ticks Collected From Camels In Kenya: Insights Into Vector Competence, Rua Khogali, Armanda Bastos, Joel L. Bargul, Dennis Getange, James Kabii, Daniel Masiga, Jandouwe Villinger

All Peer-Reviewed Publications

Background: Tick-borne pathogen (TBP) surveillance studies often use whole-tick homogenates when inferring tick-pathogen associations. However, localized TBP infections within tick tissues (saliva, hemolymph, salivary glands, and midgut) can inform pathogen transmission mechanisms and are key to disentangling pathogen detection from vector competence. Methods: We screened 278 camel blood samples and 504 tick tissue samples derived from 126 camel ticks sampled in two Kenyan counties (Laikipia and Marsabit) for Anaplasma, Ehrlichia, Coxiella, Rickettsia, Theileria, and Babesia by PCR-HRM analysis. Results: Candidatus Anaplasma camelii infections were common in camels (91%), but absent in all samples from Rhipicephalus pulchellus, Amblyomma gemma, Hyalomma dromedarii, …

Overcoming The Unseen: Understanding Diverse Canadian Workers’ Well-Being During The Beginning Of The Coronavirus Pandemic, Tyler M. Pacheco

Theses and Dissertations (Comprehensive)

Canadian workers were severely affected by the onset of the coronavirus (COVID-19) pandemic. The rapid spread of the pathogen across Canada resulted in several work-related consequences (e.g., temporary/indefinite layoffs and business closures, mandatory working-from-home) that could have impacted workers’ well-being during this turbulent period. Research available at the start of this dissertation process, and even more recently published studies, primarily explored general trends in workers’ negative well-being during COVID-19, not examining the distinct realities that diverse workers, including more marginalized ones, may have experienced. Across three manuscripts, several theories from diverse disciplines (positive, developmental, community, and industrial-organizational psychology, public health) …

A Comparative In Vitro Investigation Of Rainbow Trout Vig-3 And Human Isg15, Kristof Jenik, Sarah J. Poynter, Shanee Herrington-Krause, Kayla Samms, Nichole Sanchez Diaz, Stephanie J. Dewitte-Orr, Tania Rodriguez-Ramos, Brian Dixon, Adebisi Sanyaolu, Tamiru Alkie, Bryce M. Warner, Nikesh Tailor, Shawna Semple

Theses and Dissertations (Comprehensive)

The aquaculture industry is a big part of the global economy, supplying food and supporting many livelihoods, yet it faces formidable challenges from diverse aquatic pathogens, especially viruses. Effective antiviral treatments are lacking for both humans and economically significant farmed fish like rainbow trout (Oncorhynchus mykiss). When viruses invade host cells, pattern recognition receptors detect viral components, initiating intracellular signaling and type I interferon (IFN-I) production. IFN-I triggers interferon-stimulated genes (ISGs) that establish an antiviral state in infected and nearby cells, curbing viral spread. In rainbow trout, a particularly understudied ISG is viral hemorrhagic septicemia virus (VHSV)-induced gene 3 (vig-3), …

"Why Does This Have To Be So Hard?": Perinatal Experiences From An Ecological Systems Approach, Caitlin Senk

Antioch University Dissertations & Theses

This study examines the lived experience of the perinatal population to understand how they can be supported from the lens of different ecological systems and what counselors can do to better serve people with uteruses during their perinatal experience. Furthermore, this study aims to utilize an inclusive framework for capturing the perinatal experience of people with uteruses and to explore barriers and facilitators to care through an ecological systems framework. Fifteen participants who have experienced infertility, conception, pregnancy, miscarriage, childbirth, stillbirth, and postpartum were recruited through various means throughout the United States. Thematic analysis was used, with semi-structured interviews and …

Understanding The Experience Of Mothers In Higher Education During The Covid-19 Era, Shannan L. Engel

Antioch University Dissertations & Theses

This exploratory study aimed to understand the experience of mothers in higher education both during the COVID-19 pandemic and toward the end of restrictions. The population included academic mothers with children at home during the pandemic. Data was analyzed thematically by a team of researchers. The results generated six themes: (a) life changed suddenly, (b) remote work, school, and life, (c) unsupported, (d) sense of control, (e) support, and (f) positive aspects of COVID. These findings are important to the field of mental health counseling profession, supervision, and higher education because of the circumstances exemplified by the pandemic that highlight …

Emotions, Self-Efficacy, And Accountability For Antiracism In White Women Counselors, Lisa Wenninger

Antioch University Dissertations & Theses

Supporting the development of an antiracist identity in counselors could facilitate change toward equity, justice, and opportunity within the counseling profession and increase awareness of white counselors in working with clients of color. Understanding obstacles to and enablers of antiracist attitudes in white women counselors holds the potential to bring change to the profession as a whole, given their position in the majority. This quantitative study used instruments to assess white racial affects of white fear, anger, and guilt along with antiracist self-efficacy as influencing antiracist accountability in a sample of white women counselors in the United States (N = …

Developing Self-Evaluation Skills In Interprofessional Simulation Educators: A Multilevel Mixed-Methods Study, Dana G. Trottier

Antioch University Dissertations & Theses

This multilevel mixed methods investigation examines the experiences of developing self-evaluation skills for simulation fellows in an interprofessional simulation fellowship program. Interprofessional fellows (N = 12) and faculty (N = 4) engaged in a three-phase study using video-assisted learning tools to explore the differences in self-evaluation (perceived performance) and faculty evaluation (actual performance) in developing debriefing skills. For the quantitative component, fellows and faculty completed the DASH© tool to evaluate the quality of debriefing to help close the gaps between fellow self-evaluation and faculty evaluation. For the qualitative component, video-stimulated think-aloud and video-assisted debriefing the debriefer were utilized to understand …

Lead Poisoning In Children: A Preventable Disease, Heather Aaron

Antioch University Dissertations & Theses

Children lead poisoning disease causes irreversible neurological damage in children (Centers for Disease Control and Prevention [CDC], 2022). The effects are lifelong for the children poisoned and their families. A major cause of childhood lead poisoning is the ingestion of peeling paint in old homes. Leaded paint was banned by the federal government in 1978 (Mayo Clinic, 2022). Leaded paint is mostly found in dwellings constructed before 1978. The purpose of this study is to identify barriers, social justice parameters, and solutions to and for the eradication of childhood lead poisoning in Connecticut. The methodology used was a qualitative interview …

Experiences Of Counselors Working With Adolescents, Allison Bradford Chow

Antioch University Dissertations & Theses

This qualitative study aimed to examine the lived experience of clinical mental health counselors working with adolescents. Participants included pre-licensed (associate) or licensed counselors who predominately work with and have a strong preference for working with adolescent clients. Data was collected through individual interviews and analyzed with a descriptive-interpretative approach. Ten domains were identified as part of data analysis: (a) Understanding Adolescent Culture and Building a Therapeutic Alliance, (b) The Intersection of Counselor and Adolescent Emotions, (c) Transference and Countertransference, (d) Clinical Challenges and Barriers, (e) The Multifaceted Role of Parents, (f) Nuances of Confidentiality, (g) Adolescent Development and Strengths, …

Emdr Gaming Recovery And Insight Protocol (E-Grip): An Approach For Treating Video Game Addiction, Manjit Bath

Antioch University Dissertations & Theses

The prevalence of video game addiction has escalated with the advancement of digital technologies, posing significant psychological and social challenges. This dissertation introduces the eye movement desensitization and reprocessing (EMDR) Gaming Recovery and Insight Protocol (E-GRIP), a novel therapeutic approach designed to address the complexities of video game addiction. Grounded in the principles of EMDR therapy and incorporating insights into video game culture, E-GRIP aims to treat individuals struggling with problematic gaming behaviors by integrating their gaming experiences and preferences into the therapeutic process. The E-GRIP methodology extends the conventional EMDR framework by including an in-depth exploration of the client’s …

Therapeutic Interventions For Adolescents With Non-Epileptic Seizures, Noah Trantel

Antioch University Dissertations & Theses

Although there have been some studies that explore the lived experiences of adults with non-epileptic seizures, there have been limited studies that examine the lived experiences of adolescents and emerging adults with non-epileptic seizures. This qualitative study explored the experiences of emerging adults who had been diagnosed with non-epileptic seizures during adolescence. The study focused on specific interventions utilized in therapy that they found helpful, highlighted what their experiences were throughout their daily lives, and what treatment recommendations were provided. The research will also help guide parents, clinicians, and individuals with NES towards treatment recommendations. Eight participants completed an in-depth, …

Are They Well? Examining Emotional Intelligence Competencies Of Female College Athletes, Anne E. Funke

Antioch University Dissertations & Theses

In this dissertation, I explore the emotional intelligence (EQ) competencies of 19 female student-athletes at one Division III institution. College students are suffering from a collective brain health crisis in the aftermath of the COVID-19 pandemic (United States Department of Health and Human Services, 2021). Students’ social and emotional needs and skills have continued to steadily decline. Colleges have a responsibility to prioritize the social-emotional health of all students above performance and achievement. Student-athletes in particular face unique challenges and pressures that non-athlete students do not. Managing time commitments of athletic schedules and coursework, navigating publicity and increased attention, and …

The Anatomy Of Physician Fulfillment: Strategies Beyond Burnout, Brook Hale

Antioch University Dissertations & Theses

The persistent tension and power struggle between healthcare executives and physicians is a prevalent issue in healthcare organizations, often leading to a culture of organizational mistrust. This dynamic stems from perceived conflicting goals: executives are frequently seen as primarily focused on financial outcomes, while physicians are viewed as resistant to change. This study explored how physician fulfillment is experienced at work, with the ultimate goal of identifying potential interventions to bridge the gap between these groups. There is vast research and literature available regarding burnout in healthcare; this research focused on understanding what physicians find fulfilling in their work and …

Needs Assessment For Sexual Violence Trauma-Informed Care In The Dental Field, Joshua Garufi

Antioch University Dissertations & Theses

Trauma-informed care provides a framework for health care providers to more effectively treat their patients who have a history of trauma (Hamberger et al., 2019). Upon reviewing the literature, there is a paucity of research on trauma-informed care in the dental field. This research performed a needs assessment to determine if trauma-informed care is being implemented into the curriculum at a specific dental school, SUNY Buffalo. This research also inquired about residential dentist and faculty attitudes toward trauma-informed care being implemented in the dental field. Two short, original surveys were administered to residential dentists who recently graduated from the University …

Exploring Angiotensin Ii And Oxidative Stress In Radiation-Induced Cataract Formation: Potential For Therapeutic Intervention, Vidya P. Kumar, Yali Kong, Riana Dolland, Sandra R. Brown, Kan Wang, Damian Dolland, David Mu, Milton L. Brown

Department of Biomedical and Translational Sciences Faculty Publications

Radiation-induced cataracts (RICs) represent a significant public health challenge, particularly impacting individuals exposed to ionizing radiation (IR) through medical treatments, occupational settings, and environmental factors. Effective therapeutic strategies require a deep understanding of the mechanisms underlying RIC formation (RICF). This study investigates the roles of angiotensin II (Ang II) and oxidative stress in RIC development, with a focus on their combined effects on lens transparency and cellular function. Key mechanisms include the generation of reactive oxygen species (ROS) and oxidative damage to lens proteins and lipids, as well as the impact of Ang II on inflammatory responses and cellular apoptosis. …

From Pollution To Resource: Advancing Swine Waste Treatment In The Usa, Viney P. Aneja, Ryke Longest, Matias B. Vanotti, Ariel A. Szogi, Gudigopuram B. Reddy

Faculty Scholarship

Concentrated animal feeding operations (CAFOs) have led to environmental challenges, specifically waste management. Swine CAFOs generate large amounts of waste, requiring proper treatment to avoid air and water pollution. Conventional waste management technologies, such as lagoon and spray field systems, do not prevent air and water pollution impacts. Research for the past few decades led to recommendations for waste treatment technologies superior to lagoons and spray fields. Private environmental sustainability initiatives focused on reducing greenhouse gas emissions in the food supply chain have implemented biogas digester projects for capturing methane in covered swine lagoons to reduce greenhouse gas emissions. However, …

Modeling The Effect Of Observational Social Learning On Parental Decision-Making For Childhood Vaccination And Diseases Spread Over Household Networks, Tamer Oraby, Andras Balogh

School of Mathematical & Statistical Sciences Faculty Publications

In this paper, we introduce a novel model for parental decision-making about vaccinations against a childhood disease that spreads through a contact network. This model considers a bilayer network comprising two overlapping networks, which are either Erdős–Rényi (random) networks or Barabási–Albert networks. The model also employs a Bayesian aggregation rule for observational social learning on a social network. This new model encompasses other decision models, such as voting and DeGroot models, as special cases. Using our model, we demonstrate how certain levels of social learning about vaccination preferences can converge opinions, influencing vaccine uptake and ultimately disease spread. In addition, …

Use Of Hydroxychloroquine In Multidrug Protocols For Sars-Cov-2, Eleftherios Gkioulekas, Peter A. Mccullough

School of Mathematical & Statistical Sciences Faculty Publications

We review the available evidence supporting the use of hydroxychloroquine-based multidrug protocols in the treatment of COVID-19, in response to a recently published editorial in the Tasman Medical Journal.

Technoference In Parenting And Impacts On Parent–Child Relationships And Child Development, Brandon T. Mcdaniel Phd, Lisa Linder, Mariek M.P. Vanden Abeele, Alison K. Ventura, Sarah M. Coyne, Rachel Barr

Health Services and Informatics Research

“Technoference” is a term that describes how parent media use (e.g., phone use) can interfere with parent–child relationships and interactions. Research has shown technoference effects on parents and children ranging in age from infancy to adolescence, such as decreased parent responsiveness and adverse child behavioral outcomes. However, potential benefits of parent media use have also been identified, such as media use to cope with stress, stay connected, increase breastfeeding perseverance, and seek parenting information. Technoference has only been researched for about a decade, and there are large research gaps. We propose a research agenda to parse out long-term or cumulative …

Daily Smartphone Use Predicts Parent Depressive Symptoms, But Parents' Perceptions Of Responsiveness To Their Child Moderate This Effect., Brandon T. Mcdaniel Phd, Sabrina Uva, Jessica Pater, Victor P. Cornet Ms, Michelle Drouin Phd, Jenny Radesky

Health Services and Informatics Research

INTRODUCTION: Smartphone use during caregiving has become increasingly common, especially around infants and very young children, and this use around young children has been linked with lower quality and quantity of parent-child interaction, with potential implications for child behavior, and parent-child attachment. To understand drivers and consequences of parent phone use, we were interested in the daily associations between parent phone use and depressed mood, as well as the potential for parent perceptions of their responsiveness toward their infant to alter the association between parent phone use and mood.

METHODS: In the present study, we explored associations between day-to-day changes …

Heavy Users, Mobile Gamers, And Social Networkers: Patterns Of Objective Smartphone Use In Parents Of Infants And Associations With Parent Depression, Sleep, Parenting, And Problematic Phone Use., Brandon T. Mcdaniel Phd, Jenny Radesky, Jessica Pater, Adam M Galovan, Annalise Harrison, Victor P. Cornet Ms, Lauren Reining, Alexandria Schaller, Michelle Drouin

Health Services and Informatics Research

Smartphone use during parenting is common, which may lead to distraction (also known as technoference). However, it is likely that some phone activities are less disruptive to parents and children. In this study, we explored smartphone use (via passive sensing across 8 days) within 264 parents of infants, measuring parents' application use on their phone (e.g., messaging, social media, mobile gaming, video chat) and phone use across contexts (e.g., during feeding and at bedtime). We utilized latent profile analysis to identify profiles of users, revealing five user types:

Attachment Security And Problematic Media Use In Infancy: A Longitudinal Study In The United States., Jane Shawcroft, Sarah M Coyne, Lisa Linder, Brandon N Clifford, Brandon T. Mcdaniel Phd

Health Services and Informatics Research

Media use during childhood has quickly become a norm across the United States and in other countries. One area still not well understood is the development of problematic (or maladaptive and disruptive) media use in children. This research examines the role of attachment security as a central component in the development of problematic media use over time in a sample of 248 parent-child dyads (9.50% African American, 20.66% Hispanic, 62.81% White, 2.07% Asian, 4.96% other ethnicities). We examined the relationship between attachment security and problematic media use one and 2 years later. We then constructed a mediation model examining parent …

Image-To-Mesh Conversion Method For Multi-Tissue Medical Image Computing Simulations, Fotis Drakopoulos, Yixun Liu, Kevin Garner, Nikos Chrisochoides

Computer Science Faculty Publications

Converting a three-dimensional medical image into a 3D mesh that satisfies both the quality and fidelity constraints of predictive simulations and image-guided surgical procedures remains a critical problem. Presented is an image-to-mesh conversion method called CBC3D. It first discretizes a segmented image by generating an adaptive Body-Centered Cubic mesh of high-quality elements. Next, the tetrahedral mesh is converted into a mixed element mesh of tetrahedra, pentahedra, and hexahedra to decrease element count while maintaining quality. Finally, the mesh surfaces are deformed to their corresponding physical image boundaries, improving the mesh’s fidelity. The deformation scheme builds upon the ITK open-source library …

Enhancing Heart Disease Prediction With Reinforcement Learning And Data Augmentation, Gayathri R., Sangeetha S. K. B., Sandeep Kumar Mathivanan, Hariharan Rajadurai, Benjula Anbu Malar Mb, Saurav Mallik, Hong Qin

Computer Science Faculty Publications

The study presents a novel method to improve the prediction accuracy of cardiac disease by combining data augmentation techniques with reinforcement learning. The complex nature of cardiac data frequently presents challenges for traditional machine learning models, which results in subpar performance. In response, our fusion methodology improves predictive capabilities by augmenting data and utilizing reinforcement learning's skill at sequential decision-making. Our method predicts cardiac disease with an astounding 94 % accuracy rate, which is an outstanding result. This significant improvement outperforms existing techniques and shows a deeper comprehension of intricate data relationships. The amalgamation of reinforcement learning and data augmentation …

Enhanced Skin Cancer Diagnosis Through Grid Search Algorithm-Optimized Deep Learning Models For Skin Lesion Analysis, Rudresh Pillai, Neha Sharma, Sheifali Gupta, Deepali Gupta, Sapna Juneja, Saurav Malik, Hong Qin, Mohammed S. Alqahtani, Amel Ksibi

Computer Science Faculty Publications

Skin cancer is a widespread and perilous disease that necessitates prompt and precise detection for successful treatment. This research introduces a thorough method for identifying skin lesions by utilizing sophisticated deep learning (DL) techniques. The study utilizes three convolutional neural networks (CNNs)-CNN1, CNN2, and CNN3-each assigned to a distinct categorization job. Task 1 involves binary classification to determine whether skin lesions are present or absent. Task 2 involves distinguishing between benign and malignant lesions. Task 3 involves multiclass classification of skin lesion images to identify the precise type of skin lesion from a set of seven categories. The most optimal …

Flexible Fitting Of Alphafold2-Predicted Models To Cryo-Em Density Maps Using Elastic Network Models: A Methodological Affirmation, Maytha Alshammari, Jing He, Willy Wriggers

Computer Science Faculty Publications

Motivation: This study investigates the flexible refinement of AlphaFold2 models against corresponding cryo-electron microscopy (cryo-EM) maps using normal modes derived from elastic network models (ENMs) as basis functions for displacement. AlphaFold2 generally predicts highly accurate structures, but 18 of the 137 models of isolated chains exhibit a TM-score below 0.80. We achieved a significant improvement in four of these deviating structures and used them to systematically optimize the parameters of the ENM motion model.

Results: We successfully refined four AlphaFold2 models with notable discrepancies: lipid-preserved respiratory supercomplex (TM-score increased from 0.52 to 0.69), flagellar L-ring protein (TM-score increased from 0.53 …

Sccad: Cluster Decomposition-Based Anomaly Detection For Rare Cell Identification In Single-Cell Expression Data, Yunpei Xu, Shaokai Wang, Qilong Feng, Jiazhi Xia, Yaohang Li, Hong-Dong Li, Jianxin Wang

Computer Science Faculty Publications

Single-cell RNA sequencing (scRNA-seq) technologies have become essential tools for characterizing cellular landscapes within complex tissues. Large-scale single-cell transcriptomics holds great potential for identifying rare cell types critical to the pathogenesis of diseases and biological processes. Existing methods for identifying rare cell types often rely on one-time clustering using partial or global gene expression. However, these rare cell types may be overlooked during the clustering phase, posing challenges for their accurate identification. In this paper, we propose a Cluster decomposition-based Anomaly Detection method (scCAD), which iteratively decomposes clusters based on the most differential signals in each cluster to effectively separate …

Identifying Patterns For Neurological Disabilities By Integrating Discrete Wavelet Transform And Visualization, Soo Yeon Ji, Sampath Jayarathna, Anne M. Perrotti, Katrina Kardiasmenos, Dong Hyun Jeong

Computer Science Faculty Publications

Neurological disabilities cause diverse health and mental challenges, impacting quality of life and imposing financial burdens on both the individuals diagnosed with these conditions and their caregivers. Abnormal brain activity, stemming from malfunctions in the human nervous system, characterizes neurological disorders. Therefore, the early identification of these abnormalities is crucial for devising suitable treatments and interventions aimed at promoting and sustaining quality of life. Electroencephalogram (EEG), a non-invasive method for monitoring brain activity, is frequently employed to detect abnormal brain activity in neurological and mental disorders. This study introduces an approach that extends the understanding and identification of neurological disabilities …