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2024

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Articles 25501 - 25530 of 27159

Full-Text Articles in Medicine and Health Sciences

Ultrasound Guided Quadratus Lumborum Block Versus Transversus Abdominis Plane Block As Postoperative Analgesia In Patients Undergoing Abdominal Cancer Surgery, Ghada Fouad Amer, Nevert Adel Abdel Ghaffar Jan 2024

Ultrasound Guided Quadratus Lumborum Block Versus Transversus Abdominis Plane Block As Postoperative Analgesia In Patients Undergoing Abdominal Cancer Surgery, Ghada Fouad Amer, Nevert Adel Abdel Ghaffar

Mansoura Medical Journal

Background: Abdominal surgeries are often linked with post-operative pain (POP). The transverse abdominal plane (TAP) block is an efficient method for POP management in these patients. The quadratus lumborum (QL) block (QLB) is another method for the POP control. The current study aims to assess the efficiency and safety of QLB and TAP block for POP control after abdominal cancer surgeries. Methods: 98 cases scheduled for abdominal cancer surgery by using general anesthesia (GA) were comprised in this randomized study. They were randomly divided into 2 equal groups :(QL group) patient received GA plus bilateral QLB, (TAP group) patient received …


Assessment Of Response Of Enteropathic Spondyloarthritis To Different Types Of Biological Therapy; An Egyptian Single Center Study, Fatma Abozeid, Marwa Besar Jan 2024

Assessment Of Response Of Enteropathic Spondyloarthritis To Different Types Of Biological Therapy; An Egyptian Single Center Study, Fatma Abozeid, Marwa Besar

Mansoura Medical Journal

Introduction: Arthropathy is one of the most prevalent extraintestinal symptoms of inflammatory bowel disease (IBD). It may be either peripheral or axial spondyloarthropathy. Biological treatment as anti-tumor necrosis factor alpha (TNF𝛼) or anti-interleukin 12/23 (anti IL 12/23) have shown efficacy in controlling gut inflammation and reducing joint manifestation. Our aim of the study was to assess the different aspects of response (laboratory , endoscopically and radiologically) of axial arthropathy associated with IBD patients after receiving biological drugs including: anti TNF (infliximab and adalimumab)& anti IL 12/23 (ustekinumab)

Patients & methods:A single center observational study was conducted through one …


Urinary Vitamin D Binding Protein Level In Egyptian Systemic Lupus Erythematosus Patients: A Potential Biomarker For Lupus Nephritis And Its Association With Renal Activity, Elshahat A. Yousef, Eman Nagy, Omnia M. El Sayed Mohamed, Mohamed S. Elghonimy, Marwa Saleh Jan 2024

Urinary Vitamin D Binding Protein Level In Egyptian Systemic Lupus Erythematosus Patients: A Potential Biomarker For Lupus Nephritis And Its Association With Renal Activity, Elshahat A. Yousef, Eman Nagy, Omnia M. El Sayed Mohamed, Mohamed S. Elghonimy, Marwa Saleh

Mansoura Medical Journal

Background : Systemic Lupus Erythematosus (SLE) is an autoimmune inflammatory disease affecting various organs, notably the kidneys, leading to lupus Nephritis (LN) in approximately half of patients. Early and accurate diagnosis of lupus nephritis (LN) and initiation of therapy are crucial steps in halting disease progression. Despite its value as a gold standard for diagnosing, classifying, and guiding treatment for LN patients, renal biopsy is expensive, carries risks, and cannot expect the response to immunosuppressive therapy. Methods : The study included 80 SLE patients; 60 patients were biopsy-proven LN (30 patients with active LN, and 30 patients with LN in …


Coload Effect On Cardiac Output Measurement Using Transthoracic Echocardiography In Preeclamptic Patients Undergoing Cesarean Delivery, Sherine Ali Elsayed Bakrey, Aya Hasan Masoud Abdelhady, Alaa El-Din Mazy Abdou Mazy, Maha Ahmed Abo-Zeid Salim Jan 2024

Coload Effect On Cardiac Output Measurement Using Transthoracic Echocardiography In Preeclamptic Patients Undergoing Cesarean Delivery, Sherine Ali Elsayed Bakrey, Aya Hasan Masoud Abdelhady, Alaa El-Din Mazy Abdou Mazy, Maha Ahmed Abo-Zeid Salim

Mansoura Medical Journal

Background: During cesarean delivery (CD) for preeclamptic patients under spinal anaesthesia (SA), much intravenous fluids are avoided. Through transthoracic echocardiography, study conducted to assess the hypothesis that colloid plus crystalloid coload will maintain the cardiac output (CO) than crystalloid fluid alone. Methods: Thirty-four preeclamptic patients, scheduled for elective CD, under SA, were allocated according to the fluid coloading into two groups; Crystalloid group (group I); in which the patients received Ringer’s acetate or Crystalloid-colloid group (group II); in which the patients received 6% Hydroxyethyl starch and Ringer’s acetate. The primary outcome was CO while, left ventricular end diastolic diameter (LVEDD), …


Opioid-Free Anaesthesia During Prolonged Orthotopic Urinary Bladder Diversion Surgery: A Prospective Randomized Comparative Study, Mohamed A Ghanem, Mostafa Ma Saied, Hanan Adly, May E Badr Jan 2024

Opioid-Free Anaesthesia During Prolonged Orthotopic Urinary Bladder Diversion Surgery: A Prospective Randomized Comparative Study, Mohamed A Ghanem, Mostafa Ma Saied, Hanan Adly, May E Badr

Mansoura Medical Journal

Background: Opioid-free anaesthesia is becoming a favored strategy among anesthetists. This study aims to compare continuous epidural fentanyl infusion with intrathecal bolus of bupivacaine-dexmedetomidine, which is a low-cost analgesic technique with efficient intraoperative hemodynamic stability, postoperative analgesia, and fewer opioid induced drawbacks in urinary bladder diversion surgery.

Patient and Methods: Our randomized prospective comparative study involved 34 patients prepared for urinary bladder diversion surgery. Patients were distributed into two equivalent groups; group A received continuous epidural infusion of bupivacaine-fentanyl; and group B received intrathecal bolus bupivacaine-dexmedetomidine.

Results: Intraoperatively, Heart rate showed a significant decrease at 2 h in group B …


Ultrasound-Guided Femoro-Sciatic Nerve Block Versus Hemispinal Anesthesia In Acute Lower Limb Ischemia: A Prospective Randomized Comparative Study, Mostafa Sayed Ahmed Mohammed Elawady, Nehal Alaa El-Dien Abbass Hamza, Mohammed Ahmed Ahmed Sultan, Hazem Elsayed Moawad, Tarek Habeeb Ramadan Jan 2024

Ultrasound-Guided Femoro-Sciatic Nerve Block Versus Hemispinal Anesthesia In Acute Lower Limb Ischemia: A Prospective Randomized Comparative Study, Mostafa Sayed Ahmed Mohammed Elawady, Nehal Alaa El-Dien Abbass Hamza, Mohammed Ahmed Ahmed Sultan, Hazem Elsayed Moawad, Tarek Habeeb Ramadan

Mansoura Medical Journal

Background: Acute lower limb ischemia (ALLI) is a critical condition that requires prompt surgical intervention. The choice of anesthetic technique can have a significant impact on patient outcomes. The Purpose of this study was to compare the safety and efficacy of femoro-sciatic nerve block (FSNB) guided by ultrasound and hemispinal anesthesia (HSA) among patients undergoing surgery for acute lower limb ischemia.

Methods: We prospectively studied 44, ASA Ⅱ-Ⅲ patients whose surgeries were planned for management of acute lower limb ischemia. Eligible patients were randomly allocated into two groups to be given either HSA or ultrasound-guided FSNB. The duration of the …


Audit Of Management Of Diabetic Ketoacidosis In Mansoura Specialized Medical Hospital, Walaa M Abd-El-Fatah, Omnia I State, Basma Z Elmorsy Jan 2024

Audit Of Management Of Diabetic Ketoacidosis In Mansoura Specialized Medical Hospital, Walaa M Abd-El-Fatah, Omnia I State, Basma Z Elmorsy

Mansoura Medical Journal

Background: Egypt is listed among the world's top ten countries regarding the highest number of people with diabetes mellitus (DM). Diabetic ketoacidosis (DKA) is a medical emergency which is associated with significant mortality and morbidity in diabetic patients. It is also a common reason for hospitalization and thus is associated with significantly high costs. However, DKA is a potentially reversible condition provided that an emergency and immediate medical attention, appropriate diagnosis and therapy were provided.

Aim: auditing the adherence to protocol for the management of DKA in our Mansoura University Hospital (Specialized Medical Hospital) in Egypt from May 2021 to …


Evaluation Of Low Dose Intrathecal Bupivacaine With Dexmedetomidine In Geriatric Patients Undergoing Traumatic Hip Surgery, Rania E. Elbadrawy, Sherine A Bakrey, Reem Abdelraouf Elsharkawy Jan 2024

Evaluation Of Low Dose Intrathecal Bupivacaine With Dexmedetomidine In Geriatric Patients Undergoing Traumatic Hip Surgery, Rania E. Elbadrawy, Sherine A Bakrey, Reem Abdelraouf Elsharkawy

Mansoura Medical Journal

Abstract: Background: Spinal anesthesia (SA) is typically utilized during surgical treatment of severe hip fractures. Searching for early ambulation and reduction of frequency and severity of hypotension, and after adding dexmedetomidine (DEX), different intrathecal (IT) dosages of 0.5% hyperbaric bupivacaine had been used to determine the lowest dosage that will result in a good block without hemodynamic instability. Methods: At random, 78 patients were divided into three groups. A 7.5 mg of 0.5% hyperbaric bupivacaine was administered in the first group10 mg in the second and 12.5 mg in the third group. Dexmedetomidine (5 μg) was added to each group. …


Pathogenic Role Of Angiopoietin-1 And -2 In Community-Acquired Pneumonia Among A Cohort Of Egyptian Children From Rural Areas Of Delta Region, Magdy Mohamed Ebrahim Zedan, Nashwa Khairat Abousamra, Engy Osman Ahmed, Asmaa Salah Ali Gebril Jan 2024

Pathogenic Role Of Angiopoietin-1 And -2 In Community-Acquired Pneumonia Among A Cohort Of Egyptian Children From Rural Areas Of Delta Region, Magdy Mohamed Ebrahim Zedan, Nashwa Khairat Abousamra, Engy Osman Ahmed, Asmaa Salah Ali Gebril

Mansoura Medical Journal

Background: Both an uncontrolled host response and the direct actions of pathogenic agents can be responsible for pneumonia-induced pulmonary hyperpermeability. Two well-known factors that contribute to angiogenesis and regulate inflammation and vascular leakage are angiopoietin-1 (Ang 1) and angiopoietin-2 (Ang 2). Aim: Assessment of Ang 1 and Ang 2 serum levels as indicators of the severity and phenotypes of community-acquired pneumonia (CAP). Subjects and methods: From September 2023 to February 2024, a case-control study was carried out at Mansoura University Children Hospital (MUCH) to assess the serum levels of Ang-1 and Ang-2 as indicators of the severity and phenotypes of …


Is Hyponatremia A Predictor Of Severity And Mortality In Covid 19 Patients?, Manal Mohammed Reda Algharbawy, Mohamed Maher El-Gamal, Eman Ali Ahmed Ali Jan 2024

Is Hyponatremia A Predictor Of Severity And Mortality In Covid 19 Patients?, Manal Mohammed Reda Algharbawy, Mohamed Maher El-Gamal, Eman Ali Ahmed Ali

Mansoura Medical Journal

BACKGROUND: Hyponatremia is one of the commonest water–electrolyte imbalances in the body. It can occur in coincidence with many diseases and its presence can affect the disease outcome.

OBJECTIVE OF THE STUDY: to evaluate the relation between serum sodium level and both COVID disease severity and mortality.

METHODS: Study included 164 patients admitted to hospital with COVID-19. Serum sodium was measured on admission. 65 patients had serum sodium more than 135 mmol/l (either normal serum sodium or mild hypernatremia) while the remaining 99 had hyponatremia. Patients were treated and followed till discharge or death. Study included 3 categories of disease …


Guillain-Barré Syndrome In Adults And Children: Differences In Clinical Features, Mahmoud Moaness Elbialy, Maha H. Khalil, Khaled Fathy, Hossam Egila Jan 2024

Guillain-Barré Syndrome In Adults And Children: Differences In Clinical Features, Mahmoud Moaness Elbialy, Maha H. Khalil, Khaled Fathy, Hossam Egila

Mansoura Medical Journal

Background: Guillain-Barré Syndrome (GBS) is an autoimmune disease (AID) affecting peripheral nervous system (PNS) stimulated by either infectious (such as Campylobacter jejuni, Cytomegalovirus, Epstein-Barr virus, human immunodeficiency virus (HIV), Zika virus and SARS-CoV-2 infection) or noninfectious factors. It may occur at any age, and it is the commonest etiology of acute flaccid paralysis in pediatrics. Patients present with progressive and symmetric muscle weakness with absent or depressed deep tendon reflexes and might also have sensory manifestations such as Paresthesia in the hands and feet, dysautonomia and cranial nerve affection such as facial palsy or bulbar affection Aim: This study assessed …


The Investigation Of The Effects Of Adolescent Substance Use On Socioeconomic Outcomes During Adulthood, Bedis Elkamel Jan 2024

The Investigation Of The Effects Of Adolescent Substance Use On Socioeconomic Outcomes During Adulthood, Bedis Elkamel

Honors Undergraduate Theses

Background: Adolescence is a crucial point in life where choices, behaviors, and environmental influences can significantly shape future outcomes. This research investigates the increasing concerns surrounding adolescent substance use and examines its long-term effects on socioeconomic status (SES) in adulthood. Substance use during adolescence has been shown to have significant long-term physiological impacts, as the brain is still developing at this age. Additionally, many short- and long-term effects are associated with substance use, such as impacts on academics, physical and emotional well-being, and social life. Several studies have been conducted to explore the relationship between substance use and SES, however, …


Contributing Factors And Interventions For Increased Central Line-Associated Bloodstream Infection (Clabsi) Rates During The Covid-19 Pandemic: A Literature Review, Brittney Perry Jan 2024

Contributing Factors And Interventions For Increased Central Line-Associated Bloodstream Infection (Clabsi) Rates During The Covid-19 Pandemic: A Literature Review, Brittney Perry

Honors Undergraduate Theses

The purpose of this literature review is to determine the contributing factors of CLABSI rate increases during the COVID-19 pandemic and identify interventions which restored CLABSI rates to pre-pandemic levels to guide healthcare professionals’ actions during the next pandemic. Background: In the first two decades of the 21st century, CLABSI rates were reduced in United States hospitals by innovating safer patient care practices. However, there was a significant increase in the annual CLABSI rate in 2020 and 2021, increasing the average length of stay, mortality rate, and cost to the U.S. healthcare system. Methods: An extensive search of CINAHL …


Financial Issues And Trends Among Testicular Cancer Patients: A Review Of Patient-Reported Outcomes, Treatments, And Employment, Staphana Valery Edouard Jan 2024

Financial Issues And Trends Among Testicular Cancer Patients: A Review Of Patient-Reported Outcomes, Treatments, And Employment, Staphana Valery Edouard

Honors Undergraduate Theses

The present study reviewed existing literature on the effects of treatment and recovery costs on the multidimensional wellness of testicular cancer (TC) survivors. Peer-reviewed and scholarly articles were systematically searched and analyzed to determine the extent and impact of the overall financial effects of a TC diagnosis. This study aimed to uncover evidence indicating the possible decline in overall health-related quality of life (HRQoL) due to the potential deleterious effects on TC survivors’ financial well-being.

We found that TC survivors’ HRQoL is affected due to the damages of high out-of-pocket treatment costs, possible loss of employment, disability, and any other …


Recognizing Risk Factors Of Bronchopulmonary Dysplasia In Neonates ≥ 24 And ≤ 32 Weeks Of Gestational Age, Hannah Tatro Jan 2024

Recognizing Risk Factors Of Bronchopulmonary Dysplasia In Neonates ≥ 24 And ≤ 32 Weeks Of Gestational Age, Hannah Tatro

Honors Undergraduate Theses

Background: Bronchopulmonary dysplasia (BPD) is a chronic lung condition that is diagnosed among neonates who are on oxygen therapy for longer than 28 days. BPD causes insufficient gas exchange due to prematurely developed lungs and is the most common condition that causes morbidity of prematurity. Many risk factors contribute to the development of this condition and relate to care from the delivery room to the first few days of life.

Purpose: The purpose of this literature review is to examine risk factors related to the development of BPD in neonates from the gestational ages of 24 to 32 weeks.

Methods: …


Sars-Cov-2 Infection History Is Positively Correlated With Frequency Of Psychotic Symptoms In Schizophrenia, Jackson D. Beecher Jan 2024

Sars-Cov-2 Infection History Is Positively Correlated With Frequency Of Psychotic Symptoms In Schizophrenia, Jackson D. Beecher

Honors Undergraduate Theses

Previous work in human and animal studies has implicated aberrant insular cortex (IC) activity in the pathophysiology of hallucinations. Of note, the IC overlaps with the olfactory cortex (OC), a region of the brain that receives extensive projections from sensory neurons of the olfactory epithelium. SARS-CoV-2 (COVID-19) is a highly infectious coronavirus with a demonstrated ability to cause anosmia; the virus does this by colocalizing with and damaging support cells in the olfactory epithelium, ultimately leading to alterations in olfactory receptor cell signaling to the OC. Given the overlap between OC and IC, we asked the question of whether COVID-19 …


The Multigenerational Legacy Of Diabetes And Illness Perception: Influence On Older Adult’S Stigma, Melissa Scollan-Koliopoulos, Donna Naturale, Brynn Mahurter, Sara Curran, Ryan J. Koliopoulos Jan 2024

The Multigenerational Legacy Of Diabetes And Illness Perception: Influence On Older Adult’S Stigma, Melissa Scollan-Koliopoulos, Donna Naturale, Brynn Mahurter, Sara Curran, Ryan J. Koliopoulos

Nursing Faculty Publications

There is not enough information regarding the impact of stigma associated with a. diagnosis of diabetes in aging older adults. Perceptions of diabetes are passed down generationally and may be influenced by mainstream societal perceptions at the time the perception is shaped. This is known as a multigenerational legacy of diabetes for those with whom the perceptions are shaped within families when a hereditarily predisposed condition occurs. In this study, participants over the age of (n = 88) 60 years old were administered measures of illness perception with social stigma items added to the social consequences domain. Participants were also …


Knowledge Translation Task Force For Core Measures Clinical Practice Guideline: A Short Report On The Process And Utilization, Marghuretta D. Bland, Jennifer Moore, Elizabeth Anderl, Megan Eikenberry, Arlene Mccarthy, Geneviève N. Olivier, Tracy Rice, Amelia Siles, Hallie Zeleznik, Wendy Romney Jan 2024

Knowledge Translation Task Force For Core Measures Clinical Practice Guideline: A Short Report On The Process And Utilization, Marghuretta D. Bland, Jennifer Moore, Elizabeth Anderl, Megan Eikenberry, Arlene Mccarthy, Geneviève N. Olivier, Tracy Rice, Amelia Siles, Hallie Zeleznik, Wendy Romney

Physical Therapy Faculty Publications

Background

As part of the 2018 Clinical Practice Guideline (CPG): A Core Set of Outcome Measures for Adults with Neurologic Conditions Undergoing Rehabilitation, a Knowledge Translation (KT) Task Force was convened. The purpose of this short report was to (1) demonstrate the potential impact of a CPG KT Task Force through a practical example of efforts to implement a CPG into neurologic physical therapy practice and (2) describe the process to convene a KT Task Force and develop products (KT Toolkit) to facilitate implementation of the CPG.

Methods

To describe the process used by the KT Task Force to develop …


Feasibility And Safety Of Early Post-Covid-19 High-Intensity Gait Training: A Pilot Study, Joakim Halvorsen, Christopher Henderson, Wendy Romney, Magnus Hågå, Tonje Barkenæs Eggen, Jan Egil Nordvik, Ingvild Rosseland, Jennifer Moore Jan 2024

Feasibility And Safety Of Early Post-Covid-19 High-Intensity Gait Training: A Pilot Study, Joakim Halvorsen, Christopher Henderson, Wendy Romney, Magnus Hågå, Tonje Barkenæs Eggen, Jan Egil Nordvik, Ingvild Rosseland, Jennifer Moore

Physical Therapy Faculty Publications

Background: The feasibility and safety of rehabilitation interventions for individuals recovering from COVID-19 after the acute stage is not well understood. This pilot study aims to provide a preliminary investigation of the feasibility and safety of providing high-intensity gait training (HIT) with a targeted cardiovascular intensity of 70–85% of the age-predicted maximum heart rate (HRmax) for individuals undergoing rehabilitation post-COVID-19. Methods: Consecutive patients who were medically cleared for HIT were invited to participate in the study. Participants practiced walking in varied contexts (treadmill, overground, and stairs), aiming to spend as much time as possible within their target cardiovascular intensity zone …


Effect Of Covid-19 On Performance And Recovery Of Division I Women’S Basketball Players: A Case Study, Julie K. Nolan, Christopher Taber, Samah Senbel, Mehul S. Raval, N.S. Artan, Tolga Kaya Jan 2024

Effect Of Covid-19 On Performance And Recovery Of Division I Women’S Basketball Players: A Case Study, Julie K. Nolan, Christopher Taber, Samah Senbel, Mehul S. Raval, N.S. Artan, Tolga Kaya

Athletic Training Faculty Publications

This report aimed to examine the effects of COVID-19 on athletic performance and recovery in women’s basketball players. Twelve participants were included in this case report, with four serving as the test group and eight serving as the control group. All participants wore a Polar GPS unit and a Whoop Strap. The Polar unit was worn during games and practices and used to collect metrics of physical workload. The Whoop strap was worn during daily activities, including periods of sleep, to collect metrics of sleep and recovery. Data were analyzed via descriptive statistics (mean difference ± standard deviations), and T-tests …


Health Behaviors Predicting Risk Of Obesity In Us Adults: What Does A Healthy Lifestyle Look Like?, Jacqueline Vernarelli, Jessica R. Kiel, Christopher D. Coleman, Satya S. Jonnalagadda Jan 2024

Health Behaviors Predicting Risk Of Obesity In Us Adults: What Does A Healthy Lifestyle Look Like?, Jacqueline Vernarelli, Jessica R. Kiel, Christopher D. Coleman, Satya S. Jonnalagadda

Public Health Faculty Publications

Objective

The purpose of this study was to examine the association between lifestyle factors and body weight in a nationally representative sample of US adults and to evaluate the association between a novel “Healthy Habits Composite Score (HHCS)” and risk of obesity.

Methods

This cross-sectional study included data from 4870 adults who participated in the 2017–2018 National Health and Nutrition Examination Survey (NHANES). The HHCS was developed based on 4 factors: diet, physical activity, sedentary time, and sleep, all of which were measured during the NHANES. A “healthy lifestyle” was defined as meeting ≥3 of the 4 established criteria. Data …


Ceacam7 Expression Contributes To Early Events Of Pancreatic Cancer, Anupam Dhasmana, Swati Dhasmana, Sudhir Kotnala, Partha Laskar, Sheema Khan, Shafiul Haque, Meena Jaggi, Murali M. Yallapu, Subhash C. Chauhan Jan 2024

Ceacam7 Expression Contributes To Early Events Of Pancreatic Cancer, Anupam Dhasmana, Swati Dhasmana, Sudhir Kotnala, Partha Laskar, Sheema Khan, Shafiul Haque, Meena Jaggi, Murali M. Yallapu, Subhash C. Chauhan

School of Medicine Publications

Highlights

  • The trends of pancreatic cancer (PanCa) incidence and mortality are on rising pattern, and it will a second leading cause of cancer related deaths by 2030.
  • Approximately 85–90% PanCa are pancreatic ductal adenocarcinoma (PDAC), which is one of the most challenging and aggressive malignancy.
  • PDAC exhibits with grim prognosis as mortality rate is very close to the incidence due lack of early detection methods and effective therapeutic regimen.
  • Our team has identified a novel oncogenic protein, carcinoembryonic antigen-related cell adhesion molecule 7 (CEACAM7), that can be useful for early PDAC diagnosis and predictor of patient survival.
  • We also observed …


Focal Adhesion Is Associated With Lithium Response In Bipolar Disorder: Evidence From A Network-Based Multi-Omics Analysis, Vipavee Niemsiri, Sara Brin Rosenthal, Caroline M. Nievergelt, Adam X. Maihofer, Maria C. Marchetto, Renata Santos, Tatyana Shekhtman, Ney Alliey-Rodriguez, Amit Anand, Yokesh Balaraman Jan 2024

Focal Adhesion Is Associated With Lithium Response In Bipolar Disorder: Evidence From A Network-Based Multi-Omics Analysis, Vipavee Niemsiri, Sara Brin Rosenthal, Caroline M. Nievergelt, Adam X. Maihofer, Maria C. Marchetto, Renata Santos, Tatyana Shekhtman, Ney Alliey-Rodriguez, Amit Anand, Yokesh Balaraman

School of Medicine Publications

Lithium (Li) is one of the most effective drugs for treating bipolar disorder (BD), however, there is presently no way to predict response to guide treatment. The aim of this study is to identify functional genes and pathways that distinguish BD Li responders (LR) from BD Li non-responders (NR). An initial Pharmacogenomics of Bipolar Disorder study (PGBD) GWAS of lithium response did not provide any significant results. As a result, we then employed network-based integrative analysis of transcriptomic and genomic data. In transcriptomic study of iPSC-derived neurons, 41 significantly differentially expressed (DE) genes were identified in LR vs NR regardless …


Multicentric Assessment Of A Multimorbidity-Adjusted Disability Score To Stratify Depression-Related Risks Using Temporal Disease Maps: Instrument Validation Study, Rubèn González-Colom, Kangkana Mitra, Emili Vela, Andras Gezsi, Teemu Paajanen, Zsófia Gál, Gabor Hullam, Hannu Mäkinen, Tamas Nagy, Mikko Kuokkanen Jan 2024

Multicentric Assessment Of A Multimorbidity-Adjusted Disability Score To Stratify Depression-Related Risks Using Temporal Disease Maps: Instrument Validation Study, Rubèn González-Colom, Kangkana Mitra, Emili Vela, Andras Gezsi, Teemu Paajanen, Zsófia Gál, Gabor Hullam, Hannu Mäkinen, Tamas Nagy, Mikko Kuokkanen

School of Medicine Publications

Background: Comprehensive management of multimorbidity can significantly benefit from advanced health risk assessment tools that facilitate value-based interventions, allowing for the assessment and prediction of disease progression. Our study proposes a novel methodology, the Multimorbidity-Adjusted Disability Score (MADS), which integrates disease trajectory methodologies with advanced techniques for assessing interdependencies among concurrent diseases. This approach is designed to better assess the clinical burden of clusters of interrelated diseases and enhance our ability to anticipate disease progression, thereby potentially informing targeted preventive care interventions.

Objective: This study aims to evaluate the effectiveness of the MADS in stratifying patients into clinically relevant risk …


Predictive Modeling Of Healthcare Traffic Using Machine Learning: A Comparative Study, Shadman Mahmood Khan Pathan, Sakan Binte Imran, M. M. Shabab Iqbal, Muhammad Enayetur Rahman, Md Nurul Absar Siddiky, Muhammad Rezaur Rahman, Md. Rafid Hassan, Nondon Lal Dey, Md. Sobuj Hossain Jan 2024

Predictive Modeling Of Healthcare Traffic Using Machine Learning: A Comparative Study, Shadman Mahmood Khan Pathan, Sakan Binte Imran, M. M. Shabab Iqbal, Muhammad Enayetur Rahman, Md Nurul Absar Siddiky, Muhammad Rezaur Rahman, Md. Rafid Hassan, Nondon Lal Dey, Md. Sobuj Hossain

Electrical & Computer Engineering Faculty Publications

Effective healthcare traffic management is critical for ensuring prompt medical services, particularly in emergencies where delays can have life-threatening consequences. This study conducts a comparative analysis of three popular machine learning models—Linear Regression, Decision Trees, and Random Forests—for predicting healthcare-related traffic volumes. Utilizing a comprehensive dataset from a metropolitan interstate traffic system, the models were evaluated based on key performance metrics, including Mean Squared Error (MSE), R² Score, and execution time. The findings demonstrate that the Random Forest model outperforms the others, offering superior predictive accuracy and efficiency. These insights are valuable for optimizing traffic management in healthcare, ultimately contributing …


Successful Management Of Spontaneous Unilateral Twin Ectopic Pregnancy With Two-Step Dose Of Methotrexate, Lauren A. Forbes, Navya Nuthivana, Renee Morales Jan 2024

Successful Management Of Spontaneous Unilateral Twin Ectopic Pregnancy With Two-Step Dose Of Methotrexate, Lauren A. Forbes, Navya Nuthivana, Renee Morales

Department of Obstetrics & Gynecology Faculty Publications

The incidence of unilateral tubal twin pregnancy is 1/20,000–1/250,000 with about 100 reported cases. Four of the six cases that were medically managed were successful. A 24-year-old female presented to the emergency department (ED) with vaginal bleeding and abdominal cramping. She was hemodynamically stable without signs of an acute abdomen. Laboratory evaluation revealed she was pregnant with a serum beta-human chorionic gonadotropin (b-hCG) of 798 mIU/mL. Transvaginal ultrasound (TVUS) revealed a single left tubal pregnancy with a yolk sac. The patient elected medical management with body surface area (BSA)–based intramuscular (IM) methotrexate (MTX). On Day 4, the patient returned to …


Comparative Study Of Dynamic Cyclic Fatigue Resistance Of Two Files With Different Kinematics, Rahma Abdelshafy, Abeer Mahran, Mahmoud Fahim Jan 2024

Comparative Study Of Dynamic Cyclic Fatigue Resistance Of Two Files With Different Kinematics, Rahma Abdelshafy, Abeer Mahran, Mahmoud Fahim

International Arab Journal of Dentistry

Objectives: The aim of the study was to determine the dynamic cyclic fatigue resistance (DCFR) of R-motion file and Protaper Next file (PTN) by differential scanning calorimetry (DSC) and scanning electron microscopy (SEM).

Methods: R-motion file (25/.06), PTN file (25/.06) were used and divided into 2 groups (n = 28) according to the file type. DCFR was performed using an artificial canal. Files were allowed to work until separation. The numbers of cycles to failure (NCF) and the time to fracture (TTF) were calculated. The files were subjected to DSC and SEM.

Results: R-motion files had higher …


Clinical Assessment Of The Abutment Teeth Of Children Undergoing Space Maintainer Therapy: A Randomised Controlled Trial, Ayesha Fathima, Ganesh Jeevanandan, Prabhadevi Maganur, Suman Panda, Ather Syed Ahmed, Satish Vishwanathaiah Jan 2024

Clinical Assessment Of The Abutment Teeth Of Children Undergoing Space Maintainer Therapy: A Randomised Controlled Trial, Ayesha Fathima, Ganesh Jeevanandan, Prabhadevi Maganur, Suman Panda, Ather Syed Ahmed, Satish Vishwanathaiah

International Arab Journal of Dentistry

Introduction: The band and loop space maintainer are one of the most commonly used fixed space maintainers in children. However, prolonged use of appliances in the oral cavity may lead to changes in gingival health and an increased risk of caries.

Objectives: This study aims to evaluate the clinical parameters of the abutment teeth, specifically the banded teeth and the tooth to which the loop is extended.

Methods: This prospective clinical study included 35 children between the age group of 5 to 9 years. The children were examined at baseline and 6-month follow-up. The abutment teeth were …


Clinical Management Of Mandibular Permanent Premolars With Periapical Lesion And Bilateral Supernumerary Teeth: A 7-Year Follow-Up Case Report, Chiara Pirani, Shehabeldin Saber, Francesco Iacono Jan 2024

Clinical Management Of Mandibular Permanent Premolars With Periapical Lesion And Bilateral Supernumerary Teeth: A 7-Year Follow-Up Case Report, Chiara Pirani, Shehabeldin Saber, Francesco Iacono

International Arab Journal of Dentistry

Objectives: This 7-years follow-up case report describes two diversified strategies for the management of bilateral mandibular permanent premolars associated with periapical lesion and unerupted supernumerary teeth.

Case Report: A non-syndromic 9 years-old Asian female patient presented pain and swelling of the 35 in anatomical contiguity with an immature and unerupted supernumerary tooth. Clinical examination revealed an intraoral vestibular sinus tract related to the necrotic 35. Periapical radiography and CBCT showed that the 35 had an immature apex associated with a periapical lesion, and a supernumerary tooth in a lingual direction. Endodontic treatment of the 35 was performed by creating …


Assessment Of Clinical Performance Of Universal Adhesives Versus Other Adhesive Systems: A Systematic Review And Meta-Analysis Of Clinical Trials, Rim Bourgi, Naji Kharouf, Carlos Enrique Cuevas-Suárez, Cynthia Kassis, Ana Josefina Monjaras-Avila, Mohammad Qaddomi, Sophie Abi Raad, Mohammed Al Hasani, Youssef Haikel, Louis Hardan Jan 2024

Assessment Of Clinical Performance Of Universal Adhesives Versus Other Adhesive Systems: A Systematic Review And Meta-Analysis Of Clinical Trials, Rim Bourgi, Naji Kharouf, Carlos Enrique Cuevas-Suárez, Cynthia Kassis, Ana Josefina Monjaras-Avila, Mohammad Qaddomi, Sophie Abi Raad, Mohammed Al Hasani, Youssef Haikel, Louis Hardan

International Arab Journal of Dentistry

Universal adhesives (UAs) often exhibit comparable or even superior bond strength to traditional adhesive systems, ensuring reliable and long-lasting adhesion between the resin composite and the tooth structure. Therefore, this study aimed to assess the clinical performance of UAs compared to other adhesive systems in direct resin composite restorations through a systematic review and meta-analysis. Two reviewers executed a literature search in five electronic databases: PubMed, EMBASE, Scopus, Web of Science, and Scielo. Clinical trials comparing the clinical evaluation of resin composite restorations in Class I, Class II, or Class V cavities placed with an universal adhesive (UA) system against …