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2024

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Full-Text Articles in Medicine and Health Sciences

Intervention To Reduce Tobacco Use Among Prostate Cancer Patient And Informal Caregiver Dyads, Trupti Dhumal Jan 2024

Intervention To Reduce Tobacco Use Among Prostate Cancer Patient And Informal Caregiver Dyads, Trupti Dhumal

Graduate Theses, Dissertations, and Problem Reports (ETD)

Prostate cancer is the leading cancer in men. Continued tobacco use after prostate cancer diagnosis may affect a patient’s treatment outcomes, quality of life, and mortality. Despite the potential negative outcomes, 10-20% of prostate cancer patients continue to use tobacco after their cancer diagnosis. Considering risks associated with continued tobacco use, there is a lack of evidence-based tobacco cessation strategies to address tobacco cessation specifically in prostate cancer. Given the increasing prevalence of prostate cancer, the ongoing difficulty in tobacco cessation, and the limited evidence-based tobacco cessation interventions in the literature, it is important to prioritize reducing tobacco use in …


The Impact Of Normal Growth On The Ap Relationships Of The Jaws And Incisors To The Forehead: A Serial Cephalometric Analysis Of Untreated Individuals, Adam Joseph Rudmann Dr Jan 2024

The Impact Of Normal Growth On The Ap Relationships Of The Jaws And Incisors To The Forehead: A Serial Cephalometric Analysis Of Untreated Individuals, Adam Joseph Rudmann Dr

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

The Impact of Normal Growth on the AP Relationships of the Jaws and Incisors to the Forehead: A Serial Cephalometric Analysis of Untreated Individuals

Adam Rudmann D.D.S. M.S.

Background and Objectives

Growth of the craniofacial complex is a critical factor to consider when treatment planning an orthodontic case. The ability to predict how the forehead and jaws will change over time depends on the ability to find predictable landmarks either radiographically or clinically, and use them to gauge the relative growth of various facial structures. This data can then be integrated with other diagnostic information such as occlusion and …


Comparative Cephalometric Study Between Class Ii Patients Treated With Herbst Appliance And Patients Treated With Mara, Mona Meky Jan 2024

Comparative Cephalometric Study Between Class Ii Patients Treated With Herbst Appliance And Patients Treated With Mara, Mona Meky

Graduate Theses, Dissertations, and Problem Reports (ETD)

ABSTRACT

Comparative cephalometric study between Class II patients treated with Herbst appliance and patients treated with MARA

Mona Meky, D.D.S.

Background and Objectives: Functional appliances have been used for over 100 years in orthodontics to correct Class II malocclusions. The Herbst and the MARA appliances have different designs that may enhance mandibular growth. Recent clinical evidence has questioned whether they really have a lasting influence on facial growth and that the effects of these appliances were mostly dentoalveolar rather than skeletal. The objective of this retrospective comparative study was to compare the dental and skeletal changes between Class II division …


Dance Intervention For Stroke Rehabilitation: Restoring Occupational Performance Through Creative Movement, Olivia Paige Allen Jan 2024

Dance Intervention For Stroke Rehabilitation: Restoring Occupational Performance Through Creative Movement, Olivia Paige Allen

Graduate Theses, Dissertations, and Problem Reports (ETD)

Thousands of individuals are affected by cerebral vascular accidents, (CVA), also known as strokes in the United States each year, (CDC, 2023). Cerebral vascular accidents are one of the leading causes of death among the elderly population in the U.S. each year, (NIH et al., 2023). The deficits caused by a CVA can be global, from hemiparetic limbs and sensory loss to psychosocial impacts on an individual and their support system. In occupational therapy, the goal is to regain as much function and independence as possible for the individual who has experienced a CVA. Although many evidence-based intervention tools are …


Occupational Therapy’S Role In Low Vision Throughout The Lifespan, Ka Ki Tse Jan 2024

Occupational Therapy’S Role In Low Vision Throughout The Lifespan, Ka Ki Tse

Graduate Theses, Dissertations, and Problem Reports (ETD)

Low vision and blindness significantly affect individuals' engagement in occupational performance. While West Virginia (WV) offers low vision rehabilitation programs to enhance occupational performance, several challenges remain unresolved. This doctoral capstone project aimed to collaborate with low vision professionals to deliver comprehensive low vision services and advocate for the integration of occupational therapy practitioners (OTPs) in the low vision field. A needs assessment and literature review were conducted to identify gaps and develop strategies for addressing the gaps. A qualitative study design was chosen to explore the perspectives of current low vision providers regarding the role of OTPs. The study …


Advancing Opportunities For The Autistic Community At West Virginia University, Drew D. Altizer Jan 2024

Advancing Opportunities For The Autistic Community At West Virginia University, Drew D. Altizer

Graduate Theses, Dissertations, and Problem Reports (ETD)

Students with Autism Spectrum Disorder often have difficulties with social integration and sensory challenges on collegiate campuses. These difficulties are sometimes tied together as social integration spaces are not always sensory-friendly and can be overwhelming for the individual. Creating a sensory-friendly space within the potentially overstimulating environment can provide the student with a place to recharge and recover and still access the desired social events. This capstone project focused on the design and development of a sensory room in the West Virginia University Mountain Lair Student Union, working directly with the students in the West Virginia University Autism Support Program …


An Inquiry Into The Accessibility Of Campus Recreation For College Students With Disabilities, Kayla B. Abrahamson Jan 2024

An Inquiry Into The Accessibility Of Campus Recreation For College Students With Disabilities, Kayla B. Abrahamson

Graduate Theses, Dissertations, and Problem Reports (ETD)

University recreation centers are identified as the main sources of physical activity for college students. However, an estimated 68% of college students with disabilities (SWD) use their campus recreational facilities less than five times per year (Yoh et al., 2008). Structural and programmatic accessibility barriers may account for low facility use and corresponding low physical activity levels among college SWD. An accessibility assessment of facilities and programming is warranted to identify priority areas for barrier removal. This collective case study evaluates the accessibility of three campus recreation facilities at 4-year public universities in the southeast U.S. Adopting a mixed-method approach, …


Teaching Cultural Humility Practices In Appalachia: The Value Of Conducting Conversations Based In Education, Bailey A. Riggs Jan 2024

Teaching Cultural Humility Practices In Appalachia: The Value Of Conducting Conversations Based In Education, Bailey A. Riggs

Graduate Theses, Dissertations, and Problem Reports (ETD)

Recent literature highlights the paradigm shift from utilizing cultural competence practices to cultural humility practices within the field of occupational therapy, and health sciences (Fisher- Borne, et al., 2015). The idea of cultural competency suggests that culture is unchanging, and individuals can master cultural knowledge. The perception of knowing culture can be perceived as an unwillingness to learn about culture. In contrast, cultural humility promotes the value of lifelong learning and introspection, encouraging greater self-awareness, reflection of personal biases, and recognition of power imbalances. This approach aims to better integrate educational approaches to serve diverse populations in a culturally affirming …


Development And Implementation Of Occupational Therapy Group Protocols For Individuals In Recovery For Substance Use Disorder: Considering Social Determinants Of Health And Occupational Areas Of Need, Samantha Jane Windisch Jan 2024

Development And Implementation Of Occupational Therapy Group Protocols For Individuals In Recovery For Substance Use Disorder: Considering Social Determinants Of Health And Occupational Areas Of Need, Samantha Jane Windisch

Graduate Theses, Dissertations, and Problem Reports (ETD)

Substance use disorders (SUDs) are becoming a more widespread issue globally. According to the National Survey on Drug Use and Health, 19.7 million adults in the U.S. suffered from an SUD in 2017. (SAMSHA, 2018). Recurrent alcohol and/or drug use that results in significant disability, including health issues, and/or a failure to prioritize obligations like employment, school, or family life are characteristics of SUD (SAMHSA, 2022). Research suggests that healthcare providers must integrate cutting-edge and successful treatments for this population to lower the risk of overdose and relapse rates, given the swift global spread of addictive disorders. In the past, …


Benefits And Barriers Of Using Prefilled Precedex Syringes In The Operating Room: A Cost Comparison, Ashley White Jan 2024

Benefits And Barriers Of Using Prefilled Precedex Syringes In The Operating Room: A Cost Comparison, Ashley White

Graduate Theses, Dissertations, and Problem Reports (ETD)

According to a report published by the Institute of Medicine, at least 44,000 and possibly up to 98,000 Americans die each year because of medical errors in hospitals. More than 7,000 of those deaths are from medication errors alone (Stucki et al., 2013). Anesthesia providers in the operating room (OR) are at even greater risk to commit medication errors due to their easy access to medications and their autonomy to make independent choices for medication administration. A small rural community hospital in Pennsylvania lacks a protocol for Precedex preparation. Evidence-based research show the benefit of prefilled ready-to-administer syringes, but the …


Interactions Between Myeloid Cells And Neutrophil Extracellular Traps In Pancreatic Ductal Adenocarcinoma, Hillary Gabrielle Pratt Jan 2024

Interactions Between Myeloid Cells And Neutrophil Extracellular Traps In Pancreatic Ductal Adenocarcinoma, Hillary Gabrielle Pratt

Graduate Theses, Dissertations, and Problem Reports (ETD)

The 5-year-survival rate for pancreatic ductal adenocarcinoma (PDAC) is only 12% due in part to a lack of therapeutic strategies that target the pathophysiology of the disease. The only known curative therapy is surgical resection of the PDAC tumor, but only 20% of patients are eligible at the time of presentation. To improve outcomes for patients, new therapeutic options are needed. The PDAC tumor microenvironment (TME) is uniquely fibrotic and hypoxic, which is in part driven by the immune cell composition in the TME. Myeloid cells are a prominent immune infiltrate within the PDAC TME, so these cells have been …


Clinical Significance Of Gutta Percha Variability, Alex R. Pancake Jan 2024

Clinical Significance Of Gutta Percha Variability, Alex R. Pancake

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction: The production of gutta percha points as root canal therapy filling materials vary from hand processing to machine processing with a range of acceptable levels of error (tolerance). Similarly, endodontic files manufactured to complement corresponding gutta percha points exhibit specified levels of tolerance. Investigations into the consistency among manufacturers of files and gutta percha points is limited. The aim of this study is to see how variability in apical gauge and taper of gutta percha points affected the clinical performance during cone try in. The null hypothesis of this study is that there is no difference in two gutta …


A Structured Diabetes Continuous Glucose Monitor Education Program To Improve Patient Knowledge And Self-Efficacy, Krystal Abucevicz-Swick Jan 2024

A Structured Diabetes Continuous Glucose Monitor Education Program To Improve Patient Knowledge And Self-Efficacy, Krystal Abucevicz-Swick

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction/background: Continuous glucose monitor (CGM) is a recommended method of glucose monitoring for patients living with diabetes who are on insulin or experience documented hypoglycemia. CGM is a tool that can improve patient management of diabetes but works best when paired with education to achieve the maximum therapeutic benefits.

Purpose: The purpose of this project was (1) to develop an evidence-based structured CGM education program toolkit for people with diabetes who are ordered CGM, (2) to implement the CGM education toolkit into the Diabetes Self-Management and Education Services (DSMES) program at the project site, (3) to improve patient knowledge about …


Examination Of The Time Course Effects Of Electronic Cigarettes On The Thoracic Aorta, Madison Robinson Jan 2024

Examination Of The Time Course Effects Of Electronic Cigarettes On The Thoracic Aorta, Madison Robinson

Graduate Theses, Dissertations, and Problem Reports (ETD)

Endothelial dysfunction is a critical early marker of the pathogenesis of cardiovascular disease and a pathological biomarker in cigarette smokers. Emerging evidence finds similar cardiovascular risks resulting from electronic cigarettes (E-cig) as that seen from smoking. Logically, the time or length of exposure to E-cigs will likely influence the development of vascular dysfunction, however, the length of exposure that causes permanent damage is unknown. The goal of this study was to determine the potential window of chronic E-cig exposure that results in vascular dysfunction, which is marked by endothelial dysfunction, microvascular dysfunction, and stiffening of arteries. Based on prior chronic …


Characterizing 4,4’-Methylene Diphenyl Diisocyanate Exposure In Primary Human Epidermal Keratinocytes: A Multi-Omics Approach, Brandon F. Law Jan 2024

Characterizing 4,4’-Methylene Diphenyl Diisocyanate Exposure In Primary Human Epidermal Keratinocytes: A Multi-Omics Approach, Brandon F. Law

Graduate Theses, Dissertations, and Problem Reports (ETD)

Exploring the routes of exposure and biological fate of 4,4’-methylene diphenyl diisocyanate (MDI) has been a challenge for many years. Occupational exposure to MDI can result in the development of occupational asthma (MDI-OA) which results in loss of productivity, large economic costs, and costs to the individual worker. Initially, it was thought that respiratory exposure to MDI was the most likely route leading to MDI-OA. Industries utilizing MDI have been successful at controlling airborne concentrations according to industrial hygiene assessment and newly diagnosed cases of MDI-OA decreased and plateaued. New research suggests that dermal exposures to MDI may explain this …


Multidisciplinary Approach To Injury Rehabilitation: The D1 College Athlete Perspective, Lindsey Leatherman Jan 2024

Multidisciplinary Approach To Injury Rehabilitation: The D1 College Athlete Perspective, Lindsey Leatherman

Graduate Theses, Dissertations, and Problem Reports (ETD)

Sport injuries continue to be unavoidable disruptions in student-athletes’ athletic careers with over 200,000 injuries estimated to be reported each year in college sport (Kerr et al., 2015). Researchers continue to emphasize the importance of an interprofessional approach to rehabilitation to help athletes manage the adverse psychological and emotional reactions to injury (Appaneal et al., 2009; Gervis et al., 2020; Putukian, 2016). The purpose of this study was to extend and replicate the research of Clement and Arvinen-Barrow (2021) by incorporating perspectives of Division I US student-athletes. The current study describes 321 NCAA Division I collegiate athletes’ experiences of receiving …


Demonstrating The Need For Intergenerational Trauma-Specific Substance Use Treatment For Mothers Receiving Substance Use Treatment And Their Children, Brittany Ti-Esha Smith Jan 2024

Demonstrating The Need For Intergenerational Trauma-Specific Substance Use Treatment For Mothers Receiving Substance Use Treatment And Their Children, Brittany Ti-Esha Smith

Graduate Theses, Dissertations, and Problem Reports (ETD)

For decades the United States has faced substance use epidemics that have devastating public health consequences, with the most recent epidemic being the opioid epidemic. While the substance that is the center of the epidemic’s changes over time, one factor that has been found to be positively related to substance use has remained consistent, that preventable risk factor is adverse childhood experiences (ACEs). Those who experience ACEs are at elevated risk for developing SUD. If the trauma that is a result of experiencing ACE is not treated it can complicate recovery and impact the individuals’ families. The children of individuals …


The Impact Of Scaling And Root Planning Combined With Mouthwash During Pregnancy On Preterm Birth And Low Birth Weight: A Systematic Review And Meta-Analysis, May Salama, Abdullah Al-Taiar, Denise C. Mckinney, Estiar Rahman, Anwar T. Merchant Jan 2024

The Impact Of Scaling And Root Planning Combined With Mouthwash During Pregnancy On Preterm Birth And Low Birth Weight: A Systematic Review And Meta-Analysis, May Salama, Abdullah Al-Taiar, Denise C. Mckinney, Estiar Rahman, Anwar T. Merchant

Dental Hygiene Faculty Publications

The effect of treating periodontal disease (PD) during pregnancy on adverse birth outcomes, such as preterm birth (PTB) and/or low birth weight (LBW), remains unclear. This is partially due to the fact that Randomized Controlled Trials (RCTs) have used different combinations of treatment approaches to test this hypothesis. In this meta-analysis of RCTs, we assessed the impact of treating PD during pregnancy with scaling and root planning (SRP) and mouthwash use on PTB and LBW.

Background

The effect of treating periodontal disease (PD) during pregnancy on adverse birth outcomes, such as preterm birth (PTB) and/or low birth weight (LBW), remains …


The Importance Of Family Oral Health Education In Promoting Children's Oral Health, Denise C. Mckinney, Melissa Sullivan Jan 2024

The Importance Of Family Oral Health Education In Promoting Children's Oral Health, Denise C. Mckinney, Melissa Sullivan

Dental Hygiene Faculty Publications

No abstract provided.


Allied Dental Students' Perceived Knowledge, Confidence, And Attitudes Regarding Disaster Victim Identification Topics, Samantha C. Vest, Brenda T. Bradshaw, Marsha A. Voelker, Ann M. Bruhn, Tara L. Newcomb, Sinjini Sikdar Jan 2024

Allied Dental Students' Perceived Knowledge, Confidence, And Attitudes Regarding Disaster Victim Identification Topics, Samantha C. Vest, Brenda T. Bradshaw, Marsha A. Voelker, Ann M. Bruhn, Tara L. Newcomb, Sinjini Sikdar

Dental Hygiene Faculty Publications

Purpose Disaster victim identification (DVI) service requires knowledge, confidence, and an attitude (KCA) of readiness. The purpose of this study was to assess allied dental students’ perceived KCA regarding DVI skills and topics.

Methods A convenience sample of senior dental hygiene students (n=27) and senior dental assistant students (n=14) were recruited by email then presented mismatched simulated antemortem (AM) and postmortem (PM) bitewing radiographs and asked to indicate correct matches. Collectively, participants made 205 radiographic matches and indicated 205 degrees of certainty binarily as “positive” or “possible” (one per match). Participants also completed a researcher designed pretest/posttest electronic survey with …


Student Productivity Log: An Innovative Approach To Managing Clinic Sessions With No Patient, Tara L. Newcomb, Jessica Suedbeck, Lauren Eusner, Amber W. Hunt Jan 2024

Student Productivity Log: An Innovative Approach To Managing Clinic Sessions With No Patient, Tara L. Newcomb, Jessica Suedbeck, Lauren Eusner, Amber W. Hunt

Dental Hygiene Faculty Publications

No abstract provided.


Effects Of Ultrasonic Use On Hearing Loss In Dental Hygienists: A Matched Pairs Design Study, Jessica Suedbeck, Emily A. Ludwig, James Blando, Nathan Michalak Jan 2024

Effects Of Ultrasonic Use On Hearing Loss In Dental Hygienists: A Matched Pairs Design Study, Jessica Suedbeck, Emily A. Ludwig, James Blando, Nathan Michalak

Dental Hygiene Faculty Publications

Purpose: Dental professionals are exposed to hazardous noise levels on a daily basis in clinical practice. The purpose of this study was to compare the hearing status of dental hygienists who utilize ultrasonic scalers in the workplace compared to age-matched control participants (non-dental hygienists) who were not exposed to ultrasonic noise.

Methods: A convenience sample of nineteen dental hygienists (experimental) and nineteen non-dental hygienists (control) was recruited for this study. A matched pairs design was utilized; participants in each group were matched based on age and gender to eliminate confounding variables. The testing procedure consisted of an audiologist performing a …


Prevalence Of Sexually Implicit Attitudes In Entry-Level Dental Hygiene Students, Monica Drew, Emily Ludwig, Jessica Suedbeck, Adaira Howell Jan 2024

Prevalence Of Sexually Implicit Attitudes In Entry-Level Dental Hygiene Students, Monica Drew, Emily Ludwig, Jessica Suedbeck, Adaira Howell

Dental Hygiene Faculty Publications

Purpose: There has been an increase in the number of persons identifying as LGBTQ+ in the United States. LQBTQ+ individuals are also subject to social stigmas and discrimination which create barriers to obtaining quality healthcare. Providers may harbor implicit or unconscious biases which may negatively affect their ability to provide impartial health or oral healthcare. An awareness of biases early in education may promote equitable care and increase quality of oral healthcare delivered to diverse populations. The purpose of this study was to determine prevalence of sexually implicit attitudes in entry-level dental hygiene students in one university.

Methods: This cross-sectional …


Dietitian & Physician Preferences Of Fiber Use In Enteral Nutrition: A Pilot Study, Holly Gauthun, Thy Pham, Cory Gheen, Liang Ji, Edward Bitok, Susie Ray Jan 2024

Dietitian & Physician Preferences Of Fiber Use In Enteral Nutrition: A Pilot Study, Holly Gauthun, Thy Pham, Cory Gheen, Liang Ji, Edward Bitok, Susie Ray

Loma Linda University Research Reports

This pilot study examines the beliefs and preferences regarding fiber use in enteral nutrition (EN) among physicians and registered dietitians (RDs) for hemodynamically stable critically ill patients. A total of 30 RDs and 12 physicians participated. The majority of both physicians (80%) and RDs (83%) supported fiber use in EN for these patients. All participants with over ten years of experience and all Certified Nutrition Support Clinicians (CNSCs) endorsed fiber use. Despite expectations, no significant difference in support was found between RDs and physicians. The study reveals a noteworthy shift towards endorsing fiber use in enteral nutrition for hemodynamically stable …


Association Between Early Childhood Feeding Practices And Parental Perception Of Picky Eating, Yue-Liang Brewerton, Anoud Mohammad, Linda Navarro, Cindy Kosch, Gurinder Bains, Liang Ji, Edward Bitok Jan 2024

Association Between Early Childhood Feeding Practices And Parental Perception Of Picky Eating, Yue-Liang Brewerton, Anoud Mohammad, Linda Navarro, Cindy Kosch, Gurinder Bains, Liang Ji, Edward Bitok

Loma Linda University Research Reports

Introduction: This study aimed to investigate the association between early childhood feeding practices and picky eating behaviors in children aged 5-10 years.

Methods: Forty-three parents or legal guardians of children aged 5-10 completed the Child Feeding Questionnaires (CFQ) and the Children’s Eating Behavior Questionnaire (CEBQ) to assess parental control in child feeding and child eating behaviors, respectively. Logistic regression was used to analyze the relationship between the exposure and outcome variables.

Results: Infants fed store-bought food didn't differ significantly in picky eating from those fed self-made food, challenging conventional assumptions. Additionally, while socioeconomic status and parental education didn't show significant …


Effects Of Intuitive Eating Principles And Magnesium Glycinate On Quality Of Life, Body Satisfaction, And Stress In Early- And Middle-Aged Adults, Numydia Cotry, Taylor Kalinowski, Angel Wilensky Jan 2024

Effects Of Intuitive Eating Principles And Magnesium Glycinate On Quality Of Life, Body Satisfaction, And Stress In Early- And Middle-Aged Adults, Numydia Cotry, Taylor Kalinowski, Angel Wilensky

Loma Linda University Research Reports

This study investigated the impact of combining Intuitive Eating (IE) principles with magnesium glycinate supplementation on adults aged 18 to 49. Participants were split into two groups: one practicing IE alone and another receiving magnesium supplementation alongside IE. Results showed significant improvements in body satisfaction, stress levels, and overall health among those receiving magnesium. Qualitative data indicated enhanced body awareness and well-being with IE. This suggests a promising synergy between IE and magnesium supplementation for better health and quality of life. However, further research with larger samples and longer durations is warranted.


The Effects Of Hydration Status On Grip Strength, Loradelle Feri, Jordan Sales, Angela Li, Devon Cannata, Cindy L. Kosch, Gurinder Bains, Liang Ji, Everett B. Lohman, Lee Berk, Edward K. Bitok Jan 2024

The Effects Of Hydration Status On Grip Strength, Loradelle Feri, Jordan Sales, Angela Li, Devon Cannata, Cindy L. Kosch, Gurinder Bains, Liang Ji, Everett B. Lohman, Lee Berk, Edward K. Bitok

Loma Linda University Research Reports

Introduction: This study aimed to investigate the influence of hydration status on hand grip strength in a sample of the general population.

Methods: Fourteen participants (4 males and 10 females) aged 18 and older, were recruited from the Loma Linda University area. Participants underwent multiple clinic visits, where they were randomly assigned to either optimal or suboptimal hydration conditions. Measurements included hand grip strength using a dynamometer, extracellular water ratio via bioimpedance analysis, and urine specific gravity.

Results: There was no significant differences in hand grip strength, extracellular water ratio, or urine specific gravity between optimal and suboptimal hydration states. …


How Phonological And Syntactic Overlap Impact Cognate Processing Speeds In Bilinguals, Ella Marie Peterson Jan 2024

How Phonological And Syntactic Overlap Impact Cognate Processing Speeds In Bilinguals, Ella Marie Peterson

Undergraduate Theses, Professional Papers, and Capstone Artifacts

This paper investigates individuals who are proficient in two languages (bilinguals) and the speeds at which bilinguals process cognates (words with comparable form and meaning across languages). This paper cites two ongoing experiments: The Language Identification (LID) task and the Self-Paced Listening (SPL) task. Findings from the LID suggest that phonological overlap in cognates facilitates bilingual language processing speeds, when cognates are presented in isolation. Findings from the SPL suggest that syntactic overlap in cognates also facilitates bilingual language processing speeds, when cognates are presented in sentences. These findings are significant in that the tasks present cognates to participants in …


In Silico Identifcation Of New Potential Inhibitors Of Quorum Sensing By Gram‑Positive Bacteria Through Specialized Molecular Docking, Amgad Albohy, Najla A. Obaid, Mariam Mojally, Mohammed Abou Rehab, Najd Ahmad Alkhudhir Jan 2024

In Silico Identifcation Of New Potential Inhibitors Of Quorum Sensing By Gram‑Positive Bacteria Through Specialized Molecular Docking, Amgad Albohy, Najla A. Obaid, Mariam Mojally, Mohammed Abou Rehab, Najd Ahmad Alkhudhir

Pharmacy

Quorum sensing is the process by which bacterial cells can communicate by producing substances to regulate viable processes such as gene expression, virulence, and bioflm formation. Gram-positive bacteria such as Staphylococcus aureus and Enterococcus faecalis have specifc enzymes (autoinducers) that control the quorum sensing system. Sortase A is a surface protein that regulates virulence and cell‒cell communication in Gram-positive bacteria. To interfere with this system and reduce virulence and cell‒cell communication, quorum sensing inhibitors are used, which are nonantibiotic substances. In this study, we aimed to use Food and Drug Administration-approved drugs (analgesics and antipsychotics) and investigate their activity using …


Chemical Synthesis And Biological Application Of Sensitive Rna, Alexander T. Apostle Jan 2024

Chemical Synthesis And Biological Application Of Sensitive Rna, Alexander T. Apostle

Dissertations, Master's Theses and Master's Reports

In the field of epigenetics - the dynamic collection of chemical modifications that overlay DNA/RNA - there is increasing interest in the potential for therapeutic and research-based utilization of the epitranscriptomics: those epigenetic modifications specific to RNA. Epitranscriptomics can give us a new approach to understanding and treating RNA viruses, like SARS-CoV-2. Given viruses are often found modified by human epitranscriptomic machinery, understanding how these modifications can modulate virulence is of high interest. We have shown that the N1-methyladensoine modification causes RNA synthesis termination in the SARS-CoV-2 replication complex, and thus may explain the differences in symptoms observed in individuals. …