Medicine and Health Sciences Commons^™

A Structured Review Of The Associations Between Breast Cancer And Exposures To Selected Organic Solvents, Sydney Westra, Mark S. Goldberg, France Labrèche, Jill Baumgartner, Vikki Ho

Revues de littérature, synthèses de connaissances

Introduction

Our objective was to identify published, peer-reviewed, epidemiological studies that estimated associations between the risk of developing or dying from malignant breast cancer and past exposure to selected organic solvents with reactive metabolites, to delineate the methods used and to synthesize the results.

Content

We undertook a structured review of case-control and cohort studies used to investigate breast cancer risk and exposure to selected organic solvents that produce reactive metabolites in the body. We used SCOPUS, MEDLINE (Ovid) and Web of Science databases from 1966 to December 31, 2023 to identify epidemiological studies that estimated associations between the risk …

Post-Discharge Malaria Chemoprevention In Children Admitted With Severe Anaemia In Malaria-Endemic Settings In Africa: A Systematic Review And Individual Patient Data Meta-Analysis Of Randomised Controlled Trials, Kamija Phiri, Carole Khairallah, Titus Kwambai, Kalifa Bojang, Aggrey Dhabangi, Robert Opoka, Richard Idro, Kasia Stepniewska, Michael Boele Van Hensbroek, Chandy C John

Paediatrics and Child Health, East Africa

Background: Severe anaemia is associated with high in-hospital mortality among young children. In malaria-endemic areas, surviving children also have an increased risk of mortality or readmission after hospital discharge. We conducted a systematic review and individual patient data meta-analysis to determine the efficacy of monthly post-discharge malaria chemoprevention in children recovering from severe anaemia.

Methods: This analysis was conducted according to PRISMA-IPD guidelines. We searched multiple databases on Aug 28, 2023, without date or language restrictions, for randomised controlled trials comparing monthly post-discharge malaria chemoprevention with placebo or standard of care among children (agedyears) admitted with severe anaemia in malaria-endemic …

Association Of Maternal Prenatal Copper Concentration With Gestational Duration And Preterm Birth: A Multicountry Meta-Analysis Author Links Open Overlay Panel., Nagendra Monangi, Huan Xu, Yue-Mei Fan, Rasheeda Khanam, Waqasuddin Khan, Saikat Deb, Jesmin Pervin, Joan Price, Lovejeet Kaur, R. Ochieng

Paediatrics and Child Health, East Africa

Background: Copper (Cu), an essential trace mineral regulating multiple actions of inflammation and oxidative stress, has been implicated in risk for preterm birth (PTB).

Objectives: This study aimed to determine the association of maternal Cu concentration during pregnancy with PTB risk and gestational duration in a large multicohort study including diverse populations.

Methods: Maternal plasma or serum samples of 10,449 singleton live births were obtained from 18 geographically diverse study cohorts. Maternal Cu concentrations were determined using inductively coupled plasma mass spectrometry. The associations of maternal Cu with PTB and gestational duration were analyzed using …

Design, Synthesis, Molecular Docking, And Molecular Dynamic Studies Of Novel Quinazoline Derivatives As Phosphodiesterase 7 Inhibitors, Marwa M. Safar Prof. Dr.

Pharmacy

Introduction: Phosphodiesterase 7 (PDE7) is a high-affinity cyclic AMP (cAMP)- specific PDE that is expressed in immune and proinflammatory cells. In this work, we explore the possibility that selective small molecule inhibitors of this enzyme family could provide a novel approach to alleviate the inflammation that is associated with many inflammatory diseases. Methods: A series of novel substituted 4-hydrazinoquinazoline derivatives and fused triazoloquinazolines were designed, synthesized, and evaluated in vitro for their PDE7A inhibition activities, in comparison with Theophylline, a non-selective PDE inhibitor, and BRL50481, a selective PDE7A inhibitor. This series of novel quinazoline derivatives were synthesized via multi-step reactions. …

Investigating The Use Of Serious Games For Cancer Control Among Children And Adolescents: Scoping Review, Sunghak Kim, Ebling Library, Olufunmilola Abraham

Pharmacy Practice and Science Faculty Publications

Background: Effective health care services that meet the diverse needs of children and adolescents with cancer are required to alleviate their physical, psychological, and social challenges and improve their quality of life. Previous studies showed that serious games help promote people’s health. However, the potential for serious games to be used for successful cancer control for children and adolescents has received less attention.

Objective: This scoping review aimed to map the use of serious games in cancer prevention and cancer care for children and adolescents, and provide future directions for serious games’ development and implementation within the context of cancer …

Better Choices, Better Health South Dakota: The Association Between Perceived Loneliness And Self-Reported Health Measures Among Older Adults, Mckensey Bultje

Schultz-Werth Award Papers

The current study examined how Better Choices, Better Health South Dakota (BCBH-SD) programs impact older adults’ perceived loneliness, self-reported health measures, functional status, and confidence in managing their chronic condition. Sixty percent of U.S. adults report having a chronic condition (CDC, 2022), and adults with chronic conditions report higher levels of loneliness, increasing one’s health problems, maladaptive coping skills, and a diminished sense of self (Christiansen et al., 2021; Hammond and Pullen, 2020). We compared outcome measures between and within the two groups at pre- and post-survey timepoints. Pre-survey and post-survey loneliness measures revealed a significant difference between the groups, …

Biodegradable Nanoparticles Targeting Circulating Immune Cells Reduce Central And Peripheral Sensitization To Alleviate Neuropathic Pain Following Spinal Cord Injury., Michael N. Saunders, Kate V. Griffin, Irina Kalashnikova, Daniel Kolpek, Dominique R. Smith, Eiji Saito, Brian J. Cummings, Aileen J. Anderson, Lonnie D. Shea, Jonghyuck Park

Pharmaceutical Sciences Faculty Publications

Neuropathic pain is a critical source of comorbidity following spinal cord injury (SCI) that can be exacerbated by immune-mediated pathologies in the central and peripheral nervous systems. In this article, we investigate whether drug-free, biodegradable, poly(lactide- co -glycolide) (PLG) nanoparticle treatment mitigates the development of post-SCI neuropathic pain in female mice. Our results show that acute treatment with PLG nanoparticles following thoracic SCI significantly reduces tactile and cold hypersensitivity scores in a durable fashion. Nanoparticles primarily reduce peripheral immune-mediated mechanisms of neuropathic pain, including neuropathic pain-associated gene transcript frequency, transient receptor potential ankyrin 1 nociceptor expression, and MCP-1 (CCL2) chemokine …

Enhancing Organisational Performance Through Patient-Focused Learning Excellence In The Biopharmaceutical Industry, Lori Richter

Dissertations

Drug shortages, quality defects and challenges regarding innovation within the biopharmaceutical industry pose significant risks to patient safety and organisational performance. These problems persist despite the many scientific, technological and economic advances over the past several years in a well-funded, high-revenue industry operated by highly qualified personnel. Evidence suggests that the industry has yet to fully realise the potential for building organisational capabilities to enable learning from mistakes to enhance performance outcomes. This research study explored how biopharmaceutical companies can learn from their mistakes and embrace a culture of learning in order to reduce quality defects and drug shortages by …

Student Perspectives On The Adequacy Of Mental Health Curriculum Within The College Of Health And Human Services At Unh, Brianna Lee Meyer

Honors Theses and Capstones

This study aims to understand the confidence students in future healthcare oriented majors feel in regards to treating or interacting with individuals with mental health conditions. It also aims to understand the effect of students' in-major education, outside-major education, and lived experience on this confidence level. Students within the College of Health and Human Services at UNH were the participants who completed a short Qualtrics survey online. The survey collected data from Likert scales and short-answer questions. The Likert scales were then analyzed with a regression and descriptive statistics, while the short-answer questions were analyzed with thematic analysis. The study …

Inclusivity Of In Vitro Fertilization Clinic Websites, Erin Donahue

Honors Theses and Capstones

In the world, many people cannot naturally conceive children. They may be infertile, lack an intimate partner, or be in a same-sex relationship. Artificial reproductive technologies (ARTs) are catered to the aforementioned population. ARTs are fertility treatments that assist people with the fertilization of gametes and/or implantation of embryos. One of the most popular ARTs is in-vitro fertilization (IVF). IVF is a medical procedure in which an egg is fertilized by sperm in a lab so it can develop into an embryo. That embryo can then be implanted directly into the uterus. This quality improvement project aims to determine the …

Why Would Anybody Self-Harm?, Alina M. Baltazar

Lake Union Herald

No abstract provided.

Reflections On Channelling Innovation Through Learning Development Support In Business Education In A Pandemic Landscape, Roisin Donnelly

Journal Articles

The pandemic has undoubtedly challenged higher education (HE) in a multitude of ways but bringing lessons forward from that time can enable HE institutions and their staff to not lose sight of what innovative practices emerged that had a positive influence on student learning. Discussed from the perspective of a Head of Learning Development in a Business College which is now located in what is a new Technological University in Ireland, this reflective narrative discusses supporting staff across the diversity of Business disciplines during the impact of, and response to, the pandemic. The focus of the piece is on supporting …

Spectroscopic Serology For The Quantitative Screening Of Carotenoid Compounds In Human Blood – Correlation With Clinical Macular Pigment Factors, Joy Udensi

Doctoral

Carotenoids represent a wide range of naturally occurring pigmented compounds with an obvious presence in many plants and some animals. They constitute an important component of the human diet and have been widely recognised for their antioxidant and vision protection advantages.

Targeted Procedure Lab To Improve Self-Identified Deficiencies Among Graduating Emergency Medicine Residents, Stephanie Cohen, Andrew Bobbett, Shayne Gue, Jeffrey Thompson

North Florida Division GME Research Day 2024

No abstract provided.

Quality Improvement To Optimize Pediatric Mri Efficiency In Hospitalized Patients:Improving The Ordering Process And Reducing Time To Mri Completion, Andrew Stack, John Adent, Eric Shaw

South Atlantic Division GME Research Day 2024

No abstract provided.

Enhanced Naloxone Prescribing For Opioid-Using Patients On Hospital Discharge, Dang Quang-Trung, Joan Hyland, Barbara Gracious, Robyn Meadows

South Atlantic Division GME Research Day 2024

No abstract provided.

Assessment Of Structured Research Curriculum On Resident Scholarly Activity, Trevi Mancilla, Ryan Knight, Marshall Spiegel

Continental, MidAmerica, & Mountain Divisions GME Research Day 2024

No abstract provided.

A Case Of Parenchymal Hemorrhade Secondary To Dural Venous Sinus Thrombosis, Parnia Forouzan, Jesse Cai, Dewey Le

Gulf Coast Division GME Research Symposium 2024

No abstract provided.

Acyclovir As A Novel Treatment For Severe Chronic Active Epstein-Barr Virus, Mary Therese Thomas, Philip Mardock, Amanda Wright, Kedar Arukala

South Atlantic Division GME Research Day 2024

No abstract provided.

Interventional Radiology Approaches For Grade Iv-V Renal Injuries, Rohan Kapuria, Rishabh Agrawal, Hanping Wu

South Atlantic Division GME Research Day 2024

No abstract provided.

Where You See Smoke, There Is Probably Fire, Algimantas Simpson, Isait Alvarado, Marvin Sineath Jr.

South Atlantic Division GME Research Day 2024

No abstract provided.

Blunt Traumatic Pancreatitis In Pediatric Patient After Wrestling Injury, Connor Talbott, Jason An

Far West Division GME Research Day 2024

No abstract provided.

A Case Of Primary Cutaneous Cd4+ Small/Medium Sized Pleomorphic T-Cell Lymphoproliferative Disorder, Anthony Concilla, Michelle Militello, Sarah Ferrer-Bruker

South Atlantic Division GME Research Day 2024

No abstract provided.

Cutaneous Leishmaniasis In The Setting Of Syphilis On The Us-Mx Border, Jourdan Harper, Enkhbileg Batbileg, Andrew Bush, Cesar Calianga, Hector Zepeda

Central & West Texas GME Research Day 2024

No abstract provided.

Pre-Workout Pancreatitis, Mohammad Ridha, Gilberto Rivera-Gonzalez, Seenivasagam Makeswaran

Central & West Texas GME Research Day 2024

No abstract provided.

Plasma Cell Rich Lymphoid Neoplasm In An Endocervical Polyp Of The Uterine Cervix In A Perimenopausal 52-Year-Old Woman, Anjali Patel, Jacqueline Haas, Angela Kueck

Central & West Texas GME Research Day 2024

No abstract provided.

Perforated Marginal Ulcer Resulting In A Gastropericardial Fistula: Endoscopic Management Of A Rare Complication After Roux-En-Y Gastric Bypass, Maximillian Starr, Andrew Nicholson, Kenneth Copperwheat

Continental, MidAmerica, & Mountain Divisions GME Research Day 2024

No abstract provided.

Systemic Lupus Erythematosus Presenting As Aseptic Meningitis And Pancytopenia, Julia Collins, Roy Escobar, Vishnu Halthore, Ali Abu-Alya, Tanvir Khosla, Hamza Hansoti, Janita Sidhu, Elia Barraza, Zachary Charif, Azaam Mamoor, Ann Wierman, Venkatachalam Veerappan

Far West Division GME Research Day 2024

No abstract provided.

Thinking Outside The Operating Room: An Effective Strategy For Stoma Outlet Obstruction, Tyler Wilson, Tadevos Makaryan, Tamir E. Bresler, Manabu Fujita

Far West Division GME Research Day 2024

No abstract provided.

Bringing Awareness To The New Treatment Options For Diabetic Ketoacidosis, Raymond Alvarez, Summer Alvarez, Kristina Ledbetter, Sean Quinonez

West Florida Division GME Research Day 2024

No abstract provided.