Medicine and Health Sciences Commons^™

Dimerization Of The 4ig Isoform Of B7-H3 In Tumor Cells Mediates Enhanced Proliferation And Tumorigenic Signaling, Margie N Sutton, Sarah E Glazer, Riccardo Muzzioli, Ping Yang, Seth T Gammon, David Piwnica-Worms

Faculty, Staff and Student Publications

B7-H3 (CD276) has two isoforms (2Ig and 4Ig), no confirmed cognate receptor, and physiological functions that remain elusive. While differentially expressed on many solid tumors correlating with poor survival, mechanisms of how B7-H3 signals in cis (tumor cell) versus in trans (immune cell co-regulator) to elicit pro-tumorigenic phenotypes remain poorly defined. Herein, we characterized a tumorigenic and signaling role for tumor cell-expressed 4Ig-B7-H3, the dominant human isoform, in gynecological cancers that could be abrogated upon CRISPR/Cas9 knockout of B7-H3; tumorigenesis was rescued upon re-expression of 4Ig-B7-H3. Size exclusion chromatography revealed dimerization states for the extracellular domains of both human 4Ig- …

A Data-Driven Methodology To Comprehensively Assess Bone Drilling Using Radar Plots, Aman Nigam, James F Kellam, Catherine G Ambrose, Bruce L Tai

Faculty, Staff and Student Publications

BACKGROUND: The study aims to develop a data-driven methodology to assess bone drilling in preparation for future clinical trials in residency training. The existing assessment methods are either subjective or do not consider the interdependence among individual skill factors, such as time and accuracy. This study uses quantitative data and radar plots to visualize the balance of the selected skill factors.

METHODS: In the experiment, straight vertical drilling was assessed across 3 skill levels: expert surgeons (N = 10), intermediate residents (postgraduate year-2-5, N = 5), and novice residents (postgraduate year-1, N = 10). Motion and force were measured for …

Pancanqtlv20: A Comprehensive Resource For Expression Quantitative Trait Loci Across Human Cancers, Chengxuan Chen, Yuan Liu, Mei Luo, Jingwen Yang, Yamei Chen, Runhao Wang, Joseph Zhou, Yong Zang, Lixia Diao, Leng Han

Faculty, Staff and Student Publications

Expression quantitative trait locus (eQTL) analysis is a powerful tool used to investigate genetic variations in complex diseases, including cancer. We previously developed a comprehensive database, PancanQTL, to characterize cancer eQTLs using The Cancer Genome Atlas (TCGA) dataset, and linked eQTLs with patient survival and GWAS risk variants. Here, we present an updated version, PancanQTLv2.0 (https://hanlaboratory.com/PancanQTLv2/), with advancements in fine-mapping causal variants for eQTLs, updating eQTLs overlapping with GWAS linkage disequilibrium regions and identifying eQTLs associated with drug response and immune infiltration. Through fine-mapping analysis, we identified 58 747 fine-mapped eQTLs credible sets, providing mechanic insights of gene regulation in …

Fall Prevention In Behavioral Health, Kanesha Moss

All Doctor of Nursing Practice (DNP) Scholarly Projects

Problem:

Falls in hospital settings pose significant safety and financial risks, particularly in Behavioral Health Units (BHU), where fall rates often exceed national averages. Despite traditional fall prevention practices, such as risk assessments and post-fall huddles, the target BH unit continued to experience high fall rates, failing to meet the National Database of Nursing Quality Indicators (NDNQI) standards. The lack of alignment between fall prevention strategies and the unique needs of behavioral health patients contributed to these unmet targets.

Aim of the Project:

This project aimed to reduce the number of falls in a 41-bed BH unit by 20% over …

A High-Protein Diet Promotes Atrial Arrhythmogenesis Via Absent-In-Melanoma 2 Inflammasome, Jia Song, Jiao Wu, Dexter J Robichaux, Tingting Li, Shuyue Wang, Maria J Arredondo Sancristobal, Bingning Dong, Dobromir Dobrev, Jason Karch, Sandhya S Thomas, Na Li

Faculty, Staff and Students Publications

High-protein diets (HPDs) offer health benefits, such as weight management and improved metabolic profiles. The effects of HPD on cardiac arrhythmogenesis remain unclear. Atrial fibrillation (AF), the most common arrhythmia, is associated with inflammasome activation. The role of the Absent-in-Melanoma 2 (AIM2) inflammasome in AF pathogenesis remains unexplored. In this study, we discovered that HPD increased susceptibility to AF. To demonstrate the involvement of AIM2 signaling in the pathogenesis of HPD-induced AF, wildtype (WT) and Aim2^−/− mice were fed normal-chow (NC) and HPD, respectively. Four weeks later, inflammasome activity was upregulated in the atria of WT-HPD mice, but not …

A Retrospective Genomic Landscape Of 661 Young Adult Glioblastomas Diagnosed Using 2016 Who Guidelines For Central Nervous System Tumors, James F Haberberger, Worthy Pegram, Nicholas Britt, Kelsie Schiavone, Eric Severson, Radwa Sharaf, Lee A Albacker, Erik Williams, Mirna Lechpammer, Amanda Hemmerich, Douglas Lin, Richard S P Huang, Matthew Hiemenz, Julia Elvin, Ryon Graf, Glenn Lesser, David Kram, Roy Strowd, Wenya Linda Bi, Lori A Ramkissoon, Michael B Cohen, Prasanth Reddy, James Creeden, Jeffrey S Ross, Brian M Alexander, Shakti H Ramkissoon

Faculty, Staff and Student Publications

The authors present a cohort of 661 young adult glioblastomas diagnosed using 2016 WHO World Health Organization Classification of Tumors of the Central Nervous System, utilizing comprehensive genomic profiling (CGP) to explore their genomic landscape and assess their relationship to currently defined disease entities. This analysis explored variants with evidence of pathogenic function, common copy number variants (CNVs), and several novel fusion events not described in literature. Tumor mutational burden (TMB) mutational signatures, anatomic location, and tumor recurrence are further explored. Using data collected from CGP, unsupervised machine-learning techniques were leveraged to identify 10 genomic classes in previously assigned young …

Surgical Management Of Choanal Atresia: Two Classic Cases And Review Of The Literature, Philipp Karschnia, Jorg Dietrich, Francesco Bruno, Antonio Dono, Stephanie T Juenger, Nico Teske, Jacob S Young, Tommaso Sciortino, Levin Häni, Martin Van Den Bent, Michael Weller, Michael A Vogelbaum, Ramin A Morshed, Alexander F Haddad, Annette M Molinaro, Nitin Tandon, Juergen Beck, Oliver Schnell, Lorenzo Bello, Shawn Hervey-Jumper, Niklas Thon, Stefan J Grau, Yoshua Esquenazi, Roberta Rudà, Susan M Chang, Mitchel S Berger, Daniel P Cahill, Joerg-Christian Tonn

Faculty, Staff and Student Publications

BACKGROUND: Resection of the contrast-enhancing (CE) tumor represents the standard of care in newly diagnosed glioblastoma. However, some tumors ultimately diagnosed as glioblastoma lack contrast enhancement and have a 'low-grade appearance' on imaging (non-CE glioblastoma). We aimed to (a) volumetrically define the value of non-CE tumor resection in the absence of contrast enhancement, and to (b) delineate outcome differences between glioblastoma patients with and without contrast enhancement.

METHODS: The RANO resect group retrospectively compiled a global, eight-center cohort of patients with newly diagnosed glioblastoma per WHO 2021 classification. The associations between postoperative tumor volumes and outcome were analyzed. Propensity score-matched …

Clinicalomicsdb: Exploring Molecular Associations Of Oncology Drug Responses In Clinical Trials, Chang In Moon, John Michael Elizarraras, Jonathan Thomas Lei, Byron Jia, Bing Zhang

Faculty, Staff and Students Publications

Matching patients to optimal treatment is challenging, in part due to the limited availability of real-world clinical datasets for predictive biomarker identification. The growing integration of omics profiling into clinical trials presents a new opportunity to tackle this challenge. Here, we introduce ClinicalOmicsDB, a web application for exploring molecular associations of oncology drug responses in clinical trials. This database includes transcriptomic data from 40 clinical trial studies, with 5913 patients spanning 11 cancer types. These studies include 67 treatment arms with a variety of chemotherapy, targeted therapy and immunotherapy drugs, and their combinations, which we organize based on an established …

Updates To The Modern Diagnosis Of Gerd: Lyon Consensus 2.0, C Prakash Gyawali, Et Al.

2020-Current year OA Pubs

The Lyon Consensus provides conclusive criteria for and against the diagnosis of gastro-oesophageal reflux disease (GERD), and adjunctive metrics that consolidate or refute GERD diagnosis when primary criteria are borderline or inconclusive. An international core and working group was assembled to evaluate research since publication of the original Lyon Consensus, and to vote on statements collaboratively developed to update criteria. The Lyon Consensus 2.0 provides a modern definition of actionable GERD, where evidence from oesophageal testing supports revising, escalating or personalising GERD management for the symptomatic patient. Symptoms that have a high versus low likelihood of relationship to reflux episodes …

Phase I Dose-Escalation Study Of The Safety And Pharmacokinetics Of Ags15e Monotherapy In Patients With Metastatic Urothelial Carcinoma, Daniel P Petrylak, Joel Picus, Et Al.

2020-Current year OA Pubs

PURPOSE: Effective treatment of locally advanced or metastatic urothelial carcinoma (mUC) remains an unmet need. Antibody-drug conjugates (ADC) providing targeted drug delivery have shown antitumor activity in this setting. AGS15E is an investigational ADC that delivers the cytotoxic drug monomethyl auristatin E to cells expressing SLITRK6, a UC-associated antigen.

PATIENTS AND METHODS: This was a multicenter, single-arm, phase I dose-escalation and expansion trial of AGS15E in patients with mUC (NCT01963052). During dose escalation, AGS15E was administered intravenously at six levels (0.10, 0.25, 0.50, 0.75, 1.00, 1.25 mg/kg), employing a continual reassessment method to determine dose-limiting toxicities (DLT) and the recommended …

Dgidb 5.0: Rebuilding The Drug-Gene Interaction Database For Precision Medicine And Drug Discovery Platforms, Matthew Cannon, James Stevenson, Kathryn Stahl, Rohit Basu, Adam Coffman, Susanna Kiwala, Joshua F Mcmichael, Kori Kuzma, Dorian Morrissey, Kelsy Cotto, Elaine R Mardis, Obi L Griffith, Malachi Griffith, Alex H Wagner

2020-Current year OA Pubs

The Drug-Gene Interaction Database (DGIdb, https://dgidb.org) is a publicly accessible resource that aggregates genes or gene products, drugs and drug-gene interaction records to drive hypothesis generation and discovery for clinicians and researchers. DGIdb 5.0 is the latest release and includes substantial architectural and functional updates to support integration into clinical and drug discovery pipelines. The DGIdb service architecture has been split into separate client and server applications, enabling consistent data access for users of both the application programming interface (API) and web interface. The new interface was developed in ReactJS, and includes dynamic visualizations and consistency in the display of …

Impact Of Elexacaftor/Tezacaftor/Ivacaftor On Lipid And Fat‐Soluble Vitamin Levels And Association With Body Mass Index, Tanvi Patel, Kimberly Mcbennett, Senthilkumar Sankararaman, Teresa Schindler, Nori Mercuri Minich, Katherine Kutney

Faculty Scholarship

Introduction:Cystic fibrosis transmembrane conductance regulator (CFTR) modulators improve gastrointestinal absorption of nutrients and may result in changes in body mass index (BMI), serum lipids, and fat-soluble vitamin levels. We hypothesized that serum lipids and vitamin levels would increase with CFTR modulator therapy and that greater increase in lipids and vitamin levels would be related to greater increase in BMI. Methods:A retrospective study was performed to evaluate the impact of elexacaftor/tezacaftor/ivacaftor (ETI) on nutritional parameters, serum lipids, and fat-soluble vitamin levels. Pre-ETI values (<2 years prior) and post-ETI values (>1 month after) were compared. Linear regression was used to evaluate whether change in BMI is associated …

Alzheimer’S Disease And Microorganisms: The Non-Coding Rnas Crosstalk, Hanieh Mohammadi-Pilehdarboni, Mohammad Shenagari, Farahnaz Joukar, Hamed Naziri, Fariborz Mansour-Ghanaei

Department of Neurology Faculty Papers

Alzheimer’s disease (AD) is a complex, multifactorial disorder, influenced by a multitude of variables ranging from genetic factors, age, and head injuries to vascular diseases, infections, and various other environmental and demographic determinants. Among the environmental factors, the role of the microbiome in the genesis of neurodegenerative disorders (NDs) is gaining increased recognition. This paradigm shift is substantiated by an extensive body of scientific literature, which underscores the significant contributions of microorganisms, encompassing viruses and gut-derived bacteria, to the pathogenesis of AD. The mechanism by which microbial infection exerts its influence on AD hinges primarily on inflammation. Neuroinflammation, activated in …

Fak Drives Resistance To Therapy In Hpv-Negative Head And Neck Cancer In A P53-Dependent Manner, Phillip M Pifer, Liangpeng Yang, Manish Kumar, Tongxin Xie, Mitchell Frederick, Andrew Hefner, Beth Beadle, David Molkentine, Jessica Molkentine, Annika Dhawan, Mohamed Abdelhakiem, Abdullah A Osman, Brian J Leibowitz, Jeffrey N Myers, Curtis R Pickering, Vlad C Sandulache, John Heymach, Heath D Skinner

Faculty, Staff and Student Publications

PURPOSE: Radiation and platinum-based chemotherapy form the backbone of therapy in human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC). We have correlated focal adhesion kinase (FAK/PTK2) expression with radioresistance and worse outcomes in these patients. However, the importance of FAK in driving radioresistance and its effects on chemoresistance in these patients remains unclear.

EXPERIMENTAL DESIGN: We performed an in vivo shRNA screen using targetable libraries to identify novel therapeutic sensitizers for radiation and chemotherapy.

RESULTS: We identified FAK as an excellent target for both radio- and chemosensitization. Because TP53 is mutated in over 80% of HPV-negative HNSCC, we …

Are Remote Health Clinics Primary Health Care Focused? Validation Of The Primary Health Care Engagement (Phce) Scale For The Australian Remote Primary Health Care Setting, Kylie Mccullough, Gemma Doleman, Melissa Dunham, Lisa Whitehead, Davina Porock

Research outputs 2022 to 2026

AIM: To test and validate a measure of primary health care (PHC) engagement in the Australian remote health context. BACKGROUND: PHC principles include quality improvement, community participation and orientation of health care, patient-centred continuity of care, accessibility, and interdisciplinary collaboration. Measuring the alignment of services with the principles of PHC provides a method of evaluating the quality of care in community settings. METHODS: A two-stage design of initial content and face validity evaluation by a panel of experts and then pilot-testing the instrument via survey methods was conducted. Twelve experts from clinical, education, management and research roles within the remote …

Investigation Of The Dmft Index Of Type 2 Diabetes Mellitus Patients With A 5-Year Interval Cross Sectional Study, Oğuzhan Altun, Numan Dedeoğlu, Duygu Çelik Özen, Edanur Topaloğlu, Begüm Özemre

Future Dental Journal

Aim: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease with insulin deficiency or dysfunction. Notably, T2DM also has clinical and radiological implications in the oral region. This study aims to evaluate the changes in decay, missed, and filled teeth (DMFT) indexes on panoramic radiographs of T2DM patients at the end of a five-year follow-up and compare them with the control group.

Materials and Methods: Two panoramic radiographs taken five years (mean 5.32±0.24) apart from each of the 92 patients (46 T2DM and 46 healthy) were evaluated. The DMFT index was calculated in a total of 184 panoramic …

Effect Of Different Implant Materials On Stresses Transmitted To Peri-Implant Areas Of Implant-Retained Mandibular Overdenture, Diaa Mohamed Zahran Future University In Egypt, [email protected], Aya Fawzy Associate Professor Of Prosthodontics, Future University In Egypt, [email protected], Salah Hegazy Professor Of Prosthodontics, Faculty Of Dentistry, Mansoura University, [email protected], Sara M. Shabaan Lecturer At Removable Prosthodontic Department, Faculty Of Oral And Dental Medicine , Badr University, Cairo, Egypt, Ahmed A.Elwahed Shaaban Associate Professor Of Prosthodontics, Future University In Egypt, [email protected]

Future Dental Journal

Aim this in vitro study was conducted to evaluate the effect of mechanical loading on different implant materials on supporting structures materials and methods: a total of three implant retained overdentures were used in this study, retained by two implants each (Titanium, polyetheretherketon and zirconia) were placed in epoxy resin casts at the canine area using a surgical guide. Soft liner material was used at the distal extension area to mimic the soft tissues. Two linear strain gauges were bonded buccal and lingual to each implant to measure the peri-implant strains during unilateral and bilateral loading. Results: during bilateral loading …

Effect Of Scan Body Design On The Accuracy Of The Implant Position In Implant Supported Prosthesis, Ahmed Safwat Elghazally ,Future University In Egypt, [email protected], Bassem Mohsen Associate Professor Of Prosthodontics, Future University In Egypt, [email protected], Amr Hosny Professor Of Prosthodontics, Faculty Of Dentistry – Cairo University In Egypt, [email protected], Hussien G. Elcharkawi Professor Of Prosthodontics, Future University In Egypt, [email protected]

Future Dental Journal

Background: Several treatment options are planned for completely edentulous patients rehabilitation which were developed to meet patients desires and requirements, starting from conventional complete denture till implant supported fixed full arch cases. Each technique has its own indication and limitations. Passive fit is an important factor for the long-term success of implant- prosthesis, which necessitate accurate transfer of the implant position. Recently, digital impressions have been introduced in dental implant treatment. By the use of scan body and different optical scanning methods, the position of scan bodies can be transferred to a virtual implant position within the dental arch. Material …

Effect Of Concentrated Growth Factor Alone And Mixed With Hyaluronic Acid On Osseointegration Of Delayed Implant., Kholoud Sobhy Eldeeb Kholoud Eldeeb, Lobna Mohammed Abdelaziz, Shahira Elashiry, Eatemad Shoreibah

Future Dental Journal

Purpose: The aim of current study was evaluating effect of concentrated growth factor alone and mixed with hyaluronic acid on osseointegration of delayed implant. Subject and Methods: A total of 12 patients, ranging in age from 20 to 45 years old, were divided into two groups in random manner. Group A: Dental implants were placed associating with concentrated growth factor. Group B: Dental implants were placed associating with concentrated growth factor and hyaluronic acid. Treatment changes were evaluated for each group and compared between groups. Results: In the mean of implant stability a statistically significant difference existed within group …

Effect Of Silver Diamine Fluoride On Micro-Tensile Bond Strength Of Composite To Dentin On Primary And Permanent Teeth, Dalia Yousry Ayoub B.D.Sc Faculty Of Dentistry, Sinai University,[email protected], Osama Ibrahim El-Shahawy Professor Of Pediatric Dentistry And Dental Public Health, Faculty Of Oral And Dental Medicine, Future University In Egyp,[email protected], Sara Ahmed Mahmoud .Professor Of Pediatric Dentistry And Dental Public Health Faculty Of Oral And Dental Medicine, Cairo University,[email protected], Eman Alaa Eldeen Abd Allah Associate Professor Of Pediatric Dentistry And Dental Public Health Faculty Of Oral And Dental Medicine, Future University In Egypt,[email protected]

Future Dental Journal

Aim of the Study: The aim of the current study was to investigate the effect of silver diamine fluoride on micro-tensile bond strength of composite to dentin and on the bonding mechanism of dentin surface on primary and permanent teeth. Material and methods: This study included two groups: group 1 included twenty-four primary molars and group 2 included twenty-four premolars. Each group was further subdivided equally into sub-group A and sub-group B. Sub-groups A of each group were treated with a self-etch bonding system and 4-mm thick buildups of composite were placed with increments limited to 1 mm. Subgroups B …

The Reliability Of Soft Tissue Profile Analysis Comparing Photoshop And Cephalometric Measurements In Maxillary Protrusion Patients, Sara Usama Imam, Heba Dehis, Nagwa Elmangoury, Amr El-Beialy

Future Dental Journal

Abstract

Introduction: Cephalometric x-ray is considered as a crucial step in orthodontic diagnosis and treatment planning. However, patients nowadays, especially those pursuing cosmetic goals, are concerned about radiation dosages as a result of increased understanding. Therefore, the aim of this study is to provide a simple reliable, affordable and reproducible way to evaluate the soft tissue measures for creating an orthodontic treatment plan.

Methods: Comparing standardized profile photographs and lateral cephalograms were obtained from twenty-eight patients with maxillary protrusion of the age group between 14 – 24 years before and after retraction. Evaluation and comparison were done for cephalometric x-ray …

Evaluation Of Pain Perception Associated With Maxillary First Molars Distalization In The Presence Of Maxillary Third Molars Versus Extracted Third Molars Using Infra-Zygomatic Mini-Screws: A Randomized Clinical Trial, Nadeen H. Hafez, Yehya A. Mostafa, Amr E. El-Dakroury, Mostafa M. El-Dawlatly

Future Dental Journal

Aim: The purpose of this randomized clinical trial was to compare the pain associated with distalizing maxillary first molars with the presence versus extraction of unerupted third molars using infra-zygomaic mini -screws in a group of adolescent female patients.

Study design: This randomized clinical trial (parallel group design) was approved by the Research Ethics Committee of the Faculty of Dentistry, Future University in Egypt

Materials and methods: 30 patients requiring bilateral maxillary molar distalization using infra-zygomatic mini-implant were randomly allocated to third molar extraction (TME) or third Molar presence (TMP) groups

All patients were asked to assess their pain levels …

Comparing Program Compatibility For Dental Operators Between Different In-Office Clear Aligners Software, Karim Ibrahim Hammam, Essam Nassef, Mostafa Al Dawltaly

Future Dental Journal

Aim: The aim of the present study was to compare program compatibility for dental operators between different in office clear aligners software: (3D Maestro,3shape, BlueSky bio, Plainmeca). Materials and methods: 4 in office clear aligners software: (3D Maestro,3shape, BlueSky bio, Plainmeca) were used. Ten orthodontists were recruited for the evaluation process, A total of 48 casts were used including upper and lower arches for each case. Each orthodontist made a check mark on each option in the pre-made scoring template.A check mark with YES was given a One point, and a check mark with NO was given Zero point. Results: …

Assessment Of External Apical Root Resorption Following En-Masse And Two Steps Retraction In Maxillary Protrusion Cases: A Randomized Controlled Clinical Trial, Aya Ahmed El Ashwal, Heba Mohamed Dehis, Faten Eid

Future Dental Journal

Aim: The aim of this study was to investigate the degree of external apical root resorption (EARR) following En-masse retraction (EM) and compared it to two steps retraction technique (TS) using friction mechanics.

Materials and Methods: Thirty adult female with maxillary protrusion were randomly allocated by a computer sequence generator with 1:1 allocation ratio. EM group (mean age = 17.7 ± 1.89 years) and TS group (mean age = 17.7 ± 1.77 years). Mini-screws were inserted followed by first premolars extraction then randomization was accomplished. Patients received treatment with either EM procedure or TS to close the extraction spaces after …

Oral Focal Mucinosis: A Case Report, Hala El-Kammar Dr, Yara Youssef, Bassant Mahmoud Moustafa, Iman M. Mostafa, Noha Adel Hassanine, Adham Fahmy, Rami Guiha Dr.

Future Dental Journal

Oral focal mucinosis is a rare lesion with less than 60 cases reported in English literature so far, to the best of our knowledge. It is considered to be the oral counterpart of cutaneous focal mucinosis and/or cutaneous myxoid cyst. Histopathologically, Oral focal mucinosis is demonsterates a well-circumscribed area of myxomatous connective tissue containing mucinous material, surrounded by denser collagenous connective tissue. We present a case of Oral focal mucinosis occurring on the buccal gingiva of the lower jaw.

Correlation Between Gingival Redness And Oral Health Related Quality Of Life In A Group Of Egyptian Children At New Giza University, Fayrouz Saber, Manal Ahmed Al Sayed, Ola Moustafa Omar

Future Dental Journal

Introduction: The concept of oral health related quality of life (OHRQoL) is of great significance in the three areas of dental health, in particular the clinical practice of dentistry, research, and education. The reported prevalence of gingivitis in various developed countries is considered high. This rate escalates with the increase in age, especially around puberty. There is evidence that gingivitis is associated with the children’s OHRQoL as there are common risk factors between gingivitis’ of adolescence and their consequent OHRQoL.

Aim: This study aims to evaluate the correlation between gingival redness as evaluated by digital photographs and oral health related …

Evaluation Of Knowledge, Attitude And Practice Of Dental Interns About Using Antibiotics In Pediatric Dentistry, Ahmad Safwat Aied, Norhan Abd El-Wahab El-Dokky, Rania Abdallah Nasr

Future Dental Journal

Introduction: Antimicrobial resistance is one of the ten threats identified by the World Health Organization (WHO) in 2019, since it affects modern healthcare and the effective prevention and treatment of an ever-increasing range of infections. Recent estimates of the burden of antimicrobial resistance are very significant, with more than half a million cases of infection with selected antibiotic-resistant bacteria or new emerging resistant pathogens occurring in Europe; of note, data regarding antimicrobial resistance in low-income countries are largely unknown, increasing the overall risk of mortality, in particular in surgical procedures

Aim: The aim of the study was to evaluate the …

Implant Site Preparation Using Conventional Drilling Technique Versus Magnetic Malleting Technique (Randomized Clinical Study)., Tamer Bahaa Negidah, Ahmed Farid Shehab Prof, Hussein Hatem, Sara Zakaria Fanous, Mostafa Azab

Future Dental Journal

Background The purpose of our current study is to determine whether using a Magnetic Mallet during oral and implant surgical procedures is more effective than using traditional instruments with regard to complication rate, tissue healing, and surgical results (primary stability and crestal bone loss). According to a number of writers, a Magnetic Mallet can be utilized for implant insertion, ridge expansion, sinus lifts, tooth extractions, and implant site preparation.

So, this study was conducted to ascertain whether using a Magnetic Mallet Throughout the process of oral and surgical implant operations is effective and to assume on whether it might help …

Stability Of Immediately Placed And Delayed Implants Using Resonance Frequency Analysis (Rfa). A Systematic Review, Sara H. Younis, Catherine I. Radana, Doha M. Galal, Heba K. Abdul-Fattah, John A. Labib

Future Dental Journal

Objectives: The aim of the present Systematic Review was to compare between immediate and delayed dental implant placement using resonance frequency analysis specifically Implant Stability Quotients (ISQ).

Search methods: Search was performed in two databases (PubMed and Cochrane Library) till March 2023. Randomized clinical trials (RCTs) were included and measurements of ISQ at time of placement and time of loading were recorded. We excluded papers discussing bone grafting, orthodontic treatment and implant surface treatment.

Results: Results were above ISQ threshold value of 65, with no significant difference between immediate and delayed implants. However, Immediate placement showed shorter treatment time and …

Comparative Evaluation Of Marginal Adaptation Of Two Sealers With Two Different Obturation Techniques Using Sem (An In Vitro Study), Nada Mohammady Shaheen, Wael Hussein Kamel, Ahmed Abdel Rahman Hashem, Mahmoud Mohamed Badr

Future Dental Journal

Aim: The sealing ability of endodontic obturation plays a important role in long term prognosis of an endodontic treatment. Aim To evaluate and compare the marginal adaptation of epoxy resin-based sealer (AH Plus) versus Bioceramic-based sealer (Total fill BC Sealer) to root canals that obturated with two obturation techniques (Lateral condensation and single cone techniques) using scanning electron microscope (SEM). Materials and Methods Sixty recently extracted single rooted mandibular premolars teeth were disinfected. Access cavity preparation was performed followed by cleaning and shaping, using 2.6% NaOCl as final irrigation protocol. Teeth were then equally divided into 4 groups according to …