Medicine and Health Sciences Commons^™

Human Pluripotent Stem Cell Modeling Of Alveolar Type 2 Cell Dysfunction Caused By Abca3 Mutations, Yuliang L Sun, Erin E Hennessey, Hillary Heins, Ping Yang, Carlos Villacorta-Martin, Julian Kwan, Krithi Gopalan, Marianne James, Andrew Emili, F. Sessions Cole, Jennifer A. Wambach, Darrell N. Kotton

2020-Current year OA Pubs

Mutations in ATP-binding cassette A3 (ABCA3), a phospholipid transporter critical for surfactant homeostasis in pulmonary alveolar type II epithelial cells (AEC2s), are the most common genetic causes of childhood interstitial lung disease (chILD). Treatments for patients with pathological variants of ABCA3 mutations are limited, in part due to a lack of understanding of disease pathogenesis resulting from an inability to access primary AEC2s from affected children. Here, we report the generation of AEC2s from affected patient induced pluripotent stem cells (iPSCs) carrying homozygous versions of multiple ABCA3 mutations. We generated syngeneic CRISPR/Cas9 gene-corrected and uncorrected iPSCs and ABCA3-mutant knockin ABCA3:GFP …

Hormonal Basis Of Sex Differences In Anesthetic Sensitivity, Andrzej Z Wasilczuk, Cole Rinehart, Adeeti Aggarwal, Martha E Stone, George A Mashour, Michael S Avidan, Max B Kelz, Alex Proekt, Reccognition Study Group

2020-Current year OA Pubs

General anesthesia-a pharmacologically induced reversible state of unconsciousness-enables millions of life-saving procedures. Anesthetics induce unconsciousness in part by impinging upon sexually dimorphic and hormonally sensitive hypothalamic circuits regulating sleep and wakefulness. Thus, we hypothesized that anesthetic sensitivity should be sex-dependent and modulated by sex hormones. Using distinct behavioral measures, we show that at identical brain anesthetic concentrations, female mice are more resistant to volatile anesthetics than males. Anesthetic sensitivity is bidirectionally modulated by testosterone. Castration increases anesthetic resistance. Conversely, testosterone administration acutely increases anesthetic sensitivity. Conversion of testosterone to estradiol by aromatase is partially responsible for this effect. In contrast, …

Novel Pan-Err Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism And Mitochondrial Function, Weiyi Xu, Cyrielle Billon, Hui Li, Andrea Wilderman, Lei Qi, Andrea Graves, Jernie Rae Dela Cruz Rideb, Yuanbiao Zhao, Matthew Hayes, Keyang Yu, Mckenna Losby, Carissa S Hampton, Christiana M Adeyemi, Seok Jae Hong, Eleni Nasiotis, Chen Fu, Tae Gyu Oh, Weiwei Fan, Michael Downes, Ryan D Welch, Ronald M Evans, Aleksandar Milosavljevic, John K Walker, Brian C Jensen, Liming Pei, Thomas Burris, Lilei Zhang

Faculty, Staff and Students Publications

BACKGROUND: Cardiac metabolic dysfunction is a hallmark of heart failure (HF). Estrogen-related receptors ERRα and ERRγ are essential regulators of cardiac metabolism. Therefore, activation of ERR could be a potential therapeutic intervention for HF. However, in vivo studies demonstrating the potential usefulness of ERR agonist for HF treatment are lacking, because compounds with pharmacokinetics appropriate for in vivo use have not been available.

METHODS: Using a structure-based design approach, we designed and synthesized 2 structurally distinct pan-ERR agonists, SLU-PP-332 and SLU-PP-915. We investigated the effect of ERR agonist on cardiac function in a pressure overload-induced HF model in vivo. We …

Kinase Inhibitor Pulldown Assay (Kip) For Clinical Proteomics, Alexander B Saltzman, Doug W Chan, Matthew V Holt, Junkai Wang, Eric J Jaehnig, Meenakshi Anurag, Purba Singh, Anna Malovannaya, Beom-Jun Kim, Matthew J Ellis

Faculty, Staff and Students Publications

Protein kinases are frequently dysregulated and/or mutated in cancer and represent essential targets for therapy. Accurate quantification is essential. For breast cancer treatment, the identification and quantification of the protein kinase ERBB2 is critical for therapeutic decisions. While immunohistochemistry (IHC) is the current clinical diagnostic approach, it is only semiquantitative. Mass spectrometry-based proteomics offers quantitative assays that, unlike IHC, can be used to accurately evaluate hundreds of kinases simultaneously. The enrichment of less abundant kinase targets for quantification, along with depletion of interfering proteins, improves sensitivity and thus promotes more effective downstream analyses. Multiple kinase inhibitors were therefore deployed as …

Catalytic Isoforms Of Amp-Activated Protein Kinase Differentially Regulate Impdh Activity And Photoreceptor Neuron Function, Tae Jun Lee, Yo Sasaki, Philip A. Ruzycki, Norimitsu Ban, Joseph B. Lin, Hung-Ting Wu, Andrea Santeford, Rajendra S. Apte

2020-Current year OA Pubs

AMP-activated protein kinase (AMPK) plays a crucial role in maintaining ATP homeostasis in photoreceptor neurons. AMPK is a heterotrimeric protein consisting of α, β, and γ subunits. The independent functions of the 2 isoforms of the catalytic α subunit, PRKAA1 and PRKAA2, are uncharacterized in specialized neurons, such as photoreceptors. Here, we demonstrate in mice that rod photoreceptors lacking PRKAA2, but not PRKAA1, showed altered levels of cGMP, GTP, and ATP, suggesting isoform-specific regulation of photoreceptor metabolism. Furthermore, PRKAA2-deficient mice displayed visual functional deficits on electroretinography and photoreceptor outer segment structural abnormalities on transmission electron microscopy consistent with neuronal dysfunction, …

Ketosis Prevents Abdominal Aortic Aneurysm Rupture Through C-C Chemokine Receptor Type 2 Downregulation And Enhanced Extracellular Matrix Balance, Sergio Sastriques-Dunlop, Santiago Elizondo-Benedetto, Batool Arif, Rodrigo Meade, Mohamed S Zaghloul, Hannah Luehmann, Gyu S Heo, Sean J English, Yongjian Liu, Mohamed A Zayed

2020-Current year OA Pubs

Abdominal aortic aneurysms (AAAs) are prevalent with aging, and AAA rupture is associated with increased mortality. There is currently no effective medical therapy to prevent AAA rupture. The monocyte chemoattractant protein (MCP-1)/C-C chemokine receptor type 2 (CCR2) axis critically regulates AAA inflammation, matrix-metalloproteinase (MMP) production, and extracellular matrix (ECM) stability. We therefore hypothesized that a diet intervention that can modulate CCR2 axis may therapeutically impact AAA risk of rupture. Since ketone bodies (KBs) can trigger repair mechanisms in response to inflammation, we evaluated whether systemic ketosis in vivo could reduce CCR2 and AAA progression. Male Sprague-Dawley rats underwent surgical AAA …

Progressive Left Ventricular Remodeling For Predicting Mortality In Children With Dilated Cardiomyopathy: The Pediatric Cardiomyopathy Registry, Paul F Kantor, Charles E Canter, Et Al.

2020-Current year OA Pubs

BACKGROUND: Pediatric dilated cardiomyopathy often leads to death or cardiac transplantation. We sought to determine whether changes in left ventricular (LV) end-diastolic dimension (LVEDD), LV end-diastolic posterior wall thickness, and LV fractional shortening (LVFS) over time may help predict adverse outcomes.

METHODS AND RESULTS: We studied children up to 18 years old with dilated cardiomyopathy, enrolled between 1990 and 2009 in the Pediatric Cardiomyopathy Registry. Changes in LVFS, LVEDD, LV end-diastolic posterior wall thickness, and the LV end-diastolic posterior wall thickness:LVEDD ratio between baseline and follow-up echocardiograms acquired ≈1 year after diagnosis were determined for children who, at the 1-year …

Targeting Cell-Type-Specific, Choroid-Peripheral Immune Signaling To Treat Age-Related Macular Degeneration, Joseph B Lin, Andrea Santeford, Jason J Colasanti, Yoon Lee, Aaditya V Shah, Tzu Jui Wang, Philip A Ruzycki, Rajendra S Apte

2020-Current year OA Pubs

Age-related macular degeneration (AMD) is a leading cause of blindness featuring pathogenic neovascularization of the choroidal vasculature (CNV). Although systemic immunity plays a role in AMD, the ocular signals that recruit and activate immune cells remain poorly defined. Using single-cell RNA sequencing, we prospectively profile peripheral blood mononuclear cells from 65 individuals including AMD and controls, which we integrate with existing choroid data. We generate a network of choroid-peripheral immune interactions dysregulated in AMD, including known AMD-relevant gene vascular endothelial growth factor (VEGF) receptor 2. Additionally, we find CYR61 is upregulated in choroidal veins and may signal to circulating monocytes. …

Artworks: Art As Occupation, Erin Barrus

The Open Journal of Occupational Therapy

A collaborative effort from various artists at MRC artWorks located in Kalamazoo, MI contributed to the cover art for the Winter 2024 issue of the Open Journal of Occupational Therapy (OJOT). MRC Industries is a non-profit organization that focuses on supporting individuals with developmental disabilities, cognitive or emotional impairments or illnesses, and people who have experienced traumatic brain injuries. One particular program has become a staple in the Kalamazoo community – MRC artWorks, a professional working art studio for adults with disabilities to learn skills, both physical and emotional, through art instruction and art-making.

Exploring The Spiritual Alliance Of Maintaining A 5-Acre Tropical Farm Through The Lens Of Occupational Engagement, Jose Rafols, Amy Wagenfeld

The Open Journal of Occupational Therapy

Large-scale commercial farmers and small scale “hobby” farmers engage in growing crops for subsistence and survival for themselves, their families, communities, and beyond. Their reverence and passion for farming make them good stewards of both community and world population nourishment. We suggest there may be a collective physical, emotional, and spiritual draw to farming that is interwoven with occupational engagement. Through a personal narrative approach, we reflect on the meaning and the work-focused occupation of farming and specifically how spirituality may be a guiding force that supports engagement despite seemingly insurmountable environmental and personal hardships. With an increasing interest in …

Occupational Therapists' Role In Sexual Education For Teens And Young Adults Living With Autism Spectrum Disorder, Taylor M. Urban, Reeti R. Douglas

The Open Journal of Occupational Therapy

Teens and young adults living with autism spectrum disorder (ASD) do not have equal access to sexual education, thus having lower sexual awareness, little knowledge of preventative sexual health care, and having a more difficult time reading sexual body language (Hannah & Stagg, 2016; Holmes et al., 2019; Mogavero & Hsu, 2020). Deficits in these and many other skills may make it more challenging for teens and young adults living with ASD to engage in an intimate or sexual relationship with a consenting partner. Skilled intervention on the occupation of sexual activity and its related dimensions, such as communication and …

When Music Becomes Me: Occupational Therapy’S Role In Caring For Upper Extremity Disorders In Musicians, Kathryn S. Halsted, Kristin Biggins, Kimberly Davis

The Open Journal of Occupational Therapy

Musicians are a distinct population with a high rate of developing musculoskeletal and neurological disorders affecting their ability to participate in music-based occupations. These injuries negatively affect the musician’s health and well-being in physical, financial, psychosocial, and emotional dimensions. Given music’s complex and integrated role in the musicians’ life, treatment must be multi-dimensional, considering aspects of the person, the type of instrument, environment, context, and social obligations. Occupational therapy providers are uniquely qualified to treat musicians because of their focuse on holistic, occupation-based, and client-centered care. This manuscript describes the role of occupational therapy in this client population based on …

Outcomes Of The Nurosleeve And Occupational Therapy On Upper Limb Function Of An Individual With Chronic Hemiparesis Following A Stroke: A Case Report, Nicole M. Gerhardt, Jeremy P. Armstrong, Mijail D. Serruya, Mj Mulcahey

The Open Journal of Occupational Therapy

Background: Upper limb neuromuscular impairments can adversely impact function. This case report investigates the process and outcomes of occupational therapy (OT) for training in the use of the NuroSleeve, a novel research-grade exoskeletal powered orthosis, with a participant with chronic right hemiparesis following a stroke.

Method: The participant engaged in 24 OT sessions using the NuroSleeve over 10 weeks. Therapeutic interventions included neuromuscular reeducation, device management, and engagement in occupation-based activities with training to use the NuroSleeve. The Canadian Occupational Performance Measure (COPM), ABILHAND, Patient Reported Outcomes Measurement Information System Upper Extremity Short Form 7a (PROMIS UE SF), …

Covid-19 Pandemic’S Effect On Occupational Therapy Students’ Time-Use And Occupational Engagement On Returning To In-Person Learning, Jhannell Hannah D. Ocampo, Susan Macdermott, Karen Mccarthy

The Open Journal of Occupational Therapy

The COVID-19 pandemic emotionally and physically impacted students in occupational therapy and occupational therapy assistant programs. College students lost autonomy and access to meaningful occupations and environments. As students returned to campus, they struggled to navigate and adapt to in-person occupations and how they use their time. This study uses a mixed method descriptive research design to understand how the pandemic affected occupational therapy students' time-use and occupational engagement during the transition to in-person learning. Seventy-three students completed an online survey, while 12 of those students additionally participated in a follow-up time-use diary and interview. Eighty-three percent of the participants …

Osces’ Impact On Occupational Therapy Student Learning: Insights From Second- And Third-Year Focus Groups, Craig R. St. Jean, Karin Werther, Mary R. Roberts

The Open Journal of Occupational Therapy

Background: Objective Structured Clinical Examinations (OSCEs) are widely used in health programs to assess clinical skills. We present results of a qualitative study investigating occupational therapy students’ perceptions of OSCEs’ impact on their learning and readiness for clinical practice.

Method: Six second and six third year students in the University of Alberta’s Master of Science in Occupational Therapy program were interviewed in separate focus groups. Independent reviewers applied thematic analysis to the focus group transcripts to identify, analyze, and report themes in the data.

Results: Five themes were constructed from the data: from learning to action, transition …

Hand Strength Changes Following A Clinical Rotation In Hand Therapy: A Pilot Study, Gretchen L. Bachman, Josh Macdonald, Rhian Sage

The Open Journal of Occupational Therapy

Background: Hand therapy clinical rotations are 12 weeks, and one common anecdotal change frequently expressed is an increase in hand strength. Quantifiable measures of change are not documented in the literature. The purpose of this study is to determine if students experience significant increases in strength during a clinical rotation.

Methods: This study is a quasi-experimental, double-blinded, non-randomized sample of convenience. Grip and pinch strength were assessed pre, mid, and post clinical rotation. Demographic data were collected and reported. Paired t-tests were used to compare means between groups. SPSS 27.0 was used for data analysis.

Results: After …

Predictors Of General Well-Being In Postprofessional Students Of Occupational Science And Occupational Therapy, Elena Wong Espiritu, Paul E. Yeatts, Cynthia L. Evetts

The Open Journal of Occupational Therapy

Background: Doctoral students experience decreased well-being during their educational experience. Self-compassion, engagement in meaningful occupations, and occupational balance positively impact well-being in individuals. This study examined the relationships between these constructs in postprofessional occupational science and occupational therapy students.

Method: This quantitative cross-sectional study collected national survey data (N = 113) using the Self-Compassion Scale – Short Form, the Engagement in Meaningful Activities Survey, the Occupational Balance Questionnaire 11, and the 14-item Scales of General Well-Being. Multiple linear regression analysis determined how well each construct predicted general well-being and the strength of each construct’s relationship compared to other …

A Scoping Review Of Universal Design For Learning In United States Allied Health & Medical Education, Karolina Gawron, Madison Tomlinson, Nicole Mohan, Laura H. Vanpuymbrouck

The Open Journal of Occupational Therapy

Background: Universal design for learning (UDL) is considered best-practice for embracing inclusion for students with disabilities and there is growing evidence of its effectiveness in primary, secondary, and postsecondary education. However, little is known about if and how UDL is being implemented into United States graduate allied health and medical school curriculum as well as evidence of its benefits.

Method: We used Arksey and O’Malley’s (2005) methodological framework. Search engines were: PubMed, CINAHL Complete, ERIC, GoogleScholar, and Scopus. Data were analyzed by the research team using Covidence to organize articles, screen, and complete a full-text review. Data extraction …

Practice And Recommendations For Universal Design For Learning In Occupational Therapy Client Education, Heather L. Panczykowski, Lynne F. Murphy, Victoria Christmas, Whitely Macintyre

The Open Journal of Occupational Therapy

Background: Universal Design for Learning (UDL), an educational framework that describes flexible approaches to teaching and learning, can be used to address problems related to limitations in health literacy in health care settings.

Methods: This exploratory observational study, using a web-based online survey, was undertaken to discern how occupational therapists use the principles of UDL in educating their clients and to determine if differences exist between degree type or practice settings and UDL implementation.

Results: Of the 147 respondents only 30.6% indicated prior awareness of UDL principles. The most frequently cited means of client engagement were displaying …

Perspectives On Adaptation In A Stroke Self-Management Program: A Multiple Case Study, Riqiea F. Kitchens, Gayle Hersch, Wayne Brewer, Marsha Neville

The Open Journal of Occupational Therapy

Background: Occupational Adaptation occurs when a person develops a response to meet an occupational challenge. This process is disrupted when a person experiences a life altering event, such as stroke. Stroke self-management programs equip persons with stroke with education and skills to manage the daily tasks associated with their condition. Few studies have explored the adaptive process survivors experience as they seek to effectively use the tools provided through stroke self-management programs. The objective was to explore the adaptive process of three individuals following participation in a stroke self-management program.

Method: A multiple case study design was used. …

Cross-Cultural Adaptation Of The Inventory Of Reading Occupations-Adult Into Filipino And Its Content Validation, Peñafrancia E. Ching, Treisha Naedine H. Santos, Lenin Grajo, Maria Concepcion Cabatan, Anna Liza Y. Tan Pascual

The Open Journal of Occupational Therapy

Background: Adult functional literacy ensures adequate and safe engagement in daily activities. It is assessed through the Inventory of Reading Occupations-Adult (IRO-A). The instrument underwent translation with cultural adaptation and content validation to ensure relevance to the Filipino context.

Method: The translation and cultural adaptation of the IRO-A to Filipino (Fil IRO-A) was guided by the process proposed by two international guidelines for cross-cultural adaptations that involves (a) forward translation and synthesis, (b) back translation, and (c) pre-panel review of the adaptation to the Filipino context. The Fil IRO-A also underwent content validation by seven experts. Item and …

Confronting Systemic Racism In Occupational Therapy: A Mixed Methods Study, Rachelle Murphy, Karen Park, Christy Billock, Tracy Becerra-Culqui, Natalie A. Perkins, Rajvinder Bains

The Open Journal of Occupational Therapy

This study aimed to examine how occupational therapists and students perceive systemic racism in occupational therapy practice and the effectiveness and impact of the delivery of a keynote address on confronting systemic racism in practice delivered to occupational therapists and students. The study aimed to help inform future efforts in creating a more diverse and inclusive profession at the practice, policy, and education level by providing input into the challenges and opportunities that occupational therapists and students face when reckoning with issues of racism in practice. A mixed methodology research design was used with Likert-style scale and open-ended questions delivered …

Relationships Between Sensory Processing, Temperament Characteristics For Effortful Control, And Executive Function In School-Age Children, Rachel B. Diamant, Natasha Smet

The Open Journal of Occupational Therapy

Background: Sensory processing behaviors, the temperament characteristic for effortful control, and executive function promote self-regulation, activity engagement, and problem-solving. This study examined inter-relationships between executive function, effortful control, and sensory processing in school-aged children between 7 and 10.11 years of age.

Method: Descriptive correlation research design was used to examine relationships of outcomes from three caregiver-reported, standardized questionnaires of behaviors related to sensory processing (Sensory Profile-2), effortful control (Temperament in Middle Childhood Questionnaire) and executive function (Behavior Rating Inventory of Executive Function-2) in daily activities (N = 19).

Results: Data …

State Of The Journal: Introducing The Policy And Advocacy Category, Diane Powers Dirette

The Open Journal of Occupational Therapy

No abstract provided.

Ephrinb2 Knockdown In Cervical Spinal Cord Preserves Diaphragm Innervation In A Mutant Sod1 Mouse Model Of Als, Mark W. Urban, Brittany A. Charsar, Nicolette M. Heinsinger, Shashirekha S. Markandaiah, Lindsay Sprimont, Wei Zhou, Eric V. Brown, Nathan T. Henderson, Samantha J. Thomas, Biswarup Ghosh, Rachel E. Cain, Davide Trotti, Piera Pasinelli, Megan C. Wright, Matthew B. Dalva, Angelo C. Lepore

Farber Institute for Neuroscience Staff Papers and Presentations

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron loss. Importantly, non-neuronal cell types such as astrocytes also play significant roles in disease pathogenesis. However, mechanisms of astrocyte contribution to ALS remain incompletely understood. Astrocyte involvement suggests that transcellular signaling may play a role in disease. We examined contribution of transmembrane signaling molecule ephrinB2 to ALS pathogenesis, in particular its role in driving motor neuron damage by spinal cord astrocytes. In symptomatic SOD1G93A mice (a well-established ALS model), ephrinB2 expression was dramatically increased in ventral horn astrocytes. Reducing ephrinB2 in the cervical spinal cord ventral horn via …

Associations Of Galectin-3 Levels With Measures Of Vascular Disease In Patients With Rheumatoid Arthritis, Amanda Nussdorf, Elizabeth Park, Isabelle Amigues, Laura Geraldino-Pardilla, Sabahat Bokhari, Jon T. Giles, Joan M. Bathon

Division of Rheumatology Faculty Papers

OBJECTIVES: Galectin-3 is a beta-galactoside-binding lectin and is a marker of cardiovascular disease (CVD) in the general population. It may also play a role in joint inflammation. We asked whether serum galectin-3 is a useful marker of subclinical vascular disease in patients with rheumatoid arthritis (RA).

METHODS: RA patients without clinical CVD underwent assessment of coronary artery calcium (CAC) score, aortic inflammation (using 18Fluorodeoxyglucose positron emission-computed tomography [FDG PET/CT]), and myocardial flow reserve (MFR). Aorta FDG uptake was measured as standardized uptake values (SUV). Generalized linear models were constructed to explore the associations of galectin-3 levels with CAC score, aortic …

Conscious Selection: Critical Consciousness Informs Cultivation Of Social Networks In A Living And Learning Community, Olga Kornienko, Esther Burson, Dasean L. Young, Erin Godfrey, Pamela Garner

Psychology: Faculty Publications

Increased popular discourse about societal inequities highlights the importance of critical consciousness (CC) as a developmental competency for youth. Peer dialogue has been implicit to theories of CC, but we know little about how critical reflection, action, and sociopolitical efficacy inform interpersonal mechanisms through which social networks are selected in developmentally salient contexts. We used social network analysis methods to explore the role of CC components in how late adolescents cultivated their peer affiliation and friendship networks within a specific context of a college living and learning community. Participants (n = 37; 67.6% female; Mage = 18.18 years, 56.81% White) …

Qiditangshen Granules Alleviates Diabetic Nephropathy Podocyte Injury: A Network Pharmacology Study And Experimental Validation In Vivo And Vitro, Fei Gao, Ying Zhou, Borui Yu, Huidi Xie, Yang Shi, Xianhui Zhang, Hongfang Liu

Faculty, Staff and Student Publications

BACKGROUND: QiDiTangShen granules (QDTS), a traditional Chinese medicine (TCM) compound prescription, have remarkable efficacy in diabetic nephropathy (DN) patients, and their pharmacological mechanism needs further exploration.

METHODS: According to the active ingredients and targets of the QDTS in the TCMSP database, the network pharmacology of QDTS was investigated. The potential active ingredients were chosen based on the oral bioavailability and the drug similarity index. At the same time, targets for DN-related disease were obtained from GeneCards, OMIM, PharmGKB, TTD, and DrugBank. The TCM-component-target network and the protein-protein interaction (PPI) network were constructed with the Cytoscape and STRING platforms, respectively, and …

Modeling The Health Impact And Cost-Effectiveness Of A Combined Schoolgirl Hpv Vaccination And Cervical Cancer Screening Program In Guangdong Province, China, Yating Huang, Dantao Zhang, Lihua Yin, Jianguo Zhao, Zhifeng Li, Jing Lu, Xiaoming Zhang, Chenggang Wu, Wei Wu

Faculty, Staff and Student Publications

Low human papillomavirus (HPV) vaccine uptake is a key barrier to cervical cancer elimination. We aimed to evaluate the health impact and cost-effectiveness of introducing different HPV vaccines into immunization programs and scaling up the screening program in Guangdong. We used a dynamic compartmental model to estimate the impact of intervention strategies during 2023-2100. We implemented the incremental cost-effectiveness ratio (ICER) in costs per averted disability-adjusted life year (DALY) as an indicator to assess the effectiveness of the intervention. We used an age-standardized incidence of 4 cases per 100,000 women as the threshold for the elimination of cervical cancer. Compared …

The Association Of Dietary Antioxidants And The Inflammatory Potential Of The Diet With Poor Physical Function And Disability In Older Australian Men: The Concord Health And Ageing In Men Project, Daniela Wizgier, Ying Meng, Arpita Das, Vasi Naganathan, Fiona Blyth, David G. Le Couteur, David J. Handelsman, Louise M. Waite, Rosilene V. Ribeiro, Nitin Shivappa, James Hébert Scd, Vasant Hirani

Faculty Publications

Our objective was to evaluate the association of antioxidant intake and the inflammatory potential of the diet with functional decline in older men. A diet history questionnaire was used to collect dietary intake data from men aged ≥ 75 years (n 794) participating in the Concord Health and Aging in Men Project cohort study. Intake of vitamins A, C, E and Zn were compared with the Australian Nutrient Reference Values to determine adequacy. The Energy-adjusted Dietary Inflammatory Index (E-DIITM) was used to assess the inflammatory potential of the diet. Physical performance data were collected via handgrip strength and walking speed …