Medicine and Health Sciences Commons^™

Human Whole-Exome Genotype Data For Alzheimer's Disease, Yuk Yee Leung, Carlos Cruchaga, Et Al.

2020-Current year OA Pubs

The heterogeneity of the whole-exome sequencing (WES) data generation methods present a challenge to a joint analysis. Here we present a bioinformatics strategy for joint-calling 20,504 WES samples collected across nine studies and sequenced using ten capture kits in fourteen sequencing centers in the Alzheimer's Disease Sequencing Project. The joint-genotype called variant-called format (VCF) file contains only positions within the union of capture kits. The VCF was then processed specifically to account for the batch effects arising from the use of different capture kits from different studies. We identified 8.2 million autosomal variants. 96.82% of the variants are high-quality, and …

B Cells Mediate Lung Ischemia/Reperfusion Injury By Recruiting Classical Monocytes Via Synergistic B Cell Receptor/Tlr4 Signaling, Khashayar Farahnak, Yun Zhu Bai, Yuhei Yokoyama, Deniz B. Morkan, Zhiyi Liu, Junedh M. Amrute, Alejandro De Filippis Falcon, Yuriko Terada, Fuyi Liao, Wenjun Li, Hailey M. Shepherd, Ramsey R. Hachem, Varun Puri, Kory J. Lavine, Andrew E. Gelman, Ankit Bharat, Daniel Kreisel, Ruben G. Nava

2020-Current year OA Pubs

Ischemia/reperfusion injury-mediated (IRI-mediated) primary graft dysfunction (PGD) adversely affects both short- and long-term outcomes after lung transplantation, a procedure that remains the only treatment option for patients suffering from end-stage respiratory failure. While B cells are known to regulate adaptive immune responses, their role in lung IRI is not well understood. Here, we demonstrated by intravital imaging that B cells are rapidly recruited to injured lungs, where they extravasate into the parenchyma. Using hilar clamping and transplant models, we observed that lung-infiltrating B cells produce the monocyte chemokine CCL7 in a TLR4-TRIF-dependent fashion, a critical step contributing to classical monocyte …

Virology-The Path Forward, Angela L Rasmussen, Gigi K Gronvall, Anice C Lowen, Felicia Goodrum, James Alwine, Kristian G Andersen, Simon J Anthony, Joel Baines, Arinjay Banerjee, Andrew J Broadbent, Christopher B Brooke, Samuel K Campos, Patrizia Caposio, Arturo Casadevall, Gary C Chan, Anna R Cliffe, Donna Collins-Mcmillen, Nancy Connell, Blossom Damania, Matthew D Daugherty, Kari Debbink, Terence S Dermody, Daniel Dimaio, W Paul Duprex, Michael Emerman, Denise A Galloway, Robert F Garry, Stephen A Goldstein, Alexander L Greninger, Amy L Hartman, Brenda G Hogue, Stacy M Horner, Peter J Hotez, Jae U Jung, Jeremy P Kamil, Stephanie M Karst, Lou Laimins, Seema S Lakdawala, Igor Landais, Michael Letko, Brett Lindenbach, Shan-Lu Liu, Micah Luftig, Grant Mcfadden, Andrew Mehle, Juliet Morrison, Anne Moscona, Elke Mühlberger, Joshua Munger, Karl Münger, Eain Murphy, Christopher J Neufeldt, Janko Z Nikolich, Christine M O'Connor, Andrew Pekosz, Sallie R Permar, Julie K Pfeiffer, Saskia V Popescu, John G Purdy, Vincent R Racaniello, Charles M Rice, Jonathan A Runstadler, Martin J Sapp, Rona S Scott, Gregory A Smith, Erin M Sorrell, Emily Speranza, Daniel Streblow, Scott A Tibbetts, Zsolt Toth, Koenraad Van Doorslaer, Susan R Weiss, Elizabeth A White, Timothy M White, Christiane E Wobus, Michael Worobey, Satoko Yamaoka, Andrew Yurochko

Faculty, Staff and Students Publications

In the United States (US), biosafety and biosecurity oversight of research on viruses is being reappraised. Safety in virology research is paramount and oversight frameworks should be reviewed periodically. Changes should be made with care, however, to avoid impeding science that is essential for rapidly reducing and responding to pandemic threats as well as addressing more common challenges caused by infectious diseases. Decades of research uniquely positioned the US to be able to respond to the COVID-19 crisis with astounding speed, delivering life-saving vaccines within a year of identifying the virus. We should embolden and empower this strength, which is …

Role Of Polyunsaturated Fat In Modifying Cardiovascular Risk Associated With Family History Of Cardiovascular Disease: Pooled De Novo Results From 15 Observational Studies, Federica Laguzzi, Agneta Åkesson, Matti Marklund, Frank Qian, Bruna Gigante, Traci M Bartz, Julie K Bassett, Anna Birukov, Hannia Campos, Yoichiro Hirakawa, Fumiaki Imamura, Susanne Jäger, Maria Lankinen, Rachel A Murphy, Mackenzie Senn, Toshiko Tanaka, Nathan Tintle, Jyrki K Virtanen, Kazumasa Yamagishi, Matthew Allison, Ingeborg A Brouwer, Ulf De Faire, Gudny Eiriksdottir, Luigi Ferrucci, Nita G Forouhi, Johanna M Geleijnse, Allison M Hodge, Hitomi Kimura, Markku Laakso, Ulf Risérus, Anniek C Van Westing, Stefania Bandinelli, Ana Baylin, Graham G Giles, Vilmundur Gudnason, Hiroyasu Iso, Rozenn N Lemaitre, Toshiharu Ninomiya, Wendy S Post, Bruce M Psaty, Jukka T Salonen, Matthias B Schulze, Michael Y Tsai, Matti Uusitupa, Nicholas J Wareham, Seung-Won Oh, Alexis C Wood, William S Harris, David Siscovick, Dariush Mozaffarian, Karin Leander, Fatty Acids And Outcomes Research Consortium (Force)

Faculty, Staff and Students Publications

BACKGROUND: It is unknown whether dietary intake of polyunsaturated fatty acids (PUFA) modifies the cardiovascular disease (CVD) risk associated with a family history of CVD. We assessed interactions between biomarkers of low PUFA intake and a family history in relation to long-term CVD risk in a large consortium.

METHODS: Blood and tissue PUFA data from 40 885 CVD-free adults were assessed. PUFA levels ≤25th percentile were considered to reflect low intake of linoleic, alpha-linolenic, and eicosapentaenoic/docosahexaenoic acids (EPA/DHA). Family history was defined as having ≥1 first-degree relative who experienced a CVD event. Relative risks with 95% CI of CVD were …

Synergistic Protection Of Retinal Ganglion Cells (Rgcs) By Sarm1 Inactivation With Cntf In A Rodent Model Of Nonarteritic Anterior Ischemic Optic Neuropathy, Yan Guo, Zara Mehrabian, Jeffrey Milbrandt, Aaron Diantonio, Steven L Bernstein

2020-Current year OA Pubs

We evaluated whether inhibiting sterile alpha and (Toll/interleukin receptor (TIR)) motif-containing 1 (SARM1) activity protects retinal ganglion cells (RGCs) following ischemic axonopathy (rodent nonarteritic anterior ischemic optic neuropathy: rNAION) by itself and combined with ciliary neurotrophic factor (CNTF). Genetically modified SARM1(-) rats were rNAION-induced in one eye and compared against equivalently induced wild-type animals of the same background. Optic nerve (ON) diameters were quantified using optical coherence tomography (SD-OCT). RGCs were quantified 30 d post-induction using retinal stereology for Brn3a(+) nuclei. ON sections were analyzed by TEM and immunohistochemistry. SARM1(-)(-) and WT animals were then bilaterally sequentially rNAION-induced. One eye …

Cpsa Mediates Infection Of Recruited Lung Myeloid Cells By Mycobacterium Tuberculosis, Steven J Grigsby, G V R Krishna Prasad, Joshua B Wallach, Ekansh Mittal, Fong-Fu Hsu, Dirk Schnappinger, Jennifer A Philips

2020-Current year OA Pubs

Mycobacterium tuberculosis (Mtb) possesses an arsenal of virulence factors to evade host immunity. Previously, we showed that the Mtb protein CpsA, which protects Mtb against the host NADPH oxidase, is required in mice during the first 3 weeks of infection but is thereafter dispensable for full virulence. Using flow cytometry, we find that ΔcpsA Mtb is retained in alveolar macrophages, impaired in recruiting and disseminating into monocyte-derived cells, and more likely to be localized in airway cells than wild-type Mtb. The lungs of ΔcpsA-infected mice also have markedly fewer antigen-specific T cells, indicating a delay in adaptive immunity. Thus, we …

3rd Annual Hu Research Symposium Program 2021, Akeisha Belgrave, Erica Ward, Rebekah Harriger

Harrisburg University Research Symposium: Highlighting Research, Innovation, & Creativity

3rd Annual HU Research Symposium program and schedule of presenters. Presentations were held April 21st, 2021 virtually on the Teams platform.

Bliss, William L. Blizek, Monica Blizek

Journal of Religion & Film

This is a film review of Bliss (2022), directed by Joe Maggio.

Dosh, William L. Blizek, Monica Blizek

Journal of Religion & Film

This is a film review of Dosh (2023), directed by Radha Mehta.

You Were Never Really Here, Monica Blizek

Journal of Religion & Film

This is a film review of You Were Never Really Here (2023), directed by Flor Portieri.

Demon Mineral, Brady Desanti

Journal of Religion & Film

This is a film review of Demon Mineral (2024), directed by Hadley Austin.

2018 2nd Place: Identifying The Effectiveness Of Plant Extracts For Treating Biofilms Of Escherichia Coli And Myxococcus Xanthus, Micah Burton

Harrisburg University Research Symposium: Highlighting Research, Innovation, & Creativity

Antibiotic resistance is a topic that is of growing concern in the field of medicine. Antibiotics act as growth blockers or act as toxins, killing the organism they affect. These biological weapons generate selective pressure leading to the current antibiotic crisis. This selective pressure causes resistant organisms to begin to emerge and over generations antibiotic resistance can develop and be spread among a bacterial population.

One of the key factors contributing to antibiotic resistance in bacteria is the ability for some bacteria to form and shield themselves within biofilms. Biofilms are masses of bacteria protected by a polysaccharide/ extracellular DNA …

Identification Of Predictive Gene Signatures And Molecular Interactions Underlying Opioid Use Disorder In Brain Tissues And Peripheral Blood, Kashish Kumar

Research Symposium

Background: Opioid use disorder (OUD) is a chronic and relapsing condition influenced by genetic and environmental factors. OUD is associated with altered gene expression and epigenetic modifications in BA9 and the greater prefrontal cortex affecting regional function and connectivity. OUD may also involve the downregulation of genes related to synaptic transmission and neurogenesis in the amygdala, impairing its adaptability. In addition to the brain, peripheral blood can serve as a source of molecular markers for OUD as it is easily accessible and may reflect systemic and chronic inflammation changes prompted by OUD. Understanding the molecular mechanisms dysregulated by OUD may …

In-Silico Approach For Identifying Metabolic Proteins And Their Pathways Involved In Neurodegenerative Disorders Rna-Seq Data, Asmita Bharti, Parvesh Bubber

Research Symposium

Background: Neurodegeneration is a pathological condition where progressive loss of neuronal cells occurs in the brain. Neurodegenerative disorders have become more prevalent and by 2050, it is predicted that they will be the primary cause of ageing worldwide. Globally, the prevalence of neurodegenerative disorders like Alzheimer’s disease (AD) and Parkinson’s disease (PD) has been increasing tremendously. It has been identified that various proteins, such as APP, Tau, -synuclein, and TAR DNA-binding protein 43, are some of the main causative factors of dementia in older patients. Several studies have supported the idea that in-silico analyses using high-throughput RNA-seq data are …

Performance Of Color Plates For M. Tuberculosis Detection And Drug Resistance Screening In Mexican Tb Clinics Across The Texas Border, Sean Monday, Doris Ayala, Genesis P. Aguillón-Durán, America Cruz-Garcia, Alyssa Schami, Amberlee Hicks, Juan Ignacio Garcia, Jordi B. Torrelles, Blanca I. Restrepo

Research Symposium

Purpose: Populations along the U.S.-Mexico border have a high prevalence of risk factors for TB such as low socioeconomic status, overcrowding and migration, and consequently, higher TB incidence (up to 12 and 44/100,000) when compared to their corresponding national averages in each country. TB control in border regions is further challenged by limited access to cost-effective tests to diagnose TB and assess drug resistance (DR). We evaluated the performance of a novel, simple and low-cost culture plate technology for isolation and DR testing of Mtb in TB clinics on the Mexican border with Texas.

Methods: We conducted an observational study …

Skin Conditions And Villainous Depictions In Anime Films: Exploring Unconscious Bias In Patient-Provider Interactions, Patricia Guzman

Research Symposium

Background: Film and artistic media have the ability to influence societal perception of dermatological conditions. Literature describes how both live-action and animated films tend to depict villainous characters with a disproportionately greater number of skin conditions, thus contributing to the stigma surrounding skin conditions and their association with moral deficiency. However, the majority of literature tends to examine films of cultural, historic, and aesthetic significance in Western canon. This study seeks to include perspectives from East Asian cinema by evaluating dermatological findings of heroes and villains in popular anime films and assessing whether an increased number of skin conditions …

The Effects Of Partner Support On Breastfeeding In Underserved Nicu Latina Mothers Living Along The Us-Mexico Border, Mia Honrubia, Kassandra Garcia, Andrea P. Almaguer-Botero

Research Symposium

Introduction: Mothers of very low birthweight infants undergo many obstacles initiating, and then continuing breastfeeding. The AAP (2022) recommends exclusive breastfeeding for the first 6 months of life. A Level III NICU along the US-Mexico border, cares for over 140 VLBW infants per year. Hidalgo County is an underserved-underrepresented Latino community. 97% of our mothers live near or at the poverty level. Mothers who are newly emigrated from Mexico are often disenfranchised from our medical community and proper health care (Galvan et al. 2021). The incidence of maternal anxiety and depression in the NICU maternal population is high, adding stress …

Driscoll Children's Heart Center (Dchc): Pediatric Cardiothoracic Surgical Outcomes In Previously Underserved, Underrepresented Latino Patients Living In The Rio Grande Valley (Rgv), Kassandra Garcia, Mia Honrubia, Vincent Honrubia, Stephen M. Langley

Research Symposium

Introduction: Children are born every year with heart conditions that can range in levels of severity and differ in impact to quality of life. The Driscoll Children’s Heart Center (DCHC) comprehensively cares for children with heart conditions beginning with in utero care and follow-up through adulthood. DCHC manages all different types of Cardiac Defects including Hypoplastic Left heart Syndrome, Valve Dysfunction, Single Ventricle heart disease, transposition of the great arteries, atrioventricular septal defects and tetralogy of Fallot.

The DCHC quality data: low mortality and complication rates, and short length of stay (LOS) are cornerstones to driving quality improvement. The RGV, …

Safety And Feasibility Of Oral Pharyngeal Human Milk Therapy In Latino Vlbw Babies In A Large Level Iii Neonatal Intensive Care Unit Along The Us- Mexico Border, Kassandra Garcia, Mia Honrubia, Belen Martinez, Dynio Honrubia

Research Symposium

Introduction: The Doctors Hospital at Renaissance-Neonatal Intensive Care Unit (DHR-NICU) in Edinburg, is a large Level III/IV Regional NICU, admitting 140 Very Low Birth Weight (VLBW) babies per year. The population is 99% Latino, historically underserved and underrepresented; the unit is located 10 miles from the US- Mexico Border.

Background: Very Low Birth Weight (VLBW) infants are born too immaturely to feed human milk. In utero, the fetus continuously swallows amniotic fluid which provides growth stimulus and immune protective components. Human milk can provides essential antimicrobial agents and immune protective components to infants born prematurely, reducing the risk of major …

Prevalence Of Alternative Treatments In Patients In The Oncology Area In Northeastern Mexico, Hadassa Y. Martínez-Padrón, Hernán Uziel Vargas-Ruiz, Domingo Vargas-Gonzalez, Araní Casillas-Ramírez, J M. Guerrero-Nava

Research Symposium

Background: The treatment against cancer depends of the type of cancer and the stadium that is found, the treatment consist in the application of one or various methods, according to the American Institute for Cancer Research, the principals methods used are the following: surgery, radiotherapy, chemotherapy, immunotherapy, driven therapy, hormonal therapy, mother cells transplant, biomarker test, etc. Mexico has more than 4500 medicinal plants, and only 11% of those plants had chemical, pharmacological and biomedical efficacy. For the above, in the country stands out the use of herbalist treatment for different types of cancer, however, the published articles in this …

Prevalence Of Anxiety And Depression In Young People From Northern Tamaulipas, In The Context Of The Covid-19 Pandemic, Teresa Velázquez-Loredo

Research Symposium

Background: From the beginning of the confinement due to the Covid-19 pandemic, the prevalence of depression was >22%, while ENSANUT 2018 survey reported a prevalence of 13.6%. The pandemic had an adverse impact on young people, affecting employment, their professional future, education, training and, therefore, their mental well-being. Early studies show that young people have higher levels of anxiety and depression than adults and older adults.

Methods: We evaluated the impact of the COVID-19 pandemic on the mental health of students from the upper secondary and higher education levels of northern Tamaulipas, Mexico, measuring the prevalence of anxiety and depression …

Risk Factors For Arterial Hypertension In High School Students From Miguel Aleman And Gustavo Díaz Ordaz, Tamaulipas, Mexico, Teresa Velázquez-Loredo, Netzahualcoyotl Mayek-Pérez

Research Symposium

Background: Although arterial hypertension (AHT) in adolescents is not an important cause of morbidity and mortality, it is a public health problem that is rapidly increasing in Mexico, due to changes in lifestyle and diet that generate overweight and obesity in the population and will later impact significantly in adulthood. The earlier AHT develops the risk of acute myocardial infarctions, cerebrovascular accidents; then disabilities should be increased. These conditions have repercussions at social and economic levels.

Methods: Observational, descriptive, and cross-sectional study in students of the CBTIS 220 of Gustavo Díaz Ordaz (N = 423; women = 190, men = …

Design Of A Test For Research On Architectural Features Of Streetscape, Maria E. M. Carlier, Cristian A. Maestre, Gladys E. Maestre

Research Symposium

Background: The architectural experience may impact people’s behavior, health, and well-being, engaging several neural networks. Sensory-motor networks mediate motor responses such as approach and avoidance and spatial navigation in response to stimuli. Limbic networks process feelings and emotions. Memory-related networks support personal experiences, education, and culture. The interaction between architecture and brain sciences is known as neuroarchitecture which promises to offer biologically inspired insights into the design of spaces. We are interested in the study of neuroarchitecture applied to the streetscapes of neighborhoods in South Texas. The primary purpose of this study is to design a cognitive test to assess …

Assessing Community Health Workers Perceptions Of Their Participation In Covid-19 Related Projects Implemented Throughout South Texas And Their Alignment To The Dimensions Of Community Capacity, Eduardo Gandara Garcia, P. Recto, J. Lesser, A. Z. Idar, J. Zapata, V. Vela, M. Castilla, L. Hernandez, C. Castillo, J. Escareño, M. Flores, V. Morales

Research Symposium

Background: During the COVID-19 pandemic, Community Health Workers (CHWs) have been vital in helping to mitigate health disparities as they have helped serve as a bridge for communities and needed resources. In addition, they have been vital in improving health as they help build community capacity through their outreach, community education, and advocacy. Thus, the purpose of this project was to assess CHW’s perceptions of their participation in COVID-19 related projects implemented by the South Texas AHEC Program, throughout South Texas, and their alignment to Goodman et al.’s Dimensions of Community Capacity.

Methods: Using qualitative description, five individual semi-structured interviews …

Pulmonary Tuberculosis In Older Adults, Texas, 2008 - 2020: Trends And Adverse Outcomes, Belinda Medrano, Gretchen L. Gemeinhardt, Miryoung Lee, Sandra Morris, Lana Yamba, Blanca I. Restrepo

Research Symposium

Background: After two decades of 2% annual declines in the global incidence of TB, there was a 3.6% increase between 2020 and 2021. The World Health Organization’s (WHO) ‘End TB Strategy’ is aimed at reducing TB incidence by 80% and TB deaths by 90% by 2030, compared with 2015, but its goals will not be reached at the current pace. Reacceleration of TB elimination efforts must take into consideration the changing epidemiology of TB, including an aging global population. The older adult population, aged 65 and older, is growing faster than all other age groups, and in the United States, …

Dissecting The Influence Of Perceived Discrimination And Genetic Liability On Mental Health, Bassent Abdelbary, C. E. Guerra Amorim, P. Rodriguez, J. L. Montalvo-Ortiz

Research Symposium

Background: Underrepresented groups are disproportionally affected by discrimination, which can have long-lasting influences on the individual’s wellbeing and mental health. This study leverages the diversity of the All of Us cohort to investigate the interplay between genetic risk factors and perceived discrimination in the context of mental health disorders. This study aims to shed light into the underlying biological and environmental risk factors, and its interplay, of mental health disorders in underrepresented populations.

Methods: Data on perceived discrimination was retreived from the the All of Us (AoU) COVID-19 Participant Experience (COPE) questionnaire and matched with sociodemographic and phenotypic …

Pain Catastrophizing, Depression, And Anxiety In Tha Patients With Differing Radiographic Severity, Vanessa Lopez, Cesar Sevilla Jr., Isabella Amado, Ruthvik Allala, Y. Xi, E. P. Mulligan, Whitney Herge, Joel Wells

Research Symposium

Background: Comorbid mood disorders and pain catastrophizing behavior in patients with hip osteoarthritis have been associated with worse pain scores and more functional limitations before and after undergoing a total hip arthroplasty (THA). There remain questions regarding the relationship between severity of hip disease and mental health factors on preoperative measures in patients with differing radiographic disease. The purpose of this study was to assess preoperative pain catastrophizing, depression, and anxiety scores in THA patients with less severe radiographic hip arthritis compared to those with more severe radiographic disease.

Methods: A total of 785 patients were enrolled in a prospective …

Impacts Of Work Environment On Health Status Of Traffic Compliance And Enforcement Corps Members In Ogun State. Nigeria, Tunde Olaniyan, D. O. Babayemi, T. F. Akinhanmi, R. N. Ugbaja, O. Ademuyiwa

Research Symposium

Background: Traffic Compliance and Enforcement (TRACE) Corps members in Nigeria are occupationally exposed to lots of environmental pollutants due to essential services that they render in the transport industry. Exposure to environmental pollutants has been shown to contribute to the pathogenesis and progression of cardiovascular diseases (CVD). Information about biochemical end points of CVD in Traffic Compliance and Enforcement (TRACE) Corps members who are occupationally exposed to environmental pollutants is lacking. This study therefore investigated the effects of these environmental pollutants on some indices of CVD.

Methods: Before enrollment in the study, all subjects, including controls, were informed …

Effect Of Mir-660-5p In Breast Cancer Progression, Valeria Villarreal García, Jose Roberto Estupiñan-Jimenez, R. Noriega, Patricio A. Zapata-Morín, Recep Bayraktar, Diana Resendez-Perez, C. Rodríguez-Padilla, Jose M. Vázquez-Guillén, Fermin Mar Aguilar, Gabriel Lopez-Berestein, Pablo E. Vivas-Mejía, V. Gonzalez-Villasana

Research Symposium

Background: Breast cancer (BC) is the most diagnosed cancer in women worldwide. MicroRNAs (miRNAs) participate in different processes of BC and their deregulation can cause them to act as oncogenes or tumor suppressors, participating in cancer progression. Using the TCGA (The Cancer Genome Atlas) database, we found that miR-660-5p significantly overexpressed and associated with poor survival in patients with this pathology. Moreover, it is reported that miR-660-5p can induce BC progression through transcription factor CP2 (TFCP2) and the downregulation of tet methylcytosine dioxygenase 2 (TET2). In this project, we propose to identify the role of miR-660-5p in proliferation, migration, invasion, …

Functional Effect Of Mir-1307-3p On Breast Cancer Progression, Jose Roberto Estupiñan-Jimenez, V. Villarreal-García, R. Noriega, Patricio A. Zapata-Morín, Recep Bayraktar, Diana Reséndez-Pérez, C. Rodríguez-Padilla, Jose M. Vázquez-Guillén, Fermin Mar-Aguilar, Gabriel Lopez-Berestein, Pablo E. Vivas-Mejía, V. Gonzalez-Villasana

Research Symposium

Background: MiRNAs are non-coding RNA molecules and its function is the regulation of gene expression. In cancer, the deregulation of miRNAs allows them to act as oncogenes or tumor suppressors. From an analysis of the expression of miRNAs in breast cancer (BC) in The Cancer Genome Atlas (TCGA), it was identified that miR-1307-3p is significantly overexpressed in the tumor tissue compared to healthy tissue from patients. So far, in BC, it has only been reported that this miRNA inhibits SMYD4 and that it is involved in resistance to cisplatin through its effect on Mdm4. In this project we propose to …