Medicine and Health Sciences Commons^™

Associations Of Geographic-Based Socioeconomic Factors And Hpv Vaccination Among Male And Female Children In Five Us States, Serena Xiong, Sarah Humble, Alan Barnette, Heather Brandt, Vetta Thompson, Lisa M Klesges, Michelle I Silver

2020-Current year OA Pubs

BACKGROUND: We assessed whether five geographic-based socioeconomic factors (medically underserved area (MUA); healthcare provider shortage area (HPSA); persistent poverty; persistent child poverty; and social vulnerability index (SVI)) were associated with the odds of HPV vaccination initiation, series completion, and parental vaccine hesitancy, and whether the observed relationships varied by gender of the child.

METHODS: An online panel service, administered through Qualtrics®, was used to recruit parents of adolescents 9-17 years of age to complete a one-time survey in 2021. Coverage of the panel included five US states: Arkansas, Mississippi, Missouri, Tennessee, and Southern Illinois. Generalized estimating equation (GEE) models were …

Creating A Positive Environment For A Better Tomorrow: Culture And Climate, Kiawana Kennedy

National Youth Advocacy & Resilience Conference

Do you want resources and strategies for creating a positive climate and culture? This presentation is specifically designed for K-12 educators who are looking for ways to support positive climate and culture, Help your students develop their social-awareness, self-awareness, self-management, relationship, and responsible decision-making skills with the thousands of resources and tools through PBS LearningMedia.

An Evaluation Of The Combination Of Metformin And Y15 For The Treatment Of Platinum-Resistant Ovarian Cancer, Manuel A. Duarte, Krystal Garcia, Marco A. Arriaga, Arkene Levy, Sue Anne Chew

Research Symposium

Background: Ovarian cancer is the fifth leading cause of cancer mortality among women. This high mortality rate is linked to the development of resistance to first-line chemotherapy with platinum compounds which has been attributed in part to increased activity of focal adhesion kinase (FAK). The anti-diabetic drug Metformin was previously shown to inhibit the proliferation and migration of ovarian cancer cells and thus, the combination of a FAK inhibitor, Y15, and Metformin may be a promising treatment for platinum-resistant ovarian cancer (PROC). The objective of this study was to evaluate the combination of Y15 and Metformin on PROC cell viability …

Alteration Of The Interferon Alpha Signaling Pathway Significantly Affects Alzheimer's Disease Pathology In App/Ps1 Mouse Model., Ranjit Kumar Das, Nirakar Sahoo, Chun Xu, Hansapani Rodrigo, Michael Paul Murphy, Upal Roy, Deepa Roy

Research Symposium

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive impairment, memory loss, and disturbances in behavior. The exact cause of the disease is unknown but there is evidence of molecular pathways alteration within the brain. Many molecular mechanisms have been studied for the progression of AD. Nonetheless, the contribution of the signal transducer and activator of transcription 1 (STAT1) and interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) genes have not been well established in AD pathology. This study aimed to investigate the contribution of STAT1 and IFIT3 in the BALB/C and APP/PS1 mouse models. We analyzed the STAT1 …

A Rare Encounter: Extracranial Meningioma Mimicking Musculoskeletal Neoplasms, Liza Salloum, Jennifer Rojas Huen, Ricardo Serna, Andrew Kolodziej

Research Symposium

Background: Meningiomas are the most common primary brain tumor in adults. While commonly encountered intracranially, 2% manifest extracranially. Although usually benign, 10% of meningiomas can become malignant. Despite their relatively high incidence, they are often difficult to diagnose due to long asymptomatic periods, often diagnosed after mass effect symptoms occur. This case explores the intricacies of diagnosing and managing an extracranial meningioma that mimicked musculoskeletal neoplasms.

Case Presentation: A 70-year-old female, with a history of hypertension and dyslipidemia, presented with diplopia, blurry vision, and intermittent right orbital pain. A recent CT had identified a slow-growing right temporal mass, yet she …

Advanced Neuroimaging Findings In A Patient With Neurotoxin-Exposure Related Parkinson’S Disease: A Case Report, Kevin A. Garcia Valdez, Blake Martin, Jared Hensley, Hunter M. Butler, Russel W. Wiggins, Daniel Salinas, Chloe Harris, Nawaz Hack, Kelsey Baker

Research Symposium

Background: Neurotoxin exposure has been linked to a variety of neurological conditions and diseases. This is likely because many neurotoxins (natural and synthetic) can cross the blood brain barrier and impact the structure and function of neuronal cells and pathways. In particular, neurotoxin exposure has had a strong association with development of Parkinson’s Disease (PD), with the Department of Veteran’s affairs acknowledging the link in 2010. Here, we seek to understand if patients with PD and a history of neurotoxin-exposure demonstrate a different disease pathophysiology. Specifically, we want to evaluate microstructural changes in the brain in patients with PD and …

Addressing Educational Disparities To Improve Health In The Rio Grande Valley, Ronald A. Shaju, Alex Zuo

Research Symposium

Background. The Rio Grande Valley (RGV) has emerged as a United States region facing great hardships regarding health, with the region identified in the work with the highest rates of diabetes and obesity among the diverse mix of people that inhabit it. This extensive public health research shall seek to delve deeply into the relationships between educational disparities and health outcomes in the RGV population, as this might serve as a pivotal point for breaking down health disparities in the RGV. This comprehensive public health research endeavor seeks to delve deeply into that complicated relationship between educational disparities and the …

A Potential Role Of Urinary P75ecd As A Biomarker For Amyotrophic Lateral Sclerosis In An American Cohort, Swati Dhasmana, Anupam Dhasmana, Sheema Khan, Acharan S. Narula, Murali Yallapu, Subhash Chauhan

Research Symposium

Background: Neurological disorders present a unique complexity compared to other diseases, involving multiple risk factors, causes, treatments, and outcomes. These disorders often exhibit various molecular and morphological changes indicative of disruptions in cellular plasticity and resilience. The pathogenesis of many neurological disorders remains unclear, necessitating ongoing investigations. Amyotrophic lateral sclerosis (ALS) exemplifies an idiopathic and fatal neurodegenerative disease marked by the degeneration of upper and lower motor neurons. The average life expectancy post-diagnosis is a mere 36 months, primarily attributed to respiratory muscle denervation.The persistent challenges in ALS clinical trials and the absence of effective therapeutic options have intensified interest …

A Comparative Literature Review On Temporary Deafferentation Techniques, Maria F. Lozano Bonilla, Jared Hensley, Hunter M. Butler, Kelsey Baker

Research Symposium

Background: Temporary deafferentation (TD) is an approach aimed at improving motor and somatosensory performance by inducing temporary anesthesia, typically focused on the upper extremity. This approach has demonstrated the capacity to stimulate cortical plasticity, allowing reorganization of the primary motor and somatosensory cortices, which has proven useful in rehabilitation. Various techniques have been used to achieve temporary anesthesia, including pneumatic tourniquet cuffs, blood pressure cuffs, injections, and topical anesthetics. Here, we conducted a literature review to provide a comprehensive comparative analysis of the different methods used to perform TD in the field of neurorehabilitation and sought to identify the advantages …

Role Of Gut Microbiome In Rheumatoid Arthritis, Varsha Gupta, Jaya Prakash

Research Symposium

Background: Every individual is born with some dosha that determines its ‘Prakriti’. In the Ayurvedic text, ‘Aamvata’ is a joint disorder causing polyarticular pain and swelling like that in RA, which is texted to be the result of imbalances of gut doshas. It says that accumulation of Ama or undigested food is the cause, as they release endotoxins/ other proteins. The father of modern medicine, Hippocrates, says that the “gut is the site of all the diseases”. Traditional medicine also emphasises a balanced fibrous diet, nutrition, digestion, good sleep, yoga, and meditation, which holistically affect the body, mind and soul. …

Exploring Imageability Through Architecture To Study Neuroscience: Preliminary Results Of A Systemic Review, Cristian Maestre, Shana Garza, Silvia Mejia-Arango, Jesus D. Melgarejo, Gladys E. Maestre

Research Symposium

Background: Neuroscience and architecture are often combined to study the impact of environment, physical spaces, colors, shapes, and buildings on brain activity and health. This is an emerging field with distinct areas examining architecture in relation to neuroscience. Among the numerous elements of architecture, imageability seems to be of particular interest. Imageability refers to the quality of a physical space that evokes strong images in people’s mind, and influence cognitive functions including visual, memory, and spatial recall. It is hypothesized that environments, spaces, and buildings with poor imageability might negatively affect cognition, behavior, and brain health. Diverse studies have been …

Sick Sinus Syndrome And Takotsubo Cardiomyopathy, Oliverio Jose Abarca Guzman, Elimar Gonzalez Morales

Research Symposium

Introduction: Takotsubo cardiomyopathy (TSCM) or broken heart syndrome was first described in Japan in the 1990s, the syndrome has gained worldwide attention within the scientific community in the past few decades. The disease manifests predominantly in postmenopausal females in the presence of stressful triggers such as severe physical or emotional stress. Initially thought to be a benign condition, recent reports have demonstrated that TSCM may be associated with severe complications and mortality similar to acute coronary syndrome. Concerted efforts have been made to define various pathophysiologic aspects of TSCM; however, the precise etiologic understanding remains unclear. Some of the …

Ada News - 03/04/2024, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Acute Changes In Microvascular Resistance After Treating Aortic Stenosis, Nils P Johnson, Rob Eerdekens

Faculty, Staff and Student Publications

No abstract provided.

On The Value Of A Premium College Football Player: Evaluating The Literature, Jeremy M. Losak, Benjamin J. Posmanick, Raymond Sauer

Sport Management - All Scholarship

Over the past decade, the issue of player compensation in college sports has been the subject of several successful legal challenges. Athletes contend that the compensation they receive falls significantly short of the value they generate, attributing this gaps to unlawful NCAA restrictions. Numerous tools exist in the sport economic literature that estimate the value of colelge athletes, with an emphasized focus towards premium college football players. In addition to providing updated estimate of player marginal revenue product (MRP), we review past and contemporary methodologies for esitmating colllege player MRPs. We contend that, while presenting some evidence that restrictions on …

Genomic Epidemiology Of Mycobacterium Abscessus At An Adult Cystic Fibrosis Programme Reveals Low Potential For Healthcare-Associated Transmission, Jane E. Gross, James D. Finklea, Silvia M. Caceres, Katie R. Poch, Nabeeh A. Hasan, Fan Jia, Elaine L. Epperson, Ettie M. Lipner, Charmie K. Vang, Jennifer R. Honda, Matthew J. Strand, Vinicius Calado Nogueira De Moura, Charles L. Daley, Michael Strong, Jerry A. Nick

School of Medicine Faculty Publications and Presentations

Rationale Nontuberculous mycobacteria (NTM) has been reported to be transmitted between people with cystic fibrosis (CF) attending CF centres. A suspected Mycobacterium abscessus outbreak was investigated at the University of Texas Southwestern (UTSW) Adult CF Program using a combination of pathogen genomic sequencing and epidemiologic methods. The objectives of the present study were to apply the Healthcare-Associated Links in Transmission of NTM (HALT NTM) study to investigate the occurrence of potential healthcare-associated transmission and/or acquisition of NTM among people with CF infected with genetically similar NTM isolates. Methods Whole-genome sequencing of respiratory M. abscessus isolates from 50 people with CF …

Prevalence, Morbidity, And Mortality Of Men With Sex Chromosome Aneuploidy In The Million Veteran Program Cohort, Shanlee Davis, Craig Teerlink, Julie Lynch, Bryan Gorman, Meghana Pagadala, Aoxing Liu, Matthew Panizzon, Victoria Merritt, Giulio Genovese, Judith Ross, Richard Hauger

Department of Pediatrics Faculty Papers

IMPORTANCE: The reported phenotypes of men with 47,XXY and 47,XYY syndromes include tall stature, multisystem comorbidities, and poor health-related quality of life (HRQOL). However, knowledge about these sex chromosome aneuploidy (SCA) conditions has been derived from studies in the less than 15% of patients who are clinically diagnosed and also lack diversity in age and genetic ancestry.

OBJECTIVES: To determine the prevalence of clinically diagnosed and undiagnosed X or Y chromosome aneuploidy among men enrolled in the Million Veteran Program (MVP); to describe military service metrics of men with SCAs; and to compare morbidity and mortality outcomes between men with …

03.04.2024 Orsp Connect, Liz Williamson

ORED Newsletter

ORSP On-demand Training for PIs, Liz Williamson spotlight, Grant for Studying Clean Energy Production Awarded, NIH Simplified Peer Review Framework.

Acute And Chronic Central Nervous System Oxidative Stress/Toxicity During Hyperbaric Oxygen Treatment Of Subacute And Chronic Neurological Conditions, Paul G. Harch, Stacey Rhodes

School of Medicine Faculty Publications

INTRODUCTION: Oxygen toxicity has been defined as acute central nervous system (CNS), acute pulmonary, and chronic pulmonary oxygen toxicity. This study identifies acute and chronic CNS oxygen toxicity under 2.0 atmospheres absolute (ATA) pressure of oxygen. Methods: The authors' medical records from September 29, 1989 to January 20, 2023 and correspondence to the authors (9/1994 to 1/20.2023) from patients with signs and/or symptoms historically identified as acute CNS oxygen toxicity and those with neurological deterioration receiving hyperbaric oxygen for neurological conditions were reviewed. Acute cases were those occurring with ≤ 5 HBOTs and chronic cases > 5 HBOTs. Chronic cases were …

Intouch Week Of March 4, 2024, New York Medical College

InTouch

• HeLa Conference Navigates the Future of AI and Health Care Equity
• 2024 Alpha Omega Alpha Inductees Personify the Art of Healing
• Members of SOM Class of 2025 Recognized for Humanism in Medicine
• Department of Pathology, Microbiology and Immunology Hosts Research Symposium
• Advancing Biomedical Research Abroad Through the OVERWORLD Program
• LCME Element of the Week

Gene Expression Networks Regulated By Human Personality, Coral Del Val, Elisa Díaz De La Guardia-Bolívar, Igor Zwir, Pashupati Mishra, Alberto Mesa, Ramiro Salas, Guillermo F. Poblete, Gabriel A. De Erausquin, Emma Raitoharju, Mika Kähönen

School of Medicine Publications

Genome-wide association studies of human personality have been carried out, but transcription of the whole genome has not been studied in relation to personality in humans. We collected genome-wide expression profiles of adults to characterize the regulation of expression and function in genes related to human personality. We devised an innovative multi-omic approach to network analysis to identify the key control elements and interactions in multi-modular networks. We identified sets of transcribed genes that were co-expressed in specific brain regions with genes known to be associated with personality. Then we identified the minimum networks for the co-localized genes using bioinformatic …

Adipose Tissue Dysfunction And Energy Balance Paradigms In People Living With Hiv, Claudia E Ramirez Bustamante, Neeti Agarwal, Aaron R Cox, Sean M Hartig, Jordan E Lake, Ashok Balasubramanyam

Faculty, Staff and Students Publications

Over the past 4 decades, the clinical care of people living with HIV (PLWH) evolved from treatment of acute opportunistic infections to the management of chronic, noncommunicable comorbidities. Concurrently, our understanding of adipose tissue function matured to acknowledge its important endocrine contributions to energy balance. PLWH experience changes in the mass and composition of adipose tissue depots before and after initiating antiretroviral therapy, including regional loss (lipoatrophy), gain (lipohypertrophy), or mixed lipodystrophy. These conditions may coexist with generalized obesity in PLWH and reflect disturbances of energy balance regulation caused by HIV persistence and antiretroviral therapy drugs. Adipocyte hypertrophy characterizes visceral …

Adipose Triglyceride Lipase Is A Therapeutic Target In Advanced Prostate Cancer That Promotes Metabolic Plasticity, Dominik Awad, Pham Hong Anh Cao, Thomas L Pulliam, Meredith Spradlin, Elavarasan Subramani, Tristen V Tellman, Caroline F Ribeiro, Riccardo Muzzioli, Brittany E Jewell, Hubert Pakula, Jeffrey J Ackroyd, Mollianne M Murray, Jenny J Han, Mei Leng, Antrix Jain, Badrajee Piyarathna, Jingjing Liu, Xingzhi Song, Jianhua Zhang, Albert R Klekers, Justin M Drake, Michael M Ittmann, Cristian Coarfa, David Piwnica-Worms, Mary C Farach-Carson, Massimo Loda, Livia S Eberlin, Daniel E Frigo

Faculty, Staff and Students Publications

UNLABELLED: Lipid metabolism plays a central role in prostate cancer. To date, the major focus has centered on de novo lipogenesis and lipid uptake in prostate cancer, but inhibitors of these processes have not benefited patients. A better understanding of how cancer cells access lipids once they are created or taken up and stored could uncover more effective strategies to perturb lipid metabolism and treat patients. Here, we identified that expression of adipose triglyceride lipase (ATGL), an enzyme that controls lipid droplet homeostasis and a previously suspected tumor suppressor, correlates with worse overall survival in men with advanced, castration-resistant prostate …

Germline Genetic Testing And Survival Outcomes Among Children With Rhabdomyosarcoma: A Report From The Children's Oncology Group, Bailey A Martin-Giacalone, He Li, Michael E Scheurer, Dana L Casey, Shannon Dugan-Perez, Deborah A Marquez-Do, Donna Muzny, Richard A Gibbs, Donald A Barkauskas, David Hall, Douglas R Stewart, Joshua D Schiffman, Matthew T Mcevoy, Javed Khan, David Malkin, Corinne M Linardic, Brian D Crompton, Jack F Shern, Stephen X Skapek, Rajkumar Venkatramani, Douglas S Hawkins, Aniko Sabo, Sharon E Plon, Philip J Lupo

Faculty, Staff and Students Publications

IMPORTANCE: Determining the impact of germline cancer-predisposition variants (CPVs) on outcomes could inform novel approaches to testing and treating children with rhabdomyosarcoma.

OBJECTIVE: To assess whether CPVs are associated with outcome among children with rhabdomyosarcoma.

DESIGN, SETTING, AND PARTICIPANTS: In this cohort study, data were obtained for individuals, aged 0.01-23.23 years, newly diagnosed with rhabdomyosarcoma who were treated across 171 Children's Oncology Group sites from March 15, 1999, to December 8, 2017. Data analysis was performed from June 16, 2021, to May 15, 2023.

EXPOSURE: The presence of a CPV in 24 rhabdomyosarcoma-associated cancer-predisposition genes (CPGs) or an expanded set …

Changes In Real-World Dispensing Of Adhd Stimulants In Youth From 2019 To 2021 In California, Anika Patel, Rishikesh Chavan, Cyril Rakovski, Richard C. Beuttler, Sun Yang

Mathematics, Physics, and Computer Science Faculty Articles and Research

Introduction: Attention-deficit/hyperactivity disorder (ADHD) is one of the most common pediatric neurobehavioral disorders in the U.S. Stimulants, classified as controlled substances, are commonly used for ADHD management. We conducted an analysis of real-world stimulants dispensing data to evaluate the pandemic’s impact on young patients (≤ 26 years) in California.

Methods: Annual prevalence of patients on stimulants per capita across various California counties from 2019 and 2021 were analyzed and further compared across different years, sexes, and age groups. New patients initiating simulants therapy were also examined. A case study was conducted to determine the impact of socioeconomic status on patient …

The Moderating Effect Of Race On The Relationship Between Perceived Supervisor Support And Burnout Amongst Public Health Workers, Douglas Diontay Gaffney, Jr

Walden Dissertations and Doctoral Studies

Recent research has shown that burnout is a prevalent problem across the public health workforce. Burnout (BO) contributes to workplace challenges in turnover, employee performance, job satisfaction, and overall quality of life, and is more prevalent among racial minorities. Not only has BO been found to differ across racial demographics, employee perceptions about their level of support from supervisors (PSS) also differ. This quantitative study, informed by Meyer’s minority stress theory, examined Black-White differences in PSS and BO, and whether race moderated the relationship between PSS and BO. Data collected by De Beaumont’s 2017 national public health workforce interest and …

Surgery Of The Palatomaxillary Structure, Jessica R Burgess, Kathleen C Heneghan, Tarra G Barot, Jonah J Stulberg

Faculty, Staff and Student Publications

BACKGROUND: Patients with opioid use disorder (OUD) are increasing, challenging surgeons to adjust post-operative pain management guidelines. A literature review identified limited information on how to best care for these patients. The purpose of this study was to determine surgical perioperative management of OUD, challenges, and support needed for optimal care.

METHODS: This study utilized an anonymous voluntary survey that was distributed to members of the American College of Surgeons through the association's electronic weekly newsletter. The survey was advertised weekly for three consecutive weeks. The survey included questions regarding surgeons' management of perioperative pain in patients with opioid use …

Development Of A Follow-Up Measure To Ensure Complete Screening For Colorectal Cancer, Elizabeth L Ciemins, Jeff T Mohl, Carlos A Moreno, Francis Colangelo, Robert A Smith, Mary Barton

Faculty, Staff and Student Publications

IMPORTANCE: The current quality performance measure for colorectal cancer (CRC) screening is limited to initial screening. Despite low rates, there is no measure for appropriate follow-up with colonoscopy after receipt of an abnormal result of a stool-based screening test (SBT) for CRC. A quality performance measure is needed.

OBJECTIVE: To develop and test a quality performance measure for follow-up colonoscopy within 6 months of an abnormal result of an SBT for CRC.

DESIGN, SETTING, AND PARTICIPANTS: This retrospective quality improvement study examined data from January 1, 2016, to December 31, 2020, with 2018 plus 6 months of follow-up as the …

A Genotyping Array For The Globally Invasive Vector Mosquito, Aedes Albopictus, Luciano Veiga Cosme, Margaret Corley, Thomas Johnson, Dave W Severson, Guiyun Yan, Xiaoming Wang, Nigel Beebe, Andrew Maynard, Mariangela Bonizzoni, Ayda Khorramnejad, Ademir Jesus Martins, José Bento Pereira Lima, Leonard E Munstermann, Sinnathamby N Surendran, Chun-Hong Chen, Kevin Maringer, Isra Wahid, Shomen Mukherjee, Jiannon Xu, Michael C Fontaine, Elizabet L Estallo, Marina Stein, Todd Livdahl, Patricia Y Scaraffia, Brendan H Carter, Motoyoshi Mogi, Nobuko Tuno, James W Mains, Kim A Medley, David E Bowles, Richard J Gill, Roger Eritja, Ranulfo González-Obando, Huynh T T Trang, Sébastien Boyer, Ann-Marie Abunyewa, Kayleigh Hackett, Tina Wu, Justin Nguyễn, Jiangnan Shen, Hongyu Zhao, Jacob E Crawford, Peter Armbruster, Adalgisa Caccone

Faculty, Staff and Student Publications

BACKGROUND: Although whole-genome sequencing (WGS) is the preferred genotyping method for most genomic analyses, limitations are often experienced when studying genomes characterized by a high percentage of repetitive elements, high linkage, and recombination deserts. The Asian tiger mosquito (Aedes albopictus), for example, has a genome comprising up to 72% repetitive elements, and therefore we set out to develop a single-nucleotide polymorphism (SNP) chip to be more cost-effective. Aedes albopictus is an invasive species originating from Southeast Asia that has recently spread around the world and is a vector for many human diseases. Developing an accessible genotyping platform is essential in …

Craniofacial Bone Anomalies Related To Cholesterol Synthesis Defects, Chihiro Iwaya, Akiko Suzuki, Junbo Shim, Aemin Kim, Junichi Iwata

Faculty, Staff and Student Publications

DHCR7 and SC5D are enzymes crucial for cholesterol biosynthesis, and mutations in their genes are associated with developmental disorders, which are characterized by craniofacial deformities. We have recently reported that a loss of either Dhcr7 or Sc5d results in a failure in osteoblast differentiation. However, it remains unclear to what extent a loss of function in either DHCR7 or SC5D affects craniofacial skeletal formation. Here, using micro computed tomography (μCT), we found that the bone phenotype differs in Dhcr7